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Indifference point 0 sec

Delay discounting using a sequential patch depletion procedure, indifference point indicated by the mean amount of water available at the current feeder when the rat chose to switch to the new feeder with an experimenter-imposed delay of 0 sec

Tags: Behavior · Delay discounting

Project: p50_david_dietz

2 significantly associated models · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 7 16845355 16970279 1 1 4.7e-09 NaN NA NA NA

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 106.7 1 1 100 0 1 NA
Body weight 7.7 1 1 100 0 1 NA
Epididymis fat weight 87.6 1 1 100 0 1 NA
Glucose 5.0 1 0 0 0 1 NA
Heart weight 11.4 1 0 0 0 1 NA
Left kidney weight 37.5 1 1 100 0 1 NA
Right kidney weight 41.9 1 1 100 0 1 NA
Tail length 58.1 1 1 100 0 1 NA
Length with tail 3.2 1 0 0 0 1 NA
Length without tail 71.1 1 1 100 0 1 NA
Liver weight, left 23.6 1 1 100 0 1 NA
Liver weight, right 9.6 1 0 0 0 1 NA
Parametrial fat weight 14.9 1 1 100 0 1 NA
Retroperitoneal fat weight 3.0 1 0 0 0 1 NA
Intraocular pressure 19.0 1 1 100 0 1 NA
Extensor digitorum longus weight 25.8 1 1 100 0 1 NA
Soleus weight 13.7 1 1 100 0 1 NA
Tibialis anterior weight 59.9 1 1 100 0 1 NA
Tibia length 5.3 1 0 0 0 1 NA
Number of licking bursts 155.0 1 1 100 0 1 NA
Food consumed during 24 hour testing period 17.5 1 0 0 0 1 NA
Times rat made contact with spout 75.1 1 1 100 0 1 NA
Mean time between licks in bursts 54.9 1 1 100 0 1 NA
Mean num. licks in bursts 164.2 1 1 100 0 1 NA
Std. dev. time between licks in bursts 177.7 1 1 100 0 1 NA
Water consumed over 24 hours 5.7 1 0 0 0 1 NA
Indifference point AUC 42.1 1 1 100 0 1 NA
Indifference point function ln k 4.4 1 0 0 0 1 NA
Indifference point function log k 4.4 1 0 0 0 1 NA
Delay discounting total patch changes 0 sec 17.7 1 1 100 0 1 NA
Delay discounting total patch changes 12 sec 102.7 1 1 100 0 1 NA
Delay discounting total patch changes 18 sec 175.3 1 1 100 0 1 NA
Delay discounting total patch changes 24 sec 28.3 1 1 100 0 1 NA
Delay discounting total patch changes 6 sec 98.5 1 1 100 0 1 NA
Delay discounting water rate 0 sec 8.1 1 0 0 0 1 NA
Delay discounting water rate 12 sec 26.1 1 1 100 0 1 NA
Delay discounting water rate 18 sec 10.5 1 0 0 0 1 NA
Delay discounting water rate 24 sec 62.7 1 1 100 0 1 NA
Delay discounting water rate 6 sec 44.2 1 1 100 0 1 NA
Locomotor testing distance 11.5 1 0 0 0 1 NA
Locomotor testing rearing 16.8 1 1 100 0 1 NA
Light reinforcement 1 54.8 1 1 100 0 1 NA
Reaction time number correct 9.4 1 0 0 0 1 NA
Reaction time num false alarms 56.4 1 1 100 0 1 NA
Reaction time num false alarms AUC 79.5 1 1 100 0 1 NA
Reaction time trials correct on left 9.4 1 0 0 0 1 NA
Reaction time trials on left 10.3 1 0 0 0 1 NA
Reaction time mean 41.3 1 1 100 0 1 NA
Reaction time mean AUC 58.0 1 1 100 0 1 NA
Median of all reaction times 51.2 1 1 100 0 1 NA
Reaction time false alarm rate 63.4 1 1 100 0 1 NA
Reaction time premature initiation rate 32.1 1 1 100 0 1 NA
Reaction time premature initiations 34.3 1 1 100 0 1 NA
Std. dev. reaction times 17.4 1 1 100 0 1 NA
Reaction time trials completed 10.3 1 0 0 0 1 NA
Reaction time trials AUC 15.6 1 0 0 0 1 NA
Social responses 74.3 1 1 100 0 1 NA
Social time 7.8 1 0 0 0 1 NA
Cocaine response after cond. corrected 78.0 1 1 100 0 1 NA
Cocaine response after cond. not corrected 102.3 1 1 100 0 1 NA
Cocaine response before conditioning 17.4 1 1 100 0 1 NA
Saline control response 30.3 1 1 100 0 1 NA
Condit. Reinf. active minus inactive responses 29.4 1 1 100 0 1 NA
Condit. Reinf. active-inactive response ratio 40.7 1 1 100 0 1 NA
Condit. Reinf. active responses 7.4 1 0 0 0 1 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0 1 NA
Pavlov. Cond. lever latency 36.3 1 1 100 0 1 NA
Pavlov. Cond. magazine entry latency 104.9 1 1 100 0 1 NA
Pavlov. Cond. change in total contacts 130.1 1 1 100 0 1 NA
Pavlov. Cond. index score 62.2 1 1 100 0 1 NA
Pavlov. Cond. latency score 67.1 1 1 100 0 1 NA
Pavlov. Cond. lever contacts 17.2 1 1 100 0 1 NA
Pavlov. Cond. magazine entry number 150.0 1 1 100 0 1 NA
Pavlov. Cond. intertrial magazine entries 63.9 1 1 100 0 1 NA
Pavlov. Cond. lever-magazine prob. diff. 55.1 1 1 100 0 1 NA
Pavlov. Cond. response bias 30.8 1 1 100 0 1 NA
Conditioned reinforcement - actives 13.0 1 0 0 0 1 NA
Conditioned locomotion 9.9 1 0 0 0 1 NA
Intermittent access intake day 1-15 change 61.5 1 1 100 0 1 NA
Intermittent access intake escalation 82.5 1 1 100 0 1 NA
Intermittent access intake escalation 2 24.7 1 1 100 0 1 NA
Intermitt. access day 1 inactive lever presses 19.4 1 1 100 0 1 NA
Intermitt. access escalation Index 9.2 1 0 0 0 1 NA
Intermittent access day 1 total infusions 32.7 1 1 100 0 1 NA
Intermittent access day 1 locomotion 18.4 1 1 100 0 1 NA
Post-drug Anxiety 13.7 1 0 0 0 1 NA
Progressive ratio test 1 active lever presses 11.8 1 0 0 0 1 NA
Progressive ratio test 1 breakpoint 10.4 1 0 0 0 1 NA
Progressive ratio test 1 inactive lever presses 10.8 1 0 0 0 1 NA
Progressive ratio test 2 active lever presses 12.2 1 0 0 0 1 NA
Progressive ratio test 2 breakpoint 38.7 1 1 100 0 1 NA
Short access day 10 total inactive lever presses 9.1 1 0 0 0 1 NA
Short access day 10 total infusions 14.4 1 1 100 0 1 NA
Short access day 1 locomotion 11.4 1 0 0 0 1 NA
Compulsive drug intake 28.2 1 1 100 0 1 NA
One hour access (0.3 mA shock) 10.4 1 0 0 0 1 NA
Context. condit. distance diff. score 149.8 1 1 100 0 1 NA
Locomotion velocity, session 1 117.8 1 1 100 0 1 NA
Locomotion distance, session 1 374.7 1 1 100 0 1 NA
Locomotion velocity, session 2 82.2 1 1 100 0 1 NA
Locomotion distance, session 2 776.0 1 1 100 0 1 NA
Locomotion velocity, session 3 116.1 1 1 100 0 1 NA
Locomotion distance, session 3 82.4 1 1 100 0 1 NA
Stereotopy head waving bouts, day 3 8.8 1 0 0 0 1 NA
Stereotopy head waving duration, day 3 25.6 1 1 100 0 1 NA
Locomotion velocity, session 7 66.3 1 1 100 0 1 NA
Locomotion distance, session 7 21.3 1 1 100 0 1 NA
Stereotopy head waving bouts, day 7 42.6 1 1 100 0 1 NA
Stereotopy head waving duration, day 7 63.4 1 1 100 0 1 NA
Locomotion distance, session 8 102.8 1 1 100 0 1 NA
Degree of sensitization distance 140.6 1 1 100 0 1 NA
Degree of sensitization stereotypy 22.9 1 1 100 0 1 NA
Condit. Reinf. active minus inactive responses 5.6 1 0 0 0 1 NA
Condit. Reinf. active-inactive response ratio 65.1 1 1 100 0 1 NA
Condit. Reinf. active responses 12.2 1 0 0 0 1 NA
Condit. Reinf. inactive responses 17.2 1 0 0 0 1 NA
Incentive salience index mean 15.6 1 0 0 0 1 NA
Condit. Reinf. lever presses 20.3 1 1 100 0 1 NA
Time in familiar zone, hab. session 1 16.4 1 0 0 0 1 NA
Time in novel zone, hab. session 1 12.9 1 0 0 0 1 NA
Total zone transitions, hab. session 1 415.6 1 1 100 0 1 NA
Total locomotion distance, hab. session 1 171.4 1 1 100 0 1 NA
Locomotion velocity, hab. session 1 218.6 1 1 100 0 1 NA
Time in familiar zone, hab. session 2 28.0 1 1 100 0 1 NA
Time in novel zone, hab. session 2 34.1 1 1 100 0 1 NA
Total zone transitions, hab. session 2 256.1 1 1 100 0 1 NA
Total locomotion distance, hab. session 2 133.1 1 1 100 0 1 NA
Locomotion velocity, hab. session 2 139.4 1 1 100 0 1 NA
Total zone transitions, NPP test 228.8 1 1 100 0 1 NA
Total locomotion distance, NPP test 163.4 1 1 100 0 1 NA
Locomotion velocity, NPP test 195.9 1 1 100 0 1 NA
Pavlov. Cond. lever latency 8.6 1 0 0 0 1 NA
Pavlov. Cond. magazine entry latency 56.4 1 1 100 0 1 NA
Pavlov. Cond. change in total contacts 23.1 1 1 100 0 1 NA
Pavlov. Cond. index score 28.9 1 1 100 0 1 NA
Pavlov. Cond. latency score 16.6 1 0 0 0 1 NA
Pavlov. Cond. lever contacts 13.3 1 0 0 0 1 NA
Pavlov. Cond. magazine entry number 34.9 1 1 100 0 1 NA
Pavlov. Cond. lever-magazine prob. diff. 50.5 1 1 100 0 1 NA
Pavlov. Cond. response bias 29.4 1 1 100 0 1 NA
Bone: apparent density 18.6 1 1 100 0 1 NA
Bone surface 28.9 1 1 100 0 1 NA
Bone volume 32.3 1 1 100 0 1 NA
Bone: connectivity density 8.5 1 0 0 0 1 NA
Bone: cortical porosity 109.3 1 1 100 0 1 NA
Bone: cortical porosity 91.2 1 1 100 0 1 NA
Bone: cortical thickness 8.8 1 0 0 0 1 NA
Bone: cortical thickness 17.9 1 0 0 0 1 NA
Bone: elastic displacement 17.3 1 1 100 0 1 NA
Bone: endosteal estimation 12.7 1 1 100 0 1 NA
Bone: final force 39.5 1 1 100 0 1 NA
Bone: final moment 31.9 1 1 100 0 1 NA
Bone: marrow area 10.6 1 1 100 0 1 NA
Bone: maximum force 42.0 1 1 100 0 1 NA
Bone: maximum moment 29.5 1 1 100 0 1 NA
Bone: minimum diameter 57.3 1 1 100 0 1 NA
Bone: periosteal estimation 7.8 1 0 0 0 1 NA
Bone: periosteal perimeter 6.4 1 0 0 0 1 NA
Bone: post-yield work 82.8 1 1 100 0 1 NA
Bone: stiffness 90.4 1 1 100 0 1 NA
Bone: tissue strength 81.0 1 1 100 0 1 NA
Bone: trabecular number 39.4 1 1 100 0 1 NA
Bone: trabecular spacing 5.7 1 0 0 0 1 NA
Bone: trabecular thickness 10.4 1 0 0 0 1 NA
Bone: trabecular tissue density 43.1 1 1 100 0 1 NA
Distance traveled before self-admin 9.8 1 0 0 0 1 NA
Delta time in open arm before/after self-admin 23.6 1 1 100 0 1 NA
Extinction: sum of active levers before priming 12.2 1 0 0 0 1 NA
Active lever presses in extinction session 6 9.2 1 0 0 0 1 NA
Delta distance traveled before/after self-admin 8.7 1 0 0 0 1 NA
Delta ambulatory time before/after self-admin 4.7 1 0 0 0 1 NA
Time in closed arm before self-admin 50.0 1 1 100 0 1 NA
Time in closed arm after self-admin 25.8 1 1 100 0 1 NA
Time in open arm after self-admin 18.4 1 1 100 0 1 NA
Delta time to tail flick, vehicle, before/after SA 7.5 1 0 0 0 1 NA
Delta time to tail flick, test, before/after SA 20.0 1 0 0 0 1 NA
Ambulatory time before self-admin 5.7 1 0 0 0 1 NA
Fecal boli incidents, locomotor time 1 11.8 1 0 0 0 1 NA
Change in fecal boli incidents, locomotor task 8.8 1 0 0 0 1 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0 0 1 NA
Time >=10cm from walls, locomotor time 2 19.4 1 1 100 0 1 NA
Total resting periods, locomotor time 2 6.0 1 0 0 0 1 NA
Rest time, locomotor task time 2 7.0 1 0 0 0 1 NA
Distance moved, locomotor task time 2 9.3 1 0 0 0 1 NA
Weight adjusted by age 16.7 1 1 100 0 1 NA
Seeking ratio, delayed vs. immediate footshock 5.3 1 0 0 0 1 NA
Locomotion in novel chamber 10.2 1 0 0 0 1 NA
Run reversals in cocaine runway, males 25.4 1 1 100 0 1 NA
Latency to leave start box in cocaine runway 11.8 1 0 0 0 1 NA
Latency to leave start box in cocaine runway, M 5.6 1 0 0 0 1 NA
Cd content in liver 140.5 1 1 100 0 1 NA
Co content in liver 83.2 1 1 100 0 1 NA
Fe content in liver 10.3 1 0 0 0 1 NA
K content in liver 62.6 1 1 100 0 1 NA
Mn content in liver 130.2 1 1 100 0 1 NA
Rb content in liver 18.6 1 1 100 0 1 NA
Se content in liver 47.0 1 1 100 0 1 NA
Sr content in liver 5.6 1 0 0 0 1 NA
Zn content in liver 25.9 1 1 100 0 1 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.00 1.6
Adipose alternative TSS 0 0.00 1.7
Adipose gene expression 0 0.00 1.6
Adipose isoform ratio 0 0.00 1.7
Adipose intron excision ratio 0 0.00 1.7
Adipose mRNA stability 0 0.00 1.5
BLA alternative polyA 0 0.00 1.7
BLA alternative TSS 0 0.00 1.7
BLA gene expression 0 0.00 1.6
BLA isoform ratio 0 0.00 1.7
BLA intron excision ratio 0 0.00 1.7
BLA mRNA stability 0 0.00 1.6
Brain alternative polyA 0 0.00 1.7
Brain alternative TSS 0 0.00 1.8
Brain gene expression 0 0.00 1.6
Brain isoform ratio 0 0.00 1.7
Brain intron excision ratio 0 0.00 1.6
Brain mRNA stability 0 0.00 1.5
Eye alternative polyA 0 0.00 2.0
Eye alternative TSS 0 0.00 1.8
Eye gene expression 0 0.00 1.6
Eye isoform ratio 0 0.00 1.6
Eye intron excision ratio 0 0.00 1.6
Eye mRNA stability 0 0.00 1.8
IL alternative polyA 0 0.00 1.8
IL alternative TSS 0 0.00 1.6
IL gene expression 0 0.00 1.6
IL isoform ratio 0 0.00 1.6
IL intron excision ratio 0 0.00 1.7
IL mRNA stability 0 0.00 1.6
LHb alternative polyA 0 0.00 1.7
LHb alternative TSS 0 0.00 1.7
LHb gene expression 0 0.00 1.6
LHb isoform ratio 0 0.00 1.6
LHb intron excision ratio 0 0.00 1.7
LHb mRNA stability 0 0.00 1.6
Liver alternative polyA 0 0.00 1.7
Liver alternative TSS 0 0.00 1.7
Liver gene expression 0 0.00 1.6
Liver isoform ratio 0 0.00 1.6
Liver intron excision ratio 0 0.00 1.7
Liver mRNA stability 0 0.00 1.5
NAcc alternative polyA 0 0.00 1.6
NAcc alternative TSS 0 0.00 1.7
NAcc gene expression 0 0.00 1.6
NAcc isoform ratio 0 0.00 1.7
NAcc intron excision ratio 0 0.00 1.6
NAcc mRNA stability 0 0.00 1.6
OFC alternative polyA 0 0.00 1.6
OFC alternative TSS 0 0.00 1.6
OFC gene expression 0 0.00 1.6
OFC isoform ratio 0 0.00 1.6
OFC intron excision ratio 0 0.00 1.8
OFC mRNA stability 0 0.00 1.6
PL alternative polyA 0 0.00 1.6
PL alternative TSS 0 0.00 1.6
PL gene expression 0 0.00 1.6
PL isoform ratio 2 0.09 1.7
PL intron excision ratio 0 0.00 1.7
PL mRNA stability 0 0.00 1.5

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.