Hub : Genes

Slc35a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Slc35a1 0.09 0.06 2.8e-06 0.06 0.06 0.06 0.06 1.3e-06 4.4e-06 2.4e-06 5.9e-06
2 Adipose gene expression Slc35a1 0.1 0.07 9.6e-10 0.06 0.06 0.06 0.06 5.8e-07 2.3e-07 6.3e-07 2.3e-07
3 NAcc mRNA stability Slc35a1 0.03 0.02 4.1e-04 0.03 0.02 0.02 0.03 1.0e-04 1.3e-04 3.1e-04 9.7e-05
4 NAcc intron excision ratio chr5_54022929_54026987 0.04 0.03 3.3e-05 0.03 0.03 0.03 0.03 6.8e-06 2.7e-05 2.5e-05 1.3e-05
5 Liver gene expression Slc35a1 0.12 0.08 1.6e-12 0.08 0.09 0.07 0.09 4.8e-09 7.8e-10 4.6e-08 9.8e-10
6 NAcc intron excision ratio chr5_54027718_54029841 0.03 0.03 1.8e-05 0.04 0.03 0.04 0.04 2.8e-06 5.7e-06 2.4e-06 2.7e-06
7 NAcc intron excision ratio chr5_54027121_54027542 0.03 0.02 3.1e-04 0.02 0.02 0.01 0.02 1.7e-03 2.8e-04 6.5e-03 6.8e-04
8 BLA mRNA stability Slc35a1 0.08 0.06 7.5e-04 0.03 0.05 0.03 0.03 7.8e-03 1.7e-03 1.4e-02 1.2e-02
9 Adipose mRNA stability Slc35a1 0.05 0.03 2.4e-05 0.03 0.03 0.03 0.03 1.4e-04 2.2e-04 1.5e-04 1.8e-04
10 Brain intron excision ratio chr5_54022929_54026987 0.04 0.03 2.6e-03 0.03 0.01 0.02 0.02 3.7e-04 2.4e-02 9.9e-03 4.2e-03
11 PL intron excision ratio chr5_54027718_54029841 0.02 0.02 7.4e-03 0 0.01 0.02 0.01 2.4e-01 3.4e-02 4.5e-03 2.1e-02
12 IC intron excision ratio chr5_54022929_54026987 0.14 0.1 1.8e-05 0.02 0.1 0.07 0.05 5.6e-02 6.7e-05 5.2e-04 4.1e-03
13 PL mRNA stability Slc35a1 0.04 0.03 1.8e-04 0.02 0.03 0.02 0.02 3.4e-03 4.7e-04 3.8e-03 2.0e-03
14 IC intron excision ratio chr5_54027121_54027542 0.07 0.06 4.8e-03 -0 0.01 0.03 0.01 3.5e-01 7.9e-02 2.6e-02 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.61.11.8-1.01.01.01.01.0-0.90.91.2-1.21.2-1.3-1.30.5-1.0
Area under the delay curve0.10.10.30.6-0.1-0.2-0.2-0.20.2-0.2-0.40.2-0.10.50.4-0.1-0.1
BMI with tail3.211.217.0-3.83.53.83.83.8-3.73.92.9-3.63.7-1.3-1.74.1-1.2
BMI without tail1.68.711.9-3.42.93.23.23.2-3.23.23.2-2.82.9-2.3-2.62.6-2.4
Body weight6.026.332.6-5.75.45.65.65.6-5.65.65.0-5.25.4-4.0-3.95.1-3.7
Weight adjusted by age0.71.92.4-1.51.41.41.41.3-1.51.31.5-1.41.4-1.5-1.40.9-1.3
Bone surface1.73.46.1-1.81.81.71.71.6-1.71.52.2-1.81.7-2.4-2.50.6-2.2
Bone volume0.81.73.7-1.21.11.11.11.1-1.11.01.7-1.31.2-1.6-1.90.2-1.7
Breakpoint value in progressive ratio session0.20.30.9-0.20.20.60.60.4-0.50.30.8-0.50.5-0.9-0.9-0.0-0.5
Number of licking bursts0.00.10.20.2-0.2-0.4-0.4-0.40.3-0.4-0.20.3-0.40.20.0-0.50.1
Context. condit. distance diff. score0.81.01.50.9-1.1-1.0-1.0-0.90.9-0.9-1.11.2-1.10.51.2-0.51.0
Locomotion velocity, session 10.20.20.70.3-0.3-0.4-0.4-0.30.4-0.3-0.50.3-0.20.80.60.00.8
Locomotion distance, session 13.54.55.72.4-2.0-2.4-2.4-2.32.3-2.2-2.32.1-2.11.71.9-1.91.6
Locomotion velocity, session 20.10.10.60.00.3-0.1-0.10.00.10.1-0.4-0.20.10.50.70.50.8
Locomotion distance, session 25.17.19.72.7-2.6-2.7-2.7-2.62.7-2.5-3.12.6-2.62.83.1-1.62.6
Locomotion velocity, session 32.32.74.71.5-1.5-1.6-1.6-1.51.6-1.4-2.01.6-1.51.82.2-0.62.0
Locomotion distance, session 33.33.77.31.7-1.8-1.8-1.8-1.71.8-1.6-2.41.9-1.92.22.7-0.62.3
Stereotopy head waving bouts, day 30.91.12.4-0.90.91.01.00.8-1.00.81.2-0.91.0-1.2-1.30.3-1.6
Stereotopy head waving duration, day 31.61.92.5-1.51.51.51.51.5-1.51.51.4-1.61.6-0.9-1.21.3-1.1
Locomotion velocity, session 70.70.82.70.7-0.5-0.7-0.7-0.60.7-0.5-1.30.6-0.80.91.60.31.6
Locomotion distance, session 71.92.54.91.5-1.4-1.5-1.5-1.41.5-1.3-2.01.6-1.71.42.2-0.52.1
Stereotopy head waving bouts, day 70.50.51.8-0.80.60.80.80.8-0.70.90.1-0.40.60.70.51.40.5
Stereotopy head waving duration, day 71.82.34.5-1.71.61.71.71.8-1.71.81.1-1.51.7-0.1-0.42.1-0.2
Locomotion velocity, session 85.16.211.32.2-2.3-2.4-2.4-2.12.2-1.9-3.02.3-2.33.23.4-0.73.0
Locomotion distance, session 86.69.512.63.1-3.1-3.2-3.2-3.13.1-3.0-3.63.3-3.12.53.5-2.03.1
Degree of sensitization distance0.30.40.6-0.60.70.70.70.7-0.60.70.5-0.70.6-0.5-0.30.80.0
Degree of sensitization stereotypy0.80.93.3-0.80.60.80.80.9-0.71.0-0.2-0.50.61.31.01.81.2
Conditioned locomotion0.30.31.2-0.30.40.40.40.4-0.50.30.6-0.40.4-0.9-0.8-0.0-1.1
Cocaine response after cond. corrected0.50.81.0-0.90.71.01.01.0-1.00.91.0-0.70.7-0.9-0.80.7-0.9
Cocaine response after cond. not corrected0.20.30.5-0.60.50.60.60.6-0.60.60.7-0.40.3-0.7-0.60.4-0.7
Cocaine response before conditioning0.10.10.20.20.1-0.2-0.2-0.20.3-0.2-0.30.0-0.10.40.3-0.00.5
Saline control response0.81.12.4-0.90.91.01.00.9-0.90.91.3-1.00.8-1.6-1.40.4-1.3
Bone: connectivity density1.01.72.7-1.21.41.21.21.3-1.21.21.4-1.51.5-1.6-1.40.8-1.0
Bone: cortical apparent density0.10.10.7-0.1-0.3-0.3-0.3-0.30.1-0.30.10.3-0.30.2-0.4-0.6-0.8
Bone: cortical area3.96.48.7-2.92.72.62.62.6-2.72.62.6-2.62.5-1.9-2.22.1-2.4
Bone: cortical porosity0.40.52.50.00.20.10.1-0.1-0.1-0.20.6-0.10.1-1.3-1.1-0.8-1.6
Bone: cortical porosity0.80.92.9-0.70.90.70.70.6-0.70.61.1-0.80.8-1.4-1.30.1-1.7
Bone: cortical thickness1.01.62.9-1.71.31.31.31.3-1.41.31.3-1.21.1-0.6-1.11.1-1.4
Bone: cortical thickness0.30.41.2-0.60.60.50.50.6-0.50.70.1-0.50.50.40.41.10.7
Bone: cortical tissue density0.10.10.6-0.0-0.3-0.4-0.4-0.30.1-0.40.10.4-0.30.2-0.3-0.6-0.8
Condit. Reinf. active minus inactive responses2.62.93.81.8-1.5-1.8-1.8-1.71.8-1.6-1.91.5-1.71.71.9-1.11.9
Condit. Reinf. active-inactive response ratio0.60.71.00.8-0.7-0.8-0.8-0.90.9-0.8-0.90.7-0.90.70.8-0.71.0
Condit. Reinf. active responses1.62.03.21.4-1.2-1.5-1.5-1.41.4-1.3-1.81.2-1.31.51.8-0.71.7
Condit. Reinf. inactive responses0.70.91.81.0-0.9-1.0-1.0-0.91.0-0.8-1.20.8-0.71.21.3-0.41.0
Incentive salience index mean0.81.11.81.1-0.8-1.0-1.0-1.01.0-0.9-1.30.8-1.01.11.3-0.51.3
Condit. Reinf. lever presses0.10.10.30.10.20.10.10.0-0.10.1-0.3-0.0-0.00.20.60.40.6
Condit. Reinf. active minus inactive responses0.40.71.4-0.91.10.80.80.9-0.81.00.5-0.91.1-0.4-0.11.2-0.3
Condit. Reinf. active-inactive response ratio0.30.51.6-0.30.50.20.20.4-0.30.5-0.5-0.30.30.81.11.31.2
Condit. Reinf. active responses0.91.32.8-1.11.31.01.01.1-1.01.01.1-1.21.3-1.2-1.10.7-1.7
Condit. Reinf. inactive responses0.91.36.1-0.70.90.70.70.6-0.70.51.2-0.70.9-1.6-1.6-0.2-2.5
Condit. Reinf. lever presses1.31.92.8-1.41.71.41.41.4-1.41.41.2-1.61.6-1.2-0.91.4-1.1
Condit. Reinf. lever reinforcers received1.31.83.0-1.31.51.21.21.2-1.21.21.3-1.41.6-1.4-1.30.9-1.7
Conditioned reinforcement - actives0.10.50.8-0.90.70.70.70.8-0.80.80.5-0.70.6-0.3-0.20.9-0.1
Conditioned reinforcement - inactives0.00.00.4-0.10.2-0.0-0.0-0.2-0.0-0.1-0.20.20.0-0.60.1-0.10.0
Conditioned locomotion0.91.31.7-1.31.31.21.21.3-1.21.31.1-1.31.0-1.2-0.81.2-0.2
Patch foraging indifference point 0 sec0.10.20.4-0.20.40.30.30.4-0.20.30.5-0.50.6-0.6-0.60.1-0.2
Patch foraging indifference point AUC1.02.43.7-1.91.51.71.71.7-1.71.71.5-1.61.2-1.4-1.21.5-1.0
Delay disc. indifference point, 0s delay0.40.41.00.5-0.5-0.5-0.5-0.50.5-0.5-0.90.7-0.60.91.0-0.10.7
Delay disc. indifference point, 16s delay0.10.10.3-0.00.50.20.20.3-0.30.30.3-0.30.4-0.1-0.30.2-0.5
Delay disc. indifference point, 2s delay0.20.21.0-0.20.30.40.40.3-0.40.30.4-0.20.2-0.5-0.40.1-1.0
Delay disc. indifference point, 24s delay0.00.00.10.1-0.00.30.30.1-0.20.10.00.1-0.1-0.20.00.10.0
Delay disc. indifference point, 4s delay0.40.40.90.9-0.5-0.7-0.7-0.60.7-0.6-0.70.5-0.70.60.7-0.40.3
Delay disc. indifference point, 8s delay0.00.00.30.30.10.00.0-0.10.1-0.1-0.1-0.10.20.2-0.0-0.1-0.5
Indifference point function ln k0.10.41.10.8-0.5-0.6-0.6-0.60.6-0.5-0.70.6-0.11.00.7-0.20.8
Indifference point function log k0.10.41.10.8-0.5-0.6-0.6-0.60.6-0.5-0.70.6-0.11.00.7-0.20.8
Patch foraging total patch changes 0 sec0.00.10.2-0.10.30.20.20.3-0.10.30.3-0.40.4-0.4-0.20.20.0
Patch foraging total patch changes 12 sec0.91.32.9-1.11.31.31.31.3-1.21.40.7-1.41.1-0.2-0.11.70.1
Patch foraging total patch changes 18 sec0.10.20.5-0.60.30.40.40.4-0.30.40.5-0.40.3-0.7-0.50.2-0.2
Patch foraging total patch changes 24 sec0.51.62.9-1.11.21.41.41.2-1.21.21.4-1.41.1-1.7-1.40.8-1.3
Patch foraging total patch changes 6 sec0.20.41.3-0.60.60.50.50.6-0.40.50.7-0.60.5-1.1-0.70.3-0.4
Patch foraging time to switch 0 sec0.62.43.41.8-1.6-1.7-1.7-1.71.8-1.7-1.51.6-1.50.81.1-1.61.2
Patch foraging water rate 0 sec0.62.12.8-1.61.71.61.61.6-1.51.61.4-1.51.4-1.2-1.11.4-1.2
Patch foraging water rate 12 sec0.10.61.4-0.91.00.70.70.8-0.70.80.5-0.70.6-1.2-0.30.9-0.6
Patch foraging water rate 18 sec0.20.52.1-0.80.70.70.70.6-0.60.7-0.3-0.30.30.91.01.40.5
Patch foraging water rate 24 sec0.30.52.8-0.20.3-0.1-0.10.10.00.2-0.8-0.10.11.71.31.00.6
Patch foraging water rate 6 sec0.50.71.8-1.11.00.90.91.0-0.91.10.5-0.80.7-0.20.01.3-0.2
Seeking ratio, delayed vs. immediate footshock0.10.20.70.10.60.20.20.1-0.10.00.3-0.70.4-0.9-0.6-0.3-0.3
Distance traveled before self-admin0.00.10.2-0.20.00.10.10.2-0.10.3-0.0-0.20.00.30.30.50.5
Distance traveled after self-admin0.00.10.40.3-0.1-0.1-0.1-0.30.0-0.2-0.50.3-0.20.10.60.1-0.1
Extensor digitorum longus weight4.317.321.3-4.64.64.44.44.4-4.54.44.0-4.44.2-3.6-3.23.9-3.0
Bone: elastic displacement0.20.20.70.4-0.4-0.4-0.4-0.50.4-0.5-0.00.4-0.3-0.3-0.3-0.9-0.5
Bone: elastic work1.62.13.2-1.41.41.41.41.3-1.31.21.7-1.41.6-1.5-1.80.7-1.7
Bone: endosteal estimation3.99.511.7-3.33.33.23.23.3-3.23.33.0-3.43.4-2.8-2.52.8-2.1
Bone: endosteal perimeter2.66.47.7-2.62.62.62.62.6-2.62.52.6-2.82.8-2.7-2.42.0-2.1
Epididymis fat weight0.00.10.80.1-0.30.30.30.0-0.2-0.00.40.1-0.1-0.3-0.7-0.4-0.9
Delta time in closed arm before/after self-admin0.00.00.20.2-0.30.00.0-0.2-0.0-0.20.10.1-0.40.3-0.2-0.30.0
Delta time in open arm before/after self-admin0.20.20.90.1-0.1-0.6-0.6-0.20.4-0.1-0.60.2-0.11.00.80.30.5
Diff in mean of infusions in LGA sessions0.81.52.41.5-1.5-1.3-1.3-1.31.4-1.4-0.91.2-1.10.60.5-1.51.0
Delay discount exponential model param0.10.10.5-0.70.20.30.30.3-0.30.30.5-0.20.2-0.6-0.50.10.0
Extinction: sum of active levers before priming0.71.12.51.2-0.9-0.8-0.8-1.00.9-0.9-1.20.8-0.81.41.3-0.51.6
Active lever presses in extinction session 61.01.01.71.3-0.9-1.1-1.1-1.11.1-1.1-0.81.0-1.20.30.5-1.20.5
Bone: final force2.54.04.9-2.12.12.12.12.1-2.12.12.2-2.22.1-1.7-1.91.6-1.6
Bone: final moment3.35.46.5-2.52.42.42.42.4-2.42.42.5-2.52.4-1.9-2.21.8-2.0
Food consumed during 24 hour testing period1.12.13.0-1.41.71.51.51.5-1.61.51.5-1.51.4-1.2-1.31.2-1.2
Glucose0.00.10.2-0.40.10.30.30.2-0.20.20.3-0.1-0.0-0.4-0.20.2-0.0
Heart weight2.13.44.0-2.01.82.02.02.0-2.02.01.9-1.61.7-1.9-1.61.6-1.6
Delay discount hyperbolic model param0.00.00.2-0.50.10.00.00.1-0.10.10.2-0.10.1-0.3-0.20.00.2
Intermittent access intake day 1-15 change0.31.72.61.6-1.0-1.3-1.3-1.41.3-1.4-1.51.2-1.51.11.3-1.11.1
Intermittent access intake escalation0.31.62.61.6-1.0-1.2-1.2-1.41.3-1.4-1.41.2-1.51.01.2-1.10.9
Intermittent access intake escalation 20.81.42.41.4-0.8-1.1-1.1-1.11.2-1.0-1.50.9-1.21.41.6-0.51.4
Intermitt. access day 1 inactive lever presses0.00.21.7-0.1-0.5-0.0-0.0-0.2-0.0-0.1-0.40.4-0.51.30.70.20.5
Intermitt. access day 15 inactive lever presses0.00.10.70.20.1-0.2-0.2-0.20.1-0.20.10.1-0.5-0.5-0.3-0.5-0.8
Intermitt. access escalation Index0.10.20.70.5-0.4-0.4-0.4-0.50.4-0.5-0.10.3-0.4-0.5-0.3-0.8-0.8
Intermittent access day 1 total infusions0.30.91.8-1.01.10.90.91.0-0.91.00.9-0.90.9-1.3-0.70.9-0.6
Intermittent access day 15 total infusions0.00.10.4-0.00.60.20.20.2-0.20.2-0.0-0.3-0.1-0.40.20.40.2
Intermittent access terminal intake (last 3 days)0.00.10.20.40.4-0.2-0.2-0.20.2-0.1-0.40.0-0.4-0.40.40.10.5
Intermittent access total infusions0.70.81.9-0.81.40.80.80.9-0.91.00.6-1.10.8-1.1-0.31.1-0.1
Intermittent access day 1 locomotion0.40.62.8-0.70.50.60.60.5-0.50.51.1-0.40.6-1.7-1.3-0.1-0.9
Intermittent access day 15 total locomotion0.10.52.4-0.60.70.40.40.4-0.40.40.8-0.50.5-1.5-0.9-0.0-1.0
Intermittent access total locomotion0.50.52.4-0.60.70.50.50.5-0.50.40.9-0.60.5-1.6-1.1-0.0-0.6
Intermittent access standard deviation0.10.31.30.40.1-0.3-0.3-0.30.4-0.2-0.90.1-0.70.41.10.31.2
Left kidney weight1.29.613.3-3.73.13.43.43.4-3.53.43.0-3.02.8-2.9-2.23.2-1.9
Right kidney weight1.28.310.4-3.23.13.03.03.1-3.13.12.9-2.72.5-3.0-2.42.6-2.4
Cocaine induced anxiety0.20.62.30.5-0.9-0.6-0.6-0.50.6-0.4-0.80.5-0.41.20.9-0.11.5
Post-drug Anxiety0.00.00.1-0.3-0.10.10.10.1-0.10.2-0.1-0.10.20.40.30.40.3
Baseline Anxiety0.10.11.2-0.20.30.20.20.1-0.20.10.3-0.20.0-0.5-0.4-0.1-1.1
Tail length1.26.513.6-2.42.22.22.22.1-2.31.93.1-1.91.9-3.7-3.50.6-3.7
Length with tail3.013.219.7-3.83.73.53.53.5-3.63.44.0-3.53.5-4.4-3.82.3-3.9
Length without tail0.94.76.0-2.32.42.42.42.4-2.32.41.9-2.32.3-1.5-1.22.4-1.4
Times rat made contact with spout0.20.21.20.00.20.20.20.1-0.20.00.50.0-0.0-1.1-0.7-0.4-0.9
Lifetime Intake0.70.81.8-0.91.30.90.90.9-0.91.00.6-1.00.8-1.0-0.21.2-0.1
Liver weight, left2.34.07.5-1.91.82.02.01.7-2.01.62.5-1.81.7-2.5-2.70.6-2.6
Liver weight, right1.22.13.2-1.41.41.51.51.4-1.51.31.7-1.21.2-1.8-1.70.7-1.8
Locomotor activity0.60.91.81.2-1.3-0.8-0.8-0.91.0-0.9-0.91.1-0.91.10.7-0.80.7
Locomotor testing distance0.10.41.00.6-1.0-0.6-0.6-0.60.7-0.6-0.40.7-0.40.70.3-0.60.1
Locomotor testing rearing0.31.22.01.1-1.4-1.0-1.0-1.11.1-1.1-1.21.3-1.01.31.1-0.90.7
Locomotion in novel chamber0.40.61.7-0.50.70.80.80.8-0.70.80.8-1.11.3-0.5-0.70.7-0.3
Locomotion in novel chamber post-restriction0.20.51.01.0-0.7-1.0-1.0-0.70.9-0.8-0.40.6-0.40.60.1-0.90.1
Fecal boli incidents, locomotor time 10.10.41.4-0.40.40.40.40.4-0.50.30.8-0.50.1-0.9-0.9-0.1-1.2
Change in fecal boli incidents, locomotor task0.10.10.60.4-0.2-0.4-0.4-0.40.4-0.5-0.10.10.3-0.2-0.3-0.8-0.1
Time >=10cm from walls, locomotor time 10.20.21.6-0.10.60.10.10.2-0.20.20.1-0.20.3-1.3-0.10.2-0.6
Bouts of movement, locomotor time 10.20.30.80.6-0.5-0.5-0.5-0.60.5-0.6-0.50.4-0.60.90.3-0.50.7
Total resting periods, locomotor time 10.10.10.40.3-0.3-0.2-0.2-0.30.2-0.30.00.2-0.40.2-0.3-0.6-0.0
Rest time, locomotor task time 10.10.10.60.4-0.3-0.2-0.2-0.40.3-0.5-0.00.3-0.6-0.2-0.2-0.70.1
Distance moved, locomotor task time 10.10.41.2-0.60.30.50.50.8-0.50.80.3-0.60.90.70.11.10.3
Vertical activity count, locomotor time 10.00.20.9-0.1-0.0-0.1-0.10.30.00.3-0.2-0.30.31.00.60.70.3
Time >=10cm from walls, locomotor time 20.72.03.8-1.31.51.41.41.3-1.31.21.3-1.11.4-1.9-1.30.9-1.9
Bouts of movement, locomotor time 20.00.00.10.1-0.1-0.2-0.2-0.20.2-0.2-0.10.2-0.00.00.0-0.2-0.0
Total resting periods, locomotor time 20.00.00.10.2-0.2-0.3-0.3-0.20.2-0.3-0.10.2-0.20.20.0-0.3-0.1
Rest time, locomotor task time 20.40.61.11.0-0.7-1.0-1.0-0.81.0-0.9-0.60.4-0.60.50.3-1.00.7
Distance moved, locomotor task time 20.30.41.6-0.1-0.00.30.30.4-0.30.5-0.5-0.10.41.31.11.11.0
Vertical activity count, locomotor time 20.30.62.4-0.90.70.60.60.9-0.71.00.2-0.80.90.60.51.50.2
Light reinforcement 10.73.06.4-2.21.91.91.92.0-1.92.11.1-1.91.7-0.4-0.32.50.2
Light reinforcement 21.02.34.2-2.01.81.51.51.8-1.61.81.2-1.71.4-0.8-0.62.0-0.2
Bone: marrow area3.99.611.8-3.33.33.23.23.3-3.23.33.1-3.43.4-2.8-2.52.8-2.1
Bone: maximum diameter4.28.49.8-3.13.02.92.92.9-3.02.83.1-3.03.0-2.9-2.92.0-3.0
Bone: maximum force3.46.78.1-2.82.72.82.82.8-2.82.82.6-2.82.8-1.8-2.12.5-2.1
Bone: maximum moment4.17.89.2-3.02.93.03.03.0-3.02.92.9-3.03.0-2.0-2.42.5-2.4
Mean time between licks in bursts0.10.50.9-0.91.00.70.70.8-0.70.80.6-0.90.9-0.2-0.40.8-0.0
Mean num. licks in bursts0.10.21.0-0.30.30.40.40.3-0.40.30.4-0.20.3-1.0-0.40.2-0.7
Cd content in liver2.83.24.2-2.11.92.02.01.9-1.91.91.8-1.91.8-1.1-1.51.6-1.3
Co content in liver0.10.10.3-0.20.20.20.20.2-0.30.20.4-0.30.2-0.5-0.6-0.1-0.6
Cu content in liver0.00.00.20.1-0.1-0.2-0.2-0.20.1-0.20.00.1-0.0-0.2-0.2-0.4-0.1
Fe content in liver0.40.52.30.1-0.3-0.2-0.2-0.30.1-0.40.60.2-0.2-1.1-1.2-1.2-1.5
K content in liver1.11.11.41.1-1.2-1.1-1.1-1.11.2-1.2-0.91.1-1.10.70.6-1.20.2
Mg content in liver0.10.10.30.3-0.4-0.4-0.4-0.40.4-0.4-0.20.3-0.40.10.0-0.5-0.2
Mn content in liver0.20.20.5-0.40.40.40.40.4-0.30.30.5-0.30.4-0.6-0.50.1-0.7
Na content in liver1.92.23.21.5-1.8-1.6-1.6-1.61.6-1.7-1.21.6-1.61.00.7-1.80.6
Rb content in liver0.80.91.60.9-1.3-1.0-1.0-1.01.1-1.1-0.81.0-1.10.90.5-1.10.2
Se content in liver1.92.23.51.6-1.7-1.6-1.6-1.71.6-1.7-1.21.7-1.80.50.7-1.90.5
Sr content in liver1.81.52.01.3-1.3-1.3-1.3-1.21.3-1.2-1.31.3-1.21.01.2-0.91.4
Zn content in liver0.10.10.3-0.40.40.40.40.4-0.40.40.2-0.40.4-0.20.00.50.2
Bone: minimum diameter1.83.44.4-2.11.92.02.02.0-2.02.01.7-2.02.0-1.3-1.31.8-1.5
Time in familiar zone, hab. session 11.01.11.4-1.20.91.21.21.2-1.21.11.2-0.81.0-0.9-1.00.9-1.2
Time in novel zone, hab. session 14.04.57.32.0-2.0-2.0-2.0-1.92.1-1.8-2.41.9-2.12.72.5-1.02.7
Total zone transitions, hab. session 18.612.117.03.8-3.8-3.9-3.9-3.93.7-4.0-2.94.0-3.91.61.8-4.11.4
Total locomotion distance, hab. session 15.57.815.53.2-3.0-3.1-3.1-3.33.0-3.4-2.03.1-3.20.40.8-3.90.4
Locomotion velocity, hab. session 14.05.713.42.7-2.4-2.6-2.6-2.82.5-3.0-1.52.6-2.7-0.30.2-3.7-0.2
Time in familiar zone, hab. session 20.10.10.30.10.2-0.1-0.10.00.00.1-0.30.00.10.30.60.40.3
Time in novel zone, hab. session 20.00.00.1-0.1-0.20.10.10.1-0.00.10.1-0.2-0.00.3-0.10.00.3
Total zone transitions, hab. session 24.55.77.22.6-2.5-2.7-2.7-2.52.5-2.5-2.42.5-2.51.82.1-2.12.0
Total locomotion distance, hab. session 21.31.63.61.5-1.2-1.5-1.5-1.51.4-1.6-0.91.2-1.3-0.40.3-1.90.2
Locomotion velocity, hab. session 21.01.43.51.3-1.1-1.3-1.3-1.41.2-1.5-0.71.1-1.2-0.7-0.0-1.9-0.0
Novel to familiar place preference ratio0.40.52.0-0.1-0.30.00.0-0.2-0.0-0.30.80.4-0.2-1.4-1.4-1.1-1.1
Novelty place preference0.50.62.20.3-0.7-0.4-0.4-0.50.4-0.60.50.7-0.5-1.2-1.2-1.5-0.9
Time in novel zone, NPP test0.50.72.40.4-0.8-0.5-0.5-0.60.5-0.80.40.9-0.7-1.1-1.1-1.6-0.7
Total zone transitions, NPP test3.24.75.42.2-2.3-2.3-2.3-2.12.2-2.0-2.32.3-2.32.12.2-1.52.2
Total locomotion distance, NPP test0.60.81.21.1-0.9-1.0-1.0-1.01.0-1.0-1.00.8-0.90.60.8-0.90.9
Locomotion velocity, NPP test0.30.40.70.8-0.6-0.7-0.7-0.80.7-0.8-0.70.5-0.70.30.5-0.70.7
Intraocular pressure1.72.75.0-1.41.61.71.71.7-1.61.61.9-2.02.2-1.0-1.81.2-1.3
Delta distance traveled before/after self-admin0.10.10.30.3-0.0-0.2-0.2-0.30.1-0.3-0.30.5-0.1-0.60.1-0.3-0.3
Delta ambulatory time before/after self-admin0.10.20.30.6-0.2-0.4-0.4-0.60.3-0.6-0.40.6-0.2-0.40.2-0.6-0.3
Parametrial fat weight0.71.74.21.1-1.1-1.4-1.4-1.01.3-0.9-1.61.2-1.01.21.8-0.22.0
Pavlov. Cond. lever latency0.30.41.20.6-0.7-0.6-0.6-0.60.7-0.6-0.70.5-0.51.10.7-0.30.6
Pavlov. Cond. magazine entry latency0.40.52.0-0.20.20.20.20.1-0.2-0.10.8-0.20.1-1.4-1.3-0.7-1.2
Pavlov. Cond. change in total contacts0.10.10.40.4-0.5-0.2-0.2-0.50.4-0.5-0.20.4-0.6-0.20.0-0.60.1
Pavlov. Cond. index score0.20.31.4-0.20.20.30.30.2-0.30.10.7-0.20.1-1.2-1.0-0.4-0.9
Pavlov. Cond. latency score0.40.51.8-0.50.50.50.50.4-0.50.30.9-0.50.4-1.3-1.2-0.2-1.0
Pavlov. Cond. lever contacts0.40.51.7-0.60.60.60.60.5-0.60.50.9-0.50.5-1.3-1.00.1-0.8
Pavlov. Cond. magazine entry number0.40.52.00.4-0.3-0.4-0.4-0.30.4-0.2-0.90.4-0.31.41.30.41.0
Pavlov. Cond. intertrial magazine entries1.82.23.81.4-1.3-1.4-1.4-1.41.5-1.4-1.91.5-1.41.71.9-0.71.3
Pavlov. Cond. lever-magazine prob. diff.0.20.20.9-0.20.10.20.20.1-0.20.00.5-0.1-0.0-1.0-0.8-0.4-0.7
Pavlov. Cond. response bias0.30.42.2-0.30.30.30.30.2-0.40.20.8-0.30.2-1.5-1.1-0.4-0.9
Pavlov. Cond. lever latency0.50.81.20.8-1.1-0.9-0.9-0.90.9-1.0-0.70.9-1.01.10.4-1.00.3
Pavlov. Cond. magazine entry latency0.40.60.80.9-0.7-0.9-0.9-0.90.9-0.9-0.80.8-0.60.20.6-0.80.8
Pavlov. Cond. change in total contacts0.20.40.7-0.50.80.60.60.7-0.60.70.4-0.70.8-0.8-0.10.80.1
Pavlov. Cond. index score0.00.10.5-0.00.30.10.10.1-0.10.20.0-0.10.3-0.70.10.20.2
Pavlov. Cond. latency score0.30.51.4-0.60.80.60.60.6-0.60.60.6-0.70.8-1.2-0.50.6-0.3
Pavlov. Cond. lever contacts0.40.51.0-0.60.90.70.70.8-0.80.80.6-0.80.8-1.0-0.30.8-0.3
Pavlov. Cond. magazine entry number0.20.30.6-0.60.40.50.50.5-0.50.40.7-0.50.2-0.2-0.70.2-0.8
Pavlov. Cond. intertrial magazine entries0.10.11.4-0.10.10.00.0-0.0-0.0-0.10.3-0.0-0.1-0.3-0.5-0.4-1.2
Pavlov. Cond. lever-magazine prob. diff.0.00.10.4-0.00.30.10.10.1-0.10.1-0.0-0.10.2-0.60.10.20.3
Pavlov. Cond. response bias0.00.10.20.20.1-0.0-0.00.00.00.1-0.3-0.00.1-0.30.50.30.5
Time in closed arm before self-admin1.22.13.9-1.61.41.51.51.7-1.61.71.1-1.61.8-0.4-0.52.0-0.7
Time in closed arm after self-admin0.50.60.9-0.70.60.90.90.8-0.90.80.8-0.90.90.0-0.70.7-0.7
Time in open arm before self-admin0.40.52.70.1-0.1-0.0-0.0-0.30.1-0.40.60.2-0.5-1.6-1.3-1.2-0.7
Time in open arm after self-admin0.30.30.50.5-0.3-0.7-0.7-0.60.6-0.6-0.50.6-0.60.10.3-0.60.2
Bone: periosteal estimation5.312.615.8-4.03.83.73.73.7-3.83.73.6-3.83.8-2.9-3.03.2-2.8
Bone: periosteal perimeter5.711.213.0-3.63.43.43.43.4-3.43.33.5-3.53.5-3.3-3.22.6-3.2
Bone: post-yield work0.81.32.7-1.11.11.21.21.2-1.31.21.1-1.11.1-0.8-0.91.0-1.6
Progressive ratio test 1 active lever presses0.20.31.0-0.60.90.50.50.5-0.50.50.5-0.50.4-1.0-0.40.4-0.3
Progressive ratio test 1 breakpoint0.20.30.8-0.60.90.50.50.5-0.50.50.4-0.50.4-0.9-0.30.5-0.2
Progressive ratio test 1 inactive lever presses0.30.91.70.8-0.7-1.2-1.2-1.11.0-1.1-0.91.0-1.30.30.6-1.0-0.0
Progressive ratio test 2 active lever presses0.10.10.3-0.50.50.30.30.4-0.30.40.2-0.40.3-0.00.00.60.1
Progressive ratio test 2 breakpoint0.10.10.3-0.50.50.30.30.4-0.30.40.2-0.40.3-0.00.00.60.1
Progressive ratio test 2 inactive lever presses0.00.10.20.10.1-0.1-0.1-0.20.1-0.20.1-0.0-0.4-0.3-0.3-0.4-0.3
Incentive Sensitization - Responses0.00.10.60.1-0.2-0.3-0.3-0.10.3-0.1-0.20.10.10.80.30.00.5
Incentive Sensitization - Breakpoint0.00.10.5-0.10.0-0.1-0.10.10.10.1-0.0-0.10.30.70.20.20.4
Sum of active levers in priming session hrs 5-60.00.00.20.20.2-0.0-0.00.00.10.0-0.2-0.20.10.50.20.10.2
Progressive ratio0.00.00.2-0.1-0.10.10.10.2-0.10.10.4-0.1-0.1-0.0-0.4-0.0-0.2
Food seeking constrained by brief footshock8.110.114.2-3.53.83.43.43.5-3.43.52.7-3.23.4-2.9-1.83.5-1.9
Seeking ratio, punishment vs. effort0.71.63.0-1.41.71.31.31.3-1.31.40.7-1.21.5-1.0-0.21.7-0.5
Retroperitoneal fat weight1.04.46.71.9-2.1-2.0-2.0-1.82.0-1.7-2.32.2-2.12.62.5-0.82.6
Reaction time number correct0.31.11.9-1.41.01.01.01.2-1.01.11.2-1.21.0-0.7-1.00.9-1.1
Reaction time mean minus median0.31.72.61.6-1.3-1.4-1.4-1.41.4-1.4-1.51.4-1.20.71.3-1.11.1
Reaction time mean minus median AUC0.21.21.51.2-1.1-1.2-1.2-1.11.2-1.1-1.21.2-1.10.61.2-0.81.0
Reaction time num false alarms0.20.40.9-0.80.10.60.60.6-0.60.60.2-0.20.30.90.30.90.8
Reaction time num false alarms AUC0.20.40.9-0.90.30.70.70.7-0.60.70.3-0.40.40.60.11.00.7
Reaction time trials correct on left0.31.11.9-1.41.01.01.01.2-1.01.11.2-1.21.0-0.7-1.00.9-1.1
Reaction time trials on left0.41.32.1-1.51.11.11.11.2-1.11.21.3-1.31.1-0.8-1.20.9-1.2
Reaction time mean0.10.10.7-0.10.40.30.30.3-0.30.30.2-0.50.5-0.8-0.10.4-0.2
Reaction time mean AUC0.10.11.0-0.10.40.20.20.2-0.20.20.2-0.50.4-1.0-0.20.2-0.3
Median of all reaction times0.50.81.6-0.71.00.80.80.9-0.90.90.7-1.11.0-1.3-0.60.8-0.6
Reaction time omissions0.91.53.3-0.91.01.21.21.0-1.20.91.4-1.01.2-1.8-1.60.4-1.5
Reaction time false alarm rate0.20.31.20.2-0.6-0.2-0.2-0.30.3-0.3-0.50.5-0.51.00.6-0.01.1
Reaction time premature initiation rate0.10.10.4-0.20.20.20.20.3-0.20.30.3-0.70.6-0.3-0.30.2-0.2
Reaction time premature initiations0.41.12.0-1.20.91.01.01.1-0.91.11.1-1.41.3-0.8-1.00.9-0.9
Std. dev. reaction times0.20.71.21.1-0.8-0.8-0.8-0.80.8-0.8-1.00.7-0.60.61.0-0.51.0
Reaction time trials completed0.41.32.1-1.51.11.11.11.2-1.11.21.3-1.31.1-0.8-1.20.9-1.2
Reaction time trials AUC0.31.21.9-1.41.11.01.01.2-1.01.21.2-1.21.0-0.7-1.00.9-1.1
Run reversals in cocaine runway, females0.10.10.5-0.10.10.10.10.1-0.20.10.4-0.40.3-0.7-0.5-0.10.0
Run reversals in cocaine runway, males0.40.40.70.6-0.3-0.8-0.8-0.70.8-0.7-0.90.3-0.50.50.8-0.40.2
Latency to leave start box in cocaine runway0.71.03.3-1.00.80.60.60.7-0.80.61.2-1.01.0-1.1-1.50.0-1.8
Latency to leave start box in cocaine runway, F0.40.51.8-0.70.50.60.60.6-0.70.50.9-0.60.8-0.5-1.10.1-1.3
Latency to leave start box in cocaine runway, M0.20.20.9-0.40.3-0.1-0.10.2-0.10.10.5-0.30.3-0.8-0.7-0.2-0.9
Std. dev. time between licks in bursts0.40.71.3-1.11.10.80.80.9-0.80.90.7-1.01.1-0.2-0.60.9-0.3
Total sessions with >9 infusions0.00.00.2-0.00.20.00.00.1-0.10.10.1-0.10.1-0.5-0.10.00.3
Short access day 1 total inactive lever presses0.10.20.80.50.1-0.0-0.0-0.20.2-0.2-0.70.1-0.20.20.90.30.9
Short access day 10 total inactive lever presses0.32.23.61.2-1.6-1.2-1.2-1.41.3-1.3-1.81.5-1.71.81.9-0.71.8
Short access day 1 total infusions0.30.50.70.8-0.7-0.7-0.7-0.80.7-0.7-0.80.7-0.80.40.7-0.60.8
Short access day 10 total infusions0.10.21.0-0.30.60.30.30.3-0.30.40.4-0.40.1-1.0-0.40.2-0.1
Short access total infusions0.10.10.4-0.30.50.40.40.3-0.40.40.2-0.30.2-0.6-0.10.4-0.1
Short access day 1 locomotion0.30.51.60.8-0.7-0.9-0.9-0.80.7-0.9-0.20.7-0.60.1-0.3-1.30.1
Short access day 10 total locomotion0.10.42.0-0.2-0.10.30.30.1-0.1-0.00.9-0.00.1-1.1-1.4-0.8-0.9
Short access total locomotion0.20.31.3-0.10.10.10.10.0-0.1-0.00.7-0.10.0-1.0-1.1-0.7-0.6
One hour access (0.3 mA shock)0.20.20.7-0.30.60.20.20.3-0.20.4-0.2-0.30.2-0.00.70.80.6
Compulsive drug intake0.20.20.90.4-0.4-0.2-0.2-0.10.3-0.1-0.50.3-0.40.90.80.30.7
One hour access (shock baseline)0.10.30.7-0.60.80.50.50.5-0.50.50.4-0.60.6-0.8-0.40.4-0.3
Social response proportion3.14.07.11.8-1.9-2.0-2.0-1.71.9-1.6-2.32.0-1.82.72.5-0.72.4
Social responses0.50.62.7-0.2-0.5-0.3-0.3-0.10.10.0-0.90.4-0.31.61.50.81.3
Social time0.10.20.90.3-0.60.00.0-0.20.2-0.2-0.40.4-0.41.00.60.10.5
Soleus weight2.16.17.7-2.52.52.52.52.4-2.42.32.7-2.52.4-2.8-2.71.5-2.7
Bone: stiffness0.61.01.4-1.11.01.11.11.1-1.21.11.1-1.11.0-0.9-0.90.9-0.8
Tibialis anterior weight6.422.230.3-5.35.45.25.25.3-5.25.44.1-5.15.0-2.7-2.65.5-2.2
Time to tail flick, vehicle, before self-admin0.10.10.40.6-0.4-0.1-0.1-0.30.0-0.3-0.00.4-0.40.2-0.2-0.5-0.6
Time to tail flick, vehicle, after self-admin0.30.62.1-0.60.60.70.70.5-0.70.40.9-0.40.4-1.5-1.1-0.0-1.2
Time to tail flick, test, before self-admin0.40.40.9-0.60.60.80.80.7-0.80.70.4-0.70.90.3-0.20.80.1
Time to tail flick, test, after self-admin1.41.52.3-1.51.11.31.31.3-1.41.31.4-1.21.4-0.8-1.21.0-1.0
Delta time to tail flick, vehicle, before/after SA0.20.20.7-0.60.50.20.20.4-0.30.30.6-0.30.3-0.8-0.70.0-0.6
Delta time to tail flick, test, before/after SA0.20.21.0-0.1-0.2-0.2-0.2-0.10.1-0.20.40.2-0.2-1.0-0.7-0.6-0.7
Tibia length1.43.84.4-2.12.02.02.02.0-2.02.02.0-2.01.9-1.9-1.71.6-2.0
Ambulatory time before self-admin0.10.20.40.4-0.5-0.4-0.4-0.40.5-0.4-0.50.2-0.50.60.5-0.20.7
Ambulatory time after self-admin0.00.00.20.2-0.1-0.2-0.2-0.20.0-0.1-0.40.20.1-0.10.40.1-0.1
Bone: tissue strength0.70.81.80.8-1.0-0.8-0.8-0.80.9-0.8-0.90.8-0.81.30.9-0.60.8
Total heroin consumption0.40.51.6-0.40.30.80.80.6-0.50.51.0-0.70.8-0.8-1.2-0.1-0.5
Bone: trabecular number0.20.41.0-0.40.50.40.40.5-0.40.40.8-0.70.7-0.9-1.0-0.0-0.6
Bone: trabecular spacing0.60.93.2-0.80.81.01.01.0-0.91.10.1-0.80.80.60.71.80.8
Bone: trabecular thickness0.30.52.0-0.20.10.20.20.1-0.2-0.00.9-0.30.3-1.1-1.4-0.7-1.2
Bone: trabecular tissue density3.25.79.52.1-2.3-2.3-2.3-2.22.1-2.0-2.92.4-2.33.03.1-0.92.7
Water consumed over 24 hours1.12.23.1-1.61.51.51.51.4-1.61.41.7-1.31.3-1.7-1.70.8-1.6
Number of responses in last shaping day2.02.53.3-1.51.71.71.71.8-1.81.71.7-1.71.6-0.8-1.31.5-1.6