Hub : Genes

Rnaseh2c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Rnaseh2c	0.05	0.04	1.8e-03	-0	0.02	0.01	0	5.9e-01	1.6e-02	4.2e-02	1.3e-01
2	PL	gene expression	Rnaseh2c	0.02	0.01	9.4e-03	0.02	0.02	0.01	0.02	9.5e-04	7.0e-03	8.7e-03	3.7e-03
3	NAcc	gene expression	Rnaseh2c	0.11	0.06	6.1e-08	0.01	0.03	0.03	0.04	1.8e-03	1.9e-05	6.7e-06	3.0e-06
4	Eye	isoform ratio	NM_001401703.1	0.35	0.18	9.9e-03	0.09	0.04	-0	0.05	1.6e-02	7.6e-02	3.5e-01	6.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.3	2.4	-1.6	1.0	-1.1	-0.7
Area under the delay curve	0.1	0.1	0.3	-0.3	-0.3	0.5	-0.1
BMI with tail	2.3	8.0	16.3	-4.0	2.5	-2.3	-2.1
BMI without tail	0.6	3.0	5.9	-2.4	1.6	-0.9	-1.6
Body weight	2.9	12.7	17.2	-4.1	3.6	-2.8	-3.5
Weight adjusted by age	0.6	1.9	2.7	-1.3	1.4	-1.6	-1.0
Bone surface	5.1	9.9	12.6	-3.5	3.1	-3.5	-2.3
Bone volume	2.2	4.3	6.6	-2.5	1.8	-2.6	-1.0
Breakpoint value in progressive ratio session	2.5	4.5	5.4	-2.2	2.2	-2.3	-1.6
Number of licking bursts	0.2	0.6	1.0	-0.8	0.8	-1.0	-0.4
Context. condit. distance diff. score	2.1	2.5	3.3	1.5	-1.8	1.6	1.3
Locomotion velocity, session 1	0.2	0.2	0.4	0.4	-0.0	0.6	-0.5
Locomotion distance, session 1	0.6	0.8	1.3	-1.1	0.8	-0.3	-1.0
Locomotion velocity, session 2	3.1	3.7	4.4	-2.1	2.0	-1.5	-2.0
Locomotion distance, session 2	0.8	1.2	1.8	-1.3	1.0	-0.4	-1.3
Locomotion velocity, session 3	0.1	0.1	0.2	-0.0	-0.3	0.5	0.2
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.1	0.2	0.1
Stereotopy head waving bouts, day 3	0.7	0.9	1.6	0.5	-1.1	1.3	0.6
Stereotopy head waving duration, day 3	0.8	1.0	1.6	0.7	-1.3	1.0	0.9
Locomotion velocity, session 7	0.1	0.2	0.3	-0.3	-0.5	0.2	0.5
Locomotion distance, session 7	0.1	0.2	0.4	-0.2	-0.1	0.6	-0.4
Stereotopy head waving bouts, day 7	0.3	0.3	0.6	-0.4	-0.1	-0.7	0.8
Stereotopy head waving duration, day 7	1.1	1.3	2.5	-1.4	0.9	-1.6	-0.2
Locomotion velocity, session 8	0.8	0.9	2.2	-0.5	1.1	-0.2	-1.5
Locomotion distance, session 8	0.2	0.2	0.4	0.1	-0.7	0.5	0.4
Degree of sensitization distance	0.1	0.1	0.1	-0.4	-0.0	0.3	-0.4
Degree of sensitization stereotypy	1.0	1.1	2.5	-1.2	0.8	-1.6	0.1
Conditioned locomotion	1.4	1.6	2.0	-1.2	1.4	-1.0	-1.4
Cocaine response after cond. corrected	1.3	1.9	3.4	1.4	-1.3	1.8	0.8
Cocaine response after cond. not corrected	0.9	1.4	2.1	1.2	-1.1	1.5	0.8
Cocaine response before conditioning	1.0	1.2	2.5	-1.1	1.0	-1.6	-0.4
Saline control response	3.6	4.9	6.5	-2.1	2.6	-1.5	-2.5
Bone: connectivity density	2.8	4.5	6.5	-2.6	2.1	-1.9	-1.8
Bone: cortical apparent density	0.0	0.1	0.1	-0.1	0.4	-0.2	-0.3
Bone: cortical area	0.9	1.4	2.1	-1.1	1.3	-1.5	-0.9
Bone: cortical porosity	0.2	0.2	0.4	-0.6	0.3	-0.2	-0.5
Bone: cortical porosity	0.5	0.6	0.9	-1.0	0.7	-0.4	-0.9
Bone: cortical thickness	2.6	4.4	6.9	-1.5	2.6	-1.5	-2.4
Bone: cortical thickness	0.5	0.7	1.5	-0.2	1.0	0.3	-1.2
Bone: cortical tissue density	0.1	0.2	0.3	-0.2	0.5	-0.3	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.6	0.5	-0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	0.1	-0.2	-0.1
Condit. Reinf. active responses	0.2	0.2	0.4	-0.6	0.4	-0.6	0.0
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.3	-0.0	-0.3	0.4
Incentive salience index mean	0.4	0.6	1.1	-1.0	0.7	-0.6	-0.5
Condit. Reinf. lever presses	0.6	1.0	1.5	-1.2	0.9	-1.1	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	-0.1	-0.1	-0.7	0.6
Condit. Reinf. active-inactive response ratio	0.5	0.7	2.1	0.3	-0.7	-0.6	1.4
Condit. Reinf. active responses	0.3	0.4	0.8	-0.8	0.5	-0.9	-0.1
Condit. Reinf. inactive responses	0.5	0.7	1.2	-1.0	0.8	-0.2	-1.1
Condit. Reinf. lever presses	2.7	3.9	6.3	-2.0	2.0	-2.5	-1.1
Condit. Reinf. lever reinforcers received	0.6	0.8	1.5	-1.0	0.8	-1.2	-0.4
Conditioned reinforcement - actives	0.2	0.6	2.2	0.0	0.1	-1.5	0.6
Conditioned reinforcement - inactives	1.3	3.5	7.1	1.8	-1.8	0.1	2.7
Conditioned locomotion	6.3	9.3	12.8	3.2	-3.3	1.8	3.6
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.0	-0.3	0.1	0.0
Patch foraging indifference point AUC	1.5	3.5	4.6	-1.7	2.0	-2.1	-1.4
Delay disc. indifference point, 0s delay	0.5	0.6	1.3	0.2	-1.0	1.1	0.2
Delay disc. indifference point, 16s delay	0.3	0.5	1.1	0.3	-0.8	0.4	1.0
Delay disc. indifference point, 2s delay	0.0	0.1	0.1	0.1	-0.1	0.2	0.4
Delay disc. indifference point, 24s delay	0.2	0.3	0.8	0.5	-0.5	0.9	-0.2
Delay disc. indifference point, 4s delay	0.3	0.3	1.1	0.1	-0.4	1.1	-0.2
Delay disc. indifference point, 8s delay	0.2	0.3	0.7	-0.0	-0.5	0.8	-0.3
Indifference point function ln k	4.1	12.5	16.6	3.5	-3.7	4.1	2.7
Indifference point function log k	4.1	12.5	16.6	3.5	-3.7	4.1	2.7
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	0.2	-0.2	0.4	-0.2
Patch foraging total patch changes 12 sec	4.9	6.5	7.4	-2.7	2.7	-2.3	-2.4
Patch foraging total patch changes 18 sec	0.5	1.1	1.4	-1.2	1.0	-1.1	-0.8
Patch foraging total patch changes 24 sec	0.7	2.5	3.2	-1.3	1.6	-1.5	-1.8
Patch foraging total patch changes 6 sec	1.1	1.8	2.4	-1.3	1.5	-0.9	-1.6
Patch foraging time to switch 0 sec	1.0	3.8	6.8	-2.6	1.6	-2.2	-1.0
Patch foraging water rate 0 sec	2.1	7.9	12.0	3.5	-2.7	2.7	2.2
Patch foraging water rate 12 sec	4.3	17.2	23.8	4.9	-3.9	4.6	2.9
Patch foraging water rate 18 sec	2.4	5.3	7.7	2.7	-2.1	2.8	1.5
Patch foraging water rate 24 sec	5.5	7.8	10.9	3.3	-2.7	3.0	2.0
Patch foraging water rate 6 sec	5.6	8.3	12.1	3.5	-2.5	3.5	1.6
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.2	-0.3	0.1	0.4
Distance traveled before self-admin	0.6	1.3	2.4	-1.3	0.9	-1.5	-0.4
Distance traveled after self-admin	0.2	0.4	0.7	-0.6	0.5	-0.8	-0.3
Extensor digitorum longus weight	7.6	30.1	35.2	-5.7	5.9	-4.7	-5.5
Bone: elastic displacement	1.4	1.7	3.1	1.8	-0.9	1.7	0.3
Bone: elastic work	0.9	1.1	2.7	-0.4	1.2	0.1	-1.7
Bone: endosteal estimation	0.4	1.0	2.0	0.4	-1.4	0.6	1.3
Bone: endosteal perimeter	0.6	1.4	3.2	0.4	-1.5	0.1	1.8
Epididymis fat weight	2.0	10.1	13.6	3.1	-3.7	2.0	3.6
Delta time in closed arm before/after self-admin	0.6	0.6	1.2	0.0	0.4	0.9	-1.1
Delta time in open arm before/after self-admin	0.6	0.7	2.2	-0.6	0.3	-1.5	0.3
Diff in mean of infusions in LGA sessions	0.4	0.8	1.5	-0.6	1.2	-0.7	-0.8
Delay discount exponential model param	0.1	0.1	0.2	0.3	0.2	-0.5	0.2
Extinction: sum of active levers before priming	2.4	3.6	5.0	-2.2	2.0	-1.8	-1.5
Active lever presses in extinction session 6	3.7	3.7	5.9	-1.8	1.9	-2.4	-1.4
Bone: final force	2.5	4.1	4.6	-2.1	2.1	-2.1	-1.8
Bone: final moment	2.3	3.8	4.2	-2.0	2.1	-1.9	-1.7
Food consumed during 24 hour testing period	0.1	0.1	0.5	0.2	0.2	-0.7	0.1
Glucose	2.0	3.1	4.6	1.2	-2.1	1.7	1.9
Heart weight	1.0	1.6	3.9	0.6	-1.4	2.0	0.5
Delay discount hyperbolic model param	0.1	0.1	0.2	0.3	0.2	-0.4	0.1
Intermittent access intake day 1-15 change	0.3	1.6	2.7	1.4	-1.3	0.0	1.6
Intermittent access intake escalation	0.3	1.4	2.4	1.3	-1.2	-0.2	1.6
Intermittent access intake escalation 2	0.8	1.3	2.1	1.2	-1.2	-0.1	1.5
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.3	0.4	-0.5	0.1	0.6
Intermitt. access day 15 inactive lever presses	0.3	1.8	4.7	1.1	-1.2	-0.1	2.2
Intermitt. access escalation Index	1.1	3.6	4.4	1.8	-2.0	2.1	1.7
Intermittent access day 1 total infusions	0.7	2.1	4.6	0.8	-1.7	0.4	2.1
Intermittent access day 15 total infusions	2.2	5.4	11.0	2.2	-2.4	0.4	3.3
Intermittent access terminal intake (last 3 days)	2.5	4.3	9.5	1.7	-2.2	0.0	3.1
Intermittent access total infusions	2.4	2.8	6.7	1.3	-1.7	0.1	2.6
Intermittent access day 1 locomotion	0.9	1.6	3.3	0.9	-1.5	0.5	1.8
Intermittent access day 15 total locomotion	1.1	4.3	10.3	1.7	-2.1	-0.2	3.2
Intermittent access total locomotion	4.9	5.9	13.4	1.8	-2.6	0.1	3.7
Intermittent access standard deviation	0.3	1.7	2.5	1.6	-1.3	0.5	1.6
Left kidney weight	0.3	2.5	4.4	1.2	-2.1	0.9	1.9
Right kidney weight	0.2	1.5	2.1	1.2	-1.4	0.8	1.3
Cocaine induced anxiety	0.1	0.1	0.5	-0.3	0.1	-0.7	0.1
Post-drug Anxiety	0.7	0.8	1.1	-1.0	0.8	-1.1	-0.7
Baseline Anxiety	0.2	0.4	0.9	-0.3	0.6	0.3	-1.0
Tail length	0.2	1.2	3.0	-0.5	1.2	-0.3	-1.7
Length with tail	1.5	6.6	10.8	-2.1	2.9	-1.6	-3.3
Length without tail	1.0	5.2	9.6	-1.7	2.6	-1.1	-3.1
Times rat made contact with spout	0.5	0.6	1.0	-0.7	0.8	-0.3	-1.0
Lifetime Intake	1.5	1.9	4.3	1.1	-1.4	0.3	2.1
Liver weight, left	1.1	1.8	2.8	1.5	-1.3	1.7	0.8
Liver weight, right	2.8	4.9	7.9	2.3	-2.2	2.8	1.2
Locomotor activity	2.6	4.1	6.9	2.5	-1.6	2.6	1.0
Locomotor testing distance	2.3	5.7	10.4	2.9	-1.8	3.2	1.0
Locomotor testing rearing	1.4	5.0	9.3	2.6	-1.7	3.0	1.1
Locomotion in novel chamber	4.4	5.9	7.8	2.5	-2.8	1.5	2.7
Locomotion in novel chamber post-restriction	1.1	3.3	5.2	1.8	-1.9	1.0	2.3
Fecal boli incidents, locomotor time 1	0.2	0.4	1.1	-0.3	0.2	-1.0	0.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	0.1	-0.2	0.9	-0.6
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.9	-0.1	-0.9	-0.5	1.4
Bouts of movement, locomotor time 1	1.3	1.6	2.4	-1.3	1.2	-1.6	-1.0
Total resting periods, locomotor time 1	1.1	1.3	2.2	-1.2	1.0	-1.5	-0.7
Rest time, locomotor task time 1	1.0	1.6	2.1	1.4	-1.3	0.8	1.4
Distance moved, locomotor task time 1	0.1	0.2	0.6	-0.8	0.4	-0.4	-0.4
Vertical activity count, locomotor time 1	0.1	1.0	1.1	1.0	-1.1	1.0	1.0
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.9	-0.5	-0.1	-1.0	0.3
Bouts of movement, locomotor time 2	0.2	0.6	0.9	-0.9	0.7	-0.8	-0.7
Total resting periods, locomotor time 2	0.1	0.3	0.6	-0.7	0.4	-0.7	-0.4
Rest time, locomotor task time 2	1.6	2.6	3.8	1.6	-1.9	1.3	1.6
Distance moved, locomotor task time 2	1.0	1.3	1.6	-1.0	1.2	-1.0	-1.2
Vertical activity count, locomotor time 2	0.1	0.3	0.6	0.8	-0.0	0.6	-0.3
Light reinforcement 1	0.0	0.2	0.5	0.6	-0.2	0.7	0.1
Light reinforcement 2	0.4	1.0	2.4	0.8	-0.9	-0.1	1.5
Bone: marrow area	0.5	1.1	2.2	0.4	-1.5	0.7	1.3
Bone: maximum diameter	0.3	0.6	2.0	-0.6	0.5	-1.4	-0.1
Bone: maximum force	3.6	7.0	9.2	-3.0	2.7	-2.8	-2.0
Bone: maximum moment	3.4	6.3	8.3	-2.9	2.5	-2.7	-1.9
Mean time between licks in bursts	0.1	0.7	1.7	-0.0	0.6	0.8	-1.3
Mean num. licks in bursts	0.1	0.4	0.9	0.6	-0.6	0.9	0.1
Cd content in liver	1.1	1.2	2.7	0.9	-1.1	-0.1	1.7
Co content in liver	2.2	2.6	4.4	2.0	-1.4	2.1	0.6
Cu content in liver	0.1	0.1	0.2	-0.4	0.1	-0.2	0.2
Fe content in liver	0.1	0.1	0.2	-0.0	0.5	-0.1	-0.4
K content in liver	0.5	0.5	0.8	-0.9	0.7	-0.2	-0.9
Mg content in liver	0.4	0.4	1.0	0.4	-0.6	1.0	0.3
Mn content in liver	3.7	4.2	5.6	-2.0	2.2	-2.4	-1.5
Na content in liver	0.3	0.3	0.4	-0.2	0.7	-0.5	-0.6
Rb content in liver	2.0	2.3	3.4	1.4	-1.5	1.8	1.2
Se content in liver	0.2	0.3	0.7	0.2	-0.2	-0.6	0.9
Sr content in liver	2.4	2.1	2.5	-1.1	1.6	-1.5	-1.6
Zn content in liver	0.2	0.3	0.4	-0.7	0.5	-0.3	-0.6
Bone: minimum diameter	0.4	0.7	1.7	-0.1	-1.1	0.2	1.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.2	-0.3	0.3	0.5
Time in novel zone, hab. session 1	0.6	0.7	1.3	1.0	-0.6	1.1	-0.1
Total zone transitions, hab. session 1	0.9	1.2	1.6	-1.3	1.1	-1.1	-0.9
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.1	-0.7	0.4	0.6
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.3	-0.2	-0.0	0.2
Time in familiar zone, hab. session 2	0.4	0.4	0.9	0.6	-0.0	1.0	-0.5
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.7	0.2	-0.6	0.1
Total zone transitions, hab. session 2	1.7	2.2	4.2	-2.1	1.3	-1.0	-1.4
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.6	-0.2	0.3	-0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.5	-0.4	0.2	0.2
Novel to familiar place preference ratio	1.4	1.8	3.7	-1.5	1.1	-1.9	-0.3
Novelty place preference	0.8	1.0	2.2	-1.1	0.7	-1.5	0.0
Time in novel zone, NPP test	0.6	0.7	1.5	-0.9	0.6	-1.2	-0.0
Total zone transitions, NPP test	2.4	3.6	5.0	-2.2	1.8	-1.7	-1.8
Total locomotion distance, NPP test	0.1	0.2	0.5	-0.7	0.1	-0.0	-0.4
Locomotion velocity, NPP test	0.2	0.2	0.7	-0.8	0.3	-0.2	-0.3
Intraocular pressure	1.2	2.0	3.6	1.5	-1.5	-0.1	1.9
Delta distance traveled before/after self-admin	0.5	0.5	1.3	0.8	-0.3	1.2	-0.1
Delta ambulatory time before/after self-admin	0.2	0.4	1.0	0.6	-0.1	1.0	-0.4
Parametrial fat weight	3.3	7.8	11.5	2.2	-3.4	1.9	3.3
Pavlov. Cond. lever latency	0.3	0.4	0.7	0.9	-0.6	0.5	0.5
Pavlov. Cond. magazine entry latency	0.5	0.6	1.5	-1.2	0.4	-0.9	-0.1
Pavlov. Cond. change in total contacts	0.6	0.7	1.5	-1.0	0.3	-1.2	0.4
Pavlov. Cond. index score	0.3	0.4	0.7	-0.8	0.5	-0.8	-0.1
Pavlov. Cond. latency score	0.2	0.2	0.5	-0.7	0.3	-0.4	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.6	0.3	-0.1	-0.3
Pavlov. Cond. magazine entry number	0.4	0.6	1.2	0.8	-0.6	1.1	0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.2	0.8	-0.4	-0.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.2	-1.1	0.6	-1.0	-0.2
Pavlov. Cond. response bias	0.3	0.4	0.7	-0.7	0.5	-0.9	-0.0
Pavlov. Cond. lever latency	0.9	1.2	2.6	1.0	-1.0	1.6	0.3
Pavlov. Cond. magazine entry latency	4.6	6.5	8.1	-2.8	2.7	-2.6	-2.0
Pavlov. Cond. change in total contacts	1.7	4.2	8.5	-2.2	1.8	-2.9	-0.5
Pavlov. Cond. index score	3.0	4.7	7.2	-2.4	2.2	-2.7	-1.1
Pavlov. Cond. latency score	2.6	4.1	6.7	-2.2	2.0	-2.6	-1.0
Pavlov. Cond. lever contacts	0.8	1.2	2.6	-1.0	1.1	-1.6	-0.3
Pavlov. Cond. magazine entry number	8.1	10.5	12.5	3.5	-3.4	3.5	2.4
Pavlov. Cond. intertrial magazine entries	0.7	1.6	1.9	1.3	-1.4	1.0	1.3
Pavlov. Cond. lever-magazine prob. diff.	3.6	5.5	8.0	-2.6	2.4	-2.8	-1.3
Pavlov. Cond. response bias	2.7	3.7	5.4	-2.1	1.9	-2.3	-1.1
Time in closed arm before self-admin	0.2	0.4	1.0	0.1	-0.8	-0.4	1.0
Time in closed arm after self-admin	0.3	0.3	0.6	0.5	-0.6	0.8	0.3
Time in open arm before self-admin	1.2	1.5	4.7	0.9	-0.2	2.2	-0.7
Time in open arm after self-admin	0.1	0.1	0.3	0.0	0.2	0.3	-0.5
Bone: periosteal estimation	0.1	0.2	0.6	-0.5	-0.0	-0.8	0.3
Bone: periosteal perimeter	0.3	0.5	1.1	-0.8	0.4	-1.0	-0.1
Bone: post-yield work	2.0	3.4	7.6	-2.8	0.9	-2.3	-0.0
Progressive ratio test 1 active lever presses	0.2	0.3	0.7	0.3	-0.2	-0.5	0.9
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	0.2	-0.1	-0.7	0.8
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.2	-0.1	-0.4	0.6
Progressive ratio test 2 active lever presses	1.5	2.2	5.1	1.3	-1.4	-0.2	2.3
Progressive ratio test 2 breakpoint	1.7	2.2	5.1	1.3	-1.3	-0.2	2.3
Progressive ratio test 2 inactive lever presses	2.6	8.3	15.3	2.7	-3.1	1.0	3.9
Incentive Sensitization - Responses	0.1	0.2	0.6	-0.4	0.1	-0.8	0.4
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	-0.2	-0.1	-0.6	0.6
Sum of active levers in priming session hrs 5-6	2.2	2.1	5.7	-0.5	1.5	-2.4	-0.1
Progressive ratio	0.7	2.0	4.3	-2.1	0.9	-1.6	-0.7
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.1	0.4	0.0	-0.4
Seeking ratio, punishment vs. effort	1.3	2.9	5.3	2.2	-1.1	2.3	0.6
Retroperitoneal fat weight	9.0	40.4	46.8	6.3	-6.8	5.9	6.3
Reaction time number correct	0.1	0.2	0.4	-0.1	0.6	-0.1	-0.6
Reaction time mean minus median	0.9	5.6	8.8	-2.6	2.1	-3.0	-1.7
Reaction time mean minus median AUC	0.4	2.6	4.0	-1.6	1.5	-2.0	-1.3
Reaction time num false alarms	0.6	1.0	3.0	1.0	-0.4	1.7	-0.0
Reaction time num false alarms AUC	0.2	0.5	1.4	0.3	0.2	1.2	-0.6
Reaction time trials correct on left	0.1	0.2	0.4	-0.1	0.6	-0.1	-0.6
Reaction time trials on left	0.1	0.3	0.5	-0.2	0.7	-0.2	-0.7
Reaction time mean	0.2	0.4	1.2	-0.5	-0.1	-1.1	0.3
Reaction time mean AUC	0.2	0.4	1.2	-0.6	-0.1	-1.1	0.4
Median of all reaction times	0.2	0.3	0.7	0.0	-0.6	-0.4	0.8
Reaction time omissions	1.6	2.6	3.3	-1.8	1.6	-1.8	-1.3
Reaction time false alarm rate	0.4	0.6	1.8	0.6	-0.4	1.3	0.0
Reaction time premature initiation rate	2.0	3.1	7.5	-1.3	1.8	-0.2	-2.7
Reaction time premature initiations	1.5	4.6	9.9	-1.5	2.4	-0.6	-3.1
Std. dev. reaction times	0.5	1.7	3.3	-1.4	0.9	-1.8	-0.7
Reaction time trials completed	0.1	0.3	0.5	-0.2	0.7	-0.2	-0.7
Reaction time trials AUC	0.0	0.2	0.4	-0.0	0.5	0.1	-0.6
Run reversals in cocaine runway, females	0.6	0.6	1.1	-0.9	0.4	0.7	-1.1
Run reversals in cocaine runway, males	0.6	0.6	1.7	1.3	-0.5	0.7	0.5
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.4	-0.1	-0.3	0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.4	-0.0	-0.3	0.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	0.2	-0.3	0.0
Std. dev. time between licks in bursts	0.4	0.7	1.9	0.7	-0.2	1.4	-0.6
Total sessions with >9 infusions	0.1	0.2	0.3	-0.5	0.2	-0.5	0.1
Short access day 1 total inactive lever presses	1.2	2.5	2.8	1.5	-1.6	1.5	1.7
Short access day 10 total inactive lever presses	0.1	0.7	1.4	0.8	-0.7	1.2	0.6
Short access day 1 total infusions	0.6	1.2	2.0	0.8	-1.2	0.8	1.4
Short access day 10 total infusions	0.2	0.4	0.9	-0.5	-0.2	-0.6	0.9
Short access total infusions	0.1	0.2	0.5	0.0	-0.3	0.0	0.7
Short access day 1 locomotion	0.7	1.1	2.3	0.9	-1.0	0.5	1.5
Short access day 10 total locomotion	0.2	0.8	2.0	0.4	-0.9	-0.1	1.4
Short access total locomotion	0.6	0.9	2.4	0.7	-1.0	0.1	1.5
One hour access (0.3 mA shock)	5.7	6.8	9.6	2.7	-2.8	1.6	3.1
Compulsive drug intake	1.2	1.8	4.7	-0.6	1.3	0.7	-2.2
One hour access (shock baseline)	2.8	7.3	13.9	2.5	-2.9	0.8	3.7
Social response proportion	0.6	0.7	1.2	-0.9	0.8	-1.1	-0.5
Social responses	0.1	0.2	0.4	-0.2	0.6	-0.3	-0.5
Social time	0.2	0.3	0.6	-0.2	0.6	-0.1	-0.8
Soleus weight	4.2	12.4	14.8	3.6	-3.9	3.2	3.4
Bone: stiffness	2.8	5.1	7.0	-2.7	2.1	-2.6	-1.4
Tibialis anterior weight	9.4	32.4	40.5	-5.3	6.4	-5.3	-5.7
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.5	-0.7	0.3	-0.7	-0.3
Time to tail flick, vehicle, after self-admin	0.4	0.7	1.6	-1.3	0.5	-0.2	-1.0
Time to tail flick, test, before self-admin	1.4	1.6	2.3	0.9	-1.4	1.5	1.2
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.1	0.0	-0.6	0.0
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	-0.7	0.5	0.0	-0.8
Delta time to tail flick, test, before/after SA	1.1	1.3	2.7	-0.5	1.2	-1.6	-1.0
Tibia length	1.5	4.2	10.3	-1.7	1.9	-3.2	-0.5
Ambulatory time before self-admin	0.4	1.3	3.0	-1.2	0.7	-1.7	-0.0
Ambulatory time after self-admin	0.1	0.2	0.6	-0.1	-0.5	-0.3	0.8
Bone: tissue strength	0.0	0.0	0.1	-0.2	0.1	-0.3	-0.0
Total heroin consumption	5.5	6.5	7.7	-2.6	2.8	-2.3	-2.4
Bone: trabecular number	1.1	2.1	3.3	-1.8	1.3	-1.8	-0.7
Bone: trabecular spacing	0.7	1.0	2.2	1.1	-0.8	1.5	0.3
Bone: trabecular thickness	0.1	0.2	0.5	0.1	-0.5	0.2	0.7
Bone: trabecular tissue density	3.5	6.2	7.6	2.6	-2.6	1.8	2.8
Water consumed over 24 hours	0.6	1.2	1.8	-0.9	1.3	-0.8	-1.3
Number of responses in last shaping day	0.1	0.1	0.4	0.4	-0.1	0.6	-0.1