Hub : Genes

LOC102549294

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	mRNA stability	LOC102549294	0.56	0.2	5.4e-03	0.04	0.04	0.02	0.05	9.7e-02	8.5e-02	1.4e-01	6.2e-02
2	Brain	mRNA stability	LOC102549294	0.04	0.03	2.1e-03	0.01	0.03	0.02	0	3.0e-02	1.7e-03	2.5e-03	2.4e-01
3	LHb	gene expression	LOC102549294	0.21	0.16	1.1e-03	0.12	0.14	0.13	0.16	1.1e-03	3.7e-04	5.7e-04	1.5e-04
4	Adipose	mRNA stability	LOC102549294	0.06	0.04	4.1e-06	0.04	0.05	0.05	0.04	1.5e-05	3.6e-06	3.7e-06	9.3e-06
5	Adipose	gene expression	LOC102549294	0.05	0.04	2.4e-05	0.03	0.03	0.02	0.03	4.2e-04	1.2e-04	3.4e-03	7.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.6	4.4	8.0	-2.7	-2.8	-2.1	-1.1	1.1
Area under the delay curve	1.1	1.2	2.4	1.5	1.6	0.9	0.4	-0.5
BMI with tail	0.5	1.5	4.3	-2.1	-1.7	-0.5	-0.4	0.2
BMI without tail	0.3	0.5	0.8	-0.3	-0.8	-0.7	-0.9	0.8
Body weight	1.6	6.6	8.7	-1.1	-2.6	-2.9	-2.9	2.8
Weight adjusted by age	0.4	0.4	1.0	-1.0	-0.9	-0.3	-0.2	0.2
Bone surface	1.7	3.1	8.1	-2.8	-2.3	-1.1	-0.6	0.4
Bone volume	2.0	3.3	8.4	-2.9	-2.4	-1.3	-0.6	0.5
Breakpoint value in progressive ratio session	1.4	1.6	2.4	-0.4	-1.2	-1.4	-1.5	1.5
Number of licking bursts	0.2	0.2	0.6	0.6	0.8	0.1	0.3	-0.2
Context. condit. distance diff. score	1.1	1.4	2.4	-1.1	-1.6	-1.3	-0.7	0.9
Locomotion velocity, session 1	3.0	3.3	4.8	-1.3	-2.2	-2.1	-1.7	1.7
Locomotion distance, session 1	0.3	0.4	1.3	-1.2	-0.7	-0.3	-0.1	-0.0
Locomotion velocity, session 2	0.4	0.5	0.9	-0.9	-1.0	-0.6	-0.4	0.4
Locomotion distance, session 2	0.8	1.1	3.2	-1.8	-1.4	-0.6	-0.3	0.2
Locomotion velocity, session 3	2.6	3.1	6.3	2.5	2.5	1.6	0.4	-0.6
Locomotion distance, session 3	0.4	0.4	1.0	-0.3	0.3	1.0	0.5	-0.7
Stereotopy head waving bouts, day 3	0.4	0.4	0.7	0.6	-0.1	-0.7	-0.8	0.8
Stereotopy head waving duration, day 3	0.2	0.2	0.5	0.4	0.7	0.3	0.4	-0.4
Locomotion velocity, session 7	0.5	0.6	1.8	-1.3	-1.0	0.1	0.1	-0.2
Locomotion distance, session 7	0.8	1.1	3.1	-1.8	-1.5	-0.4	-0.1	0.0
Stereotopy head waving bouts, day 7	0.6	0.6	0.9	-0.8	-1.0	-0.8	-0.7	0.6
Stereotopy head waving duration, day 7	0.7	0.9	1.3	-1.1	-1.1	-0.9	-0.8	0.7
Locomotion velocity, session 8	0.2	0.3	0.9	-0.9	-0.6	-0.0	0.1	-0.2
Locomotion distance, session 8	1.6	2.4	3.9	-1.6	-2.0	-1.6	-1.3	1.2
Degree of sensitization distance	1.3	1.3	2.1	-0.8	-1.4	-1.5	-0.9	1.0
Degree of sensitization stereotypy	1.1	1.2	1.7	-0.9	-1.3	-1.2	-1.0	1.0
Conditioned locomotion	0.4	0.4	0.7	0.4	0.6	0.6	0.9	-0.7
Cocaine response after cond. corrected	0.5	0.5	0.9	0.2	-0.6	-0.8	-0.8	1.0
Cocaine response after cond. not corrected	0.7	0.8	1.3	-0.1	-0.9	-0.9	-1.0	1.1
Cocaine response before conditioning	0.5	0.6	1.4	-1.2	-1.0	-0.4	-0.6	0.4
Saline control response	0.3	0.3	1.3	-1.1	-0.5	0.2	0.1	-0.2
Bone: connectivity density	3.3	5.1	10.9	-3.3	-3.1	-1.8	-0.9	0.9
Bone: cortical apparent density	0.5	0.7	1.4	-0.0	0.6	0.8	1.2	-1.0
Bone: cortical area	1.2	1.9	3.2	1.6	1.8	1.5	0.8	-0.9
Bone: cortical porosity	0.1	0.1	0.1	-0.3	-0.4	-0.3	-0.3	0.3
Bone: cortical porosity	0.0	0.0	0.0	0.1	0.0	0.0	-0.2	0.1
Bone: cortical thickness	2.9	4.7	10.8	3.3	3.0	1.8	0.6	-0.7
Bone: cortical thickness	0.6	0.7	2.4	1.6	0.9	0.0	-0.5	0.5
Bone: cortical tissue density	0.4	0.5	1.1	-0.1	0.5	0.6	1.0	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	0.8	0.2	-0.0	-0.4	0.4
Condit. Reinf. active-inactive response ratio	1.5	1.6	5.0	2.2	1.0	0.0	-1.0	0.9
Condit. Reinf. active responses	0.1	0.2	0.4	-0.5	-0.6	-0.2	-0.1	0.1
Condit. Reinf. inactive responses	2.0	2.4	7.5	-2.7	-1.4	-0.1	1.2	-1.0
Incentive salience index mean	0.3	0.3	0.6	0.7	-0.1	-0.2	-0.8	0.7
Condit. Reinf. lever presses	0.9	1.2	2.1	0.1	-1.0	-0.9	-1.4	1.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	-0.7	-0.6	-0.2	-0.2	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.5	0.0	-0.2	-0.4	0.5
Condit. Reinf. active responses	0.4	0.6	2.1	-1.5	-0.7	0.2	0.3	-0.5
Condit. Reinf. inactive responses	1.6	2.0	5.9	-2.4	-0.7	0.6	1.1	-1.4
Condit. Reinf. lever presses	1.1	1.5	2.3	-0.3	1.0	1.5	1.3	-1.5
Condit. Reinf. lever reinforcers received	0.4	0.6	2.0	-1.4	-0.5	0.4	0.5	-0.7
Conditioned reinforcement - actives	1.2	1.2	3.8	-1.9	-1.4	-0.4	0.3	-0.2
Conditioned reinforcement - inactives	0.3	0.4	1.1	-1.0	-0.7	0.1	0.4	-0.4
Conditioned locomotion	0.4	0.5	1.1	0.0	0.7	1.1	0.6	-0.8
Patch foraging indifference point 0 sec	0.1	0.1	0.4	-0.6	-0.4	0.3	0.0	-0.2
Patch foraging indifference point AUC	0.6	0.7	1.3	-0.1	0.6	0.9	1.2	-1.1
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.1	0.0	-0.1	-0.2	0.1
Delay disc. indifference point, 16s delay	0.5	0.5	1.2	0.9	1.1	0.5	0.4	-0.4
Delay disc. indifference point, 2s delay	0.8	0.9	2.1	1.2	1.4	0.7	0.4	-0.5
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	0.5	0.6	0.5	0.2	-0.3
Delay disc. indifference point, 4s delay	0.6	0.6	2.0	1.4	1.1	0.2	-0.1	0.1
Delay disc. indifference point, 8s delay	0.5	0.5	1.3	1.1	1.0	0.5	0.1	-0.1
Indifference point function ln k	0.4	0.5	1.0	-0.9	-1.0	-0.5	-0.5	0.4
Indifference point function log k	0.4	0.5	1.0	-0.9	-1.0	-0.5	-0.5	0.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.6	-0.7	-0.3	0.3	0.2	-0.3
Patch foraging total patch changes 12 sec	0.3	0.4	0.8	0.9	0.9	0.8	0.2	-0.3
Patch foraging total patch changes 18 sec	0.4	0.6	1.4	1.2	1.1	0.5	0.0	-0.1
Patch foraging total patch changes 24 sec	0.8	1.0	1.7	0.8	1.2	1.3	0.7	-0.8
Patch foraging total patch changes 6 sec	0.6	0.9	1.4	-0.2	0.7	1.2	1.0	-1.2
Patch foraging time to switch 0 sec	0.8	1.3	3.3	1.8	0.9	-0.5	-1.0	1.0
Patch foraging water rate 0 sec	0.5	0.9	1.5	-1.2	-0.2	0.7	1.0	-1.1
Patch foraging water rate 12 sec	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.0	0.0
Patch foraging water rate 18 sec	1.6	2.1	5.2	-2.3	-1.9	-1.3	-0.4	0.4
Patch foraging water rate 24 sec	0.2	0.3	0.7	-0.9	-0.2	0.3	0.5	-0.6
Patch foraging water rate 6 sec	0.4	0.6	0.9	-0.0	0.6	1.0	0.9	-1.0
Seeking ratio, delayed vs. immediate footshock	2.0	2.3	3.5	0.7	1.8	1.9	1.4	-1.6
Distance traveled before self-admin	1.4	1.5	2.8	1.3	1.7	1.3	0.8	-0.9
Distance traveled after self-admin	0.1	0.1	0.3	0.5	0.1	0.0	-0.3	0.3
Extensor digitorum longus weight	2.6	10.4	30.4	-5.5	-4.3	-1.7	-0.2	0.1
Bone: elastic displacement	0.6	0.7	1.0	0.3	0.8	0.9	1.0	-1.0
Bone: elastic work	2.7	3.5	6.4	2.5	2.5	1.9	0.6	-0.8
Bone: endosteal estimation	0.1	0.1	0.4	-0.6	-0.2	0.3	0.3	-0.3
Bone: endosteal perimeter	0.5	1.0	3.0	-1.7	-0.8	0.3	0.8	-0.8
Epididymis fat weight	2.8	6.4	9.5	-2.3	-3.1	-2.8	-2.2	2.1
Delta time in closed arm before/after self-admin	0.5	0.4	0.8	0.2	0.6	0.6	0.9	-0.8
Delta time in open arm before/after self-admin	0.8	0.8	1.2	-0.6	-1.0	-0.8	-1.1	0.9
Diff in mean of infusions in LGA sessions	1.0	1.1	1.7	0.2	-0.9	-1.2	-1.3	1.3
Delay discount exponential model param	1.0	1.1	2.5	-1.6	-1.5	-0.8	-0.2	0.3
Extinction: sum of active levers before priming	1.1	1.1	2.3	-1.3	-1.5	-0.9	-0.6	0.5
Active lever presses in extinction session 6	0.7	0.7	1.5	-1.1	-1.2	-0.5	-0.5	0.5
Bone: final force	0.6	0.9	2.2	1.5	0.8	0.6	-1.0	0.6
Bone: final moment	0.5	0.7	1.7	1.3	0.8	0.7	-0.7	0.4
Food consumed during 24 hour testing period	0.2	0.2	0.5	-0.5	-0.7	-0.4	-0.3	0.3
Glucose	2.3	3.5	6.6	2.1	2.6	1.8	1.2	-1.2
Heart weight	0.2	0.2	0.6	0.0	-0.3	-0.3	-0.8	0.6
Delay discount hyperbolic model param	1.0	1.1	2.3	-1.5	-1.5	-0.8	-0.3	0.4
Intermittent access intake day 1-15 change	1.7	1.7	2.9	-1.0	0.4	1.3	1.7	-1.7
Intermittent access intake escalation	1.9	1.9	3.0	-0.2	1.1	1.5	1.7	-1.7
Intermittent access intake escalation 2	2.0	2.0	3.1	0.3	1.4	1.4	1.8	-1.7
Intermitt. access day 1 inactive lever presses	2.1	2.3	3.7	1.7	1.9	1.6	1.1	-1.1
Intermitt. access day 15 inactive lever presses	0.7	0.8	1.2	0.5	1.0	0.8	1.1	-1.0
Intermitt. access escalation Index	6.6	5.8	9.3	0.7	-1.5	-2.9	-2.9	3.1
Intermittent access day 1 total infusions	0.2	0.3	0.9	-0.9	-0.7	-0.3	-0.1	0.0
Intermittent access day 15 total infusions	1.1	1.3	2.1	-1.4	-0.2	0.9	1.3	-1.3
Intermittent access terminal intake (last 3 days)	0.8	0.8	2.8	-1.7	-1.0	-0.3	0.3	-0.3
Intermittent access total infusions	0.5	0.6	1.3	-1.1	-0.2	0.5	0.8	-0.8
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.6	0.6	0.6	-0.1	-0.1
Intermittent access day 15 total locomotion	0.7	0.8	1.2	0.1	0.8	1.1	1.0	-1.1
Intermittent access total locomotion	0.2	0.2	0.4	-0.0	0.4	0.7	0.4	-0.5
Intermittent access standard deviation	3.8	4.1	7.0	-0.9	1.0	2.2	2.6	-2.6
Left kidney weight	1.6	4.4	13.6	3.7	2.5	0.5	-1.1	0.9
Right kidney weight	1.3	3.8	11.2	3.4	2.1	0.2	-1.3	1.1
Cocaine induced anxiety	0.6	0.7	1.5	-0.6	0.2	0.7	1.2	-1.1
Post-drug Anxiety	0.1	0.2	0.4	-0.6	-0.3	-0.1	0.4	-0.3
Baseline Anxiety	0.2	0.2	0.3	0.2	-0.2	-0.5	-0.6	0.6
Tail length	3.1	9.3	16.0	1.8	-1.2	-3.3	-4.0	3.9
Length with tail	1.9	7.0	10.9	0.8	-1.4	-3.2	-3.3	3.3
Length without tail	1.2	2.5	3.8	-1.0	-1.6	-2.0	-1.7	1.6
Times rat made contact with spout	0.8	0.9	2.8	1.7	0.9	0.3	-0.7	0.5
Lifetime Intake	0.6	0.7	1.2	-1.1	-0.2	0.7	0.9	-1.0
Liver weight, left	1.7	2.6	4.4	1.2	-0.6	-1.7	-2.1	2.1
Liver weight, right	1.2	2.0	3.1	0.5	-0.9	-1.6	-1.7	1.8
Locomotor activity	0.0	0.1	0.2	-0.2	-0.1	-0.4	-0.2	0.1
Locomotor testing distance	0.0	0.0	0.1	-0.1	-0.0	-0.3	-0.0	0.0
Locomotor testing rearing	0.2	0.3	1.0	-1.0	-0.3	-0.0	0.5	-0.5
Locomotion in novel chamber	4.7	5.7	8.5	0.0	2.0	2.8	2.9	-2.9
Locomotion in novel chamber post-restriction	0.2	0.2	0.4	-0.6	-0.1	0.4	0.5	-0.6
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.3	-0.3	-0.1	-0.4	0.3
Change in fecal boli incidents, locomotor task	0.4	0.3	1.2	1.1	0.4	-0.0	-0.3	0.4
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.7	-0.4	-0.3	0.8	0.3	-0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	-0.5	-0.2	0.0	0.0
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.5	-0.4	-0.1	0.2	-0.1
Rest time, locomotor task time 1	0.3	0.3	0.7	-0.4	0.1	0.3	0.8	-0.7
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.3	-0.2	0.4	0.1	-0.2
Vertical activity count, locomotor time 1	0.3	0.3	0.9	-1.0	-0.7	0.0	-0.0	-0.1
Time >=10cm from walls, locomotor time 2	0.8	0.9	2.0	1.1	1.0	1.4	0.2	-0.5
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.6	0.4	-0.1	-0.0	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.2	-0.0	-0.3	-0.1	0.2
Rest time, locomotor task time 2	0.2	0.2	0.5	-0.6	-0.6	-0.7	0.2	0.1
Distance moved, locomotor task time 2	0.7	0.8	1.2	0.1	0.7	1.1	1.0	-1.1
Vertical activity count, locomotor time 2	0.3	0.3	0.7	0.7	0.8	0.6	0.3	-0.3
Light reinforcement 1	0.0	0.0	0.0	-0.2	0.2	-0.1	0.1	-0.2
Light reinforcement 2	1.3	1.7	4.4	2.1	1.9	0.7	0.0	-0.1
Bone: marrow area	0.1	0.1	0.3	-0.6	-0.2	0.3	0.3	-0.3
Bone: maximum diameter	0.5	0.9	1.5	-0.6	0.3	1.2	1.2	-1.2
Bone: maximum force	0.5	0.9	2.3	1.5	1.1	0.7	-0.6	0.3
Bone: maximum moment	0.4	0.7	1.7	1.3	1.0	0.9	-0.3	0.1
Mean time between licks in bursts	0.7	0.9	1.5	0.4	-0.3	-1.2	-1.2	1.2
Mean num. licks in bursts	0.2	0.3	0.6	0.6	-0.2	0.1	-0.8	0.7
Cd content in liver	0.8	0.9	1.5	-1.2	-1.1	-1.2	-0.1	0.3
Co content in liver	0.1	0.1	0.3	0.4	0.5	0.5	0.1	-0.2
Cu content in liver	0.5	0.6	1.9	1.4	0.9	0.2	-0.3	0.3
Fe content in liver	0.8	0.9	1.5	0.5	-0.4	-1.2	-1.2	1.2
K content in liver	1.2	1.2	2.2	1.3	0.2	-0.4	-1.5	1.3
Mg content in liver	0.1	0.1	0.4	0.0	0.3	0.7	0.3	-0.4
Mn content in liver	0.1	0.2	0.5	-0.7	-0.5	0.1	0.0	-0.1
Na content in liver	1.6	1.7	4.8	2.2	1.8	0.8	-0.0	-0.0
Rb content in liver	0.7	0.8	2.7	-1.6	-1.0	0.1	0.5	-0.5
Se content in liver	0.5	0.6	1.8	1.3	1.0	0.4	0.0	0.0
Sr content in liver	0.5	0.5	1.0	-1.0	-0.9	-0.6	-0.2	0.2
Zn content in liver	0.3	0.4	1.1	-1.1	-0.6	0.2	0.5	-0.5
Bone: minimum diameter	0.4	0.7	2.3	1.5	1.1	0.2	-0.2	0.3
Time in familiar zone, hab. session 1	1.2	1.2	2.6	-1.6	-0.6	0.7	1.1	-1.1
Time in novel zone, hab. session 1	1.0	1.0	2.5	1.6	0.7	-0.6	-0.9	0.9
Total zone transitions, hab. session 1	1.1	1.5	5.1	-2.3	-0.8	0.2	0.8	-1.0
Total locomotion distance, hab. session 1	0.3	0.5	1.5	-1.2	-0.7	-0.5	0.1	-0.1
Locomotion velocity, hab. session 1	0.4	0.5	1.9	-1.4	-0.7	-0.2	0.3	-0.3
Time in familiar zone, hab. session 2	1.0	1.1	3.4	-1.8	-1.2	-0.5	0.2	-0.1
Time in novel zone, hab. session 2	2.5	2.5	7.5	2.7	2.0	0.9	-0.2	0.0
Total zone transitions, hab. session 2	0.5	0.6	1.7	-1.3	-0.9	-0.6	-0.4	0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.4	0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.1	-0.2	-0.2	-0.4	-0.3	0.3
Novel to familiar place preference ratio	0.5	0.5	0.9	-0.1	0.4	0.9	0.8	-0.9
Novelty place preference	0.1	0.1	0.3	-0.0	0.2	0.5	0.4	-0.4
Time in novel zone, NPP test	0.0	0.0	0.1	-0.2	-0.1	0.3	0.2	-0.2
Total zone transitions, NPP test	0.5	0.7	2.9	-1.7	-0.7	-0.1	0.3	-0.5
Total locomotion distance, NPP test	0.3	0.4	0.9	-1.0	0.0	0.3	0.7	-0.8
Locomotion velocity, NPP test	0.6	0.8	1.4	-0.7	0.5	0.8	1.2	-1.2
Intraocular pressure	1.1	1.6	3.1	-1.0	0.3	1.0	1.8	-1.6
Delta distance traveled before/after self-admin	1.7	1.8	2.7	-0.7	-1.6	-1.4	-1.4	1.4
Delta ambulatory time before/after self-admin	1.3	1.5	2.2	-0.6	-1.5	-1.3	-1.2	1.3
Parametrial fat weight	7.3	14.3	19.6	-2.6	-4.4	-4.2	-3.7	3.7
Pavlov. Cond. lever latency	0.3	0.4	0.8	-0.9	-0.1	0.2	0.8	-0.7
Pavlov. Cond. magazine entry latency	0.7	0.9	1.4	0.0	-0.9	-0.9	-1.1	1.2
Pavlov. Cond. change in total contacts	0.3	0.3	1.1	1.0	0.7	0.4	0.1	-0.0
Pavlov. Cond. index score	0.7	0.8	1.6	0.4	-0.6	-0.8	-1.3	1.2
Pavlov. Cond. latency score	0.9	1.2	2.2	0.7	-0.6	-0.9	-1.5	1.4
Pavlov. Cond. lever contacts	0.3	0.3	0.6	0.7	0.0	-0.2	-0.8	0.7
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	0.0	0.6	0.6	0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.3	-1.1	0.1	0.5	1.0	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.1	0.2	-0.7	-0.6	-1.0	1.0
Pavlov. Cond. response bias	0.3	0.4	0.7	0.1	-0.6	-0.6	-0.8	0.8
Pavlov. Cond. lever latency	1.2	1.7	2.8	-1.0	-1.7	-1.5	-1.0	1.1
Pavlov. Cond. magazine entry latency	0.7	0.8	1.9	1.4	1.3	0.6	-0.3	0.1
Pavlov. Cond. change in total contacts	0.8	1.1	2.0	1.1	1.4	1.4	0.4	-0.6
Pavlov. Cond. index score	1.5	1.9	3.7	1.2	1.9	1.6	0.9	-1.1
Pavlov. Cond. latency score	1.8	2.3	4.2	1.3	2.1	1.7	1.1	-1.2
Pavlov. Cond. lever contacts	0.6	0.9	1.9	1.0	1.4	0.9	0.4	-0.6
Pavlov. Cond. magazine entry number	0.8	1.0	2.2	-1.4	-1.5	-0.9	-0.0	0.2
Pavlov. Cond. intertrial magazine entries	1.3	1.7	3.6	-1.9	-1.8	-1.2	-0.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.7	3.3	1.1	1.8	1.5	0.9	-1.0
Pavlov. Cond. response bias	0.8	1.1	2.5	1.3	1.6	0.9	0.4	-0.5
Time in closed arm before self-admin	2.5	2.8	3.6	-1.0	-1.8	-1.9	-1.7	1.7
Time in closed arm after self-admin	0.0	0.0	0.1	0.3	0.2	-0.2	0.0	0.1
Time in open arm before self-admin	4.3	4.6	7.6	2.3	2.8	2.2	1.7	-1.6
Time in open arm after self-admin	1.1	1.2	2.1	1.0	1.2	1.4	0.7	-0.8
Bone: periosteal estimation	0.3	0.5	0.9	0.7	0.9	0.9	0.4	-0.5
Bone: periosteal perimeter	0.4	0.6	1.1	-0.1	0.5	1.0	0.9	-0.9
Bone: post-yield work	0.3	0.5	0.7	-0.2	-0.7	-0.8	-0.8	0.8
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	-0.7	-0.5	-0.1	-0.1	-0.0
Progressive ratio test 1 breakpoint	0.4	0.4	1.1	-1.1	-0.9	-0.4	-0.3	0.2
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.6	0.5	0.9	1.3	0.9	-0.9
Progressive ratio test 2 active lever presses	0.4	0.4	0.9	-1.0	-0.2	0.5	0.6	-0.7
Progressive ratio test 2 breakpoint	0.5	0.5	1.0	-1.0	-0.2	0.6	0.7	-0.8
Progressive ratio test 2 inactive lever presses	0.8	1.0	1.6	-0.5	0.4	1.2	1.2	-1.3
Incentive Sensitization - Responses	0.2	0.2	0.3	-0.5	-0.1	0.4	0.5	-0.5
Incentive Sensitization - Breakpoint	0.1	0.2	0.2	-0.4	-0.0	0.4	0.5	-0.5
Sum of active levers in priming session hrs 5-6	1.8	1.8	2.7	-0.6	-1.6	-1.2	-1.5	1.4
Progressive ratio	0.7	0.9	1.2	-1.1	-0.0	1.0	0.9	-1.1
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.3	0.4	0.1	0.2	-0.2
Seeking ratio, punishment vs. effort	0.6	0.7	1.9	1.4	0.5	-0.7	-0.6	0.8
Retroperitoneal fat weight	0.0	0.1	0.2	0.2	0.1	-0.4	-0.2	0.2
Reaction time number correct	0.0	0.1	0.1	-0.0	-0.3	-0.2	-0.4	0.3
Reaction time mean minus median	0.3	0.4	0.9	-0.3	0.3	0.4	0.9	-0.8
Reaction time mean minus median AUC	0.6	0.8	2.4	-1.5	-0.7	-0.0	0.8	-0.7
Reaction time num false alarms	1.2	1.6	2.6	-1.2	0.3	1.2	1.6	-1.6
Reaction time num false alarms AUC	1.2	1.7	2.7	-1.1	0.3	1.3	1.6	-1.6
Reaction time trials correct on left	0.0	0.1	0.1	-0.0	-0.3	-0.2	-0.4	0.3
Reaction time trials on left	0.0	0.1	0.1	-0.1	-0.2	-0.2	-0.3	0.3
Reaction time mean	0.0	0.1	0.1	0.2	0.2	-0.1	0.4	-0.2
Reaction time mean AUC	0.2	0.3	0.6	0.2	0.5	0.3	0.8	-0.6
Median of all reaction times	0.1	0.1	0.3	0.6	0.4	-0.1	0.2	-0.0
Reaction time omissions	0.0	0.0	0.0	0.2	0.1	0.1	0.1	-0.1
Reaction time false alarm rate	1.0	1.4	2.2	-1.1	0.2	1.2	1.4	-1.5
Reaction time premature initiation rate	0.2	0.3	0.9	-0.9	-0.8	-0.2	0.0	0.0
Reaction time premature initiations	0.3	0.4	1.0	-1.0	-0.9	-0.3	-0.1	0.1
Std. dev. reaction times	0.3	0.5	0.9	-0.4	0.2	0.6	1.0	-0.9
Reaction time trials completed	0.0	0.1	0.1	-0.1	-0.2	-0.2	-0.3	0.3
Reaction time trials AUC	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.3	0.2
Run reversals in cocaine runway, females	0.8	0.8	1.4	-0.3	0.6	0.8	1.2	-1.2
Run reversals in cocaine runway, males	0.4	0.4	0.8	-0.9	-0.2	0.1	0.9	-0.7
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.5	0.4	0.1	-0.2	0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.6	0.2	-0.2	-0.5	0.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.2	-0.1	-0.0	-0.3	0.3
Std. dev. time between licks in bursts	0.1	0.2	0.7	-0.8	-0.5	-0.0	0.0	-0.1
Total sessions with >9 infusions	0.1	0.1	0.2	-0.4	-0.2	0.2	0.0	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.3	-0.3	-0.6	-0.2	-0.4	0.3
Short access day 10 total inactive lever presses	0.2	0.3	0.9	1.0	0.3	0.3	-0.3	0.3
Short access day 1 total infusions	1.5	1.6	2.5	-0.6	0.6	1.5	1.5	-1.6
Short access day 10 total infusions	0.5	0.6	1.7	-1.3	-0.5	0.3	0.6	-0.7
Short access total infusions	0.9	1.0	1.5	-1.1	0.0	0.9	1.2	-1.2
Short access day 1 locomotion	0.8	0.9	1.7	-0.1	0.7	1.3	1.0	-1.1
Short access day 10 total locomotion	0.6	0.7	1.3	0.7	0.9	1.2	0.6	-0.7
Short access total locomotion	0.8	0.9	1.8	0.0	0.7	1.4	0.9	-1.1
One hour access (0.3 mA shock)	1.0	1.2	3.4	-1.8	-0.7	0.5	0.9	-0.9
Compulsive drug intake	0.5	0.5	1.0	0.5	-0.2	-0.6	-1.0	1.0
One hour access (shock baseline)	0.8	0.9	2.1	-1.4	-0.4	0.5	1.0	-1.1
Social response proportion	3.1	3.3	5.1	-0.2	-1.8	-1.9	-2.3	2.2
Social responses	1.6	2.0	2.8	-0.8	-1.5	-1.7	-1.5	1.4
Social time	2.4	3.2	4.8	-1.5	-2.2	-2.0	-1.5	1.5
Soleus weight	3.4	10.0	13.2	-2.2	-3.6	-3.6	-3.1	3.0
Bone: stiffness	0.9	1.4	2.4	-0.4	-1.2	-1.1	-1.6	1.4
Tibialis anterior weight	4.4	15.1	37.5	-6.1	-5.4	-2.5	-1.3	1.0
Time to tail flick, vehicle, before self-admin	4.0	4.1	7.6	-2.2	-2.8	-2.0	-1.4	1.4
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.8	-1.3	-0.5	-0.0	0.7	-0.7
Time to tail flick, test, before self-admin	0.3	0.3	0.8	-0.9	-0.7	-0.4	-0.2	0.2
Time to tail flick, test, after self-admin	0.4	0.4	0.5	-0.0	-0.5	-0.7	-0.7	0.7
Delta time to tail flick, vehicle, before/after SA	1.7	1.6	2.5	0.2	1.2	1.4	1.6	-1.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	-0.1	-0.1	0.2	0.2	-0.2
Tibia length	0.9	2.5	4.1	1.9	0.2	-1.1	-2.0	1.9
Ambulatory time before self-admin	1.3	1.4	2.9	1.7	1.7	0.9	0.3	-0.4
Ambulatory time after self-admin	1.2	1.3	2.3	0.9	-0.4	-1.0	-1.5	1.5
Bone: tissue strength	1.4	1.3	3.0	1.7	1.5	1.1	0.1	-0.2
Total heroin consumption	3.0	3.5	5.6	-1.5	-2.4	-1.8	-1.9	1.8
Bone: trabecular number	2.6	4.1	8.0	-2.8	-2.7	-1.9	-0.8	0.9
Bone: trabecular spacing	0.7	0.9	1.5	1.0	1.1	1.2	0.5	-0.6
Bone: trabecular thickness	0.2	0.3	0.5	-0.7	-0.6	-0.6	-0.2	0.2
Bone: trabecular tissue density	1.4	1.9	3.6	1.8	1.9	1.2	0.9	-0.8
Water consumed over 24 hours	0.6	0.8	1.3	1.0	0.1	-0.6	-1.1	1.1
Number of responses in last shaping day	1.5	1.5	2.8	0.6	1.3	1.7	1.1	-1.2