Hub : Genes

LOC102556219

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	isoform ratio	XR_010066554.1	0.55	0.38	2.3e-03	0.16	0.11	0.13	0.13	2.1e-03	9.4e-03	5.6e-03	5.6e-03
2	Eye	gene expression	LOC102556219	0.29	0.21	7.1e-03	0.08	0.04	0.02	0.03	2.6e-02	9.5e-02	1.4e-01	1.1e-01
3	Brain	gene expression	LOC102556219	0.18	0.17	9.8e-05	0.04	0.04	0.04	0.04	1.5e-04	9.4e-05	5.1e-05	1.8e-04
4	Adipose	gene expression	LOC102556219	0.08	0.1	2.0e-05	0.03	0.03	0.03	0.02	4.7e-04	2.5e-04	5.0e-04	9.7e-04
5	RMTg	gene expression	LOC102556219	0.92	0.05	1.7e-03	-0.01	-0.01	-0	0.01	7.2e-01	9.0e-01	3.3e-01	1.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.3	0.6	0.9	0.9	-0.9	-0.8	-0.6	-0.2
Area under the delay curve	0.2	0.2	0.4	0.6	-0.4	-0.3	0.5	0.4
BMI with tail	0.4	1.3	2.6	-1.6	1.4	1.4	0.1	-0.2
BMI without tail	0.9	2.6	4.4	-1.9	2.1	2.0	1.0	0.2
Body weight	0.2	0.7	1.6	-1.0	1.3	0.9	-0.4	0.2
Weight adjusted by age	0.8	1.2	1.8	-1.4	1.3	1.3	0.9	0.0
Bone surface	1.2	2.2	3.1	-1.8	1.7	1.7	1.2	0.7
Bone volume	0.2	0.4	0.6	-0.7	0.7	0.7	0.4	0.4
Breakpoint value in progressive ratio session	0.5	0.6	1.2	1.1	-0.8	-0.9	-0.0	0.6
Number of licking bursts	0.1	0.2	0.8	0.2	0.2	0.3	0.3	0.9
Context. condit. distance diff. score	1.7	2.0	3.5	1.9	-1.8	-1.7	-0.8	-0.3
Locomotion velocity, session 1	0.3	0.3	1.1	-0.5	0.2	0.2	-0.4	-1.1
Locomotion distance, session 1	0.9	1.2	2.2	0.7	-1.0	-1.0	-1.1	-1.5
Locomotion velocity, session 2	0.2	0.2	0.8	-0.2	0.1	0.1	-0.9	-0.5
Locomotion distance, session 2	0.3	0.4	0.7	-0.6	0.5	0.4	0.5	-0.9
Locomotion velocity, session 3	0.0	0.0	0.2	0.4	-0.1	-0.2	0.2	0.0
Locomotion distance, session 3	0.5	0.6	2.1	0.1	0.2	0.2	1.4	0.8
Stereotopy head waving bouts, day 3	0.4	0.5	0.9	1.0	-0.8	-0.8	-0.4	0.1
Stereotopy head waving duration, day 3	1.5	1.8	3.4	1.0	-1.2	-1.2	-1.8	-1.1
Locomotion velocity, session 7	0.6	0.6	1.3	1.2	-0.7	-0.8	0.3	0.8
Locomotion distance, session 7	0.5	0.6	1.5	0.8	-0.7	-0.6	0.5	1.2
Stereotopy head waving bouts, day 7	0.3	0.4	0.8	-0.7	0.9	0.7	-0.0	-0.3
Stereotopy head waving duration, day 7	0.6	0.7	1.1	-1.0	1.1	0.9	0.1	-0.7
Locomotion velocity, session 8	0.2	0.2	0.4	0.6	-0.5	-0.5	0.5	-0.2
Locomotion distance, session 8	0.5	0.8	1.3	1.1	-1.1	-1.0	-0.3	-0.4
Degree of sensitization distance	0.0	0.1	0.2	-0.1	-0.0	0.1	-0.4	0.2
Degree of sensitization stereotypy	0.6	0.7	1.0	-1.0	1.0	0.9	-0.2	-0.8
Conditioned locomotion	0.2	0.3	0.9	0.1	-0.3	-0.3	-0.5	-0.9
Cocaine response after cond. corrected	0.2	0.2	0.5	-0.5	0.7	0.6	0.2	0.0
Cocaine response after cond. not corrected	0.2	0.2	0.4	-0.3	0.6	0.5	0.3	0.5
Cocaine response before conditioning	0.1	0.1	0.5	0.3	-0.1	-0.0	0.2	0.7
Saline control response	0.1	0.2	0.5	-0.0	-0.1	-0.1	-0.7	-0.6
Bone: connectivity density	1.0	1.5	2.3	-1.5	1.4	1.4	1.0	0.3
Bone: cortical apparent density	4.4	6.1	8.5	2.9	-2.9	-2.9	-2.3	-0.4
Bone: cortical area	0.3	0.4	0.8	-0.9	0.6	0.6	-0.3	-0.7
Bone: cortical porosity	0.2	0.2	0.6	-0.8	0.4	0.5	-0.2	-0.2
Bone: cortical porosity	0.3	0.4	0.9	-1.0	0.6	0.7	-0.4	-0.1
Bone: cortical thickness	0.4	0.6	1.6	0.4	-0.7	-0.7	-1.3	-0.5
Bone: cortical thickness	0.2	0.2	0.6	0.2	-0.5	-0.4	-0.7	-0.1
Bone: cortical tissue density	4.5	6.1	8.5	2.9	-2.8	-2.9	-2.3	-0.5
Condit. Reinf. active minus inactive responses	0.4	0.5	0.7	-0.7	0.7	0.6	0.5	-0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.3	-0.4	0.2	0.1	0.3	-1.1
Condit. Reinf. active responses	0.9	1.1	1.5	-1.2	1.2	1.1	0.8	-0.8
Condit. Reinf. inactive responses	0.4	0.5	0.8	-0.9	0.8	0.8	0.2	-0.7
Incentive salience index mean	0.5	0.6	1.2	-0.9	0.7	0.7	0.2	-1.1
Condit. Reinf. lever presses	0.3	0.4	1.0	-0.2	-0.0	-0.0	-0.9	-1.0
Condit. Reinf. active minus inactive responses	0.8	1.0	1.4	1.2	-1.2	-1.1	-0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.8	0.6	-0.7	-0.6	-0.6	-0.9
Condit. Reinf. active responses	0.5	0.6	1.0	1.0	-0.8	-0.8	-0.2	-0.8
Condit. Reinf. inactive responses	0.7	0.9	1.7	1.3	-1.1	-1.2	-0.1	-0.4
Condit. Reinf. lever presses	1.5	2.0	2.9	-1.7	1.6	1.6	1.4	-0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	0.6	-0.5	-0.5	0.1	-0.7
Conditioned reinforcement - actives	0.6	1.0	3.6	-0.2	-0.3	-0.3	-1.0	-1.9
Conditioned reinforcement - inactives	0.1	0.2	0.3	0.6	-0.6	-0.4	-0.2	-0.3
Conditioned locomotion	1.1	1.4	4.7	0.2	-0.3	-0.5	-1.4	-2.2
Patch foraging indifference point 0 sec	3.8	6.9	12.2	-3.5	3.2	3.2	1.3	0.0
Patch foraging indifference point AUC	0.6	0.8	1.5	-1.2	1.2	1.1	-0.3	-0.3
Delay disc. indifference point, 0s delay	1.7	1.8	2.9	1.7	-1.5	-1.6	-1.2	-0.5
Delay disc. indifference point, 16s delay	1.9	2.1	4.5	-1.2	1.4	1.4	2.1	1.0
Delay disc. indifference point, 2s delay	0.5	0.5	1.4	0.5	-0.1	-0.0	1.2	1.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.2	-0.1	-0.1	0.5	0.4
Delay disc. indifference point, 4s delay	1.0	1.1	2.1	1.5	-1.2	-1.2	-0.4	-0.4
Delay disc. indifference point, 8s delay	0.6	0.7	1.4	1.2	-1.0	-1.0	-0.5	-0.0
Indifference point function ln k	0.2	0.3	0.5	0.7	-0.7	-0.6	-0.3	-0.0
Indifference point function log k	0.2	0.3	0.5	0.7	-0.7	-0.6	-0.3	-0.0
Patch foraging total patch changes 0 sec	3.4	6.4	11.7	-3.4	3.1	3.1	1.1	-0.2
Patch foraging total patch changes 12 sec	1.1	1.4	2.0	-1.4	1.4	1.3	1.2	-0.1
Patch foraging total patch changes 18 sec	1.4	2.2	3.8	-2.0	1.8	1.7	-0.4	-0.7
Patch foraging total patch changes 24 sec	0.7	1.1	2.3	-1.5	1.3	1.3	-0.2	-0.1
Patch foraging total patch changes 6 sec	2.0	3.0	5.5	-2.3	2.1	2.1	0.0	-1.0
Patch foraging time to switch 0 sec	0.6	1.2	2.0	1.4	-1.4	-1.1	0.7	0.5
Patch foraging water rate 0 sec	0.7	1.5	2.9	-1.5	1.7	1.4	0.0	-0.4
Patch foraging water rate 12 sec	1.5	3.0	5.5	-2.1	2.4	2.2	0.6	0.2
Patch foraging water rate 18 sec	0.2	0.3	0.5	-0.7	0.7	0.5	0.3	-0.6
Patch foraging water rate 24 sec	0.1	0.2	0.4	-0.2	0.3	-0.0	-0.6	-0.6
Patch foraging water rate 6 sec	0.6	0.9	2.5	-0.2	0.2	0.0	-1.6	-1.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.0	0.2	0.2	0.6	0.1
Distance traveled before self-admin	0.5	0.7	1.2	-0.5	0.9	0.8	1.1	0.6
Distance traveled after self-admin	1.4	1.7	3.9	-0.8	1.2	1.2	2.0	1.1
Extensor digitorum longus weight	0.4	1.6	2.1	1.4	-1.4	-1.5	-1.1	-0.8
Bone: elastic displacement	0.7	0.8	1.0	0.7	-1.0	-0.9	-1.0	-0.8
Bone: elastic work	1.2	1.6	2.4	1.2	-1.5	-1.5	-1.4	-0.5
Bone: endosteal estimation	0.6	1.3	2.0	-1.4	1.4	1.4	0.9	-0.0
Bone: endosteal perimeter	1.2	2.6	3.9	-2.0	1.9	1.9	1.2	-0.3
Epididymis fat weight	0.2	0.8	2.4	0.0	-0.2	-0.4	-1.3	-1.5
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.1	0.1
Delta time in open arm before/after self-admin	1.6	1.6	2.3	-1.2	1.5	1.5	1.1	0.9
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.0	0.0	-0.0	-0.3	0.6
Delay discount exponential model param	0.2	0.2	0.4	-0.6	0.3	0.3	-0.6	-0.4
Extinction: sum of active levers before priming	1.2	1.3	3.6	1.3	-0.6	-0.7	0.5	1.9
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	0.1	0.0	0.3	0.4
Bone: final force	0.2	0.4	0.5	0.7	-0.7	-0.6	-0.4	0.7
Bone: final moment	0.0	0.1	0.2	0.0	-0.1	-0.1	-0.4	0.4
Food consumed during 24 hour testing period	0.9	1.3	3.7	0.7	-0.4	-0.3	1.4	1.9
Glucose	0.2	0.3	1.5	-0.2	0.0	-0.1	-1.2	-0.1
Heart weight	2.3	3.5	4.5	2.0	-2.0	-2.1	-2.1	-0.7
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.6	0.3	0.2	-0.7	-0.5
Intermittent access intake day 1-15 change	0.1	0.2	0.2	0.4	-0.4	-0.5	-0.1	0.4
Intermittent access intake escalation	0.3	0.5	0.7	0.9	-0.8	-0.8	-0.2	0.9
Intermittent access intake escalation 2	0.3	0.4	0.8	0.7	-0.6	-0.4	0.0	0.9
Intermitt. access day 1 inactive lever presses	0.1	0.3	1.1	-0.3	0.1	0.1	-0.3	-1.0
Intermitt. access day 15 inactive lever presses	0.9	1.8	2.9	1.4	-1.7	-1.5	-1.3	-0.2
Intermitt. access escalation Index	0.3	0.5	1.4	0.2	0.1	0.2	0.9	1.2
Intermittent access day 1 total infusions	1.0	1.6	2.2	1.1	-1.1	-1.2	-1.5	-1.4
Intermittent access day 15 total infusions	1.1	1.6	2.0	1.4	-1.3	-1.4	-1.4	-0.6
Intermittent access terminal intake (last 3 days)	0.6	0.7	1.2	0.8	-0.7	-0.8	-1.1	-0.9
Intermittent access total infusions	1.6	1.9	2.6	1.5	-1.4	-1.4	-1.6	-0.9
Intermittent access day 1 locomotion	0.4	0.5	1.5	0.3	-0.3	-0.3	-1.0	-1.2
Intermittent access day 15 total locomotion	1.0	1.8	5.6	-0.3	0.0	-0.1	-1.8	-2.4
Intermittent access total locomotion	0.4	0.4	1.3	0.5	-0.5	-0.4	-1.1	-0.5
Intermittent access standard deviation	0.7	1.5	3.1	1.1	-1.0	-1.2	-1.8	-0.9
Left kidney weight	0.0	0.1	0.2	0.5	-0.3	-0.5	-0.4	-0.0
Right kidney weight	0.1	0.7	1.1	1.0	-0.7	-0.8	-0.4	0.9
Cocaine induced anxiety	0.1	0.1	0.2	-0.1	0.3	0.2	0.5	0.4
Post-drug Anxiety	0.4	0.4	1.0	0.6	-0.4	-0.1	0.8	1.0
Baseline Anxiety	0.4	0.4	0.8	0.7	-0.6	-0.1	0.6	0.9
Tail length	0.0	0.1	0.2	0.5	-0.1	-0.3	-0.3	-0.1
Length with tail	0.0	0.2	0.4	0.1	0.2	-0.2	-0.6	-0.6
Length without tail	0.1	0.4	0.8	-0.4	0.3	-0.1	-0.9	-0.9
Times rat made contact with spout	0.2	0.2	1.2	0.2	0.0	-0.0	-0.2	1.1
Lifetime Intake	1.8	2.2	3.2	1.4	-1.4	-1.4	-1.8	-1.4
Liver weight, left	2.3	3.8	4.9	2.2	-2.1	-2.2	-2.1	-0.5
Liver weight, right	1.9	3.4	5.0	1.7	-1.9	-1.9	-2.2	-1.2
Locomotor activity	0.6	0.9	3.4	-0.4	0.2	0.0	-0.8	-1.9
Locomotor testing distance	1.0	1.8	3.2	-1.8	1.6	1.5	0.5	-0.9
Locomotor testing rearing	0.1	0.2	0.5	-0.1	0.1	-0.0	-0.7	-0.5
Locomotion in novel chamber	1.2	1.6	2.0	-1.2	1.4	1.4	1.3	0.9
Locomotion in novel chamber post-restriction	0.5	0.8	1.1	1.0	-1.1	-0.9	-1.0	0.2
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	0.3	-0.2	-0.3	-0.4	0.9
Change in fecal boli incidents, locomotor task	0.3	0.3	1.0	0.1	-0.3	-0.3	-0.3	-1.0
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	-0.6	0.8	0.6	0.1	-0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.3	0.3	0.2	-0.4	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.3	0.4	0.3	-0.1	0.2
Rest time, locomotor task time 1	0.6	0.7	1.9	-0.4	0.6	0.7	0.8	1.4
Distance moved, locomotor task time 1	0.2	0.3	0.9	0.3	-0.5	-0.3	-0.0	-0.9
Vertical activity count, locomotor time 1	0.1	0.3	1.0	-0.3	0.2	0.3	-0.5	-1.0
Time >=10cm from walls, locomotor time 2	1.3	1.9	3.0	1.7	-1.6	-1.7	-1.1	-0.3
Bouts of movement, locomotor time 2	0.4	0.7	1.3	-0.9	1.1	0.9	-0.4	-0.6
Total resting periods, locomotor time 2	0.4	0.6	1.3	-0.9	1.1	0.9	-0.1	-0.4
Rest time, locomotor task time 2	0.5	0.7	1.0	-0.7	0.6	0.8	0.9	1.0
Distance moved, locomotor task time 2	1.4	1.6	2.3	1.5	-1.5	-1.4	-1.0	-0.8
Vertical activity count, locomotor time 2	0.7	0.9	2.3	0.7	-0.8	-0.8	-1.5	-0.8
Light reinforcement 1	0.1	0.2	0.4	0.6	-0.6	-0.4	0.0	-0.2
Light reinforcement 2	0.1	0.2	0.4	0.5	-0.7	-0.5	-0.4	-0.0
Bone: marrow area	0.5	1.1	1.7	-1.3	1.3	1.2	0.8	-0.0
Bone: maximum diameter	0.5	0.9	1.6	-1.3	1.1	1.1	0.6	-0.5
Bone: maximum force	0.1	0.1	0.3	0.0	-0.1	-0.1	-0.4	0.5
Bone: maximum moment	0.1	0.2	0.5	-0.7	0.5	0.5	-0.2	0.3
Mean time between licks in bursts	2.0	4.9	7.8	2.6	-2.6	-2.8	-1.7	-0.9
Mean num. licks in bursts	0.0	0.1	0.2	-0.2	-0.0	-0.2	-0.4	-0.3
Cd content in liver	1.0	1.2	2.4	-1.5	1.1	0.9	-0.5	-1.0
Co content in liver	0.2	0.2	0.6	0.2	-0.3	-0.3	-0.4	-0.7
Cu content in liver	0.7	0.9	1.3	1.1	-1.1	-1.1	-0.6	0.6
Fe content in liver	0.0	0.1	0.1	0.1	-0.1	-0.3	-0.4	-0.2
K content in liver	1.6	1.5	2.2	1.5	-1.5	-1.4	-1.0	0.6
Mg content in liver	0.6	0.6	1.8	-0.4	0.4	0.6	0.6	1.4
Mn content in liver	0.1	0.1	0.5	-0.0	0.1	0.2	0.2	0.7
Na content in liver	2.2	2.3	3.7	1.8	-1.9	-1.9	-1.0	0.4
Rb content in liver	0.4	0.5	0.6	0.8	-0.7	-0.8	-0.8	-0.5
Se content in liver	0.1	0.1	0.2	-0.2	0.4	0.4	0.4	-0.2
Sr content in liver	1.0	0.9	1.4	-1.2	1.1	1.0	0.6	-0.5
Zn content in liver	0.5	0.5	0.9	-0.9	0.8	0.9	-0.1	-0.5
Bone: minimum diameter	1.2	2.2	4.4	-2.1	1.8	1.8	0.4	-0.4
Time in familiar zone, hab. session 1	1.6	1.6	2.3	1.5	-1.5	-1.5	-0.8	-0.8
Time in novel zone, hab. session 1	3.9	3.9	6.0	-2.4	2.4	2.4	1.1	0.8
Total zone transitions, hab. session 1	0.8	1.1	2.0	1.4	-1.4	-1.3	-0.2	0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.4	-0.3	-0.3	0.4	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.5	-0.4	-0.4	0.4	0.1
Time in familiar zone, hab. session 2	0.6	0.6	1.1	1.0	-0.6	-0.7	-0.0	1.1
Time in novel zone, hab. session 2	0.8	0.8	1.6	-1.3	0.8	0.8	-0.1	-1.0
Total zone transitions, hab. session 2	3.5	4.5	6.7	2.6	-2.5	-2.6	-1.6	-0.4
Total locomotion distance, hab. session 2	2.1	2.7	3.8	1.9	-1.9	-1.9	-1.6	-0.4
Locomotion velocity, hab. session 2	1.5	2.0	3.2	1.8	-1.7	-1.7	-1.1	-0.4
Novel to familiar place preference ratio	0.4	0.5	0.8	-0.9	0.9	0.8	-0.5	0.2
Novelty place preference	0.3	0.4	0.7	-0.7	0.6	0.5	-0.8	0.0
Time in novel zone, NPP test	0.4	0.5	0.7	-0.8	0.7	0.7	-0.8	0.1
Total zone transitions, NPP test	1.3	1.8	3.1	1.5	-1.8	-1.7	-0.9	-0.1
Total locomotion distance, NPP test	0.3	0.4	0.6	0.7	-0.8	-0.7	-0.8	0.0
Locomotion velocity, NPP test	0.3	0.4	0.6	0.7	-0.8	-0.7	-0.5	-0.0
Intraocular pressure	0.0	0.0	0.0	0.1	0.0	-0.1	-0.1	0.0
Delta distance traveled before/after self-admin	0.3	0.3	0.5	-0.6	0.6	0.7	0.6	-0.4
Delta ambulatory time before/after self-admin	0.2	0.3	0.4	-0.5	0.5	0.6	0.7	-0.3
Parametrial fat weight	4.3	10.0	15.8	-3.8	4.0	3.8	2.0	1.2
Pavlov. Cond. lever latency	0.4	0.5	0.9	0.9	-0.7	-0.8	-0.4	0.6
Pavlov. Cond. magazine entry latency	0.5	0.6	1.8	0.2	-0.5	-0.5	-0.8	-1.3
Pavlov. Cond. change in total contacts	0.6	0.6	1.1	-1.1	0.8	0.8	0.2	-0.8
Pavlov. Cond. index score	0.4	0.5	2.1	-0.5	0.2	0.2	-0.5	-1.5
Pavlov. Cond. latency score	0.4	0.5	2.0	-0.6	0.3	0.3	-0.5	-1.4
Pavlov. Cond. lever contacts	0.3	0.3	0.8	-0.6	0.4	0.4	0.2	-0.9
Pavlov. Cond. magazine entry number	1.1	1.4	3.9	-0.4	0.8	0.9	1.3	2.0
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	0.7	-0.6	-0.6	-0.3	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.8	-0.6	0.4	0.3	-0.3	-1.3
Pavlov. Cond. response bias	0.5	0.6	2.4	-0.2	-0.1	-0.2	-0.6	-1.5
Pavlov. Cond. lever latency	1.0	1.4	2.6	1.6	-1.3	-1.3	-0.5	0.8
Pavlov. Cond. magazine entry latency	1.5	1.8	2.6	-1.6	1.3	1.4	1.5	0.3
Pavlov. Cond. change in total contacts	1.1	1.7	2.7	-1.6	1.5	1.5	1.1	-0.5
Pavlov. Cond. index score	1.1	1.5	2.5	-1.6	1.3	1.3	1.1	-0.6
Pavlov. Cond. latency score	0.9	1.2	2.1	-1.5	1.1	1.2	0.9	-0.5
Pavlov. Cond. lever contacts	1.2	1.6	2.8	-1.7	1.5	1.4	0.8	-0.6
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	1.0	-0.7	-0.8	-1.1	0.2
Pavlov. Cond. intertrial magazine entries	1.2	1.8	2.1	1.5	-1.3	-1.4	-1.4	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.5	2.5	-1.6	1.3	1.4	1.1	-0.5
Pavlov. Cond. response bias	1.1	1.4	2.5	-1.6	1.3	1.3	0.9	-0.6
Time in closed arm before self-admin	0.1	0.1	0.2	0.4	-0.3	-0.2	0.4	0.4
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3	-0.2
Time in open arm before self-admin	0.4	0.5	1.2	-0.7	0.3	0.2	-0.7	-1.1
Time in open arm after self-admin	2.2	2.4	3.8	-1.7	1.9	1.9	0.9	0.9
Bone: periosteal estimation	0.5	1.1	2.1	-1.4	1.2	1.2	0.4	-0.4
Bone: periosteal perimeter	0.5	0.9	1.6	-1.3	1.1	1.1	0.3	-0.6
Bone: post-yield work	0.9	1.3	2.0	-1.4	1.4	1.3	0.7	0.5
Progressive ratio test 1 active lever presses	3.6	4.5	5.7	1.9	-2.0	-2.1	-2.4	-2.2
Progressive ratio test 1 breakpoint	4.2	5.2	6.9	2.1	-2.1	-2.3	-2.6	-2.2
Progressive ratio test 1 inactive lever presses	2.8	4.1	4.9	1.9	-1.9	-2.1	-2.2	-1.9
Progressive ratio test 2 active lever presses	0.8	1.0	2.7	0.5	-0.6	-0.6	-1.1	-1.7
Progressive ratio test 2 breakpoint	1.1	1.3	3.1	0.7	-0.7	-0.8	-1.3	-1.8
Progressive ratio test 2 inactive lever presses	0.5	0.8	2.5	0.4	-0.6	-0.6	-0.9	-1.6
Incentive Sensitization - Responses	0.2	0.2	0.9	-0.3	0.2	0.3	-0.2	-0.9
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.4	0.4	0.5	0.1	-0.7
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.9	0.8	-0.6	-0.6	0.1	1.0
Progressive ratio	0.2	0.3	0.4	0.5	-0.6	-0.6	-0.6	0.5
Food seeking constrained by brief footshock	4.7	5.8	8.7	2.4	-2.5	-2.6	-3.0	-1.2
Seeking ratio, punishment vs. effort	1.0	1.5	2.4	1.1	-1.1	-1.2	-1.5	-1.2
Retroperitoneal fat weight	0.3	1.3	2.4	-1.4	1.5	1.2	-0.5	-0.6
Reaction time number correct	0.1	0.2	0.3	-0.4	0.6	0.1	-0.3	-0.5
Reaction time mean minus median	0.2	0.5	1.0	-1.0	0.9	0.7	0.3	-0.1
Reaction time mean minus median AUC	0.0	0.1	0.4	-0.6	0.3	0.3	0.1	0.0
Reaction time num false alarms	0.2	0.3	0.6	-0.8	0.5	0.5	0.3	-0.4
Reaction time num false alarms AUC	0.5	0.8	1.7	-1.3	1.0	0.9	0.6	-0.5
Reaction time trials correct on left	0.1	0.2	0.3	-0.4	0.6	0.1	-0.3	-0.5
Reaction time trials on left	0.1	0.2	0.4	-0.5	0.6	0.2	-0.3	-0.5
Reaction time mean	0.5	0.8	1.3	-1.0	0.9	0.9	1.1	0.3
Reaction time mean AUC	0.2	0.4	0.7	-0.7	0.6	0.5	0.8	0.3
Median of all reaction times	0.7	0.9	1.9	-1.0	0.9	0.9	1.4	0.5
Reaction time omissions	0.4	0.6	1.3	-1.1	0.9	0.8	0.3	0.1
Reaction time false alarm rate	0.6	0.9	1.5	-1.2	0.9	1.0	1.0	-0.1
Reaction time premature initiation rate	0.3	0.4	0.7	0.7	-0.3	-0.4	0.7	0.9
Reaction time premature initiations	0.1	0.3	0.5	0.7	-0.2	-0.6	0.4	0.5
Std. dev. reaction times	1.0	1.9	3.2	-1.8	1.7	1.5	1.2	0.3
Reaction time trials completed	0.1	0.2	0.4	-0.5	0.6	0.2	-0.3	-0.5
Reaction time trials AUC	0.1	0.2	0.4	-0.5	0.6	0.2	-0.4	-0.5
Run reversals in cocaine runway, females	0.1	0.1	0.4	0.1	-0.2	-0.3	-0.4	-0.7
Run reversals in cocaine runway, males	0.6	0.6	0.9	-1.0	1.0	1.0	0.5	-0.3
Latency to leave start box in cocaine runway	0.3	0.4	0.7	0.4	-0.6	-0.7	-0.8	0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.5	0.2	0.1	-0.5	0.4
Latency to leave start box in cocaine runway, M	0.6	0.5	0.8	0.9	-0.9	-0.8	-0.0	0.6
Std. dev. time between licks in bursts	0.1	0.2	0.7	0.3	0.2	-0.0	0.2	0.8
Total sessions with >9 infusions	2.1	2.6	4.2	1.2	-1.3	-1.5	-1.8	-2.0
Short access day 1 total inactive lever presses	0.5	0.6	1.4	0.8	-0.8	-0.6	-1.2	-0.0
Short access day 10 total inactive lever presses	0.8	2.1	3.4	-1.2	1.3	1.5	1.3	1.8
Short access day 1 total infusions	0.5	0.7	1.1	0.7	-0.6	-0.7	-1.0	-1.0
Short access day 10 total infusions	1.6	2.0	2.7	1.4	-1.4	-1.5	-1.6	-1.1
Short access total infusions	1.2	1.6	2.8	1.0	-1.0	-1.1	-1.4	-1.7
Short access day 1 locomotion	1.6	1.9	5.5	-0.2	-0.2	-0.5	-2.0	-2.3
Short access day 10 total locomotion	0.0	0.1	0.1	-0.1	0.2	0.2	-0.3	-0.3
Short access total locomotion	0.8	1.0	1.8	0.7	-0.7	-0.7	-1.3	-1.4
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.3	-0.1	-0.1	0.1	-0.0
Compulsive drug intake	3.2	3.8	5.4	-2.1	2.1	2.0	2.3	0.8
One hour access (shock baseline)	1.4	2.1	3.1	1.7	-1.6	-1.6	-1.4	-0.6
Social response proportion	0.1	0.1	0.2	-0.5	0.5	0.5	-0.0	0.3
Social responses	1.2	1.6	3.3	0.8	-1.0	-1.0	-1.8	-1.3
Social time	0.8	1.1	4.2	0.1	-0.4	-0.4	-1.1	-2.0
Soleus weight	0.0	0.1	0.1	0.4	-0.4	-0.3	0.1	-0.2
Bone: stiffness	0.1	0.2	0.7	0.2	-0.0	-0.0	-0.0	0.9
Tibialis anterior weight	6.1	20.6	28.8	-5.3	5.4	5.4	3.9	1.4
Time to tail flick, vehicle, before self-admin	1.2	1.2	1.8	-1.4	1.3	1.3	0.9	-0.3
Time to tail flick, vehicle, after self-admin	0.7	0.9	1.7	-1.0	1.3	1.3	0.4	0.5
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.2	-0.1	0.1	0.6	0.1
Time to tail flick, test, after self-admin	0.5	0.5	1.6	0.4	-0.3	-0.4	-0.6	-1.3
Delta time to tail flick, vehicle, before/after SA	0.5	0.4	1.2	0.7	-0.5	-0.4	0.0	1.1
Delta time to tail flick, test, before/after SA	0.2	0.3	0.6	-0.6	0.7	0.5	-0.2	-0.4
Tibia length	1.8	4.9	7.9	2.7	-2.5	-2.8	-1.7	0.1
Ambulatory time before self-admin	0.1	0.2	0.5	-0.2	0.5	0.3	0.7	0.3
Ambulatory time after self-admin	1.2	1.4	3.6	-0.9	1.1	1.1	1.9	0.4
Bone: tissue strength	0.3	0.3	1.1	-0.3	0.4	0.4	0.4	1.1
Total heroin consumption	0.7	0.9	1.6	1.3	-1.0	-1.0	-0.5	0.7
Bone: trabecular number	0.2	0.3	0.4	0.4	-0.6	-0.5	-0.6	-0.5
Bone: trabecular spacing	0.2	0.3	1.3	0.2	-0.0	0.1	0.6	1.1
Bone: trabecular thickness	0.3	0.3	0.8	0.5	-0.6	-0.5	-0.9	-0.3
Bone: trabecular tissue density	10.0	14.8	21.8	4.7	-4.5	-4.6	-3.3	-0.3
Water consumed over 24 hours	0.3	0.4	1.1	0.2	-0.1	0.2	0.8	1.0
Number of responses in last shaping day	0.6	0.6	2.1	0.0	0.2	-0.2	-1.0	-1.4