Hub : Genes

Fth1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Fth1 0.15 0.08 8.6e-08 0.16 0.14 0.14 0.16 2.4e-07 7.8e-07 1.3e-06 2.5e-07
2 Brain gene expression Fth1 0.32 0.13 0.0e+00 0.38 0.37 0.37 0.37 1.3e-37 1.5e-35 1.7e-35 1.8e-36
3 PL gene expression Fth1 0.23 0.09 0.0e+00 0.34 0.36 0.36 0.36 1.4e-38 1.1e-41 9.2e-42 1.5e-41
4 NAcc gene expression Fth1 0.13 0.06 0.0e+00 0.16 0.2 0.18 0.18 3.2e-18 4.4e-22 6.0e-20 2.0e-20
5 IL gene expression Fth1 0.54 0.16 9.2e-13 0.35 0.35 0.39 0.38 2.4e-09 2.4e-09 2.5e-10 4.9e-10
6 Liver mRNA stability Fth1 0.1 0.05 1.6e-11 0.08 0.08 0.06 0.07 4.6e-09 2.8e-09 3.2e-07 9.4e-09
7 OFC gene expression Fth1 0.36 0.16 3.8e-06 0.12 0.14 0.09 0.11 7.4e-04 3.1e-04 3.1e-03 1.4e-03
8 Brain mRNA stability Fth1 0.11 0.07 1.6e-07 0.07 0.07 0.06 0.07 1.8e-07 1.8e-07 1.4e-06 4.7e-07
9 BLA gene expression Fth1 0.3 0.15 8.1e-12 0.2 0.19 0.17 0.18 5.3e-11 1.8e-10 1.7e-09 7.7e-10
10 LHb gene expression Fth1 0.18 0.12 2.0e-03 0.05 0.03 0.02 0.03 2.7e-02 8.1e-02 9.9e-02 8.6e-02
11 Liver gene expression Fth1 0.1 0.06 3.6e-10 0.05 0.07 0.07 0.07 1.7e-06 1.9e-08 6.0e-08 2.0e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.10.20.4-0.5-0.5-0.30.3-0.4-0.50.5-0.3-0.30.10.6
Area under the delay curve0.10.10.3-0.1-0.2-0.20.1-0.3-0.30.4-0.4-0.50.40.6
BMI with tail2.78.611.9-2.5-2.7-2.52.9-2.7-3.23.3-3.0-2.9-3.03.5
BMI without tail1.42.93.7-1.4-1.5-1.51.8-1.7-1.71.8-1.9-1.8-1.71.8
Body weight3.916.319.5-3.8-4.0-3.84.0-4.0-4.24.3-4.4-4.2-3.14.4
Weight adjusted by age2.32.67.0-1.5-1.6-1.41.7-1.3-1.61.5-1.3-1.2-2.71.4
Bone surface1.22.13.0-1.7-1.7-1.41.3-1.5-1.71.6-1.3-1.3-0.51.7
Bone volume0.40.61.1-1.0-1.0-0.70.6-0.7-1.00.9-0.5-0.5-0.01.0
Breakpoint value in progressive ratio session2.22.43.2-1.6-1.8-1.71.6-1.5-1.51.3-1.5-1.4-1.71.2
Number of licking bursts0.00.00.00.10.0-0.0-0.10.00.0-0.0-0.1-0.00.00.1
Context. condit. distance diff. score0.10.10.30.50.40.5-0.20.40.3-0.20.30.3-0.0-0.2
Locomotion velocity, session 10.10.10.4-0.1-0.2-0.20.4-0.2-0.20.2-0.2-0.2-0.60.1
Locomotion distance, session 10.91.22.0-0.9-1.0-1.01.2-1.0-1.11.1-1.1-1.1-1.41.1
Locomotion velocity, session 23.43.94.1-2.0-2.0-1.92.0-2.0-2.02.0-2.0-2.0-2.02.0
Locomotion distance, session 20.60.81.7-0.6-0.6-0.81.0-0.8-0.80.9-1.0-1.0-1.30.8
Locomotion velocity, session 30.50.51.2-0.5-0.6-0.40.6-0.6-0.80.9-0.7-0.7-0.71.1
Locomotion distance, session 30.00.00.4-0.1-0.10.0-0.0-0.1-0.10.1-0.1-0.10.60.2
Stereotopy head waving bouts, day 30.10.10.30.10.1-0.10.2-0.2-0.30.4-0.4-0.4-0.30.6
Stereotopy head waving duration, day 30.10.10.20.20.2-0.00.2-0.1-0.20.3-0.4-0.4-0.30.4
Locomotion velocity, session 70.00.00.10.10.00.0-0.1-0.0-0.10.1-0.1-0.10.30.3
Locomotion distance, session 70.00.00.20.30.30.2-0.20.10.1-0.0-0.1-0.10.40.1
Stereotopy head waving bouts, day 70.20.30.4-0.5-0.6-0.50.5-0.5-0.60.6-0.4-0.4-0.60.6
Stereotopy head waving duration, day 72.12.52.9-1.6-1.7-1.61.5-1.6-1.71.6-1.6-1.6-1.21.6
Locomotion velocity, session 80.00.00.1-0.0-0.1-0.20.1-0.20.00.1-0.4-0.40.30.1
Locomotion distance, session 80.00.00.20.40.30.3-0.10.20.1-0.00.00.0-0.30.0
Degree of sensitization distance0.10.10.70.30.20.00.10.0-0.20.2-0.1-0.1-0.80.3
Degree of sensitization stereotypy1.01.11.6-1.2-1.3-1.01.1-1.0-1.21.1-0.9-0.9-1.11.0
Conditioned locomotion0.70.91.3-0.8-0.9-1.00.9-0.9-0.90.9-1.1-1.0-0.80.9
Cocaine response after cond. corrected0.30.30.60.80.80.6-0.40.60.6-0.50.50.4-0.2-0.6
Cocaine response after cond. not corrected0.30.40.60.60.70.6-0.50.70.6-0.60.80.7-0.2-0.6
Cocaine response before conditioning0.10.10.5-0.7-0.6-0.20.1-0.1-0.40.20.40.3-0.10.1
Saline control response2.33.13.7-1.9-1.9-1.81.8-1.8-1.71.7-1.8-1.7-1.41.6
Bone: connectivity density1.32.12.7-1.5-1.5-1.41.4-1.5-1.61.6-1.4-1.4-0.91.6
Bone: cortical apparent density0.40.50.7-0.9-0.8-0.80.8-0.8-0.70.6-0.7-0.7-0.70.6
Bone: cortical area0.60.91.6-1.3-1.2-1.00.8-1.0-1.01.0-0.7-0.7-0.41.0
Bone: cortical porosity0.00.00.00.00.0-0.10.1-0.00.1-0.1-0.1-0.1-0.0-0.2
Bone: cortical porosity0.10.10.2-0.2-0.3-0.40.4-0.4-0.20.2-0.5-0.5-0.30.2
Bone: cortical thickness2.74.45.8-2.4-2.4-2.32.2-2.3-2.01.9-2.2-2.1-1.41.8
Bone: cortical thickness0.30.40.6-0.8-0.7-0.70.6-0.7-0.50.5-0.7-0.7-0.20.4
Bone: cortical tissue density0.50.70.9-1.0-0.9-0.90.9-0.9-0.80.7-0.8-0.8-0.80.7
Condit. Reinf. active minus inactive responses1.11.22.6-1.2-1.1-1.11.2-1.0-1.11.0-0.8-0.8-1.60.9
Condit. Reinf. active-inactive response ratio0.50.52.1-0.7-0.7-0.80.8-0.6-0.60.5-0.5-0.5-1.40.3
Condit. Reinf. active responses1.01.22.8-1.2-1.1-1.01.1-0.9-1.11.1-0.7-0.7-1.71.0
Condit. Reinf. inactive responses0.00.00.10.00.10.3-0.10.2-0.10.10.30.3-0.30.1
Incentive salience index mean1.11.31.7-1.3-1.2-1.11.2-1.1-1.21.2-0.9-0.9-1.31.1
Condit. Reinf. lever presses0.40.61.0-1.0-0.9-0.60.6-0.7-0.90.9-0.5-0.5-0.21.0
Condit. Reinf. active minus inactive responses0.40.40.90.50.50.6-0.60.70.5-0.71.00.9-0.3-0.8
Condit. Reinf. active-inactive response ratio0.40.40.80.60.60.7-0.60.80.4-0.50.90.9-0.6-0.5
Condit. Reinf. active responses0.00.10.2-0.10.00.2-0.10.20.1-0.20.50.4-0.3-0.2
Condit. Reinf. inactive responses0.00.10.5-0.3-0.1-0.00.0-0.10.0-0.00.20.00.7-0.1
Condit. Reinf. lever presses0.60.81.4-1.1-1.1-0.80.9-0.8-1.00.9-0.5-0.5-1.20.9
Condit. Reinf. lever reinforcers received0.10.10.6-0.4-0.3-0.20.3-0.1-0.30.10.20.1-0.80.0
Conditioned reinforcement - actives2.12.13.21.31.41.6-1.41.51.4-1.51.81.50.9-1.6
Conditioned reinforcement - inactives0.80.81.40.90.81.2-0.91.10.7-0.81.11.20.4-0.8
Conditioned locomotion1.51.82.61.51.31.6-1.31.41.2-1.11.41.41.1-1.1
Patch foraging indifference point 0 sec0.61.01.4-0.9-1.0-1.10.9-1.1-1.01.0-1.0-1.2-0.61.0
Patch foraging indifference point AUC1.82.12.7-1.7-1.6-1.61.4-1.5-1.51.4-1.2-1.3-1.21.3
Delay disc. indifference point, 0s delay0.10.10.20.50.20.3-0.10.1-0.00.2-0.2-0.20.30.3
Delay disc. indifference point, 16s delay0.10.10.2-0.3-0.4-0.20.2-0.2-0.40.4-0.2-0.2-0.20.4
Delay disc. indifference point, 2s delay0.10.10.60.40.30.5-0.50.30.1-0.10.30.40.80.1
Delay disc. indifference point, 24s delay0.10.10.3-0.2-0.1-0.40.2-0.4-0.30.4-0.5-0.50.30.4
Delay disc. indifference point, 4s delay0.60.61.2-0.5-0.5-0.60.6-0.8-0.70.9-1.1-1.00.31.1
Delay disc. indifference point, 8s delay0.20.20.90.60.50.3-0.40.30.4-0.2-0.0-0.10.9-0.1
Indifference point function ln k3.14.36.02.42.32.5-2.12.22.1-1.91.92.01.6-1.8
Indifference point function log k3.14.36.02.42.32.5-2.12.22.1-1.91.92.01.6-1.8
Patch foraging total patch changes 0 sec0.61.01.5-0.9-1.0-1.10.9-1.1-0.90.9-1.1-1.2-0.50.9
Patch foraging total patch changes 12 sec7.19.110.7-3.1-3.2-3.33.0-3.2-2.92.9-3.1-3.2-2.52.8
Patch foraging total patch changes 18 sec0.50.71.0-0.9-0.9-1.00.8-0.9-0.80.7-0.8-0.9-0.50.7
Patch foraging total patch changes 24 sec7.89.510.9-3.0-3.0-3.13.1-3.2-3.13.2-3.1-3.3-2.53.2
Patch foraging total patch changes 6 sec1.11.72.2-1.3-1.3-1.41.2-1.4-1.31.3-1.4-1.5-0.61.4
Patch foraging time to switch 0 sec0.40.60.9-0.9-0.7-0.70.7-0.8-0.90.9-0.5-0.7-0.81.0
Patch foraging water rate 0 sec0.60.91.40.90.70.9-0.90.91.0-1.00.81.01.2-1.1
Patch foraging water rate 12 sec1.72.53.41.91.71.8-1.51.61.6-1.61.31.51.4-1.5
Patch foraging water rate 18 sec0.60.81.71.01.01.1-0.80.80.9-0.80.60.71.3-0.7
Patch foraging water rate 24 sec1.31.82.11.31.41.4-1.31.31.5-1.41.21.41.3-1.4
Patch foraging water rate 6 sec1.01.52.21.31.21.3-1.21.21.3-1.20.91.11.5-1.2
Seeking ratio, delayed vs. immediate footshock0.00.00.10.00.10.00.0-0.1-0.10.2-0.0-0.2-0.10.2
Distance traveled before self-admin1.92.02.8-1.6-1.7-1.51.4-1.3-1.51.4-1.2-1.1-1.51.3
Distance traveled after self-admin0.10.10.3-0.4-0.6-0.40.4-0.3-0.50.4-0.2-0.2-0.50.3
Extensor digitorum longus weight6.626.027.1-5.1-5.1-4.95.1-5.1-5.25.2-5.1-5.1-4.95.2
Bone: elastic displacement0.50.61.00.90.80.6-0.60.70.9-0.90.60.60.7-1.0
Bone: elastic work0.70.91.3-0.9-0.9-1.01.0-1.0-0.80.8-1.1-1.1-0.60.7
Bone: endosteal estimation1.12.33.31.61.61.8-1.71.61.3-1.21.71.71.5-1.0
Bone: endosteal perimeter1.83.74.91.91.92.2-2.22.11.6-1.62.22.21.7-1.3
Epididymis fat weight0.30.81.41.00.91.2-1.00.90.7-0.60.70.91.1-0.4
Delta time in closed arm before/after self-admin2.62.54.3-1.0-1.3-1.51.7-1.5-1.41.6-2.1-1.9-1.41.6
Delta time in open arm before/after self-admin1.41.42.2-1.5-1.4-1.31.1-1.1-1.21.0-0.8-0.9-1.50.9
Diff in mean of infusions in LGA sessions1.82.02.4-1.5-1.5-1.51.5-1.5-1.31.2-1.4-1.5-1.41.1
Delay discount exponential model param0.10.10.30.10.20.2-0.10.30.3-0.40.40.5-0.4-0.6
Extinction: sum of active levers before priming3.63.64.4-2.0-2.1-1.91.9-1.9-1.91.8-1.8-1.8-1.81.8
Active lever presses in extinction session 62.12.03.3-1.8-1.8-1.51.4-1.4-1.41.2-1.2-1.1-1.41.1
Bone: final force1.62.73.6-1.9-1.8-1.61.6-1.7-1.71.7-1.5-1.5-1.21.7
Bone: final moment1.52.53.4-1.9-1.8-1.61.6-1.6-1.71.6-1.4-1.4-1.11.6
Food consumed during 24 hour testing period0.30.30.50.40.30.5-0.60.60.6-0.60.70.70.7-0.7
Glucose2.84.35.52.42.32.1-2.22.22.0-1.92.02.01.9-1.8
Heart weight0.60.81.81.21.30.9-0.90.80.9-0.70.70.41.0-0.6
Delay discount hyperbolic model param0.10.10.40.10.20.2-0.10.30.3-0.50.50.5-0.4-0.6
Intermittent access intake day 1-15 change1.41.41.91.10.91.1-1.11.21.2-1.31.41.31.0-1.4
Intermittent access intake escalation0.90.81.30.80.60.8-0.81.00.9-1.01.11.10.6-1.1
Intermittent access intake escalation 20.00.00.1-0.1-0.10.0-0.10.20.1-0.30.30.40.0-0.4
Intermitt. access day 1 inactive lever presses1.21.32.11.31.11.4-1.11.40.9-0.91.11.50.6-0.8
Intermitt. access day 15 inactive lever presses0.10.10.5-0.2-0.40.00.2-0.1-0.60.6-0.10.1-0.40.7
Intermitt. access escalation Index0.20.20.50.60.60.5-0.40.30.3-0.20.20.10.7-0.0
Intermittent access day 1 total infusions0.30.31.10.70.71.0-0.60.70.2-0.10.70.60.20.1
Intermittent access day 15 total infusions2.73.14.31.71.72.1-1.81.91.5-1.52.02.01.4-1.5
Intermittent access terminal intake (last 3 days)0.40.40.90.50.50.9-0.70.70.4-0.41.00.90.2-0.3
Intermittent access total infusions0.50.61.10.70.71.0-0.80.90.5-0.51.00.90.4-0.4
Intermittent access day 1 locomotion0.10.10.50.10.10.30.0-0.0-0.40.5-0.1-0.1-0.20.7
Intermittent access day 15 total locomotion0.10.10.40.2-0.20.3-0.00.2-0.30.20.10.3-0.60.3
Intermittent access total locomotion0.10.10.50.0-0.10.4-0.00.1-0.50.50.20.2-0.50.7
Intermittent access standard deviation1.11.22.01.00.91.1-0.91.21.1-1.31.21.30.1-1.4
Left kidney weight0.10.20.5-0.1-0.2-0.20.1-0.3-0.40.5-0.5-0.40.50.7
Right kidney weight0.10.30.7-0.4-0.4-0.40.4-0.5-0.60.7-0.5-0.4-0.10.8
Cocaine induced anxiety0.30.30.7-0.6-0.6-0.60.6-0.5-0.60.5-0.4-0.4-0.80.4
Post-drug Anxiety0.60.71.3-0.9-0.9-0.80.9-0.7-0.80.8-0.6-0.6-1.10.7
Baseline Anxiety1.01.11.2-1.0-1.0-1.01.1-1.1-1.01.1-1.1-1.1-1.01.0
Tail length0.92.74.2-1.6-1.7-1.71.7-1.8-1.41.5-2.1-1.9-0.81.4
Length with tail2.28.09.8-2.8-2.9-2.82.8-3.0-2.92.9-3.1-3.0-1.63.0
Length without tail1.63.64.6-2.0-1.9-1.91.8-2.0-2.02.1-1.9-1.9-1.02.2
Times rat made contact with spout0.10.10.2-0.4-0.4-0.40.4-0.4-0.20.2-0.5-0.4-0.30.1
Lifetime Intake0.40.51.10.70.81.0-0.70.80.5-0.50.80.80.3-0.3
Liver weight, left0.50.81.90.90.70.8-1.00.90.9-0.90.60.81.4-0.9
Liver weight, right0.00.00.10.20.10.2-0.20.20.1-0.10.10.20.3-0.1
Locomotor activity0.60.91.81.21.00.7-0.90.91.1-1.00.40.61.3-1.0
Locomotor testing distance0.50.81.51.21.10.7-0.90.81.1-0.90.40.61.1-0.9
Locomotor testing rearing0.81.31.61.21.31.0-1.11.11.2-1.21.11.00.9-1.2
Locomotion in novel chamber2.12.63.71.51.51.7-1.71.71.4-1.51.91.91.4-1.4
Locomotion in novel chamber post-restriction1.92.32.81.71.61.4-1.51.51.7-1.61.41.41.1-1.6
Fecal boli incidents, locomotor time 10.30.41.00.30.40.6-0.50.70.4-0.61.00.9-0.3-0.7
Change in fecal boli incidents, locomotor task0.50.51.80.90.90.8-0.70.60.7-0.40.10.41.3-0.3
Time >=10cm from walls, locomotor time 12.12.13.21.41.31.7-1.51.71.3-1.41.71.80.6-1.3
Bouts of movement, locomotor time 10.30.31.0-0.6-0.6-0.70.6-0.4-0.30.1-0.3-0.3-1.0-0.1
Total resting periods, locomotor time 10.20.20.7-0.6-0.7-0.60.5-0.4-0.30.2-0.3-0.2-0.80.0
Rest time, locomotor task time 11.31.41.91.40.91.1-1.31.31.3-1.30.81.30.9-1.3
Distance moved, locomotor task time 10.20.30.4-0.6-0.3-0.30.6-0.5-0.60.6-0.2-0.5-0.50.6
Vertical activity count, locomotor time 10.80.81.20.81.10.9-0.80.80.8-0.81.00.81.0-0.8
Time >=10cm from walls, locomotor time 20.40.41.20.20.60.5-0.60.50.5-0.61.10.80.4-0.7
Bouts of movement, locomotor time 22.02.16.7-1.3-1.6-1.41.5-1.2-1.21.1-1.4-1.2-2.60.9
Total resting periods, locomotor time 21.31.35.9-0.9-1.2-1.01.2-0.8-0.90.8-1.1-0.8-2.40.6
Rest time, locomotor task time 22.63.04.52.11.71.9-1.71.91.8-1.81.41.80.7-1.8
Distance moved, locomotor task time 20.30.30.7-0.9-0.6-0.80.5-0.7-0.60.5-0.3-0.70.10.5
Vertical activity count, locomotor time 20.10.20.90.10.4-0.1-0.20.00.4-0.40.2-0.00.9-0.4
Light reinforcement 10.20.30.60.30.40.4-0.50.40.5-0.50.80.60.7-0.6
Light reinforcement 20.30.40.90.30.40.7-0.80.60.4-0.51.00.90.9-0.4
Bone: marrow area1.22.73.71.71.71.9-1.81.81.4-1.31.81.81.6-1.1
Bone: maximum diameter0.10.20.4-0.6-0.5-0.30.2-0.3-0.50.5-0.1-0.1-0.10.6
Bone: maximum force2.13.74.8-2.2-2.1-1.81.8-1.9-2.22.1-1.7-1.7-1.32.2
Bone: maximum moment2.03.44.4-2.1-2.1-1.71.7-1.8-2.12.0-1.6-1.6-1.22.1
Mean time between licks in bursts0.71.01.8-0.7-0.8-0.81.1-0.9-0.80.9-1.3-1.1-1.30.8
Mean num. licks in bursts0.00.00.20.10.10.10.00.10.2-0.20.10.1-0.0-0.4
Cd content in liver1.11.21.51.01.01.0-1.11.11.1-1.11.21.21.1-1.2
Co content in liver2.12.43.51.51.51.4-1.41.51.7-1.81.51.51.3-1.9
Cu content in liver0.20.30.7-0.4-0.3-0.40.6-0.6-0.50.6-0.7-0.8-0.20.6
Fe content in liver0.00.00.1-0.10.00.00.1-0.1-0.10.10.0-0.1-0.30.1
K content in liver0.90.91.5-1.0-0.9-0.80.8-0.9-1.11.1-0.8-0.9-0.61.2
Mg content in liver0.30.30.7-0.5-0.5-0.40.5-0.5-0.70.8-0.4-0.5-0.40.8
Mn content in liver1.71.92.3-1.5-1.4-1.41.3-1.5-1.51.4-1.4-1.4-1.01.5
Na content in liver0.40.50.8-0.9-0.9-0.70.7-0.6-0.80.7-0.5-0.4-0.50.6
Rb content in liver1.51.82.21.51.51.5-1.31.41.3-1.21.31.31.2-1.2
Se content in liver0.30.40.6-0.5-0.6-0.50.6-0.5-0.70.6-0.5-0.5-0.80.7
Sr content in liver7.16.57.3-2.5-2.6-2.62.7-2.6-2.52.4-2.6-2.6-2.72.3
Zn content in liver4.75.26.0-2.4-2.3-2.32.4-2.2-2.32.3-2.1-2.1-2.42.1
Bone: minimum diameter0.61.11.61.01.01.3-1.21.20.7-0.71.31.31.1-0.5
Time in familiar zone, hab. session 10.00.00.1-0.2-0.2-0.00.1-0.1-0.20.10.10.1-0.20.1
Time in novel zone, hab. session 11.51.41.61.21.31.1-1.21.21.3-1.21.11.11.1-1.3
Total zone transitions, hab. session 10.40.50.7-0.7-0.7-0.80.7-0.8-0.60.6-0.8-0.8-0.50.6
Total locomotion distance, hab. session 10.00.00.30.10.10.00.00.1-0.10.10.00.0-0.50.1
Locomotion velocity, hab. session 10.30.40.9-0.5-0.5-0.60.7-0.6-0.60.7-0.6-0.6-1.00.6
Time in familiar zone, hab. session 20.80.81.10.80.80.8-0.90.90.9-1.01.01.00.9-1.1
Time in novel zone, hab. session 20.90.91.1-0.8-0.8-0.91.0-0.9-1.01.0-1.0-1.0-0.91.1
Total zone transitions, hab. session 21.31.61.9-1.4-1.3-1.31.3-1.3-1.31.3-1.3-1.3-1.01.2
Total locomotion distance, hab. session 20.20.20.6-0.4-0.4-0.30.5-0.4-0.40.5-0.4-0.4-0.80.4
Locomotion velocity, hab. session 20.10.10.3-0.3-0.2-0.20.3-0.2-0.30.4-0.2-0.2-0.60.4
Novel to familiar place preference ratio2.42.53.1-1.5-1.5-1.61.5-1.7-1.61.6-1.8-1.8-1.01.7
Novelty place preference1.51.52.0-1.1-1.1-1.21.2-1.3-1.21.3-1.4-1.4-0.81.4
Time in novel zone, NPP test1.71.72.2-1.2-1.2-1.31.3-1.3-1.31.4-1.5-1.5-1.11.4
Total zone transitions, NPP test1.42.12.4-1.5-1.4-1.51.5-1.5-1.41.4-1.5-1.5-1.21.3
Total locomotion distance, NPP test0.20.30.4-0.4-0.4-0.50.5-0.5-0.40.5-0.6-0.6-0.40.5
Locomotion velocity, NPP test0.10.10.3-0.4-0.3-0.50.3-0.4-0.30.3-0.5-0.50.00.3
Intraocular pressure0.10.20.40.40.40.3-0.30.40.5-0.50.40.4-0.2-0.6
Delta distance traveled before/after self-admin0.70.81.11.01.00.9-0.90.91.0-0.90.80.70.8-0.9
Delta ambulatory time before/after self-admin1.01.11.71.31.21.1-1.01.01.1-1.10.80.80.9-1.1
Parametrial fat weight1.42.83.81.71.61.9-1.91.81.5-1.41.71.81.6-1.1
Pavlov. Cond. lever latency0.91.11.61.31.21.0-1.01.11.2-1.20.90.90.5-1.2
Pavlov. Cond. magazine entry latency0.81.01.5-1.2-1.2-0.90.9-0.9-1.21.1-0.7-0.7-1.01.1
Pavlov. Cond. change in total contacts0.20.20.5-0.7-0.7-0.40.4-0.4-0.60.4-0.1-0.1-0.40.4
Pavlov. Cond. index score0.40.50.9-1.0-0.9-0.60.6-0.6-0.80.7-0.4-0.4-0.50.7
Pavlov. Cond. latency score0.30.30.7-0.9-0.8-0.50.5-0.6-0.70.6-0.3-0.3-0.20.6
Pavlov. Cond. lever contacts0.10.10.3-0.5-0.5-0.30.3-0.4-0.50.4-0.2-0.20.10.5
Pavlov. Cond. magazine entry number0.50.61.21.11.10.7-0.70.70.9-0.70.40.40.8-0.6
Pavlov. Cond. intertrial magazine entries0.00.00.2-0.3-0.2-0.50.1-0.2-0.0-0.0-0.1-0.10.1-0.1
Pavlov. Cond. lever-magazine prob. diff.0.50.61.1-1.1-1.0-0.80.8-0.8-0.90.8-0.6-0.6-0.70.8
Pavlov. Cond. response bias0.50.61.1-1.0-1.0-0.70.7-0.7-0.90.8-0.5-0.5-0.80.7
Pavlov. Cond. lever latency0.40.51.90.80.80.5-0.70.50.8-0.70.30.31.4-0.7
Pavlov. Cond. magazine entry latency4.75.49.7-2.6-2.5-2.22.4-2.2-2.42.2-1.8-1.8-3.12.1
Pavlov. Cond. change in total contacts1.11.54.0-1.5-1.5-1.01.2-0.9-1.31.1-0.5-0.4-2.01.0
Pavlov. Cond. index score2.53.27.3-2.0-2.0-1.61.8-1.5-2.01.7-1.1-1.1-2.71.6
Pavlov. Cond. latency score2.42.96.5-1.9-1.9-1.51.7-1.5-1.91.7-1.0-1.1-2.51.6
Pavlov. Cond. lever contacts0.40.52.8-0.8-0.8-0.50.7-0.4-0.70.5-0.1-0.1-1.70.4
Pavlov. Cond. magazine entry number7.49.114.63.33.22.8-3.12.83.2-2.92.42.43.8-2.8
Pavlov. Cond. intertrial magazine entries1.82.33.31.51.71.4-1.61.41.6-1.51.51.31.8-1.5
Pavlov. Cond. lever-magazine prob. diff.2.83.68.0-2.2-2.1-1.71.9-1.6-2.11.8-1.2-1.2-2.81.7
Pavlov. Cond. response bias1.52.15.6-1.6-1.6-1.21.5-1.2-1.51.3-0.9-0.9-2.41.2
Time in closed arm before self-admin0.00.10.20.1-0.00.2-0.30.20.1-0.10.40.30.2-0.1
Time in closed arm after self-admin0.30.30.70.90.70.6-0.50.60.5-0.40.40.30.5-0.4
Time in open arm before self-admin0.80.81.41.21.20.9-0.80.71.1-0.90.30.41.2-0.9
Time in open arm after self-admin0.00.00.1-0.2-0.1-0.30.1-0.20.2-0.2-0.2-0.1-0.1-0.3
Bone: periosteal estimation0.10.10.30.10.10.4-0.50.30.0-0.00.50.50.50.1
Bone: periosteal perimeter0.00.10.2-0.0-0.00.2-0.30.20.0-0.10.40.40.2-0.0
Bone: post-yield work0.30.40.80.40.40.7-0.80.70.1-0.10.90.80.90.1
Progressive ratio test 1 active lever presses1.31.31.71.11.11.3-1.21.31.1-1.11.21.21.1-1.1
Progressive ratio test 1 breakpoint1.51.62.01.21.21.4-1.31.41.2-1.21.31.31.1-1.2
Progressive ratio test 1 inactive lever presses0.40.40.7-0.4-0.5-0.40.6-0.5-0.70.8-0.7-0.6-0.80.8
Progressive ratio test 2 active lever presses1.11.21.71.01.01.3-1.21.20.9-1.01.31.20.9-0.9
Progressive ratio test 2 breakpoint2.02.22.91.51.41.6-1.61.61.4-1.41.71.51.5-1.3
Progressive ratio test 2 inactive lever presses0.20.30.70.40.40.8-0.50.60.2-0.20.70.70.1-0.1
Incentive Sensitization - Responses0.10.10.1-0.3-0.3-0.20.1-0.3-0.30.30.1-0.3-0.10.4
Incentive Sensitization - Breakpoint0.00.00.1-0.2-0.2-0.10.0-0.2-0.30.30.1-0.10.00.3
Sum of active levers in priming session hrs 5-60.70.61.4-1.2-1.1-0.80.8-0.8-0.80.6-0.5-0.5-0.90.5
Progressive ratio0.00.00.10.10.00.2-0.10.2-0.1-0.00.30.3-0.20.0
Food seeking constrained by brief footshock0.10.10.20.50.30.2-0.20.20.3-0.30.10.10.4-0.3
Seeking ratio, punishment vs. effort0.00.00.10.20.2-0.10.1-0.10.2-0.1-0.4-0.40.3-0.1
Retroperitoneal fat weight2.37.510.93.12.92.9-3.02.82.6-2.42.32.53.3-2.0
Reaction time number correct0.30.40.6-0.7-0.8-0.70.7-0.7-0.60.6-0.7-0.6-0.20.5
Reaction time mean minus median0.30.41.2-0.7-0.8-0.70.6-0.5-0.50.4-0.4-0.3-1.10.3
Reaction time mean minus median AUC0.10.10.7-0.4-0.4-0.50.3-0.2-0.1-0.0-0.2-0.1-0.9-0.2
Reaction time num false alarms0.20.20.80.50.60.3-0.30.20.6-0.50.10.10.9-0.5
Reaction time num false alarms AUC0.10.10.3-0.00.1-0.40.2-0.40.10.1-0.6-0.60.50.1
Reaction time trials correct on left0.30.40.6-0.7-0.8-0.70.7-0.7-0.60.6-0.7-0.6-0.20.5
Reaction time trials on left0.30.40.6-0.7-0.8-0.70.7-0.7-0.60.6-0.7-0.7-0.20.5
Reaction time mean0.10.10.9-0.0-0.20.1-0.00.30.1-0.20.40.5-0.9-0.4
Reaction time mean AUC0.20.20.60.1-0.00.4-0.20.50.3-0.40.70.8-0.7-0.6
Median of all reaction times0.10.11.0-0.3-0.4-0.00.20.1-0.20.10.10.3-1.0-0.0
Reaction time omissions0.10.10.2-0.3-0.4-0.40.3-0.3-0.10.1-0.4-0.3-0.1-0.0
Reaction time false alarm rate0.10.10.40.40.60.2-0.30.10.4-0.3-0.0-0.00.7-0.3
Reaction time premature initiation rate3.85.16.6-2.3-2.3-2.02.2-2.3-2.42.5-2.4-2.3-1.52.6
Reaction time premature initiations4.66.57.4-2.6-2.7-2.42.6-2.6-2.62.7-2.7-2.6-1.62.7
Std. dev. reaction times0.10.10.40.10.00.1-0.20.30.3-0.50.40.5-0.5-0.6
Reaction time trials completed0.30.40.6-0.7-0.8-0.70.7-0.7-0.60.6-0.7-0.7-0.20.5
Reaction time trials AUC0.20.30.4-0.6-0.7-0.60.6-0.6-0.50.5-0.6-0.6-0.10.4
Run reversals in cocaine runway, females0.80.81.5-0.7-0.6-0.70.8-0.9-0.91.1-0.9-1.0-0.51.2
Run reversals in cocaine runway, males0.80.82.90.80.80.6-1.00.70.9-0.90.60.61.7-0.8
Latency to leave start box in cocaine runway0.30.41.00.50.60.7-0.70.50.3-0.30.60.61.0-0.1
Latency to leave start box in cocaine runway, F0.00.00.2-0.2-0.2-0.10.1-0.2-0.30.3-0.1-0.10.20.4
Latency to leave start box in cocaine runway, M3.73.54.61.81.92.0-2.01.81.8-1.71.91.82.2-1.6
Std. dev. time between licks in bursts0.10.20.40.50.40.5-0.40.40.5-0.40.10.30.6-0.4
Total sessions with >9 infusions0.91.01.81.31.11.3-1.01.20.8-0.80.91.00.5-0.7
Short access day 1 total inactive lever presses0.60.71.20.91.01.1-0.90.90.7-0.60.80.80.7-0.5
Short access day 10 total inactive lever presses2.02.23.31.81.71.6-1.41.61.5-1.41.31.61.2-1.4
Short access day 1 total infusions0.50.61.10.90.91.1-0.70.80.7-0.60.70.70.3-0.6
Short access day 10 total infusions0.10.10.40.30.30.6-0.30.3-0.10.20.30.2-0.20.4
Short access total infusions0.10.10.50.50.50.7-0.30.40.2-0.10.30.3-0.00.0
Short access day 1 locomotion0.20.30.5-0.1-0.5-0.10.5-0.4-0.60.6-0.6-0.5-0.70.7
Short access day 10 total locomotion0.10.20.5-0.1-0.10.10.3-0.2-0.50.6-0.1-0.3-0.70.7
Short access total locomotion0.60.61.4-0.5-0.7-0.30.7-0.6-1.01.1-0.8-0.6-1.11.2
One hour access (0.3 mA shock)3.33.85.11.92.12.2-2.02.01.8-1.82.32.11.5-1.7
Compulsive drug intake0.80.81.3-0.8-0.5-1.11.0-1.1-0.60.7-1.1-1.1-0.70.6
One hour access (shock baseline)4.45.16.82.02.12.5-2.42.42.1-2.12.62.61.9-2.0
Social response proportion0.10.10.7-0.3-0.3-0.20.1-0.4-0.20.3-0.2-0.50.80.3
Social responses0.10.10.7-0.1-0.2-0.20.1-0.30.0-0.0-0.2-0.30.9-0.1
Social time0.00.00.10.10.2-0.10.1-0.20.2-0.2-0.1-0.30.0-0.3
Soleus weight2.88.18.82.72.82.7-2.92.92.9-2.93.03.02.6-2.8
Bone: stiffness0.40.71.3-1.1-1.1-0.80.7-0.8-1.00.9-0.6-0.6-0.30.9
Tibialis anterior weight10.636.338.2-6.1-6.1-6.26.1-6.2-6.05.9-6.2-6.1-5.55.8
Time to tail flick, vehicle, before self-admin0.60.61.1-0.8-0.7-0.60.7-0.8-0.91.0-0.7-0.8-0.81.1
Time to tail flick, vehicle, after self-admin0.70.71.0-0.5-0.8-0.60.9-0.8-0.91.0-1.0-0.9-0.91.0
Time to tail flick, test, before self-admin0.30.30.6-0.3-0.0-0.40.4-0.6-0.50.6-0.6-0.7-0.10.8
Time to tail flick, test, after self-admin0.20.20.30.30.50.2-0.40.30.5-0.50.40.30.6-0.5
Delta time to tail flick, vehicle, before/after SA0.00.00.10.0-0.2-0.10.2-0.1-0.10.1-0.3-0.10.00.1
Delta time to tail flick, test, before/after SA0.10.10.40.0-0.1-0.0-0.10.20.3-0.40.30.4-0.1-0.6
Tibia length1.44.05.4-2.3-2.3-2.11.9-2.0-2.22.1-1.8-1.7-1.32.1
Ambulatory time before self-admin1.51.62.7-1.6-1.6-1.41.2-1.2-1.31.2-0.9-0.9-1.21.1
Ambulatory time after self-admin0.10.10.3-0.4-0.5-0.20.2-0.2-0.50.4-0.0-0.1-0.40.4
Bone: tissue strength0.60.60.70.70.70.8-0.80.80.8-0.80.80.80.9-0.8
Total heroin consumption3.64.24.9-2.2-2.2-2.22.2-2.1-1.91.8-2.1-2.1-2.01.6
Bone: trabecular number0.50.71.2-0.9-0.9-0.70.8-0.8-1.01.0-0.8-0.8-0.61.1
Bone: trabecular spacing0.30.40.90.50.50.5-0.40.60.7-0.80.60.6-0.0-0.9
Bone: trabecular thickness0.50.61.10.60.60.7-0.90.80.6-0.70.90.91.1-0.6
Bone: trabecular tissue density3.95.55.92.42.42.3-2.42.32.4-2.42.32.32.1-2.4
Water consumed over 24 hours0.20.20.4-0.6-0.5-0.40.5-0.6-0.50.5-0.5-0.6-0.10.4
Number of responses in last shaping day0.10.10.3-0.0-0.3-0.20.4-0.2-0.20.3-0.5-0.4-0.30.2