Hub : Genes

Fth1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Fth1 0.34 0.12 0.0e+00 0.45 0.44 0.44 0.44 2.0e-46 1.7e-44 1.2e-44 4.9e-45
2 BLA gene expression Fth1 0.33 0.13 0.0e+00 0.35 0.35 0.34 0.35 3.3e-19 3.6e-19 6.5e-19 2.2e-19
3 pVTA gene expression Fth1 0.1 0.06 2.1e-10 0.12 0.13 0.11 0.12 5.5e-10 1.9e-10 3.1e-09 3.2e-10
4 IC gene expression Fth1 0.26 0.12 5.4e-11 0.18 0.18 0.15 0.18 4.7e-08 4.4e-08 7.4e-07 5.1e-08
5 Liver mRNA stability Fth1 0.1 0.05 7.8e-12 0.08 0.08 0.07 0.08 2.8e-09 2.3e-09 1.0e-08 7.5e-09
6 LHb gene expression Fth1 0.14 0.11 8.1e-03 0.04 0.04 0.02 0.03 4.6e-02 3.8e-02 9.8e-02 5.4e-02
7 Liver gene expression Fth1 0.07 0.04 2.0e-08 0.05 0.06 0.05 0.05 4.8e-06 5.6e-07 5.6e-06 1.4e-06
8 PL gene expression Fth1 0.38 0.19 0.0e+00 0.37 0.4 0.39 0.39 4.3e-42 3.2e-46 1.4e-45 3.0e-45
9 OFC gene expression Fth1 0.35 0.19 3.0e-05 0.08 0.14 0.1 0.13 5.0e-03 2.8e-04 2.3e-03 5.5e-04
10 NAcc gene expression Fth1 0.15 0.07 0.0e+00 0.24 0.24 0.24 0.24 2.0e-36 7.9e-36 2.6e-36 2.8e-35
11 IL gene expression Fth1 0.53 0.17 8.4e-11 0.22 0.34 0.3 0.29 6.1e-06 7.3e-09 6.7e-08 9.0e-08
12 Brain mRNA stability Fth1 0.07 0.05 2.4e-06 0.06 0.06 0.06 0.06 1.1e-06 6.1e-06 1.5e-06 2.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.30.5-0.60.60.40.4-0.70.60.70.60.7-0.50.7-0.5
Area under the delay curve0.10.20.3-0.20.20.20.3-0.40.40.50.50.4-0.50.6-0.5
BMI with tail2.68.912.2-2.82.82.72.4-3.43.03.32.83.5-2.93.1-3.0
BMI without tail0.42.23.1-1.11.11.41.3-1.51.51.51.31.7-1.81.5-1.7
Body weight3.616.018.6-3.83.83.83.6-4.24.04.23.94.3-4.04.2-4.2
Weight adjusted by age0.41.11.6-1.11.01.21.1-1.21.11.10.81.2-0.60.9-1.1
Bone surface1.63.13.8-1.91.91.61.5-2.01.71.91.91.8-1.51.9-1.6
Bone volume0.51.01.4-1.21.20.80.7-1.20.91.21.11.1-0.71.1-0.8
Breakpoint value in progressive ratio session1.62.93.7-1.71.71.91.9-1.61.81.61.71.6-1.61.6-1.7
Number of licking bursts0.00.00.00.0-0.0-0.00.00.00.00.00.1-0.0-0.1-0.0-0.0
Context. condit. distance diff. score0.10.10.20.5-0.5-0.2-0.30.2-0.3-0.2-0.5-0.20.3-0.30.2
Locomotion velocity, session 10.00.00.1-0.10.10.30.2-0.20.20.10.10.3-0.20.2-0.2
Locomotion distance, session 10.81.11.4-0.90.91.11.0-1.11.01.00.91.2-1.01.0-1.1
Locomotion velocity, session 23.23.94.1-2.02.01.91.9-2.02.02.02.02.0-1.92.0-1.9
Locomotion distance, session 20.50.71.0-0.60.60.90.9-0.80.90.80.80.9-1.00.8-1.0
Locomotion velocity, session 30.40.50.8-0.50.50.50.4-0.80.60.90.50.9-0.70.8-0.7
Locomotion distance, session 30.00.00.0-0.20.2-0.00.0-0.10.10.10.10.1-0.10.2-0.1
Stereotopy head waving bouts, day 30.00.10.20.2-0.2-0.0-0.1-0.20.10.20.10.4-0.40.2-0.4
Stereotopy head waving duration, day 30.10.10.30.1-0.10.20.2-0.30.30.30.20.4-0.50.3-0.5
Locomotion velocity, session 70.00.00.1-0.20.20.10.1-0.20.20.30.30.2-0.30.3-0.2
Locomotion distance, session 70.00.00.10.2-0.2-0.1-0.00.00.00.1-0.00.1-0.20.1-0.2
Stereotopy head waving bouts, day 70.20.20.3-0.50.50.40.4-0.60.50.50.50.5-0.30.5-0.4
Stereotopy head waving duration, day 71.62.02.2-1.41.41.41.4-1.51.41.41.51.4-1.31.5-1.4
Locomotion velocity, session 80.00.00.1-0.00.00.20.30.00.20.10.10.0-0.40.2-0.4
Locomotion distance, session 80.10.10.20.5-0.5-0.2-0.30.2-0.2-0.2-0.3-0.10.2-0.20.1
Degree of sensitization distance0.00.00.20.1-0.10.10.0-0.30.20.30.10.4-0.20.1-0.3
Degree of sensitization stereotypy1.01.11.4-1.21.21.11.0-1.21.01.11.11.1-0.81.0-0.9
Conditioned locomotion0.60.71.0-0.80.80.80.9-0.80.90.80.90.8-1.00.9-0.9
Cocaine response after cond. corrected0.20.40.50.7-0.7-0.5-0.60.6-0.6-0.6-0.7-0.40.4-0.70.5
Cocaine response after cond. not corrected0.30.40.50.6-0.6-0.5-0.70.5-0.6-0.6-0.7-0.40.6-0.70.7
Cocaine response before conditioning0.10.20.6-0.80.80.30.2-0.50.20.30.40.20.30.30.2
Saline control response2.94.04.6-2.12.12.02.1-1.92.01.92.01.9-2.02.0-2.0
Bone: connectivity density1.62.52.9-1.61.61.51.4-1.71.61.71.61.7-1.51.7-1.5
Bone: cortical apparent density0.20.40.5-0.70.70.70.7-0.50.60.50.60.5-0.50.5-0.6
Bone: cortical area0.61.01.5-1.21.20.90.8-1.00.91.01.00.9-0.81.0-0.8
Bone: cortical porosity0.00.00.1-0.00.00.30.40.10.2-0.00.1-0.1-0.20.0-0.2
Bone: cortical porosity0.10.20.4-0.30.30.50.6-0.20.40.30.40.2-0.50.3-0.5
Bone: cortical thickness3.04.95.9-2.42.42.32.4-2.02.22.02.31.9-2.22.2-2.2
Bone: cortical thickness0.30.30.4-0.70.70.60.7-0.40.50.40.50.4-0.60.5-0.6
Bone: cortical tissue density0.40.60.9-0.80.80.90.9-0.70.80.70.70.6-0.70.7-0.7
Condit. Reinf. active minus inactive responses1.01.11.4-1.21.21.11.0-1.11.01.00.91.1-0.90.9-0.9
Condit. Reinf. active-inactive response ratio0.40.40.7-0.70.70.80.7-0.60.60.50.50.6-0.60.5-0.6
Condit. Reinf. active responses0.81.01.4-1.21.21.00.8-1.21.01.00.81.2-0.80.9-0.7
Condit. Reinf. inactive responses0.00.00.20.0-0.0-0.2-0.4-0.1-0.20.0-0.30.10.3-0.10.4
Incentive salience index mean1.01.31.7-1.31.31.10.9-1.31.11.21.01.3-1.01.1-0.9
Condit. Reinf. lever presses0.60.81.3-1.11.10.70.6-1.10.81.00.91.0-0.71.0-0.7
Condit. Reinf. active minus inactive responses0.10.20.50.2-0.2-0.3-0.40.3-0.4-0.4-0.3-0.40.6-0.50.7
Condit. Reinf. active-inactive response ratio0.20.30.70.5-0.5-0.6-0.70.3-0.6-0.4-0.5-0.40.8-0.60.8
Condit. Reinf. active responses0.00.10.2-0.40.40.20.1-0.30.20.20.20.20.00.20.1
Condit. Reinf. inactive responses0.10.10.2-0.50.50.30.3-0.20.20.20.20.2-0.20.3-0.2
Condit. Reinf. lever presses0.60.81.3-1.11.10.80.7-1.10.91.00.91.0-0.60.9-0.5
Condit. Reinf. lever reinforcers received0.10.20.4-0.60.60.50.4-0.50.40.40.40.4-0.20.3-0.1
Conditioned reinforcement - actives0.10.30.70.5-0.5-0.4-0.50.4-0.5-0.5-0.6-0.50.8-0.60.8
Conditioned reinforcement - inactives0.00.10.30.2-0.2-0.2-0.4-0.1-0.20.0-0.20.00.6-0.20.4
Conditioned locomotion1.32.02.61.6-1.6-1.5-1.61.1-1.4-1.1-1.4-1.11.6-1.21.4
Patch foraging indifference point 0 sec0.30.81.1-0.80.80.90.9-0.90.90.91.00.9-1.00.9-0.9
Patch foraging indifference point AUC0.61.52.0-1.41.41.31.3-1.21.21.21.41.1-0.91.2-1.0
Delay disc. indifference point, 0s delay0.10.10.40.6-0.6-0.4-0.50.1-0.2-0.1-0.30.00.2-0.10.0
Delay disc. indifference point, 16s delay0.10.10.1-0.40.40.20.2-0.40.30.40.40.3-0.20.3-0.2
Delay disc. indifference point, 2s delay0.10.20.40.4-0.4-0.6-0.70.2-0.4-0.2-0.2-0.20.5-0.20.4
Delay disc. indifference point, 24s delay0.10.10.3-0.20.20.20.3-0.30.30.40.40.4-0.50.5-0.4
Delay disc. indifference point, 4s delay0.60.71.3-0.50.50.50.7-0.70.80.90.90.8-1.11.0-1.0
Delay disc. indifference point, 8s delay0.10.10.40.6-0.6-0.4-0.20.4-0.3-0.3-0.1-0.40.1-0.20.0
Indifference point function ln k1.54.65.72.3-2.3-2.2-2.32.1-2.2-2.0-2.4-1.91.9-2.12.0
Indifference point function log k1.54.65.72.3-2.3-2.2-2.32.1-2.2-2.0-2.4-1.91.9-2.12.0
Patch foraging total patch changes 0 sec0.30.81.2-0.80.80.91.0-0.80.90.80.90.8-1.10.9-1.0
Patch foraging total patch changes 12 sec6.38.59.8-2.92.93.13.1-2.83.02.83.02.7-2.92.9-2.9
Patch foraging total patch changes 18 sec0.30.70.9-0.90.90.91.0-0.80.90.81.00.8-0.70.9-0.8
Patch foraging total patch changes 24 sec2.48.38.8-2.82.82.92.9-2.92.92.93.02.9-2.93.0-2.9
Patch foraging total patch changes 6 sec1.01.61.8-1.31.31.21.3-1.31.31.31.31.2-1.41.3-1.3
Patch foraging time to switch 0 sec0.10.50.7-0.80.80.60.5-0.90.70.80.70.8-0.60.8-0.5
Patch foraging water rate 0 sec0.31.01.21.0-1.0-0.9-0.91.1-1.0-1.1-1.0-1.10.9-1.01.0
Patch foraging water rate 12 sec0.72.93.71.9-1.9-1.7-1.61.8-1.7-1.7-1.8-1.61.5-1.71.5
Patch foraging water rate 18 sec0.30.71.01.0-1.0-0.9-0.80.8-0.8-0.8-0.9-0.70.5-0.70.6
Patch foraging water rate 24 sec1.41.92.41.3-1.3-1.4-1.31.5-1.4-1.5-1.6-1.41.1-1.51.3
Patch foraging water rate 6 sec1.21.82.31.5-1.5-1.3-1.21.4-1.3-1.4-1.4-1.41.2-1.31.0
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.10.10.10.1-0.30.20.30.20.3-0.20.2-0.1
Distance traveled before self-admin1.02.23.2-1.81.81.41.3-1.71.41.61.51.5-1.21.5-1.2
Distance traveled after self-admin0.20.40.5-0.60.60.70.7-0.60.60.60.60.6-0.50.6-0.5
Extensor digitorum longus weight6.425.526.7-5.05.05.04.9-5.15.15.15.05.2-5.15.1-5.0
Bone: elastic displacement0.30.30.60.6-0.6-0.4-0.30.8-0.5-0.7-0.6-0.70.4-0.60.4
Bone: elastic work0.91.21.7-1.11.11.21.3-0.91.10.91.11.0-1.31.1-1.2
Bone: endosteal estimation0.92.23.71.5-1.5-1.8-1.91.1-1.5-1.1-1.6-1.11.6-1.31.6
Bone: endosteal perimeter1.53.85.91.9-1.9-2.2-2.41.5-2.0-1.5-1.9-1.62.2-1.72.2
Epididymis fat weight0.52.54.11.5-1.5-1.9-2.01.2-1.6-1.3-1.5-1.31.8-1.51.7
Delta time in closed arm before/after self-admin2.22.13.5-0.91.01.51.6-1.21.51.41.41.4-1.71.4-1.9
Delta time in open arm before/after self-admin1.41.62.7-1.61.61.31.2-1.41.21.31.21.2-0.91.1-0.9
Diff in mean of infusions in LGA sessions1.83.34.0-1.71.71.92.0-1.71.91.71.91.7-1.91.8-1.9
Delay discount exponential model param0.10.20.40.2-0.2-0.2-0.30.4-0.4-0.5-0.6-0.50.5-0.60.5
Extinction: sum of active levers before priming2.64.04.2-2.02.02.02.0-2.02.02.02.12.0-1.92.0-2.0
Active lever presses in extinction session 62.42.53.8-1.91.91.61.5-1.61.51.51.61.4-1.31.4-1.2
Bone: final force1.22.02.6-1.61.61.31.2-1.51.41.51.31.5-1.31.5-1.2
Bone: final moment1.32.12.7-1.61.61.41.3-1.51.41.51.41.5-1.31.5-1.3
Food consumed during 24 hour testing period0.20.40.50.4-0.4-0.6-0.60.6-0.6-0.7-0.7-0.70.7-0.60.7
Glucose2.43.84.92.2-2.2-2.1-2.21.8-2.0-1.8-1.9-1.61.8-1.81.9
Heart weight0.10.20.60.7-0.7-0.6-0.60.3-0.4-0.2-0.4-0.1-0.0-0.20.0
Delay discount hyperbolic model param0.10.10.20.1-0.1-0.1-0.20.3-0.3-0.4-0.5-0.40.4-0.50.4
Intermittent access intake day 1-15 change0.42.33.61.5-1.5-1.5-1.51.3-1.5-1.4-1.5-1.51.9-1.51.7
Intermittent access intake escalation0.52.94.41.7-1.7-1.6-1.71.5-1.7-1.6-1.7-1.62.1-1.71.9
Intermittent access intake escalation 20.40.81.60.8-0.8-0.8-0.90.6-0.8-0.8-0.8-0.81.3-0.81.1
Intermitt. access day 1 inactive lever presses0.11.01.81.0-1.0-0.9-1.00.8-1.0-0.9-1.1-0.91.3-1.01.0
Intermitt. access day 15 inactive lever presses0.20.81.8-0.90.90.70.4-1.30.91.20.91.2-0.31.0-0.6
Intermitt. access escalation Index0.20.71.21.1-1.1-0.9-0.80.9-0.8-0.8-0.7-0.90.8-0.80.7
Intermittent access day 1 total infusions0.10.20.70.6-0.6-0.6-0.8-0.2-0.30.1-0.40.20.5-0.10.4
Intermittent access day 15 total infusions1.74.15.72.3-2.3-2.1-2.41.5-2.0-1.6-2.0-1.62.4-1.82.2
Intermittent access terminal intake (last 3 days)0.61.01.91.2-1.2-1.1-1.40.4-0.9-0.5-0.9-0.51.4-0.81.2
Intermittent access total infusions0.70.91.81.2-1.2-1.1-1.30.4-0.9-0.5-0.9-0.41.1-0.71.0
Intermittent access day 1 locomotion0.00.10.20.1-0.1-0.1-0.3-0.40.10.4-0.00.50.10.2-0.1
Intermittent access day 15 total locomotion0.00.10.50.3-0.3-0.3-0.6-0.4-0.20.2-0.30.30.7-0.00.3
Intermittent access total locomotion0.20.20.80.3-0.3-0.5-0.9-0.5-0.30.3-0.30.40.7-0.00.5
Intermittent access standard deviation0.21.01.51.2-1.2-0.8-0.90.8-0.9-0.9-1.0-0.81.2-1.00.9
Left kidney weight0.00.41.00.6-0.6-0.9-1.00.3-0.6-0.3-0.5-0.30.6-0.30.6
Right kidney weight0.00.20.50.5-0.5-0.7-0.70.3-0.5-0.3-0.3-0.30.4-0.30.4
Cocaine induced anxiety0.00.10.2-0.40.40.30.2-0.20.20.10.10.1-0.00.1-0.0
Post-drug Anxiety0.30.30.6-0.80.80.50.5-0.60.50.60.50.6-0.40.5-0.4
Baseline Anxiety0.20.40.6-0.50.50.50.5-0.60.60.70.60.7-0.80.7-0.8
Tail length0.21.22.0-0.90.91.21.3-0.81.10.91.10.8-1.31.1-1.4
Length with tail1.35.86.8-2.32.32.42.4-2.42.42.42.42.3-2.32.5-2.6
Length without tail1.89.410.1-3.03.03.03.0-3.13.13.13.13.1-3.03.1-3.2
Times rat made contact with spout0.10.20.3-0.40.40.50.6-0.20.40.30.30.3-0.50.3-0.5
Lifetime Intake0.50.61.31.1-1.1-0.9-1.10.3-0.7-0.4-0.7-0.30.9-0.50.7
Liver weight, left1.11.92.21.5-1.5-1.3-1.31.4-1.3-1.4-1.4-1.31.3-1.41.2
Liver weight, right1.52.53.11.8-1.8-1.7-1.71.5-1.6-1.5-1.6-1.41.5-1.51.5
Locomotor activity0.50.81.31.1-1.1-0.8-0.61.1-0.8-1.0-0.7-1.00.6-0.80.4
Locomotor testing distance0.40.91.31.1-1.1-0.9-0.91.1-0.9-1.1-0.8-0.90.8-0.90.6
Locomotor testing rearing0.41.41.61.2-1.2-1.1-1.11.2-1.2-1.3-1.2-1.21.2-1.21.1
Locomotion in novel chamber1.62.12.81.5-1.5-1.5-1.61.2-1.5-1.3-1.3-1.31.7-1.31.5
Locomotion in novel chamber post-restriction0.82.53.01.7-1.7-1.5-1.41.6-1.5-1.6-1.5-1.61.4-1.61.5
Fecal boli incidents, locomotor time 10.20.41.00.4-0.4-0.5-0.60.4-0.6-0.6-0.6-0.61.0-0.71.0
Change in fecal boli incidents, locomotor task0.80.91.31.1-1.1-1.1-1.11.0-1.0-0.9-1.0-0.80.5-0.70.4
Time >=10cm from walls, locomotor time 11.82.33.41.4-1.4-1.5-1.71.2-1.5-1.3-1.6-1.31.8-1.61.6
Bouts of movement, locomotor time 10.20.30.8-0.60.60.80.9-0.30.60.30.50.2-0.30.2-0.6
Total resting periods, locomotor time 10.20.20.6-0.60.60.70.8-0.30.50.30.50.2-0.20.2-0.5
Rest time, locomotor task time 11.42.22.41.5-1.5-1.5-1.41.5-1.5-1.5-1.4-1.61.5-1.61.4
Distance moved, locomotor task time 10.10.40.5-0.60.60.60.5-0.70.60.70.50.7-0.50.7-0.3
Vertical activity count, locomotor time 10.10.50.60.7-0.7-0.7-0.70.7-0.7-0.7-0.7-0.70.8-0.60.8
Time >=10cm from walls, locomotor time 20.10.30.90.1-0.1-0.4-0.50.4-0.5-0.5-0.5-0.60.6-0.61.0
Bouts of movement, locomotor time 20.41.42.0-1.21.21.41.3-1.21.21.11.01.2-1.10.9-1.2
Total resting periods, locomotor time 20.20.71.1-0.80.81.00.9-0.80.80.70.60.9-0.70.5-0.9
Rest time, locomotor task time 22.03.34.42.1-2.1-1.7-1.71.8-1.8-1.8-1.8-1.71.8-1.91.5
Distance moved, locomotor task time 20.30.50.8-0.90.90.70.7-0.60.70.60.70.5-0.70.7-0.3
Vertical activity count, locomotor time 20.00.00.10.0-0.0-0.10.10.4-0.1-0.3-0.0-0.4-0.1-0.10.1
Light reinforcement 10.00.20.40.2-0.2-0.4-0.40.3-0.4-0.4-0.3-0.40.5-0.40.6
Light reinforcement 20.20.40.80.3-0.3-0.8-0.90.3-0.6-0.4-0.5-0.50.8-0.50.9
Bone: marrow area1.12.74.21.7-1.7-1.9-2.11.3-1.7-1.3-1.7-1.31.7-1.41.7
Bone: maximum diameter0.10.10.3-0.50.50.10.0-0.50.20.50.30.4-0.10.4-0.1
Bone: maximum force1.73.44.4-2.02.01.71.5-2.11.82.01.82.0-1.62.0-1.6
Bone: maximum moment1.83.54.3-2.02.01.71.6-2.11.82.01.82.0-1.62.0-1.6
Mean time between licks in bursts0.10.30.8-0.40.40.60.7-0.40.60.50.40.6-0.90.5-0.8
Mean num. licks in bursts0.00.00.10.1-0.10.10.10.2-0.1-0.2-0.2-0.20.0-0.20.0
Cd content in liver0.70.81.00.8-0.8-0.9-0.90.8-0.9-0.9-0.8-0.81.0-0.81.0
Co content in liver0.70.81.10.9-0.9-0.8-0.61.1-0.9-1.0-0.9-1.00.8-1.00.8
Cu content in liver0.00.00.00.1-0.1-0.00.10.1-0.0-0.1-0.1-0.1-0.10.0-0.1
Fe content in liver0.00.00.00.1-0.1-0.0-0.10.0-0.0-0.0-0.10.0-0.0-0.0-0.0
K content in liver0.30.30.4-0.60.60.40.4-0.70.50.60.60.6-0.40.6-0.4
Mg content in liver0.00.00.1-0.10.1-0.0-0.0-0.20.10.20.20.2-0.20.2-0.2
Mn content in liver2.93.33.6-1.91.91.81.8-1.81.81.81.91.8-1.71.8-1.7
Na content in liver0.20.20.5-0.70.70.40.3-0.60.40.40.40.5-0.20.4-0.2
Rb content in liver2.63.03.31.8-1.8-1.8-1.71.8-1.7-1.8-1.8-1.71.5-1.71.7
Se content in liver0.10.10.1-0.20.20.20.2-0.40.30.40.30.3-0.10.2-0.2
Sr content in liver5.24.55.0-2.12.12.22.2-2.12.22.12.12.1-2.12.1-2.2
Zn content in liver3.33.84.2-1.91.92.02.0-1.92.01.92.02.0-2.02.0-2.0
Bone: minimum diameter0.61.12.11.0-1.0-1.3-1.50.7-1.1-0.8-1.0-0.81.3-0.91.2
Time in familiar zone, hab. session 10.00.00.0-0.20.20.10.0-0.20.10.10.00.10.10.10.1
Time in novel zone, hab. session 11.31.51.61.3-1.3-1.2-1.21.3-1.2-1.3-1.2-1.21.1-1.21.1
Total zone transitions, hab. session 10.30.40.6-0.50.50.70.8-0.60.70.60.70.6-0.70.6-0.8
Total locomotion distance, hab. session 10.00.00.00.1-0.1-0.0-0.1-0.1-0.00.1-0.00.10.0-0.00.0
Locomotion velocity, hab. session 10.20.30.5-0.50.50.60.5-0.60.60.60.60.7-0.60.6-0.6
Time in familiar zone, hab. session 20.70.81.00.7-0.7-0.8-0.80.9-0.9-0.9-0.8-1.01.0-0.90.9
Time in novel zone, hab. session 20.80.81.1-0.80.80.90.8-1.00.91.00.91.0-1.01.0-1.0
Total zone transitions, hab. session 21.21.51.7-1.31.31.21.2-1.21.21.21.31.2-1.21.3-1.2
Total locomotion distance, hab. session 20.10.20.3-0.40.40.40.3-0.50.40.40.40.5-0.40.4-0.4
Locomotion velocity, hab. session 20.10.10.1-0.30.30.20.1-0.30.20.30.20.4-0.30.3-0.2
Novel to familiar place preference ratio2.02.63.1-1.51.51.51.6-1.61.61.61.61.6-1.71.7-1.8
Novelty place preference1.21.61.9-1.11.11.21.2-1.21.31.31.21.3-1.41.3-1.4
Time in novel zone, NPP test1.41.72.2-1.11.11.31.3-1.31.31.41.31.4-1.41.4-1.5
Total zone transitions, NPP test1.42.02.3-1.41.41.51.5-1.31.41.31.51.3-1.41.4-1.5
Total locomotion distance, NPP test0.20.30.4-0.40.40.50.5-0.40.50.50.50.5-0.60.5-0.6
Locomotion velocity, NPP test0.10.20.3-0.30.30.40.4-0.30.40.30.50.3-0.50.4-0.5
Intraocular pressure0.10.20.30.4-0.4-0.3-0.30.5-0.4-0.5-0.5-0.50.5-0.60.4
Delta distance traveled before/after self-admin0.40.50.90.9-0.9-0.5-0.40.9-0.6-0.8-0.7-0.70.4-0.70.4
Delta ambulatory time before/after self-admin0.50.81.41.2-1.2-0.7-0.61.1-0.8-1.0-0.9-0.90.6-0.90.6
Parametrial fat weight1.33.25.01.9-1.9-2.2-2.21.5-1.8-1.4-1.6-1.51.9-1.51.8
Pavlov. Cond. lever latency0.70.91.21.1-1.1-0.9-0.81.1-0.9-1.0-1.0-1.00.8-1.10.8
Pavlov. Cond. magazine entry latency0.70.91.4-1.11.10.90.7-1.20.91.10.91.0-0.60.9-0.6
Pavlov. Cond. change in total contacts0.20.30.5-0.70.70.50.3-0.70.50.50.50.5-0.20.5-0.2
Pavlov. Cond. index score0.50.60.9-0.90.90.70.6-0.90.70.80.80.8-0.50.8-0.5
Pavlov. Cond. latency score0.40.50.7-0.90.90.60.5-0.80.60.70.70.7-0.40.7-0.5
Pavlov. Cond. lever contacts0.30.30.5-0.70.70.50.4-0.70.50.60.60.6-0.40.7-0.4
Pavlov. Cond. magazine entry number0.60.81.21.1-1.1-0.9-0.81.0-0.9-0.9-0.9-0.80.6-0.80.6
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.40.40.30.3-0.10.20.10.40.1-0.20.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.50.70.9-1.01.00.80.7-0.90.80.80.80.8-0.50.8-0.6
Pavlov. Cond. response bias0.70.91.3-1.11.10.90.8-1.10.91.00.90.9-0.60.9-0.7
Pavlov. Cond. lever latency0.30.50.90.9-0.9-0.7-0.50.9-0.7-0.8-0.6-0.80.3-0.60.3
Pavlov. Cond. magazine entry latency4.36.17.8-2.82.82.62.4-2.72.52.52.32.6-2.02.3-2.0
Pavlov. Cond. change in total contacts0.51.32.3-1.51.51.20.9-1.41.11.21.01.2-0.51.0-0.5
Pavlov. Cond. index score2.03.14.4-2.12.11.81.5-2.11.71.91.61.9-1.21.6-1.2
Pavlov. Cond. latency score1.82.94.2-2.02.01.71.5-2.01.71.81.61.9-1.11.6-1.2
Pavlov. Cond. lever contacts0.20.40.7-0.80.80.60.4-0.80.60.70.40.7-0.20.4-0.2
Pavlov. Cond. magazine entry number7.29.411.83.4-3.4-3.2-2.93.3-3.1-3.1-2.9-3.22.5-2.92.6
Pavlov. Cond. intertrial magazine entries0.92.02.31.5-1.5-1.5-1.41.5-1.4-1.5-1.3-1.51.4-1.41.3
Pavlov. Cond. lever-magazine prob. diff.2.33.55.0-2.22.22.01.6-2.21.92.01.72.0-1.31.7-1.3
Pavlov. Cond. response bias1.62.23.1-1.81.81.51.3-1.81.51.61.41.6-1.11.4-1.1
Time in closed arm before self-admin0.10.20.50.3-0.3-0.5-0.50.1-0.4-0.2-0.3-0.30.7-0.30.5
Time in closed arm after self-admin0.60.71.31.1-1.1-0.8-0.70.8-0.7-0.7-0.7-0.70.8-0.70.6
Time in open arm before self-admin0.50.61.21.1-1.1-0.8-0.61.1-0.8-0.9-0.8-0.80.2-0.70.2
Time in open arm after self-admin0.50.50.9-0.90.90.70.8-0.50.70.50.70.5-0.90.6-0.9
Bone: periosteal estimation0.00.10.40.1-0.1-0.5-0.6-0.0-0.3-0.0-0.3-0.10.5-0.10.5
Bone: periosteal perimeter0.00.10.30.0-0.0-0.4-0.5-0.0-0.3-0.1-0.2-0.10.5-0.10.4
Bone: post-yield work0.10.20.80.3-0.3-0.7-0.9-0.0-0.4-0.0-0.3-0.10.7-0.10.7
Progressive ratio test 1 active lever presses0.10.20.40.6-0.6-0.4-0.50.2-0.3-0.2-0.4-0.20.5-0.30.3
Progressive ratio test 1 breakpoint0.10.20.30.6-0.6-0.4-0.50.2-0.3-0.2-0.4-0.20.5-0.30.4
Progressive ratio test 1 inactive lever presses0.51.32.0-0.80.81.10.9-1.41.21.31.11.4-1.01.2-1.2
Progressive ratio test 2 active lever presses0.50.71.31.0-1.0-0.9-1.10.4-0.8-0.5-0.8-0.51.0-0.71.0
Progressive ratio test 2 breakpoint0.50.71.21.0-1.0-0.9-1.10.4-0.8-0.5-0.8-0.51.0-0.61.0
Progressive ratio test 2 inactive lever presses0.10.40.90.6-0.6-0.7-0.90.1-0.6-0.3-0.6-0.20.9-0.40.8
Incentive Sensitization - Responses0.20.50.9-0.70.70.50.3-1.00.60.90.60.9-0.60.7-0.3
Incentive Sensitization - Breakpoint0.10.30.8-0.60.60.40.2-0.90.50.80.50.8-0.40.6-0.2
Sum of active levers in priming session hrs 5-60.60.51.1-1.11.10.80.8-0.70.70.60.80.5-0.40.6-0.3
Progressive ratio0.00.00.10.1-0.1-0.2-0.4-0.1-0.10.1-0.10.10.3-0.00.3
Food seeking constrained by brief footshock0.00.00.10.3-0.3-0.2-0.20.2-0.2-0.2-0.3-0.10.1-0.20.2
Seeking ratio, punishment vs. effort0.00.10.30.1-0.10.20.20.10.1-0.00.00.1-0.50.1-0.4
Retroperitoneal fat weight3.214.117.34.2-4.2-4.1-4.13.5-3.8-3.4-3.6-3.53.8-3.53.5
Reaction time number correct0.10.30.4-0.60.60.60.6-0.50.50.40.50.5-0.50.5-0.6
Reaction time mean minus median0.10.50.7-0.80.80.80.8-0.70.70.60.70.6-0.50.5-0.5
Reaction time mean minus median AUC0.00.10.3-0.40.40.50.5-0.20.30.10.20.1-0.20.1-0.2
Reaction time num false alarms0.10.20.30.5-0.5-0.3-0.20.6-0.3-0.5-0.3-0.50.0-0.30.1
Reaction time num false alarms AUC0.00.10.40.0-0.00.30.50.10.20.00.30.0-0.60.2-0.6
Reaction time trials correct on left0.10.30.4-0.60.60.60.6-0.50.50.40.50.5-0.50.5-0.6
Reaction time trials on left0.10.30.4-0.60.60.60.6-0.50.50.50.50.5-0.60.6-0.7
Reaction time mean0.00.10.4-0.00.00.0-0.10.0-0.1-0.2-0.2-0.10.7-0.30.3
Reaction time mean AUC0.10.20.90.2-0.2-0.2-0.40.2-0.4-0.4-0.5-0.40.9-0.60.6
Median of all reaction times0.00.10.5-0.10.10.0-0.1-0.1-0.1-0.1-0.2-0.00.7-0.20.3
Reaction time omissions0.20.40.6-0.80.80.70.8-0.50.60.50.60.4-0.60.5-0.5
Reaction time false alarm rate0.00.10.20.4-0.4-0.2-0.10.4-0.2-0.3-0.1-0.3-0.1-0.1-0.1
Reaction time premature initiation rate3.85.96.7-2.32.32.22.2-2.52.42.62.32.6-2.52.6-2.4
Reaction time premature initiations2.37.07.5-2.62.62.62.5-2.72.62.72.52.7-2.72.7-2.7
Std. dev. reaction times0.00.10.20.0-0.00.10.00.2-0.1-0.3-0.2-0.30.4-0.30.3
Reaction time trials completed0.10.30.4-0.60.60.60.6-0.50.50.50.50.5-0.60.6-0.7
Reaction time trials AUC0.10.20.3-0.50.50.50.5-0.40.40.40.40.4-0.50.5-0.6
Run reversals in cocaine runway, females0.40.50.9-0.60.60.40.4-0.70.60.80.60.8-1.00.8-0.7
Run reversals in cocaine runway, males0.40.50.80.7-0.7-0.8-0.60.9-0.7-0.8-0.5-0.90.5-0.60.5
Latency to leave start box in cocaine runway0.30.40.80.7-0.7-0.9-0.90.4-0.6-0.4-0.5-0.40.7-0.40.6
Latency to leave start box in cocaine runway, F0.00.00.1-0.20.20.00.0-0.30.20.30.30.3-0.20.3-0.2
Latency to leave start box in cocaine runway, M2.42.32.81.6-1.6-1.7-1.71.4-1.5-1.4-1.5-1.41.5-1.41.5
Std. dev. time between licks in bursts0.10.10.20.4-0.4-0.4-0.40.5-0.4-0.4-0.4-0.30.2-0.30.3
Total sessions with >9 infusions0.50.61.31.1-1.1-0.7-0.80.5-0.7-0.6-0.8-0.50.8-0.70.6
Short access day 1 total inactive lever presses0.00.00.00.2-0.2-0.1-0.2-0.0-0.00.1-0.00.10.00.0-0.0
Short access day 10 total inactive lever presses0.10.60.80.8-0.8-0.6-0.60.9-0.8-0.9-0.9-0.80.8-0.90.7
Short access day 1 total infusions0.61.22.01.4-1.4-1.1-1.21.0-1.1-1.0-1.1-0.91.1-1.00.9
Short access day 10 total infusions0.10.20.40.6-0.6-0.5-0.7-0.1-0.30.0-0.40.10.4-0.10.4
Short access total infusions0.30.41.01.0-1.0-0.6-0.70.2-0.5-0.3-0.6-0.20.5-0.40.4
Short access day 1 locomotion0.10.20.40.7-0.7-0.3-0.40.2-0.3-0.3-0.3-0.30.5-0.30.2
Short access day 10 total locomotion0.00.10.3-0.20.20.0-0.2-0.50.10.4-0.10.6-0.00.20.1
Short access total locomotion0.00.10.10.3-0.3-0.2-0.4-0.2-0.10.2-0.20.20.4-0.00.1
One hour access (0.3 mA shock)0.81.01.70.9-0.9-1.1-1.30.6-1.0-0.7-0.9-0.71.2-0.81.2
Compulsive drug intake0.40.61.2-0.80.81.01.1-0.50.80.60.70.6-1.00.6-0.9
One hour access (shock baseline)1.33.45.01.8-1.8-2.1-2.21.4-1.9-1.5-1.7-1.62.2-1.62.1
Social response proportion0.00.00.1-0.20.20.00.1-0.10.10.10.10.1-0.20.3-0.0
Social responses0.00.00.1-0.10.10.10.30.10.1-0.00.1-0.1-0.20.1-0.1
Social time0.00.00.10.1-0.10.20.30.30.0-0.2-0.1-0.2-0.2-0.1-0.2
Soleus weight3.19.210.12.9-2.9-3.0-3.03.0-3.1-3.1-3.0-3.03.0-3.03.2
Bone: stiffness0.30.50.8-0.90.90.60.5-0.80.60.80.70.7-0.40.7-0.4
Tibialis anterior weight9.833.635.1-5.85.85.95.9-5.75.85.75.85.7-5.95.7-5.9
Time to tail flick, vehicle, before self-admin0.10.20.3-0.30.30.30.2-0.50.40.50.40.6-0.40.5-0.4
Time to tail flick, vehicle, after self-admin0.30.50.8-0.50.50.70.6-0.90.80.90.70.9-0.70.8-0.9
Time to tail flick, test, before self-admin0.20.30.6-0.30.40.20.3-0.50.50.60.50.6-0.70.6-0.6
Time to tail flick, test, after self-admin0.00.00.1-0.20.2-0.0-0.00.0-0.0-0.10.0-0.10.1-0.10.3
Delta time to tail flick, vehicle, before/after SA0.30.30.5-0.50.50.60.6-0.50.60.50.50.6-0.50.5-0.7
Delta time to tail flick, test, before/after SA0.00.10.1-0.20.20.20.10.1-0.1-0.3-0.1-0.30.4-0.30.3
Tibia length1.43.95.1-2.32.31.91.8-2.11.92.02.01.9-1.62.0-1.7
Ambulatory time before self-admin0.61.72.9-1.71.71.21.1-1.51.21.41.31.3-0.91.3-0.9
Ambulatory time after self-admin0.10.10.2-0.30.30.30.2-0.40.30.40.30.4-0.00.3-0.1
Bone: tissue strength0.70.80.80.8-0.8-0.9-0.90.9-0.9-0.9-0.9-0.90.9-0.90.9
Total heroin consumption6.07.18.9-2.82.82.93.0-2.42.72.52.72.4-2.72.5-2.7
Bone: trabecular number0.71.31.7-1.21.21.01.0-1.31.11.31.11.3-1.11.2-1.1
Bone: trabecular spacing0.50.71.00.8-0.8-0.6-0.61.0-0.8-1.0-0.9-0.90.8-1.00.8
Bone: trabecular thickness0.20.30.50.5-0.5-0.7-0.70.5-0.6-0.5-0.5-0.60.7-0.50.7
Bone: trabecular tissue density4.07.07.62.7-2.7-2.6-2.52.7-2.6-2.7-2.6-2.82.6-2.72.6
Water consumed over 24 hours0.30.50.7-0.80.80.80.8-0.70.70.70.60.6-0.70.7-0.8
Number of responses in last shaping day0.50.61.2-0.40.40.91.0-0.70.90.70.80.8-0.70.8-1.1