Hub : Genes

Fth1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Fth1 0.34 0.12 0.0e+00 0.45 0.44 0.44 0.44 2.0e-46 1.7e-44 1.2e-44 5.0e-45
2 BLA gene expression Fth1 0.33 0.13 0.0e+00 0.35 0.35 0.34 0.35 3.3e-19 3.6e-19 6.6e-19 2.3e-19
3 pVTA gene expression Fth1 0.1 0.06 2.1e-10 0.12 0.13 0.11 0.12 5.5e-10 1.9e-10 3.4e-09 3.0e-10
4 IC gene expression Fth1 0.26 0.12 5.4e-11 0.18 0.18 0.15 0.18 4.7e-08 4.4e-08 7.8e-07 5.0e-08
5 Liver mRNA stability Fth1 0.1 0.05 7.8e-12 0.08 0.08 0.07 0.08 2.8e-09 2.3e-09 1.0e-08 7.0e-09
6 LHb gene expression Fth1 0.14 0.11 8.1e-03 0.04 0.04 0.02 0.04 4.6e-02 3.8e-02 9.8e-02 4.9e-02
7 Liver gene expression Fth1 0.07 0.04 2.0e-08 0.05 0.06 0.05 0.05 4.8e-06 5.6e-07 5.7e-06 1.3e-06
8 PL gene expression Fth1 0.38 0.19 0.0e+00 0.37 0.4 0.39 0.39 4.3e-42 3.2e-46 1.4e-45 2.9e-45
9 OFC gene expression Fth1 0.35 0.19 3.0e-05 0.08 0.14 0.1 0.13 5.0e-03 2.8e-04 2.3e-03 5.4e-04
10 NAcc gene expression Fth1 0.15 0.07 0.0e+00 0.24 0.24 0.24 0.24 2.0e-36 7.9e-36 2.6e-36 2.6e-35
11 IL gene expression Fth1 0.53 0.17 8.4e-11 0.22 0.34 0.3 0.29 6.1e-06 7.3e-09 6.7e-08 9.3e-08
12 Brain mRNA stability Fth1 0.07 0.05 2.4e-06 0.06 0.06 0.06 0.06 1.1e-06 6.1e-06 1.5e-06 2.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.30.50.60.60.40.4-0.70.60.70.60.70.50.70.5
Area under the delay curve0.10.20.30.20.20.20.3-0.40.40.50.50.40.50.60.5
BMI with tail2.68.912.22.82.82.72.4-3.43.03.32.83.52.93.13.0
BMI without tail0.72.23.11.11.11.41.3-1.51.51.51.31.71.81.51.7
Body weight3.716.018.63.83.83.83.6-4.24.04.23.94.34.04.24.2
Weight adjusted by age0.71.11.61.11.01.21.1-1.21.11.10.81.20.60.91.1
Bone surface1.73.13.81.91.91.61.5-2.01.71.91.91.81.51.91.6
Bone volume0.61.01.41.21.20.80.7-1.20.91.21.11.10.71.10.8
Breakpoint value in progressive ratio session2.42.93.71.71.71.91.9-1.61.81.61.71.61.61.61.7
Number of licking bursts0.00.00.0-0.0-0.0-0.00.00.00.00.00.1-0.00.1-0.00.0
Context. condit. distance diff. score0.10.10.2-0.5-0.5-0.2-0.30.2-0.3-0.2-0.5-0.2-0.3-0.3-0.2
Locomotion velocity, session 10.00.00.10.10.10.30.2-0.20.20.10.10.30.20.20.2
Locomotion distance, session 10.81.11.40.90.91.11.0-1.11.01.00.91.21.01.01.1
Locomotion velocity, session 23.33.94.12.02.01.91.9-2.02.02.02.02.01.92.01.9
Locomotion distance, session 20.50.71.00.60.60.90.9-0.80.90.80.80.91.00.81.0
Locomotion velocity, session 30.40.50.80.50.50.50.4-0.80.60.90.50.90.70.80.7
Locomotion distance, session 30.00.00.00.20.2-0.00.0-0.10.10.10.10.10.10.20.1
Stereotopy head waving bouts, day 30.00.10.2-0.2-0.2-0.0-0.1-0.20.10.20.10.40.40.20.4
Stereotopy head waving duration, day 30.10.10.3-0.1-0.10.20.2-0.30.30.30.20.40.50.30.5
Locomotion velocity, session 70.00.00.10.20.20.10.1-0.20.20.30.30.20.30.30.2
Locomotion distance, session 70.00.00.1-0.2-0.2-0.1-0.00.00.00.1-0.00.10.20.10.2
Stereotopy head waving bouts, day 70.20.20.30.50.50.40.4-0.60.50.50.50.50.30.50.4
Stereotopy head waving duration, day 71.62.02.21.41.41.41.4-1.51.41.41.51.41.31.51.4
Locomotion velocity, session 80.00.00.10.00.00.20.30.00.20.10.10.00.40.20.4
Locomotion distance, session 80.10.10.2-0.5-0.5-0.2-0.30.2-0.2-0.2-0.3-0.1-0.2-0.2-0.1
Degree of sensitization distance0.00.00.2-0.1-0.10.10.0-0.30.20.30.10.40.20.10.3
Degree of sensitization stereotypy1.01.11.41.21.21.11.0-1.21.01.11.11.10.81.00.9
Conditioned locomotion0.60.71.00.80.80.80.9-0.80.90.80.90.81.00.90.9
Cocaine response after cond. corrected0.30.40.5-0.7-0.7-0.5-0.60.6-0.6-0.6-0.7-0.4-0.4-0.7-0.5
Cocaine response after cond. not corrected0.30.40.5-0.6-0.6-0.5-0.70.5-0.6-0.6-0.7-0.4-0.6-0.7-0.7
Cocaine response before conditioning0.10.20.60.80.80.30.2-0.50.20.30.40.2-0.30.3-0.2
Saline control response3.04.04.62.12.12.02.1-1.92.01.92.01.92.02.02.0
Bone: connectivity density1.62.52.91.61.61.51.4-1.71.61.71.61.71.51.71.5
Bone: cortical apparent density0.30.40.50.70.70.70.7-0.50.60.50.60.50.50.50.6
Bone: cortical area0.61.01.51.21.20.90.8-1.00.91.01.00.90.81.00.8
Bone: cortical porosity0.00.00.10.00.00.30.40.10.2-0.00.1-0.10.20.00.2
Bone: cortical porosity0.10.20.40.30.30.50.6-0.20.40.30.40.20.50.30.5
Bone: cortical thickness3.04.95.92.42.42.32.4-2.02.22.02.31.92.22.22.2
Bone: cortical thickness0.30.30.40.70.70.60.7-0.40.50.40.50.40.60.50.6
Bone: cortical tissue density0.40.60.90.80.80.90.9-0.70.80.70.70.60.70.70.7
Condit. Reinf. active minus inactive responses1.01.11.41.21.21.11.0-1.11.01.00.91.10.90.90.9
Condit. Reinf. active-inactive response ratio0.40.40.70.70.70.80.7-0.60.60.50.50.60.60.50.6
Condit. Reinf. active responses0.81.01.41.21.21.00.8-1.21.01.00.81.20.80.90.7
Condit. Reinf. inactive responses0.00.00.2-0.0-0.0-0.2-0.4-0.1-0.20.0-0.30.1-0.3-0.1-0.4
Incentive salience index mean1.11.31.71.31.31.10.9-1.31.11.21.01.31.01.10.9
Condit. Reinf. lever presses0.60.81.31.11.10.70.6-1.10.81.00.91.00.71.00.7
Condit. Reinf. active minus inactive responses0.10.20.5-0.2-0.2-0.3-0.40.3-0.4-0.4-0.3-0.4-0.6-0.5-0.7
Condit. Reinf. active-inactive response ratio0.30.30.7-0.5-0.5-0.6-0.70.3-0.6-0.4-0.5-0.4-0.8-0.6-0.8
Condit. Reinf. active responses0.00.10.20.40.40.20.1-0.30.20.20.20.2-0.00.2-0.1
Condit. Reinf. inactive responses0.10.10.20.50.50.30.3-0.20.20.20.20.20.20.30.2
Condit. Reinf. lever presses0.60.81.31.11.10.80.7-1.10.91.00.91.00.60.90.5
Condit. Reinf. lever reinforcers received0.10.20.40.60.60.50.4-0.50.40.40.40.40.20.30.1
Conditioned reinforcement - actives0.20.30.7-0.5-0.5-0.4-0.50.4-0.5-0.5-0.6-0.5-0.8-0.6-0.8
Conditioned reinforcement - inactives0.00.10.3-0.2-0.2-0.2-0.4-0.1-0.20.0-0.20.0-0.6-0.2-0.4
Conditioned locomotion1.52.02.6-1.6-1.6-1.5-1.61.1-1.4-1.1-1.4-1.1-1.6-1.2-1.4
Patch foraging indifference point 0 sec0.40.81.10.80.80.90.9-0.90.90.91.00.91.00.90.9
Patch foraging indifference point AUC1.11.52.01.41.41.31.3-1.21.21.21.41.10.91.21.0
Delay disc. indifference point, 0s delay0.10.10.4-0.6-0.6-0.4-0.50.1-0.2-0.1-0.30.0-0.2-0.1-0.0
Delay disc. indifference point, 16s delay0.10.10.10.40.40.20.2-0.40.30.40.40.30.20.30.2
Delay disc. indifference point, 2s delay0.10.20.4-0.4-0.4-0.6-0.70.2-0.4-0.2-0.2-0.2-0.5-0.2-0.4
Delay disc. indifference point, 24s delay0.10.10.30.20.20.20.3-0.30.30.40.40.40.50.50.4
Delay disc. indifference point, 4s delay0.60.71.30.50.50.50.7-0.70.80.90.90.81.11.01.0
Delay disc. indifference point, 8s delay0.10.10.4-0.6-0.6-0.4-0.20.4-0.3-0.3-0.1-0.4-0.1-0.2-0.0
Indifference point function ln k2.64.65.7-2.3-2.3-2.2-2.32.1-2.2-2.0-2.4-1.9-1.9-2.1-2.0
Indifference point function log k2.64.65.7-2.3-2.3-2.2-2.32.1-2.2-2.0-2.4-1.9-1.9-2.1-2.0
Patch foraging total patch changes 0 sec0.40.81.20.80.80.91.0-0.80.90.80.90.81.10.91.0
Patch foraging total patch changes 12 sec6.58.59.82.92.93.13.1-2.83.02.83.02.72.92.92.9
Patch foraging total patch changes 18 sec0.50.70.90.90.90.91.0-0.80.90.81.00.80.70.90.8
Patch foraging total patch changes 24 sec4.88.38.82.82.82.92.9-2.92.92.93.02.92.93.02.9
Patch foraging total patch changes 6 sec1.11.61.81.31.31.21.3-1.31.31.31.31.21.41.31.3
Patch foraging time to switch 0 sec0.30.50.70.80.80.60.5-0.90.70.80.70.80.60.80.5
Patch foraging water rate 0 sec0.51.01.2-1.0-1.0-0.9-0.91.1-1.0-1.1-1.0-1.1-0.9-1.0-1.0
Patch foraging water rate 12 sec1.42.93.7-1.9-1.9-1.7-1.61.8-1.7-1.7-1.8-1.6-1.5-1.7-1.5
Patch foraging water rate 18 sec0.40.71.0-1.0-1.0-0.9-0.80.8-0.8-0.8-0.9-0.7-0.5-0.7-0.6
Patch foraging water rate 24 sec1.41.92.4-1.3-1.3-1.4-1.31.5-1.4-1.5-1.6-1.4-1.1-1.5-1.3
Patch foraging water rate 6 sec1.21.82.3-1.5-1.5-1.3-1.21.4-1.3-1.4-1.4-1.4-1.2-1.3-1.0
Seeking ratio, delayed vs. immediate footshock0.00.00.10.10.10.10.1-0.30.20.30.20.30.20.20.1
Distance traveled before self-admin1.72.23.21.81.81.41.3-1.71.41.61.51.51.21.51.2
Distance traveled after self-admin0.30.40.50.60.60.70.7-0.60.60.60.60.60.50.60.5
Extensor digitorum longus weight6.525.526.75.05.05.04.9-5.15.15.15.05.25.15.15.0
Bone: elastic displacement0.30.30.6-0.6-0.6-0.4-0.30.8-0.5-0.7-0.6-0.7-0.4-0.6-0.4
Bone: elastic work1.01.21.71.11.11.21.3-0.91.10.91.11.01.31.11.2
Bone: endosteal estimation1.02.23.7-1.5-1.5-1.8-1.91.1-1.5-1.1-1.6-1.1-1.6-1.3-1.6
Bone: endosteal perimeter1.83.85.9-1.9-1.9-2.2-2.41.5-2.0-1.5-1.9-1.6-2.2-1.7-2.2
Epididymis fat weight0.72.54.1-1.5-1.5-1.9-2.01.2-1.6-1.3-1.5-1.3-1.8-1.5-1.7
Delta time in closed arm before/after self-admin2.22.13.50.91.01.51.6-1.21.51.41.41.41.71.41.9
Delta time in open arm before/after self-admin1.61.62.71.61.61.31.2-1.41.21.31.21.20.91.10.9
Diff in mean of infusions in LGA sessions2.73.34.01.71.71.92.0-1.71.91.71.91.71.91.81.9
Delay discount exponential model param0.20.20.4-0.2-0.2-0.2-0.30.4-0.4-0.5-0.6-0.5-0.5-0.6-0.5
Extinction: sum of active levers before priming3.64.04.22.02.02.02.0-2.02.02.02.12.01.92.02.0
Active lever presses in extinction session 62.52.53.81.91.91.61.5-1.61.51.51.61.41.31.41.2
Bone: final force1.32.02.61.61.61.31.2-1.51.41.51.31.51.31.51.2
Bone: final moment1.32.12.71.61.61.41.3-1.51.41.51.41.51.31.51.3
Food consumed during 24 hour testing period0.30.40.5-0.4-0.4-0.6-0.60.6-0.6-0.7-0.7-0.7-0.7-0.6-0.7
Glucose2.43.84.9-2.2-2.2-2.1-2.21.8-2.0-1.8-1.9-1.6-1.8-1.8-1.9
Heart weight0.10.20.6-0.7-0.7-0.6-0.60.3-0.4-0.2-0.4-0.10.0-0.2-0.0
Delay discount hyperbolic model param0.10.10.2-0.1-0.1-0.1-0.20.3-0.3-0.4-0.5-0.4-0.4-0.5-0.4
Intermittent access intake day 1-15 change1.12.33.6-1.5-1.5-1.5-1.51.3-1.5-1.4-1.5-1.5-1.9-1.5-1.7
Intermittent access intake escalation1.42.94.4-1.7-1.7-1.6-1.71.5-1.7-1.6-1.7-1.6-2.1-1.7-1.9
Intermittent access intake escalation 20.70.81.6-0.8-0.8-0.8-0.90.6-0.8-0.8-0.8-0.8-1.3-0.8-1.1
Intermitt. access day 1 inactive lever presses0.31.01.8-1.0-1.0-0.9-1.00.8-1.0-0.9-1.1-0.9-1.3-1.0-1.0
Intermitt. access day 15 inactive lever presses0.40.81.80.90.90.70.4-1.30.91.20.91.20.31.00.6
Intermitt. access escalation Index0.50.71.2-1.1-1.1-0.9-0.80.9-0.8-0.8-0.7-0.9-0.8-0.8-0.7
Intermittent access day 1 total infusions0.10.20.7-0.6-0.6-0.6-0.8-0.2-0.30.1-0.40.2-0.5-0.1-0.4
Intermittent access day 15 total infusions2.84.15.7-2.3-2.3-2.1-2.41.5-2.0-1.6-2.0-1.6-2.4-1.8-2.2
Intermittent access terminal intake (last 3 days)0.81.01.9-1.2-1.2-1.1-1.40.4-0.9-0.5-0.9-0.5-1.4-0.8-1.2
Intermittent access total infusions0.70.91.8-1.2-1.2-1.1-1.30.4-0.9-0.5-0.9-0.4-1.1-0.7-1.0
Intermittent access day 1 locomotion0.00.10.2-0.1-0.1-0.1-0.3-0.40.10.4-0.00.5-0.10.20.1
Intermittent access day 15 total locomotion0.10.10.5-0.3-0.3-0.3-0.6-0.4-0.20.2-0.30.3-0.7-0.0-0.3
Intermittent access total locomotion0.20.20.8-0.3-0.3-0.5-0.9-0.5-0.30.3-0.30.4-0.7-0.0-0.5
Intermittent access standard deviation0.51.01.5-1.2-1.2-0.8-0.90.8-0.9-0.9-1.0-0.8-1.2-1.0-0.9
Left kidney weight0.10.41.0-0.6-0.6-0.9-1.00.3-0.6-0.3-0.5-0.3-0.6-0.3-0.6
Right kidney weight0.00.20.5-0.5-0.5-0.7-0.70.3-0.5-0.3-0.3-0.3-0.4-0.3-0.4
Cocaine induced anxiety0.00.10.20.40.40.30.2-0.20.20.10.10.10.00.10.0
Post-drug Anxiety0.30.30.60.80.80.50.5-0.60.50.60.50.60.40.50.4
Baseline Anxiety0.30.40.60.50.50.50.5-0.60.60.70.60.70.80.70.8
Tail length0.31.22.00.90.91.21.3-0.81.10.91.10.81.31.11.4
Length with tail1.35.86.82.32.32.42.4-2.42.42.42.42.32.32.52.6
Length without tail2.99.410.13.03.03.03.0-3.13.13.13.13.13.03.13.2
Times rat made contact with spout0.10.20.30.40.40.50.6-0.20.40.30.30.30.50.30.5
Lifetime Intake0.50.61.3-1.1-1.1-0.9-1.10.3-0.7-0.4-0.7-0.3-0.9-0.5-0.7
Liver weight, left1.11.92.2-1.5-1.5-1.3-1.31.4-1.3-1.4-1.4-1.3-1.3-1.4-1.2
Liver weight, right1.52.53.1-1.8-1.8-1.7-1.71.5-1.6-1.5-1.6-1.4-1.5-1.5-1.5
Locomotor activity0.50.81.3-1.1-1.1-0.8-0.61.1-0.8-1.0-0.7-1.0-0.6-0.8-0.4
Locomotor testing distance0.50.91.3-1.1-1.1-0.9-0.91.1-0.9-1.1-0.8-0.9-0.8-0.9-0.6
Locomotor testing rearing0.71.41.6-1.2-1.2-1.1-1.11.2-1.2-1.3-1.2-1.2-1.2-1.2-1.1
Locomotion in novel chamber1.72.12.8-1.5-1.5-1.5-1.61.2-1.5-1.3-1.3-1.3-1.7-1.3-1.5
Locomotion in novel chamber post-restriction1.52.53.0-1.7-1.7-1.5-1.41.6-1.5-1.6-1.5-1.6-1.4-1.6-1.5
Fecal boli incidents, locomotor time 10.30.41.0-0.4-0.4-0.5-0.60.4-0.6-0.6-0.6-0.6-1.0-0.7-1.0
Change in fecal boli incidents, locomotor task0.90.91.3-1.1-1.1-1.1-1.11.0-1.0-0.9-1.0-0.8-0.5-0.7-0.4
Time >=10cm from walls, locomotor time 12.12.33.4-1.4-1.4-1.5-1.71.2-1.5-1.3-1.6-1.3-1.8-1.6-1.6
Bouts of movement, locomotor time 10.30.30.80.60.60.80.9-0.30.60.30.50.20.30.20.6
Total resting periods, locomotor time 10.20.20.60.60.60.70.8-0.30.50.30.50.20.20.20.5
Rest time, locomotor task time 11.82.22.4-1.5-1.5-1.5-1.41.5-1.5-1.5-1.4-1.6-1.5-1.6-1.4
Distance moved, locomotor task time 10.20.40.50.60.60.60.5-0.70.60.70.50.70.50.70.3
Vertical activity count, locomotor time 10.20.50.6-0.7-0.7-0.7-0.70.7-0.7-0.7-0.7-0.7-0.8-0.6-0.8
Time >=10cm from walls, locomotor time 20.20.30.9-0.1-0.1-0.4-0.50.4-0.5-0.5-0.5-0.6-0.6-0.6-1.0
Bouts of movement, locomotor time 20.91.42.01.21.21.41.3-1.21.21.11.01.21.10.91.2
Total resting periods, locomotor time 20.40.71.10.80.81.00.9-0.80.80.70.60.90.70.50.9
Rest time, locomotor task time 22.63.34.4-2.1-2.1-1.7-1.71.8-1.8-1.8-1.8-1.7-1.8-1.9-1.5
Distance moved, locomotor task time 20.40.50.80.90.90.70.7-0.60.70.60.70.50.70.70.3
Vertical activity count, locomotor time 20.00.00.1-0.0-0.0-0.10.10.4-0.1-0.3-0.0-0.40.1-0.1-0.1
Light reinforcement 10.10.20.4-0.2-0.2-0.4-0.40.3-0.4-0.4-0.3-0.4-0.5-0.4-0.6
Light reinforcement 20.20.40.8-0.3-0.3-0.8-0.90.3-0.6-0.4-0.5-0.5-0.8-0.5-0.9
Bone: marrow area1.22.74.2-1.7-1.7-1.9-2.11.3-1.7-1.3-1.7-1.3-1.7-1.4-1.7
Bone: maximum diameter0.10.10.30.50.50.10.0-0.50.20.50.30.40.10.40.1
Bone: maximum force1.93.44.42.02.01.71.5-2.11.82.01.82.01.62.01.6
Bone: maximum moment2.03.54.32.02.01.71.6-2.11.82.01.82.01.62.01.6
Mean time between licks in bursts0.10.30.80.40.40.60.7-0.40.60.50.40.60.90.50.8
Mean num. licks in bursts0.00.00.1-0.1-0.10.10.10.2-0.1-0.2-0.2-0.2-0.0-0.2-0.0
Cd content in liver0.70.81.0-0.8-0.8-0.9-0.90.8-0.9-0.9-0.8-0.8-1.0-0.8-1.0
Co content in liver0.70.81.1-0.9-0.9-0.8-0.61.1-0.9-1.0-0.9-1.0-0.8-1.0-0.8
Cu content in liver0.00.00.0-0.1-0.1-0.00.10.1-0.0-0.1-0.1-0.10.10.00.1
Fe content in liver0.00.00.0-0.1-0.1-0.0-0.10.0-0.0-0.0-0.10.00.0-0.00.0
K content in liver0.30.30.40.60.60.40.4-0.70.50.60.60.60.40.60.4
Mg content in liver0.00.00.10.10.1-0.0-0.0-0.20.10.20.20.20.20.20.2
Mn content in liver3.03.33.61.91.91.81.8-1.81.81.81.91.81.71.81.7
Na content in liver0.20.20.50.70.70.40.3-0.60.40.40.40.50.20.40.2
Rb content in liver2.63.03.3-1.8-1.8-1.8-1.71.8-1.7-1.8-1.8-1.7-1.5-1.7-1.7
Se content in liver0.10.10.10.20.20.20.2-0.40.30.40.30.30.10.20.2
Sr content in liver5.24.55.02.12.12.22.2-2.12.22.12.12.12.12.12.2
Zn content in liver3.53.84.21.91.92.02.0-1.92.01.92.02.02.02.02.0
Bone: minimum diameter0.61.12.1-1.0-1.0-1.3-1.50.7-1.1-0.8-1.0-0.8-1.3-0.9-1.2
Time in familiar zone, hab. session 10.00.00.00.20.20.10.0-0.20.10.10.00.1-0.10.1-0.1
Time in novel zone, hab. session 11.51.51.6-1.3-1.3-1.2-1.21.3-1.2-1.3-1.2-1.2-1.1-1.2-1.1
Total zone transitions, hab. session 10.30.40.60.50.50.70.8-0.60.70.60.70.60.70.60.8
Total locomotion distance, hab. session 10.00.00.0-0.1-0.1-0.0-0.1-0.1-0.00.1-0.00.1-0.0-0.0-0.0
Locomotion velocity, hab. session 10.20.30.50.50.50.60.5-0.60.60.60.60.70.60.60.6
Time in familiar zone, hab. session 20.70.81.0-0.7-0.7-0.8-0.80.9-0.9-0.9-0.8-1.0-1.0-0.9-0.9
Time in novel zone, hab. session 20.80.81.10.80.80.90.8-1.00.91.00.91.01.01.01.0
Total zone transitions, hab. session 21.21.51.71.31.31.21.2-1.21.21.21.31.21.21.31.2
Total locomotion distance, hab. session 20.10.20.30.40.40.40.3-0.50.40.40.40.50.40.40.4
Locomotion velocity, hab. session 20.10.10.10.30.30.20.1-0.30.20.30.20.40.30.30.2
Novel to familiar place preference ratio2.42.63.11.51.51.51.6-1.61.61.61.61.61.71.71.8
Novelty place preference1.51.61.91.11.11.21.2-1.21.31.31.21.31.41.31.4
Time in novel zone, NPP test1.61.72.21.11.11.31.3-1.31.31.41.31.41.41.41.5
Total zone transitions, NPP test1.42.02.31.41.41.51.5-1.31.41.31.51.31.41.41.5
Total locomotion distance, NPP test0.20.30.40.40.40.50.5-0.40.50.50.50.50.60.50.6
Locomotion velocity, NPP test0.10.20.30.30.30.40.4-0.30.40.30.50.30.50.40.5
Intraocular pressure0.10.20.3-0.4-0.4-0.3-0.30.5-0.4-0.5-0.5-0.5-0.5-0.6-0.4
Delta distance traveled before/after self-admin0.50.50.9-0.9-0.9-0.5-0.40.9-0.6-0.8-0.7-0.7-0.4-0.7-0.4
Delta ambulatory time before/after self-admin0.60.81.4-1.2-1.2-0.7-0.61.1-0.8-1.0-0.9-0.9-0.6-0.9-0.6
Parametrial fat weight1.33.25.0-1.9-1.9-2.2-2.21.5-1.8-1.4-1.6-1.5-1.9-1.5-1.8
Pavlov. Cond. lever latency0.70.91.2-1.1-1.1-0.9-0.81.1-0.9-1.0-1.0-1.0-0.8-1.1-0.8
Pavlov. Cond. magazine entry latency0.70.91.41.11.10.90.7-1.20.91.10.91.00.60.90.6
Pavlov. Cond. change in total contacts0.20.30.50.70.70.50.3-0.70.50.50.50.50.20.50.2
Pavlov. Cond. index score0.50.60.90.90.90.70.6-0.90.70.80.80.80.50.80.5
Pavlov. Cond. latency score0.40.50.70.90.90.60.5-0.80.60.70.70.70.40.70.5
Pavlov. Cond. lever contacts0.30.30.50.70.70.50.4-0.70.50.60.60.60.40.70.4
Pavlov. Cond. magazine entry number0.60.81.2-1.1-1.1-0.9-0.81.0-0.9-0.9-0.9-0.8-0.6-0.8-0.6
Pavlov. Cond. intertrial magazine entries0.10.10.10.40.40.30.3-0.10.20.10.40.10.20.20.2
Pavlov. Cond. lever-magazine prob. diff.0.50.70.91.01.00.80.7-0.90.80.80.80.80.50.80.6
Pavlov. Cond. response bias0.70.91.31.11.10.90.8-1.10.91.00.90.90.60.90.7
Pavlov. Cond. lever latency0.30.50.9-0.9-0.9-0.7-0.50.9-0.7-0.8-0.6-0.8-0.3-0.6-0.3
Pavlov. Cond. magazine entry latency5.16.17.82.82.82.62.4-2.72.52.52.32.62.02.32.0
Pavlov. Cond. change in total contacts0.81.32.31.51.51.20.9-1.41.11.21.01.20.51.00.5
Pavlov. Cond. index score2.33.14.42.12.11.81.5-2.11.71.91.61.91.21.61.2
Pavlov. Cond. latency score2.22.94.22.02.01.71.5-2.01.71.81.61.91.11.61.2
Pavlov. Cond. lever contacts0.30.40.70.80.80.60.4-0.80.60.70.40.70.20.40.2
Pavlov. Cond. magazine entry number7.69.411.8-3.4-3.4-3.2-2.93.3-3.1-3.1-2.9-3.2-2.5-2.9-2.6
Pavlov. Cond. intertrial magazine entries1.42.02.3-1.5-1.5-1.5-1.41.5-1.4-1.5-1.3-1.5-1.4-1.4-1.3
Pavlov. Cond. lever-magazine prob. diff.2.63.55.02.22.22.01.6-2.21.92.01.72.01.31.71.3
Pavlov. Cond. response bias1.62.23.11.81.81.51.3-1.81.51.61.41.61.11.41.1
Time in closed arm before self-admin0.10.20.5-0.3-0.3-0.5-0.50.1-0.4-0.2-0.3-0.3-0.7-0.3-0.5
Time in closed arm after self-admin0.60.71.3-1.1-1.1-0.8-0.70.8-0.7-0.7-0.7-0.7-0.8-0.7-0.6
Time in open arm before self-admin0.60.61.2-1.1-1.1-0.8-0.61.1-0.8-0.9-0.8-0.8-0.2-0.7-0.2
Time in open arm after self-admin0.50.50.90.90.90.70.8-0.50.70.50.70.50.90.60.9
Bone: periosteal estimation0.10.10.4-0.1-0.1-0.5-0.6-0.0-0.3-0.0-0.3-0.1-0.5-0.1-0.5
Bone: periosteal perimeter0.00.10.3-0.0-0.0-0.4-0.5-0.0-0.3-0.1-0.2-0.1-0.5-0.1-0.4
Bone: post-yield work0.20.20.8-0.3-0.3-0.7-0.9-0.0-0.4-0.0-0.3-0.1-0.7-0.1-0.7
Progressive ratio test 1 active lever presses0.10.20.4-0.6-0.6-0.4-0.50.2-0.3-0.2-0.4-0.2-0.5-0.3-0.3
Progressive ratio test 1 breakpoint0.10.20.3-0.6-0.6-0.4-0.50.2-0.3-0.2-0.4-0.2-0.5-0.3-0.4
Progressive ratio test 1 inactive lever presses0.91.32.00.80.81.10.9-1.41.21.31.11.41.01.21.2
Progressive ratio test 2 active lever presses0.60.71.3-1.0-1.0-0.9-1.10.4-0.8-0.5-0.8-0.5-1.0-0.7-1.0
Progressive ratio test 2 breakpoint0.60.71.2-1.0-1.0-0.9-1.10.4-0.8-0.5-0.8-0.5-1.0-0.6-1.0
Progressive ratio test 2 inactive lever presses0.20.40.9-0.6-0.6-0.7-0.90.1-0.6-0.3-0.6-0.2-0.9-0.4-0.8
Incentive Sensitization - Responses0.30.50.90.70.70.50.3-1.00.60.90.60.90.60.70.3
Incentive Sensitization - Breakpoint0.30.30.80.60.60.40.2-0.90.50.80.50.80.40.60.2
Sum of active levers in priming session hrs 5-60.60.51.11.11.10.80.8-0.70.70.60.80.50.40.60.3
Progressive ratio0.00.00.1-0.1-0.1-0.2-0.4-0.1-0.10.1-0.10.1-0.3-0.0-0.3
Food seeking constrained by brief footshock0.00.00.1-0.3-0.3-0.2-0.20.2-0.2-0.2-0.3-0.1-0.1-0.2-0.2
Seeking ratio, punishment vs. effort0.00.10.3-0.1-0.10.20.20.10.1-0.00.00.10.50.10.4
Retroperitoneal fat weight3.314.117.3-4.2-4.2-4.1-4.13.5-3.8-3.4-3.6-3.5-3.8-3.5-3.5
Reaction time number correct0.10.30.40.60.60.60.6-0.50.50.40.50.50.50.50.6
Reaction time mean minus median0.20.50.70.80.80.80.8-0.70.70.60.70.60.50.50.5
Reaction time mean minus median AUC0.00.10.30.40.40.50.5-0.20.30.10.20.10.20.10.2
Reaction time num false alarms0.10.20.3-0.5-0.5-0.3-0.20.6-0.3-0.5-0.3-0.5-0.0-0.3-0.1
Reaction time num false alarms AUC0.10.10.4-0.0-0.00.30.50.10.20.00.30.00.60.20.6
Reaction time trials correct on left0.10.30.40.60.60.60.6-0.50.50.40.50.50.50.50.6
Reaction time trials on left0.20.30.40.60.60.60.6-0.50.50.50.50.50.60.60.7
Reaction time mean0.00.10.40.00.00.0-0.10.0-0.1-0.2-0.2-0.1-0.7-0.3-0.3
Reaction time mean AUC0.10.20.9-0.2-0.2-0.2-0.40.2-0.4-0.4-0.5-0.4-0.9-0.6-0.6
Median of all reaction times0.00.10.50.10.10.0-0.1-0.1-0.1-0.1-0.2-0.0-0.7-0.2-0.3
Reaction time omissions0.30.40.60.80.80.70.8-0.50.60.50.60.40.60.50.5
Reaction time false alarm rate0.00.10.2-0.4-0.4-0.2-0.10.4-0.2-0.3-0.1-0.30.1-0.10.1
Reaction time premature initiation rate4.25.96.72.32.32.22.2-2.52.42.62.32.62.52.62.4
Reaction time premature initiations3.97.07.52.62.62.62.5-2.72.62.72.52.72.72.72.7
Std. dev. reaction times0.00.10.2-0.0-0.00.10.00.2-0.1-0.3-0.2-0.3-0.4-0.3-0.3
Reaction time trials completed0.20.30.40.60.60.60.6-0.50.50.50.50.50.60.60.7
Reaction time trials AUC0.10.20.30.50.50.50.5-0.40.40.40.40.40.50.50.6
Run reversals in cocaine runway, females0.50.50.90.60.60.40.4-0.70.60.80.60.81.00.80.7
Run reversals in cocaine runway, males0.50.50.8-0.7-0.7-0.8-0.60.9-0.7-0.8-0.5-0.9-0.5-0.6-0.5
Latency to leave start box in cocaine runway0.30.40.8-0.7-0.7-0.9-0.90.4-0.6-0.4-0.5-0.4-0.7-0.4-0.6
Latency to leave start box in cocaine runway, F0.00.00.10.20.20.00.0-0.30.20.30.30.30.20.30.2
Latency to leave start box in cocaine runway, M2.52.32.8-1.6-1.6-1.7-1.71.4-1.5-1.4-1.5-1.4-1.5-1.4-1.5
Std. dev. time between licks in bursts0.10.10.2-0.4-0.4-0.4-0.40.5-0.4-0.4-0.4-0.3-0.2-0.3-0.3
Total sessions with >9 infusions0.50.61.3-1.1-1.1-0.7-0.80.5-0.7-0.6-0.8-0.5-0.8-0.7-0.6
Short access day 1 total inactive lever presses0.00.00.0-0.2-0.2-0.1-0.2-0.0-0.00.1-0.00.1-0.00.00.0
Short access day 10 total inactive lever presses0.30.60.8-0.8-0.8-0.6-0.60.9-0.8-0.9-0.9-0.8-0.8-0.9-0.7
Short access day 1 total infusions0.91.22.0-1.4-1.4-1.1-1.21.0-1.1-1.0-1.1-0.9-1.1-1.0-0.9
Short access day 10 total infusions0.10.20.4-0.6-0.6-0.5-0.7-0.1-0.30.0-0.40.1-0.4-0.1-0.4
Short access total infusions0.30.41.0-1.0-1.0-0.6-0.70.2-0.5-0.3-0.6-0.2-0.5-0.4-0.4
Short access day 1 locomotion0.10.20.4-0.7-0.7-0.3-0.40.2-0.3-0.3-0.3-0.3-0.5-0.3-0.2
Short access day 10 total locomotion0.00.10.30.20.20.0-0.2-0.50.10.4-0.10.60.00.2-0.1
Short access total locomotion0.10.10.1-0.3-0.3-0.2-0.4-0.2-0.10.2-0.20.2-0.4-0.0-0.1
One hour access (0.3 mA shock)0.81.01.7-0.9-0.9-1.1-1.30.6-1.0-0.7-0.9-0.7-1.2-0.8-1.2
Compulsive drug intake0.50.61.20.80.81.01.1-0.50.80.60.70.61.00.60.9
One hour access (shock baseline)2.23.45.0-1.8-1.8-2.1-2.21.4-1.9-1.5-1.7-1.6-2.2-1.6-2.1
Social response proportion0.00.00.10.20.20.00.1-0.10.10.10.10.10.20.30.0
Social responses0.00.00.10.10.10.10.30.10.1-0.00.1-0.10.20.10.1
Social time0.00.00.1-0.1-0.10.20.30.30.0-0.2-0.1-0.20.2-0.10.2
Soleus weight3.19.210.1-2.9-2.9-3.0-3.03.0-3.1-3.1-3.0-3.0-3.0-3.0-3.2
Bone: stiffness0.30.50.80.90.90.60.5-0.80.60.80.70.70.40.70.4
Tibialis anterior weight9.933.635.15.85.85.95.9-5.75.85.75.85.75.95.75.9
Time to tail flick, vehicle, before self-admin0.20.20.30.30.30.30.2-0.50.40.50.40.60.40.50.4
Time to tail flick, vehicle, after self-admin0.40.50.80.50.50.70.6-0.90.80.90.70.90.70.80.9
Time to tail flick, test, before self-admin0.20.30.60.30.40.20.3-0.50.50.60.50.60.70.60.6
Time to tail flick, test, after self-admin0.00.00.10.20.2-0.0-0.00.0-0.0-0.10.0-0.1-0.1-0.1-0.3
Delta time to tail flick, vehicle, before/after SA0.30.30.50.50.50.60.6-0.50.60.50.50.60.50.50.7
Delta time to tail flick, test, before/after SA0.10.10.10.20.20.20.10.1-0.1-0.3-0.1-0.3-0.4-0.3-0.3
Tibia length1.43.95.12.32.31.91.8-2.11.92.02.01.91.62.01.7
Ambulatory time before self-admin1.21.72.91.71.71.21.1-1.51.21.41.31.30.91.30.9
Ambulatory time after self-admin0.10.10.20.30.30.30.2-0.40.30.40.30.40.00.30.1
Bone: tissue strength0.80.80.8-0.8-0.8-0.9-0.90.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9
Total heroin consumption6.07.18.92.82.82.93.0-2.42.72.52.72.42.72.52.7
Bone: trabecular number0.81.31.71.21.21.01.0-1.31.11.31.11.31.11.21.1
Bone: trabecular spacing0.50.71.0-0.8-0.8-0.6-0.61.0-0.8-1.0-0.9-0.9-0.8-1.0-0.8
Bone: trabecular thickness0.30.30.5-0.5-0.5-0.7-0.70.5-0.6-0.5-0.5-0.6-0.7-0.5-0.7
Bone: trabecular tissue density4.87.07.6-2.7-2.7-2.6-2.52.7-2.6-2.7-2.6-2.8-2.6-2.7-2.6
Water consumed over 24 hours0.40.50.70.80.80.80.8-0.70.70.70.60.60.70.70.8
Number of responses in last shaping day0.60.61.20.40.40.91.0-0.70.90.70.80.80.70.81.1