LOC102554746

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC102554746	0.11	0.06	4.8e-10	0.1	0.11	0.11	0.1	3.4e-09	1.1e-10	2.6e-10	6.0e-10
2	NAcc	gene expression	LOC102554746	0.06	0.03	4.8e-09	0.07	0.08	0.07	0.07	2.3e-08	3.9e-09	7.7e-09	4.8e-09
3	pVTA	gene expression	LOC102554746	0.26	0.11	1.2e-09	0.23	0.21	0.21	0.22	2.4e-10	2.6e-09	1.3e-09	5.9e-10
4	BLA	gene expression	LOC102554746	0.15	0.08	1.1e-07	0.13	0.1	0.1	0.11	2.2e-07	4.7e-06	7.6e-06	2.8e-06
5	LHb	gene expression	LOC102554746	0.22	0.11	1.9e-04	0.1	0.07	0.01	0.09	1.9e-03	1.0e-02	1.4e-01	4.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.5	0.7	0.4	-0.6	-0.3	-0.7
Area under the delay curve	3.2	3.3	4.1	-1.8	-1.7	2.0	1.9	1.6
BMI with tail	0.3	0.8	1.2	-1.0	-1.1	0.8	0.9	0.8
BMI without tail	0.0	0.0	0.1	0.2	0.2	-0.1	-0.3	-0.2
Body weight	0.6	2.7	3.3	-1.7	-1.8	1.6	1.7	1.3
Weight adjusted by age	1.9	2.1	2.6	-1.4	-1.5	1.6	1.2	1.4
Bone surface	0.2	0.3	0.4	0.6	0.4	-0.6	-0.3	-0.6
Bone volume	0.1	0.2	0.4	0.6	0.3	-0.5	-0.1	-0.6
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.0	-0.1	-0.3	-0.2	-0.1
Number of licking bursts	0.2	0.2	0.3	-0.4	-0.5	0.6	0.5	0.4
Context. condit. distance diff. score	0.4	0.5	1.0	0.7	0.7	-0.8	-0.2	-1.0
Locomotion velocity, session 1	1.6	1.8	2.6	-1.5	-1.4	1.0	1.0	1.6
Locomotion distance, session 1	1.1	1.5	1.8	-1.3	-1.3	0.9	1.2	1.3
Locomotion velocity, session 2	0.3	0.4	0.9	-0.4	-0.7	0.6	1.0	0.0
Locomotion distance, session 2	0.1	0.1	0.4	-0.1	-0.5	0.3	0.6	0.0
Locomotion velocity, session 3	0.9	1.1	1.9	-0.9	-1.2	1.1	1.4	0.5
Locomotion distance, session 3	1.4	1.5	2.9	-1.0	-1.3	1.2	1.7	0.9
Stereotopy head waving bouts, day 3	1.0	1.2	1.5	1.2	1.1	-0.6	-1.2	-1.2
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.4	-0.3	0.5	0.1	0.4
Locomotion velocity, session 7	0.2	0.2	0.4	0.5	0.1	-0.3	0.5	-0.7
Locomotion distance, session 7	1.9	2.4	3.3	1.8	1.5	-1.5	-0.9	-1.8
Stereotopy head waving bouts, day 7	3.5	3.9	5.1	-1.9	-2.0	2.3	1.7	1.9
Stereotopy head waving duration, day 7	4.8	5.8	6.6	-2.4	-2.5	2.6	2.2	2.3
Locomotion velocity, session 8	0.3	0.4	1.3	-0.3	-0.6	0.3	1.2	-0.1
Locomotion distance, session 8	0.1	0.1	0.5	-0.0	-0.2	-0.1	0.7	-0.3
Degree of sensitization distance	7.7	7.8	8.3	2.9	2.9	-2.8	-2.8	-2.6
Degree of sensitization stereotypy	4.1	4.5	5.0	-2.2	-2.1	2.2	1.8	2.2
Conditioned locomotion	0.8	1.0	1.2	1.1	1.1	-1.1	-0.3	-1.0
Cocaine response after cond. corrected	0.4	0.5	0.9	0.6	0.6	-1.0	-0.5	-0.5
Cocaine response after cond. not corrected	0.3	0.3	0.5	0.6	0.6	-0.7	-0.4	-0.3
Cocaine response before conditioning	0.7	0.9	1.4	-0.9	-0.8	1.1	0.7	1.2
Saline control response	0.1	0.2	0.5	0.1	0.6	-0.2	-0.7	-0.0
Bone: connectivity density	0.7	1.1	1.4	1.1	1.0	-1.2	-0.8	-1.0
Bone: cortical apparent density	0.7	0.9	1.3	-1.1	-0.9	1.1	0.4	1.0
Bone: cortical area	0.0	0.0	0.0	-0.0	-0.1	0.2	0.1	0.1
Bone: cortical porosity	1.4	1.5	2.2	-1.1	-1.1	1.5	1.4	1.1
Bone: cortical porosity	1.4	1.6	2.3	-1.2	-1.1	1.5	1.3	1.2
Bone: cortical thickness	0.2	0.4	0.5	-0.6	-0.6	0.7	0.3	0.6
Bone: cortical thickness	1.0	1.2	1.4	-1.0	-1.2	1.1	1.2	0.9
Bone: cortical tissue density	0.7	0.9	1.3	-1.1	-0.9	1.0	0.4	1.0
Condit. Reinf. active minus inactive responses	2.2	2.5	3.1	-1.8	-1.6	1.7	1.0	1.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.3	-0.3	0.5	-0.2	0.3
Condit. Reinf. active responses	3.4	4.2	5.7	-2.4	-2.1	2.0	1.4	2.3
Condit. Reinf. inactive responses	1.7	2.0	2.9	-1.7	-1.3	1.1	1.2	1.7
Incentive salience index mean	4.1	5.0	6.2	-2.5	-2.3	2.3	1.6	2.4
Condit. Reinf. lever presses	4.5	6.1	8.5	-2.8	-2.5	2.2	1.8	2.9
Condit. Reinf. active minus inactive responses	0.6	0.7	1.9	-1.0	-0.6	0.6	0.2	1.4
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.9	-1.1	-1.0	0.9	0.5	1.4
Condit. Reinf. active responses	0.9	1.2	2.5	-1.2	-0.9	1.0	0.5	1.6
Condit. Reinf. inactive responses	0.3	0.4	0.8	0.6	0.9	-0.5	-0.8	-0.3
Condit. Reinf. lever presses	4.4	6.0	7.4	-2.5	-2.3	2.6	2.0	2.7
Condit. Reinf. lever reinforcers received	1.3	1.8	3.5	-1.5	-1.1	1.2	0.7	1.9
Conditioned reinforcement - actives	8.5	8.5	12.4	2.7	3.3	-2.9	-3.5	-1.9
Conditioned reinforcement - inactives	3.7	4.2	4.8	2.2	2.1	-2.0	-2.1	-1.9
Conditioned locomotion	3.8	4.5	5.8	2.1	2.4	-2.1	-2.4	-1.6
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.5	0.3	-0.3	0.0	-0.7
Patch foraging indifference point AUC	0.1	0.1	0.3	0.0	-0.2	0.6	0.1	-0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.1	-0.1	0.4	0.6	-0.2
Delay disc. indifference point, 16s delay	0.6	0.7	1.2	-0.8	-0.7	0.7	1.1	0.7
Delay disc. indifference point, 2s delay	1.7	1.8	3.0	-1.4	-1.2	1.7	1.2	1.2
Delay disc. indifference point, 24s delay	0.8	0.8	1.0	-0.8	-0.8	1.0	0.8	0.9
Delay disc. indifference point, 4s delay	3.7	3.9	4.4	-2.1	-2.0	2.0	2.0	1.8
Delay disc. indifference point, 8s delay	2.5	2.5	3.1	-1.5	-1.6	1.7	1.8	1.4
Indifference point function ln k	0.3	0.4	0.6	-0.8	-0.6	0.1	0.8	0.6
Indifference point function log k	0.3	0.4	0.6	-0.8	-0.6	0.1	0.8	0.6
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.0	-0.1	0.1	0.4	-0.3
Patch foraging total patch changes 12 sec	0.4	0.5	1.1	-0.5	-0.7	1.1	0.7	0.3
Patch foraging total patch changes 18 sec	0.1	0.1	0.5	-0.2	-0.3	0.7	0.2	-0.2
Patch foraging total patch changes 24 sec	0.4	0.5	1.0	-0.6	-0.7	1.0	0.8	0.3
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.2	-0.0	0.4	0.1	-0.3
Patch foraging time to switch 0 sec	0.2	0.2	0.5	0.7	0.7	-0.3	-0.4	-0.3
Patch foraging water rate 0 sec	0.9	1.5	2.0	-1.4	-1.4	0.7	1.4	1.0
Patch foraging water rate 12 sec	3.0	4.6	6.2	-2.5	-2.2	1.8	2.0	2.2
Patch foraging water rate 18 sec	6.9	9.3	11.1	-3.2	-3.2	2.7	3.3	2.6
Patch foraging water rate 24 sec	0.7	1.0	1.9	-1.4	-1.1	0.7	0.8	1.0
Patch foraging water rate 6 sec	2.3	3.3	4.3	-2.1	-1.9	1.6	1.8	1.7
Seeking ratio, delayed vs. immediate footshock	1.4	1.7	2.3	1.3	1.4	-1.5	-1.1	-1.1
Distance traveled before self-admin	0.1	0.1	0.3	-0.1	0.1	0.5	-0.2	0.1
Distance traveled after self-admin	0.5	0.6	0.8	0.7	0.9	-0.8	-0.7	-0.8
Extensor digitorum longus weight	7.1	28.0	32.6	-5.1	-5.3	5.7	5.6	4.7
Bone: elastic displacement	0.4	0.5	0.7	0.7	0.7	-0.8	-0.3	-0.9
Bone: elastic work	0.1	0.2	0.2	-0.4	-0.4	0.4	0.5	0.1
Bone: endosteal estimation	0.4	0.8	1.1	1.1	0.9	-0.9	-0.5	-1.1
Bone: endosteal perimeter	0.9	2.0	2.7	1.5	1.4	-1.7	-0.8	-1.5
Epididymis fat weight	0.3	0.6	1.2	0.8	0.8	-0.5	-0.5	-1.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	0.4	0.3	0.3	-0.3	-0.8
Delta time in open arm before/after self-admin	3.3	3.2	4.0	1.8	1.7	-2.0	-1.8	-1.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	0.3	0.0	-0.2	0.3	-0.6
Delay discount exponential model param	4.4	4.6	5.7	2.1	2.1	-2.4	-2.2	-1.9
Extinction: sum of active levers before priming	0.2	0.2	0.4	0.3	0.5	-0.1	-0.6	-0.2
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	0.3	0.1	-0.2	-0.3
Bone: final force	0.7	1.1	2.1	-0.9	-1.0	1.5	1.1	0.9
Bone: final moment	1.0	1.6	2.6	-1.1	-1.1	1.6	1.2	1.1
Food consumed during 24 hour testing period	0.3	0.3	0.5	-0.6	-0.6	0.6	0.4	0.7
Glucose	0.3	0.5	0.9	-0.7	-0.9	0.8	0.5	0.6
Heart weight	0.2	0.3	0.8	-0.7	-0.6	0.2	0.0	0.9
Delay discount hyperbolic model param	4.5	4.7	5.8	2.2	2.1	-2.4	-2.1	-2.0
Intermittent access intake day 1-15 change	1.6	1.5	2.1	1.2	1.2	-0.8	-1.4	-1.4
Intermittent access intake escalation	2.1	2.1	3.1	1.4	1.4	-1.0	-1.8	-1.5
Intermittent access intake escalation 2	0.8	0.8	1.4	0.8	0.8	-0.7	-1.2	-0.9
Intermitt. access day 1 inactive lever presses	5.0	5.3	7.1	2.7	2.3	-2.4	-2.1	-2.1
Intermitt. access day 15 inactive lever presses	1.5	1.7	2.2	1.4	1.2	-1.5	-1.3	-1.0
Intermitt. access escalation Index	0.3	0.2	0.4	-0.3	-0.5	0.6	0.2	0.6
Intermittent access day 1 total infusions	0.5	0.5	0.8	0.9	0.9	-0.7	-0.5	-0.7
Intermittent access day 15 total infusions	3.5	3.9	4.5	2.1	2.1	-1.7	-2.0	-1.9
Intermittent access terminal intake (last 3 days)	3.1	3.4	4.0	2.0	1.8	-1.8	-1.6	-2.0
Intermittent access total infusions	4.0	4.4	5.2	2.3	2.2	-2.0	-2.0	-2.0
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.5	0.4	-0.3	0.0	-0.2
Intermittent access day 15 total locomotion	2.9	3.1	3.7	1.9	1.8	-1.4	-1.7	-1.8
Intermittent access total locomotion	1.7	2.0	2.3	1.5	1.5	-1.3	-1.4	-1.4
Intermittent access standard deviation	1.4	1.5	2.0	1.3	1.3	-1.1	-1.0	-1.4
Left kidney weight	2.7	7.7	9.3	-2.9	-3.0	2.2	2.8	2.9
Right kidney weight	3.9	10.9	13.1	-3.6	-3.4	2.8	3.0	3.6
Cocaine induced anxiety	0.3	0.3	0.5	-0.7	-0.5	0.5	0.7	0.4
Post-drug Anxiety	0.0	0.0	0.1	-0.1	-0.1	0.1	0.3	-0.3
Baseline Anxiety	0.0	0.0	0.1	0.1	0.1	-0.3	-0.2	-0.1
Tail length	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	0.1
Length with tail	0.1	0.3	0.7	-0.4	-0.5	0.6	0.9	0.2
Length without tail	0.5	1.1	1.7	-1.1	-1.2	0.8	1.3	0.7
Times rat made contact with spout	0.5	0.5	1.1	-0.5	-0.7	1.1	0.9	0.2
Lifetime Intake	4.1	4.7	5.5	2.3	2.3	-2.0	-2.2	-2.0
Liver weight, left	4.5	7.3	9.0	-2.8	-2.7	3.0	2.2	2.7
Liver weight, right	0.1	0.2	0.3	-0.4	-0.3	0.6	0.4	0.4
Locomotor activity	3.4	5.4	6.2	-2.3	-2.4	2.3	2.5	2.1
Locomotor testing distance	0.3	0.5	0.9	-0.7	-0.8	0.7	1.0	0.4
Locomotor testing rearing	0.1	0.2	0.3	-0.4	-0.4	-0.0	0.6	0.5
Locomotion in novel chamber	1.6	1.9	2.8	-1.3	-1.3	1.5	1.7	1.1
Locomotion in novel chamber post-restriction	0.2	0.2	0.6	0.4	0.1	-0.0	0.8	-0.6
Fecal boli incidents, locomotor time 1	3.0	3.3	3.6	-1.8	-1.9	1.9	1.7	1.8
Change in fecal boli incidents, locomotor task	1.9	1.8	3.1	1.6	1.3	-1.1	-0.7	-1.8
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.2	-0.2	0.4	0.1	0.1
Bouts of movement, locomotor time 1	0.6	0.7	1.5	-0.7	-1.0	0.7	1.2	0.4
Total resting periods, locomotor time 1	0.5	0.5	1.1	-0.6	-0.9	0.6	1.0	0.3
Rest time, locomotor task time 1	3.1	3.4	4.6	-1.9	-2.1	1.7	1.6	1.8
Distance moved, locomotor task time 1	1.8	2.0	2.8	1.3	1.7	-1.3	-1.5	-1.2
Vertical activity count, locomotor time 1	1.5	1.5	2.3	1.3	1.5	-1.2	-0.9	-1.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.3	0.3	-0.5	-0.3	-0.3
Bouts of movement, locomotor time 2	0.2	0.2	0.4	-0.3	-0.5	0.3	0.6	0.4
Total resting periods, locomotor time 2	0.5	0.6	0.9	-0.6	-0.9	0.7	0.9	0.6
Rest time, locomotor task time 2	2.7	3.1	4.4	-1.8	-2.1	1.5	1.8	1.6
Distance moved, locomotor task time 2	0.4	0.4	0.9	0.4	0.9	-0.7	-0.7	-0.2
Vertical activity count, locomotor time 2	0.6	0.7	1.6	0.6	1.3	-0.7	-0.9	-0.4
Light reinforcement 1	0.3	0.6	1.0	-0.6	-0.8	0.9	1.0	0.2
Light reinforcement 2	1.1	1.4	2.2	1.3	1.3	-1.0	-0.7	-1.5
Bone: marrow area	0.4	0.9	1.3	1.1	0.9	-0.9	-0.5	-1.1
Bone: maximum diameter	0.6	1.2	1.6	1.3	1.1	-1.1	-0.6	-1.2
Bone: maximum force	0.4	0.7	1.5	-0.7	-0.8	1.2	0.9	0.6
Bone: maximum moment	0.7	1.2	2.1	-1.0	-1.0	1.4	1.0	0.9
Mean time between licks in bursts	0.8	1.1	1.5	1.0	1.0	-0.9	-1.2	-1.0
Mean num. licks in bursts	0.0	0.0	0.0	-0.1	-0.2	0.2	0.1	0.1
Cd content in liver	0.7	0.8	1.1	0.9	0.8	-1.0	-0.9	-0.8
Co content in liver	0.2	0.2	0.4	-0.4	-0.5	0.4	0.7	0.3
Cu content in liver	1.3	1.6	2.1	-1.1	-1.4	1.2	1.5	1.0
Fe content in liver	0.2	0.3	0.4	0.5	0.4	-0.5	-0.6	-0.4
K content in liver	0.4	0.4	1.2	0.7	0.6	-0.1	-0.2	-1.1
Mg content in liver	1.7	1.7	2.9	1.4	1.3	-0.9	-1.0	-1.7
Mn content in liver	1.2	1.4	1.6	1.1	1.3	-1.0	-1.2	-1.2
Na content in liver	2.8	2.9	3.3	-1.8	-1.7	1.8	1.7	1.6
Rb content in liver	4.7	5.8	7.0	2.5	2.5	-2.1	-2.2	-2.6
Se content in liver	2.7	3.4	3.8	1.9	1.9	-1.8	-1.6	-1.9
Sr content in liver	0.3	0.2	0.4	0.4	0.3	-0.6	-0.6	-0.4
Zn content in liver	1.1	1.2	1.7	-1.0	-1.0	1.3	1.1	1.0
Bone: minimum diameter	0.1	0.2	0.4	0.6	0.4	-0.4	-0.3	-0.6
Time in familiar zone, hab. session 1	0.3	0.3	0.5	-0.6	-0.4	0.4	-0.0	0.7
Time in novel zone, hab. session 1	0.5	0.5	1.0	0.9	0.5	-0.5	0.0	-1.0
Total zone transitions, hab. session 1	0.7	0.9	1.8	-0.9	-1.0	0.8	1.4	0.7
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.1	-0.2	0.4	0.2	-0.1
Locomotion velocity, hab. session 1	0.1	0.2	0.3	-0.4	-0.4	0.5	0.4	0.3
Time in familiar zone, hab. session 2	0.5	0.5	0.7	0.5	0.8	-0.8	-0.7	-0.5
Time in novel zone, hab. session 2	0.2	0.2	0.4	-0.2	-0.6	0.6	0.6	0.2
Total zone transitions, hab. session 2	2.2	2.8	3.8	-1.6	-1.7	1.7	2.0	1.4
Total locomotion distance, hab. session 2	1.1	1.4	2.7	-0.9	-1.2	1.3	1.7	0.6
Locomotion velocity, hab. session 2	1.4	1.8	3.2	-1.1	-1.4	1.5	1.8	0.8
Novel to familiar place preference ratio	1.8	1.9	2.3	1.5	1.2	-1.5	-1.1	-1.4
Novelty place preference	1.7	1.7	2.1	1.4	1.1	-1.4	-1.0	-1.4
Time in novel zone, NPP test	1.5	1.6	1.9	1.4	1.1	-1.4	-1.0	-1.3
Total zone transitions, NPP test	1.2	1.7	1.9	-1.3	-1.4	1.2	1.4	1.3
Total locomotion distance, NPP test	0.0	0.0	0.1	0.2	-0.0	-0.3	-0.0	-0.0
Locomotion velocity, NPP test	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1
Intraocular pressure	1.7	2.3	3.5	1.2	1.7	-1.7	-1.9	-0.9
Delta distance traveled before/after self-admin	1.1	1.2	2.6	1.0	0.9	-1.6	-0.8	-1.0
Delta ambulatory time before/after self-admin	0.8	0.9	1.9	0.9	0.9	-1.4	-0.7	-0.7
Parametrial fat weight	3.5	6.8	9.2	2.8	2.8	-2.0	-2.3	-3.0
Pavlov. Cond. lever latency	1.6	2.0	3.7	1.5	1.4	-1.0	-1.0	-1.9
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	-0.6	-0.3	0.1	-0.2	0.7
Pavlov. Cond. change in total contacts	0.9	1.0	1.8	-1.2	-1.0	0.5	0.6	1.3
Pavlov. Cond. index score	2.5	3.2	5.0	-2.0	-1.8	1.3	1.4	2.2
Pavlov. Cond. latency score	2.2	2.8	4.9	-1.9	-1.7	1.1	1.2	2.2
Pavlov. Cond. lever contacts	2.1	2.5	4.5	-1.8	-1.6	1.0	1.1	2.1
Pavlov. Cond. magazine entry number	0.9	1.2	1.9	1.3	1.1	-0.8	-0.7	-1.4
Pavlov. Cond. intertrial magazine entries	1.6	1.9	2.4	-1.6	-1.4	1.5	1.0	1.4
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.4	5.2	-2.0	-1.9	1.3	1.5	2.3
Pavlov. Cond. response bias	2.6	3.2	4.9	-2.0	-1.8	1.4	1.3	2.2
Pavlov. Cond. lever latency	4.5	6.1	6.7	2.5	2.4	-2.6	-2.3	-2.5
Pavlov. Cond. magazine entry latency	1.9	2.2	2.9	-1.7	-1.3	1.4	1.2	1.7
Pavlov. Cond. change in total contacts	4.9	6.8	7.2	-2.7	-2.5	2.7	2.5	2.7
Pavlov. Cond. index score	4.6	5.9	7.1	-2.6	-2.3	2.4	2.1	2.7
Pavlov. Cond. latency score	4.4	5.5	6.9	-2.5	-2.2	2.3	2.0	2.6
Pavlov. Cond. lever contacts	4.1	5.6	6.2	-2.4	-2.3	2.5	2.3	2.4
Pavlov. Cond. magazine entry number	2.0	2.5	2.9	1.7	1.5	-1.6	-1.4	-1.7
Pavlov. Cond. intertrial magazine entries	2.2	2.9	3.4	1.9	1.6	-1.5	-1.8	-1.7
Pavlov. Cond. lever-magazine prob. diff.	4.2	5.4	6.6	-2.5	-2.2	2.3	2.0	2.6
Pavlov. Cond. response bias	4.6	6.3	7.1	-2.6	-2.4	2.6	2.3	2.7
Time in closed arm before self-admin	2.1	2.4	3.9	-1.4	-1.6	1.6	2.0	1.2
Time in closed arm after self-admin	3.5	3.6	5.6	-1.7	-1.8	2.4	2.1	1.3
Time in open arm before self-admin	0.2	0.2	0.4	-0.6	-0.4	0.5	0.4	0.4
Time in open arm after self-admin	2.3	2.5	3.1	1.6	1.4	-1.7	-1.8	-1.4
Bone: periosteal estimation	0.4	0.8	1.1	1.1	0.9	-0.9	-0.6	-1.0
Bone: periosteal perimeter	0.3	0.5	0.8	0.8	0.7	-0.9	-0.4	-0.8
Bone: post-yield work	0.1	0.1	0.3	0.1	0.0	0.5	0.3	-0.1
Progressive ratio test 1 active lever presses	0.6	0.6	0.9	1.0	0.8	-0.6	-0.4	-0.9
Progressive ratio test 1 breakpoint	0.6	0.6	1.1	1.0	0.8	-0.7	-0.4	-1.0
Progressive ratio test 1 inactive lever presses	1.0	1.1	1.7	1.3	1.1	-1.0	-0.7	-1.0
Progressive ratio test 2 active lever presses	3.7	4.0	5.1	2.2	2.0	-1.7	-2.3	-1.8
Progressive ratio test 2 breakpoint	2.5	2.8	3.4	1.9	1.6	-1.4	-1.8	-1.7
Progressive ratio test 2 inactive lever presses	1.2	1.4	2.2	1.3	1.2	-1.0	-1.5	-0.9
Incentive Sensitization - Responses	2.4	2.5	4.7	1.5	1.4	-1.3	-2.2	-1.3
Incentive Sensitization - Breakpoint	2.2	2.2	4.2	1.4	1.3	-1.2	-2.0	-1.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.0	-0.0	-0.1	-0.0	0.2
Progressive ratio	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.5	0.2
Food seeking constrained by brief footshock	0.3	0.4	0.9	0.5	0.6	-0.7	-1.0	-0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.0	0.1	0.4	-0.4	0.1
Retroperitoneal fat weight	0.4	1.3	1.8	1.1	1.3	-0.8	-1.0	-1.3
Reaction time number correct	0.0	0.0	0.1	0.2	0.2	-0.1	-0.2	-0.2
Reaction time mean minus median	0.1	0.2	0.4	-0.5	-0.2	0.4	-0.1	0.7
Reaction time mean minus median AUC	0.1	0.1	0.3	-0.3	-0.1	0.3	-0.2	0.5
Reaction time num false alarms	0.2	0.3	0.5	-0.4	-0.6	0.7	0.6	0.1
Reaction time num false alarms AUC	0.4	0.6	1.0	-0.7	-0.9	1.0	0.9	0.3
Reaction time trials correct on left	0.0	0.0	0.1	0.2	0.2	-0.1	-0.2	-0.2
Reaction time trials on left	0.0	0.1	0.1	0.3	0.2	-0.2	-0.3	-0.3
Reaction time mean	0.4	0.6	1.1	0.6	0.8	-0.9	-1.0	-0.3
Reaction time mean AUC	0.5	0.7	1.2	0.7	0.9	-1.0	-1.1	-0.3
Median of all reaction times	0.7	1.0	1.6	0.8	1.0	-1.3	-1.2	-0.5
Reaction time omissions	1.4	1.9	2.6	1.3	1.3	-1.4	-1.6	-1.0
Reaction time false alarm rate	0.5	0.7	0.9	-0.7	-0.9	0.9	1.0	0.4
Reaction time premature initiation rate	0.2	0.3	0.4	-0.6	-0.4	0.6	0.6	0.5
Reaction time premature initiations	0.1	0.1	0.1	-0.3	-0.2	0.4	0.3	0.2
Std. dev. reaction times	0.2	0.3	0.7	0.4	0.6	-0.5	-0.8	-0.1
Reaction time trials completed	0.0	0.1	0.1	0.3	0.2	-0.2	-0.3	-0.3
Reaction time trials AUC	0.1	0.1	0.1	0.3	0.3	-0.2	-0.2	-0.4
Run reversals in cocaine runway, females	1.0	0.9	1.2	0.9	1.1	-1.1	-0.9	-0.9
Run reversals in cocaine runway, males	1.0	0.9	1.3	-1.1	-0.8	1.1	0.6	1.0
Latency to leave start box in cocaine runway	0.7	0.7	0.9	0.9	0.8	-0.8	-0.8	-1.0
Latency to leave start box in cocaine runway, F	1.4	1.5	2.0	1.2	1.1	-1.4	-1.4	-1.0
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.3	-0.4	0.7	0.4	0.1
Std. dev. time between licks in bursts	2.3	2.8	3.4	1.5	1.8	-1.7	-1.8	-1.5
Total sessions with >9 infusions	5.6	6.2	7.0	2.6	2.6	-2.6	-2.5	-2.1
Short access day 1 total inactive lever presses	0.2	0.2	0.3	0.6	0.5	-0.5	-0.2	-0.1
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.1	-0.2	-0.2	0.0	0.3
Short access day 1 total infusions	5.6	6.0	7.0	2.6	2.6	-2.5	-2.3	-2.1
Short access day 10 total infusions	0.5	0.5	0.7	0.8	0.8	-0.8	-0.4	-0.7
Short access total infusions	2.5	2.9	3.5	1.8	1.9	-1.6	-1.5	-1.6
Short access day 1 locomotion	1.9	2.1	2.7	1.6	1.5	-1.7	-1.2	-1.1
Short access day 10 total locomotion	0.1	0.1	0.4	-0.3	-0.2	0.2	0.2	0.6
Short access total locomotion	0.3	0.3	0.7	0.4	0.5	-0.9	-0.5	-0.0
One hour access (0.3 mA shock)	2.1	2.5	5.3	1.3	1.6	-1.3	-2.3	-0.9
Compulsive drug intake	1.4	1.5	2.6	-1.3	-1.1	1.1	0.8	1.6
One hour access (shock baseline)	5.3	6.2	7.5	2.5	2.5	-2.3	-2.7	-2.3
Social response proportion	3.0	3.2	4.5	1.9	1.8	-2.1	-1.7	-1.4
Social responses	1.4	1.8	3.2	1.2	1.3	-1.5	-1.8	-0.6
Social time	0.8	1.0	1.8	-0.8	-1.2	0.8	1.3	0.9
Soleus weight	0.6	1.7	2.4	-1.4	-1.2	1.5	0.8	1.4
Bone: stiffness	0.1	0.2	0.5	-0.2	-0.5	0.7	0.6	0.1
Tibialis anterior weight	8.0	27.5	31.9	-5.0	-5.3	5.7	5.5	4.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.6	-0.2	-0.0	0.8	0.2	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.1	-0.3	0.3	0.6	-0.4
Time to tail flick, test, before self-admin	1.3	1.3	2.3	-1.1	-1.0	1.5	1.2	0.8
Time to tail flick, test, after self-admin	1.4	1.5	2.4	1.2	1.4	-0.9	-1.6	-0.8
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.5	0.0	-0.6	0.1	-0.7
Delta time to tail flick, test, before/after SA	2.3	2.0	3.3	1.3	1.5	-1.5	-1.8	-0.8
Tibia length	0.8	2.3	3.0	-1.4	-1.7	1.6	1.5	1.2
Ambulatory time before self-admin	0.6	0.7	1.3	-0.9	-0.6	1.1	0.5	0.8
Ambulatory time after self-admin	0.0	0.1	0.2	-0.2	-0.1	0.1	0.4	0.2
Bone: tissue strength	0.4	0.3	0.8	0.5	0.6	-0.2	-0.9	-0.6
Total heroin consumption	0.5	0.6	1.4	-0.9	-0.7	0.6	-0.1	1.2
Bone: trabecular number	0.5	0.9	1.6	1.0	0.8	-1.2	-0.6	-0.9
Bone: trabecular spacing	0.2	0.2	0.5	-0.5	-0.3	0.7	0.3	0.6
Bone: trabecular thickness	0.8	0.9	1.5	-0.9	-1.1	0.8	1.2	0.7
Bone: trabecular tissue density	0.7	0.9	1.2	-1.0	-1.0	1.1	0.8	0.9
Water consumed over 24 hours	0.5	0.7	0.7	-0.8	-0.8	0.8	0.7	0.9
Number of responses in last shaping day	1.7	1.8	2.5	1.3	1.2	-1.6	-1.1	-1.4