Fen1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	intron excision ratio	chr1_216271952_216274150	0.1	0.07	4.1e-04	0	0.03	0.03	0.02	2.4e-01	8.2e-03	1.0e-02	4.6e-02
2	BLA	alternative TSS	NM_053430.3	0.1	0.08	2.3e-03	0.03	0.03	0.02	0.01	1.6e-02	1.4e-02	4.0e-02	5.4e-02
3	Brain	alternative TSS	XM_008760245.4	0.03	0.02	4.2e-03	0	0.02	0	0.01	1.3e-01	7.2e-03	2.2e-01	8.1e-02
4	IC	isoform ratio	XM_006231072.5	0.14	0.11	2.9e-03	-0	0.02	0	-0	3.6e-01	3.8e-02	2.2e-01	3.6e-01
5	Brain	gene expression	Fen1	0.04	0.03	2.0e-03	0.04	0.03	0.02	0.04	8.0e-05	8.2e-04	2.5e-03	2.7e-04
6	BLA	alternative TSS	XM_008760245.4	0.1	0.06	1.7e-03	0.04	0.03	0.03	0.03	3.7e-03	7.5e-03	6.6e-03	7.5e-03
7	BLA	gene expression	Fen1	0.1	0.07	7.7e-04	0.03	0.05	0.03	0.02	1.7e-02	1.8e-03	1.5e-02	2.1e-02
8	NAcc	gene expression	Fen1	0.04	0.03	4.0e-04	0.02	0.02	0.02	0.01	1.0e-03	9.1e-04	9.8e-04	2.2e-03
9	BLA	isoform ratio	NM_053430.3	0.12	0.08	3.3e-04	0.06	0.06	0.06	0.06	3.0e-04	5.9e-04	6.5e-04	3.5e-04
10	Brain	isoform ratio	XM_008760245.4	0.05	0.04	1.0e-03	0.03	0.02	0.02	0.02	6.8e-04	2.6e-03	9.5e-03	5.3e-03
11	BLA	isoform ratio	XM_008760245.4	0.11	0.07	1.5e-03	0.03	0.04	0.04	0.03	7.2e-03	4.5e-03	5.4e-03	7.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.2	0.3	0.8	-0.2	-0.3	0.2	0.1	0.5	0.5	0.7	0.8	-0.6	0.6	0.9
Area under the delay curve	0.6	0.7	2.1	-0.6	-0.7	0.5	0.1	0.3	0.5	0.9	0.9	-1.4	1.4	0.9
BMI with tail	0.5	1.8	6.5	0.8	-0.0	-0.8	-0.4	1.3	1.3	1.8	1.9	-0.9	0.9	2.5
BMI without tail	0.1	0.2	0.4	0.5	0.2	-0.6	-0.6	0.1	0.1	0.3	0.4	-0.2	0.2	0.6
Body weight	0.3	1.4	3.6	1.8	1.1	-1.9	-1.9	-0.1	-0.1	0.7	0.9	-0.5	0.5	1.6
Weight adjusted by age	0.9	1.3	2.8	1.5	1.3	-1.5	-0.7	-0.4	-0.6	-0.8	-0.8	1.7	-1.7	-0.5
Bone surface	0.3	0.5	1.5	0.4	0.2	-0.4	-0.7	0.1	0.1	0.8	1.0	-0.9	0.9	1.2
Bone volume	0.3	0.6	1.8	-0.1	-0.3	0.2	-0.0	0.6	0.5	1.0	1.2	-0.9	0.9	1.3
Breakpoint value in progressive ratio session	3.7	4.4	5.5	2.4	2.3	-2.3	-2.1	-2.1	-2.2	-1.9	-1.9	2.1	-2.1	-1.6
Number of licking bursts	0.1	0.2	0.6	-0.2	-0.3	0.2	0.2	-0.1	-0.1	0.3	0.2	-0.8	0.8	0.3
Context. condit. distance diff. score	0.1	0.1	0.3	-0.3	-0.3	0.2	0.5	0.6	0.5	0.3	0.2	-0.2	0.2	0.2
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	0.4	-0.4	-0.2	0.2	0.3	-0.2	-0.2	0.4	-0.4	-0.2
Locomotion distance, session 1	0.2	0.3	1.0	0.9	0.8	-1.0	-0.7	0.0	0.0	-0.3	-0.2	0.4	-0.4	-0.0
Locomotion velocity, session 2	0.6	0.7	1.9	1.3	1.1	-1.4	-1.3	-0.6	-0.6	-0.3	-0.2	0.4	-0.4	0.1
Locomotion distance, session 2	0.4	0.5	1.1	1.0	0.8	-1.1	-0.8	-0.5	-0.5	-0.6	-0.7	0.7	-0.7	-0.5
Locomotion velocity, session 3	1.2	1.4	2.8	-0.6	-0.9	0.5	0.6	1.3	1.3	1.5	1.5	-1.3	1.3	1.7
Locomotion distance, session 3	0.2	0.2	0.3	-0.5	-0.4	0.4	-0.0	0.3	0.3	0.4	0.5	-0.5	0.5	0.4
Stereotopy head waving bouts, day 3	1.2	1.4	2.0	-0.9	-1.1	0.7	0.8	1.3	1.4	1.4	1.4	-1.1	1.1	1.4
Stereotopy head waving duration, day 3	0.3	0.4	0.7	-0.4	-0.6	0.3	0.4	0.6	0.7	0.8	0.7	-0.8	0.8	0.8
Locomotion velocity, session 7	0.4	0.4	1.2	-0.5	-0.6	0.4	0.2	0.2	0.3	0.7	0.7	-1.1	1.1	0.7
Locomotion distance, session 7	0.3	0.4	0.9	-0.5	-0.6	0.4	0.3	0.4	0.5	0.6	0.5	-0.9	0.9	0.5
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	0.2	0.1	-0.2	-0.1	0.2	0.2	0.2	0.3	0.2	-0.2	0.4
Stereotopy head waving duration, day 7	0.3	0.4	1.2	0.9	0.8	-0.9	-1.1	-0.6	-0.6	-0.3	-0.1	0.3	-0.3	0.0
Locomotion velocity, session 8	0.3	0.3	0.6	0.3	0.4	-0.4	-0.7	-0.7	-0.7	-0.7	-0.7	0.3	-0.3	-0.8
Locomotion distance, session 8	0.2	0.3	0.7	-0.4	-0.5	0.3	0.6	0.8	0.8	0.6	0.5	-0.5	0.5	0.5
Degree of sensitization distance	0.6	0.6	1.1	-0.3	-0.6	0.2	0.7	0.9	0.9	0.9	0.9	-0.7	0.7	1.1
Degree of sensitization stereotypy	0.3	0.3	0.8	0.9	0.8	-0.8	-0.7	-0.4	-0.4	-0.2	-0.1	0.7	-0.7	0.1
Conditioned locomotion	0.2	0.2	0.5	0.6	0.5	-0.7	-0.7	-0.6	-0.6	-0.3	-0.3	-0.1	0.1	-0.2
Cocaine response after cond. corrected	0.1	0.2	0.6	-0.3	-0.3	0.2	0.7	0.7	0.6	0.2	0.1	0.1	-0.1	0.1
Cocaine response after cond. not corrected	0.2	0.3	0.7	-0.2	-0.3	0.3	0.8	0.9	0.9	0.3	0.3	0.3	-0.3	0.3
Cocaine response before conditioning	0.2	0.2	0.9	0.5	0.6	-0.3	-0.3	-0.3	-0.1	-0.1	0.1	1.0	-1.0	0.1
Saline control response	1.8	2.3	4.3	1.9	1.8	-1.9	-2.1	-1.6	-1.5	-1.3	-1.1	1.1	-1.1	-0.9
Bone: connectivity density	0.2	0.2	0.6	0.6	0.4	-0.6	-0.7	0.1	0.1	0.4	0.6	-0.2	0.2	0.8
Bone: cortical apparent density	0.9	1.2	1.4	1.0	1.1	-1.0	-1.0	-1.2	-1.1	-1.1	-1.0	1.2	-1.2	-1.0
Bone: cortical area	0.1	0.1	0.4	0.4	0.4	-0.4	-0.7	-0.2	-0.2	0.1	0.3	-0.1	0.1	0.3
Bone: cortical porosity	1.0	1.1	1.9	0.8	1.0	-0.8	-0.9	-1.3	-1.3	-1.3	-1.4	0.5	-0.5	-1.4
Bone: cortical porosity	1.1	1.2	1.9	1.0	1.1	-1.0	-1.1	-1.3	-1.3	-1.3	-1.4	0.5	-0.5	-1.3
Bone: cortical thickness	3.6	5.9	8.8	2.6	2.7	-2.6	-3.0	-2.6	-2.5	-2.4	-2.2	2.0	-2.0	-2.0
Bone: cortical thickness	0.8	0.9	1.2	0.8	0.9	-0.8	-1.0	-1.0	-0.9	-1.0	-0.9	1.1	-1.1	-0.9
Bone: cortical tissue density	1.2	1.6	1.9	1.2	1.3	-1.2	-1.2	-1.4	-1.3	-1.2	-1.2	1.4	-1.4	-1.1
Condit. Reinf. active minus inactive responses	0.8	0.9	2.0	1.3	1.2	-1.3	-0.8	-0.2	-0.2	-0.6	-0.5	1.4	-1.4	-0.4
Condit. Reinf. active-inactive response ratio	1.8	1.9	3.6	1.6	1.5	-1.5	-1.0	-0.8	-0.8	-1.3	-1.3	1.9	-1.9	-1.2
Condit. Reinf. active responses	0.3	0.4	0.9	0.9	0.7	-0.8	-0.3	0.4	0.3	0.0	0.1	0.9	-0.9	0.3
Condit. Reinf. inactive responses	0.9	1.1	1.7	-0.7	-0.9	0.7	1.1	1.3	1.3	1.2	1.2	-0.5	0.5	1.3
Incentive salience index mean	0.2	0.3	0.6	0.8	0.6	-0.7	-0.5	0.3	0.3	0.1	0.3	0.6	-0.6	0.4
Condit. Reinf. lever presses	0.3	0.5	1.4	-0.1	-0.2	0.1	-0.0	0.7	0.7	0.9	1.1	-0.5	0.5	1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.1	0.1	-0.0	0.4	0.1	0.2	-0.0	-0.0	0.6	-0.6	-0.0
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.7	-0.6	-0.8	0.7	1.3	0.9	0.9	1.0	0.9	-0.2	0.2	1.1
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	0.4	-0.3	-0.2	-0.2	-0.0	-0.2	-0.1	0.4	-0.4	-0.1
Condit. Reinf. inactive responses	0.2	0.3	0.6	0.5	0.6	-0.4	-0.8	-0.4	-0.3	-0.6	-0.5	0.4	-0.4	-0.6
Condit. Reinf. lever presses	0.1	0.1	0.6	0.5	0.3	-0.3	-0.1	0.2	0.2	0.5	0.5	0.0	-0.0	0.8
Condit. Reinf. lever reinforcers received	0.2	0.3	0.6	0.8	0.8	-0.7	-0.4	-0.5	-0.3	-0.4	-0.4	0.7	-0.7	-0.3
Conditioned reinforcement - actives	0.1	0.2	0.9	0.1	0.2	0.0	0.3	0.3	0.2	-0.2	-0.2	0.9	-0.9	-0.2
Conditioned reinforcement - inactives	0.6	0.9	2.0	-0.5	-0.7	0.6	1.0	1.4	1.1	1.1	1.2	-0.4	0.4	1.3
Conditioned locomotion	3.1	4.0	5.0	-2.0	-2.1	2.0	2.0	2.1	2.2	2.0	2.0	-1.7	1.7	1.9
Patch foraging indifference point 0 sec	0.1	0.3	0.7	0.6	0.6	-0.7	-0.8	-0.6	-0.7	-0.4	-0.3	-0.2	0.2	-0.2
Patch foraging indifference point AUC	0.9	1.3	1.9	1.4	1.4	-1.3	-1.4	-1.2	-1.3	-0.9	-0.8	0.9	-0.9	-0.7
Delay disc. indifference point, 0s delay	1.9	2.1	2.7	-1.2	-1.4	1.1	1.1	1.3	1.6	1.6	1.6	-1.6	1.6	1.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.1	-0.2	0.1	0.1	0.3	0.2	0.5	0.5	-0.5	0.5	0.6
Delay disc. indifference point, 2s delay	2.4	2.7	3.5	-1.5	-1.6	1.4	1.2	1.5	1.6	1.8	1.9	-1.9	1.9	1.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	-0.3	-0.3	0.2	-0.1	-0.1	0.2	0.4	0.4	-0.6	0.6	0.4
Delay disc. indifference point, 4s delay	0.8	0.8	2.7	-0.6	-0.7	0.4	-0.3	0.2	0.3	0.8	0.9	-1.6	1.6	0.9
Delay disc. indifference point, 8s delay	0.5	0.6	2.2	-0.8	-0.8	0.7	0.2	-0.1	0.1	0.4	0.4	-1.5	1.5	0.3
Indifference point function ln k	2.6	4.5	7.0	-2.4	-2.5	2.4	2.6	2.4	2.4	1.9	1.7	-1.6	1.6	1.5
Indifference point function log k	2.6	4.5	7.0	-2.4	-2.5	2.4	2.6	2.4	2.4	1.9	1.7	-1.6	1.6	1.5
Patch foraging total patch changes 0 sec	0.3	0.5	1.1	0.8	0.8	-0.9	-1.0	-0.8	-0.9	-0.7	-0.6	0.2	-0.2	-0.6
Patch foraging total patch changes 12 sec	5.0	6.5	9.8	3.0	2.9	-3.0	-3.1	-2.7	-2.8	-2.3	-2.1	1.8	-1.8	-1.7
Patch foraging total patch changes 18 sec	0.7	1.1	1.5	1.2	1.2	-1.2	-1.2	-1.1	-1.1	-1.0	-0.9	0.8	-0.8	-0.9
Patch foraging total patch changes 24 sec	1.3	2.2	5.2	2.1	1.8	-2.2	-2.3	-1.5	-1.6	-0.9	-0.7	0.5	-0.5	-0.3
Patch foraging total patch changes 6 sec	0.2	0.3	1.0	0.7	0.6	-0.7	-1.0	-0.7	-0.6	-0.3	-0.2	-0.3	0.3	-0.0
Patch foraging time to switch 0 sec	0.2	0.3	1.0	-0.1	-0.2	0.1	0.2	0.5	0.6	0.8	0.8	-0.5	0.5	1.0
Patch foraging water rate 0 sec	0.0	0.1	0.3	-0.4	-0.2	0.4	0.3	-0.0	-0.1	-0.3	-0.3	0.2	-0.2	-0.6
Patch foraging water rate 12 sec	0.4	0.9	1.8	-1.4	-1.2	1.3	1.3	1.0	1.0	0.5	0.4	-0.4	0.4	0.1
Patch foraging water rate 18 sec	0.4	0.6	1.1	-1.1	-1.0	1.0	0.7	0.8	0.8	0.6	0.6	-0.8	0.8	0.4
Patch foraging water rate 24 sec	0.3	0.4	1.0	-1.0	-0.8	1.0	1.0	0.5	0.5	0.1	0.0	-0.1	0.1	-0.2
Patch foraging water rate 6 sec	0.2	0.3	0.8	-0.9	-0.7	0.8	0.7	0.4	0.3	0.0	-0.1	-0.5	0.5	-0.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.8	-0.4	-0.5	0.3	0.4	0.4	0.5	0.7	0.7	-0.9	0.9	0.8
Distance traveled before self-admin	0.3	0.3	0.9	0.9	0.7	-0.8	-0.7	-0.3	0.0	0.1	0.3	0.6	-0.6	0.5
Distance traveled after self-admin	0.5	0.6	0.8	0.9	0.9	-0.8	-0.7	-0.8	-0.7	-0.7	-0.7	0.9	-0.9	-0.5
Extensor digitorum longus weight	1.6	6.3	14.6	3.7	3.1	-3.8	-3.6	-2.1	-2.1	-1.3	-1.1	1.7	-1.7	-0.2
Bone: elastic displacement	0.7	0.8	1.9	0.4	0.6	-0.4	-0.4	-0.7	-0.7	-1.1	-1.2	1.2	-1.2	-1.4
Bone: elastic work	1.6	2.1	2.7	1.4	1.5	-1.5	-1.6	-1.4	-1.4	-1.5	-1.4	1.4	-1.4	-1.4
Bone: endosteal estimation	4.1	9.1	10.1	-2.8	-3.1	2.9	2.9	3.1	3.1	3.2	3.1	-3.0	3.0	3.0
Bone: endosteal perimeter	5.7	12.2	13.7	-3.4	-3.6	3.4	3.5	3.5	3.5	3.7	3.6	-3.3	3.3	3.5
Epididymis fat weight	2.6	8.8	9.8	-2.8	-3.0	2.8	2.9	2.8	2.9	3.1	3.1	-3.1	3.1	3.0
Delta time in closed arm before/after self-admin	1.4	1.3	2.5	1.3	1.2	-1.5	-1.6	-1.1	-1.2	-1.1	-1.1	0.5	-0.5	-0.9
Delta time in open arm before/after self-admin	1.1	1.1	2.1	1.4	1.3	-1.3	-0.9	-0.9	-0.9	-0.6	-0.6	1.3	-1.3	-0.3
Diff in mean of infusions in LGA sessions	2.3	2.9	4.0	2.0	1.9	-2.0	-2.0	-1.8	-2.0	-1.5	-1.5	1.2	-1.2	-1.2
Delay discount exponential model param	0.7	0.7	2.1	0.6	0.7	-0.5	-0.1	-0.3	-0.5	-0.9	-0.9	1.5	-1.5	-1.0
Extinction: sum of active levers before priming	1.0	1.1	2.3	1.5	1.3	-1.5	-1.5	-1.0	-1.1	-0.6	-0.5	0.5	-0.5	-0.1
Active lever presses in extinction session 6	1.5	1.5	2.6	1.6	1.5	-1.5	-1.3	-1.1	-1.1	-0.9	-0.8	1.2	-1.2	-0.5
Bone: final force	0.1	0.2	0.6	0.7	0.6	-0.7	-0.8	-0.1	-0.0	0.1	0.3	0.1	-0.1	0.4
Bone: final moment	0.2	0.2	0.8	0.8	0.6	-0.8	-0.9	-0.2	-0.1	0.0	0.2	0.2	-0.2	0.4
Food consumed during 24 hour testing period	0.1	0.1	0.3	-0.2	-0.0	0.3	0.2	0.0	0.1	-0.2	-0.1	0.5	-0.5	-0.3
Glucose	4.1	6.5	7.5	-2.6	-2.7	2.6	2.6	2.7	2.7	2.4	2.3	-2.5	2.5	2.1
Heart weight	2.7	4.1	7.0	-1.7	-2.0	1.6	1.4	1.9	1.9	2.1	2.0	-2.7	2.7	2.0
Delay discount hyperbolic model param	0.9	1.0	2.5	0.8	0.9	-0.7	-0.2	-0.5	-0.7	-1.1	-1.1	1.6	-1.6	-1.1
Intermittent access intake day 1-15 change	0.4	0.7	1.6	-1.1	-0.9	1.2	1.3	1.0	1.0	0.7	0.7	-0.2	0.2	0.4
Intermittent access intake escalation	0.4	0.9	2.1	-1.1	-0.9	1.2	1.5	1.2	1.2	0.7	0.7	-0.1	0.1	0.4
Intermittent access intake escalation 2	0.3	0.3	0.7	-0.5	-0.4	0.6	0.8	0.9	0.6	0.5	0.5	0.0	-0.0	0.4
Intermitt. access day 1 inactive lever presses	0.1	0.3	1.0	-0.5	-0.5	0.6	1.0	0.7	0.8	0.4	0.3	0.3	-0.3	0.2
Intermitt. access day 15 inactive lever presses	1.0	2.0	5.3	-0.4	-0.8	0.5	0.8	1.7	1.7	1.9	2.0	-0.8	0.8	2.3
Intermitt. access escalation Index	0.6	0.8	1.6	-1.1	-1.0	1.0	0.7	0.9	0.6	0.6	0.6	-1.3	1.3	0.4
Intermittent access day 1 total infusions	4.9	7.9	11.5	-2.1	-2.5	2.1	2.3	3.2	3.1	3.2	3.3	-2.6	2.6	3.4
Intermittent access day 15 total infusions	5.7	8.6	11.9	-2.8	-2.9	2.9	3.1	3.4	3.3	3.0	3.0	-2.3	2.3	2.9
Intermittent access terminal intake (last 3 days)	5.0	6.6	10.3	-2.0	-2.3	2.1	2.5	3.2	3.0	2.9	2.9	-2.0	2.0	3.0
Intermittent access total infusions	6.3	7.4	10.4	-2.2	-2.5	2.3	2.5	3.2	3.1	3.0	3.1	-2.4	2.4	3.1
Intermittent access day 1 locomotion	2.5	3.1	5.2	-1.2	-1.5	1.2	1.4	2.1	2.1	2.1	2.1	-1.5	1.5	2.3
Intermittent access day 15 total locomotion	2.1	3.9	7.0	-1.2	-1.6	1.3	1.8	2.3	2.5	2.4	2.5	-1.2	1.2	2.6
Intermittent access total locomotion	7.7	9.2	15.3	-2.1	-2.5	2.2	2.6	3.6	3.6	3.6	3.7	-2.3	2.3	3.9
Intermittent access standard deviation	0.1	0.2	0.5	-0.3	-0.3	0.4	0.7	0.6	0.5	0.1	0.1	0.4	-0.4	-0.0
Left kidney weight	1.4	6.4	9.7	-2.2	-2.4	2.2	1.9	2.2	2.2	2.7	2.8	-3.1	3.1	2.7
Right kidney weight	0.7	3.3	4.9	-1.6	-1.7	1.5	1.4	1.5	1.6	2.0	2.0	-2.2	2.2	1.9
Cocaine induced anxiety	0.3	0.5	1.1	0.7	0.7	-0.6	-0.4	-0.4	-0.5	-0.7	-0.6	1.0	-1.0	-0.6
Post-drug Anxiety	0.1	0.1	0.2	0.4	0.3	-0.4	-0.3	0.0	0.1	0.0	0.1	0.4	-0.4	0.2
Baseline Anxiety	0.2	0.2	0.5	-0.1	-0.2	0.0	-0.2	0.0	0.3	0.5	0.5	-0.7	0.7	0.6
Tail length	0.6	2.4	3.5	1.4	1.5	-1.5	-1.9	-1.8	-1.8	-1.6	-1.6	1.1	-1.1	-1.6
Length with tail	0.5	2.0	4.8	1.8	1.7	-1.9	-2.2	-1.5	-1.5	-1.0	-0.9	0.7	-0.7	-0.5
Length without tail	0.7	2.2	5.6	2.2	1.9	-2.2	-2.4	-1.2	-1.2	-0.8	-0.6	0.8	-0.8	-0.1
Times rat made contact with spout	1.1	1.3	1.6	1.0	1.1	-1.0	-1.0	-1.0	-1.1	-1.3	-1.3	1.1	-1.1	-1.3
Lifetime Intake	4.4	5.4	7.6	-1.9	-2.1	1.9	2.1	2.8	2.6	2.6	2.6	-2.1	2.1	2.6
Liver weight, left	0.2	0.4	0.9	-0.9	-0.7	0.9	0.9	0.5	0.5	0.2	0.1	-0.5	0.5	-0.1
Liver weight, right	1.5	2.6	3.2	-1.8	-1.7	1.7	1.6	1.8	1.8	1.3	1.3	-1.7	1.7	1.0
Locomotor activity	0.1	0.2	0.5	-0.5	-0.3	0.4	-0.1	-0.3	-0.3	-0.4	-0.4	-0.4	0.4	-0.7
Locomotor testing distance	0.1	0.2	0.5	-0.7	-0.6	0.6	0.4	0.4	0.4	0.1	0.1	-0.4	0.4	-0.2
Locomotor testing rearing	0.1	0.2	0.4	-0.6	-0.4	0.5	0.6	0.4	0.5	-0.1	-0.1	-0.1	0.1	-0.4
Locomotion in novel chamber	2.2	2.8	4.0	-1.8	-1.7	1.8	1.8	2.0	1.7	1.6	1.6	-1.5	1.5	1.4
Locomotion in novel chamber post-restriction	0.2	0.3	1.0	-0.8	-0.6	0.8	1.0	0.5	0.3	0.0	-0.1	0.0	-0.0	-0.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.4	-0.0	-0.0	0.2	0.7	0.4	0.3	0.1	0.1	0.6	-0.6	0.1
Change in fecal boli incidents, locomotor task	2.2	2.1	3.1	-1.7	-1.7	1.6	1.1	1.2	1.5	1.3	1.3	-1.8	1.8	1.0
Time >=10cm from walls, locomotor time 1	2.3	2.5	4.6	-1.5	-1.6	1.7	2.1	1.9	1.7	1.6	1.5	-0.9	0.9	1.4
Bouts of movement, locomotor time 1	5.0	5.7	6.9	2.2	2.4	-2.1	-1.7	-2.4	-2.5	-2.5	-2.6	2.6	-2.6	-2.5
Total resting periods, locomotor time 1	3.3	3.6	4.4	1.8	2.0	-1.7	-1.4	-2.0	-2.0	-2.0	-2.0	2.1	-2.1	-1.9
Rest time, locomotor task time 1	0.4	0.5	1.3	-1.0	-0.8	1.0	1.1	0.5	0.3	0.4	0.2	-0.7	0.7	0.1
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.1	-0.0	-0.1	-0.1	0.5	0.5	0.3	0.4	0.1	-0.1	0.5
Vertical activity count, locomotor time 1	0.1	0.3	0.6	-0.8	-0.7	0.7	0.5	0.8	0.6	0.4	0.4	-0.3	0.3	0.2
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.3	-0.0	0.1	0.2	0.4	-0.1	-0.0	-0.1	-0.1	0.5	-0.5	-0.1
Bouts of movement, locomotor time 2	1.8	2.9	5.2	2.1	1.9	-2.0	-1.1	-1.2	-1.2	-1.5	-1.5	2.3	-2.3	-1.2
Total resting periods, locomotor time 2	1.2	2.1	4.1	1.8	1.6	-1.7	-0.7	-0.9	-1.0	-1.2	-1.3	2.0	-2.0	-1.0
Rest time, locomotor task time 2	0.7	0.9	2.6	-1.2	-1.2	1.2	1.6	1.1	0.8	0.5	0.3	-0.7	0.7	0.2
Distance moved, locomotor task time 2	0.6	0.7	1.1	0.8	0.9	-0.7	-1.1	-1.0	-0.9	-0.8	-0.7	0.8	-0.8	-0.8
Vertical activity count, locomotor time 2	0.5	0.7	1.5	0.3	0.5	-0.3	-0.8	-1.0	-1.0	-1.0	-1.0	0.5	-0.5	-1.2
Light reinforcement 1	0.0	0.0	0.1	-0.1	-0.0	0.2	0.2	0.2	0.3	0.1	0.2	0.1	-0.1	0.1
Light reinforcement 2	1.5	2.3	3.2	-1.3	-1.4	1.5	1.3	1.3	1.4	1.7	1.8	-1.5	1.5	1.8
Bone: marrow area	4.4	9.6	10.5	-3.0	-3.2	3.0	3.0	3.1	3.1	3.2	3.2	-3.1	3.1	3.1
Bone: maximum diameter	0.5	1.0	1.9	-0.6	-0.7	0.7	0.5	0.8	0.8	1.2	1.3	-1.2	1.2	1.4
Bone: maximum force	0.3	0.5	1.8	0.5	0.2	-0.5	-0.6	0.4	0.4	0.9	1.1	-0.4	0.4	1.3
Bone: maximum moment	0.2	0.4	1.5	0.6	0.3	-0.5	-0.7	0.2	0.3	0.7	0.9	-0.3	0.3	1.2
Mean time between licks in bursts	0.2	0.5	0.8	0.8	0.7	-0.9	-0.6	-0.3	-0.5	-0.7	-0.8	0.6	-0.6	-0.7
Mean num. licks in bursts	0.7	1.1	2.5	0.8	0.9	-0.8	-0.7	-0.5	-0.6	-1.2	-1.2	1.6	-1.6	-1.3
Cd content in liver	0.4	0.5	0.7	-0.8	-0.7	0.9	0.8	0.8	0.8	0.5	0.6	-0.6	0.6	0.4
Co content in liver	0.4	0.5	1.4	-0.1	0.2	0.0	-0.1	-0.6	-0.6	-0.9	-1.0	0.8	-0.8	-1.2
Cu content in liver	0.1	0.1	0.3	0.0	0.1	-0.1	-0.4	-0.4	-0.4	-0.4	-0.4	0.1	-0.1	-0.5
Fe content in liver	0.0	0.0	0.1	-0.1	-0.2	0.1	0.1	0.3	0.3	0.1	0.1	-0.0	0.0	0.1
K content in liver	0.3	0.2	0.6	-0.1	-0.2	0.1	-0.0	0.4	0.4	0.6	0.7	-0.7	0.7	0.8
Mg content in liver	0.5	0.5	0.8	-0.5	-0.6	0.4	0.3	0.8	0.8	0.8	0.9	-0.6	0.6	0.9
Mn content in liver	0.7	0.8	1.7	1.3	1.1	-1.3	-1.3	-0.9	-0.9	-0.4	-0.3	0.5	-0.5	-0.0
Na content in liver	0.1	0.1	0.1	0.4	0.3	-0.3	-0.2	0.2	0.2	0.1	0.2	0.3	-0.3	0.2
Rb content in liver	1.0	1.2	2.3	-1.5	-1.4	1.5	1.4	1.1	1.1	0.7	0.6	-0.7	0.7	0.3
Se content in liver	0.0	0.0	0.2	0.0	-0.1	-0.0	0.2	0.1	0.1	0.3	0.3	-0.1	0.1	0.4
Sr content in liver	3.3	2.8	4.9	2.2	2.0	-2.2	-2.0	-1.6	-1.6	-1.4	-1.3	1.4	-1.4	-1.0
Zn content in liver	1.4	1.5	2.9	1.6	1.4	-1.7	-1.7	-1.1	-1.1	-0.9	-0.7	1.1	-1.1	-0.5
Bone: minimum diameter	3.5	6.4	7.6	-2.3	-2.5	2.3	2.3	2.6	2.6	2.8	2.8	-2.5	2.5	2.7
Time in familiar zone, hab. session 1	0.0	0.0	0.1	0.0	0.0	0.0	0.1	0.4	0.3	0.2	0.2	-0.0	0.0	0.3
Time in novel zone, hab. session 1	0.3	0.3	0.7	-0.8	-0.7	0.8	0.8	0.5	0.6	0.2	0.2	-0.1	0.1	-0.1
Total zone transitions, hab. session 1	0.5	0.7	1.0	0.9	0.9	-0.9	-1.0	-0.8	-0.9	-0.8	-0.8	0.6	-0.6	-0.7
Total locomotion distance, hab. session 1	0.2	0.3	0.5	-0.2	-0.4	0.2	0.6	0.7	0.7	0.6	0.6	-0.1	0.1	0.7
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.5	0.3	-0.5	-0.2	0.0	0.0	0.0	0.0	0.4	-0.4	0.2
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.3	-0.1	0.3	0.2	-0.0	-0.0	-0.3	-0.3	0.1	-0.1	-0.5
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	0.2	-0.4	-0.3	0.1	0.2	0.2	0.3	-0.1	0.1	0.4
Total zone transitions, hab. session 2	0.3	0.4	1.1	1.0	0.9	-1.0	-1.1	-0.3	-0.4	-0.4	-0.2	0.5	-0.5	-0.1
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.2	0.1	-0.2	0.0	0.4	0.4	0.3	0.3	0.0	-0.0	0.4
Locomotion velocity, hab. session 2	0.1	0.2	0.5	-0.0	-0.2	0.0	0.3	0.7	0.6	0.5	0.5	-0.2	0.2	0.6
Novel to familiar place preference ratio	0.4	0.4	1.5	0.8	0.6	-0.9	-1.2	-0.7	-0.7	-0.2	-0.1	0.0	-0.0	0.1
Novelty place preference	0.2	0.2	0.8	0.5	0.4	-0.6	-0.9	-0.5	-0.5	-0.0	-0.0	-0.1	0.1	0.2
Time in novel zone, NPP test	0.2	0.2	0.8	0.7	0.5	-0.8	-0.9	-0.5	-0.5	-0.1	-0.1	-0.0	0.0	0.1
Total zone transitions, NPP test	1.2	1.7	2.7	1.6	1.5	-1.6	-1.7	-1.2	-1.2	-1.2	-1.1	1.1	-1.1	-0.9
Total locomotion distance, NPP test	0.1	0.1	0.3	0.4	0.4	-0.5	-0.5	-0.2	-0.2	-0.3	-0.2	0.3	-0.3	-0.2
Locomotion velocity, NPP test	0.1	0.1	0.4	0.3	0.4	-0.4	-0.6	-0.3	-0.4	-0.4	-0.3	0.2	-0.2	-0.3
Intraocular pressure	0.3	0.4	0.8	0.4	0.5	-0.4	-0.1	-0.4	-0.6	-0.8	-0.9	0.8	-0.8	-0.9
Delta distance traveled before/after self-admin	0.3	0.3	1.0	0.0	0.2	-0.1	-0.0	-0.4	-0.6	-0.8	-0.9	0.2	-0.2	-1.0
Delta ambulatory time before/after self-admin	0.3	0.4	1.3	-0.0	0.2	-0.1	-0.0	-0.4	-0.7	-0.9	-1.0	0.4	-0.4	-1.1
Parametrial fat weight	6.0	14.1	20.8	-3.7	-3.9	3.7	3.2	2.9	3.0	3.9	3.8	-4.6	4.6	3.6
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.4	-0.3	0.3	0.5	-0.1	-0.1	-0.3	-0.4	0.0	-0.0	-0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	0.5	0.3	-0.3	-0.1	0.4	0.3	0.5	0.6	0.2	-0.2	0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	0.3	-0.3	-0.1	0.2	0.2	0.2	0.3	0.2	-0.2	0.4
Pavlov. Cond. index score	0.1	0.1	0.3	0.6	0.5	-0.5	-0.5	-0.1	-0.1	-0.0	0.1	0.4	-0.4	0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	0.3	-0.2	-0.3	0.2	0.2	0.2	0.4	0.2	-0.2	0.5
Pavlov. Cond. lever contacts	0.1	0.1	0.4	0.0	-0.0	0.0	-0.2	0.4	0.4	0.5	0.6	-0.2	0.2	0.7
Pavlov. Cond. magazine entry number	0.4	0.4	0.9	-0.9	-0.9	0.8	0.7	0.5	0.6	0.4	0.3	-0.8	0.8	0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.7	0.8	0.6	0.8	-0.6	-0.8	-0.9	-0.9	-0.9	-0.8	0.8	-0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	0.6	0.6	-0.6	-0.5	-0.1	-0.2	-0.1	0.1	0.5	-0.5	0.2
Pavlov. Cond. response bias	0.2	0.2	0.6	0.8	0.7	-0.7	-0.6	-0.2	-0.3	-0.1	0.0	0.6	-0.6	0.2
Pavlov. Cond. lever latency	0.1	0.2	0.5	-0.5	-0.3	0.4	-0.2	-0.4	-0.4	-0.4	-0.5	-0.4	0.4	-0.7
Pavlov. Cond. magazine entry latency	2.6	3.1	6.5	2.6	2.2	-2.4	-1.7	-1.2	-1.1	-1.0	-0.8	2.2	-2.2	-0.4
Pavlov. Cond. change in total contacts	0.4	0.6	1.4	1.2	1.0	-1.0	-0.3	0.0	0.1	0.0	0.2	1.2	-1.2	0.4
Pavlov. Cond. index score	0.8	1.0	2.7	1.6	1.3	-1.4	-0.7	-0.3	-0.2	-0.1	0.0	1.4	-1.4	0.4
Pavlov. Cond. latency score	0.6	0.8	2.2	1.5	1.1	-1.3	-0.6	-0.2	-0.1	0.1	0.2	1.2	-1.2	0.6
Pavlov. Cond. lever contacts	0.2	0.3	0.7	0.7	0.5	-0.6	0.1	0.3	0.3	0.2	0.2	0.8	-0.8	0.4
Pavlov. Cond. magazine entry number	3.7	4.6	9.6	-3.1	-2.7	2.9	2.1	1.5	1.4	1.2	1.1	-2.6	2.6	0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.3	-1.2	-0.9	1.1	0.8	0.3	0.4	0.3	0.3	-0.9	0.9	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	3.3	1.8	1.5	-1.6	-0.8	-0.4	-0.4	-0.3	-0.1	1.6	-1.6	0.3
Pavlov. Cond. response bias	0.5	0.7	1.9	1.4	1.1	-1.2	-0.5	-0.1	-0.1	-0.1	0.0	1.2	-1.2	0.4
Time in closed arm before self-admin	0.6	0.8	1.3	-0.8	-0.8	0.9	0.8	1.0	1.0	1.1	1.1	-0.6	0.6	1.1
Time in closed arm after self-admin	0.5	0.5	0.8	-0.9	-0.8	0.8	0.6	0.9	0.8	0.5	0.4	-0.7	0.7	0.3
Time in open arm before self-admin	0.2	0.2	0.7	-0.6	-0.5	0.4	-0.1	-0.2	-0.1	-0.5	-0.5	-0.5	0.5	-0.8
Time in open arm after self-admin	1.1	1.3	2.2	1.0	1.1	-1.1	-1.1	-1.5	-1.3	-1.2	-1.2	0.8	-0.8	-1.1
Bone: periosteal estimation	1.7	3.5	4.9	-1.5	-1.7	1.6	1.4	1.8	1.8	2.1	2.2	-2.0	2.0	2.2
Bone: periosteal perimeter	0.9	1.6	2.5	-1.0	-1.1	1.1	1.0	1.4	1.4	1.5	1.6	-1.1	1.1	1.6
Bone: post-yield work	4.5	6.5	9.7	-2.1	-2.3	2.1	2.0	2.5	2.5	3.0	3.1	-2.6	2.6	3.1
Progressive ratio test 1 active lever presses	0.6	0.8	1.0	-0.7	-0.8	0.8	0.8	1.0	1.0	1.0	1.0	-0.8	0.8	1.0
Progressive ratio test 1 breakpoint	0.6	0.8	1.0	-0.7	-0.8	0.7	0.9	1.0	1.0	1.0	1.0	-0.8	0.8	1.0
Progressive ratio test 1 inactive lever presses	0.2	0.3	1.1	0.5	0.1	-0.5	-0.0	0.6	0.5	0.7	0.7	-0.0	0.0	1.0
Progressive ratio test 2 active lever presses	2.8	3.2	4.4	-1.5	-1.7	1.6	1.8	2.0	2.1	2.0	2.0	-1.4	1.4	2.0
Progressive ratio test 2 breakpoint	3.0	3.4	4.7	-1.5	-1.7	1.6	1.8	2.1	2.2	2.1	2.1	-1.4	1.4	2.1
Progressive ratio test 2 inactive lever presses	2.0	3.3	5.4	-1.4	-1.6	1.5	1.8	2.3	2.1	2.1	2.1	-1.2	1.2	2.2
Incentive Sensitization - Responses	0.6	0.9	2.4	-0.2	-0.5	0.3	0.6	1.1	1.1	1.3	1.4	-0.6	0.6	1.5
Incentive Sensitization - Breakpoint	1.0	1.3	3.2	-0.4	-0.7	0.5	0.8	1.3	1.4	1.5	1.6	-0.8	0.8	1.8
Sum of active levers in priming session hrs 5-6	1.8	1.7	2.2	1.4	1.5	-1.3	-1.1	-1.2	-1.4	-1.2	-1.2	1.4	-1.4	-1.1
Progressive ratio	0.8	1.3	2.2	-0.8	-0.9	0.8	1.0	1.5	1.2	1.3	1.3	-0.8	0.8	1.4
Food seeking constrained by brief footshock	0.0	0.1	0.2	-0.2	-0.2	0.2	0.2	0.4	0.4	0.1	0.1	0.2	-0.2	0.1
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	0.3	0.4	-0.4	-0.6	-0.7	-0.5	-0.7	-0.7	0.3	-0.3	-0.8
Retroperitoneal fat weight	4.9	20.7	25.8	-5.0	-5.0	5.0	4.7	3.9	4.0	4.3	4.0	-5.1	5.1	3.6
Reaction time number correct	0.3	0.6	0.9	0.8	0.9	-0.8	-0.9	-0.6	-0.6	-0.8	-0.7	1.0	-1.0	-0.7
Reaction time mean minus median	0.7	1.8	3.2	1.4	1.4	-1.3	-0.9	-1.3	-1.3	-1.1	-1.1	1.8	-1.8	-1.0
Reaction time mean minus median AUC	1.2	2.9	5.1	1.5	1.6	-1.4	-1.0	-1.6	-1.6	-1.7	-1.7	2.3	-2.3	-1.7
Reaction time num false alarms	0.2	0.2	0.7	-0.1	0.1	-0.0	-0.4	-0.6	-0.5	-0.6	-0.7	-0.3	0.3	-0.8
Reaction time num false alarms AUC	0.5	0.9	1.7	0.5	0.6	-0.6	-1.1	-1.3	-1.1	-1.1	-1.2	-0.1	0.1	-1.3
Reaction time trials correct on left	0.3	0.6	0.9	0.8	0.9	-0.8	-0.9	-0.6	-0.6	-0.8	-0.7	1.0	-1.0	-0.7
Reaction time trials on left	0.4	0.8	1.1	0.9	1.0	-0.9	-1.0	-0.7	-0.7	-0.9	-0.8	1.1	-1.1	-0.8
Reaction time mean	0.4	0.7	2.2	0.8	0.8	-0.6	-0.0	-0.3	-0.4	-0.7	-0.7	1.5	-1.5	-0.6
Reaction time mean AUC	0.3	0.4	1.7	0.5	0.5	-0.3	0.3	-0.1	-0.0	-0.4	-0.4	1.3	-1.3	-0.4
Median of all reaction times	0.2	0.2	0.9	0.5	0.5	-0.4	0.2	0.1	0.0	-0.2	-0.2	1.0	-1.0	-0.2
Reaction time omissions	1.0	1.5	1.8	1.2	1.3	-1.1	-1.1	-1.3	-1.3	-1.3	-1.3	1.2	-1.2	-1.2
Reaction time false alarm rate	0.2	0.2	0.8	-0.3	-0.2	0.2	-0.2	-0.5	-0.3	-0.2	-0.3	-0.9	0.9	-0.4
Reaction time premature initiation rate	0.4	0.5	1.4	0.8	0.5	-0.9	-1.2	-0.2	-0.1	0.5	0.7	-0.5	0.5	1.0
Reaction time premature initiations	0.7	1.3	4.1	1.6	1.4	-1.7	-2.0	-1.1	-0.9	-0.5	-0.3	0.6	-0.6	0.0
Std. dev. reaction times	0.9	1.7	3.5	1.0	1.2	-0.9	-0.5	-1.2	-1.2	-1.3	-1.4	1.9	-1.9	-1.4
Reaction time trials completed	0.4	0.8	1.1	0.9	1.0	-0.9	-1.0	-0.7	-0.7	-0.9	-0.8	1.1	-1.1	-0.8
Reaction time trials AUC	0.3	0.5	0.8	0.7	0.8	-0.7	-0.8	-0.5	-0.5	-0.7	-0.6	0.9	-0.9	-0.7
Run reversals in cocaine runway, females	0.9	0.9	1.8	-0.6	-0.8	0.5	0.2	0.7	0.7	1.1	1.1	-1.3	1.3	1.2
Run reversals in cocaine runway, males	0.3	0.3	1.0	-0.8	-0.6	0.7	0.2	-0.2	-0.1	0.1	0.1	-1.0	1.0	-0.1
Latency to leave start box in cocaine runway	3.2	3.6	4.2	-1.8	-1.9	1.8	1.5	2.0	1.8	2.0	2.1	-2.0	2.0	2.0
Latency to leave start box in cocaine runway, F	0.7	0.8	1.3	-0.6	-0.8	0.6	0.4	1.0	0.7	1.0	1.1	-1.1	1.1	1.1
Latency to leave start box in cocaine runway, M	3.0	2.8	3.7	-1.9	-1.9	1.9	1.7	1.7	1.6	1.5	1.4	-1.6	1.6	1.3
Std. dev. time between licks in bursts	0.1	0.2	0.3	-0.5	-0.5	0.4	0.3	0.4	0.4	0.2	0.2	-0.5	0.5	0.1
Total sessions with >9 infusions	0.6	0.7	1.1	-0.7	-0.8	0.7	1.0	1.1	1.0	0.8	0.7	-0.6	0.6	0.7
Short access day 1 total inactive lever presses	0.4	0.6	1.0	-0.6	-0.7	0.5	0.5	1.0	0.6	0.8	0.8	-0.9	0.9	0.8
Short access day 10 total inactive lever presses	0.1	0.3	0.7	0.1	0.2	-0.1	0.3	0.1	-0.1	-0.6	-0.7	0.8	-0.8	-0.8
Short access day 1 total infusions	1.0	1.3	1.9	-1.2	-1.3	1.2	1.3	1.4	1.2	1.0	1.0	-1.1	1.1	0.9
Short access day 10 total infusions	3.4	4.3	6.5	-1.5	-1.8	1.5	1.8	2.6	2.4	2.4	2.4	-1.8	1.8	2.5
Short access total infusions	2.3	2.9	4.0	-1.4	-1.6	1.3	1.5	2.0	1.9	1.8	1.8	-1.7	1.7	1.8
Short access day 1 locomotion	0.2	0.2	0.2	-0.5	-0.5	0.5	0.5	0.4	0.4	0.5	0.5	-0.5	0.5	0.5
Short access day 10 total locomotion	1.2	2.2	4.1	-0.7	-1.1	0.8	1.4	1.9	2.0	1.8	1.8	-0.7	0.7	2.0
Short access total locomotion	1.4	1.7	3.0	-0.8	-1.1	0.8	1.3	1.5	1.7	1.6	1.6	-0.9	0.9	1.7
One hour access (0.3 mA shock)	3.8	4.4	6.6	-1.8	-2.0	1.9	2.0	2.6	2.2	2.3	2.3	-1.9	1.9	2.2
Compulsive drug intake	2.7	3.2	4.2	1.6	1.7	-1.7	-1.6	-2.0	-1.8	-2.0	-2.1	1.6	-1.6	-2.0
One hour access (shock baseline)	5.3	8.1	10.8	-2.8	-2.8	2.9	2.8	3.3	2.9	2.9	2.9	-2.5	2.5	2.7
Social response proportion	0.1	0.1	0.1	-0.3	-0.2	0.3	-0.3	0.1	0.1	0.2	0.3	-0.4	0.4	0.1
Social responses	0.6	0.7	1.3	0.4	0.7	-0.4	-1.0	-1.1	-0.9	-1.1	-1.0	0.7	-0.7	-1.2
Social time	1.5	2.0	3.5	1.0	1.2	-1.0	-1.1	-1.4	-1.3	-1.7	-1.7	1.5	-1.5	-1.9
Soleus weight	1.0	2.8	5.8	-2.4	-2.0	2.4	2.4	1.6	1.6	1.0	0.9	-1.0	1.0	0.4
Bone: stiffness	0.1	0.2	0.6	0.0	-0.0	0.0	-0.1	0.3	0.3	0.6	0.7	-0.3	0.3	0.8
Tibialis anterior weight	4.7	15.8	28.3	5.2	4.8	-5.3	-5.3	-3.9	-3.9	-3.1	-2.8	2.8	-2.8	-1.9
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.5	-0.5	-0.6	0.4	0.4	1.0	0.9	1.1	1.1	-0.9	0.9	1.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	0.2	-0.0	-0.2	-0.1	0.4	0.4	0.5	0.5	-0.3	0.3	0.7
Time to tail flick, test, before self-admin	1.1	1.2	2.3	-0.8	-1.0	0.7	0.3	0.9	0.9	1.2	1.2	-1.5	1.5	1.3
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.2	0.3	-0.1	-0.1	-0.4	-0.3	-0.3	-0.3	0.5	-0.5	-0.3
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	0.8	0.7	-0.8	-0.6	-0.5	-0.5	-0.6	-0.6	0.7	-0.7	-0.5
Delta time to tail flick, test, before/after SA	2.7	2.8	4.5	1.3	1.6	-1.2	-0.9	-1.8	-1.6	-1.7	-1.7	2.1	-2.1	-1.8
Tibia length	0.2	0.6	1.6	1.2	1.0	-1.1	-1.3	-0.7	-0.7	-0.1	0.1	0.4	-0.4	0.4
Ambulatory time before self-admin	0.2	0.3	0.7	0.8	0.7	-0.7	-0.6	-0.3	-0.0	0.1	0.3	0.6	-0.6	0.5
Ambulatory time after self-admin	0.0	0.0	0.1	0.1	0.1	-0.1	0.0	0.1	0.2	0.2	0.3	0.2	-0.2	0.4
Bone: tissue strength	0.2	0.2	0.5	-0.7	-0.6	0.7	0.6	0.5	0.5	0.2	0.2	-0.1	0.1	0.0
Total heroin consumption	7.7	9.0	11.0	3.3	3.3	-3.3	-3.3	-3.1	-3.3	-2.8	-2.8	2.6	-2.6	-2.4
Bone: trabecular number	0.1	0.2	0.9	0.2	-0.0	-0.2	-0.2	0.4	0.3	0.7	0.8	-0.4	0.4	1.0
Bone: trabecular spacing	0.6	0.9	1.9	0.4	0.6	-0.4	-0.2	-0.5	-0.5	-1.2	-1.2	1.3	-1.3	-1.4
Bone: trabecular thickness	0.5	0.6	0.8	-0.9	-0.9	0.9	0.9	0.7	0.7	0.9	0.8	-0.7	0.7	0.8
Bone: trabecular tissue density	0.8	1.2	3.1	-1.7	-1.4	1.8	1.7	0.7	0.7	0.3	0.1	-0.8	0.8	-0.3
Water consumed over 24 hours	0.5	0.6	1.1	0.8	0.8	-0.8	-1.0	-1.0	-0.9	-0.8	-0.7	0.6	-0.6	-0.6
Number of responses in last shaping day	0.9	1.0	1.4	1.1	1.0	-1.1	-1.2	-0.9	-1.1	-1.0	-1.0	0.7	-0.7	-0.9