Fen1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	NM_053430.3	0.03	0.02	4.9e-03	0.03	0.03	0.03	0.03	1.4e-03	2.1e-03	1.6e-03	1.5e-03
2	BLA	intron excision ratio	chr1_206847068_206849266	0.1	0.07	1.4e-04	0.03	0.04	0.04	0.03	1.6e-02	3.5e-03	4.5e-03	1.3e-02
3	Brain	gene expression	Fen1	0.03	0.02	3.6e-03	0.02	0.02	0.01	0.01	3.7e-03	1.1e-02	1.9e-02	6.2e-02
4	BLA	isoform ratio	NM_053430.3	0.07	0.06	4.8e-03	0.03	0.01	-0	0.02	1.3e-02	1.1e-01	3.9e-01	4.1e-02
5	BLA	alternative TSS	NM_053430.3	0.07	0.06	6.7e-03	0.02	0	-0	0	3.6e-02	2.9e-01	5.4e-01	1.7e-01
6	BLA	gene expression	Fen1	0.07	0.05	8.5e-03	0.03	0.03	0.01	0.02	6.5e-03	9.7e-03	5.8e-02	2.0e-02
7	Brain	alternative TSS	XM_039092823.1	0.06	0.04	1.2e-03	0.02	0.02	0.01	0.01	2.3e-03	7.1e-03	1.4e-02	1.3e-02
8	NAcc	gene expression	Fen1	0.05	0.04	6.0e-04	0.01	0.01	0.01	0.01	9.0e-03	3.4e-02	2.2e-02	5.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.3	0.5	0.9	-0.4	-0.3	-0.6	0.6	0.6	-0.8	-1.0	-0.9
Area under the delay curve	1.0	1.0	2.1	-0.2	-0.6	-0.5	1.4	1.4	-0.8	-1.3	-1.1
BMI with tail	0.5	1.7	6.6	-2.6	0.7	-1.2	0.9	0.9	-1.5	-0.8	-0.8
BMI without tail	0.3	0.5	2.1	-1.5	0.9	0.1	-0.4	-0.4	-0.0	0.7	0.6
Body weight	0.6	2.4	14.4	-3.8	2.0	0.8	0.2	0.2	0.3	0.1	0.4
Weight adjusted by age	1.9	2.1	3.2	-1.6	1.7	0.5	-1.8	-1.8	0.8	1.5	1.5
Bone surface	0.4	0.8	2.6	-1.6	0.2	-0.1	0.7	0.7	-0.5	-1.2	-1.0
Bone volume	0.4	0.7	1.5	-0.9	-0.3	-0.5	0.8	0.8	-0.8	-1.2	-1.1
Breakpoint value in progressive ratio session	3.6	4.0	5.1	-1.7	2.3	2.1	-2.1	-2.1	1.8	1.9	1.9
Number of licking bursts	0.2	0.2	0.5	0.1	-0.3	-0.1	0.7	0.7	-0.3	-0.5	-0.4
Context. condit. distance diff. score	0.1	0.1	0.4	0.4	-0.3	-0.6	0.1	0.1	-0.2	0.1	0.1
Locomotion velocity, session 1	0.2	0.2	0.4	-0.2	0.4	-0.2	-0.6	-0.6	0.3	0.6	0.4
Locomotion distance, session 1	0.3	0.4	0.9	-1.0	0.8	-0.2	-0.5	-0.5	0.7	0.6	0.5
Locomotion velocity, session 2	0.9	1.0	4.0	-2.0	1.4	0.6	-0.7	-0.7	0.6	0.6	0.4
Locomotion distance, session 2	0.4	0.5	0.9	-0.6	0.9	0.3	-0.6	-0.6	0.8	0.9	0.7
Locomotion velocity, session 3	1.1	1.3	2.4	-0.6	-0.6	-1.3	1.5	1.5	-0.7	-1.2	-1.1
Locomotion distance, session 3	0.2	0.2	0.5	-0.1	-0.4	-0.4	0.7	0.7	0.1	-0.6	-0.4
Stereotopy head waving bouts, day 3	1.1	1.3	2.1	0.1	-0.8	-1.2	1.4	1.4	-1.2	-1.2	-1.2
Stereotopy head waving duration, day 3	0.4	0.5	1.1	0.2	-0.5	-0.7	1.0	1.0	-0.7	-0.5	-0.6
Locomotion velocity, session 7	0.8	0.8	1.9	0.0	-0.6	-0.4	1.4	1.4	-0.3	-1.0	-1.1
Locomotion distance, session 7	0.4	0.5	1.2	0.3	-0.6	-0.6	1.1	1.1	-0.4	-0.5	-0.6
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	-0.6	0.2	-0.1	0.0	0.0	-0.0	-0.3	-0.4
Stereotopy head waving duration, day 7	0.5	0.7	3.0	-1.7	1.1	0.7	-0.3	-0.3	0.6	0.2	0.2
Locomotion velocity, session 8	0.2	0.2	0.3	-0.1	0.4	0.6	-0.2	-0.2	0.6	0.5	0.5
Locomotion distance, session 8	0.2	0.3	0.8	0.4	-0.4	-0.9	0.6	0.6	-0.5	-0.4	-0.5
Degree of sensitization distance	0.6	0.6	1.6	0.2	-0.4	-1.0	0.7	0.7	-1.3	-0.5	-0.9
Degree of sensitization stereotypy	0.5	0.5	1.7	-1.3	0.9	0.5	-0.8	-0.8	0.4	0.2	0.2
Conditioned locomotion	0.2	0.3	0.7	-0.9	0.7	0.5	-0.0	-0.0	0.6	0.3	0.4
Cocaine response after cond. corrected	0.2	0.2	0.6	0.8	-0.3	-0.8	-0.2	-0.2	-0.2	0.3	0.2
Cocaine response after cond. not corrected	0.2	0.3	0.9	0.7	-0.4	-0.9	-0.4	-0.4	-0.5	0.1	-0.1
Cocaine response before conditioning	0.2	0.2	0.7	-0.7	0.3	0.2	-0.8	-0.8	-0.1	-0.2	-0.2
Saline control response	1.8	2.3	3.3	-1.8	1.8	1.4	-1.4	-1.4	1.5	1.3	1.5
Bone: connectivity density	0.3	0.4	2.3	-1.5	0.5	-0.1	0.1	0.1	-0.4	-0.6	-0.4
Bone: cortical apparent density	0.9	1.2	1.6	-0.8	1.1	1.2	-1.3	-1.3	1.1	0.8	0.9
Bone: cortical area	0.1	0.2	1.4	-1.2	0.4	0.2	0.0	0.0	0.3	-0.2	-0.2
Bone: cortical porosity	0.4	0.5	1.3	-0.1	0.5	0.9	-0.3	-0.3	1.1	0.7	0.9
Bone: cortical porosity	0.9	1.0	2.3	-0.3	1.0	1.3	-0.6	-0.6	1.5	1.0	1.1
Bone: cortical thickness	2.9	4.8	6.5	-2.4	2.5	2.4	-1.8	-1.8	2.5	1.9	2.0
Bone: cortical thickness	1.1	1.3	1.9	-0.7	0.9	1.1	-1.2	-1.2	1.4	1.2	1.0
Bone: cortical tissue density	1.1	1.5	2.0	-0.9	1.3	1.3	-1.4	-1.4	1.2	0.9	1.0
Condit. Reinf. active minus inactive responses	1.0	1.1	1.9	-1.1	1.2	0.2	-1.4	-1.4	0.7	1.0	0.8
Condit. Reinf. active-inactive response ratio	2.1	2.2	4.1	-0.7	1.4	0.7	-2.0	-2.0	1.1	1.8	1.5
Condit. Reinf. active responses	0.3	0.4	1.2	-1.1	0.8	-0.3	-0.8	-0.8	0.1	0.3	0.2
Condit. Reinf. inactive responses	0.8	0.9	1.9	0.0	-0.7	-1.4	0.8	0.8	-1.1	-1.2	-1.1
Incentive salience index mean	0.3	0.3	1.5	-1.2	0.7	-0.2	-0.5	-0.5	0.1	0.1	0.0
Condit. Reinf. lever presses	0.5	0.6	1.4	-0.8	-0.2	-0.7	0.8	0.8	-0.6	-1.2	-1.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.2	-0.3	-0.4	-0.4	-0.3	-0.0	-0.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.6	0.5	-0.7	-0.9	0.2	0.2	-1.3	-0.6	-0.8
Condit. Reinf. active responses	0.0	0.1	0.2	-0.1	0.1	-0.1	-0.4	-0.4	0.0	0.2	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.3	0.2	0.2	-0.3	-0.3	0.6	0.3	0.5
Condit. Reinf. lever presses	0.2	0.3	1.2	-1.1	0.5	-0.1	-0.5	-0.5	-0.3	0.2	0.1
Condit. Reinf. lever reinforcers received	0.2	0.3	0.7	-0.5	0.5	0.2	-0.8	-0.8	0.3	0.5	0.5
Conditioned reinforcement - actives	0.5	0.5	1.8	1.3	-0.8	-0.9	-0.3	-0.3	-0.4	-0.1	-0.1
Conditioned reinforcement - inactives	0.9	1.1	2.1	0.8	-1.2	-1.4	0.6	0.6	-1.3	-1.0	-1.0
Conditioned locomotion	1.9	2.2	3.2	1.3	-1.8	-1.8	1.3	1.3	-1.7	-1.4	-1.4
Patch foraging indifference point 0 sec	0.2	0.3	1.1	-1.0	0.7	0.7	0.1	0.1	0.3	0.1	0.1
Patch foraging indifference point AUC	1.0	1.2	3.5	-1.9	1.4	1.2	-0.9	-0.9	0.5	0.5	0.6
Delay disc. indifference point, 0s delay	1.7	1.9	2.9	0.3	-1.2	-1.5	1.7	1.7	-1.6	-1.3	-1.3
Delay disc. indifference point, 16s delay	0.3	0.3	0.7	-0.3	-0.2	-0.6	0.6	0.6	-0.6	-0.8	-0.7
Delay disc. indifference point, 2s delay	2.3	2.6	3.7	0.3	-1.3	-1.4	1.8	1.8	-1.7	-1.9	-1.9
Delay disc. indifference point, 24s delay	0.2	0.1	0.4	-0.2	-0.2	0.0	0.6	0.6	-0.2	-0.4	-0.3
Delay disc. indifference point, 4s delay	1.1	1.1	2.9	-0.4	-0.5	-0.3	1.7	1.7	-0.5	-1.1	-1.1
Delay disc. indifference point, 8s delay	1.0	1.0	2.5	0.6	-0.8	-0.1	1.6	1.6	-0.5	-1.1	-0.9
Indifference point function ln k	2.7	3.7	6.6	2.5	-2.4	-2.6	1.6	1.6	-1.6	-1.2	-1.3
Indifference point function log k	2.7	3.7	6.6	2.5	-2.4	-2.6	1.6	1.6	-1.6	-1.2	-1.3
Patch foraging total patch changes 0 sec	0.3	0.4	1.0	-1.0	0.8	0.9	-0.2	-0.2	0.6	0.3	0.4
Patch foraging total patch changes 12 sec	4.5	5.8	10.9	-3.3	3.0	2.8	-1.8	-1.8	2.0	1.9	2.1
Patch foraging total patch changes 18 sec	0.5	0.7	1.6	-1.1	1.0	1.2	-0.4	-0.4	0.7	0.5	0.6
Patch foraging total patch changes 24 sec	2.2	2.7	10.5	-3.2	2.2	1.8	-0.4	-0.4	1.1	0.8	0.8
Patch foraging total patch changes 6 sec	0.3	0.4	2.2	-1.5	0.7	0.8	0.3	0.3	0.1	-0.0	-0.0
Patch foraging time to switch 0 sec	0.3	0.4	0.7	-0.9	-0.0	-0.5	0.8	0.8	-0.6	-0.7	-0.6
Patch foraging water rate 0 sec	0.1	0.2	0.9	0.9	-0.4	0.0	-0.4	-0.4	0.2	0.1	0.1
Patch foraging water rate 12 sec	0.5	0.8	3.2	1.8	-1.2	-1.0	0.2	0.2	-0.7	0.0	-0.3
Patch foraging water rate 18 sec	0.4	0.6	1.2	1.1	-1.1	-1.0	0.5	0.5	-0.7	-0.2	-0.3
Patch foraging water rate 24 sec	0.4	0.5	2.2	1.5	-1.0	-0.8	0.0	0.0	-0.3	0.2	-0.0
Patch foraging water rate 6 sec	0.3	0.4	1.9	1.4	-0.9	-0.5	0.4	0.4	-0.0	0.0	-0.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.6	0.0	-0.4	-0.5	0.8	0.8	-0.3	-0.6	-0.5
Distance traveled before self-admin	1.1	1.1	3.0	-1.7	1.3	0.8	-1.1	-1.1	0.8	0.6	0.6
Distance traveled after self-admin	0.1	0.1	0.3	-0.6	0.4	0.6	-0.4	-0.4	0.2	0.1	0.1
Extensor digitorum longus weight	1.8	7.1	24.5	-5.0	3.7	2.1	-1.5	-1.5	2.1	1.5	1.8
Bone: elastic displacement	0.6	0.6	1.0	0.9	0.2	0.6	-0.9	-0.9	0.8	1.0	0.8
Bone: elastic work	1.5	1.9	2.6	-0.8	1.4	1.3	-1.3	-1.3	1.6	1.4	1.6
Bone: endosteal estimation	3.7	8.0	10.4	1.7	-2.9	-3.2	2.9	2.9	-3.2	-2.8	-2.8
Bone: endosteal perimeter	4.8	10.0	12.2	2.0	-3.3	-3.4	3.2	3.2	-3.5	-3.2	-3.3
Epididymis fat weight	1.7	4.0	4.8	1.1	-2.0	-2.0	2.2	2.2	-2.0	-2.1	-2.1
Delta time in closed arm before/after self-admin	1.5	1.4	2.2	-1.3	1.5	0.9	-0.5	-0.5	1.4	1.4	1.4
Delta time in open arm before/after self-admin	1.2	1.2	1.7	-1.3	1.3	0.9	-1.3	-1.3	0.9	0.8	0.8
Diff in mean of infusions in LGA sessions	3.0	3.3	4.3	-1.4	2.1	2.0	-1.8	-1.8	2.0	1.7	1.7
Delay discount exponential model param	1.1	1.1	2.2	0.1	0.7	0.5	-1.5	-1.5	0.9	1.3	1.2
Extinction: sum of active levers before priming	1.6	1.6	3.9	-2.0	1.7	1.0	-1.0	-1.0	1.2	0.9	0.9
Active lever presses in extinction session 6	2.8	2.7	3.6	-1.7	1.9	1.6	-1.7	-1.7	1.8	1.2	1.2
Bone: final force	0.4	0.6	3.0	-1.7	1.0	0.2	-0.4	-0.4	0.2	0.3	0.4
Bone: final moment	0.3	0.5	2.9	-1.7	1.0	0.3	-0.4	-0.4	0.2	0.3	0.3
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.3	-0.2	-0.2	-0.5	-0.5	0.1	0.2	0.1
Glucose	3.9	5.8	7.6	2.3	-2.6	-2.3	2.3	2.3	-2.8	-2.2	-2.3
Heart weight	1.2	1.6	2.7	1.2	-1.3	-1.1	1.6	1.6	-1.3	-0.8	-1.0
Delay discount hyperbolic model param	1.3	1.3	2.5	0.2	0.7	0.6	-1.6	-1.6	1.0	1.4	1.3
Intermittent access intake day 1-15 change	0.2	0.2	0.9	0.9	-0.3	-0.1	-0.6	-0.6	0.3	0.1	0.1
Intermittent access intake escalation	0.2	0.2	0.5	0.7	-0.1	-0.0	-0.7	-0.7	0.3	0.3	0.2
Intermittent access intake escalation 2	0.5	0.5	1.1	-0.1	0.5	0.6	-1.0	-1.0	0.8	0.5	0.5
Intermitt. access day 1 inactive lever presses	2.7	2.9	6.1	1.0	-1.7	-1.9	1.4	1.4	-2.5	-1.6	-1.6
Intermitt. access day 15 inactive lever presses	2.0	2.2	4.2	-0.4	-1.0	-1.8	1.3	1.3	-2.1	-1.7	-1.7
Intermitt. access escalation Index	2.2	1.9	3.2	0.5	-1.1	-1.4	1.8	1.8	-1.3	-1.4	-1.3
Intermittent access day 1 total infusions	5.1	5.9	9.7	0.7	-2.2	-3.1	2.5	2.5	-2.7	-2.5	-2.5
Intermittent access day 15 total infusions	3.6	4.0	7.4	1.6	-2.2	-2.7	1.6	1.6	-2.0	-2.0	-2.0
Intermittent access terminal intake (last 3 days)	1.8	1.9	5.3	0.5	-1.3	-2.3	1.0	1.0	-1.5	-1.5	-1.4
Intermittent access total infusions	2.7	3.0	5.8	0.7	-1.7	-2.4	1.6	1.6	-1.9	-1.9	-1.8
Intermittent access day 1 locomotion	3.7	3.9	5.9	0.1	-1.6	-2.4	2.2	2.2	-2.3	-2.0	-1.9
Intermittent access day 15 total locomotion	1.1	1.2	2.7	0.0	-0.9	-1.6	0.9	0.9	-1.4	-1.2	-1.1
Intermittent access total locomotion	4.3	4.9	8.1	-0.0	-1.8	-2.8	2.1	2.1	-2.7	-2.5	-2.4
Intermittent access standard deviation	1.1	1.2	2.3	0.9	0.2	0.1	-1.5	-1.5	0.9	1.2	1.2
Left kidney weight	0.7	2.1	3.8	-0.1	-0.9	-0.8	1.9	1.9	-1.6	-1.6	-1.5
Right kidney weight	0.4	1.1	1.9	-0.4	-0.5	-0.6	1.4	1.4	-1.3	-1.2	-1.1
Cocaine induced anxiety	0.4	0.4	0.8	-0.6	0.7	0.0	-0.9	-0.9	0.2	0.7	0.6
Post-drug Anxiety	0.6	0.7	1.4	-0.9	0.9	0.2	-1.2	-1.2	0.3	0.8	0.7
Baseline Anxiety	0.7	0.7	1.2	-1.0	1.0	1.1	-0.7	-0.7	0.8	0.7	0.7
Tail length	1.2	3.5	4.7	-1.6	2.0	2.2	-1.5	-1.5	2.1	1.9	2.1
Length with tail	0.6	2.2	8.1	-2.8	1.9	1.6	-0.3	-0.3	1.5	0.6	0.9
Length without tail	0.3	0.7	3.6	-1.9	0.8	0.4	0.6	0.6	0.2	-0.6	-0.4
Times rat made contact with spout	1.0	1.2	2.0	-0.3	0.9	0.9	-1.2	-1.2	1.2	1.3	1.4
Lifetime Intake	2.2	2.4	5.1	0.7	-1.5	-2.3	1.5	1.5	-1.7	-1.5	-1.5
Liver weight, left	0.4	0.6	1.0	0.9	-0.8	-0.3	1.0	1.0	-0.5	-0.7	-0.5
Liver weight, right	0.3	0.5	0.7	0.2	-0.5	-0.9	0.8	0.8	-0.5	-0.7	-0.6
Locomotor activity	0.2	0.3	1.3	1.1	-0.5	0.1	0.5	0.5	0.2	-0.1	-0.2
Locomotor testing distance	0.2	0.4	1.4	1.2	-0.7	-0.3	0.6	0.6	-0.4	-0.2	-0.5
Locomotor testing rearing	0.2	0.3	1.5	1.2	-0.6	-0.5	-0.0	-0.0	-0.3	0.3	0.0
Locomotion in novel chamber	2.8	3.4	5.5	1.4	-2.0	-2.4	1.4	1.4	-2.0	-2.0	-2.1
Locomotion in novel chamber post-restriction	0.4	0.4	2.7	1.6	-0.7	-0.4	-0.0	-0.0	-0.1	0.2	-0.0
Fecal boli incidents, locomotor time 1	0.2	0.2	0.5	0.3	-0.1	-0.4	-0.7	-0.7	-0.4	0.1	0.0
Change in fecal boli incidents, locomotor task	1.8	1.7	2.9	1.1	-1.4	-1.1	1.7	1.7	-1.3	-1.0	-0.9
Time >=10cm from walls, locomotor time 1	2.3	2.3	4.0	1.4	-1.7	-2.0	1.0	1.0	-1.7	-1.5	-1.4
Bouts of movement, locomotor time 1	4.4	4.8	6.1	-0.6	2.0	2.3	-2.5	-2.5	2.4	2.3	2.2
Total resting periods, locomotor time 1	2.7	3.0	4.0	-0.7	1.7	1.8	-2.0	-2.0	2.0	1.7	1.6
Rest time, locomotor task time 1	0.4	0.4	1.7	1.3	-0.7	-0.2	0.6	0.6	-0.1	-0.5	-0.5
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.6	0.1	-0.5	-0.1	-0.1	-0.2	0.0	0.0
Vertical activity count, locomotor time 1	0.3	0.4	0.8	0.9	-0.8	-0.7	0.3	0.3	-0.6	-0.3	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.2	-0.2	0.0	-0.4	-0.4	-0.3	-0.1	0.1
Bouts of movement, locomotor time 2	3.6	3.9	5.6	-1.3	2.1	1.3	-2.4	-2.4	1.5	2.3	2.1
Total resting periods, locomotor time 2	2.8	3.0	4.5	-0.9	1.8	1.0	-2.1	-2.1	1.3	2.1	1.9
Rest time, locomotor task time 2	1.0	1.2	4.2	2.1	-1.3	-1.2	0.8	0.8	-0.7	-0.5	-0.5
Distance moved, locomotor task time 2	0.6	0.6	1.1	-0.9	0.7	1.0	-0.8	-0.8	0.9	0.5	0.5
Vertical activity count, locomotor time 2	0.5	0.6	1.4	0.2	0.4	1.2	-0.6	-0.6	0.8	0.9	0.8
Light reinforcement 1	0.0	0.1	0.2	0.3	-0.2	0.1	-0.2	-0.2	-0.4	-0.1	-0.2
Light reinforcement 2	1.4	1.9	3.4	0.3	-1.3	-1.1	1.3	1.3	-1.9	-1.6	-1.7
Bone: marrow area	3.9	8.4	10.3	1.8	-3.0	-3.2	3.0	3.0	-3.2	-2.9	-2.9
Bone: maximum diameter	0.3	0.6	1.0	-0.5	-0.5	-0.6	1.0	1.0	-0.7	-0.9	-0.9
Bone: maximum force	0.4	0.8	4.1	-2.0	0.5	-0.5	0.4	0.4	-0.5	-0.8	-0.6
Bone: maximum moment	0.4	0.7	3.7	-1.9	0.5	-0.4	0.4	0.4	-0.4	-0.7	-0.6
Mean time between licks in bursts	0.8	1.1	1.8	-0.6	1.1	0.7	-0.8	-0.8	1.2	1.4	1.3
Mean num. licks in bursts	1.1	1.3	2.2	0.1	0.7	0.6	-1.5	-1.5	1.0	1.4	1.4
Cd content in liver	0.4	0.5	0.9	0.9	-0.8	-0.8	0.4	0.4	-0.5	-0.7	-0.6
Co content in liver	0.9	1.0	2.3	1.5	-0.2	0.4	-1.2	-1.2	0.6	1.2	1.0
Cu content in liver	0.3	0.4	1.1	-0.4	0.5	0.8	-0.1	-0.1	0.7	0.5	1.1
Fe content in liver	0.0	0.0	0.2	-0.0	0.1	0.0	0.0	0.0	0.1	0.1	0.4
K content in liver	0.8	0.8	1.7	-1.0	-0.1	-0.4	1.1	1.1	-0.2	-1.3	-0.9
Mg content in liver	1.0	1.1	1.8	-0.6	-0.4	-1.1	1.3	1.3	-0.7	-1.4	-1.0
Mn content in liver	0.4	0.5	2.2	-1.5	0.8	0.7	0.1	0.1	0.7	-0.1	-0.0
Na content in liver	0.1	0.2	0.8	-0.9	0.5	-0.0	-0.3	-0.3	0.1	-0.0	-0.0
Rb content in liver	1.1	1.4	2.4	1.5	-1.5	-1.4	1.0	1.0	-1.0	-1.0	-0.9
Se content in liver	0.1	0.1	0.4	-0.6	0.2	0.0	0.4	0.4	0.1	-0.2	-0.0
Sr content in liver	4.8	4.4	7.1	-2.6	2.7	1.8	-1.8	-1.8	1.9	2.0	1.9
Zn content in liver	2.2	2.5	5.7	-2.4	2.1	1.1	-1.5	-1.5	1.3	1.0	1.1
Bone: minimum diameter	3.1	5.8	7.0	1.0	-2.3	-2.6	2.5	2.5	-2.7	-2.6	-2.6
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.3	0.0	-0.4	0.1	0.1	-0.2	-0.2	-0.0
Time in novel zone, hab. session 1	0.3	0.3	1.7	1.3	-0.7	-0.5	0.1	0.1	-0.4	0.0	-0.1
Total zone transitions, hab. session 1	0.5	0.6	1.7	-0.7	1.0	0.8	-0.6	-0.6	1.3	0.6	0.6
Total locomotion distance, hab. session 1	0.1	0.2	0.6	0.1	-0.3	-0.8	0.3	0.3	-0.5	-0.5	-0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.3	-0.5	0.4	-0.1	-0.3	-0.3	0.2	0.0	-0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.5	0.7	-0.3	-0.0	-0.4	-0.4	0.0	0.2	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.7	-0.8	0.4	-0.1	0.2	0.2	-0.2	0.0	0.0
Total zone transitions, hab. session 2	0.4	0.6	1.7	-1.3	1.0	0.2	-0.6	-0.6	0.8	0.4	0.5
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.4	0.2	-0.6	-0.1	-0.1	-0.1	0.1	0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.7	-0.2	-0.1	-0.8	0.2	0.2	-0.4	-0.3	-0.3
Novel to familiar place preference ratio	0.5	0.5	2.1	-1.4	0.9	0.8	-0.0	-0.0	0.5	0.2	0.3
Novelty place preference	0.3	0.3	1.1	-1.1	0.6	0.7	0.2	0.2	0.4	0.1	0.2
Time in novel zone, NPP test	0.3	0.3	1.3	-1.1	0.8	0.6	-0.0	-0.0	0.4	0.3	0.4
Total zone transitions, NPP test	1.0	1.5	2.5	-1.4	1.6	0.9	-1.1	-1.1	1.3	1.1	1.0
Total locomotion distance, NPP test	0.1	0.1	0.1	-0.4	0.4	-0.0	-0.3	-0.3	0.3	0.3	0.1
Locomotion velocity, NPP test	0.0	0.1	0.3	-0.3	0.3	0.2	-0.1	-0.1	0.5	0.2	-0.0
Intraocular pressure	0.4	0.6	1.2	0.4	0.4	0.6	-1.0	-1.0	0.2	1.1	0.9
Delta distance traveled before/after self-admin	0.3	0.3	1.2	1.1	-0.7	-0.3	0.5	0.5	-0.3	-0.1	-0.1
Delta ambulatory time before/after self-admin	0.2	0.3	1.5	1.2	-0.6	-0.2	0.3	0.3	-0.2	0.1	0.1
Parametrial fat weight	4.1	7.9	9.9	1.7	-2.9	-2.6	3.1	3.1	-3.1	-2.8	-2.9
Pavlov. Cond. lever latency	0.2	0.3	1.4	1.2	-0.3	0.3	-0.1	-0.1	0.2	0.7	0.5
Pavlov. Cond. magazine entry latency	0.2	0.3	1.5	-1.2	0.4	-0.3	-0.1	-0.1	-0.3	-0.6	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	-0.7	0.2	-0.2	-0.3	-0.3	-0.2	-0.5	-0.3
Pavlov. Cond. index score	0.1	0.2	0.8	-0.9	0.4	0.0	-0.5	-0.5	-0.0	-0.3	-0.2
Pavlov. Cond. latency score	0.1	0.2	0.6	-0.8	0.1	-0.3	-0.1	-0.1	-0.2	-0.6	-0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.7	-0.5	-0.2	-0.4	0.2	0.2	-0.4	-0.8	-0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	1.0	-0.8	-0.5	0.9	0.9	-0.5	-0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.2	0.6	0.9	-0.7	-0.7	0.6	0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.0	-1.0	0.6	0.2	-0.6	-0.6	0.1	-0.2	-0.1
Pavlov. Cond. response bias	0.2	0.2	0.9	-1.0	0.5	0.1	-0.6	-0.6	0.1	-0.2	-0.1
Pavlov. Cond. lever latency	0.2	0.2	0.6	0.8	-0.2	0.6	0.3	0.3	0.6	-0.0	0.1
Pavlov. Cond. magazine entry latency	3.5	4.1	6.8	-2.6	2.3	1.1	-2.4	-2.4	1.1	1.8	1.8
Pavlov. Cond. change in total contacts	0.7	0.9	2.4	-1.5	1.0	0.0	-1.2	-1.2	0.0	0.6	0.6
Pavlov. Cond. index score	1.3	1.7	4.3	-2.1	1.4	0.3	-1.6	-1.6	0.1	1.0	0.9
Pavlov. Cond. latency score	1.0	1.2	3.8	-2.0	1.2	0.1	-1.3	-1.3	-0.1	0.8	0.7
Pavlov. Cond. lever contacts	0.6	0.9	2.0	-0.8	0.8	-0.0	-1.4	-1.4	0.1	1.0	0.8
Pavlov. Cond. magazine entry number	4.5	5.5	11.1	3.3	-2.8	-1.4	2.6	2.6	-1.4	-2.0	-2.0
Pavlov. Cond. intertrial magazine entries	0.8	1.1	2.3	1.5	-1.2	-0.4	1.0	1.0	-0.8	-1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	4.8	-2.2	1.6	0.4	-1.8	-1.8	0.3	1.1	1.0
Pavlov. Cond. response bias	1.2	1.7	2.8	-1.6	1.4	0.3	-1.7	-1.7	0.3	1.2	1.2
Time in closed arm before self-admin	0.3	0.3	0.9	-0.0	-0.5	-0.5	0.3	0.3	-0.6	-0.9	-0.9
Time in closed arm after self-admin	0.2	0.2	0.5	0.6	-0.5	-0.7	0.6	0.6	-0.3	-0.3	-0.3
Time in open arm before self-admin	0.3	0.3	1.4	1.2	-0.5	0.1	0.4	0.4	0.2	0.5	0.5
Time in open arm after self-admin	1.1	1.2	2.2	0.1	0.8	1.5	-1.0	-1.0	1.4	1.2	1.2
Bone: periosteal estimation	1.4	2.9	3.6	0.2	-1.5	-1.8	1.9	1.9	-1.8	-1.9	-1.8
Bone: periosteal perimeter	0.6	1.0	1.5	0.1	-0.9	-1.1	1.0	1.0	-1.2	-1.1	-1.1
Bone: post-yield work	5.1	7.0	11.9	0.4	-2.3	-2.7	2.5	2.5	-2.9	-3.5	-3.2
Progressive ratio test 1 active lever presses	1.0	1.0	1.5	1.1	-1.2	-1.2	0.9	0.9	-0.8	-1.0	-1.0
Progressive ratio test 1 breakpoint	0.8	0.8	1.4	1.2	-1.2	-1.1	0.7	0.7	-0.6	-0.8	-0.8
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.6	-0.5	-0.1	-0.7	0.6	0.6	-0.8	-0.4	-0.4
Progressive ratio test 2 active lever presses	1.8	2.0	3.5	1.0	-1.6	-1.9	1.1	1.1	-1.4	-1.5	-1.5
Progressive ratio test 2 breakpoint	2.1	2.3	3.4	1.4	-1.8	-1.8	1.2	1.2	-1.4	-1.6	-1.6
Progressive ratio test 2 inactive lever presses	1.8	2.1	4.4	0.4	-1.4	-2.1	1.2	1.2	-1.7	-1.6	-1.5
Incentive Sensitization - Responses	0.4	0.4	0.7	-0.3	-0.4	-0.8	0.5	0.5	-0.6	-0.9	-0.9
Incentive Sensitization - Breakpoint	0.8	0.8	1.3	-0.2	-0.7	-1.1	0.8	0.8	-0.9	-1.2	-1.2
Sum of active levers in priming session hrs 5-6	1.6	1.6	2.2	-1.2	1.4	1.2	-1.5	-1.5	1.2	1.0	1.0
Progressive ratio	0.2	0.2	0.7	-0.0	-0.4	-0.8	0.3	0.3	-0.2	-0.6	-0.7
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.3	-0.1	-0.1	-0.3	-0.3	0.4	0.6	0.2
Seeking ratio, punishment vs. effort	0.2	0.2	0.6	0.2	0.2	0.5	-0.2	-0.2	0.2	0.8	0.7
Retroperitoneal fat weight	4.6	15.0	19.9	3.0	-4.1	-3.2	4.5	4.5	-3.6	-3.8	-4.1
Reaction time number correct	0.5	0.7	1.0	-0.7	0.9	0.6	-0.8	-0.8	1.0	1.0	0.9
Reaction time mean minus median	1.0	1.3	2.5	-0.8	1.1	1.1	-1.6	-1.6	0.8	0.9	0.8
Reaction time mean minus median AUC	1.9	2.4	4.6	-0.5	1.3	1.5	-2.1	-2.1	1.3	1.5	1.5
Reaction time num false alarms	0.2	0.3	0.7	0.6	0.0	0.7	0.1	0.1	0.6	0.6	0.8
Reaction time num false alarms AUC	0.6	0.9	2.0	-0.0	0.7	1.4	-0.2	-0.2	1.3	1.0	1.3
Reaction time trials correct on left	0.5	0.7	1.0	-0.7	0.9	0.6	-0.8	-0.8	1.0	1.0	0.9
Reaction time trials on left	0.6	0.9	1.2	-0.7	1.0	0.7	-0.9	-0.9	1.1	1.1	1.0
Reaction time mean	0.5	0.7	2.0	-0.2	0.6	0.2	-1.4	-1.4	0.3	0.7	0.7
Reaction time mean AUC	0.4	0.5	1.8	0.0	0.3	-0.1	-1.3	-1.3	0.1	0.5	0.5
Median of all reaction times	0.2	0.3	0.8	-0.4	0.4	-0.1	-0.9	-0.9	-0.0	0.4	0.4
Reaction time omissions	0.8	1.1	1.7	-0.4	0.9	1.3	-1.0	-1.0	1.3	1.1	1.2
Reaction time false alarm rate	0.1	0.2	0.3	0.5	-0.2	0.6	0.5	0.5	0.3	0.1	0.4
Reaction time premature initiation rate	0.6	0.8	5.0	-2.2	0.9	0.4	0.4	0.4	0.5	-0.3	-0.1
Reaction time premature initiations	1.3	1.9	6.8	-2.6	1.7	1.2	-0.6	-0.6	1.4	0.8	0.9
Std. dev. reaction times	1.0	1.5	3.0	0.0	0.8	1.1	-1.7	-1.7	1.0	1.2	1.2
Reaction time trials completed	0.6	0.9	1.2	-0.7	1.0	0.7	-0.9	-0.9	1.1	1.1	1.0
Reaction time trials AUC	0.4	0.6	0.9	-0.6	0.8	0.5	-0.8	-0.8	0.9	0.9	0.8
Run reversals in cocaine runway, females	0.7	0.7	1.4	-0.6	-0.3	-0.5	1.2	1.2	-0.8	-0.8	-0.8
Run reversals in cocaine runway, males	0.8	0.7	1.2	0.8	-0.8	0.0	1.1	1.1	-0.5	-0.9	-1.0
Latency to leave start box in cocaine runway	3.2	3.5	4.5	0.5	-1.7	-2.1	2.0	2.0	-2.0	-2.1	-2.1
Latency to leave start box in cocaine runway, F	0.8	0.8	1.3	-0.2	-0.6	-0.9	0.9	0.9	-1.0	-1.1	-1.1
Latency to leave start box in cocaine runway, M	3.2	3.0	4.5	1.9	-2.1	-1.8	1.6	1.6	-1.5	-1.7	-1.6
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.5	-0.5	-0.5	0.4	0.4	-0.2	-0.1	-0.2
Total sessions with >9 infusions	2.2	2.4	3.5	1.2	-1.6	-1.9	1.7	1.7	-1.7	-1.4	-1.4
Short access day 1 total inactive lever presses	1.8	2.0	2.5	0.9	-1.5	-1.6	1.6	1.6	-1.4	-1.4	-1.3
Short access day 10 total inactive lever presses	1.1	1.2	2.7	1.6	-1.4	-1.1	1.0	1.0	-1.1	-0.6	-0.6
Short access day 1 total infusions	1.0	1.0	2.6	0.9	-1.1	-1.6	1.0	1.0	-1.0	-0.7	-0.7
Short access day 10 total infusions	3.9	4.3	8.5	0.3	-1.7	-2.9	2.2	2.2	-2.3	-2.1	-2.0
Short access total infusions	1.5	1.6	3.6	0.4	-1.2	-1.9	1.4	1.4	-1.3	-1.1	-1.1
Short access day 1 locomotion	0.4	0.4	1.0	-0.3	-0.2	-1.0	0.7	0.7	-0.6	-0.5	-0.4
Short access day 10 total locomotion	1.5	1.6	3.1	-0.0	-0.9	-1.8	1.2	1.2	-1.7	-1.2	-1.2
Short access total locomotion	1.2	1.2	2.2	-0.5	-0.6	-1.5	1.2	1.2	-1.4	-1.1	-1.0
One hour access (0.3 mA shock)	3.4	3.9	6.5	1.9	-2.3	-2.5	1.7	1.7	-1.9	-1.9	-1.8
Compulsive drug intake	3.2	3.3	5.2	-0.8	1.7	2.3	-1.5	-1.5	1.9	2.1	2.1
One hour access (shock baseline)	4.1	4.8	7.5	2.1	-2.5	-2.7	1.7	1.7	-2.1	-2.3	-2.2
Social response proportion	0.1	0.1	0.3	-0.4	-0.2	-0.1	0.3	0.3	0.0	-0.5	-0.2
Social responses	0.3	0.4	1.0	-0.2	0.4	1.0	-0.5	-0.5	1.0	0.5	0.8
Social time	1.2	1.6	2.4	-0.1	0.9	1.2	-1.4	-1.4	1.6	1.4	1.5
Soleus weight	1.2	3.5	7.9	2.8	-2.4	-1.7	1.3	1.3	-1.6	-1.6	-1.6
Bone: stiffness	0.1	0.2	1.1	-1.0	0.1	-0.3	0.1	0.1	-0.4	-0.6	-0.3
Tibialis anterior weight	4.5	15.4	35.8	-6.0	5.3	3.9	-2.8	-2.8	3.5	2.6	3.1
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.9	-0.7	-0.2	-1.0	0.8	0.8	-0.8	-0.9	-1.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.6	-0.8	0.3	-0.3	0.1	0.1	0.1	0.1	0.0
Time to tail flick, test, before self-admin	1.0	0.9	2.0	-0.1	-0.6	-0.6	1.4	1.4	-0.9	-1.0	-1.0
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	-0.1	0.4	-0.0	-0.0	0.3	0.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	-0.2	0.3	0.4	-0.4	-0.4	0.5	0.6	0.6
Delta time to tail flick, test, before/after SA	2.3	2.1	3.2	-0.1	1.1	1.5	-1.8	-1.8	1.5	1.5	1.5
Tibia length	0.3	0.9	5.0	-2.2	1.1	0.7	-0.3	-0.3	0.3	-0.3	-0.3
Ambulatory time before self-admin	1.2	1.2	2.6	-1.6	1.2	0.9	-1.3	-1.3	0.8	0.6	0.6
Ambulatory time after self-admin	0.2	0.3	0.6	-0.6	-0.2	-0.3	0.2	0.2	-0.7	-0.7	-0.8
Bone: tissue strength	0.3	0.3	0.7	0.8	-0.7	-0.5	0.3	0.3	-0.6	-0.6	-0.5
Total heroin consumption	5.5	6.4	8.3	-2.2	2.9	2.8	-2.4	-2.4	2.7	2.4	2.4
Bone: trabecular number	0.2	0.4	0.7	-0.9	-0.0	-0.4	0.5	0.5	-0.7	-0.8	-0.6
Bone: trabecular spacing	0.8	1.1	1.7	0.6	0.5	0.5	-1.3	-1.3	1.0	1.3	1.2
Bone: trabecular thickness	0.7	0.8	1.4	0.6	-1.0	-0.8	0.7	0.7	-0.9	-1.1	-1.2
Bone: trabecular tissue density	1.1	1.6	5.4	2.3	-1.7	-0.8	1.0	1.0	-0.7	-0.9	-0.9
Water consumed over 24 hours	0.5	0.6	0.9	-0.6	0.6	0.7	-0.7	-0.7	0.9	0.8	0.9
Number of responses in last shaping day	0.3	0.3	0.6	-0.2	0.5	0.3	-0.4	-0.4	0.6	0.7	0.8