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Intermittent access intake day 1-15 change

Intermittent access intake change from day 1 to day 15

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

3 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 7 16845355 16970279 1 1 3.0e-24 NaN NA NA NA
2 8 33238527 34621030 1 1 6.5e-12 0.0021 1.9e-12 -425 Ddx25
3 8 108584253 109479622 1 1 2.5e-07 0.0375 6.2e-03 -73 Apeh

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 171.8 1 1 33 0 1 NA
Body weight 11.2 1 1 33 0 1 NA
Epididymis fat weight 136.2 1 1 33 0 1 NA
Glucose 6.6 1 0 0 0 1 NA
Heart weight 11.4 1 0 0 0 1 NA
Left kidney weight 62.7 1 1 33 0 1 NA
Right kidney weight 67.3 1 1 33 0 1 NA
Tail length 46.7 2 1 33 0 1 Ddx25 NA
Length with tail 4.0 1 0 0 0 1 NA
Length without tail 120.2 1 1 33 0 1 NA
Liver weight, left 13.8 2 1 33 0 1 Apeh NA
Liver weight, right 7.2 2 0 0 0 1 Ddx25 NA
Parametrial fat weight 26.4 1 1 33 0 1 NA
Retroperitoneal fat weight 4.2 1 0 0 0 1 NA
Intraocular pressure 29.4 1 1 33 0 1 NA
Extensor digitorum longus weight 39.2 1 1 33 0 1 NA
Soleus weight 21.9 1 1 33 0 1 NA
Tibialis anterior weight 96.0 1 1 33 0 1 NA
Tibia length 7.4 1 0 0 0 1 NA
Number of licking bursts 242.4 1 1 33 0 1 NA
Food consumed during 24 hour testing period 17.5 1 0 0 0 1 NA
Times rat made contact with spout 121.6 1 1 33 0 1 NA
Mean time between licks in bursts 90.5 1 1 33 0 1 NA
Mean num. licks in bursts 258.2 1 1 33 0 1 NA
Std. dev. time between licks in bursts 148.9 2 1 33 0 1 Apeh NA
Water consumed over 24 hours 5.7 1 0 0 0 1 NA
Indifference point 0 sec 9.6 3 1 33 0 1 Ddx25 Apeh NA
Indifference point AUC 66.7 1 1 33 0 1 NA
Indifference point function ln k 4.4 1 0 0 0 1 NA
Indifference point function log k 4.4 1 0 0 0 1 NA
Delay discounting total patch changes 0 sec 20.1 1 1 33 0 1 NA
Delay discounting total patch changes 12 sec 80.9 2 1 33 0 1 Ddx25 NA
Delay discounting total patch changes 18 sec 141.8 2 1 33 0 1 Apeh NA
Delay discounting total patch changes 24 sec 43.7 1 1 33 0 1 NA
Delay discounting total patch changes 6 sec 74.9 2 1 33 0 1 Apeh NA
Delay discounting water rate 0 sec 11.8 1 0 0 0 1 NA
Delay discounting water rate 12 sec 44.2 1 1 33 0 1 NA
Delay discounting water rate 18 sec 10.5 1 0 0 0 1 NA
Delay discounting water rate 24 sec 100.9 1 1 33 0 1 NA
Delay discounting water rate 6 sec 70.2 1 1 33 0 1 NA
Locomotor testing distance 14.0 1 0 0 0 1 NA
Locomotor testing rearing 23.9 1 1 33 0 1 NA
Light reinforcement 1 84.1 1 1 33 0 1 NA
Reaction time number correct 9.4 1 0 0 0 1 NA
Reaction time num false alarms 90.1 1 1 33 0 1 NA
Reaction time num false alarms AUC 66.3 2 1 33 0 1 Ddx25 NA
Reaction time trials correct on left 9.4 1 0 0 0 1 NA
Reaction time trials on left 10.3 1 0 0 0 1 NA
Reaction time mean 62.5 1 1 33 0 1 NA
Reaction time mean AUC 89.1 1 1 33 0 1 NA
Median of all reaction times 80.2 1 1 33 0 1 NA
Reaction time false alarm rate 54.5 2 1 33 0 1 Ddx25 NA
Reaction time premature initiation rate 47.3 1 1 33 0 1 NA
Reaction time premature initiations 49.8 1 1 33 0 1 NA
Std. dev. reaction times 27.0 1 1 33 0 1 NA
Reaction time trials completed 10.3 1 0 0 0 1 NA
Reaction time trials AUC 15.6 1 0 0 0 1 NA
Social responses 108.6 1 1 33 0 1 NA
Social time 7.8 1 0 0 0 1 NA
Cocaine response after cond. corrected 135.7 1 1 33 0 1 NA
Cocaine response after cond. not corrected 176.6 1 1 33 0 1 NA
Cocaine response before conditioning 28.6 1 1 33 0 1 NA
Saline control response 27.5 2 1 33 0 1 Apeh NA
Condit. Reinf. active minus inactive responses 46.4 1 1 33 0 1 NA
Condit. Reinf. active-inactive response ratio 68.7 1 1 33 0 1 NA
Condit. Reinf. active responses 11.1 1 0 0 0 1 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0 1 NA
Pavlov. Cond. lever latency 60.5 1 1 33 0 1 NA
Pavlov. Cond. magazine entry latency 173.4 1 1 33 0 1 NA
Pavlov. Cond. change in total contacts 216.7 1 1 33 0 1 NA
Pavlov. Cond. index score 102.2 1 1 33 0 1 NA
Pavlov. Cond. latency score 110.3 1 1 33 0 1 NA
Pavlov. Cond. lever contacts 29.4 1 1 33 0 1 NA
Pavlov. Cond. magazine entry number 244.9 1 1 33 0 1 NA
Pavlov. Cond. intertrial magazine entries 106.2 1 1 33 0 1 NA
Pavlov. Cond. lever-magazine prob. diff. 90.6 1 1 33 0 1 NA
Pavlov. Cond. response bias 51.3 1 1 33 0 1 NA
Conditioned reinforcement - actives 18.5 1 0 0 0 1 NA
Conditioned reinforcement - inactives 32.2 1 1 33 0 1 Apeh
Conditioned locomotion 7.6 2 0 0 0 1 Apeh NA
Intermittent access intake escalation 62.9 3 2 67 0 1 Ddx25 Apeh NA
Intermittent access intake escalation 2 29.0 3 2 67 0 1 Ddx25 Apeh NA
Intermitt. access day 1 inactive lever presses 30.6 1 1 33 0 1 NA
Intermitt. access day 15 inactive lever presses 27.4 1 1 33 0 1 Apeh
Intermitt. access escalation Index 10.5 2 0 0 0 1 Ddx25 NA
Intermittent access day 1 total infusions 52.9 1 1 33 0 1 NA
Intermittent access day 15 total infusions 7.9 1 0 0 0 1 Ddx25
Intermittent access terminal intake (last 3 days) 7.5 1 0 0 0 1 Ddx25
Intermittent access day 1 locomotion 27.1 1 1 33 0 1 NA
Intermittent access standard deviation 34.3 1 1 33 0 1 Apeh
Cocaine induced anxiety 6.4 1 0 0 0 1 Apeh
Post-drug Anxiety 20.6 1 0 0 0 1 NA
Lifetime Intake 7.7 1 0 0 0 1 Ddx25
Incentive Sensitization - Responses 8.7 1 0 0 0 1 Apeh
Incentive Sensitization - Breakpoint 8.8 1 0 0 0 1 Apeh
Progressive ratio test 1 active lever presses 10.9 2 0 0 0 1 Apeh NA
Progressive ratio test 1 breakpoint 10.3 2 0 0 0 1 Apeh NA
Progressive ratio test 1 inactive lever presses 9.7 2 0 0 0 1 Apeh NA
Progressive ratio test 2 active lever presses 12.2 1 0 0 0 1 NA
Progressive ratio test 2 breakpoint 61.6 1 1 33 0 1 NA
Progressive ratio test 2 inactive lever presses 41.5 1 1 33 0 1 Apeh
Total sessions with >9 infusions 12.6 1 0 0 0 1 Apeh
Short access day 1 total inactive lever presses 7.7 1 0 0 0 1 Apeh
Short access day 10 total inactive lever presses 26.2 2 1 33 0 1 Apeh NA
Short access day 1 total infusions 23.1 1 0 0 0 1 Ddx25
Short access day 10 total infusions 24.0 1 1 33 0 1 NA
Short access total infusions 13.0 1 0 0 0 1 Ddx25
Short access day 1 locomotion 14.3 2 0 0 0 1 Ddx25 NA
Short access day 10 total locomotion 6.4 1 0 0 0 1 Apeh
Short access total locomotion 10.7 1 0 0 0 1 Apeh
Compulsive drug intake 26.5 2 1 33 0 1 Apeh NA
One hour access (0.3 mA shock) 12.4 2 0 0 0 1 Ddx25 NA
One hour access (shock baseline) 7.2 1 0 0 0 1 Ddx25
Number of responses in last shaping day 12.0 1 0 0 0 1 Apeh
Context. condit. distance diff. score 240.2 1 1 33 0 1 NA
Locomotion velocity, session 1 190.8 1 1 33 0 1 NA
Locomotion distance, session 1 609.6 1 1 33 0 1 NA
Locomotion velocity, session 2 139.6 1 1 33 0 1 NA
Locomotion distance, session 2 1269.9 1 1 33 0 1 NA
Locomotion velocity, session 3 178.9 1 1 33 0 1 NA
Locomotion distance, session 3 62.1 2 1 33 0 1 Ddx25 NA
Stereotopy head waving bouts, day 3 8.8 1 0 0 0 1 NA
Stereotopy head waving duration, day 3 33.2 1 1 33 0 1 NA
Locomotion velocity, session 7 98.9 1 1 33 0 1 NA
Locomotion distance, session 7 31.8 1 1 33 0 1 NA
Stereotopy head waving bouts, day 7 68.4 1 1 33 0 1 NA
Stereotopy head waving duration, day 7 102.2 1 1 33 0 1 NA
Locomotion distance, session 8 171.7 1 1 33 0 1 NA
Degree of sensitization distance 198.5 1 1 33 0 1 NA
Degree of sensitization stereotypy 37.5 1 1 33 0 1 NA
Condit. Reinf. active minus inactive responses 5.6 1 0 0 0 1 NA
Condit. Reinf. active-inactive response ratio 107.3 1 1 33 0 1 NA
Condit. Reinf. active responses 20.0 1 0 0 0 1 NA
Condit. Reinf. inactive responses 17.2 1 0 0 0 1 NA
Incentive salience index mean 15.6 1 0 0 0 1 NA
Condit. Reinf. lever presses 35.1 1 1 33 0 1 NA
Time in familiar zone, hab. session 1 16.4 1 0 0 0 1 NA
Time in novel zone, hab. session 1 17.4 1 0 0 0 1 NA
Total zone transitions, hab. session 1 673.8 1 1 33 0 1 NA
Total locomotion distance, hab. session 1 279.4 1 1 33 0 1 NA
Locomotion velocity, hab. session 1 349.5 1 1 33 0 1 NA
Time in familiar zone, hab. session 2 48.9 1 1 33 0 1 NA
Time in novel zone, hab. session 2 58.4 1 1 33 0 1 NA
Total zone transitions, hab. session 2 421.2 1 1 33 0 1 NA
Total locomotion distance, hab. session 2 214.3 1 1 33 0 1 NA
Locomotion velocity, hab. session 2 225.0 1 1 33 0 1 NA
Novel to familiar place preference ratio 6.2 1 0 0 0 1 Apeh
Novelty place preference 7.0 1 0 0 0 1 Apeh
Time in novel zone, NPP test 6.8 1 0 0 0 1 Apeh
Total zone transitions, NPP test 376.1 1 1 33 0 1 NA
Total locomotion distance, NPP test 269.3 1 1 33 0 1 NA
Locomotion velocity, NPP test 317.8 1 1 33 0 1 NA
Pavlov. Cond. lever latency 8.4 2 0 0 0 1 Ddx25 NA
Pavlov. Cond. magazine entry latency 35.2 3 1 33 0 1 Ddx25 Apeh NA
Pavlov. Cond. change in total contacts 40.1 1 1 33 0 1 NA
Pavlov. Cond. index score 28.3 2 1 33 0 1 Ddx25 NA
Pavlov. Cond. latency score 10.7 2 0 0 0 1 Ddx25 NA
Pavlov. Cond. lever contacts 11.3 2 0 0 0 1 Ddx25 NA
Pavlov. Cond. magazine entry number 61.6 1 1 33 0 1 NA
Pavlov. Cond. lever-magazine prob. diff. 46.5 2 1 33 0 1 Apeh NA
Pavlov. Cond. response bias 28.8 2 1 33 0 1 Apeh NA
Bone: apparent density 31.2 1 1 33 0 1 NA
Bone surface 41.3 1 1 33 0 1 NA
Bone volume 47.7 1 1 33 0 1 NA
Bone: connectivity density 8.5 1 0 0 0 1 NA
Bone: cortical area 13.1 1 0 0 0 1 Ddx25
Bone: cortical porosity 99.1 2 1 33 0 1 Ddx25 NA
Bone: cortical porosity 83.1 2 1 33 0 1 Ddx25 NA
Bone: cortical thickness 8.3 2 0 0 0 1 Ddx25 NA
Bone: cortical thickness 17.9 1 0 0 0 1 NA
Bone: elastic displacement 28.2 1 1 33 0 1 NA
Bone: endosteal estimation 18.4 1 1 33 0 1 NA
Bone: final force 30.5 2 1 33 0 1 Ddx25 NA
Bone: final moment 24.5 2 1 33 0 1 Ddx25 NA
Bone: marrow area 15.3 1 1 33 0 1 NA
Bone: maximum diameter 7.6 1 0 0 0 1 Ddx25
Bone: maximum force 32.6 2 1 33 0 1 Ddx25 NA
Bone: maximum moment 22.9 2 1 33 0 1 Ddx25 NA
Bone: minimum diameter 46.1 2 1 33 0 1 Ddx25 NA
Bone: periosteal estimation 7.0 2 0 0 0 1 Ddx25 NA
Bone: periosteal perimeter 8.8 1 0 0 0 1 NA
Bone: post-yield work 124.3 1 1 33 0 1 NA
Bone: stiffness 70.9 2 1 33 0 1 Ddx25 NA
Bone: tissue strength 136.0 1 1 33 0 1 NA
Bone: trabecular number 64.1 1 1 33 0 1 NA
Bone: trabecular spacing 5.7 1 0 0 0 1 NA
Bone: trabecular thickness 13.8 1 0 0 0 1 NA
Bone: trabecular tissue density 66.6 1 1 33 0 1 NA
Breakpoint value in progressive ratio session 5.5 1 0 0 0 1 Ddx25
Distance traveled before self-admin 12.6 1 0 0 0 1 NA
Delta time in closed arm before/after self-admin 8.1 1 0 0 0 1 Ddx25
Delta time in open arm before/after self-admin 40.2 1 1 33 0 1 NA
Extinction: sum of active levers before priming 12.2 1 0 0 0 1 NA
Active lever presses in extinction session 6 8.5 2 0 0 0 1 Ddx25 NA
Delta distance traveled before/after self-admin 11.3 1 0 0 0 1 NA
Time in closed arm before self-admin 78.0 1 1 33 0 1 NA
Time in closed arm after self-admin 40.2 1 1 33 0 1 NA
Time in open arm after self-admin 31.3 1 1 33 0 1 NA
Delta time to tail flick, vehicle, before/after SA 7.5 1 0 0 0 1 NA
Delta time to tail flick, test, before/after SA 20.0 1 0 0 0 1 NA
Ambulatory time before self-admin 8.0 2 0 0 0 1 Apeh NA
Total heroin consumption 21.4 1 0 0 0 1 Ddx25
Fecal boli incidents, locomotor time 1 11.8 1 0 0 0 1 NA
Change in fecal boli incidents, locomotor task 8.8 1 0 0 0 1 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0 0 1 NA
Time >=10cm from walls, locomotor time 2 27.2 1 1 33 0 1 NA
Total resting periods, locomotor time 2 6.0 1 0 0 0 1 NA
Rest time, locomotor task time 2 8.8 1 0 0 0 1 NA
Distance moved, locomotor task time 2 13.1 1 0 0 0 1 NA
Weight adjusted by age 25.0 1 1 33 0 1 NA
Seeking ratio, delayed vs. immediate footshock 5.3 1 0 0 0 1 NA
Locomotion in novel chamber 10.2 1 0 0 0 1 NA
Run reversals in cocaine runway, males 39.3 1 1 33 0 1 NA
Latency to leave start box in cocaine runway 18.8 1 0 0 0 1 NA
Cd content in liver 239.3 1 1 33 0 1 NA
Co content in liver 143.3 1 1 33 0 1 NA
Cu content in liver 4.8 1 0 0 0 1 Apeh
Fe content in liver 10.3 1 0 0 0 1 NA
K content in liver 87.3 1 1 33 0 1 NA
Mn content in liver 207.1 1 1 33 0 1 NA
Rb content in liver 31.4 1 1 33 0 1 NA
Se content in liver 47.0 1 1 33 0 1 NA
Sr content in liver 14.6 1 0 0 0 1 Ddx25
Zn content in liver 46.0 1 1 33 0 1 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 0.92
Adipose alternative TSS 0 0.000 1.00
Adipose gene expression 1 0.012 1.00
Adipose isoform ratio 0 0.000 0.97
Adipose intron excision ratio 0 0.000 0.98
Adipose mRNA stability 0 0.000 0.95
BLA alternative polyA 0 0.000 1.02
BLA alternative TSS 0 0.000 0.95
BLA gene expression 0 0.000 1.02
BLA isoform ratio 0 0.000 1.04
BLA intron excision ratio 0 0.000 0.97
BLA mRNA stability 0 0.000 1.03
Brain alternative polyA 0 0.000 0.95
Brain alternative TSS 0 0.000 1.03
Brain gene expression 0 0.000 1.02
Brain isoform ratio 0 0.000 1.01
Brain intron excision ratio 0 0.000 0.97
Brain mRNA stability 0 0.000 0.97
Eye alternative polyA 0 0.000 1.02
Eye alternative TSS 0 0.000 0.97
Eye gene expression 0 0.000 0.97
Eye isoform ratio 0 0.000 1.00
Eye intron excision ratio 0 0.000 1.01
Eye mRNA stability 0 0.000 1.10
IL alternative polyA 0 0.000 1.10
IL alternative TSS 0 0.000 1.05
IL gene expression 0 0.000 1.00
IL isoform ratio 0 0.000 0.97
IL intron excision ratio 0 0.000 0.94
IL mRNA stability 0 0.000 0.95
LHb alternative polyA 0 0.000 1.00
LHb alternative TSS 0 0.000 1.24
LHb gene expression 0 0.000 1.01
LHb isoform ratio 0 0.000 1.01
LHb intron excision ratio 0 0.000 0.90
LHb mRNA stability 0 0.000 1.01
Liver alternative polyA 0 0.000 0.99
Liver alternative TSS 0 0.000 0.95
Liver gene expression 0 0.000 0.99
Liver isoform ratio 0 0.000 0.99
Liver intron excision ratio 0 0.000 0.98
Liver mRNA stability 0 0.000 0.98
NAcc alternative polyA 0 0.000 1.01
NAcc alternative TSS 0 0.000 1.02
NAcc gene expression 0 0.000 1.01
NAcc isoform ratio 0 0.000 1.02
NAcc intron excision ratio 0 0.000 0.97
NAcc mRNA stability 0 0.000 1.05
OFC alternative polyA 0 0.000 1.09
OFC alternative TSS 0 0.000 1.09
OFC gene expression 0 0.000 1.02
OFC isoform ratio 0 0.000 0.96
OFC intron excision ratio 0 0.000 0.93
OFC mRNA stability 0 0.000 0.98
PL alternative polyA 0 0.000 1.06
PL alternative TSS 0 0.000 1.01
PL gene expression 0 0.000 1.01
PL isoform ratio 1 0.045 1.09
PL intron excision ratio 0 0.000 0.95
PL mRNA stability 1 0.034 1.00

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.