Hub : Traits : Extensor digitorum longus weight : ← →

chr7:29,535-2,057,232

Trait: Extensor digitorum longus weight

Best TWAS P=1.471503e-07 · Best GWAS P=1.453537e-07 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Cd63	alternative TSS	ENSRNOT00000114033	0.04	0.03	top1	1	0.03	7.4e-04	5.1	5.1	3.2e-07	0.95	0.06	0.08	FALSE
2	Adipose	Ikzf4	gene expression	ENSRNOG00000005535	0.06	0.05	lasso	24	0.05	6.2e-06	5.1	-5.1	2.6e-07	-0.78	0.28	0.72	TRUE
3	Adipose	Dnajc14	gene expression	ENSRNOG00000006844	0.43	0.27	lasso	27	0.29	3.8e-32	4.3	5.1	2.6e-07	-0.86	0.74	0.26	FALSE
4	Adipose	Coq10a	gene expression	ENSRNOG00000029571	0.03	0.02	top1	1	0.02	3.6e-03	5.1	-5.1	2.6e-07	-0.97	0.03	0.04	FALSE
5	Adipose	Myl6	intron excision ratio	chr7:910945:911642	0.03	0.01	blup	1046	0.02	1.9e-03	5.1	5.2	2.4e-07	0.97	0.33	0.63	FALSE
6	Adipose	Atp5f1b	mRNA stability	ENSRNOG00000002840	0.19	0.12	lasso	39	0.12	1.5e-13	5.2	-5.1	3.1e-07	-0.96	0.22	0.78	FALSE
7	BLA	Gls2	alternative TSS	ENSRNOT00000099901	0.06	0.05	enet	10	0.06	3.3e-04	5.2	5.2	1.7e-07	1.00	0.27	0.70	FALSE
8	BLA	Naca	gene expression	ENSRNOG00000002632	0.05	0.06	top1	1	0.06	4.3e-04	5.2	5.2	2.5e-07	0.96	0.04	0.09	FALSE
9	BLA	Atp5f1b	gene expression	ENSRNOG00000002840	0.20	0.20	lasso	20	0.22	4.6e-12	5.2	-5.1	2.6e-07	-0.95	0.21	0.79	FALSE
10	BLA	Erbb3	gene expression	ENSRNOG00000004964	0.09	0.12	top1	1	0.12	7.2e-07	5.1	-5.1	2.6e-07	-0.98	0.20	0.46	FALSE
11	BLA	Itga7	gene expression	ENSRNOG00000007905	0.12	0.10	lasso	13	0.11	1.4e-06	5.2	5.2	2.4e-07	1.00	0.33	0.67	FALSE
12	BLA	Stat2	gene expression	ENSRNOG00000031081	0.69	0.58	lasso	21	0.65	1.7e-45	5.1	-5.1	2.8e-07	-0.95	0.27	0.73	FALSE
13	BLA	Smarcc2	gene expression	ENSRNOG00000031135	0.08	0.08	enet	37	0.08	3.3e-05	5.2	-5.2	2.0e-07	-0.95	0.32	0.68	FALSE
14	BLA	Esyt1	gene expression	ENSRNOG00000060753	0.18	0.17	enet	85	0.17	1.8e-09	5.2	-5.2	1.6e-07	-0.96	0.28	0.72	FALSE
15	BLA	NA	gene expression	ENSRNOG00000062455	0.23	0.24	blup	1023	0.27	1.3e-14	5.3	-5.2	2.0e-07	-0.99	0.29	0.71	FALSE
16	BLA	Sarnp	isoform ratio	ENSRNOT00000009155	0.07	0.04	top1	1	0.04	3.6e-03	5.1	-5.1	2.7e-07	-0.99	0.06	0.06	FALSE
17	BLA	Rnf41	intron excision ratio	chr7:838301:841866	0.06	0.05	blup	961	0.05	1.2e-03	5.1	5.2	2.3e-07	0.98	0.28	0.66	FALSE
18	BLA	Myl6	intron excision ratio	chr7:910945:911978	0.05	0.01	top1	1	0.01	9.8e-02	5.1	-5.1	2.7e-07	-0.96	0.04	0.04	FALSE
19	BLA	Tmem198b	mRNA stability	ENSRNOG00000006827	0.06	0.06	top1	1	0.06	6.2e-04	5.2	-5.2	2.3e-07	-0.96	0.06	0.06	FALSE
20	BLA	Ormdl2	mRNA stability	ENSRNOG00000030120	0.06	0.04	blup	1388	0.05	1.5e-03	5.1	5.1	2.8e-07	0.99	0.30	0.58	FALSE
21	Brain	Rbms2	alternative polyA	ENSRNOT00000048848	0.05	0.03	lasso	2	0.03	3.8e-04	5.1	5.2	2.4e-07	0.93	0.28	0.70	FALSE
22	Brain	Rbms2	alternative polyA	ENSRNOT00000118787	0.05	0.03	top1	1	0.04	3.3e-04	5.1	-5.1	2.6e-07	-0.96	0.09	0.25	FALSE
23	Brain	Atp5f1b	gene expression	ENSRNOG00000002840	0.18	0.18	top1	1	0.18	4.5e-16	5.1	-5.1	3.2e-07	-0.96	0.23	0.77	FALSE
24	Brain	Tmem198b	gene expression	ENSRNOG00000006827	0.06	0.04	top1	1	0.04	1.4e-04	5.1	5.1	2.7e-07	0.97	0.11	0.23	FALSE
25	Brain	Itga7	gene expression	ENSRNOG00000007905	0.16	0.13	lasso	16	0.13	4.1e-12	5.1	5.1	3.1e-07	0.98	0.31	0.69	FALSE
26	Brain	Sarnp	gene expression	ENSRNOG00000030520	0.03	0.02	top1	1	0.02	2.3e-03	5.3	5.3	1.5e-07	0.98	0.05	0.05	TRUE
27	Brain	Ptges3	isoform ratio	ENSRNOT00000101866	0.06	0.04	top1	1	0.04	6.2e-05	5.2	-5.2	1.9e-07	-0.96	0.11	0.58	FALSE
28	Brain	Bloc1s1	isoform ratio	ENSRNOT00000010380	0.11	0.08	top1	1	0.08	4.4e-08	5.1	-5.1	2.7e-07	-0.99	0.28	0.71	FALSE
29	Brain	Rnf41	intron excision ratio	chr7:838383:841866	0.52	0.08	lasso	35	0.08	7.3e-08	5.1	-5.2	2.4e-07	-0.95	0.28	0.72	FALSE
30	Brain	Smarcc2	intron excision ratio	chr7:902231:902576	0.03	0.01	top1	1	0.01	2.2e-02	5.1	5.1	2.8e-07	0.98	0.04	0.06	FALSE
31	Brain	Ikzf4	mRNA stability	ENSRNOG00000005535	0.03	0.02	top1	1	0.02	5.5e-03	5.1	-5.1	2.7e-07	-0.99	0.04	0.04	FALSE
32	Brain	Dnajc14	mRNA stability	ENSRNOG00000006844	0.37	0.29	top1	1	0.29	2.2e-27	5.1	-5.1	2.7e-07	-0.99	0.27	0.73	FALSE
33	Brain	Stat2	mRNA stability	ENSRNOG00000031081	0.33	0.34	top1	1	0.34	1.2e-32	5.2	-5.2	2.0e-07	-0.97	0.23	0.77	FALSE
34	IL	Dgka	gene expression	ENSRNOG00000022943	0.30	0.07	enet	18	0.08	5.5e-03	5.1	-5.1	3.2e-07	-0.96	0.25	0.51	FALSE
35	IL	Myl6	gene expression	ENSRNOG00000054140	0.38	0.12	blup	1041	0.13	5.4e-04	4.4	-5.1	3.0e-07	-0.96	0.36	0.54	FALSE
36	IL	Esyt1	gene expression	ENSRNOG00000060753	0.16	0.02	top1	1	0.02	1.2e-01	5.1	-5.1	2.9e-07	-0.97	0.06	0.06	FALSE
37	IL	Dnajc14	mRNA stability	ENSRNOG00000006844	0.66	0.24	lasso	4	0.25	1.2e-06	5.1	-5.2	2.1e-07	0.87	0.30	0.69	TRUE
38	LHb	Cd63	alternative TSS	ENSRNOT00000090381	0.18	0.20	top1	1	0.20	2.0e-05	5.1	5.1	3.5e-07	0.99	0.08	0.07	FALSE
39	LHb	Itga7	gene expression	ENSRNOG00000007905	0.26	0.10	blup	1443	0.11	1.2e-03	5.0	5.1	2.9e-07	0.99	0.36	0.57	FALSE
40	Liver	Rbms2	alternative polyA	ENSRNOT00000118787	0.02	0.01	top1	1	0.01	9.2e-03	5.1	-5.1	3.2e-07	-0.96	0.03	0.03	FALSE
41	Liver	Dgka	gene expression	ENSRNOG00000022943	0.34	0.27	blup	1282	0.28	1.4e-31	5.1	5.1	2.7e-07	0.97	0.27	0.73	FALSE
42	Liver	AC128207.1	gene expression	ENSRNOG00000028837	0.05	0.04	top1	1	0.04	3.9e-05	5.2	-5.2	1.9e-07	-0.98	0.16	0.46	FALSE
43	Liver	Timeless	gene expression	ENSRNOG00000031916	0.24	0.22	blup	934	0.23	8.1e-25	4.5	5.1	3.5e-07	0.97	0.29	0.71	FALSE
44	Liver	Rbms2	isoform ratio	ENSRNOT00000048848	0.02	0.02	top1	1	0.02	2.5e-03	5.1	5.1	3.2e-07	0.96	0.03	0.04	FALSE
45	Liver	Sarnp	intron excision ratio	chr7:1251291:1261739	0.03	0.02	top1	1	0.02	3.1e-03	5.1	5.1	3.0e-07	0.98	0.04	0.04	FALSE
46	Liver	Sarnp	intron excision ratio	chr7:1254119:1261739	0.04	0.02	blup	1386	0.02	2.4e-03	5.1	-5.1	2.8e-07	-0.99	0.29	0.67	FALSE
47	Liver	Pa2g4	mRNA stability	ENSRNOG00000004904	0.02	0.01	top1	1	0.01	2.5e-02	5.1	5.1	2.8e-07	0.99	0.03	0.03	FALSE
48	Liver	Dgka	mRNA stability	ENSRNOG00000022943	0.14	0.09	blup	1282	0.09	4.5e-10	5.1	5.1	2.7e-07	0.98	0.28	0.72	FALSE
49	NAcc	Rbms2	alternative polyA	ENSRNOT00000048848	0.08	0.07	top1	1	0.07	4.0e-06	5.2	5.2	1.6e-07	0.96	0.16	0.79	FALSE
50	NAcc	Rbms2	alternative polyA	ENSRNOT00000118787	0.07	0.07	top1	1	0.07	8.9e-06	5.2	-5.2	1.7e-07	-0.96	0.17	0.74	FALSE
51	NAcc	Suox	alternative TSS	ENSRNOT00000008018	0.03	0.03	top1	1	0.04	1.2e-03	5.2	5.2	1.6e-07	0.98	0.04	0.05	FALSE
52	NAcc	Suox	alternative TSS	ENSRNOT00000108072	0.04	0.04	top1	1	0.04	6.1e-04	5.2	-5.2	2.0e-07	-0.98	0.04	0.06	FALSE
53	NAcc	Myl6	alternative TSS	ENSRNOT00000082518	0.05	0.04	top1	1	0.04	5.1e-04	5.2	-5.2	2.0e-07	-0.98	0.07	0.15	FALSE
54	NAcc	Myl6	alternative TSS	ENSRNOT00000099810	0.04	0.03	top1	1	0.03	1.8e-03	5.2	5.2	2.0e-07	0.98	0.05	0.09	FALSE
55	NAcc	Atp5f1b	gene expression	ENSRNOG00000002840	0.05	0.05	top1	1	0.05	1.0e-04	5.2	-5.2	1.6e-07	-0.96	0.07	0.38	FALSE
56	NAcc	Tmem198b	gene expression	ENSRNOG00000006827	0.05	0.02	blup	1397	0.03	3.3e-03	5.2	5.1	3.0e-07	0.98	0.34	0.61	FALSE
57	NAcc	Stat2	gene expression	ENSRNOG00000031081	0.81	0.31	lasso	33	0.34	8.9e-26	5.1	-5.1	2.9e-07	-0.95	0.28	0.72	FALSE
58	NAcc	Rbms2	isoform ratio	ENSRNOT00000048848	0.11	0.10	top1	1	0.10	1.1e-07	5.2	5.2	1.6e-07	0.96	0.17	0.82	FALSE
59	NAcc	Rbms2	isoform ratio	ENSRNOT00000088619	0.07	0.05	top1	1	0.05	8.0e-05	5.2	-5.2	1.6e-07	-0.95	0.08	0.30	FALSE
60	NAcc	Cnpy2	isoform ratio	ENSRNOT00000004895	0.07	0.05	top1	1	0.05	1.2e-04	5.2	5.2	2.5e-07	0.97	0.16	0.41	FALSE
61	NAcc	Rab5b	mRNA stability	ENSRNOG00000006130	0.03	0.01	blup	1145	0.03	5.3e-03	5.2	5.1	3.2e-07	0.96	0.31	0.49	TRUE
62	NAcc	Dnajc14	mRNA stability	ENSRNOG00000006844	0.43	0.33	lasso	14	0.35	7.6e-27	5.2	-5.2	2.3e-07	-1.00	0.27	0.72	FALSE
63	NAcc	Stat2	mRNA stability	ENSRNOG00000031081	0.16	0.14	lasso	29	0.16	6.0e-12	5.2	-5.1	2.9e-07	-0.96	0.29	0.71	FALSE
64	OFC	Myl6	gene expression	ENSRNOG00000054140	0.31	0.18	blup	1041	0.19	2.7e-05	5.1	-5.1	3.0e-07	-0.95	0.37	0.60	FALSE
65	OFC	Esyt1	gene expression	ENSRNOG00000060753	0.26	0.15	top1	1	0.15	2.2e-04	5.1	-5.1	2.9e-07	-0.97	0.06	0.07	FALSE
66	OFC	NA	gene expression	ENSRNOG00000062455	0.15	0.06	blup	1019	0.07	8.9e-03	5.1	-5.1	3.3e-07	-0.98	0.24	0.45	FALSE
67	OFC	Stat2	mRNA stability	ENSRNOG00000031081	0.37	0.27	top1	1	0.27	3.7e-07	5.2	-5.2	1.6e-07	-0.97	0.14	0.54	FALSE
68	PL	Sarnp	alternative TSS	ENSRNOT00000096123	0.04	0.01	lasso	9	0.01	4.0e-02	5.1	5.1	2.7e-07	0.96	0.25	0.59	FALSE
69	PL	Tmem198b	gene expression	ENSRNOG00000006827	0.05	0.03	blup	1397	0.04	9.5e-04	5.1	5.1	2.7e-07	0.98	0.32	0.62	FALSE
70	PL	Stat2	gene expression	ENSRNOG00000031081	0.72	0.55	blup	939	0.63	1.7e-60	5.2	-5.2	2.4e-07	-0.96	0.27	0.73	FALSE
71	PL	Smarcc2	gene expression	ENSRNOG00000031135	0.03	0.02	blup	1040	0.02	9.9e-03	5.1	-5.2	2.2e-07	-0.98	0.26	0.50	FALSE
72	PL	Zc3h10	gene expression	ENSRNOG00000040281	0.04	0.05	blup	1044	0.05	1.3e-04	5.2	5.2	2.2e-07	0.97	0.32	0.64	FALSE
73	PL	Baz2a	gene expression	ENSRNOG00000053881	0.06	0.06	top1	1	0.06	2.7e-05	5.2	-5.2	1.7e-07	-0.96	0.09	0.42	FALSE
74	PL	Esyt1	gene expression	ENSRNOG00000060753	0.18	0.15	lasso	9	0.17	4.7e-13	5.1	-5.1	2.7e-07	-0.96	0.29	0.71	FALSE
75	PL	Rnf41	intron excision ratio	chr7:838301:840354	0.17	0.13	top1	1	0.13	9.3e-10	5.2	5.2	2.0e-07	0.97	0.23	0.77	FALSE
76	PL	Rnf41	intron excision ratio	chr7:838301:841866	0.03	0.02	top1	1	0.02	2.0e-02	5.1	5.1	3.1e-07	0.97	0.04	0.04	FALSE
77	PL	Prim1	intron excision ratio	chr7:446523:449427	0.22	0.18	lasso	6	0.19	1.6e-14	5.2	5.2	2.5e-07	0.94	0.19	0.81	FALSE
78	PL	Myl6	intron excision ratio	chr7:910945:911642	0.04	0.04	top1	1	0.04	5.1e-04	5.2	5.2	1.9e-07	0.98	0.04	0.06	FALSE
79	PL	Myl6	intron excision ratio	chr7:910945:911978	0.08	0.07	top1	1	0.07	4.8e-06	5.2	-5.2	1.9e-07	-0.98	0.19	0.57	FALSE
80	PL	Myl6	intron excision ratio	chr7:911686:911978	0.06	0.05	lasso	2	0.06	5.2e-05	5.2	5.2	1.6e-07	0.96	0.31	0.67	FALSE
81	PL	Dnajc14	mRNA stability	ENSRNOG00000006844	0.43	0.33	top1	1	0.33	2.2e-25	5.2	-5.2	2.3e-07	-0.99	0.24	0.76	FALSE
82	PL	Dgka	mRNA stability	ENSRNOG00000022943	0.08	0.07	blup	1283	0.07	7.0e-06	5.1	5.2	2.6e-07	0.99	0.30	0.69	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.