Hub : Traits : EDL weight in grams : ←

chr15:47,167,781-49,440,043

Best TWAS P=2.060363e-11 · Best GWAS P=7.81679e-13 conditioned to 0.00411055

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Fndc3a	alternative TSS	ENSRNOT00000101367	0.05	0.02	blup	2041	0.04	2.7e-05	5.4	6.5	8.7e-11	0.84	0.69	0.30	FALSE
2	Adipose	Fndc3a	alternative TSS	ENSRNOT00000111875	0.05	0.02	blup	2041	0.03	1.4e-04	5.4	-6.5	7.9e-11	-0.84	0.55	0.42	FALSE
3	Adipose	Fndc3a	alternative TSS	ENSRNOT00000101367	0.06	0.02	blup	2041	0.04	2.1e-05	5.4	6.5	1.0e-10	0.84	0.73	0.26	FALSE
4	Adipose	Fndc3a	alternative TSS	ENSRNOT00000111875	0.05	0.02	blup	2041	0.03	1.0e-04	5.4	-6.5	8.8e-11	-0.84	0.58	0.39	FALSE
5	Adipose	Itm2b	gene expression	ENSRNOG00000016271	0.10	0.10	blup	1980	0.10	3.3e-11	5.2	5.3	9.0e-08	0.68	0.42	0.58	FALSE
6	Adipose	Fndc3a	intron excision ratio	chr15:47755611:47801368	0.04	0.02	top1	1	0.03	8.4e-04	5.4	-5.4	6.7e-08	-0.78	0.08	0.03	FALSE
7	Adipose	Fndc3a	intron excision ratio	chr15:47832616:47866529	0.03	0.01	enet	6	0.01	1.2e-02	5.4	-6.7	2.1e-11	-0.83	0.61	0.10	TRUE
8	Adipose	Rcbtb2	intron excision ratio	chr15:48333445:48336229	0.15	0.15	blup	2077	0.15	2.4e-16	5.5	5.2	1.6e-07	0.71	0.42	0.58	FALSE
9	Adipose	Rb1	mRNA stability	ENSRNOG00000016029	0.09	0.08	top1	1	0.08	1.3e-09	5.4	5.4	8.3e-08	0.71	0.36	0.64	FALSE
10	BLA	Itm2b	gene expression	ENSRNOG00000016271	0.24	0.12	top1	1	0.12	3.7e-07	5.2	5.2	1.9e-07	0.65	0.50	0.44	FALSE
11	BLA	Nudt15	gene expression	ENSRNOG00000025239	0.07	0.04	top1	1	0.04	2.2e-03	5.2	-5.2	2.0e-07	-0.69	0.09	0.05	FALSE
12	BLA	Rb1	mRNA stability	ENSRNOG00000016029	0.10	0.07	top1	1	0.07	1.5e-04	5.4	-5.4	7.4e-08	-0.68	0.09	0.06	FALSE
13	Brain	Fndc3a	gene expression	ENSRNOG00000014478	0.05	0.00	blup	2041	0.01	2.7e-02	-4.4	-5.8	5.1e-09	-0.72	0.76	0.15	FALSE
14	Brain	Med4	gene expression	ENSRNOG00000017170	0.08	0.10	top1	1	0.10	1.9e-09	5.4	-5.4	6.9e-08	-0.69	0.23	0.77	FALSE
15	Brain	Nudt15	gene expression	ENSRNOG00000025239	0.12	0.13	top1	1	0.13	1.7e-12	5.1	-5.1	3.2e-07	-0.68	0.54	0.46	FALSE
16	Brain	Itm2b	mRNA stability	ENSRNOG00000016271	0.10	0.06	lasso	3	0.07	1.1e-06	5.4	-5.4	5.5e-08	-0.62	0.54	0.46	FALSE
17	IL	Rb1	gene expression	ENSRNOG00000016029	0.19	0.05	top1	1	0.05	2.6e-02	5.1	-5.1	2.8e-07	-0.68	0.11	0.05	FALSE
18	IL	Itm2b	gene expression	ENSRNOG00000016271	0.43	0.26	top1	1	0.26	6.5e-07	5.2	5.2	2.2e-07	0.70	0.26	0.18	FALSE
19	Liver	Rcbtb2	mRNA stability	ENSRNOG00000015054	0.26	0.24	blup	2077	0.26	3.7e-28	5.6	-5.4	5.0e-08	-0.69	0.37	0.63	FALSE
20	NAcc	Itm2b	gene expression	ENSRNOG00000016271	0.32	0.23	enet	5	0.26	1.5e-06	5.2	5.4	5.7e-08	0.60	0.38	0.57	FALSE
21	NAcc2	Itm2b	gene expression	ENSRNOG00000016271	0.42	0.11	top1	1	0.11	1.0e-06	5.2	5.2	1.9e-07	0.70	0.45	0.39	FALSE
22	OFC	Rb1	gene expression	ENSRNOG00000016029	0.18	0.10	top1	1	0.10	2.6e-03	5.4	-5.4	6.7e-08	-0.69	0.11	0.06	FALSE
23	OFC	Itm2b	gene expression	ENSRNOG00000016271	0.18	0.08	top1	1	0.08	6.0e-03	5.2	5.2	2.1e-07	0.59	0.10	0.05	FALSE
24	PL2	Rb1	mRNA stability	ENSRNOG00000016029	0.44	0.05	top1	1	0.06	6.1e-04	5.5	-5.5	4.0e-08	-0.65	0.09	0.09	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.