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Locomotion velocity, session 1

Average velocity of locomotion during session 1 for males and females [meters/sec]

Tags: Behavior · Motivation · Locomotion

Project: p50_shelly_flagel_2014

3 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 4.2e-16 0.0078 5.6e-17 -890 Syt5
2 7 16845355 16970279 1 1 1.5e-46 NaN NA NA NA

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 106.7 1 1 50 0 1 NA
Body weight 6.0 2 1 50 0 1 Syt5 NA
Epididymis fat weight 87.6 1 1 50 0 1 NA
Glucose 9.3 2 0 0 0 1 Syt5 NA
Heart weight 11.4 1 0 0 0 1 NA
Left kidney weight 37.5 1 1 50 0 1 NA
Right kidney weight 28.8 2 1 50 0 1 Syt5 NA
Tail length 58.1 1 1 50 0 1 NA
Length with tail 3.2 1 0 0 0 1 NA
Length without tail 48.5 2 1 50 0 1 Syt5 NA
Liver weight, left 16.9 2 1 50 0 1 Syt5 NA
Liver weight, right 10.4 2 0 0 0 1 Syt5 NA
Parametrial fat weight 14.9 1 1 50 0 1 NA
Retroperitoneal fat weight 3.0 1 0 0 0 1 NA
Intraocular pressure 19.0 1 1 50 0 1 NA
Extensor digitorum longus weight 25.8 1 1 50 0 1 NA
Soleus weight 13.7 1 1 50 0 1 NA
Tibialis anterior weight 40.7 2 1 50 0 1 Syt5 NA
Tibia length 6.1 2 0 0 0 1 Syt5 NA
Number of licking bursts 155.0 1 1 50 0 1 NA
Food consumed during 24 hour testing period 17.5 1 0 0 0 1 NA
Times rat made contact with spout 75.1 1 1 50 0 1 NA
Mean time between licks in bursts 54.9 1 1 50 0 1 NA
Mean num. licks in bursts 164.2 1 1 50 0 1 NA
Std. dev. time between licks in bursts 126.1 2 2 100 0 1 Syt5 NA
Water consumed over 24 hours 5.7 1 0 0 0 1 NA
Indifference point 0 sec 14.6 2 1 50 0 1 Syt5 NA
Indifference point AUC 42.1 1 1 50 0 1 NA
Indifference point function ln k 6.6 2 0 0 0 1 Syt5 NA
Indifference point function log k 6.6 2 0 0 0 1 Syt5 NA
Delay discounting total patch changes 0 sec 13.7 2 1 50 0 1 Syt5 NA
Delay discounting total patch changes 12 sec 102.7 1 1 50 0 1 NA
Delay discounting total patch changes 18 sec 175.3 1 1 50 0 1 NA
Delay discounting total patch changes 24 sec 22.3 2 1 50 0 1 Syt5 NA
Delay discounting total patch changes 6 sec 98.5 1 1 50 0 1 NA
Delay discounting time to switch 0 sec 55.9 1 1 50 0 1 Syt5
Delay discounting water rate 0 sec 8.9 2 0 0 0 1 Syt5 NA
Delay discounting water rate 12 sec 24.8 2 2 100 0 1 Syt5 NA
Delay discounting water rate 18 sec 14.8 2 0 0 0 1 Syt5 NA
Delay discounting water rate 24 sec 44.5 2 1 50 0 1 Syt5 NA
Delay discounting water rate 6 sec 44.2 1 1 50 0 1 NA
Locomotor testing distance 11.5 1 0 0 0 1 NA
Locomotor testing rearing 16.8 1 1 50 0 1 NA
Light reinforcement 1 43.7 2 2 100 0 1 Syt5 NA
Light reinforcement 2 21.6 1 1 50 0 1 Syt5
Reaction time number correct 9.4 1 0 0 0 1 NA
Reaction time num false alarms 56.4 1 1 50 0 1 NA
Reaction time num false alarms AUC 56.5 2 1 50 0 1 Syt5 NA
Reaction time trials correct on left 9.4 1 0 0 0 1 NA
Reaction time trials on left 10.3 1 0 0 0 1 NA
Reaction time mean 29.2 2 1 50 0 1 Syt5 NA
Reaction time mean AUC 40.7 2 1 50 0 1 Syt5 NA
Median of all reaction times 36.5 2 1 50 0 1 Syt5 NA
Reaction time omissions 5.3 1 0 0 0 1 Syt5
Reaction time false alarm rate 43.8 2 1 50 0 1 Syt5 NA
Reaction time premature initiation rate 32.1 1 1 50 0 1 NA
Reaction time premature initiations 34.3 1 1 50 0 1 NA
Std. dev. reaction times 17.4 1 1 50 0 1 NA
Reaction time trials completed 10.3 1 0 0 0 1 NA
Reaction time trials AUC 15.6 1 0 0 0 1 NA
Social response proportion 8.0 1 0 0 0 1 Syt5
Social responses 74.3 1 1 50 0 1 NA
Social time 12.9 2 0 0 0 1 Syt5 NA
Conditioned locomotion 5.9 1 0 0 0 1 Syt5
Cocaine response after cond. corrected 58.0 2 1 50 0 1 Syt5 NA
Cocaine response after cond. not corrected 73.7 2 1 50 0 1 Syt5 NA
Cocaine response before conditioning 17.4 1 1 50 0 1 NA
Saline control response 24.6 2 1 50 0 1 Syt5 NA
Condit. Reinf. active minus inactive responses 29.4 1 1 50 0 1 NA
Condit. Reinf. active-inactive response ratio 40.7 1 1 50 0 1 NA
Condit. Reinf. active responses 11.1 1 0 0 0 1 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0 1 NA
Condit. Reinf. lever presses 9.9 1 0 0 0 1 Syt5
Pavlov. Cond. lever latency 36.3 1 1 50 0 1 NA
Pavlov. Cond. magazine entry latency 104.9 1 1 50 0 1 NA
Pavlov. Cond. change in total contacts 88.7 2 1 50 0 1 Syt5 NA
Pavlov. Cond. index score 62.2 1 1 50 0 1 NA
Pavlov. Cond. latency score 67.1 1 1 50 0 1 NA
Pavlov. Cond. lever contacts 17.2 1 1 50 0 1 NA
Pavlov. Cond. magazine entry number 150.0 1 1 50 0 1 NA
Pavlov. Cond. intertrial magazine entries 63.9 1 1 50 0 1 NA
Pavlov. Cond. lever-magazine prob. diff. 55.1 1 1 50 0 1 NA
Pavlov. Cond. response bias 30.8 1 1 50 0 1 NA
Conditioned reinforcement - actives 16.1 2 0 0 0 1 Syt5 NA
Conditioned locomotion 12.5 2 0 0 0 1 Syt5 NA
Intermittent access intake day 1-15 change 43.4 2 1 50 0 1 Syt5 NA
Intermittent access intake escalation 82.5 1 1 50 0 1 NA
Intermittent access intake escalation 2 24.7 1 1 50 0 1 NA
Intermitt. access day 1 inactive lever presses 19.3 2 1 50 0 1 Syt5 NA
Intermitt. access day 15 inactive lever presses 38.5 1 1 50 0 1 Syt5
Intermitt. access escalation Index 13.2 2 0 0 0 1 Syt5 NA
Intermittent access day 1 total infusions 32.7 1 1 50 0 1 NA
Intermittent access day 1 locomotion 18.4 1 1 50 0 1 NA
Intermittent access standard deviation 9.3 1 0 0 0 1 Syt5
Post-drug Anxiety 12.5 2 0 0 0 1 Syt5 NA
Baseline Anxiety 26.3 1 1 50 0 1 Syt5
Incentive Sensitization - Responses 6.8 1 0 0 0 1 Syt5
Incentive Sensitization - Breakpoint 8.6 1 0 0 0 1 Syt5
Progressive ratio test 1 active lever presses 11.8 1 0 0 0 1 NA
Progressive ratio test 1 breakpoint 10.4 1 0 0 0 1 NA
Progressive ratio test 1 inactive lever presses 10.8 1 0 0 0 1 NA
Progressive ratio test 2 active lever presses 12.2 1 0 0 0 1 NA
Progressive ratio test 2 breakpoint 38.7 1 1 50 0 1 NA
Short access day 1 total inactive lever presses 24.4 1 1 50 0 1 Syt5
Short access day 10 total inactive lever presses 9.1 1 0 0 0 1 NA
Short access day 10 total infusions 24.0 1 1 50 0 1 NA
Short access day 1 locomotion 11.4 1 0 0 0 1 NA
Short access day 10 total locomotion 11.2 1 0 0 0 1 Syt5
Short access total locomotion 13.1 1 0 0 0 1 Syt5
Compulsive drug intake 28.2 1 1 50 0 1 NA
One hour access (0.3 mA shock) 10.4 1 0 0 0 1 NA
One hour access (shock baseline) 24.4 1 1 50 0 1 Syt5
Number of responses in last shaping day 9.8 1 0 0 0 1 Syt5
Context. condit. distance diff. score 149.8 1 1 50 0 1 NA
Locomotion distance, session 1 257.3 2 2 100 0 1 Syt5 NA
Locomotion velocity, session 2 61.6 2 1 50 0 1 Syt5 NA
Locomotion distance, session 2 519.1 2 1 50 0 1 Syt5 NA
Locomotion velocity, session 3 116.1 1 1 50 0 1 NA
Locomotion distance, session 3 57.8 2 1 50 0 1 Syt5 NA
Stereotopy head waving bouts, day 3 8.8 1 0 0 0 1 NA
Stereotopy head waving duration, day 3 25.6 1 1 50 0 1 NA
Locomotion velocity, session 7 46.2 2 1 50 0 1 Syt5 NA
Locomotion distance, session 7 17.6 2 1 50 0 1 Syt5 NA
Stereotopy head waving bouts, day 7 42.6 1 1 50 0 1 NA
Stereotopy head waving duration, day 7 63.4 1 1 50 0 1 NA
Locomotion velocity, session 8 15.7 1 0 0 0 1 Syt5
Locomotion distance, session 8 71.6 2 1 50 0 1 Syt5 NA
Degree of sensitization distance 140.6 1 1 50 0 1 NA
Degree of sensitization stereotypy 22.9 1 1 50 0 1 NA
Condit. Reinf. active minus inactive responses 5.6 1 0 0 0 1 NA
Condit. Reinf. active-inactive response ratio 65.1 1 1 50 0 1 NA
Condit. Reinf. active responses 20.0 1 0 0 0 1 NA
Condit. Reinf. inactive responses 17.2 1 0 0 0 1 NA
Incentive salience index mean 15.6 1 0 0 0 1 NA
Condit. Reinf. lever presses 20.3 1 1 50 0 1 NA
Time in familiar zone, hab. session 1 14.6 2 0 0 0 1 Syt5 NA
Time in novel zone, hab. session 1 12.9 1 0 0 0 1 NA
Total zone transitions, hab. session 1 285.6 2 2 100 0 1 Syt5 NA
Total locomotion distance, hab. session 1 120.7 2 2 100 0 1 Syt5 NA
Locomotion velocity, hab. session 1 149.8 2 1 50 0 1 Syt5 NA
Time in familiar zone, hab. session 2 23.3 2 1 50 0 1 Syt5 NA
Time in novel zone, hab. session 2 34.1 1 1 50 0 1 NA
Total zone transitions, hab. session 2 173.3 2 1 50 0 1 Syt5 NA
Total locomotion distance, hab. session 2 92.3 2 1 50 0 1 Syt5 NA
Locomotion velocity, hab. session 2 97.5 2 1 50 0 1 Syt5 NA
Total zone transitions, NPP test 153.9 2 1 50 0 1 Syt5 NA
Total locomotion distance, NPP test 163.4 1 1 50 0 1 NA
Locomotion velocity, NPP test 195.9 1 1 50 0 1 NA
Pavlov. Cond. lever latency 8.6 1 0 0 0 1 NA
Pavlov. Cond. magazine entry latency 41.1 2 1 50 0 1 Syt5 NA
Pavlov. Cond. change in total contacts 23.1 1 1 50 0 1 NA
Pavlov. Cond. index score 28.9 1 1 50 0 1 NA
Pavlov. Cond. latency score 16.6 1 0 0 0 1 NA
Pavlov. Cond. lever contacts 13.3 1 0 0 0 1 NA
Pavlov. Cond. magazine entry number 34.9 1 1 50 0 1 NA
Pavlov. Cond. intertrial magazine entries 19.5 1 0 0 0 1 Syt5
Pavlov. Cond. lever-magazine prob. diff. 50.5 1 1 50 0 1 NA
Pavlov. Cond. response bias 24.0 2 1 50 0 1 Syt5 NA
Bone: apparent density 18.6 1 1 50 0 1 NA
Bone surface 28.9 1 1 50 0 1 NA
Bone volume 32.3 1 1 50 0 1 NA
Bone: connectivity density 8.5 1 0 0 0 1 NA
Bone: cortical porosity 109.3 1 1 50 0 1 NA
Bone: cortical porosity 63.4 2 1 50 0 1 Syt5 NA
Bone: cortical thickness 8.8 1 0 0 0 1 NA
Bone: cortical thickness 17.9 1 0 0 0 1 NA
Bone: elastic displacement 14.1 2 1 50 0 1 Syt5 NA
Bone: elastic work 5.8 1 0 0 0 1 Syt5
Bone: endosteal estimation 12.7 1 1 50 0 1 NA
Bone: final force 39.5 1 1 50 0 1 NA
Bone: final moment 31.9 1 1 50 0 1 NA
Bone: marrow area 10.6 1 1 50 0 1 NA
Bone: maximum force 42.0 1 1 50 0 1 NA
Bone: maximum moment 29.5 1 1 50 0 1 NA
Bone: minimum diameter 57.3 1 1 50 0 1 NA
Bone: periosteal estimation 7.8 1 0 0 0 1 NA
Bone: periosteal perimeter 6.4 1 0 0 0 1 NA
Bone: post-yield work 59.0 2 1 50 0 1 Syt5 NA
Bone: stiffness 61.7 2 1 50 0 1 Syt5 NA
Bone: tissue strength 58.4 2 1 50 0 1 Syt5 NA
Bone: trabecular number 39.4 1 1 50 0 1 NA
Bone: trabecular spacing 5.7 1 0 0 0 1 NA
Bone: trabecular thickness 10.4 1 0 0 0 1 NA
Bone: trabecular tissue density 31.4 2 1 50 0 1 Syt5 NA
Distance traveled before self-admin 25.7 2 1 50 0 1 Syt5 NA
Distance traveled after self-admin 56.6 1 1 50 0 1 Syt5
Delta time in open arm before/after self-admin 21.7 2 1 50 0 1 Syt5 NA
Diff in mean of infusions in LGA sessions 20.4 1 0 0 0 1 Syt5
Extinction: sum of active levers before priming 24.3 2 1 50 0 1 Syt5 NA
Active lever presses in extinction session 6 13.6 2 0 0 0 1 Syt5 NA
Delta distance traveled before/after self-admin 8.7 1 0 0 0 1 NA
Time in closed arm before self-admin 50.0 1 1 50 0 1 NA
Time in closed arm after self-admin 24.6 2 1 50 0 1 Syt5 NA
Time in open arm after self-admin 18.0 2 1 50 0 1 Syt5 NA
Sum of active levers in priming session hrs 5-6 17.2 1 0 0 0 1 Syt5
Time to tail flick, test, before self-admin 57.2 1 1 50 0 1 Syt5
Time to tail flick, test, after self-admin 5.7 1 0 0 0 1 Syt5
Delta time to tail flick, vehicle, before/after SA 8.1 2 0 0 0 1 Syt5 NA
Delta time to tail flick, test, before/after SA 31.2 2 1 50 0 1 Syt5 NA
Ambulatory time before self-admin 21.1 2 1 50 0 1 Syt5 NA
Ambulatory time after self-admin 61.3 1 1 50 0 1 Syt5
Total heroin consumption 5.8 1 0 0 0 1 Syt5
Delay disc. indifference point, 0s delay 28.0 1 1 50 0 1 Syt5
Delay disc. indifference point, 16s delay 24.1 1 0 0 0 1 Syt5
Delay disc. indifference point, 24s delay 9.6 1 0 0 0 1 Syt5
Fecal boli incidents, locomotor time 1 11.8 1 0 0 0 1 NA
Change in fecal boli incidents, locomotor task 7.5 2 0 0 0 1 Syt5 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0 0 1 NA
Bouts of movement, locomotor time 1 56.9 1 1 50 0 1 Syt5
Total resting periods, locomotor time 1 37.3 1 1 50 0 1 Syt5
Vertical activity count, locomotor time 1 24.2 1 0 0 0 1 Syt5
Time >=10cm from walls, locomotor time 2 19.4 1 1 50 0 1 NA
Total resting periods, locomotor time 2 6.0 1 0 0 0 1 NA
Rest time, locomotor task time 2 7.7 2 0 0 0 1 Syt5 NA
Distance moved, locomotor task time 2 9.3 1 0 0 0 1 NA
Vertical activity count, locomotor time 2 5.6 1 0 0 0 1 Syt5
Weight adjusted by age 13.9 2 1 50 0 1 Syt5 NA
Seeking ratio, delayed vs. immediate footshock 17.5 2 1 50 0 1 Syt5 NA
Locomotion in novel chamber 11.4 2 0 0 0 1 Syt5 NA
Progressive ratio 7.6 1 0 0 0 1 Syt5
Food seeking constrained by brief footshock 133.4 1 1 50 0 1 Syt5
Seeking ratio, punishment vs. effort 16.5 1 0 0 0 1 Syt5
Run reversals in cocaine runway, females 8.3 1 0 0 0 1 Syt5
Run reversals in cocaine runway, males 25.4 1 1 50 0 1 NA
Latency to leave start box in cocaine runway 18.8 1 0 0 0 1 NA
Cd content in liver 96.2 2 1 50 0 1 Syt5 NA
Co content in liver 61.9 2 1 50 0 1 Syt5 NA
Fe content in liver 10.3 1 0 0 0 1 NA
K content in liver 62.6 1 1 50 0 1 NA
Mn content in liver 130.2 1 1 50 0 1 NA
Rb content in liver 14.6 2 1 50 0 1 Syt5 NA
Se content in liver 47.0 1 1 50 0 1 NA
Sr content in liver 66.7 1 1 50 0 1 Syt5
Zn content in liver 21.4 2 1 50 0 1 Syt5 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.09
Adipose alternative TSS 0 0.000 1.12
Adipose gene expression 0 0.000 1.08
Adipose isoform ratio 0 0.000 1.11
Adipose intron excision ratio 0 0.000 1.09
Adipose mRNA stability 0 0.000 1.05
BLA alternative polyA 0 0.000 1.04
BLA alternative TSS 0 0.000 1.08
BLA gene expression 0 0.000 1.10
BLA isoform ratio 0 0.000 1.08
BLA intron excision ratio 0 0.000 1.05
BLA mRNA stability 1 0.049 1.12
Brain alternative polyA 0 0.000 1.01
Brain alternative TSS 0 0.000 0.99
Brain gene expression 0 0.000 1.11
Brain isoform ratio 0 0.000 1.11
Brain intron excision ratio 0 0.000 1.07
Brain mRNA stability 0 0.000 1.10
Eye alternative polyA 0 0.000 1.07
Eye alternative TSS 0 0.000 1.04
Eye gene expression 0 0.000 1.11
Eye isoform ratio 0 0.000 1.09
Eye intron excision ratio 0 0.000 1.20
Eye mRNA stability 0 0.000 1.07
IL alternative polyA 0 0.000 1.04
IL alternative TSS 0 0.000 1.03
IL gene expression 0 0.000 1.07
IL isoform ratio 0 0.000 1.06
IL intron excision ratio 0 0.000 0.98
IL mRNA stability 0 0.000 1.05
LHb alternative polyA 0 0.000 0.86
LHb alternative TSS 0 0.000 1.27
LHb gene expression 0 0.000 1.10
LHb isoform ratio 0 0.000 1.11
LHb intron excision ratio 0 0.000 0.97
LHb mRNA stability 0 0.000 1.10
Liver alternative polyA 0 0.000 1.09
Liver alternative TSS 0 0.000 1.07
Liver gene expression 0 0.000 1.08
Liver isoform ratio 0 0.000 1.09
Liver intron excision ratio 0 0.000 1.09
Liver mRNA stability 0 0.000 1.09
NAcc alternative polyA 0 0.000 1.07
NAcc alternative TSS 0 0.000 1.17
NAcc gene expression 0 0.000 1.07
NAcc isoform ratio 0 0.000 1.09
NAcc intron excision ratio 0 0.000 1.05
NAcc mRNA stability 0 0.000 1.10
OFC alternative polyA 0 0.000 1.05
OFC alternative TSS 0 0.000 0.90
OFC gene expression 0 0.000 1.08
OFC isoform ratio 0 0.000 1.08
OFC intron excision ratio 0 0.000 0.94
OFC mRNA stability 0 0.000 1.05
PL alternative polyA 0 0.000 0.99
PL alternative TSS 0 0.000 1.02
PL gene expression 0 0.000 1.06
PL isoform ratio 2 0.090 1.16
PL intron excision ratio 0 0.000 1.07
PL mRNA stability 0 0.000 1.09

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.