Hub : Traits

Median of all reaction times

Median of all reaction times for males and females [cs]

Tags: Behavior · Reaction time

Project: p50_david_dietz

3 loci · 3 genes with independent associations · 5 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr7	36928280	38299105	1	1	1.94e-07	1.62e-08	1.0e+00	Rassf9
2	chr7	40107188	41842685	3	1	1.42e-08	6.00e-09	1.0e-01	Tmtc2
3	chr19	32676171	34074113	1	1	1.70e-09	2.47e-01	5.6e-06	Zdhhc1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	3.19	2	0	0	0	1.00e+00	Mettl25 Rassf9
BMI without tail	4.09	1	0	0	0	1.00e+00	Rassf9
Body weight	2.5	1	0	0	0	1.00e+00	Rassf9
Epididymis fat weight	3.94	1	0	0	0	1.00e+00	Zdhhc1
Left kidney weight	12.42	1	1	33.3	0	1.00e+00	Zdhhc1
Right kidney weight	12.86	1	1	33.3	0	1.00e+00	Zdhhc1
Liver weight, left	7.2	1	0	0	0	1.00e+00	Mettl25
Parametrial fat weight	9.49	1	0	0	0	1.00e+00	Zdhhc1
Retroperitoneal fat weight	2.69	1	0	0	0	1.00e+00	Zdhhc1
Patch foraging indifference point AUC	7.82	1	0	0	0	1.00e+00	Zdhhc1
Patch foraging total patch changes 24 sec	6.8	1	0	0	0	1.00e+00	Zdhhc1
Patch foraging water rate 18 sec	5.97	1	0	0	0	1.00e+00	Zdhhc1
Patch foraging water rate 6 sec	6.12	1	0	0	0	1.00e+00	Zdhhc1
Locomotor activity	8.53	1	0	0	0	1.00e+00	Zdhhc1
Locomotor testing rearing	6.23	1	0	0	0	1.00e+00	Zdhhc1
Light reinforcement 1	9.77	1	0	0	0	1.00e+00	Zdhhc1
Reaction time number correct	6.58	4	0	0	-1	3.02e-04	Mettl25 Rassf9 Tmtc2 Zdhhc1
Reaction time mean minus median	5.93	1	0	0	0	1.00e+00	Rassf9
Reaction time mean minus median AUC	6.75	1	0	0	0	1.00e+00	Zdhhc1
Reaction time trials correct on left	6.58	4	0	0	-1	3.02e-04	Mettl25 Rassf9 Tmtc2 Zdhhc1
Reaction time trials on left	6.17	4	0	0	-1	3.33e-04	Mettl25 Rassf9 Tmtc2 Zdhhc1
Reaction time mean	18.67	4	1	33.3	1	3.49e-05	Mettl25 Rassf9 Tmtc2 Zdhhc1
Reaction time mean AUC	16.18	4	0	0	1	9.39e-05	Mettl25 Rassf9 Tmtc2 Zdhhc1
Reaction time omissions	10.76	1	0	0	0	1.00e+00	Rassf9
Std. dev. reaction times	8.07	4	0	0	0.98	4.06e-03	Mettl25 Rassf9 Tmtc2 Zdhhc1
Reaction time trials completed	6.17	4	0	0	-1	3.33e-04	Mettl25 Rassf9 Tmtc2 Zdhhc1
Reaction time trials AUC	5.89	4	0	0	-1	2.48e-04	Mettl25 Rassf9 Tmtc2 Zdhhc1
Social response proportion	10.93	1	0	0	0	1.00e+00	Zdhhc1
Conditioned locomotion	6.11	1	0	0	0	1.00e+00	Zdhhc1
Intermitt. access day 15 inactive lever presses	8.46	1	0	0	0	1.00e+00	Zdhhc1
Intermittent access day 1 total infusions	10.04	1	0	0	0	1.00e+00	Zdhhc1
Intermittent access day 15 total infusions	14.11	1	0	0	0	1.00e+00	Zdhhc1
Intermittent access terminal intake (last 3 days)	7.65	1	0	0	0	1.00e+00	Zdhhc1
Intermittent access total infusions	13.02	1	0	0	0	1.00e+00	Zdhhc1
Post-drug Anxiety	8.64	1	0	0	0	1.00e+00	Zdhhc1
Lifetime Intake	12.87	1	0	0	0	1.00e+00	Zdhhc1
Incentive Sensitization - Responses	29.92	1	1	33.3	0	1.00e+00	Zdhhc1
Incentive Sensitization - Breakpoint	30.58	1	1	33.3	0	1.00e+00	Zdhhc1
Progressive ratio test 1 active lever presses	11.58	1	0	0	0	1.00e+00	Zdhhc1
Progressive ratio test 2 active lever presses	26.53	1	1	33.3	0	1.00e+00	Zdhhc1
Progressive ratio test 2 breakpoint	20.83	1	0	0	0	1.00e+00	Zdhhc1
Total sessions with >9 infusions	48.24	1	1	33.3	0	1.00e+00	Zdhhc1
Short access day 10 total inactive lever presses	8.25	1	0	0	0	1.00e+00	Zdhhc1
Short access day 1 total infusions	19.14	1	0	0	0	1.00e+00	Zdhhc1
Short access day 10 total infusions	7.41	1	0	0	0	1.00e+00	Zdhhc1
Short access total infusions	8.06	1	0	0	0	1.00e+00	Zdhhc1
Compulsive drug intake	6.85	1	0	0	0	1.00e+00	Rassf9
One hour access (shock baseline)	14.65	1	0	0	0	1.00e+00	Zdhhc1
Number of responses in last shaping day	13.54	1	0	0	0	1.00e+00	Zdhhc1
Bone surface	3.9	1	0	0	0	1.00e+00	Zdhhc1
Bone volume	4.11	1	0	0	0	1.00e+00	Zdhhc1
Bone: cortical apparent density	6.16	1	0	0	0	1.00e+00	Mettl25
Bone: cortical tissue density	5.95	1	0	0	0	1.00e+00	Mettl25
Distance traveled before self-admin	50.41	1	1	33.3	0	1.00e+00	Zdhhc1
Delta time in open arm before/after self-admin	13.01	1	0	0	0	1.00e+00	Zdhhc1
Active lever presses in extinction session 6	10.03	1	0	0	0	1.00e+00	Zdhhc1
Delta ambulatory time before/after self-admin	16.57	1	0	0	0	1.00e+00	Zdhhc1
Time in closed arm before self-admin	12.8	1	0	0	0	1.00e+00	Zdhhc1
Time in closed arm after self-admin	7.24	1	0	0	0	1.00e+00	Zdhhc1
Time to tail flick, vehicle, before self-admin	18.85	1	0	0	0	1.00e+00	Zdhhc1
Ambulatory time before self-admin	34.4	1	1	33.3	0	1.00e+00	Zdhhc1
Delay disc. indifference point, 2s delay	7.52	1	0	0	0	1.00e+00	Zdhhc1
Time >=10cm from walls, locomotor time 1	16	1	0	0	0	1.00e+00	Zdhhc1
Rest time, locomotor task time 2	15.61	1	0	0	0	1.00e+00	Zdhhc1
Distance moved, locomotor task time 2	17.95	1	0	0	0	1.00e+00	Zdhhc1
Vertical activity count, locomotor time 2	11.34	1	0	0	0	1.00e+00	Zdhhc1
Progressive ratio	22.47	1	0	0	0	1.00e+00	Zdhhc1
Seeking ratio, punishment vs. effort	9.83	1	0	0	0	1.00e+00	Zdhhc1
Latency to leave start box in cocaine runway, F	9.76	1	0	0	0	1.00e+00	Zdhhc1
Latency to leave start box in cocaine runway, M	42.07	1	1	33.3	0	1.00e+00	Zdhhc1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.34
Adipose	alternative TSS	0	0	1.31
Adipose	gene expression	0	0	1.35
Adipose	isoform ratio	0	0	1.34
Adipose	intron excision ratio	0	0	1.39
Adipose	mRNA stability	1	0	1.36
BLA	alternative polyA	0	0	1.38
BLA	alternative TSS	0	0	1.37
BLA	gene expression	0	0	1.34
BLA	isoform ratio	0	0	1.38
BLA	intron excision ratio	0	0	1.43
BLA	mRNA stability	0	0	1.43
Brain	alternative polyA	0	0	1.35
Brain	alternative TSS	0	0	1.49
Brain	gene expression	0	0	1.36
Brain	isoform ratio	0	0	1.4
Brain	intron excision ratio	0	0	1.47
Brain	mRNA stability	0	0	1.37
Eye	alternative polyA	0	0	1.19
Eye	alternative TSS	0	0	1.38
Eye	gene expression	0	0	1.42
Eye	isoform ratio	0	0	1.3
Eye	intron excision ratio	0	0	1.53
Eye	mRNA stability	0	0	1.41
IL	alternative polyA	0	0	1.3
IL	alternative TSS	0	0	1.49
IL	gene expression	0	0	1.34
IL	isoform ratio	0	0	1.36
IL	intron excision ratio	0	0	1.43
IL	mRNA stability	0	0	1.44
LHb	alternative polyA	0	0	1.33
LHb	alternative TSS	0	0	1.43
LHb	gene expression	0	0	1.35
LHb	isoform ratio	1	0.1	1.38
LHb	intron excision ratio	0	0	1.54
LHb	mRNA stability	0	0	1.4
Liver	alternative polyA	0	0	1.3
Liver	alternative TSS	0	0	1.32
Liver	gene expression	0	0	1.31
Liver	isoform ratio	0	0	1.31
Liver	intron excision ratio	0	0	1.3
Liver	mRNA stability	0	0	1.31
NAcc	alternative polyA	0	0	1.37
NAcc	alternative TSS	0	0	1.42
NAcc	gene expression	1	0	1.37
NAcc	isoform ratio	0	0	1.36
NAcc	intron excision ratio	1	0	1.4
NAcc	mRNA stability	1	0	1.39
OFC	alternative polyA	0	0	1.36
OFC	alternative TSS	0	0	1.37
OFC	gene expression	0	0	1.33
OFC	isoform ratio	0	0	1.34
OFC	intron excision ratio	0	0	1.37
OFC	mRNA stability	0	0	1.44
PL	alternative polyA	0	0	1.38
PL	alternative TSS	0	0	1.44
PL	gene expression	0	0	1.37
PL	isoform ratio	0	0	1.38
PL	intron excision ratio	0	0	1.46
PL	mRNA stability	0	0	1.38
pVTA	alternative polyA	0	0	1.29
pVTA	alternative TSS	0	0	1.49
pVTA	gene expression	0	0	1.38
pVTA	isoform ratio	0	0	1.32
pVTA	intron excision ratio	0	0	1.43
pVTA	mRNA stability	0	0	1.48
RMTg	alternative polyA	0	0	1.44
RMTg	alternative TSS	0	0	1.41
RMTg	gene expression	0	0	1.36
RMTg	isoform ratio	0	0	1.3
RMTg	intron excision ratio	0	0	1.45
RMTg	mRNA stability	0	0	1.46