Hub : Genes

Gde1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000050445	0.09	0.05	3.7e-03	0.04	0.04	0.05	0.04	2.5e-03	4.4e-03	1.8e-03	5.0e-03
2	Brain	gene expression	ENSRNOG00000050445	0.17	0.07	5.7e-13	0.1	0.12	0.12	0.12	8.4e-10	6.3e-11	4.8e-11	5.7e-11
3	Liver	gene expression	ENSRNOG00000050445	0.32	0.12	0.0e+00	0.15	0.2	0.2	0.2	3.7e-16	1.5e-21	1.4e-21	4.8e-22
4	NAcc	gene expression	ENSRNOG00000050445	0.09	0.05	5.5e-04	0.05	0.02	0.02	0.03	2.3e-04	8.3e-03	6.1e-03	3.3e-03
5	PL	gene expression	ENSRNOG00000050445	0.16	0.09	6.3e-07	0.09	0.08	0.08	0.07	4.0e-07	1.0e-06	1.1e-06	4.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	2.8	9.0	12.6	2.9	3.5	-3.0	3.1	2.4
BMI without tail	7.6	15.9	22.4	3.8	4.7	-3.8	4.1	3.4
Body weight	1.9	8.1	11.3	2.4	3.4	-3.0	2.8	2.7
Epididymis fat weight	1.2	2.9	4.3	1.8	2.0	-0.7	2.1	1.6
Glucose	0.2	0.3	0.7	0.6	0.2	0.6	0.2	0.9
Heart weight	0.2	0.2	0.6	0.4	0.0	0.5	0.2	0.8
Left kidney weight	2.5	7.1	8.8	2.5	3.0	-2.9	2.2	2.6
Right kidney weight	2.9	8.1	10.4	2.6	3.2	-3.2	2.3	2.9
Tail length	2.0	6.1	8.0	2.2	2.8	-2.3	2.3	2.8
Length with tail	0.2	0.9	1.7	0.5	1.0	-1.1	0.6	1.3
Length without tail	1.1	2.4	3.4	-1.8	-1.8	1.0	-1.8	-1.2
Liver weight, left	0.4	0.6	1.3	0.7	0.9	-0.3	1.2	0.5
Liver weight, right	0.4	0.7	1.3	0.4	1.1	-1.0	1.1	-0.3
Parametrial fat weight	3.0	5.8	7.5	2.7	2.6	-1.5	2.4	2.7
Retroperitoneal fat weight	1.3	4.3	7.4	2.3	2.0	0.6	2.7	2.1
Intraocular pressure	0.2	0.3	0.6	0.3	0.6	-0.5	0.8	0.4
Extensor digitorum longus weight	2.0	7.9	27.3	1.2	2.7	-5.2	0.9	1.7
Soleus weight	1.5	4.2	7.0	1.8	2.0	-2.3	1.2	2.6
Tibialis anterior weight	4.1	14.2	25.7	2.9	4.1	-5.1	2.5	3.8
Tibia length	0.1	0.2	0.6	0.4	-0.0	0.4	0.1	0.8
Number of licking bursts	6.9	8.2	11.9	-2.4	-3.4	1.8	-3.3	-3.0
Food consumed during 24 hour testing period	0.9	1.1	2.8	0.6	1.0	-1.7	0.4	1.0
Times rat made contact with spout	0.8	1.0	4.3	-0.3	0.2	-2.1	-0.7	-0.0
Mean time between licks in bursts	0.1	0.2	0.7	-0.3	-0.2	-0.1	-0.1	-0.8
Mean num. licks in bursts	6.0	7.2	9.9	2.0	3.1	-2.8	2.5	2.8
Std. dev. time between licks in bursts	0.2	0.3	0.5	0.5	0.6	-0.4	0.7	-0.2
Water consumed over 24 hours	3.3	3.9	6.4	-2.1	-2.1	-0.3	-2.5	-2.1
Indifference point 0 sec	1.7	2.7	4.0	1.8	1.5	0.1	2.0	2.0
Indifference point AUC	0.7	0.8	1.3	1.0	0.8	-1.0	0.5	1.1
Indifference point function ln k	0.2	0.2	0.3	0.4	0.6	-0.2	0.6	0.6
Indifference point function log k	0.2	0.2	0.3	0.4	0.6	-0.2	0.6	0.6
Delay discounting total patch changes 0 sec	2.0	3.2	4.8	2.0	1.6	0.2	2.2	2.1
Delay discounting total patch changes 12 sec	0.4	0.6	0.9	0.8	0.8	-0.5	0.9	0.7
Delay discounting total patch changes 18 sec	0.1	0.1	0.3	0.5	-0.1	0.2	0.1	0.5
Delay discounting total patch changes 24 sec	1.5	1.8	2.8	1.6	1.3	-0.4	1.4	1.7
Delay discounting total patch changes 6 sec	1.1	1.7	3.4	1.4	0.4	1.4	1.1	1.8
Delay discounting time to switch 0 sec	2.8	4.2	7.9	-2.4	-1.9	0.9	-1.7	-2.8
Delay discounting water rate 0 sec	0.3	0.5	0.8	0.9	0.8	-0.4	0.7	0.7
Delay discounting water rate 12 sec	2.3	3.4	5.7	2.1	1.8	-0.3	1.9	2.4
Delay discounting water rate 18 sec	0.9	1.2	1.9	1.2	1.1	0.3	1.4	1.2
Delay discounting water rate 24 sec	0.4	0.5	1.2	0.7	0.7	-0.5	0.2	1.1
Delay discounting water rate 6 sec	0.2	0.3	0.8	0.8	0.1	0.4	0.0	0.9
Locomotor activity	0.1	0.2	0.7	0.3	0.5	-0.1	0.8	0.2
Locomotor testing distance	0.6	1.0	1.7	1.1	1.0	-0.3	1.3	1.0
Locomotor testing rearing	0.4	0.6	1.6	0.6	0.7	0.3	1.3	0.4
Light reinforcement 1	0.3	0.5	1.2	0.4	0.5	0.8	1.1	0.4
Light reinforcement 2	0.6	0.7	1.6	0.8	0.8	0.5	1.3	0.7
Reaction time number correct	0.4	0.5	1.4	-0.5	-0.6	1.2	-0.1	-0.8
Reaction time mean minus median	0.1	0.1	0.3	0.6	0.3	-0.3	0.0	0.3
Reaction time mean minus median AUC	0.3	0.3	0.6	0.8	0.3	0.7	0.4	0.4
Reaction time num false alarms	1.5	2.1	3.6	-1.3	-1.8	0.3	-1.9	-1.2
Reaction time num false alarms AUC	1.0	1.4	2.2	-1.1	-1.4	0.3	-1.5	-1.2
Reaction time trials correct on left	0.4	0.5	1.4	-0.5	-0.6	1.2	-0.1	-0.8
Reaction time trials on left	0.4	0.5	1.4	-0.4	-0.6	1.2	-0.0	-0.8
Reaction time mean	0.5	0.7	1.1	1.1	1.0	-0.3	0.8	0.8
Reaction time mean AUC	0.3	0.4	0.6	0.7	0.8	-0.1	0.7	0.5
Median of all reaction times	0.5	0.7	1.1	1.0	1.0	-0.4	0.9	0.7
Reaction time omissions	0.2	0.3	0.8	-0.2	-0.1	0.6	0.2	-0.9
Reaction time false alarm rate	0.8	1.1	2.3	-1.0	-1.1	-0.5	-1.5	-0.8
Reaction time premature initiation rate	0.6	0.8	3.5	0.1	0.6	-1.9	-0.0	0.5
Reaction time premature initiations	0.2	0.3	1.1	-0.4	0.1	-1.1	-0.2	-0.2
Std. dev. reaction times	0.4	0.6	1.0	1.0	0.8	-0.2	0.7	0.9
Reaction time trials completed	0.4	0.5	1.4	-0.4	-0.6	1.2	-0.0	-0.8
Reaction time trials AUC	0.2	0.3	1.0	-0.3	-0.4	1.0	0.0	-0.6
Social response proportion	0.5	0.5	1.0	0.7	0.4	1.0	0.9	0.3
Social responses	0.3	0.4	1.3	-0.1	-0.3	1.1	0.2	-0.7
Social time	0.7	0.9	2.5	-0.7	-1.0	1.6	-0.5	-0.6
Conditioned locomotion	1.0	1.2	2.4	-1.5	-0.9	0.0	-0.9	-1.6
Cocaine response after cond. corrected	0.3	0.3	0.5	-0.5	-0.7	0.4	-0.7	-0.5
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.1	-0.0	-0.4	-0.2	-0.0
Cocaine response before conditioning	1.1	1.4	3.7	0.6	1.3	-1.9	0.7	0.8
Saline control response	0.1	0.2	0.3	0.4	0.1	0.6	0.5	0.3
Condit. Reinf. active minus inactive responses	2.0	2.5	4.4	1.9	1.7	0.0	2.1	1.4
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.7	1.5	1.0	0.7	1.6	1.0
Condit. Reinf. active responses	1.2	1.6	2.8	1.4	1.5	-0.3	1.7	1.1
Condit. Reinf. inactive responses	0.4	0.5	1.9	0.0	0.7	-1.4	0.3	0.2
Condit. Reinf. lever presses	1.9	2.6	3.8	1.7	1.9	-1.0	1.9	1.3
Condit. Reinf. lever reinforcers received	0.9	1.2	2.5	1.2	1.2	0.1	1.6	0.8
Pavlov. Cond. lever latency	1.1	1.5	2.1	-1.3	-1.5	0.7	-1.4	-1.1
Pavlov. Cond. magazine entry latency	1.8	2.1	3.9	-1.6	-1.4	0.7	-1.3	-2.0
Pavlov. Cond. change in total contacts	0.9	1.2	1.6	1.3	0.7	1.1	1.2	1.1
Pavlov. Cond. index score	0.0	0.1	0.1	0.2	0.1	0.3	0.3	-0.3
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	0.1	0.1	0.1	-0.3
Pavlov. Cond. lever contacts	1.3	1.9	2.7	1.5	1.6	-0.8	1.6	1.1
Pavlov. Cond. magazine entry number	1.5	1.8	2.5	1.1	1.4	-1.6	1.0	1.5
Pavlov. Cond. intertrial magazine entries	2.9	3.7	5.2	1.9	2.3	-1.8	2.0	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.0	-0.1	0.5	0.1	-0.5
Pavlov. Cond. response bias	0.3	0.3	0.7	0.7	0.7	0.1	0.8	0.2
Conditioned reinforcement - actives	0.3	0.3	1.0	0.5	0.6	0.1	0.3	1.0
Conditioned reinforcement - inactives	0.4	0.4	0.8	-0.4	-0.6	0.7	-0.9	-0.4
Conditioned locomotion	0.1	0.2	0.3	-0.6	-0.2	0.4	-0.4	-0.2
Intermittent access intake day 1-15 change	2.5	2.5	3.8	-1.6	-1.8	0.3	-1.9	-1.8
Intermittent access intake escalation	2.0	1.9	3.0	-1.3	-1.6	0.2	-1.7	-1.5
Intermittent access intake escalation 2	2.7	2.7	3.6	-1.9	-1.8	0.2	-1.9	-1.7
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	-0.4	-0.5	0.1	-0.6	-0.2
Intermitt. access day 15 inactive lever presses	0.2	0.3	1.2	-0.1	0.4	-1.1	-0.2	-0.0
Intermitt. access escalation Index	0.5	0.5	0.6	0.7	0.7	-0.8	0.6	0.6
Intermittent access day 1 total infusions	2.6	2.9	4.0	1.9	2.0	-0.3	1.8	1.9
Intermittent access day 15 total infusions	0.2	0.2	0.4	0.6	0.4	0.1	0.2	0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.3	0.6	0.5	0.1	0.4	0.6
Intermittent access total infusions	1.5	1.6	2.4	1.4	1.5	-0.2	1.3	1.5
Intermittent access day 1 locomotion	3.2	3.3	5.2	2.3	2.0	-0.2	1.8	1.9
Intermittent access day 15 total locomotion	0.8	0.8	3.5	0.7	-0.2	1.9	0.2	0.4
Intermittent access total locomotion	2.7	3.0	5.5	2.3	1.7	0.5	1.9	1.7
Intermittent access standard deviation	0.2	0.2	0.6	-0.8	-0.1	-0.5	-0.5	-0.2
Cocaine induced anxiety	0.1	0.1	0.2	0.4	-0.1	0.2	-0.1	-0.4
Post-drug Anxiety	0.2	0.2	0.7	0.4	-0.2	0.8	0.0	0.3
Baseline Anxiety	0.3	0.3	1.2	0.0	0.4	-0.2	0.2	1.1
Lifetime Intake	2.5	2.8	4.1	1.7	2.0	-0.5	1.7	1.9
Incentive Sensitization - Responses	0.1	0.1	0.3	0.1	0.6	0.3	0.5	0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.2	0.6	0.3	0.6	0.4
Progressive ratio test 1 active lever presses	1.3	1.4	2.6	1.6	1.4	-0.0	1.2	1.0
Progressive ratio test 1 breakpoint	1.2	1.2	2.2	1.5	1.3	0.0	1.1	1.0
Progressive ratio test 1 inactive lever presses	0.9	0.9	2.1	1.5	1.1	-0.5	0.7	0.7
Progressive ratio test 2 active lever presses	0.9	1.0	1.6	1.0	1.3	0.2	1.1	1.1
Progressive ratio test 2 breakpoint	0.9	1.0	1.6	1.0	1.2	0.3	1.1	1.1
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.3	1.1	0.9	0.4	0.9	0.8
Total sessions with >9 infusions	3.7	4.1	6.4	1.8	2.5	-2.0	1.6	2.1
Short access day 1 total inactive lever presses	0.2	0.2	0.4	0.5	0.5	0.3	0.4	0.7
Short access day 10 total inactive lever presses	0.9	1.0	1.5	-0.9	-1.2	0.7	-1.2	-0.9
Short access day 1 total infusions	1.9	2.1	3.3	1.1	1.8	-0.5	1.5	1.8
Short access day 10 total infusions	1.7	1.9	2.9	1.6	1.7	-1.0	1.1	1.3
Short access total infusions	3.9	4.3	6.2	2.1	2.5	-0.9	2.1	2.4
Short access day 1 locomotion	0.3	0.3	0.7	0.4	0.7	-0.0	0.5	0.8
Short access day 10 total locomotion	3.1	3.4	5.0	2.2	2.2	-1.1	1.9	1.6
Short access total locomotion	5.3	5.4	7.2	2.6	2.6	-0.2	2.5	2.7
Compulsive drug intake	1.0	1.0	2.0	1.0	1.0	-0.1	1.4	0.9
One hour access (0.3 mA shock)	3.4	4.0	5.9	2.4	2.3	-0.9	2.1	1.9
One hour access (shock baseline)	0.1	0.1	0.3	0.3	-0.0	0.5	-0.2	0.1
Number of responses in last shaping day	0.6	0.6	1.1	0.6	1.1	-0.7	0.7	0.8
Context. condit. distance diff. score	0.2	0.2	0.9	-0.1	-0.2	1.0	0.1	-0.4
Locomotion velocity, session 1	0.1	0.1	0.4	-0.5	-0.3	-0.1	-0.6	-0.0
Locomotion distance, session 1	1.1	1.4	2.0	1.1	1.4	-0.7	1.4	1.3
Locomotion velocity, session 2	0.3	0.3	0.7	-0.8	-0.7	0.2	-0.7	-0.2
Locomotion distance, session 2	1.1	1.6	2.6	1.0	1.4	-1.6	0.9	1.4
Locomotion velocity, session 3	0.2	0.2	0.3	0.2	0.6	-0.5	0.6	0.6
Locomotion distance, session 3	0.4	0.5	1.1	-0.8	-0.2	-1.1	-0.5	-0.6
Stereotopy head waving bouts, day 3	0.2	0.3	1.3	-0.1	-0.4	1.1	0.1	-0.0
Stereotopy head waving duration, day 3	0.2	0.3	1.1	0.2	-0.1	1.0	0.4	0.3
Locomotion velocity, session 7	0.6	0.6	2.5	-0.1	0.7	-1.6	0.2	-0.1
Locomotion distance, session 7	0.5	0.6	0.8	-0.9	-0.5	-0.7	-0.8	-0.9
Stereotopy head waving bouts, day 7	0.4	0.5	0.8	0.6	0.7	-0.1	0.9	0.9
Stereotopy head waving duration, day 7	1.7	2.1	2.9	1.3	1.7	-1.1	1.7	1.3
Locomotion velocity, session 8	0.0	0.0	0.1	0.0	0.1	-0.1	-0.0	0.3
Locomotion distance, session 8	0.1	0.2	0.4	0.4	0.6	-0.3	0.5	0.4
Degree of sensitization distance	0.4	0.4	0.7	0.8	0.1	0.9	0.3	0.7
Degree of sensitization stereotypy	1.1	1.2	1.5	0.8	1.2	-1.1	1.1	1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	0.3	0.2	0.6	0.3	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.3	0.5	0.3	0.5	-0.0
Condit. Reinf. active responses	0.1	0.1	0.3	0.2	0.1	0.6	0.2	0.1
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	-0.0	0.2	0.1	0.2
Incentive salience index mean	0.0	0.0	0.1	0.0	0.3	-0.2	0.0	-0.3
Condit. Reinf. lever presses	0.3	0.4	1.1	-0.6	-0.2	-0.4	-0.4	-1.1
Time in familiar zone, hab. session 1	0.4	0.4	1.0	0.2	-0.6	1.0	-0.6	0.3
Time in novel zone, hab. session 1	0.5	0.5	0.9	-0.3	0.7	-1.0	0.8	-0.2
Total zone transitions, hab. session 1	2.2	3.2	5.1	1.8	1.9	-1.5	1.3	2.3
Total locomotion distance, hab. session 1	5.9	8.5	12.1	3.0	3.2	-2.2	2.5	3.5
Locomotion velocity, hab. session 1	5.5	7.9	10.4	3.0	3.1	-1.9	2.6	3.2
Time in familiar zone, hab. session 2	0.3	0.3	0.4	0.7	0.5	-0.6	0.2	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.0	0.1	0.4	0.4	-0.0
Total zone transitions, hab. session 2	2.4	3.1	4.5	1.8	2.0	-1.2	1.6	2.1
Total locomotion distance, hab. session 2	3.1	4.1	6.4	2.0	2.1	-1.6	1.6	2.5
Locomotion velocity, hab. session 2	3.4	4.6	6.5	2.2	2.3	-1.9	1.7	2.5
Novel to familiar place preference ratio	0.6	0.6	1.1	-0.5	-1.0	0.8	-1.0	-0.5
Novelty place preference	0.9	0.9	1.7	-0.7	-1.2	0.7	-1.3	-0.6
Time in novel zone, NPP test	0.5	0.6	0.9	-0.4	-1.0	0.8	-0.9	-0.4
Total zone transitions, NPP test	1.4	2.0	2.9	1.3	1.6	-1.3	1.2	1.7
Total locomotion distance, NPP test	1.5	2.1	3.5	1.4	1.4	-1.4	0.9	1.9
Locomotion velocity, NPP test	1.1	1.6	2.8	1.2	1.2	-1.3	0.7	1.7
Pavlov. Cond. lever latency	0.7	0.9	2.1	-0.1	-1.0	1.5	-0.7	0.8
Pavlov. Cond. magazine entry latency	2.1	2.7	4.6	1.2	2.1	-2.1	1.8	0.1
Pavlov. Cond. change in total contacts	1.1	1.2	3.5	-0.7	0.4	-1.9	-0.1	-1.4
Pavlov. Cond. index score	1.1	1.4	3.1	0.4	1.4	-1.7	1.1	-0.8
Pavlov. Cond. latency score	1.0	1.3	2.7	0.5	1.4	-1.6	1.2	-0.6
Pavlov. Cond. lever contacts	1.1	1.3	3.5	0.2	1.2	-1.9	0.8	-0.9
Pavlov. Cond. magazine entry number	0.9	1.2	3.4	-0.0	-1.1	1.8	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.6	0.8	3.1	0.0	-0.7	1.8	-0.1	0.5
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	3.8	0.6	1.6	-2.0	1.3	-0.6
Pavlov. Cond. response bias	1.1	1.4	4.1	-0.2	1.0	-2.0	0.5	-1.2
Bone: apparent density	0.8	1.3	1.7	1.1	1.3	-1.1	0.9	1.3
Bone surface	0.5	0.9	2.5	0.5	1.1	-1.6	0.5	0.7
Bone volume	1.1	1.9	3.2	1.1	1.5	-1.8	0.9	1.3
Bone: connectivity density	0.4	0.7	1.1	0.7	1.1	-0.9	0.8	0.5
Bone: cortical apparent density	0.7	1.0	1.4	-1.0	-1.2	0.8	-1.1	-0.7
Bone: cortical area	2.2	3.4	5.5	1.5	2.0	-2.4	1.2	1.9
Bone: cortical porosity	1.3	1.4	2.4	1.2	1.4	-0.6	1.5	0.9
Bone: cortical porosity	0.9	0.9	2.1	0.9	1.1	-0.1	1.4	0.6
Bone: cortical thickness	0.9	1.5	3.1	1.0	1.0	-1.5	0.4	1.8
Bone: cortical thickness	0.3	0.4	1.3	0.1	-0.2	-0.3	-0.6	1.1
Bone: cortical tissue density	0.7	1.0	1.3	-1.0	-1.2	0.8	-1.1	-0.7
Bone: elastic displacement	0.3	0.3	1.2	-0.1	-0.5	1.1	-0.3	0.3
Bone: elastic work	0.2	0.2	0.6	0.3	0.5	-0.4	0.2	0.7
Bone: endosteal estimation	1.1	2.3	4.9	1.0	1.8	-2.2	1.3	0.7
Bone: endosteal perimeter	0.5	1.0	4.1	0.2	0.8	-2.0	0.2	-0.2
Bone: final force	3.9	6.4	9.9	2.1	2.8	-3.1	1.9	2.4
Bone: final moment	3.6	5.9	7.5	2.1	2.7	-2.7	2.0	2.5
Bone: marrow area	0.9	2.0	4.4	0.9	1.7	-2.1	1.2	0.6
Bone: maximum diameter	1.5	2.8	4.7	1.4	1.9	-2.2	1.4	1.4
Bone: maximum force	2.9	5.0	8.6	1.8	2.5	-2.9	1.5	2.2
Bone: maximum moment	2.6	4.5	6.2	1.8	2.4	-2.5	1.6	2.2
Bone: minimum diameter	1.1	2.0	4.8	1.0	1.6	-2.2	1.0	0.9
Bone: periosteal estimation	2.0	4.2	8.3	1.5	2.3	-2.9	1.5	1.6
Bone: periosteal perimeter	1.1	1.9	3.2	1.1	1.6	-1.8	1.3	0.9
Bone: post-yield work	3.6	4.9	7.0	2.4	2.7	-1.2	2.6	1.9
Bone: stiffness	1.9	3.0	6.8	1.3	1.7	-2.6	0.7	1.7
Bone: tissue strength	0.1	0.1	0.3	-0.4	-0.2	-0.3	-0.5	-0.2
Bone: trabecular number	0.4	0.7	0.9	0.8	0.8	-0.9	0.5	1.0
Bone: trabecular spacing	0.5	0.6	2.0	-0.6	-0.5	0.7	-0.0	-1.4
Bone: trabecular thickness	4.0	4.8	9.6	2.5	2.1	-0.6	1.9	3.1
Bone: trabecular tissue density	0.0	0.0	0.1	-0.0	-0.2	-0.0	-0.2	0.2
Breakpoint value in progressive ratio session	0.8	0.9	4.1	-0.1	-0.5	2.0	0.2	-0.2
Distance traveled before self-admin	0.1	0.1	0.6	-0.0	-0.2	-0.1	-0.8	0.1
Distance traveled after self-admin	0.8	0.9	3.0	0.5	0.7	-1.7	-0.1	0.7
Delta time in closed arm before/after self-admin	1.0	1.0	2.5	-1.6	-0.7	-0.3	-0.7	-1.2
Delta time in open arm before/after self-admin	3.5	3.3	5.7	2.4	1.7	-1.2	1.6	2.0
Diff in mean of infusions in LGA sessions	0.8	0.9	2.3	1.3	0.0	1.5	0.5	0.5
Extinction: sum of active levers before priming	0.4	0.4	0.6	-0.6	-0.7	0.4	-0.6	-0.7
Active lever presses in extinction session 6	0.4	0.4	0.8	0.6	0.4	0.9	0.6	0.3
Delta distance traveled before/after self-admin	0.9	1.0	1.7	0.7	1.2	-1.3	1.0	0.7
Delta ambulatory time before/after self-admin	0.7	0.8	1.6	0.6	0.9	-1.2	0.7	0.7
Time in closed arm before self-admin	0.9	1.0	1.9	1.4	1.2	-0.6	0.7	1.1
Time in closed arm after self-admin	0.4	0.5	1.8	-0.3	-0.5	1.4	-0.2	0.1
Time in open arm before self-admin	2.2	2.4	3.7	-1.9	-1.7	1.2	-1.2	-1.7
Time in open arm after self-admin	0.8	0.9	3.3	0.8	0.7	-1.8	0.3	0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	0.3	0.4	0.4	0.9	0.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.8	-0.5	-0.0	-0.9	-0.0	0.1
Time to tail flick, vehicle, after self-admin	1.0	1.1	1.6	-1.1	-0.8	1.2	-0.6	-1.2
Time to tail flick, test, before self-admin	0.5	0.5	0.7	-0.7	-0.6	-0.8	-0.8	-0.5
Time to tail flick, test, after self-admin	2.5	2.6	5.2	-1.7	-1.4	0.0	-1.7	-2.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	0.2	0.3	0.8	0.4	-0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.7	-0.2	-0.0	0.1	-0.2	-0.8
Ambulatory time before self-admin	0.2	0.2	0.8	-0.1	-0.2	0.2	-0.9	0.2
Ambulatory time after self-admin	0.8	0.9	3.1	0.6	0.7	-1.8	-0.2	0.8
Total heroin consumption	0.5	0.6	2.0	0.5	0.4	1.4	0.7	-0.0
Area under the delay curve	0.4	0.4	0.7	-0.8	-0.8	0.6	-0.7	-0.1
Delay disc. indifference point, 0s delay	0.5	0.6	1.5	-0.4	-0.3	-1.2	-1.1	-0.1
Delay disc. indifference point, 16s delay	3.2	3.3	7.4	-1.5	-2.1	2.7	-1.2	-1.0
Delay disc. indifference point, 2s delay	2.2	2.4	5.6	1.3	1.5	-2.4	0.8	1.5
Delay disc. indifference point, 24s delay	3.8	3.6	4.6	-1.9	-2.1	2.1	-1.7	-1.6
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.4	-0.5	0.1	-0.7	0.6
Delay disc. indifference point, 8s delay	0.4	0.4	0.9	-0.9	-0.6	-0.0	-0.8	-0.1
Delay discount exponential model param	0.4	0.4	0.7	0.8	0.8	-0.6	0.6	0.2
Delay discount hyperbolic model param	0.2	0.2	0.3	0.6	0.6	-0.3	0.5	-0.1
Fecal boli incidents, locomotor time 1	0.4	0.5	1.3	-0.3	0.0	0.9	0.3	-1.1
Change in fecal boli incidents, locomotor task	1.9	1.8	5.4	1.0	0.9	0.3	1.2	2.3
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	0.6	0.6	-0.9	0.1	0.4
Bouts of movement, locomotor time 1	1.7	1.9	3.0	-0.8	-1.5	1.7	-0.9	-1.7
Total resting periods, locomotor time 1	2.3	2.6	3.7	-1.3	-1.7	1.9	-1.0	-1.9
Rest time, locomotor task time 1	2.9	3.1	5.7	-2.4	-1.6	0.5	-2.0	-1.8
Distance moved, locomotor task time 1	3.5	3.8	6.2	2.5	1.7	-1.1	2.0	2.2
Vertical activity count, locomotor time 1	3.0	3.1	4.8	2.2	1.4	-1.9	1.0	2.1
Time >=10cm from walls, locomotor time 2	1.0	1.1	3.1	0.5	1.2	-1.8	0.0	0.9
Bouts of movement, locomotor time 2	0.5	0.5	1.1	0.3	0.7	-0.8	0.6	-1.1
Total resting periods, locomotor time 2	0.6	0.6	0.9	0.5	0.9	-0.9	0.8	-0.8
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.1	0.2	0.4	0.2	0.4
Distance moved, locomotor task time 2	0.5	0.6	2.0	-0.0	-0.1	-1.4	-0.9	-0.0
Vertical activity count, locomotor time 2	0.5	0.5	1.3	0.3	0.1	-1.2	-0.8	0.7
Weight adjusted by age	0.9	1.0	1.9	1.3	1.2	-0.5	1.4	0.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.5	0.3	0.0	0.0	0.1
Locomotion in novel chamber	2.1	2.6	4.3	2.1	1.9	-0.1	1.8	1.4
Locomotion in novel chamber post-restriction	1.0	1.2	1.7	1.2	0.6	1.1	1.3	1.0
Progressive ratio	0.5	0.5	1.0	0.7	0.4	0.7	0.7	1.0
Food seeking constrained by brief footshock	1.1	1.4	2.2	-0.9	-1.5	1.5	-1.2	-0.7
Seeking ratio, punishment vs. effort	0.2	0.2	0.6	-0.3	-0.2	-0.4	-0.4	-0.8
Run reversals in cocaine runway, females	3.1	3.0	7.5	1.2	1.6	-2.7	0.8	1.7
Run reversals in cocaine runway, males	0.5	0.5	1.0	-0.5	-0.9	0.4	-1.0	-0.6
Latency to leave start box in cocaine runway	0.5	0.6	1.2	0.6	0.2	1.1	0.7	0.9
Latency to leave start box in cocaine runway, F	0.1	0.1	0.5	-0.0	-0.0	0.7	0.4	-0.2
Latency to leave start box in cocaine runway, M	0.7	0.6	1.7	0.5	-0.0	1.1	0.3	1.3
Cd content in liver	2.1	2.3	9.6	-0.3	-1.3	3.1	-0.1	-0.5
Co content in liver	0.5	0.5	1.7	0.1	-0.4	1.3	0.1	0.9
Cu content in liver	1.0	1.2	2.4	1.4	0.9	0.0	1.0	1.5
Fe content in liver	0.7	0.9	1.6	-0.6	-1.3	1.0	-1.2	-0.3
K content in liver	0.2	0.2	0.3	0.5	0.5	-0.1	0.6	0.2
Mg content in liver	0.3	0.3	0.9	0.3	0.5	0.3	1.0	-0.4
Mn content in liver	0.2	0.2	0.7	-0.4	0.2	-0.8	-0.2	-0.4
Na content in liver	2.2	2.3	9.0	0.3	1.5	-3.0	0.5	0.1
Rb content in liver	1.3	1.6	3.6	0.9	0.4	1.9	1.3	1.4
Se content in liver	0.2	0.2	0.4	-0.2	-0.2	-0.6	-0.5	-0.4
Sr content in liver	0.5	0.4	0.8	0.7	0.8	-0.9	0.5	0.4
Zn content in liver	2.6	2.9	4.0	1.7	2.0	-1.9	1.7	1.1