Hub : Genes

Ctsw

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000027096	0.09	0.05	2.2e-06	0.05	0.06	0.05	0.05	1.4e-05	1.7e-06	9.1e-06	1.8e-05
2	Liver	gene expression	ENSRNOG00000027096	0.16	0.09	7.1e-03	0.01	0.01	0	0.01	5.0e-02	4.2e-02	2.3e-01	3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	3.1	9.9	10.8	3.3	-3.0
BMI without tail	1.2	2.5	2.6	1.6	-1.6
Body weight	4.3	18.3	18.5	4.3	-4.3
Epididymis fat weight	2.9	6.7	7.2	-2.5	2.7
Glucose	1.9	2.9	3.3	-1.6	1.8
Heart weight	4.2	6.1	6.4	-2.4	2.5
Left kidney weight	0.6	1.8	1.8	-1.3	1.3
Right kidney weight	0.1	0.2	0.2	-0.3	0.5
Tail length	0.5	1.4	2.0	0.9	-1.4
Length with tail	2.2	8.2	9.0	2.7	-3.0
Length without tail	3.0	6.4	6.6	2.6	-2.5
Liver weight, left	0.1	0.1	0.1	-0.3	0.2
Liver weight, right	0.1	0.2	0.2	-0.5	0.3
Parametrial fat weight	2.1	4.0	4.2	-2.0	2.1
Retroperitoneal fat weight	5.8	19.2	20.2	-4.3	4.5
Intraocular pressure	0.7	1.0	1.1	-0.9	1.1
Extensor digitorum longus weight	8.4	33.9	34.3	5.8	-5.9
Soleus weight	4.9	14.4	14.9	-3.9	3.7
Tibialis anterior weight	12.0	41.4	42.7	6.3	-6.5
Tibia length	1.4	3.9	4.6	2.1	-1.8
Number of licking bursts	0.5	0.5	0.6	0.8	-0.7
Food consumed during 24 hour testing period	0.0	0.1	0.1	0.3	-0.2
Times rat made contact with spout	0.4	0.5	0.5	0.7	-0.7
Mean time between licks in bursts	0.4	0.6	1.0	0.4	-1.0
Mean num. licks in bursts	0.3	0.4	0.4	-0.6	0.6
Std. dev. time between licks in bursts	0.2	0.2	0.5	-0.7	0.1
Water consumed over 24 hours	0.8	1.0	1.0	1.0	-1.0
Indifference point 0 sec	0.0	0.0	0.0	-0.1	0.1
Indifference point AUC	4.6	5.4	5.6	2.4	-2.3
Indifference point function ln k	11.0	15.6	16.8	-4.1	3.8
Indifference point function log k	11.0	15.6	16.8	-4.1	3.8
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	-0.2	0.0
Delay discounting total patch changes 12 sec	6.2	8.2	8.2	2.9	-2.9
Delay discounting total patch changes 18 sec	0.9	1.1	1.3	1.1	-1.0
Delay discounting total patch changes 24 sec	3.0	3.8	4.0	1.9	-2.0
Delay discounting total patch changes 6 sec	1.3	1.9	2.0	1.4	-1.4
Delay discounting time to switch 0 sec	2.4	3.7	4.3	2.1	-1.8
Delay discounting water rate 0 sec	4.8	7.6	8.5	-2.9	2.6
Delay discounting water rate 12 sec	11.5	17.3	19.0	-4.4	3.9
Delay discounting water rate 18 sec	4.6	6.0	6.7	-2.6	2.3
Delay discounting water rate 24 sec	5.8	8.0	8.8	-3.0	2.7
Delay discounting water rate 6 sec	5.4	7.8	8.8	-3.0	2.6
Locomotor activity	2.5	3.9	4.4	-2.1	1.9
Locomotor testing distance	3.7	6.1	6.8	-2.6	2.3
Locomotor testing rearing	3.0	4.8	5.0	-2.2	2.1
Light reinforcement 1	0.2	0.3	0.4	-0.6	0.5
Light reinforcement 2	0.8	1.1	1.5	-0.9	1.2
Reaction time number correct	0.2	0.3	0.3	0.5	-0.6
Reaction time mean minus median	4.3	5.6	6.3	2.5	-2.2
Reaction time mean minus median AUC	2.2	2.8	3.0	1.7	-1.6
Reaction time num false alarms	0.4	0.6	0.9	-1.0	0.4
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.2	-0.2
Reaction time trials correct on left	0.2	0.3	0.3	0.5	-0.6
Reaction time trials on left	0.3	0.4	0.5	0.6	-0.7
Reaction time mean	0.1	0.2	0.2	0.4	-0.4
Reaction time mean AUC	0.1	0.2	0.2	0.4	-0.4
Median of all reaction times	0.0	0.0	0.0	-0.0	-0.0
Reaction time omissions	1.5	2.0	2.2	1.5	-1.3
Reaction time false alarm rate	0.3	0.4	0.6	-0.8	0.4
Reaction time premature initiation rate	2.2	2.9	3.7	1.5	-1.9
Reaction time premature initiations	3.5	5.0	5.9	2.0	-2.4
Std. dev. reaction times	1.3	1.8	2.0	1.4	-1.3
Reaction time trials completed	0.3	0.4	0.5	0.6	-0.7
Reaction time trials AUC	0.1	0.2	0.2	0.4	-0.5
Social response proportion	1.3	1.4	1.6	1.3	-1.1
Social responses	0.3	0.3	0.4	0.5	-0.6
Social time	0.3	0.4	0.4	0.6	-0.7
Conditioned locomotion	1.7	2.0	2.4	1.3	-1.5
Cocaine response after cond. corrected	2.2	2.4	2.7	-1.7	1.5
Cocaine response after cond. not corrected	1.6	1.8	2.0	-1.4	1.3
Cocaine response before conditioning	1.0	1.2	1.5	1.2	-1.0
Saline control response	4.8	6.4	6.9	2.4	-2.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.0	0.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.7	-0.4	0.9
Condit. Reinf. active responses	0.1	0.2	0.3	0.5	-0.2
Condit. Reinf. inactive responses	0.3	0.4	0.5	0.7	-0.6
Condit. Reinf. lever presses	3.0	4.2	5.1	2.3	-1.8
Condit. Reinf. lever reinforcers received	0.4	0.6	0.8	0.9	-0.6
Pavlov. Cond. lever latency	0.7	1.0	1.2	-1.1	0.8
Pavlov. Cond. magazine entry latency	4.5	5.2	5.9	2.4	-2.1
Pavlov. Cond. change in total contacts	2.8	3.9	5.1	2.3	-1.6
Pavlov. Cond. index score	3.3	4.3	5.1	2.3	-1.8
Pavlov. Cond. latency score	2.6	3.3	4.1	2.0	-1.6
Pavlov. Cond. lever contacts	0.7	0.9	1.1	1.1	-0.9
Pavlov. Cond. magazine entry number	8.2	10.1	11.3	-3.4	3.0
Pavlov. Cond. intertrial magazine entries	1.4	1.9	1.9	-1.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	3.9	5.0	5.9	2.4	-2.0
Pavlov. Cond. response bias	2.4	3.4	3.9	2.0	-1.7
Conditioned reinforcement - actives	0.2	0.2	0.3	-0.3	0.6
Conditioned reinforcement - inactives	6.3	7.2	7.8	-2.6	2.8
Conditioned locomotion	9.5	11.3	11.4	-3.4	3.4
Intermittent access intake day 1-15 change	0.6	0.6	0.6	-0.7	0.8
Intermittent access intake escalation	0.5	0.5	0.6	-0.7	0.8
Intermittent access intake escalation 2	0.1	0.1	0.1	-0.3	0.3
Intermitt. access day 1 inactive lever presses	2.4	2.6	2.8	-1.6	1.7
Intermitt. access day 15 inactive lever presses	2.4	2.6	3.2	-1.4	1.8
Intermitt. access escalation Index	4.2	3.8	3.8	-1.9	2.0
Intermittent access day 1 total infusions	5.6	6.4	7.5	-2.3	2.7
Intermittent access day 15 total infusions	8.6	9.6	10.8	-2.9	3.3
Intermittent access terminal intake (last 3 days)	5.7	6.2	7.4	-2.2	2.7
Intermittent access total infusions	4.7	5.3	6.6	-2.0	2.6
Intermittent access day 1 locomotion	4.1	4.2	4.9	-1.9	2.2
Intermittent access day 15 total locomotion	5.2	5.6	6.5	-2.2	2.5
Intermittent access total locomotion	6.2	7.0	8.4	-2.4	2.9
Intermittent access standard deviation	1.4	1.5	1.7	-1.1	1.3
Cocaine induced anxiety	0.0	0.0	0.0	0.0	-0.0
Post-drug Anxiety	1.5	1.7	1.7	1.3	-1.3
Baseline Anxiety	2.9	3.0	3.3	1.7	-1.8
Lifetime Intake	4.1	4.6	5.7	-1.9	2.4
Incentive Sensitization - Responses	0.3	0.3	0.5	-0.4	0.7
Incentive Sensitization - Breakpoint	0.6	0.6	0.8	-0.6	0.9
Progressive ratio test 1 active lever presses	3.5	3.6	4.2	-1.8	2.0
Progressive ratio test 1 breakpoint	3.2	3.3	3.7	-1.7	1.9
Progressive ratio test 1 inactive lever presses	1.5	1.6	1.8	-1.2	1.3
Progressive ratio test 2 active lever presses	4.6	4.9	5.8	-2.0	2.4
Progressive ratio test 2 breakpoint	6.1	6.7	7.6	-2.4	2.7
Progressive ratio test 2 inactive lever presses	9.3	10.7	12.2	-3.0	3.5
Total sessions with >9 infusions	1.9	2.0	2.2	-1.4	1.5
Short access day 1 total inactive lever presses	4.1	4.6	4.7	-2.1	2.2
Short access day 10 total inactive lever presses	4.5	4.9	5.3	-2.3	2.1
Short access day 1 total infusions	3.0	3.2	3.6	-1.7	1.9
Short access day 10 total infusions	1.2	1.3	2.0	-0.8	1.4
Short access total infusions	1.4	1.5	1.9	-1.1	1.4
Short access day 1 locomotion	2.6	2.8	3.2	-1.5	1.8
Short access day 10 total locomotion	1.8	1.9	2.4	-1.2	1.5
Short access total locomotion	1.5	1.5	1.9	-1.1	1.4
Compulsive drug intake	2.3	2.3	2.7	1.3	-1.7
One hour access (0.3 mA shock)	12.0	13.9	15.3	-3.5	3.9
One hour access (shock baseline)	9.6	11.1	12.8	-3.1	3.6
Number of responses in last shaping day	1.8	1.9	1.9	-1.4	1.3
Context. condit. distance diff. score	2.4	2.9	3.1	-1.7	1.6
Locomotion velocity, session 1	0.0	0.0	0.0	-0.2	-0.0
Locomotion distance, session 1	0.4	0.5	0.6	0.8	-0.6
Locomotion velocity, session 2	2.9	3.4	3.7	1.9	-1.8
Locomotion distance, session 2	0.6	0.8	0.9	0.9	-0.9
Locomotion velocity, session 3	0.1	0.2	0.2	-0.3	0.5
Locomotion distance, session 3	0.0	0.1	0.1	-0.2	0.3
Stereotopy head waving bouts, day 3	0.7	0.8	0.9	-0.9	0.8
Stereotopy head waving duration, day 3	0.8	1.0	1.0	-1.0	1.0
Locomotion velocity, session 7	0.4	0.4	0.6	-0.5	0.8
Locomotion distance, session 7	0.1	0.1	0.1	-0.3	0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.0	0.4
Stereotopy head waving duration, day 7	1.3	1.5	2.0	1.4	-1.0
Locomotion velocity, session 8	0.8	0.9	1.1	0.8	-1.1
Locomotion distance, session 8	0.2	0.3	0.3	-0.5	0.5
Degree of sensitization distance	0.0	0.0	0.0	-0.1	0.0
Degree of sensitization stereotypy	0.7	0.8	1.2	1.1	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.2	0.5	-0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.2	-0.1
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	-0.3
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.0	0.1
Incentive salience index mean	0.3	0.4	0.4	0.6	-0.6
Condit. Reinf. lever presses	0.4	0.5	0.5	0.7	-0.7
Time in familiar zone, hab. session 1	0.2	0.2	0.2	-0.4	0.5
Time in novel zone, hab. session 1	0.3	0.3	0.5	-0.7	0.4
Total zone transitions, hab. session 1	0.8	1.1	1.2	1.1	-1.0
Total locomotion distance, hab. session 1	0.3	0.4	0.5	-0.6	0.7
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.1	0.2
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.5	0.0
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.5	-0.2
Total zone transitions, hab. session 2	1.6	2.1	2.5	1.6	-1.3
Total locomotion distance, hab. session 2	0.0	0.0	0.0	0.0	0.1
Locomotion velocity, hab. session 2	0.0	0.1	0.1	-0.1	0.3
Novel to familiar place preference ratio	1.7	1.8	2.3	1.5	-1.2
Novelty place preference	0.8	0.9	1.2	1.1	-0.7
Time in novel zone, NPP test	0.6	0.6	0.8	0.9	-0.6
Total zone transitions, NPP test	2.6	3.7	4.0	2.0	-1.9
Total locomotion distance, NPP test	0.0	0.0	0.0	0.2	-0.2
Locomotion velocity, NPP test	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. lever latency	0.3	0.3	0.4	-0.6	0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	0.6	-0.4
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	0.5	-0.2
Pavlov. Cond. index score	0.2	0.2	0.2	0.5	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	-0.7	0.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	-0.6	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	0.7	-0.6
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	-0.3
Bone: apparent density	0.5	0.8	1.2	1.1	-0.7
Bone surface	5.4	9.4	11.0	3.3	-2.8
Bone volume	2.0	3.4	4.5	2.1	-1.5
Bone: connectivity density	2.7	4.3	5.1	2.3	-1.9
Bone: cortical apparent density	0.3	0.3	0.4	0.5	-0.7
Bone: cortical area	0.7	1.1	1.3	1.2	-1.0
Bone: cortical porosity	0.1	0.1	0.2	0.4	-0.3
Bone: cortical porosity	0.7	0.8	0.8	0.9	-0.9
Bone: cortical thickness	2.5	4.2	4.5	2.0	-2.1
Bone: cortical thickness	0.3	0.4	0.5	0.4	-0.7
Bone: cortical tissue density	0.4	0.5	0.6	0.6	-0.8
Bone: elastic displacement	1.7	1.9	2.3	-1.5	1.2
Bone: elastic work	0.4	0.5	0.7	0.5	-0.9
Bone: endosteal estimation	0.7	1.4	1.8	-1.0	1.3
Bone: endosteal perimeter	0.8	1.6	2.3	-0.9	1.5
Bone: final force	3.5	5.7	5.7	2.4	-2.4
Bone: final moment	3.0	5.0	5.0	2.2	-2.2
Bone: marrow area	0.7	1.6	2.0	-1.1	1.4
Bone: maximum diameter	0.2	0.4	0.6	0.7	-0.5
Bone: maximum force	4.2	7.4	8.2	2.9	-2.6
Bone: maximum moment	3.6	6.2	7.0	2.6	-2.3
Bone: minimum diameter	0.6	1.1	1.5	-0.8	1.2
Bone: periosteal estimation	0.0	0.0	0.0	0.2	0.2
Bone: periosteal perimeter	0.1	0.2	0.4	0.6	-0.3
Bone: post-yield work	1.0	1.4	2.2	1.5	-0.7
Bone: stiffness	3.7	5.8	6.6	2.6	-2.2
Bone: tissue strength	0.1	0.1	0.1	0.4	-0.2
Bone: trabecular number	0.7	1.2	1.7	1.3	-0.8
Bone: trabecular spacing	0.4	0.5	0.7	-0.8	0.5
Bone: trabecular thickness	0.4	0.5	0.7	-0.4	0.8
Bone: trabecular tissue density	4.0	5.7	5.8	-2.4	2.3
Breakpoint value in progressive ratio session	4.2	4.7	5.0	2.2	-2.1
Distance traveled before self-admin	0.7	0.8	1.0	1.0	-0.8
Distance traveled after self-admin	0.4	0.4	0.4	0.7	-0.6
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.3	-0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.5	-0.2
Diff in mean of infusions in LGA sessions	0.5	0.5	0.6	0.7	-0.7
Extinction: sum of active levers before priming	6.1	6.1	6.5	2.5	-2.4
Active lever presses in extinction session 6	2.9	2.8	2.9	1.7	-1.6
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.2	0.0
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	-0.2	-0.1
Time in closed arm before self-admin	0.1	0.1	0.1	0.4	-0.1
Time in closed arm after self-admin	0.0	0.0	0.1	-0.2	0.0
Time in open arm before self-admin	1.0	1.0	1.4	-1.2	0.8
Time in open arm after self-admin	0.3	0.3	0.3	-0.6	0.5
Sum of active levers in priming session hrs 5-6	2.1	2.0	2.2	1.5	-1.4
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.6	0.8	-0.6
Time to tail flick, vehicle, after self-admin	1.1	1.2	1.2	1.1	-1.1
Time to tail flick, test, before self-admin	0.8	0.8	0.9	-0.9	0.9
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.0	-0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.4	0.6	-0.6
Delta time to tail flick, test, before/after SA	1.3	1.1	1.2	1.0	-1.1
Ambulatory time before self-admin	0.7	0.7	1.0	1.0	-0.7
Ambulatory time after self-admin	0.0	0.0	0.0	0.1	0.0
Total heroin consumption	6.8	8.1	8.1	2.8	-2.8
Area under the delay curve	0.1	0.1	0.1	-0.3	0.3
Delay disc. indifference point, 0s delay	0.8	0.8	0.9	-0.9	1.0
Delay disc. indifference point, 16s delay	0.7	0.7	0.8	-0.7	0.9
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.3	0.4
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	-0.5	0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.3	-0.6	0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.3	0.3
Delay discount exponential model param	0.1	0.1	0.1	0.2	-0.3
Delay discount hyperbolic model param	0.0	0.0	0.1	0.2	-0.2
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.5	-0.0
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.2	-0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.6	-0.4	0.8
Bouts of movement, locomotor time 1	1.7	1.9	2.1	1.4	-1.3
Total resting periods, locomotor time 1	1.3	1.5	1.7	1.3	-1.1
Rest time, locomotor task time 1	1.6	1.7	1.8	-1.3	1.3
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.4	-0.3
Vertical activity count, locomotor time 1	1.5	1.6	1.6	-1.2	1.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.3	-0.1
Bouts of movement, locomotor time 2	0.8	0.8	0.9	0.9	-0.9
Total resting periods, locomotor time 2	0.4	0.5	0.5	0.7	-0.7
Rest time, locomotor task time 2	2.9	3.4	3.6	-1.8	1.9
Distance moved, locomotor task time 2	1.2	1.4	1.5	1.2	-1.2
Vertical activity count, locomotor time 2	0.1	0.1	0.1	-0.4	-0.0
Weight adjusted by age	2.7	3.0	3.3	1.8	-1.6
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.0	0.0
Locomotion in novel chamber	5.0	6.1	6.7	-2.4	2.6
Locomotion in novel chamber post-restriction	3.4	4.0	4.2	-1.9	2.0
Progressive ratio	2.6	3.0	3.6	1.9	-1.5
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.3	-0.5
Seeking ratio, punishment vs. effort	2.3	2.9	3.7	-1.9	1.4
Run reversals in cocaine runway, females	0.3	0.3	0.3	0.5	-0.5
Run reversals in cocaine runway, males	0.4	0.4	0.6	-0.8	0.5
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.1	0.2
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	0.2	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.0	-0.0
Cd content in liver	1.2	1.4	1.4	-1.1	1.2
Co content in liver	2.1	2.4	3.2	-1.8	1.3
Cu content in liver	0.3	0.4	0.5	0.7	-0.5
Fe content in liver	0.1	0.1	0.2	0.4	-0.3
K content in liver	1.9	1.9	2.2	1.5	-1.3
Mg content in liver	0.2	0.2	0.3	0.6	-0.2
Mn content in liver	3.3	3.8	4.4	2.1	-1.8
Na content in liver	1.3	1.4	1.4	1.2	-1.2
Rb content in liver	1.5	1.9	2.1	-1.3	1.5
Se content in liver	0.1	0.1	0.2	0.5	0.1
Sr content in liver	3.7	3.4	3.8	1.7	-1.9
Zn content in liver	1.3	1.5	1.6	1.3	-1.2