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Pavlov. Cond. lever latency

Pavlovian Conditioned Approach, Sign-tracking, average lever latency on days 4 and 5 of testing

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

3 loci · 8 genes with independent associations · 171 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	146106284	147631216	3	1	7.47e-08	1.22e-06	1.00e+00	Rab30
2	chr1	149199615	150594931	7	1	1.71e-09	2.46e-09	1.64e-01	Tenm4
3	chr1	150731124	157355948	161	6	2.32e-09	5.61e-09	1.00e+00	Capn5 Emsy LOC120099889 Pak1 Slco2b1 Wnt11

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Tail length	5.69	15	0	0	-1	3.61e-27	Arap1 Art2b Clpb Fchsd2 Folr2 Lamtor1 LOC120097346 LOC120097348 Numa1 P2ry2 P2ry6 Rhog Rnf121 Stim1 Xndc1
Retroperitoneal fat weight	5.55	18	0	0	1	3.96e-49	Acer3 Capn5 Dgat2 Dnajb13 Emsy Fam168a LOC100912071 LOC103691200 LOC120099889 Lrrc32 Mrpl48 Pgm2l1 Tenm4 Thap12 Tsku Ucp2 Uvrag Wnt11
Mean time between licks in bursts	10.59	1	0	0	0	1.00e+00	Uvrag
Condit. Reinf. active minus inactive responses	12.67	5	0	0	-1	4.68e-08	Atg16l2 LOC120097348 Numa1 Plekhb1 Relt
Condit. Reinf. active responses	12.45	51	0	0	-1	1.17e-218	Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099891 LOC120099895 LOC120099897 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rhog Rnf121 Rnf169 Serpinh1 Slco2b1 Stim1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Condit. Reinf. lever presses	21.25	65	55	687.5	-1	0.00e+00	Aamdc Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gab2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Prcp Rab30 Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Condit. Reinf. lever reinforcers received	13.02	56	2	25	-1	5.68e-267	Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. change in total contacts	16.43	65	13	162.5	-1	0.00e+00	Aamdc Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gab2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Prcp Rab30 Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. index score	17.51	65	2	25	-1	0.00e+00	Aamdc Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gab2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Prcp Rab30 Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. latency score	15.86	65	0	0	-1	0.00e+00	Aamdc Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gab2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Prcp Rab30 Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. lever contacts	23.13	65	63	787.5	-1	0.00e+00	Aamdc Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gab2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Prcp Rab30 Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. magazine entry number	14.27	12	0	0	1	1.29e-23	Aamdc Arap1 Capn5 Clpb Gab2 LOC120097348 LOC120099897 Numa1 Nup98 Pde2a Stim1 Tenm4
Pavlov. Cond. lever-magazine prob. diff.	16.41	65	0	0	-1	0.00e+00	Aamdc Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gab2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Prcp Rab30 Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. response bias	23.5	65	61	762.5	-1	0.00e+00	Aamdc Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gab2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Prcp Rab30 Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	10	0.3	1.36
Adipose	alternative TSS	15	0.4	1.43
Adipose	gene expression	13	0.1	1.36
Adipose	isoform ratio	13	0.3	1.4
Adipose	intron excision ratio	3	0.1	1.2
Adipose	mRNA stability	11	0.2	1.39
BLA	alternative polyA	3	0.1	1.36
BLA	alternative TSS	7	0.4	1.39
BLA	gene expression	13	0.2	1.37
BLA	isoform ratio	1	0	1.4
BLA	intron excision ratio	3	0.1	1.32
BLA	mRNA stability	4	0.2	1.36
Brain	alternative polyA	2	0.1	1.32
Brain	alternative TSS	10	0.2	1.34
Brain	gene expression	13	0.1	1.35
Brain	isoform ratio	6	0.1	1.35
Brain	intron excision ratio	9	0.2	1.3
Brain	mRNA stability	9	0.2	1.35
Eye	alternative polyA	0	0	1.32
Eye	alternative TSS	0	0	1.33
Eye	gene expression	3	0.2	1.46
Eye	isoform ratio	0	0	1.22
Eye	intron excision ratio	1	0.1	1.38
Eye	mRNA stability	0	0	1.53
IL	alternative polyA	0	0	1.27
IL	alternative TSS	0	0	1.13
IL	gene expression	5	0.1	1.38
IL	isoform ratio	0	0	1.36
IL	intron excision ratio	1	0.1	1.31
IL	mRNA stability	1	0.1	1.34
LHb	alternative polyA	0	0	1.39
LHb	alternative TSS	0	0	1.34
LHb	gene expression	2	0.1	1.34
LHb	isoform ratio	1	0.1	1.28
LHb	intron excision ratio	0	0	1.25
LHb	mRNA stability	0	0	1.26
Liver	alternative polyA	1	0	1.26
Liver	alternative TSS	3	0.1	1.36
Liver	gene expression	18	0.2	1.39
Liver	isoform ratio	5	0.1	1.35
Liver	intron excision ratio	8	0.2	1.38
Liver	mRNA stability	4	0.1	1.37
NAcc	alternative polyA	2	0.1	1.38
NAcc	alternative TSS	8	0.3	1.32
NAcc	gene expression	11	0.1	1.37
NAcc	isoform ratio	4	0.1	1.36
NAcc	intron excision ratio	4	0.1	1.3
NAcc	mRNA stability	7	0.2	1.37
OFC	alternative polyA	2	0.2	1.42
OFC	alternative TSS	0	0	1.17
OFC	gene expression	2	0	1.32
OFC	isoform ratio	2	0.1	1.41
OFC	intron excision ratio	0	0	1.24
OFC	mRNA stability	1	0.1	1.38
PL	alternative polyA	9	0.3	1.47
PL	alternative TSS	3	0.1	1.34
PL	gene expression	15	0.2	1.36
PL	isoform ratio	4	0.1	1.33
PL	intron excision ratio	6	0.1	1.31
PL	mRNA stability	5	0.1	1.37
pVTA	alternative polyA	0	0	1.47
pVTA	alternative TSS	3	0.2	1.32
pVTA	gene expression	6	0.1	1.38
pVTA	isoform ratio	4	0.2	1.32
pVTA	intron excision ratio	4	0.1	1.3
pVTA	mRNA stability	3	0.2	1.35
RMTg	alternative polyA	0	0	1.18
RMTg	alternative TSS	0	0	1.18
RMTg	gene expression	0	0	1.39
RMTg	isoform ratio	0	0	1.09
RMTg	intron excision ratio	0	0	1.33
RMTg	mRNA stability	0	0	1.41