| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000021117 | 0.0470 | 0.0390 | 1.9e-03 | 0.012 | 0.005 | 0.006 | 0.002 | 1.6e-02 | 7.7e-02 | 6.1e-02 | 1.9e-01 |
| 2 | Adipose | mRNA stability | ENSRNOG00000021117 | 0.0290 | 0.0200 | 3.2e-03 | 0.019 | 0.006 | 0.004 | 0.009 | 2.7e-03 | 6.9e-02 | 1.2e-01 | 3.1e-02 |
| 3 | BLA | gene expression | ENSRNOG00000021117 | 0.3905 | 0.1417 | 6.2e-13 | 0.226 | 0.223 | 0.249 | 0.234 | 2.5e-12 | 3.6e-12 | 1.3e-13 | 9.6e-13 |
| 4 | Brain | gene expression | ENSRNOG00000021117 | 0.0750 | 0.0460 | 1.2e-04 | 0.020 | 0.024 | 0.033 | 0.022 | 4.8e-03 | 2.3e-03 | 4.9e-04 | 3.7e-03 |
| 5 | Brain | mRNA stability | ENSRNOG00000021117 | 0.0361 | 0.0257 | 4.0e-03 | 0.012 | 0.011 | 0.001 | 0.008 | 2.3e-02 | 3.2e-02 | 2.4e-01 | 5.5e-02 |
| 6 | IL | gene expression | ENSRNOG00000021117 | 0.2290 | 0.1450 | 6.5e-03 | 0.088 | 0.065 | 0.155 | 0.124 | 3.9e-03 | 1.2e-02 | 1.5e-04 | 7.0e-04 |
| 7 | Liver | mRNA stability | ENSRNOG00000021117 | 0.0565 | 0.0360 | 2.9e-05 | 0.035 | 0.033 | 0.035 | 0.037 | 8.3e-05 | 1.4e-04 | 8.9e-05 | 4.9e-05 |
| 8 | NAcc | gene expression | ENSRNOG00000021117 | 0.0810 | 0.0490 | 2.0e-05 | 0.037 | 0.061 | 0.048 | 0.056 | 9.5e-04 | 2.5e-05 | 1.9e-04 | 5.2e-05 |
| 9 | OFC | gene expression | ENSRNOG00000021117 | 0.1328 | 0.0860 | 4.5e-03 | 0.090 | 0.075 | 0.085 | 0.108 | 3.8e-03 | 7.8e-03 | 4.8e-03 | 1.6e-03 |
| 10 | PL | gene expression | ENSRNOG00000021117 | 0.1873 | 0.0963 | 4.6e-09 | 0.074 | 0.108 | 0.104 | 0.105 | 2.8e-06 | 1.4e-08 | 2.9e-08 | 2.1e-08 |
| 11 | PL | mRNA stability | ENSRNOG00000021117 | 0.0401 | 0.0276 | 1.2e-03 | 0.044 | 0.037 | 0.034 | 0.035 | 2.7e-04 | 7.5e-04 | 1.3e-03 | 1.0e-03 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| One hour access (0.3 mA shock) | 9.3 | 10.8 | 15.6 | -3.7 | 3.7 | -2.2 | -1.5 | 3.8 | -3.3 | 3.8 | -3.3 | -3.9 | -2.5 | 3.5 |
| Tibialis anterior weight | 9.0 | 31.1 | 43.5 | 6.6 | -6.5 | 3.9 | 1.7 | -6.5 | 5.6 | -6.6 | 5.6 | 6.0 | 3.3 | -6.5 |
| One hour access (shock baseline) | 9.0 | 10.4 | 16.7 | -3.4 | 3.6 | -2.2 | -2.1 | 3.5 | -3.1 | 3.6 | -3.3 | -4.1 | -3.0 | 3.0 |
| Conditioned locomotion | 8.9 | 10.7 | 13.3 | -3.5 | 3.3 | -3.0 | -2.3 | 3.3 | -3.4 | 3.5 | -3.6 | -3.7 | -2.9 | 3.3 |
| Progressive ratio test 2 inactive lever presses | 7.8 | 9.0 | 13.6 | -3.1 | 3.4 | -2.1 | -1.7 | 3.4 | -2.9 | 3.4 | -3.2 | -3.7 | -2.7 | 2.8 |
| Intermittent access day 15 total infusions | 6.9 | 7.7 | 13.2 | -3.2 | 3.3 | -1.4 | -1.1 | 3.3 | -2.6 | 3.3 | -2.7 | -3.6 | -2.2 | 2.5 |
| Extensor digitorum longus weight | 6.8 | 27.2 | 34.6 | 5.7 | -5.8 | 4.5 | 2.9 | -5.8 | 5.4 | -5.9 | 5.6 | 5.4 | 4.0 | -5.6 |
| Conditioned reinforcement - inactives | 6.8 | 7.7 | 9.2 | -2.5 | 2.8 | -2.6 | -2.5 | 2.8 | -2.8 | 2.8 | -3.0 | -3.0 | -2.8 | 2.8 |
| Delay discounting water rate 12 sec | 6.7 | 10.0 | 19.5 | -3.2 | 3.8 | -2.4 | -1.2 | 3.7 | -4.4 | 3.6 | -3.3 | -2.9 | -1.7 | 3.3 |
| Progressive ratio test 2 breakpoint | 6.3 | 7.0 | 9.9 | -2.8 | 2.8 | -2.2 | -1.6 | 2.8 | -2.5 | 2.8 | -2.8 | -3.1 | -2.4 | 3.0 |
| Indifference point function ln k | 5.7 | 8.1 | 13.7 | -3.6 | 3.7 | -0.8 | 0.6 | 3.7 | -3.1 | 3.6 | -2.4 | -2.9 | -0.5 | 3.2 |
| Indifference point function log k | 5.7 | 8.1 | 13.7 | -3.6 | 3.7 | -0.8 | 0.6 | 3.7 | -3.1 | 3.6 | -2.4 | -2.9 | -0.5 | 3.2 |
| Pavlov. Cond. magazine entry number | 5.0 | 6.2 | 10.8 | -3.0 | 3.0 | -1.4 | -0.2 | 3.0 | -2.8 | 3.0 | -2.3 | -2.4 | -0.9 | 3.3 |
| Progressive ratio test 2 active lever presses | 4.7 | 5.0 | 7.7 | -2.4 | 2.5 | -1.6 | -1.2 | 2.4 | -2.0 | 2.5 | -2.3 | -2.8 | -2.0 | 2.5 |
| BMI with tail | 4.4 | 14.3 | 31.2 | 3.2 | -2.7 | 5.6 | 4.6 | -2.7 | 4.1 | -2.7 | 4.6 | 3.0 | 4.2 | -2.9 |
| Intermittent access total locomotion | 4.4 | 5.0 | 9.5 | -2.7 | 2.9 | -0.3 | -0.2 | 2.9 | -1.7 | 2.9 | -1.9 | -3.1 | -1.2 | 2.3 |
| Body weight | 4.3 | 18.2 | 22.8 | 4.4 | -4.1 | 4.7 | 3.5 | -4.0 | 4.7 | -4.1 | 4.8 | 4.1 | 3.9 | -4.4 |
| Total heroin consumption | 4.3 | 5.1 | 7.8 | 2.8 | -2.7 | 1.5 | 0.5 | -2.8 | 2.0 | -2.8 | 2.2 | 2.5 | 1.1 | -2.7 |
| Locomotion in novel chamber | 4.3 | 5.3 | 8.2 | -2.5 | 2.6 | -1.6 | -1.3 | 2.7 | -1.8 | 2.5 | -2.4 | -2.9 | -2.2 | 2.4 |
| Intermittent access terminal intake (last 3 days) | 4.2 | 4.6 | 8.9 | -2.5 | 2.7 | -0.6 | -0.7 | 2.7 | -1.8 | 2.7 | -2.0 | -3.0 | -1.6 | 1.8 |
| Intermittent access day 15 total locomotion | 4.0 | 4.3 | 7.2 | -2.2 | 2.5 | -1.1 | -1.0 | 2.5 | -1.7 | 2.5 | -2.1 | -2.7 | -1.7 | 1.9 |
| Short access day 1 total inactive lever presses | 4.0 | 4.4 | 7.0 | -2.6 | 2.5 | -0.8 | -0.3 | 2.4 | -2.3 | 2.4 | -2.0 | -2.5 | -1.0 | 2.6 |
| Bone surface | 4.0 | 7.1 | 14.7 | 2.9 | -2.8 | 2.6 | 1.1 | -2.8 | 3.8 | -2.8 | 2.8 | 2.1 | 1.5 | -2.9 |
| Extinction: sum of active levers before priming | 4.0 | 4.0 | 5.5 | 2.3 | -2.3 | 1.8 | 0.6 | -2.3 | 2.3 | -2.2 | 2.0 | 2.1 | 1.2 | -2.1 |
| Retroperitoneal fat weight | 3.9 | 12.9 | 21.4 | -4.3 | 4.6 | -1.3 | -0.3 | 4.6 | -3.1 | 4.6 | -3.4 | -4.5 | -1.9 | 3.8 |
| Delay discounting water rate 0 sec | 3.9 | 6.2 | 9.3 | -2.3 | 2.8 | -2.3 | -1.8 | 2.7 | -3.0 | 2.7 | -2.9 | -2.3 | -2.2 | 2.2 |
| Intermittent access day 1 total infusions | 3.9 | 4.4 | 8.4 | -2.7 | 2.7 | -0.1 | 0.5 | 2.6 | -1.8 | 2.7 | -1.5 | -2.9 | -0.6 | 2.3 |
| Delay discounting total patch changes 12 sec | 3.7 | 4.9 | 9.0 | 2.5 | -2.7 | 1.6 | 0.3 | -2.7 | 2.2 | -2.5 | 2.1 | 2.2 | 1.0 | -3.0 |
| Intermittent access total infusions | 3.7 | 4.1 | 8.2 | -2.5 | 2.5 | -0.5 | -0.2 | 2.5 | -1.7 | 2.5 | -1.8 | -2.9 | -1.3 | 2.1 |
| Saline control response | 3.6 | 4.8 | 6.7 | 2.5 | -2.4 | 1.5 | 1.1 | -2.4 | 2.3 | -2.4 | 2.3 | 2.6 | 1.7 | -2.4 |
| Time to tail flick, vehicle, after self-admin | 3.6 | 3.8 | 6.3 | 1.8 | -1.3 | 2.4 | 2.3 | -1.3 | 1.9 | -1.3 | 2.5 | 2.0 | 2.5 | -1.5 |
| Bone: maximum force | 3.4 | 5.9 | 10.8 | 2.4 | -2.4 | 2.8 | 2.0 | -2.3 | 3.3 | -2.5 | 2.7 | 1.8 | 1.8 | -2.3 |
| Soleus weight | 3.2 | 9.5 | 13.8 | -3.7 | 3.7 | -1.8 | -0.5 | 3.7 | -3.0 | 3.7 | -3.1 | -3.4 | -1.7 | 3.7 |
| Delay discounting water rate 6 sec | 3.2 | 4.7 | 8.7 | -2.3 | 2.8 | -1.3 | -0.3 | 2.7 | -3.0 | 2.6 | -2.1 | -1.8 | -0.8 | 2.5 |
| Reaction time premature initiations | 3.2 | 4.6 | 8.4 | 2.3 | -2.5 | 1.6 | 1.2 | -2.3 | 1.5 | -2.6 | 2.2 | 2.9 | 2.0 | -1.8 |
| Pavlov. Cond. magazine entry latency | 3.2 | 3.7 | 6.5 | 2.4 | -2.2 | 1.3 | 0.5 | -2.2 | 2.1 | -2.1 | 1.8 | 1.9 | 0.9 | -2.6 |
| Progressive ratio test 1 active lever presses | 3.2 | 3.3 | 4.7 | -2.0 | 2.0 | -1.4 | -0.9 | 1.9 | -1.9 | 2.0 | -1.9 | -2.2 | -1.4 | 2.2 |
| Bone: trabecular tissue density | 3.2 | 4.4 | 5.6 | -2.3 | 2.3 | -2.1 | -1.3 | 2.3 | -1.8 | 2.4 | -2.4 | -2.3 | -1.9 | 2.1 |
| Intermitt. access day 15 inactive lever presses | 3.1 | 3.4 | 5.6 | -2.0 | 1.9 | -1.3 | -1.5 | 1.9 | -1.6 | 1.8 | -2.0 | -2.4 | -1.9 | 1.9 |
| Lifetime Intake | 3.1 | 3.5 | 6.8 | -2.4 | 2.4 | -0.1 | 0.2 | 2.3 | -1.6 | 2.3 | -1.5 | -2.6 | -0.8 | 2.0 |
| Short access day 10 total inactive lever presses | 3.1 | 3.4 | 5.8 | -2.2 | 2.2 | -1.2 | -0.2 | 2.2 | -2.4 | 2.1 | -1.8 | -1.9 | -0.7 | 2.1 |
| Delay discounting water rate 24 sec | 3.0 | 4.1 | 7.9 | -1.9 | 2.6 | -1.3 | -0.6 | 2.5 | -2.8 | 2.5 | -2.0 | -1.8 | -1.0 | 2.0 |
| Progressive ratio test 1 breakpoint | 2.9 | 2.9 | 4.1 | -1.8 | 1.9 | -1.4 | -1.0 | 1.8 | -1.7 | 1.9 | -1.8 | -2.0 | -1.4 | 2.0 |
| Bone: maximum moment | 2.9 | 5.1 | 9.0 | 2.2 | -2.2 | 2.6 | 1.9 | -2.1 | 3.0 | -2.3 | 2.5 | 1.7 | 1.7 | -2.2 |
| BMI without tail | 2.8 | 5.9 | 10.2 | 2.3 | -1.5 | 3.2 | 3.0 | -1.7 | 2.6 | -1.7 | 2.9 | 2.3 | 2.9 | -1.9 |
| Bone: final force | 2.8 | 4.6 | 6.6 | 2.3 | -2.3 | 2.1 | 1.3 | -2.2 | 2.6 | -2.4 | 2.3 | 2.0 | 1.5 | -2.2 |
| Progressive ratio | 2.8 | 3.3 | 7.1 | 1.6 | -1.8 | 2.0 | 1.2 | -1.8 | 2.7 | -1.8 | 2.0 | 1.5 | 1.5 | -1.8 |
| Locomotion velocity, session 2 | 2.7 | 3.2 | 4.0 | 1.7 | -1.9 | 1.9 | 1.2 | -1.9 | 1.8 | -1.9 | 2.0 | 1.8 | 1.6 | -1.6 |
| Locomotion in novel chamber post-restriction | 2.7 | 3.2 | 4.5 | -2.1 | 2.1 | -1.5 | -0.7 | 2.0 | -1.6 | 2.1 | -1.9 | -2.0 | -1.4 | 1.9 |
| Indifference point AUC | 2.6 | 3.0 | 5.3 | 2.3 | -2.2 | 0.5 | -0.2 | -2.2 | 2.0 | -2.1 | 1.6 | 1.8 | 0.4 | -2.0 |
| Reaction time mean minus median | 2.6 | 3.4 | 7.4 | 2.4 | -2.2 | 0.8 | 0.1 | -2.0 | 2.7 | -2.3 | 1.6 | 1.5 | 0.4 | -2.1 |
| Intermittent access day 1 locomotion | 2.6 | 2.7 | 4.9 | -2.1 | 2.2 | 0.6 | 1.3 | 2.1 | -1.4 | 2.2 | -0.8 | -2.0 | 0.3 | 1.5 |
| Bone: connectivity density | 2.6 | 4.1 | 7.4 | 2.0 | -1.9 | 2.4 | 1.4 | -2.0 | 2.7 | -1.9 | 2.2 | 1.7 | 1.7 | -2.1 |
| Heart weight | 2.5 | 3.6 | 6.3 | -2.3 | 2.4 | -0.5 | 0.2 | 2.5 | -2.1 | 2.5 | -1.6 | -2.1 | -0.4 | 1.9 |
| Reaction time premature initiation rate | 2.5 | 3.4 | 5.7 | 1.7 | -1.9 | 1.6 | 1.6 | -1.8 | 1.3 | -2.0 | 2.1 | 2.4 | 2.2 | -1.2 |
| Pavlov. Cond. lever-magazine prob. diff. | 2.5 | 3.2 | 5.7 | 2.2 | -2.1 | 1.2 | 0.1 | -2.1 | 2.4 | -2.1 | 1.6 | 1.5 | 0.5 | -2.4 |
| Bone: stiffness | 2.5 | 3.9 | 8.0 | 2.1 | -2.2 | 1.9 | 1.2 | -2.1 | 2.8 | -2.2 | 2.1 | 1.5 | 1.1 | -2.0 |
| K content in liver | 2.5 | 2.5 | 4.2 | 1.4 | -1.2 | 2.0 | 1.9 | -1.2 | 2.1 | -1.2 | 1.9 | 1.4 | 1.8 | -1.1 |
| Intermitt. access day 1 inactive lever presses | 2.4 | 2.6 | 3.8 | -1.7 | 1.7 | -1.2 | -0.8 | 1.7 | -1.7 | 1.7 | -1.6 | -1.9 | -1.3 | 2.0 |
| Bone: final moment | 2.4 | 4.0 | 5.6 | 2.2 | -2.1 | 1.9 | 1.2 | -2.1 | 2.4 | -2.2 | 2.2 | 1.9 | 1.4 | -2.1 |
| Sr content in liver | 2.4 | 2.2 | 4.0 | 1.8 | -2.0 | -0.0 | -0.9 | -2.0 | 1.0 | -1.9 | 1.0 | 1.6 | 0.1 | -2.0 |
| Delay discounting water rate 18 sec | 2.3 | 3.0 | 5.8 | -1.9 | 2.3 | -0.9 | 0.3 | 2.2 | -2.4 | 2.1 | -1.6 | -1.6 | -0.3 | 1.9 |
| Short access day 1 total infusions | 2.3 | 2.4 | 4.3 | -2.0 | 2.0 | 0.0 | 0.6 | 1.8 | -1.5 | 1.9 | -1.1 | -2.0 | -0.2 | 2.1 |
| Total zone transitions, NPP test | 2.3 | 3.3 | 4.4 | 1.8 | -2.0 | 1.9 | 1.2 | -1.9 | 2.1 | -2.0 | 2.0 | 1.6 | 1.5 | -1.8 |
| Intraocular pressure | 2.1 | 2.9 | 7.1 | -0.7 | 1.4 | -1.9 | -2.6 | 1.2 | -1.5 | 1.0 | -2.1 | -1.3 | -2.7 | 0.9 |
| Pavlov. Cond. index score | 2.1 | 2.7 | 5.3 | 2.0 | -1.9 | 1.1 | 0.1 | -1.9 | 2.3 | -1.9 | 1.4 | 1.2 | 0.3 | -2.2 |
| Compulsive drug intake | 2.1 | 2.1 | 4.4 | 1.5 | -1.8 | 0.6 | 0.6 | -1.7 | 1.0 | -1.8 | 1.3 | 2.1 | 1.3 | -1.1 |
| Breakpoint value in progressive ratio session | 2.1 | 2.3 | 3.7 | 1.9 | -1.9 | 0.7 | -0.2 | -1.9 | 1.8 | -1.9 | 1.4 | 1.5 | 0.4 | -1.6 |
| Delay discounting total patch changes 24 sec | 2.0 | 2.5 | 4.9 | 2.0 | -2.0 | 0.9 | 0.1 | -1.9 | 1.1 | -1.9 | 1.4 | 1.7 | 0.6 | -2.2 |
| Baseline Anxiety | 2.0 | 2.2 | 3.8 | 1.5 | -1.6 | 1.3 | 0.5 | -1.6 | 1.6 | -1.6 | 1.4 | 1.6 | 1.0 | -2.0 |
| Seeking ratio, punishment vs. effort | 2.0 | 2.4 | 7.3 | -1.5 | 1.7 | -1.4 | -0.4 | 1.7 | -2.7 | 1.8 | -1.5 | -1.0 | -0.6 | 1.7 |
| Run reversals in cocaine runway, females | 2.0 | 1.9 | 6.5 | 0.4 | -0.6 | 2.0 | 2.5 | -0.6 | 1.0 | -0.6 | 1.6 | 0.9 | 2.3 | -0.6 |
| Intermitt. access escalation Index | 1.9 | 1.7 | 3.1 | -1.6 | 1.8 | -0.5 | 0.3 | 1.8 | -1.5 | 1.8 | -1.0 | -1.2 | -0.1 | 1.4 |
| Active lever presses in extinction session 6 | 1.9 | 1.8 | 3.3 | 1.6 | -1.7 | 0.3 | -0.8 | -1.7 | 1.5 | -1.7 | 0.9 | 1.2 | -0.2 | -1.8 |
| Rest time, locomotor task time 2 | 1.9 | 2.2 | 3.9 | -2.0 | 1.8 | -0.6 | 0.1 | 1.8 | -1.3 | 1.8 | -1.4 | -1.8 | -0.7 | 1.7 |
| Length with tail | 1.8 | 6.5 | 10.0 | 3.0 | -3.0 | 1.5 | 0.7 | -2.9 | 2.6 | -3.0 | 2.5 | 2.8 | 1.6 | -3.2 |
| Locomotor testing distance | 1.8 | 2.9 | 5.4 | -2.0 | 2.3 | -0.8 | 0.2 | 2.1 | -2.3 | 2.3 | -1.5 | -1.2 | -0.1 | 1.8 |
| Pavlov. Cond. latency score | 1.8 | 2.2 | 4.8 | 1.8 | -1.6 | 1.2 | 0.2 | -1.6 | 2.2 | -1.6 | 1.3 | 1.1 | 0.4 | -2.0 |
| Total zone transitions, hab. session 2 | 1.8 | 2.3 | 4.3 | 1.1 | -1.4 | 2.1 | 1.7 | -1.2 | 1.7 | -1.4 | 1.8 | 1.2 | 1.7 | -1.1 |
| Bone: cortical thickness | 1.8 | 3.0 | 5.4 | 2.2 | -2.0 | 0.3 | -0.0 | -2.1 | 1.3 | -2.2 | 1.5 | 2.3 | 0.8 | -2.3 |
| Rest time, locomotor task time 1 | 1.8 | 1.9 | 2.7 | -1.3 | 1.4 | -1.6 | -1.1 | 1.3 | -1.2 | 1.3 | -1.6 | -1.3 | -1.4 | 1.6 |
| Delay discounting time to switch 0 sec | 1.7 | 2.6 | 5.5 | 1.3 | -1.7 | 1.7 | 1.3 | -1.7 | 2.3 | -1.6 | 1.9 | 1.2 | 1.3 | -1.2 |
| Condit. Reinf. lever presses | 1.7 | 2.3 | 7.2 | 1.7 | -1.6 | 0.9 | 0.0 | -1.7 | 2.7 | -1.7 | 1.3 | 1.0 | 0.3 | -1.8 |
| Weight adjusted by age | 1.7 | 2.0 | 3.3 | 1.8 | -1.8 | 0.8 | 0.2 | -1.5 | 1.5 | -1.7 | 1.3 | 1.6 | 0.5 | -1.5 |
| Co content in liver | 1.7 | 2.0 | 7.2 | -1.1 | 1.2 | -1.8 | -1.1 | 1.2 | -2.7 | 1.3 | -1.5 | -0.5 | -0.8 | 1.3 |
| Epididymis fat weight | 1.6 | 3.8 | 7.3 | -2.3 | 2.6 | 0.2 | -0.0 | 2.7 | -1.6 | 2.7 | -1.7 | -2.5 | -0.9 | 1.6 |
| Length without tail | 1.6 | 3.5 | 5.3 | 1.9 | -2.3 | 1.8 | 0.8 | -2.0 | 2.0 | -2.2 | 1.8 | 1.6 | 1.2 | -2.3 |
| Short access day 1 locomotion | 1.6 | 1.7 | 3.0 | -1.6 | 1.7 | 0.7 | 1.0 | 1.7 | -1.2 | 1.7 | -0.7 | -1.7 | 0.2 | 0.8 |
| Mn content in liver | 1.6 | 1.8 | 3.2 | 1.7 | -1.6 | 0.8 | -0.1 | -1.7 | 1.5 | -1.8 | 1.1 | 1.1 | 0.1 | -1.8 |
| Locomotor testing rearing | 1.5 | 2.3 | 5.2 | -1.8 | 2.0 | -0.6 | 0.2 | 1.9 | -2.3 | 2.0 | -1.2 | -1.2 | -0.1 | 1.5 |
| Total sessions with >9 infusions | 1.5 | 1.6 | 2.7 | -1.6 | 1.6 | 0.5 | 1.0 | 1.6 | -1.1 | 1.6 | -0.6 | -1.6 | 0.3 | 1.4 |
| Bone volume | 1.5 | 2.5 | 7.3 | 1.6 | -1.6 | 1.8 | 0.7 | -1.6 | 2.7 | -1.5 | 1.6 | 0.9 | 0.7 | -1.8 |
| Glucose | 1.4 | 2.2 | 3.9 | -1.9 | 2.0 | 0.4 | 0.7 | 2.0 | -0.8 | 1.8 | -0.9 | -1.9 | -0.2 | 1.9 |
| Reaction time mean minus median AUC | 1.4 | 1.8 | 3.6 | 1.9 | -1.5 | 0.4 | -0.2 | -1.4 | 1.8 | -1.7 | 1.0 | 1.2 | 0.1 | -1.7 |
| Pavlov. Cond. response bias | 1.4 | 2.0 | 3.9 | 1.7 | -1.6 | 0.7 | -0.2 | -1.6 | 2.0 | -1.7 | 1.1 | 1.1 | 0.1 | -2.0 |
| Intermittent access standard deviation | 1.4 | 1.5 | 2.3 | -1.2 | 1.2 | -1.0 | -1.3 | 1.2 | -1.1 | 1.2 | -1.5 | -1.4 | -1.5 | 0.2 |
| Sum of active levers in priming session hrs 5-6 | 1.4 | 1.4 | 3.7 | 1.2 | -1.2 | -0.8 | -1.9 | -1.2 | 0.8 | -1.2 | -0.1 | 0.4 | -1.5 | -1.2 |
| Delta time to tail flick, test, before/after SA | 1.4 | 1.3 | 3.1 | 1.2 | -1.2 | -1.4 | -1.8 | -1.2 | 0.8 | -1.2 | 0.1 | 1.0 | -0.8 | -0.9 |
| Bouts of movement, locomotor time 1 | 1.4 | 1.5 | 5.1 | 1.1 | -1.1 | -1.6 | -2.3 | -1.3 | 0.2 | -1.2 | -0.3 | 0.8 | -1.3 | -1.1 |
| Locomotor activity | 1.3 | 2.0 | 3.7 | -1.6 | 1.9 | -0.9 | -0.2 | 1.8 | -1.7 | 1.9 | -1.5 | -1.2 | -0.4 | 1.4 |
| Light reinforcement 2 | 1.3 | 1.8 | 4.1 | -1.5 | 0.9 | -1.1 | -1.2 | 0.9 | -0.6 | 1.0 | -1.6 | -2.0 | -1.8 | 1.2 |
| Conditioned locomotion | 1.3 | 1.6 | 2.3 | 1.5 | -1.4 | 1.2 | 0.7 | -1.3 | 1.0 | -1.5 | 1.4 | 1.4 | 1.1 | -1.2 |
| Pavlov. Cond. change in total contacts | 1.3 | 1.8 | 4.2 | 1.6 | -1.6 | 0.5 | -0.7 | -1.6 | 2.1 | -1.7 | 0.8 | 0.7 | -0.5 | -1.8 |
| Intermittent access intake day 1-15 change | 1.3 | 1.3 | 3.0 | -0.7 | 0.9 | -1.3 | -1.7 | 0.9 | -0.8 | 0.9 | -1.3 | -1.0 | -1.7 | 0.4 |
| Short access day 10 total infusions | 1.3 | 1.5 | 2.8 | -1.7 | 1.4 | 0.9 | 1.3 | 1.4 | -0.4 | 1.4 | -0.4 | -1.6 | 0.3 | 1.4 |
| Pavlov. Cond. intertrial magazine entries | 1.3 | 1.6 | 3.0 | -0.9 | 0.9 | -1.6 | -1.6 | 0.9 | -1.4 | 1.0 | -1.6 | -1.0 | -1.7 | 0.8 |
| Cd content in liver | 1.3 | 1.4 | 2.1 | -0.6 | 1.1 | -1.3 | -1.3 | 1.0 | -1.4 | 1.2 | -1.3 | -1.1 | -1.4 | 1.1 |
| Parametrial fat weight | 1.2 | 2.4 | 5.0 | -1.8 | 2.1 | 0.6 | 0.8 | 2.2 | -1.0 | 2.2 | -0.8 | -2.1 | -0.1 | 1.3 |
| Short access total infusions | 1.2 | 1.3 | 2.3 | -1.5 | 1.4 | 0.7 | 1.2 | 1.3 | -0.7 | 1.3 | -0.4 | -1.5 | 0.4 | 1.4 |
| Context. condit. distance diff. score | 1.2 | 1.4 | 2.8 | -1.5 | 1.6 | -0.3 | 0.4 | 1.6 | -1.2 | 1.7 | -0.9 | -1.2 | -0.1 | 1.2 |
| Bone: elastic displacement | 1.2 | 1.3 | 4.1 | -1.3 | 1.3 | -0.9 | -0.3 | 1.2 | -2.0 | 1.2 | -1.1 | -0.7 | -0.4 | 1.3 |
| Time to tail flick, vehicle, before self-admin | 1.2 | 1.3 | 2.4 | 1.1 | -0.9 | 1.6 | 1.2 | -0.8 | 1.5 | -0.7 | 1.4 | 0.7 | 1.2 | -0.8 |
| Total resting periods, locomotor time 1 | 1.2 | 1.3 | 4.8 | 0.9 | -0.9 | -1.5 | -2.2 | -1.1 | 0.3 | -1.0 | -0.4 | 0.6 | -1.4 | -1.0 |
| Short access day 10 total locomotion | 1.1 | 1.2 | 2.4 | -1.4 | 1.5 | 0.2 | 0.5 | 1.5 | -0.9 | 1.5 | -0.7 | -1.4 | -0.1 | 0.8 |
| Number of responses in last shaping day | 1.1 | 1.2 | 3.1 | -1.1 | 1.3 | -0.4 | -0.2 | 1.2 | -1.8 | 1.3 | -1.1 | -1.1 | -0.5 | 0.8 |
| Locomotion distance, session 1 | 1.1 | 1.5 | 3.6 | 0.4 | -0.7 | 1.9 | 1.9 | -0.7 | 1.1 | -0.8 | 1.4 | 0.8 | 1.8 | -0.5 |
| Locomotion velocity, session 8 | 1.1 | 1.3 | 2.6 | 0.9 | -1.1 | 1.2 | 1.1 | -1.0 | 0.8 | -1.1 | 1.5 | 1.3 | 1.6 | -0.9 |
| Bone: post-yield work | 1.1 | 1.4 | 7.6 | 0.4 | -0.6 | 1.8 | 1.5 | -0.3 | 2.8 | -0.6 | 1.1 | -0.5 | 0.7 | -0.2 |
| Rb content in liver | 1.1 | 1.4 | 2.7 | -1.4 | 1.6 | -0.2 | 0.7 | 1.6 | -0.8 | 1.5 | -0.8 | -1.3 | -0.1 | 1.5 |
| Cocaine response after cond. corrected | 1.0 | 1.2 | 2.5 | -1.1 | 1.4 | 0.3 | 0.9 | 1.6 | -1.3 | 1.3 | -0.5 | -0.9 | 0.5 | 1.3 |
| Intermittent access intake escalation | 1.0 | 1.0 | 2.3 | -0.7 | 0.8 | -1.0 | -1.4 | 0.8 | -0.7 | 0.8 | -1.2 | -1.0 | -1.5 | 0.3 |
| Incentive Sensitization - Breakpoint | 1.0 | 1.0 | 1.8 | -0.9 | 1.1 | -0.8 | -0.8 | 1.0 | -0.7 | 1.0 | -1.1 | -1.3 | -1.2 | 1.1 |
| Short access total locomotion | 1.0 | 1.0 | 1.9 | -1.3 | 1.3 | 0.5 | 0.9 | 1.3 | -0.9 | 1.4 | -0.4 | -1.3 | 0.3 | 0.8 |
| Stereotopy head waving bouts, day 3 | 1.0 | 1.2 | 4.5 | -1.0 | 0.8 | 1.3 | 2.1 | 1.0 | 0.4 | 0.8 | 0.3 | -0.7 | 1.3 | 1.1 |
| Novel to familiar place preference ratio | 1.0 | 1.0 | 2.0 | 1.3 | -1.2 | 0.3 | -0.6 | -1.1 | 1.4 | -1.2 | 0.7 | 0.6 | -0.3 | -1.4 |
| Progressive ratio test 1 inactive lever presses | 0.9 | 1.0 | 1.6 | -1.1 | 1.3 | -0.3 | -0.2 | 1.2 | -1.3 | 1.3 | -1.0 | -1.2 | -0.5 | 0.7 |
| Locomotion distance, session 2 | 0.9 | 1.3 | 2.7 | 0.7 | -0.9 | 1.6 | 1.4 | -0.9 | 0.8 | -1.0 | 1.4 | 1.0 | 1.6 | -0.5 |
| Locomotion velocity, session 3 | 0.9 | 1.1 | 4.3 | -0.8 | 0.5 | 1.6 | 2.1 | 0.7 | 0.3 | 0.4 | 0.6 | -0.5 | 1.4 | 0.7 |
| Stereotopy head waving duration, day 7 | 0.9 | 1.1 | 2.3 | 1.1 | -1.2 | 0.8 | -0.1 | -1.3 | 1.5 | -1.1 | 0.9 | 0.7 | 0.2 | -1.5 |
| Time to tail flick, test, before self-admin | 0.9 | 0.9 | 3.1 | -0.8 | 0.9 | 1.5 | 1.8 | 0.8 | -0.6 | 0.8 | 0.2 | -0.7 | 1.0 | 0.4 |
| Delta time to tail flick, vehicle, before/after SA | 0.9 | 0.9 | 1.6 | 0.8 | -0.5 | 1.1 | 1.1 | -0.6 | 0.8 | -0.7 | 1.2 | 1.2 | 1.3 | -0.6 |
| Delay disc. indifference point, 16s delay | 0.9 | 0.9 | 1.2 | -1.0 | 1.0 | -0.7 | -0.4 | 1.1 | -1.1 | 1.1 | -0.9 | -1.1 | -0.7 | 1.0 |
| Distance moved, locomotor task time 2 | 0.9 | 1.1 | 2.3 | 1.3 | -1.3 | 0.6 | -0.2 | -1.1 | 0.8 | -1.3 | 0.8 | 1.2 | 0.2 | -1.5 |
| Na content in liver | 0.9 | 1.0 | 1.9 | 1.0 | -1.2 | 0.6 | 0.3 | -1.2 | 1.4 | -1.3 | 0.9 | 0.8 | 0.4 | -1.0 |
| Zn content in liver | 0.9 | 1.0 | 2.0 | 1.1 | -1.4 | 0.4 | -0.2 | -1.3 | 0.7 | -1.2 | 0.9 | 0.9 | 0.3 | -1.4 |
| Tibia length | 0.8 | 2.2 | 4.5 | 1.9 | -1.8 | 0.2 | -1.1 | -1.9 | 2.1 | -1.8 | 0.8 | 0.9 | -0.7 | -1.7 |
| Delay discounting total patch changes 6 sec | 0.8 | 1.2 | 1.6 | 1.0 | -1.1 | 1.1 | 0.9 | -1.1 | 0.9 | -1.1 | 1.3 | 1.1 | 1.1 | -1.1 |
| Social response proportion | 0.8 | 0.8 | 2.1 | 1.0 | -1.2 | 0.2 | -0.2 | -0.9 | 1.4 | -1.1 | 0.9 | 0.9 | 0.4 | -0.8 |
| Cocaine response after cond. not corrected | 0.8 | 0.8 | 1.9 | -0.9 | 1.3 | 0.5 | 1.0 | 1.4 | -0.8 | 1.2 | -0.3 | -0.6 | 0.5 | 0.9 |
| Pavlov. Cond. intertrial magazine entries | 0.8 | 1.1 | 1.8 | -1.1 | 1.3 | -0.7 | -0.4 | 1.2 | -0.9 | 1.3 | -1.1 | -1.1 | -0.7 | 1.3 |
| Intermittent access intake escalation 2 | 0.8 | 0.8 | 2.6 | -0.3 | 0.4 | -1.1 | -1.6 | 0.4 | -0.6 | 0.4 | -1.0 | -0.7 | -1.6 | 0.0 |
| Post-drug Anxiety | 0.8 | 0.9 | 1.5 | 1.1 | -1.2 | 0.6 | -0.3 | -1.2 | 1.1 | -1.2 | 0.8 | 0.8 | 0.0 | -1.0 |
| Bone: apparent density | 0.8 | 1.3 | 3.2 | 0.8 | -0.7 | 1.8 | 1.2 | -0.8 | 1.8 | -0.7 | 1.3 | 0.6 | 1.1 | -0.9 |
| Change in fecal boli incidents, locomotor task | 0.8 | 0.7 | 3.3 | -0.3 | 0.2 | 1.0 | 1.8 | 0.1 | -0.6 | 0.0 | 0.6 | 0.3 | 1.5 | 0.7 |
| Vertical activity count, locomotor time 1 | 0.8 | 0.8 | 1.7 | -1.2 | 1.2 | 0.1 | 0.1 | 1.3 | -0.7 | 1.3 | -0.7 | -1.1 | -0.2 | 0.7 |
| Tail length | 0.7 | 2.1 | 4.1 | 1.9 | -1.5 | 0.0 | -0.0 | -1.8 | 1.3 | -1.6 | 1.2 | 2.0 | 0.8 | -1.9 |
| Reaction time omissions | 0.7 | 1.0 | 2.4 | 1.1 | -1.2 | 0.5 | -0.1 | -1.0 | 1.0 | -1.4 | 0.7 | 0.7 | 0.2 | -1.6 |
| Conditioned reinforcement - actives | 0.7 | 0.6 | 1.5 | -0.7 | 0.4 | -1.0 | -1.1 | 0.4 | -0.3 | 0.5 | -0.9 | -1.0 | -1.2 | 0.6 |
| Incentive Sensitization - Responses | 0.7 | 0.7 | 1.3 | -0.7 | 0.9 | -0.6 | -0.6 | 0.8 | -0.5 | 0.8 | -0.9 | -1.1 | -1.0 | 0.9 |
| Bone: endosteal perimeter | 0.7 | 1.5 | 4.0 | -1.4 | 1.4 | 0.8 | 0.9 | 1.4 | 0.4 | 1.5 | -0.4 | -2.0 | -0.2 | 1.5 |
| Bone: marrow area | 0.7 | 1.5 | 2.8 | -1.3 | 1.3 | 1.3 | 1.7 | 1.3 | 0.3 | 1.4 | -0.1 | -1.5 | 0.6 | 1.5 |
| Delay disc. indifference point, 0s delay | 0.7 | 0.8 | 2.6 | -0.4 | 0.4 | 1.3 | 1.6 | 0.4 | 0.2 | 0.4 | 0.8 | 0.1 | 1.6 | 0.4 |
| Distance moved, locomotor task time 1 | 0.7 | 0.8 | 3.1 | 0.5 | -0.4 | 1.8 | 1.2 | -0.2 | 0.8 | -0.3 | 0.9 | 0.5 | 1.0 | -1.0 |
| Mean time between licks in bursts | 0.6 | 0.8 | 2.0 | 0.6 | -0.5 | 0.9 | 1.1 | -0.5 | 0.1 | -0.7 | 1.0 | 1.3 | 1.4 | -0.7 |
| Water consumed over 24 hours | 0.6 | 0.7 | 1.3 | 1.1 | -1.0 | -0.3 | -0.6 | -1.0 | 0.1 | -1.1 | 0.4 | 1.1 | 0.0 | -0.9 |
| Std. dev. reaction times | 0.6 | 0.8 | 1.7 | 1.1 | -1.1 | -0.2 | -0.6 | -0.9 | 1.3 | -1.3 | 0.4 | 0.5 | -0.4 | -0.9 |
| Cocaine response before conditioning | 0.6 | 0.7 | 1.5 | 1.0 | -0.9 | 0.1 | -0.3 | -1.0 | 1.2 | -0.9 | 0.5 | 0.7 | -0.2 | -1.2 |
| Condit. Reinf. active-inactive response ratio | 0.6 | 0.7 | 2.0 | -0.8 | 0.9 | 0.0 | -0.1 | 0.9 | 0.0 | 0.8 | -0.9 | -1.4 | -1.0 | 0.7 |
| Locomotion velocity, session 7 | 0.6 | 0.7 | 1.9 | -1.1 | 0.7 | 0.8 | 1.4 | 0.9 | 0.2 | 0.8 | -0.1 | -1.0 | 0.4 | 1.0 |
| Bone: elastic work | 0.6 | 0.8 | 1.8 | 0.9 | -0.7 | 0.8 | 0.9 | -0.8 | 0.2 | -0.9 | 1.0 | 1.4 | 1.2 | -0.9 |
| Bone: endosteal estimation | 0.6 | 1.4 | 2.6 | -1.2 | 1.3 | 1.2 | 1.6 | 1.2 | 0.3 | 1.3 | -0.0 | -1.5 | 0.5 | 1.5 |
| Bone: trabecular number | 0.6 | 0.9 | 2.9 | 0.9 | -0.9 | 1.3 | 0.4 | -0.9 | 1.7 | -0.8 | 1.0 | 0.4 | 0.4 | -1.0 |
| Delta time in closed arm before/after self-admin | 0.6 | 0.6 | 2.2 | -0.2 | -0.2 | 1.1 | 1.5 | -0.1 | 0.0 | -0.0 | 0.6 | 0.6 | 1.5 | 0.0 |
| Delta time in open arm before/after self-admin | 0.6 | 0.5 | 2.3 | 0.6 | -0.2 | -1.0 | -1.5 | -0.2 | 0.4 | -0.2 | -0.4 | 0.1 | -1.3 | -0.5 |
| Liver weight, right | 0.5 | 0.9 | 3.7 | -0.1 | 0.2 | 1.6 | 1.9 | 0.2 | 0.2 | 0.3 | 0.9 | 0.2 | 1.5 | 0.3 |
| Delay discounting total patch changes 18 sec | 0.5 | 0.7 | 1.3 | 1.2 | -1.0 | 0.3 | 0.0 | -1.0 | 1.1 | -0.8 | 0.6 | 0.8 | -0.1 | -1.1 |
| Pavlov. Cond. lever latency | 0.5 | 0.7 | 2.9 | -0.9 | 0.7 | -0.8 | -0.1 | 0.7 | -1.7 | 0.8 | -0.7 | -0.4 | -0.1 | 1.0 |
| Stereotopy head waving duration, day 3 | 0.5 | 0.6 | 1.2 | -1.1 | 1.0 | 0.3 | 0.8 | 1.1 | -0.2 | 0.9 | -0.4 | -1.0 | 0.2 | 1.0 |
| Total locomotion distance, hab. session 2 | 0.5 | 0.7 | 2.8 | -0.2 | 0.0 | 1.5 | 1.7 | 0.2 | 0.6 | 0.0 | 0.7 | 0.1 | 1.2 | 0.4 |
| Novelty place preference | 0.5 | 0.5 | 1.0 | 0.9 | -0.8 | -0.0 | -0.8 | -0.7 | 1.0 | -0.8 | 0.3 | 0.3 | -0.5 | -1.0 |
| Bone: cortical area | 0.5 | 0.7 | 1.3 | 1.1 | -0.9 | 0.5 | 0.0 | -1.0 | 1.1 | -1.0 | 0.8 | 0.7 | 0.1 | -1.1 |
| Bone: cortical thickness | 0.5 | 0.6 | 1.4 | 0.7 | -0.8 | 0.3 | 0.8 | -0.7 | 0.3 | -0.7 | 0.9 | 1.2 | 1.0 | -0.8 |
| Bone: minimum diameter | 0.5 | 0.9 | 1.9 | -1.1 | 1.1 | 0.8 | 1.1 | 1.1 | 0.2 | 1.1 | -0.2 | -1.4 | 0.3 | 1.2 |
| Distance traveled before self-admin | 0.5 | 0.5 | 1.2 | 0.7 | -0.9 | 0.3 | -0.4 | -0.8 | 1.0 | -0.9 | 0.5 | 0.4 | -0.2 | -1.1 |
| Time in open arm before self-admin | 0.5 | 0.5 | 1.0 | -0.9 | 0.8 | 0.2 | 0.9 | 0.8 | -1.0 | 0.8 | -0.2 | -0.0 | 0.9 | 0.6 |
| Delay disc. indifference point, 4s delay | 0.5 | 0.5 | 1.7 | 0.0 | 0.2 | 1.1 | 1.3 | 0.1 | -0.2 | 0.3 | 0.7 | 0.5 | 1.3 | 0.1 |
| Left kidney weight | 0.4 | 1.1 | 2.0 | -1.2 | 1.3 | -0.5 | -0.6 | 1.3 | -0.5 | 1.4 | -1.2 | -1.4 | -1.0 | 0.9 |
| Food consumed during 24 hour testing period | 0.4 | 0.4 | 2.1 | 0.4 | -0.3 | -1.0 | -1.4 | -0.3 | -0.3 | -0.2 | -0.5 | -0.0 | -1.0 | -0.2 |
| Pavlov. Cond. lever contacts | 0.4 | 0.6 | 1.9 | 0.9 | -0.8 | 0.3 | -0.4 | -0.8 | 1.4 | -0.8 | 0.4 | 0.4 | -0.3 | -1.2 |
| Locomotion distance, session 7 | 0.4 | 0.6 | 2.8 | -0.6 | 0.3 | 1.0 | 1.7 | 0.4 | -0.0 | 0.3 | 0.4 | -0.1 | 1.1 | 0.6 |
| Locomotion distance, session 8 | 0.4 | 0.6 | 2.2 | -0.6 | 0.5 | 1.1 | 1.5 | 0.6 | 0.4 | 0.5 | 0.5 | -0.4 | 1.0 | 0.5 |
| Degree of sensitization distance | 0.4 | 0.4 | 1.7 | -0.3 | 0.1 | 0.9 | 1.3 | 0.2 | 0.5 | 0.1 | 0.4 | -0.1 | 0.8 | 0.4 |
| Degree of sensitization stereotypy | 0.4 | 0.5 | 1.5 | 0.6 | -0.8 | 0.2 | -0.5 | -0.8 | 1.2 | -0.7 | 0.4 | 0.1 | -0.2 | -1.0 |
| Condit. Reinf. lever presses | 0.4 | 0.5 | 1.4 | 0.7 | -0.6 | 1.1 | 0.7 | -0.5 | 1.2 | -0.6 | 0.8 | 0.5 | 0.6 | -0.5 |
| Total zone transitions, hab. session 1 | 0.4 | 0.6 | 1.1 | 0.8 | -1.1 | 0.5 | 0.2 | -1.0 | 0.8 | -1.0 | 0.8 | 0.8 | 0.5 | -0.8 |
| Locomotion velocity, hab. session 2 | 0.4 | 0.6 | 2.3 | -0.4 | 0.2 | 1.3 | 1.5 | 0.4 | 0.6 | 0.2 | 0.5 | -0.2 | 0.9 | 0.6 |
| Time in novel zone, NPP test | 0.4 | 0.4 | 0.9 | 0.8 | -0.7 | 0.1 | -0.6 | -0.6 | 0.8 | -0.6 | 0.4 | 0.3 | -0.3 | -1.0 |
| Total locomotion distance, NPP test | 0.4 | 0.5 | 1.6 | -0.0 | -0.2 | 1.2 | 1.3 | -0.1 | 0.7 | -0.3 | 0.7 | 0.2 | 1.1 | -0.0 |
| Pavlov. Cond. lever latency | 0.4 | 0.5 | 1.4 | -0.8 | 0.6 | -0.8 | -0.6 | 0.6 | -1.2 | 0.6 | -0.7 | -0.6 | -0.5 | 0.5 |
| Pavlov. Cond. magazine entry number | 0.4 | 0.4 | 1.1 | -0.8 | 0.6 | 0.5 | 1.0 | 0.7 | -0.7 | 0.7 | -0.0 | -0.4 | 0.7 | 0.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.4 | 0.5 | 1.2 | 0.9 | -0.7 | 0.2 | -0.3 | -0.7 | 1.1 | -0.8 | 0.5 | 0.6 | -0.0 | -0.7 |
| Bone: cortical porosity | 0.4 | 0.5 | 0.8 | 0.7 | -0.8 | 0.6 | 0.4 | -0.8 | 0.5 | -0.9 | 0.6 | 0.7 | 0.3 | -0.8 |
| Bone: trabecular thickness | 0.4 | 0.4 | 1.1 | -0.9 | 0.8 | 0.1 | -0.1 | 0.8 | -0.1 | 0.8 | -0.6 | -1.1 | -0.4 | 0.6 |
| Ambulatory time before self-admin | 0.4 | 0.4 | 1.3 | 0.6 | -0.6 | 0.1 | -0.7 | -0.6 | 0.7 | -0.7 | 0.1 | 0.1 | -0.8 | -1.2 |
| Delay disc. indifference point, 8s delay | 0.4 | 0.4 | 1.4 | 0.1 | 0.0 | 0.8 | 1.2 | -0.0 | -0.1 | 0.1 | 0.7 | 0.4 | 1.2 | 0.0 |
| Time >=10cm from walls, locomotor time 1 | 0.4 | 0.4 | 1.5 | -0.7 | 0.7 | 0.7 | 0.5 | 0.8 | 0.5 | 0.7 | -0.3 | -1.2 | -0.3 | 0.5 |
| Mg content in liver | 0.4 | 0.5 | 1.6 | 0.2 | -0.1 | 1.2 | 1.2 | -0.1 | 0.7 | -0.2 | 0.7 | 0.1 | 0.9 | -0.0 |
| Times rat made contact with spout | 0.3 | 0.4 | 1.0 | 0.8 | -0.7 | 0.2 | 0.1 | -0.7 | 0.2 | -0.7 | 0.5 | 1.0 | 0.4 | -0.6 |
| Reaction time num false alarms | 0.3 | 0.4 | 0.9 | -0.9 | 0.7 | -0.1 | 0.7 | 0.8 | -0.9 | 0.7 | -0.4 | -0.2 | 0.5 | 0.8 |
| Reaction time trials on left | 0.3 | 0.4 | 0.7 | 0.8 | -0.7 | 0.6 | 0.0 | -0.5 | 0.5 | -0.8 | 0.4 | 0.8 | 0.2 | -0.9 |
| Reaction time trials completed | 0.3 | 0.4 | 0.7 | 0.8 | -0.7 | 0.6 | 0.0 | -0.5 | 0.5 | -0.8 | 0.4 | 0.8 | 0.2 | -0.9 |
| Social responses | 0.3 | 0.4 | 1.1 | 0.8 | -0.6 | 0.1 | -0.3 | -0.5 | 0.8 | -0.7 | 0.4 | 1.0 | 0.1 | -0.8 |
| Social time | 0.3 | 0.4 | 1.0 | 0.9 | -0.7 | 0.2 | 0.1 | -0.4 | 0.5 | -0.8 | 0.6 | 1.0 | 0.5 | -0.8 |
| Condit. Reinf. inactive responses | 0.3 | 0.4 | 0.9 | 0.8 | -0.6 | 0.2 | 0.2 | -0.6 | 0.6 | -0.6 | 0.6 | 0.9 | 0.6 | -0.7 |
| Locomotion velocity, session 1 | 0.3 | 0.3 | 1.3 | -0.0 | -0.2 | 0.7 | 1.1 | -0.1 | 0.2 | -0.1 | 0.7 | 0.4 | 1.1 | 0.1 |
| Incentive salience index mean | 0.3 | 0.4 | 0.7 | 0.6 | -0.6 | 0.8 | 0.8 | -0.4 | 0.7 | -0.6 | 0.7 | 0.7 | 0.7 | -0.4 |
| Pavlov. Cond. magazine entry latency | 0.3 | 0.4 | 1.3 | 0.7 | -0.5 | 0.7 | 0.3 | -0.6 | 1.1 | -0.5 | 0.7 | 0.5 | 0.4 | -0.6 |
| Bone: trabecular spacing | 0.3 | 0.4 | 1.7 | -0.7 | 0.5 | -0.7 | 0.1 | 0.6 | -1.3 | 0.5 | -0.6 | -0.1 | -0.1 | 0.7 |
| Diff in mean of infusions in LGA sessions | 0.3 | 0.3 | 0.7 | 0.8 | -0.6 | 0.2 | -0.5 | -0.6 | 0.3 | -0.6 | 0.2 | 0.7 | -0.3 | -0.8 |
| Time in open arm after self-admin | 0.3 | 0.4 | 1.3 | -0.1 | 0.4 | -1.1 | -1.0 | 0.4 | -0.6 | 0.4 | -0.7 | -0.0 | -0.7 | 0.2 |
| Ambulatory time after self-admin | 0.3 | 0.4 | 1.3 | -0.3 | 0.4 | -0.8 | -1.1 | 0.3 | -0.1 | 0.3 | -0.6 | -0.7 | -0.9 | 0.1 |
| Area under the delay curve | 0.3 | 0.3 | 1.0 | 0.1 | 0.0 | 0.8 | 1.0 | -0.0 | -0.1 | 0.1 | 0.6 | 0.3 | 1.0 | 0.1 |
| Delay discount hyperbolic model param | 0.3 | 0.3 | 1.0 | -0.2 | 0.1 | -0.8 | -1.0 | 0.1 | 0.0 | -0.0 | -0.7 | -0.4 | -1.0 | -0.1 |
| Fecal boli incidents, locomotor time 1 | 0.3 | 0.3 | 1.5 | 0.4 | -0.3 | -0.4 | -0.8 | -0.3 | 1.2 | -0.2 | 0.0 | -0.1 | -0.7 | -0.4 |
| Time >=10cm from walls, locomotor time 2 | 0.3 | 0.3 | 1.3 | 0.3 | -0.4 | -0.7 | -1.1 | -0.1 | -0.0 | -0.2 | -0.4 | -0.3 | -1.0 | -0.3 |
| Bouts of movement, locomotor time 2 | 0.3 | 0.3 | 0.7 | 0.6 | -0.6 | -0.1 | -0.6 | -0.8 | 0.2 | -0.6 | 0.2 | 0.6 | -0.2 | -0.7 |
| Food seeking constrained by brief footshock | 0.3 | 0.3 | 1.0 | 0.3 | -0.2 | 0.7 | 0.8 | -0.4 | 0.1 | -0.2 | 0.7 | 0.8 | 1.0 | -0.1 |
| Se content in liver | 0.3 | 0.4 | 1.8 | 0.2 | 0.1 | -0.4 | -1.3 | -0.0 | 0.3 | 0.0 | -0.5 | -0.6 | -1.3 | -0.0 |
| Right kidney weight | 0.2 | 0.5 | 1.4 | -0.5 | 0.5 | -0.6 | -0.9 | 0.5 | -0.2 | 0.6 | -0.8 | -1.0 | -1.2 | -0.0 |
| Number of licking bursts | 0.2 | 0.2 | 0.4 | 0.6 | -0.7 | 0.1 | -0.3 | -0.7 | 0.5 | -0.5 | 0.3 | 0.4 | 0.0 | -0.6 |
| Std. dev. time between licks in bursts | 0.2 | 0.3 | 0.7 | -0.5 | 0.5 | 0.3 | 0.8 | 0.5 | -0.7 | 0.3 | 0.1 | 0.3 | 0.8 | 0.3 |
| Light reinforcement 1 | 0.2 | 0.3 | 0.5 | -0.5 | 0.4 | -0.7 | -0.6 | 0.3 | -0.6 | 0.5 | -0.7 | -0.4 | -0.7 | 0.0 |
| Reaction time number correct | 0.2 | 0.3 | 0.6 | 0.7 | -0.6 | 0.6 | 0.0 | -0.4 | 0.5 | -0.7 | 0.4 | 0.8 | 0.2 | -0.8 |
| Reaction time trials correct on left | 0.2 | 0.3 | 0.6 | 0.7 | -0.6 | 0.6 | 0.0 | -0.4 | 0.5 | -0.7 | 0.4 | 0.8 | 0.2 | -0.8 |
| Reaction time mean | 0.2 | 0.2 | 0.8 | 0.3 | -0.2 | -0.6 | -0.9 | 0.1 | 0.4 | -0.4 | -0.2 | -0.4 | -0.7 | -0.4 |
| Reaction time mean AUC | 0.2 | 0.2 | 0.8 | 0.2 | -0.1 | -0.5 | -0.9 | 0.1 | 0.4 | -0.3 | -0.2 | -0.4 | -0.7 | -0.4 |
| Median of all reaction times | 0.2 | 0.3 | 0.8 | -0.2 | 0.3 | -0.6 | -0.9 | 0.5 | -0.1 | 0.1 | -0.5 | -0.8 | -0.7 | 0.0 |
| Reaction time false alarm rate | 0.2 | 0.4 | 0.7 | -0.8 | 0.6 | -0.0 | 0.8 | 0.6 | -0.7 | 0.6 | -0.2 | -0.1 | 0.6 | 0.7 |
| Reaction time trials AUC | 0.2 | 0.3 | 0.5 | 0.6 | -0.5 | 0.7 | 0.2 | -0.3 | 0.4 | -0.6 | 0.4 | 0.7 | 0.3 | -0.7 |
| Condit. Reinf. active minus inactive responses | 0.2 | 0.2 | 0.7 | -0.3 | 0.5 | -0.2 | -0.3 | 0.5 | 0.3 | 0.4 | -0.6 | -0.8 | -0.8 | 0.2 |
| Condit. Reinf. lever reinforcers received | 0.2 | 0.3 | 0.8 | 0.7 | -0.5 | 0.1 | -0.3 | -0.5 | 0.9 | -0.5 | 0.1 | 0.2 | -0.4 | -0.7 |
| Condit. Reinf. inactive responses | 0.2 | 0.2 | 0.7 | -0.5 | 0.2 | 0.8 | 0.7 | 0.4 | 0.5 | 0.3 | 0.1 | -0.5 | 0.2 | 0.4 |
| Time in familiar zone, hab. session 1 | 0.2 | 0.2 | 0.3 | -0.4 | 0.5 | 0.1 | 0.5 | 0.4 | -0.0 | 0.6 | -0.3 | -0.5 | -0.0 | 0.5 |
| Time in novel zone, hab. session 1 | 0.2 | 0.2 | 0.9 | -0.5 | 0.4 | -0.1 | 0.1 | 0.4 | -1.0 | 0.3 | -0.1 | -0.0 | 0.4 | 0.4 |
| Total locomotion distance, hab. session 1 | 0.2 | 0.3 | 0.6 | -0.7 | 0.6 | 0.5 | 0.8 | 0.6 | -0.0 | 0.6 | -0.1 | -0.7 | 0.3 | 0.8 |
| Time in familiar zone, hab. session 2 | 0.2 | 0.2 | 0.6 | 0.1 | 0.1 | 0.4 | 0.7 | -0.0 | -0.3 | 0.2 | 0.3 | 0.6 | 0.8 | -0.0 |
| Locomotion velocity, NPP test | 0.2 | 0.3 | 0.8 | 0.1 | -0.3 | 0.9 | 0.9 | -0.2 | 0.7 | -0.3 | 0.5 | 0.1 | 0.7 | 0.0 |
| Pavlov. Cond. change in total contacts | 0.2 | 0.2 | 0.6 | 0.3 | -0.3 | -0.3 | -0.7 | -0.2 | 0.7 | -0.2 | -0.1 | -0.2 | -0.7 | -0.0 |
| Pavlov. Cond. index score | 0.2 | 0.2 | 0.7 | 0.7 | -0.5 | 0.0 | -0.4 | -0.5 | 0.8 | -0.5 | 0.2 | 0.4 | -0.2 | -0.5 |
| Bone: cortical apparent density | 0.2 | 0.2 | 0.6 | 0.5 | -0.5 | -0.8 | -0.6 | -0.4 | -0.0 | -0.6 | -0.0 | 0.6 | -0.3 | -0.5 |
| Bone: cortical tissue density | 0.2 | 0.3 | 0.6 | 0.6 | -0.6 | -0.8 | -0.6 | -0.5 | -0.0 | -0.7 | 0.0 | 0.7 | -0.3 | -0.6 |
| Bone: maximum diameter | 0.2 | 0.3 | 1.3 | 0.7 | -0.5 | 0.5 | -0.2 | -0.6 | 1.2 | -0.6 | 0.5 | -0.0 | -0.2 | -0.6 |
| Bone: periosteal estimation | 0.2 | 0.4 | 1.2 | -0.0 | 0.1 | 1.0 | 0.9 | 0.1 | 1.1 | 0.1 | 0.5 | -0.5 | 0.3 | 0.2 |
| Bone: periosteal perimeter | 0.2 | 0.3 | 1.2 | 0.4 | -0.4 | 0.8 | 0.5 | -0.3 | 1.1 | -0.3 | 0.6 | -0.1 | 0.2 | -0.4 |
| Distance traveled after self-admin | 0.2 | 0.2 | 1.1 | 0.4 | -0.4 | -0.5 | -1.0 | -0.4 | 0.2 | -0.5 | -0.1 | 0.1 | -0.6 | -0.6 |
| Time in closed arm after self-admin | 0.2 | 0.2 | 0.8 | -0.5 | 0.2 | 0.5 | 0.9 | 0.2 | -0.2 | 0.3 | 0.0 | -0.1 | 0.6 | 0.5 |
| Delay discount exponential model param | 0.2 | 0.3 | 0.9 | -0.2 | 0.0 | -0.7 | -0.9 | 0.1 | 0.1 | -0.1 | -0.6 | -0.4 | -0.9 | -0.1 |
| Latency to leave start box in cocaine runway, M | 0.2 | 0.2 | 0.8 | -0.5 | 0.3 | 0.3 | 0.9 | 0.3 | 0.1 | 0.1 | 0.3 | -0.4 | 0.6 | 0.8 |
| Cu content in liver | 0.2 | 0.2 | 0.5 | 0.7 | -0.6 | -0.0 | -0.5 | -0.6 | -0.2 | -0.6 | 0.3 | 0.6 | -0.0 | -0.4 |
| Fe content in liver | 0.2 | 0.2 | 0.5 | 0.7 | -0.4 | 0.4 | 0.3 | -0.5 | 0.6 | -0.4 | 0.5 | 0.4 | 0.2 | -0.4 |
| Liver weight, left | 0.1 | 0.2 | 0.9 | -0.3 | 0.2 | 0.6 | 1.0 | 0.2 | 0.7 | 0.2 | 0.3 | -0.2 | 0.6 | 0.2 |
| Mean num. licks in bursts | 0.1 | 0.2 | 0.4 | -0.4 | 0.5 | -0.3 | 0.1 | 0.5 | -0.6 | 0.4 | -0.4 | -0.1 | -0.1 | 0.5 |
| Indifference point 0 sec | 0.1 | 0.1 | 0.2 | -0.4 | 0.2 | -0.0 | -0.2 | 0.1 | -0.5 | 0.2 | -0.4 | -0.4 | -0.4 | -0.2 |
| Reaction time num false alarms AUC | 0.1 | 0.2 | 0.8 | -0.1 | -0.0 | 0.4 | 0.9 | 0.1 | -0.4 | -0.0 | 0.2 | 0.5 | 0.8 | 0.0 |
| Condit. Reinf. active responses | 0.1 | 0.1 | 0.4 | 0.3 | -0.0 | 0.1 | -0.2 | -0.1 | 0.6 | -0.2 | -0.1 | -0.1 | -0.4 | -0.3 |
| Locomotion distance, session 3 | 0.1 | 0.1 | 0.5 | -0.3 | 0.3 | 0.5 | 0.7 | 0.3 | -0.2 | 0.2 | 0.2 | -0.1 | 0.5 | 0.2 |
| Stereotopy head waving bouts, day 7 | 0.1 | 0.1 | 0.6 | -0.4 | 0.3 | -0.0 | -0.3 | 0.3 | 0.4 | 0.3 | -0.3 | -0.8 | -0.5 | 0.1 |
| Condit. Reinf. active minus inactive responses | 0.1 | 0.1 | 0.2 | 0.4 | -0.4 | 0.1 | 0.3 | -0.2 | 0.2 | -0.4 | 0.3 | 0.5 | 0.2 | -0.3 |
| Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 0.4 | 0.2 | -0.1 | -0.7 | -0.5 | -0.0 | -0.4 | -0.2 | -0.2 | 0.2 | -0.4 | -0.1 |
| Locomotion velocity, hab. session 1 | 0.1 | 0.1 | 0.4 | -0.2 | 0.1 | 0.5 | 0.6 | 0.2 | 0.2 | 0.1 | 0.1 | -0.2 | 0.3 | 0.3 |
| Pavlov. Cond. latency score | 0.1 | 0.2 | 0.7 | 0.5 | -0.3 | 0.3 | 0.0 | -0.3 | 0.8 | -0.3 | 0.3 | 0.4 | 0.1 | -0.3 |
| Pavlov. Cond. lever contacts | 0.1 | 0.1 | 0.3 | 0.3 | -0.1 | 0.5 | 0.5 | -0.1 | 0.6 | -0.1 | 0.4 | 0.3 | 0.4 | -0.0 |
| Pavlov. Cond. response bias | 0.1 | 0.2 | 0.3 | 0.6 | -0.4 | -0.3 | -0.5 | -0.4 | 0.6 | -0.4 | 0.1 | 0.3 | -0.4 | -0.5 |
| Bone: tissue strength | 0.1 | 0.1 | 0.3 | -0.1 | 0.1 | -0.3 | -0.4 | 0.0 | 0.1 | -0.1 | -0.3 | -0.3 | -0.6 | -0.0 |
| Delta distance traveled before/after self-admin | 0.1 | 0.1 | 0.3 | -0.1 | 0.3 | -0.2 | -0.1 | 0.2 | -0.6 | 0.2 | -0.1 | 0.0 | 0.2 | 0.2 |
| Delta ambulatory time before/after self-admin | 0.1 | 0.1 | 0.3 | -0.0 | 0.2 | -0.1 | 0.1 | 0.1 | -0.4 | 0.1 | 0.1 | 0.2 | 0.5 | 0.2 |
| Time in closed arm before self-admin | 0.1 | 0.1 | 0.3 | 0.4 | -0.2 | 0.0 | -0.2 | -0.2 | 0.6 | -0.2 | 0.1 | -0.1 | -0.4 | -0.3 |
| Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.4 | 0.3 | -0.0 | 0.2 | -0.0 | -0.1 | 0.6 | -0.2 | 0.3 | 0.4 | 0.2 | -0.6 |
| Delay disc. indifference point, 2s delay | 0.1 | 0.1 | 0.4 | -0.1 | 0.1 | 0.3 | 0.6 | 0.1 | 0.2 | 0.3 | 0.4 | 0.0 | 0.7 | 0.5 |
| Delay disc. indifference point, 24s delay | 0.1 | 0.1 | 0.9 | -0.0 | 0.2 | 0.0 | 0.4 | 0.2 | -1.0 | 0.2 | 0.0 | 0.3 | 0.3 | 0.3 |
| Total resting periods, locomotor time 2 | 0.1 | 0.1 | 0.3 | 0.4 | -0.3 | -0.1 | -0.5 | -0.6 | 0.1 | -0.4 | 0.1 | 0.3 | -0.2 | -0.5 |
| Vertical activity count, locomotor time 2 | 0.1 | 0.1 | 0.2 | -0.0 | 0.0 | -0.3 | -0.2 | 0.3 | -0.4 | 0.1 | -0.3 | 0.3 | -0.1 | -0.0 |
| Seeking ratio, delayed vs. immediate footshock | 0.1 | 0.1 | 0.3 | -0.5 | 0.3 | -0.5 | -0.3 | 0.4 | -0.3 | 0.3 | -0.4 | -0.1 | -0.2 | 0.3 |
| Run reversals in cocaine runway, males | 0.1 | 0.1 | 0.4 | -0.2 | 0.6 | -0.3 | -0.1 | 0.6 | -0.3 | 0.6 | -0.3 | -0.0 | -0.1 | 0.4 |
| Latency to leave start box in cocaine runway | 0.1 | 0.1 | 0.4 | -0.4 | 0.1 | -0.1 | 0.4 | 0.2 | 0.4 | 0.2 | 0.1 | -0.4 | 0.3 | 0.7 |
| Delay discounting total patch changes 0 sec | 0.0 | 0.1 | 0.4 | -0.3 | 0.1 | 0.0 | -0.2 | 0.0 | -0.6 | 0.1 | -0.3 | -0.2 | -0.3 | -0.3 |
| Cocaine induced anxiety | 0.0 | 0.0 | 0.1 | 0.3 | -0.1 | 0.0 | -0.2 | -0.1 | -0.1 | -0.1 | 0.0 | -0.1 | -0.3 | 0.3 |
| Condit. Reinf. active responses | 0.0 | 0.0 | 0.1 | 0.0 | -0.1 | 0.3 | 0.3 | 0.1 | 0.2 | -0.1 | 0.1 | 0.0 | 0.0 | 0.1 |
| Time in novel zone, hab. session 2 | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | -0.1 | -0.3 | -0.1 | 0.2 | -0.3 | 0.1 | -0.1 | -0.2 | -0.1 |
| Bone: cortical porosity | 0.0 | 0.0 | 0.1 | 0.1 | -0.3 | 0.3 | 0.2 | -0.3 | -0.0 | -0.3 | 0.1 | 0.1 | 0.0 | -0.1 |
| Latency to leave start box in cocaine runway, F | 0.0 | 0.0 | 0.2 | 0.0 | -0.2 | -0.4 | -0.3 | -0.1 | 0.4 | -0.0 | -0.0 | -0.1 | -0.1 | 0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.