# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | mRNA stability | ENSRNOG00000059961 | 0.0620 | 0.0470 | 1.9e-07 | 0.046 | 0.054 | 0.049 | 0.047 | 7.4e-06 | 1.3e-06 | 3.4e-06 | 5.4e-06 |
2 | BLA | alternative TSS | ENSRNOT00000078644 | 0.0784 | 0.0717 | 4.5e-04 | 0.064 | 0.008 | 0.059 | 0.007 | 2.6e-04 | 1.2e-01 | 4.3e-04 | 1.3e-01 |
3 | BLA | alternative TSS | ENSRNOT00000096691 | 0.0751 | 0.0695 | 6.3e-04 | 0.060 | 0.007 | 0.055 | 0.006 | 3.7e-04 | 1.4e-01 | 6.7e-04 | 1.5e-01 |
4 | BLA | isoform ratio | ENSRNOT00000083182 | 0.0510 | 0.0480 | 4.1e-03 | 0.025 | 0.012 | 0.024 | 0.006 | 1.7e-02 | 6.8e-02 | 1.8e-02 | 1.4e-01 |
5 | BLA | isoform ratio | ENSRNOT00000096691 | 0.0640 | 0.0730 | 4.9e-03 | 0.032 | 0.014 | 0.018 | 0.013 | 7.7e-03 | 5.9e-02 | 3.6e-02 | 6.1e-02 |
6 | Brain | alternative TSS | ENSRNOT00000078644 | 0.1715 | 0.0860 | 0.0e+00 | 0.227 | 0.237 | 0.232 | 0.226 | 8.0e-21 | 8.0e-22 | 2.5e-21 | 1.0e-20 |
7 | Brain | alternative TSS | ENSRNOT00000096691 | 0.1696 | 0.0851 | 0.0e+00 | 0.225 | 0.237 | 0.228 | 0.225 | 1.2e-20 | 8.9e-22 | 6.3e-21 | 1.3e-20 |
8 | Brain | gene expression | ENSRNOG00000059961 | 0.1300 | 0.0900 | 1.8e-14 | 0.155 | 0.151 | 0.150 | 0.155 | 3.0e-14 | 7.0e-14 | 8.6e-14 | 3.0e-14 |
9 | Brain | isoform ratio | ENSRNOT00000083182 | 0.0715 | 0.0549 | 1.3e-06 | 0.042 | 0.052 | 0.034 | 0.044 | 7.9e-05 | 1.2e-05 | 4.0e-04 | 5.8e-05 |
10 | Brain | isoform ratio | ENSRNOT00000096691 | 0.0737 | 0.0488 | 8.8e-09 | 0.085 | 0.085 | 0.083 | 0.082 | 2.6e-08 | 2.9e-08 | 4.0e-08 | 5.0e-08 |
11 | Brain | isoform ratio | ENSRNOT00000098812 | 0.0300 | 0.0339 | 7.5e-03 | 0.025 | 0.014 | 0.018 | 0.018 | 2.2e-03 | 1.7e-02 | 7.5e-03 | 7.5e-03 |
12 | Brain | intron excision ratio | chr7:128884674:128885915 | 0.0295 | 0.0307 | 4.8e-03 | 0.018 | 0.019 | 0.021 | 0.014 | 8.4e-03 | 6.3e-03 | 4.4e-03 | 1.6e-02 |
13 | IL | alternative TSS | ENSRNOT00000096691 | 0.2180 | 0.1270 | 1.2e-05 | 0.167 | 0.239 | 0.191 | 0.204 | 8.0e-05 | 1.9e-06 | 2.4e-05 | 1.2e-05 |
14 | LHb | alternative TSS | ENSRNOT00000078644 | 0.3520 | 0.1860 | 4.6e-07 | 0.252 | 0.245 | 0.242 | 0.228 | 1.1e-06 | 1.6e-06 | 1.8e-06 | 3.9e-06 |
15 | LHb | alternative TSS | ENSRNOT00000096691 | 0.5270 | 0.2060 | 6.1e-08 | 0.202 | 0.249 | 0.216 | 0.205 | 1.5e-05 | 1.3e-06 | 7.2e-06 | 1.3e-05 |
16 | LHb | gene expression | ENSRNOG00000059961 | 0.3274 | 0.2288 | 1.6e-04 | 0.105 | 0.145 | 0.080 | 0.083 | 1.8e-03 | 2.7e-04 | 6.1e-03 | 5.3e-03 |
17 | LHb | isoform ratio | ENSRNOT00000083182 | 0.1926 | 0.1426 | 4.3e-04 | 0.163 | 0.132 | 0.095 | 0.124 | 1.1e-04 | 5.0e-04 | 3.0e-03 | 7.3e-04 |
18 | LHb | isoform ratio | ENSRNOT00000096691 | 0.1744 | 0.1463 | 1.3e-03 | 0.148 | 0.137 | 0.157 | 0.120 | 2.4e-04 | 4.0e-04 | 1.5e-04 | 9.1e-04 |
19 | LHb | intron excision ratio | chr7:128879272:128880061 | 0.1430 | 0.1130 | 2.5e-03 | 0.094 | 0.115 | 0.125 | 0.080 | 3.1e-03 | 1.1e-03 | 7.1e-04 | 6.1e-03 |
20 | NAcc | alternative TSS | ENSRNOT00000078644 | 0.1380 | 0.0980 | 3.1e-09 | 0.088 | 0.095 | 0.097 | 0.090 | 4.3e-07 | 1.5e-07 | 1.0e-07 | 3.2e-07 |
21 | NAcc | alternative TSS | ENSRNOT00000096691 | 0.1730 | 0.1770 | 5.3e-07 | 0.075 | 0.073 | 0.063 | 0.073 | 2.9e-06 | 4.3e-06 | 1.8e-05 | 4.3e-06 |
22 | NAcc | isoform ratio | ENSRNOT00000083182 | 0.1220 | 0.4187 | 3.8e-03 | 0.032 | 0.009 | 0.033 | 0.022 | 1.8e-03 | 6.3e-02 | 1.6e-03 | 8.0e-03 |
23 | NAcc | isoform ratio | ENSRNOT00000096691 | 0.0439 | 0.0418 | 1.9e-03 | 0.037 | 0.029 | 0.029 | 0.033 | 8.4e-04 | 2.8e-03 | 3.0e-03 | 1.7e-03 |
24 | OFC | alternative TSS | ENSRNOT00000096691 | 0.1960 | 0.1170 | 7.7e-05 | 0.125 | 0.163 | 0.127 | 0.125 | 7.0e-04 | 1.1e-04 | 6.4e-04 | 7.2e-04 |
25 | PL | alternative TSS | ENSRNOT00000078644 | 0.1200 | 0.0750 | 1.3e-11 | 0.126 | 0.135 | 0.117 | 0.125 | 8.0e-10 | 1.9e-10 | 3.2e-09 | 9.8e-10 |
26 | PL | alternative TSS | ENSRNOT00000096691 | 0.1700 | 0.1100 | 5.2e-14 | 0.173 | 0.171 | 0.167 | 0.166 | 4.0e-13 | 4.9e-13 | 1.1e-12 | 1.2e-12 |
27 | PL | isoform ratio | ENSRNOT00000083182 | 0.0670 | 0.0500 | 7.5e-06 | 0.059 | 0.070 | 0.046 | 0.061 | 2.7e-05 | 5.4e-06 | 1.9e-04 | 2.1e-05 |
28 | PL | isoform ratio | ENSRNOT00000096691 | 0.0920 | 0.0600 | 1.2e-08 | 0.107 | 0.105 | 0.099 | 0.098 | 1.8e-08 | 2.4e-08 | 5.7e-08 | 7.2e-08 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bone: stiffness | 14.9 | 23.6 | 27.7 | 5.0 | -4.6 | 4.6 | -4.4 | 5.3 | -5.0 | 5.0 | 5.0 | -5.0 | 5.0 | -5.0 | 5.0 | 5.0 | -4.9 | 5.0 | 4.8 | -5.0 | 3.9 | -4.9 | -4.8 | 4.6 | -4.4 | 4.6 | 5.0 | -5.0 | 5.1 | -5.0 | 5.0 |
Bone: maximum force | 12.2 | 21.2 | 25.8 | 4.7 | -4.4 | 4.4 | -4.3 | 5.1 | -4.7 | 4.7 | 4.7 | -4.7 | 4.7 | -4.7 | 4.8 | 4.7 | -4.7 | 4.7 | 4.5 | -4.7 | 3.6 | -4.6 | -4.7 | 4.5 | -4.3 | 4.5 | 4.7 | -4.7 | 4.8 | -4.7 | 4.7 |
Bone: maximum moment | 12.1 | 21.1 | 25.9 | 4.7 | -4.3 | 4.3 | -4.3 | 5.1 | -4.7 | 4.7 | 4.7 | -4.7 | 4.7 | -4.7 | 4.8 | 4.7 | -4.7 | 4.6 | 4.5 | -4.7 | 3.6 | -4.6 | -4.7 | 4.5 | -4.3 | 4.5 | 4.7 | -4.7 | 4.8 | -4.7 | 4.7 |
Bone: periosteal estimation | 11.8 | 24.0 | 26.3 | 5.0 | -4.7 | 4.7 | -4.7 | 5.1 | -5.0 | 5.0 | 5.0 | -5.0 | 5.0 | -5.0 | 5.0 | 5.0 | -4.9 | 5.0 | 4.9 | -5.0 | 4.2 | -5.0 | -4.9 | 4.8 | -4.7 | 4.8 | 5.0 | -5.0 | 5.0 | -5.0 | 5.0 |
Bone: periosteal perimeter | 10.7 | 17.7 | 19.2 | 4.3 | -4.1 | 4.1 | -4.0 | 4.3 | -4.3 | 4.3 | 4.3 | -4.3 | 4.3 | -4.3 | 4.3 | 4.3 | -4.2 | 4.3 | 4.3 | -4.3 | 3.5 | -4.3 | -4.2 | 3.9 | -4.0 | 4.0 | 4.3 | -4.3 | 4.2 | -4.3 | 4.4 |
Bone surface | 10.0 | 17.6 | 21.5 | 4.2 | -4.1 | 4.1 | -4.0 | 4.6 | -4.3 | 4.3 | 4.2 | -4.2 | 4.2 | -4.2 | 4.6 | 4.3 | -4.2 | 4.1 | 4.1 | -4.3 | 2.6 | -4.2 | -4.4 | 4.2 | -4.0 | 4.2 | 4.2 | -4.3 | 4.5 | -4.3 | 4.2 |
Intraocular pressure | 9.8 | 13.8 | 16.8 | -3.8 | 3.2 | -3.2 | 3.2 | -3.4 | 3.9 | -3.9 | -4.0 | 3.8 | -4.0 | 4.0 | -3.5 | -3.9 | 4.1 | -3.9 | -4.1 | 4.0 | -4.1 | 4.0 | 3.3 | -2.9 | 3.2 | -3.1 | -4.0 | 3.8 | -3.4 | 3.8 | -4.1 |
Bone: cortical area | 9.7 | 14.7 | 16.6 | 3.9 | -3.6 | 3.6 | -3.7 | 4.1 | -3.9 | 3.9 | 3.9 | -3.9 | 3.9 | -3.9 | 4.1 | 3.9 | -3.8 | 3.9 | 3.7 | -3.9 | 2.9 | -3.8 | -4.0 | 3.8 | -3.7 | 3.8 | 3.9 | -3.9 | 4.0 | -3.9 | 3.9 |
Bone: final moment | 9.7 | 15.9 | 18.7 | 4.0 | -3.8 | 3.8 | -3.8 | 4.2 | -4.1 | 4.1 | 4.0 | -4.0 | 4.0 | -4.0 | 4.3 | 4.1 | -4.1 | 3.9 | 4.0 | -4.1 | 3.0 | -4.0 | -4.1 | 4.0 | -3.8 | 4.1 | 4.1 | -4.1 | 4.1 | -4.1 | 4.1 |
Reaction time omissions | 9.6 | 13.0 | 14.5 | -3.7 | 3.7 | -3.7 | 3.0 | -3.7 | 3.7 | -3.7 | -3.8 | 3.7 | -3.8 | 3.8 | -3.4 | -3.7 | 3.5 | -3.7 | -3.6 | 3.8 | -3.2 | 3.7 | 3.6 | -3.7 | 2.8 | -3.5 | -3.7 | 3.6 | -3.6 | 3.7 | -3.7 |
Bone: final force | 9.6 | 15.8 | 18.1 | 4.0 | -3.7 | 3.7 | -3.8 | 4.2 | -4.0 | 4.0 | 4.0 | -4.0 | 4.0 | -4.0 | 4.3 | 4.0 | -4.1 | 3.9 | 4.0 | -4.1 | 3.0 | -4.0 | -4.0 | 4.0 | -3.8 | 4.0 | 4.0 | -4.1 | 4.1 | -4.1 | 4.1 |
Reaction time mean minus median | 9.2 | 12.0 | 13.2 | -3.6 | 3.5 | -3.5 | 3.3 | -3.4 | 3.5 | -3.5 | -3.6 | 3.6 | -3.6 | 3.6 | -3.1 | -3.5 | 3.3 | -3.6 | -3.5 | 3.5 | -3.5 | 3.4 | 3.5 | -3.5 | 3.1 | -3.4 | -3.5 | 3.5 | -3.3 | 3.5 | -3.4 |
Social responses | 9.1 | 11.8 | 15.4 | -3.4 | 3.7 | -3.7 | 3.9 | -3.3 | 3.4 | -3.4 | -3.2 | 3.3 | -3.2 | 3.2 | -3.8 | -3.3 | 3.4 | -3.2 | -3.4 | 3.4 | -2.1 | 3.4 | 3.7 | -3.8 | 3.9 | -3.8 | -3.4 | 3.5 | -3.5 | 3.4 | -3.3 |
Bone: post-yield work | 8.6 | 11.6 | 14.4 | 3.4 | -3.3 | 3.3 | -3.4 | 3.4 | -3.4 | 3.4 | 3.4 | -3.5 | 3.4 | -3.4 | 3.2 | 3.4 | -3.4 | 3.5 | 3.5 | -3.5 | 3.8 | -3.5 | -3.4 | 3.4 | -3.4 | 3.4 | 3.5 | -3.4 | 3.1 | -3.4 | 3.5 |
Length without tail | 7.8 | 17.1 | 19.5 | 4.1 | -3.9 | 3.9 | -4.1 | 4.0 | -4.3 | 4.3 | 4.3 | -4.1 | 4.3 | -4.3 | 4.3 | 4.2 | -4.4 | 4.1 | 4.3 | -4.3 | 3.4 | -4.3 | -4.0 | 4.0 | -3.8 | 3.9 | 4.3 | -4.2 | 4.1 | -4.2 | 4.3 |
Bone: minimum diameter | 7.7 | 14.2 | 18.0 | 3.9 | -3.6 | 3.6 | -3.5 | 4.2 | -3.8 | 3.8 | 3.8 | -3.9 | 3.8 | -3.8 | 3.8 | 3.9 | -3.7 | 3.9 | 3.6 | -3.9 | 3.0 | -3.8 | -3.8 | 3.5 | -3.5 | 3.5 | 3.8 | -3.9 | 4.1 | -3.9 | 3.8 |
Bone: marrow area | 7.5 | 16.0 | 17.3 | 4.1 | -4.0 | 4.0 | -3.7 | 4.0 | -4.1 | 4.1 | 4.0 | -4.1 | 4.0 | -4.0 | 3.8 | 4.1 | -4.0 | 4.2 | 4.1 | -4.1 | 4.0 | -4.1 | -3.9 | 3.9 | -3.7 | 3.8 | 4.1 | -4.0 | 3.8 | -4.1 | 4.1 |
Bone: endosteal estimation | 7.4 | 15.9 | 17.1 | 4.1 | -3.9 | 3.9 | -3.7 | 4.1 | -4.1 | 4.1 | 4.0 | -4.1 | 4.0 | -4.0 | 3.8 | 4.1 | -4.0 | 4.1 | 4.1 | -4.1 | 3.9 | -4.1 | -3.9 | 3.9 | -3.7 | 3.8 | 4.1 | -4.0 | 3.8 | -4.1 | 4.1 |
Bone: apparent density | 7.3 | 12.1 | 17.2 | 3.5 | -3.2 | 3.2 | -3.2 | 4.1 | -3.6 | 3.6 | 3.4 | -3.5 | 3.4 | -3.4 | 4.1 | 3.6 | -3.5 | 3.4 | 3.3 | -3.5 | 1.5 | -3.4 | -3.7 | 3.4 | -3.2 | 3.4 | 3.5 | -3.6 | 4.1 | -3.6 | 3.5 |
Body weight | 7.0 | 29.8 | 33.4 | 5.6 | -5.1 | 5.1 | -4.8 | 5.8 | -5.7 | 5.7 | 5.7 | -5.6 | 5.7 | -5.7 | 5.5 | 5.7 | -5.6 | 5.6 | 5.5 | -5.7 | 4.4 | -5.6 | -5.3 | 5.1 | -4.6 | 5.0 | 5.7 | -5.6 | 5.6 | -5.7 | 5.8 |
Std. dev. reaction times | 6.8 | 9.4 | 11.4 | -3.2 | 3.1 | -3.1 | 2.7 | -2.9 | 3.1 | -3.1 | -3.2 | 3.2 | -3.2 | 3.2 | -2.7 | -3.1 | 2.9 | -3.2 | -3.1 | 3.2 | -3.4 | 3.1 | 3.0 | -3.1 | 2.4 | -3.0 | -3.1 | 3.1 | -2.8 | 3.1 | -3.1 |
Reaction time mean minus median AUC | 6.7 | 8.6 | 9.6 | -3.1 | 2.9 | -2.9 | 2.7 | -2.8 | 3.0 | -3.0 | -3.1 | 3.1 | -3.1 | 3.1 | -2.6 | -3.0 | 2.8 | -3.1 | -3.0 | 3.0 | -3.1 | 2.9 | 2.9 | -2.9 | 2.5 | -2.7 | -3.0 | 3.0 | -2.7 | 3.0 | -3.0 |
Bone: endosteal perimeter | 6.7 | 13.7 | 15.3 | 3.8 | -3.5 | 3.5 | -3.4 | 3.9 | -3.8 | 3.8 | 3.8 | -3.8 | 3.8 | -3.8 | 3.6 | 3.8 | -3.7 | 3.9 | 3.7 | -3.9 | 3.3 | -3.8 | -3.7 | 3.5 | -3.4 | 3.4 | 3.8 | -3.8 | 3.8 | -3.8 | 3.8 |
Bone volume | 6.4 | 10.9 | 15.4 | 3.4 | -3.0 | 3.0 | -3.0 | 3.9 | -3.4 | 3.4 | 3.3 | -3.4 | 3.3 | -3.3 | 3.8 | 3.4 | -3.3 | 3.3 | 3.1 | -3.4 | 1.6 | -3.3 | -3.5 | 3.2 | -3.0 | 3.2 | 3.3 | -3.4 | 3.8 | -3.5 | 3.4 |
Cocaine response before conditioning | 6.3 | 7.6 | 9.5 | -2.8 | 2.7 | -2.7 | 2.6 | -2.2 | 2.9 | -2.9 | -2.9 | 2.7 | -2.9 | 2.9 | -2.8 | -2.8 | 2.9 | -2.8 | -3.1 | 3.0 | -2.6 | 3.0 | 2.6 | -2.5 | 2.6 | -2.5 | -2.9 | 2.8 | -2.5 | 2.8 | -3.0 |
Extensor digitorum longus weight | 6.2 | 24.8 | 27.5 | 5.1 | -4.8 | 4.8 | -4.7 | 4.8 | -5.1 | 5.1 | 5.0 | -5.0 | 5.0 | -5.0 | 4.4 | 5.0 | -5.2 | 5.1 | 5.2 | -5.0 | 5.1 | -5.2 | -4.8 | 4.9 | -4.7 | 4.9 | 5.1 | -5.0 | 4.5 | -5.0 | 5.2 |
Tibia length | 6.0 | 16.8 | 22.7 | 4.2 | -4.1 | 4.1 | -3.8 | 4.8 | -4.2 | 4.2 | 4.1 | -4.3 | 4.1 | -4.1 | 4.3 | 4.2 | -4.0 | 4.2 | 3.8 | -4.0 | 2.7 | -3.9 | -4.3 | 4.2 | -3.9 | 4.0 | 4.1 | -4.2 | 4.6 | -4.3 | 4.0 |
Bone: connectivity density | 5.6 | 8.8 | 12.8 | 2.9 | -2.8 | 2.8 | -2.9 | 3.3 | -3.0 | 3.0 | 2.9 | -2.9 | 2.9 | -2.9 | 3.6 | 3.0 | -3.0 | 2.8 | 2.9 | -3.0 | 1.4 | -2.9 | -3.1 | 2.9 | -2.9 | 3.0 | 3.0 | -3.1 | 3.3 | -3.0 | 3.0 |
Locomotion distance, session 3 | 5.0 | 5.4 | 6.1 | -2.4 | 2.1 | -2.1 | 2.3 | -2.2 | 2.4 | -2.4 | -2.4 | 2.4 | -2.4 | 2.4 | -2.1 | -2.4 | 2.4 | -2.5 | -2.3 | 2.4 | -2.2 | 2.4 | 2.2 | -2.1 | 2.3 | -2.2 | -2.4 | 2.4 | -2.3 | 2.4 | -2.4 |
Delay discounting water rate 6 sec | 4.8 | 6.9 | 8.5 | 2.7 | -2.8 | 2.8 | -2.5 | 2.5 | -2.7 | 2.7 | 2.6 | -2.6 | 2.6 | -2.6 | 2.6 | 2.6 | -2.6 | 2.6 | 2.7 | -2.7 | 2.6 | -2.6 | -2.7 | 2.8 | -2.3 | 2.9 | 2.7 | -2.7 | 2.5 | -2.6 | 2.4 |
Delay discounting water rate 0 sec | 4.7 | 7.5 | 9.0 | 2.7 | -2.8 | 2.8 | -2.7 | 2.5 | -2.7 | 2.7 | 2.7 | -2.7 | 2.7 | -2.7 | 2.6 | 2.7 | -2.7 | 2.7 | 2.8 | -2.8 | 2.8 | -2.8 | -2.8 | 3.0 | -2.6 | 2.9 | 2.8 | -2.7 | 2.4 | -2.7 | 2.6 |
Bone: elastic displacement | 4.7 | 5.3 | 6.1 | -2.4 | 2.1 | -2.1 | 2.0 | -2.3 | 2.4 | -2.4 | -2.4 | 2.3 | -2.4 | 2.4 | -2.4 | -2.4 | 2.3 | -2.4 | -2.4 | 2.4 | -1.9 | 2.4 | 2.2 | -2.2 | 2.0 | -2.0 | -2.4 | 2.4 | -2.4 | 2.4 | -2.5 |
Bone: maximum diameter | 4.7 | 8.5 | 9.6 | 3.0 | -2.6 | 2.6 | -2.8 | 3.0 | -3.0 | 3.0 | 3.0 | -3.0 | 3.0 | -3.0 | 2.8 | 3.0 | -2.9 | 3.1 | 2.9 | -3.1 | 2.8 | -3.0 | -2.9 | 2.7 | -2.8 | 2.7 | 3.0 | -3.0 | 2.9 | -3.0 | 3.1 |
BMI with tail | 4.6 | 15.0 | 17.1 | 4.0 | -3.6 | 3.6 | -3.4 | 4.0 | -4.0 | 4.0 | 4.1 | -4.0 | 4.1 | -4.1 | 4.0 | 4.0 | -4.0 | 3.9 | 3.9 | -4.0 | 2.6 | -4.0 | -3.8 | 3.7 | -3.1 | 3.7 | 4.0 | -4.0 | 4.1 | -4.0 | 4.1 |
Post-drug Anxiety | 4.6 | 5.0 | 6.8 | 2.2 | -2.6 | 2.6 | -2.1 | 2.2 | -2.2 | 2.2 | 2.1 | -2.2 | 2.1 | -2.1 | 2.3 | 2.2 | -2.1 | 2.2 | 2.2 | -2.1 | 2.0 | -2.1 | -2.5 | 2.6 | -2.3 | 2.6 | 2.2 | -2.2 | 2.1 | -2.2 | 2.1 |
Bone: cortical thickness | 4.1 | 6.8 | 8.5 | 2.6 | -2.5 | 2.5 | -2.7 | 2.7 | -2.6 | 2.6 | 2.7 | -2.6 | 2.7 | -2.7 | 2.9 | 2.6 | -2.6 | 2.5 | 2.5 | -2.6 | 1.7 | -2.5 | -2.8 | 2.7 | -2.6 | 2.8 | 2.6 | -2.7 | 2.8 | -2.6 | 2.6 |
Bone: trabecular number | 3.9 | 6.1 | 10.4 | 2.4 | -2.2 | 2.2 | -2.2 | 2.9 | -2.5 | 2.5 | 2.4 | -2.4 | 2.4 | -2.4 | 3.2 | 2.5 | -2.6 | 2.3 | 2.4 | -2.5 | 0.7 | -2.5 | -2.6 | 2.4 | -2.2 | 2.4 | 2.5 | -2.6 | 2.9 | -2.6 | 2.5 |
Delay disc. indifference point, 8s delay | 3.9 | 4.0 | 5.1 | 2.0 | -2.2 | 2.2 | -2.0 | 1.8 | -2.0 | 2.0 | 2.0 | -1.9 | 2.0 | -2.0 | 2.3 | 2.0 | -2.0 | 1.9 | 2.1 | -2.0 | 1.3 | -2.0 | -2.1 | 2.0 | -2.1 | 2.0 | 2.0 | -2.1 | 1.9 | -2.0 | 2.0 |
Delay discounting water rate 12 sec | 3.8 | 5.8 | 6.4 | 2.4 | -2.4 | 2.4 | -2.3 | 2.4 | -2.4 | 2.4 | 2.5 | -2.4 | 2.5 | -2.5 | 2.4 | 2.4 | -2.2 | 2.4 | 2.3 | -2.4 | 2.2 | -2.4 | -2.4 | 2.5 | -2.1 | 2.5 | 2.4 | -2.4 | 2.4 | -2.4 | 2.4 |
Delta time in open arm before/after self-admin | 3.8 | 3.6 | 5.0 | -1.9 | 1.9 | -1.9 | 1.7 | -2.2 | 1.9 | -1.9 | -2.0 | 1.9 | -2.0 | 2.0 | -2.1 | -1.9 | 1.7 | -1.8 | -1.9 | 2.0 | -1.2 | 1.9 | 2.0 | -2.0 | 1.4 | -2.0 | -1.9 | 1.9 | -2.1 | 1.9 | -2.0 |
Ambulatory time before self-admin | 3.8 | 3.9 | 5.1 | -1.9 | 1.9 | -1.9 | 2.2 | -2.0 | 2.0 | -2.0 | -2.1 | 1.9 | -2.1 | 2.1 | -2.2 | -2.0 | 2.0 | -1.9 | -2.0 | 2.0 | -1.4 | 2.0 | 2.1 | -1.9 | 1.7 | -2.0 | -2.0 | 2.0 | -2.0 | 2.0 | -2.0 |
Delay discounting water rate 24 sec | 3.7 | 5.2 | 8.2 | 2.2 | -2.7 | 2.7 | -2.4 | 2.0 | -2.2 | 2.2 | 2.1 | -2.2 | 2.1 | -2.1 | 2.1 | 2.2 | -2.1 | 2.2 | 2.2 | -2.2 | 2.2 | -2.2 | -2.5 | 2.9 | -2.3 | 2.8 | 2.2 | -2.2 | 1.9 | -2.2 | 2.0 |
Reaction time premature initiation rate | 3.5 | 4.7 | 7.1 | -2.2 | 2.0 | -2.0 | 1.3 | -2.4 | 2.3 | -2.3 | -2.3 | 2.2 | -2.3 | 2.3 | -2.4 | -2.3 | 2.3 | -2.2 | -2.0 | 2.6 | -1.2 | 2.2 | 2.1 | -1.9 | 1.4 | -1.5 | -2.2 | 2.2 | -2.7 | 2.3 | -2.3 |
Total resting periods, locomotor time 2 | 3.5 | 3.8 | 4.9 | 2.0 | -1.9 | 1.9 | -1.9 | 1.9 | -2.0 | 2.0 | 1.8 | -2.0 | 1.8 | -1.8 | 1.6 | 2.0 | -2.0 | 2.1 | 2.0 | -2.0 | 2.2 | -2.0 | -1.8 | 1.8 | -2.1 | 1.8 | 2.0 | -1.9 | 1.8 | -2.0 | 2.0 |
Bouts of movement, locomotor time 2 | 3.4 | 3.6 | 4.6 | 2.0 | -1.9 | 1.9 | -2.0 | 1.8 | -1.9 | 1.9 | 1.8 | -2.0 | 1.8 | -1.8 | 1.6 | 1.9 | -2.0 | 2.0 | 1.9 | -1.9 | 2.2 | -2.0 | -1.8 | 1.8 | -2.1 | 1.8 | 1.9 | -1.9 | 1.7 | -1.9 | 2.0 |
Progressive ratio test 1 active lever presses | 3.3 | 3.4 | 4.1 | -1.8 | 1.7 | -1.7 | 1.6 | -1.6 | 1.9 | -1.9 | -2.0 | 1.8 | -2.0 | 2.0 | -2.0 | -1.9 | 1.9 | -1.8 | -1.9 | 2.0 | -1.8 | 2.0 | 1.8 | -1.6 | 1.4 | -1.7 | -1.9 | 1.9 | -1.8 | 1.9 | -2.0 |
Indifference point function ln k | 3.2 | 4.5 | 5.7 | 2.2 | -2.0 | 2.0 | -1.6 | 2.4 | -2.2 | 2.2 | 2.2 | -2.2 | 2.2 | -2.2 | 2.0 | 2.2 | -2.2 | 2.2 | 2.1 | -2.3 | 1.9 | -2.2 | -2.0 | 2.0 | -1.5 | 1.9 | 2.2 | -2.2 | 2.3 | -2.2 | 2.3 |
Indifference point function log k | 3.2 | 4.5 | 5.7 | 2.2 | -2.0 | 2.0 | -1.6 | 2.4 | -2.2 | 2.2 | 2.2 | -2.2 | 2.2 | -2.2 | 2.0 | 2.2 | -2.2 | 2.2 | 2.1 | -2.3 | 1.9 | -2.2 | -2.0 | 2.0 | -1.5 | 1.9 | 2.2 | -2.2 | 2.3 | -2.2 | 2.3 |
Intermitt. access day 1 inactive lever presses | 3.2 | 3.5 | 5.6 | -1.8 | 1.9 | -1.9 | 2.0 | -1.8 | 1.9 | -1.9 | -1.9 | 1.8 | -1.9 | 1.9 | -2.4 | -1.9 | 1.9 | -1.7 | -1.9 | 1.9 | -0.9 | 1.9 | 2.0 | -1.8 | 1.9 | -1.6 | -1.9 | 1.9 | -2.0 | 1.9 | -1.9 |
Delay discounting time to switch 0 sec | 3.1 | 4.7 | 5.4 | -2.2 | 1.9 | -1.9 | 2.2 | -2.1 | 2.2 | -2.2 | -2.3 | 2.2 | -2.3 | 2.3 | -2.2 | -2.2 | 2.2 | -2.2 | -2.3 | 2.3 | -2.1 | 2.3 | 2.1 | -2.0 | 2.1 | -1.8 | -2.2 | 2.2 | -2.1 | 2.2 | -2.3 |
Reaction time num false alarms AUC | 3.1 | 4.4 | 5.2 | -2.2 | 2.1 | -2.1 | 2.3 | -2.1 | 2.1 | -2.1 | -2.1 | 2.2 | -2.1 | 2.1 | -2.0 | -2.1 | 2.0 | -2.2 | -2.0 | 1.9 | -1.8 | 2.1 | 2.1 | -2.1 | 2.1 | -2.1 | -2.1 | 2.1 | -2.2 | 2.1 | -2.1 |
Locomotion velocity, session 3 | 3.1 | 3.6 | 4.3 | -2.0 | 1.8 | -1.8 | 2.0 | -1.8 | 1.9 | -1.9 | -1.8 | 2.0 | -1.8 | 1.8 | -1.9 | -1.9 | 1.9 | -2.0 | -1.7 | 1.8 | -1.5 | 1.8 | 1.9 | -2.0 | 2.0 | -2.0 | -1.9 | 1.9 | -2.1 | 1.9 | -1.8 |
Condit. Reinf. inactive responses | 3.1 | 3.7 | 5.4 | -1.8 | 2.0 | -2.0 | 2.3 | -1.8 | 1.8 | -1.8 | -1.8 | 1.8 | -1.8 | 1.8 | -2.2 | -1.8 | 1.8 | -1.8 | -1.9 | 1.8 | -1.4 | 1.9 | 2.2 | -2.2 | 2.3 | -2.1 | -1.8 | 1.9 | -1.8 | 1.9 | -1.8 |
Delay discounting total patch changes 18 sec | 3.0 | 4.0 | 6.0 | -2.0 | 2.0 | -2.0 | 1.7 | -1.8 | 2.0 | -2.0 | -2.1 | 1.9 | -2.1 | 2.1 | -2.4 | -2.0 | 2.1 | -1.9 | -2.0 | 2.2 | -1.0 | 2.0 | 2.0 | -1.9 | 1.9 | -1.9 | -2.0 | 2.1 | -2.3 | 2.0 | -2.1 |
Progressive ratio test 1 breakpoint | 3.0 | 3.1 | 3.9 | -1.7 | 1.7 | -1.7 | 1.6 | -1.5 | 1.8 | -1.8 | -1.9 | 1.7 | -1.9 | 1.9 | -2.0 | -1.8 | 1.8 | -1.7 | -1.8 | 1.9 | -1.7 | 1.9 | 1.8 | -1.7 | 1.4 | -1.8 | -1.8 | 1.8 | -1.7 | 1.8 | -1.9 |
Progressive ratio test 2 inactive lever presses | 3.0 | 3.4 | 5.3 | -1.8 | 1.9 | -1.9 | 2.3 | -1.5 | 1.8 | -1.8 | -1.8 | 1.8 | -1.8 | 1.8 | -2.2 | -1.8 | 1.8 | -1.7 | -1.8 | 1.8 | -1.3 | 1.8 | 2.0 | -1.8 | 2.2 | -2.1 | -1.8 | 1.9 | -1.8 | 1.8 | -1.8 |
Locomotion distance, session 1 | 2.9 | 3.7 | 5.2 | -2.0 | 2.0 | -2.0 | 1.6 | -1.9 | 1.9 | -1.9 | -1.8 | 2.0 | -1.8 | 1.8 | -1.8 | -2.0 | 1.9 | -2.0 | -1.8 | 1.9 | -1.8 | 1.9 | 1.9 | -2.3 | 1.7 | -2.3 | -1.9 | 1.9 | -2.0 | 2.0 | -1.9 |
Total heroin consumption | 2.8 | 3.4 | 4.8 | 1.9 | -2.0 | 2.0 | -2.2 | 1.8 | -1.8 | 1.8 | 1.7 | -1.9 | 1.7 | -1.7 | 1.4 | 1.8 | -1.6 | 1.9 | 1.7 | -1.6 | 2.0 | -1.9 | -2.0 | 2.0 | -2.1 | 2.0 | 1.8 | -1.8 | 1.6 | -1.8 | 1.9 |
Right kidney weight | 2.7 | 7.7 | 9.5 | 2.9 | -2.1 | 2.1 | -2.3 | 3.0 | -3.0 | 3.0 | 3.1 | -2.9 | 3.1 | -3.1 | 2.6 | 3.0 | -3.1 | 3.0 | 2.9 | -3.0 | 2.7 | -2.9 | -2.3 | 2.0 | -2.3 | 2.2 | 3.0 | -2.8 | 2.9 | -2.9 | 3.0 |
Locomotor testing distance | 2.7 | 4.4 | 5.3 | -2.1 | 2.3 | -2.3 | 2.2 | -1.9 | 2.1 | -2.1 | -2.0 | 2.1 | -2.0 | 2.0 | -2.2 | -2.1 | 2.2 | -2.1 | -2.2 | 2.0 | -1.6 | 2.2 | 2.2 | -2.1 | 2.1 | -2.1 | -2.1 | 2.2 | -1.9 | 2.1 | -2.1 |
Locomotor testing rearing | 2.7 | 4.2 | 6.1 | -1.9 | 2.4 | -2.4 | 2.3 | -1.5 | 2.0 | -2.0 | -2.0 | 1.9 | -2.0 | 2.0 | -2.3 | -1.9 | 1.9 | -1.8 | -2.2 | 2.0 | -1.4 | 2.2 | 2.3 | -2.2 | 2.1 | -2.5 | -2.0 | 2.1 | -1.8 | 2.0 | -2.0 |
Light reinforcement 1 | 2.7 | 4.9 | 6.9 | -2.1 | 2.1 | -2.1 | 2.0 | -1.8 | 2.3 | -2.3 | -2.4 | 2.1 | -2.4 | 2.4 | -2.6 | -2.2 | 2.4 | -2.0 | -2.4 | 2.4 | -1.6 | 2.3 | 2.1 | -2.1 | 2.1 | -2.1 | -2.3 | 2.3 | -2.2 | 2.2 | -2.4 |
Tibialis anterior weight | 2.6 | 9.1 | 15.0 | 3.0 | -2.9 | 2.9 | -2.7 | 2.9 | -3.1 | 3.1 | 3.1 | -3.1 | 3.1 | -3.1 | 2.3 | 3.0 | -3.2 | 3.2 | 3.3 | -3.1 | 3.9 | -3.2 | -2.7 | 2.9 | -2.7 | 2.9 | 3.1 | -2.9 | 2.4 | -3.0 | 3.1 |
Intermittent access terminal intake (last 3 days) | 2.6 | 2.8 | 3.2 | -1.7 | 1.7 | -1.7 | 1.7 | -1.5 | 1.7 | -1.7 | -1.8 | 1.7 | -1.8 | 1.8 | -1.6 | -1.6 | 1.5 | -1.7 | -1.6 | 1.7 | -1.7 | 1.8 | 1.7 | -1.6 | 1.8 | -1.8 | -1.6 | 1.6 | -1.6 | 1.6 | -1.8 |
Reaction time false alarm rate | 2.5 | 3.6 | 4.9 | -1.9 | 2.1 | -2.1 | 2.1 | -1.8 | 1.8 | -1.8 | -1.8 | 1.9 | -1.8 | 1.8 | -1.9 | -1.9 | 1.7 | -1.8 | -1.7 | 1.7 | -1.5 | 1.8 | 2.0 | -2.1 | 1.9 | -2.2 | -1.8 | 1.9 | -2.0 | 1.9 | -1.8 |
Intermittent access day 15 total infusions | 2.5 | 2.8 | 3.6 | -1.6 | 1.7 | -1.7 | 1.8 | -1.4 | 1.6 | -1.6 | -1.8 | 1.6 | -1.8 | 1.8 | -1.6 | -1.6 | 1.5 | -1.6 | -1.6 | 1.7 | -1.6 | 1.7 | 1.8 | -1.6 | 1.9 | -1.9 | -1.6 | 1.6 | -1.5 | 1.6 | -1.8 |
Progressive ratio test 1 inactive lever presses | 2.5 | 2.7 | 4.1 | -1.5 | 1.8 | -1.8 | 1.9 | -1.4 | 1.5 | -1.5 | -1.6 | 1.5 | -1.6 | 1.6 | -2.0 | -1.5 | 1.4 | -1.4 | -1.5 | 1.6 | -0.9 | 1.6 | 1.9 | -1.7 | 2.0 | -1.9 | -1.5 | 1.6 | -1.6 | 1.6 | -1.6 |
Bone: cortical porosity | 2.5 | 2.6 | 3.4 | -1.6 | 1.5 | -1.5 | 1.3 | -1.8 | 1.7 | -1.7 | -1.7 | 1.6 | -1.7 | 1.7 | -1.8 | -1.7 | 1.8 | -1.6 | -1.8 | 1.7 | -1.5 | 1.8 | 1.5 | -1.3 | 1.3 | -1.3 | -1.7 | 1.7 | -1.5 | 1.7 | -1.8 |
Latency to leave start box in cocaine runway, M | 2.5 | 2.4 | 3.0 | 1.5 | -1.7 | 1.7 | -1.6 | 1.3 | -1.5 | 1.5 | 1.5 | -1.5 | 1.5 | -1.5 | 1.6 | 1.5 | -1.6 | 1.4 | 1.6 | -1.7 | 1.3 | -1.5 | -1.6 | 1.7 | -1.6 | 1.6 | 1.5 | -1.5 | 1.4 | -1.5 | 1.5 |
Intermittent access total infusions | 2.4 | 2.7 | 3.1 | -1.6 | 1.5 | -1.5 | 1.4 | -1.5 | 1.6 | -1.6 | -1.8 | 1.6 | -1.8 | 1.8 | -1.5 | -1.6 | 1.6 | -1.7 | -1.6 | 1.7 | -1.7 | 1.8 | 1.7 | -1.4 | 1.5 | -1.7 | -1.6 | 1.6 | -1.5 | 1.6 | -1.8 |
Total locomotion distance, NPP test | 2.4 | 3.3 | 5.2 | -1.9 | 1.6 | -1.6 | 1.7 | -1.7 | 1.8 | -1.8 | -1.9 | 1.9 | -1.9 | 1.9 | -1.6 | -1.8 | 1.9 | -1.9 | -1.9 | 1.9 | -2.3 | 1.9 | 1.7 | -1.9 | 1.8 | -1.8 | -1.9 | 1.8 | -1.6 | 1.8 | -1.9 |
Delay discounting total patch changes 6 sec | 2.3 | 3.5 | 4.2 | -1.9 | 1.9 | -1.9 | 1.8 | -1.6 | 1.9 | -1.9 | -1.9 | 1.9 | -1.9 | 1.9 | -2.0 | -1.9 | 1.9 | -1.8 | -1.8 | 2.0 | -1.3 | 1.8 | 1.9 | -1.9 | 2.0 | -1.9 | -1.9 | 1.9 | -2.0 | 1.9 | -1.8 |
Progressive ratio test 2 breakpoint | 2.3 | 2.5 | 3.7 | -1.5 | 1.6 | -1.6 | 1.8 | -1.3 | 1.6 | -1.6 | -1.7 | 1.5 | -1.7 | 1.7 | -1.9 | -1.5 | 1.5 | -1.4 | -1.6 | 1.7 | -1.3 | 1.7 | 1.7 | -1.5 | 1.5 | -1.7 | -1.6 | 1.6 | -1.5 | 1.5 | -1.7 |
Weight adjusted by age | 2.3 | 2.6 | 3.4 | 1.8 | -1.3 | 1.3 | -1.3 | 1.8 | -1.7 | 1.7 | 1.8 | -1.8 | 1.8 | -1.8 | 1.1 | 1.8 | -1.8 | 1.9 | 1.5 | -1.7 | 1.6 | -1.6 | -1.3 | 1.2 | -1.1 | 1.1 | 1.7 | -1.6 | 1.8 | -1.7 | 1.7 |
Pavlov. Cond. intertrial magazine entries | 2.2 | 2.9 | 6.8 | -1.9 | 1.4 | -1.4 | 1.3 | -2.6 | 1.8 | -1.8 | -1.7 | 1.9 | -1.7 | 1.7 | -1.5 | -1.9 | 1.8 | -1.9 | -1.4 | 1.7 | -0.8 | 1.7 | 1.6 | -0.8 | 1.3 | -0.9 | -1.8 | 1.8 | -2.3 | 1.9 | -1.8 |
Intermittent access total locomotion | 2.2 | 2.5 | 4.1 | -1.5 | 1.5 | -1.5 | 0.9 | -1.4 | 1.7 | -1.7 | -1.8 | 1.5 | -1.8 | 1.8 | -2.0 | -1.6 | 1.6 | -1.4 | -1.7 | 1.7 | -1.0 | 1.8 | 1.5 | -1.4 | 1.1 | -1.4 | -1.6 | 1.6 | -1.7 | 1.6 | -1.8 |
Bone: cortical porosity | 2.2 | 2.3 | 3.1 | -1.5 | 1.6 | -1.6 | 1.4 | -1.5 | 1.6 | -1.6 | -1.5 | 1.4 | -1.5 | 1.5 | -1.8 | -1.5 | 1.6 | -1.5 | -1.7 | 1.6 | -1.5 | 1.7 | 1.5 | -1.4 | 1.4 | -1.4 | -1.6 | 1.5 | -1.3 | 1.5 | -1.7 |
Length with tail | 2.1 | 7.6 | 9.2 | 2.9 | -2.5 | 2.5 | -2.4 | 3.0 | -2.9 | 2.9 | 2.9 | -2.9 | 2.9 | -2.9 | 2.7 | 2.9 | -2.9 | 2.9 | 2.8 | -2.9 | 2.6 | -2.9 | -2.5 | 2.4 | -2.4 | 2.2 | 2.9 | -2.8 | 2.8 | -2.9 | 2.9 |
Liver weight, left | 2.1 | 3.4 | 5.9 | 1.8 | -1.8 | 1.8 | -2.4 | 2.0 | -1.7 | 1.7 | 1.7 | -1.8 | 1.7 | -1.7 | 2.1 | 1.8 | -1.7 | 1.7 | 1.7 | -1.7 | 1.1 | -1.7 | -2.0 | 1.9 | -2.4 | 2.0 | 1.7 | -1.8 | 1.9 | -1.8 | 1.7 |
Locomotion distance, session 2 | 2.1 | 3.0 | 3.6 | -1.8 | 1.5 | -1.5 | 1.5 | -1.8 | 1.8 | -1.8 | -1.7 | 1.9 | -1.7 | 1.7 | -1.6 | -1.8 | 1.8 | -1.9 | -1.6 | 1.7 | -1.6 | 1.7 | 1.7 | -1.8 | 1.6 | -1.8 | -1.8 | 1.8 | -1.9 | 1.8 | -1.7 |
Stereotopy head waving duration, day 7 | 2.0 | 2.4 | 4.3 | 1.5 | -1.8 | 1.8 | -1.8 | 0.9 | -1.5 | 1.5 | 1.4 | -1.5 | 1.4 | -1.4 | 1.3 | 1.5 | -1.5 | 1.6 | 1.6 | -1.4 | 2.1 | -1.5 | -1.6 | 1.9 | -1.8 | 1.8 | 1.5 | -1.5 | 1.1 | -1.5 | 1.4 |
Reaction time num false alarms | 1.9 | 2.6 | 3.4 | -1.6 | 1.6 | -1.6 | 1.8 | -1.7 | 1.6 | -1.6 | -1.6 | 1.7 | -1.6 | 1.6 | -1.7 | -1.6 | 1.6 | -1.6 | -1.5 | 1.4 | -1.1 | 1.6 | 1.7 | -1.6 | 1.7 | -1.7 | -1.6 | 1.6 | -1.8 | 1.7 | -1.6 |
Reaction time premature initiations | 1.9 | 2.8 | 4.3 | -1.8 | 1.3 | -1.3 | 0.8 | -1.9 | 1.8 | -1.8 | -1.9 | 1.8 | -1.9 | 1.9 | -1.8 | -1.8 | 1.9 | -1.8 | -1.6 | 2.0 | -0.9 | 1.7 | 1.5 | -1.2 | 0.9 | -0.8 | -1.8 | 1.7 | -2.1 | 1.8 | -1.9 |
Liver weight, right | 1.8 | 3.0 | 4.1 | 1.8 | -1.3 | 1.3 | -1.7 | 2.0 | -1.8 | 1.8 | 1.8 | -1.8 | 1.8 | -1.8 | 1.8 | 1.8 | -1.8 | 1.8 | 1.7 | -1.8 | 1.6 | -1.7 | -1.6 | 1.4 | -1.8 | 1.4 | 1.8 | -1.8 | 1.9 | -1.8 | 1.8 |
Lifetime Intake | 1.8 | 2.1 | 2.4 | -1.4 | 1.3 | -1.3 | 1.3 | -1.3 | 1.4 | -1.4 | -1.6 | 1.4 | -1.6 | 1.6 | -1.4 | -1.4 | 1.4 | -1.4 | -1.4 | 1.5 | -1.6 | 1.5 | 1.5 | -1.2 | 1.4 | -1.5 | -1.4 | 1.4 | -1.3 | 1.4 | -1.6 |
Progressive ratio test 2 active lever presses | 1.8 | 1.9 | 2.9 | -1.3 | 1.4 | -1.4 | 1.6 | -1.0 | 1.3 | -1.3 | -1.4 | 1.3 | -1.4 | 1.4 | -1.7 | -1.3 | 1.2 | -1.2 | -1.4 | 1.4 | -1.1 | 1.4 | 1.5 | -1.3 | 1.5 | -1.5 | -1.3 | 1.4 | -1.3 | 1.3 | -1.4 |
Latency to leave start box in cocaine runway, F | 1.8 | 2.0 | 2.9 | -1.4 | 1.5 | -1.5 | 1.5 | -1.3 | 1.4 | -1.4 | -1.4 | 1.3 | -1.4 | 1.4 | -1.7 | -1.4 | 1.4 | -1.3 | -1.4 | 1.5 | -0.9 | 1.4 | 1.4 | -1.4 | 1.5 | -1.3 | -1.4 | 1.5 | -1.4 | 1.4 | -1.4 |
Delay disc. indifference point, 16s delay | 1.7 | 1.7 | 2.0 | 1.4 | -1.3 | 1.3 | -1.3 | 1.3 | -1.4 | 1.4 | 1.3 | -1.4 | 1.3 | -1.3 | 1.2 | 1.4 | -1.4 | 1.4 | 1.3 | -1.3 | 1.0 | -1.3 | -1.3 | 1.3 | -1.4 | 1.0 | 1.4 | -1.4 | 1.2 | -1.4 | 1.3 |
Intermittent access day 1 total infusions | 1.5 | 1.7 | 1.9 | -1.3 | 1.4 | -1.4 | 1.2 | -1.3 | 1.3 | -1.3 | -1.3 | 1.3 | -1.3 | 1.3 | -1.2 | -1.3 | 1.2 | -1.3 | -1.3 | 1.2 | -1.4 | 1.3 | 1.4 | -1.2 | 1.2 | -1.4 | -1.3 | 1.3 | -1.2 | 1.3 | -1.3 |
Delay disc. indifference point, 0s delay | 1.5 | 1.7 | 2.0 | 1.4 | -1.3 | 1.3 | -0.7 | 1.2 | -1.4 | 1.4 | 1.4 | -1.4 | 1.4 | -1.4 | 1.1 | 1.4 | -1.3 | 1.4 | 1.3 | -1.4 | 1.2 | -1.3 | -1.2 | 1.2 | -1.0 | 1.3 | 1.4 | -1.3 | 1.3 | -1.4 | 1.4 |
Indifference point 0 sec | 1.4 | 2.3 | 3.3 | -1.6 | 1.6 | -1.6 | 1.5 | -1.3 | 1.6 | -1.6 | -1.5 | 1.5 | -1.5 | 1.5 | -1.8 | -1.6 | 1.5 | -1.5 | -1.4 | 1.4 | -0.9 | 1.5 | 1.6 | -1.4 | 1.7 | -1.5 | -1.5 | 1.6 | -1.8 | 1.6 | -1.5 |
Delay discounting total patch changes 0 sec | 1.4 | 2.2 | 3.2 | -1.5 | 1.4 | -1.4 | 1.4 | -1.3 | 1.5 | -1.5 | -1.5 | 1.5 | -1.5 | 1.5 | -1.8 | -1.5 | 1.5 | -1.5 | -1.4 | 1.4 | -0.8 | 1.5 | 1.5 | -1.2 | 1.6 | -1.4 | -1.5 | 1.5 | -1.8 | 1.5 | -1.5 |
Conditioned reinforcement - actives | 1.4 | 1.4 | 1.7 | -1.2 | 0.9 | -0.9 | 1.0 | -1.2 | 1.2 | -1.2 | -1.3 | 1.2 | -1.3 | 1.3 | -1.3 | -1.2 | 1.2 | -1.2 | -1.2 | 1.3 | -1.1 | 1.3 | 1.2 | -0.8 | 1.1 | -1.1 | -1.2 | 1.2 | -1.3 | 1.2 | -1.3 |
Area under the delay curve | 1.4 | 1.5 | 1.9 | 1.3 | -1.2 | 1.2 | -0.9 | 1.1 | -1.3 | 1.3 | 1.3 | -1.2 | 1.3 | -1.3 | 1.4 | 1.3 | -1.3 | 1.2 | 1.3 | -1.3 | 0.7 | -1.3 | -1.2 | 1.1 | -1.2 | 1.0 | 1.3 | -1.3 | 1.2 | -1.3 | 1.3 |
Delay disc. indifference point, 24s delay | 1.4 | 1.4 | 1.6 | 1.2 | -1.0 | 1.0 | -1.0 | 1.2 | -1.2 | 1.2 | 1.3 | -1.3 | 1.3 | -1.3 | 1.1 | 1.3 | -1.3 | 1.3 | 1.2 | -1.3 | 0.9 | -1.2 | -1.1 | 1.0 | -1.1 | 1.0 | 1.2 | -1.2 | 1.2 | -1.3 | 1.3 |
Cu content in liver | 1.4 | 1.7 | 2.0 | 1.3 | -1.3 | 1.3 | -1.4 | 1.3 | -1.3 | 1.3 | 1.4 | -1.3 | 1.4 | -1.4 | 1.3 | 1.3 | -1.3 | 1.3 | 1.4 | -1.3 | 1.3 | -1.4 | -1.2 | 1.3 | -1.4 | 1.3 | 1.3 | -1.3 | 1.1 | -1.3 | 1.3 |
K content in liver | 1.4 | 1.4 | 2.1 | 1.1 | -1.0 | 1.0 | -1.0 | 0.8 | -1.2 | 1.2 | 1.5 | -1.1 | 1.5 | -1.5 | 1.2 | 1.2 | -1.3 | 1.2 | 1.4 | -1.2 | 1.3 | -1.3 | -1.0 | 1.1 | -1.0 | 1.1 | 1.3 | -1.2 | 0.8 | -1.2 | 1.3 |
Cocaine induced anxiety | 1.3 | 1.5 | 2.7 | 1.2 | -1.5 | 1.5 | -1.2 | 1.3 | -1.2 | 1.2 | 1.1 | -1.2 | 1.1 | -1.1 | 1.1 | 1.1 | -1.2 | 1.2 | 1.2 | -1.0 | 1.3 | -1.1 | -1.4 | 1.5 | -1.2 | 1.7 | 1.2 | -1.2 | 1.0 | -1.2 | 1.1 |
Locomotion velocity, NPP test | 1.3 | 1.9 | 3.7 | -1.4 | 1.2 | -1.2 | 1.3 | -1.3 | 1.4 | -1.4 | -1.4 | 1.4 | -1.4 | 1.4 | -1.1 | -1.4 | 1.4 | -1.5 | -1.4 | 1.4 | -1.9 | 1.4 | 1.2 | -1.4 | 1.3 | -1.4 | -1.4 | 1.3 | -1.1 | 1.3 | -1.4 |
Soleus weight | 1.2 | 3.4 | 5.4 | 1.8 | -1.7 | 1.7 | -2.0 | 1.4 | -1.8 | 1.8 | 1.9 | -1.8 | 1.9 | -1.9 | 1.5 | 1.8 | -1.9 | 1.9 | 2.0 | -1.9 | 2.3 | -1.9 | -1.8 | 1.9 | -2.0 | 1.8 | 1.9 | -1.8 | 1.4 | -1.8 | 1.8 |
Food consumed during 24 hour testing period | 1.2 | 1.5 | 2.6 | 1.1 | -1.1 | 1.1 | -1.3 | 1.5 | -1.2 | 1.2 | 1.2 | -1.1 | 1.2 | -1.2 | 1.6 | 1.2 | -1.2 | 1.0 | 1.2 | -1.2 | 0.3 | -1.2 | -1.3 | 1.4 | -1.3 | 1.4 | 1.2 | -1.3 | 1.2 | -1.2 | 1.2 |
Locomotion distance, session 7 | 1.2 | 1.5 | 2.7 | -1.2 | 1.3 | -1.3 | 1.6 | -0.9 | 1.2 | -1.2 | -1.2 | 1.2 | -1.2 | 1.2 | -1.2 | -1.2 | 1.3 | -1.1 | -1.3 | 1.2 | -1.0 | 1.2 | 1.3 | -1.4 | 1.6 | -1.4 | -1.2 | 1.3 | -1.1 | 1.2 | -1.2 |
Stereotopy head waving bouts, day 7 | 1.2 | 1.3 | 2.3 | 1.2 | -1.3 | 1.3 | -1.2 | 0.8 | -1.1 | 1.1 | 1.1 | -1.2 | 1.1 | -1.1 | 0.9 | 1.1 | -1.1 | 1.2 | 1.1 | -1.1 | 1.5 | -1.1 | -1.2 | 1.4 | -1.2 | 1.3 | 1.1 | -1.1 | 0.9 | -1.1 | 1.1 |
Delay discount exponential model param | 1.2 | 1.2 | 1.5 | -1.1 | 1.1 | -1.1 | 0.8 | -1.0 | 1.2 | -1.2 | -1.2 | 1.1 | -1.2 | 1.2 | -1.2 | -1.2 | 1.2 | -1.1 | -1.2 | 1.2 | -0.6 | 1.2 | 1.0 | -0.9 | 1.1 | -0.8 | -1.2 | 1.2 | -1.1 | 1.2 | -1.2 |
Vertical activity count, locomotor time 1 | 1.2 | 1.3 | 1.8 | 1.0 | -1.3 | 1.3 | -1.2 | 1.1 | -1.1 | 1.1 | 1.1 | -1.0 | 1.1 | -1.1 | 1.4 | 1.1 | -1.0 | 0.9 | 1.1 | -1.1 | 0.7 | -1.0 | -1.2 | 1.3 | -1.1 | 1.2 | 1.1 | -1.1 | 1.1 | -1.1 | 1.0 |
Run reversals in cocaine runway, males | 1.2 | 1.1 | 1.5 | -1.1 | 1.1 | -1.1 | 1.1 | -1.1 | 1.0 | -1.0 | -1.0 | 1.1 | -1.0 | 1.0 | -1.2 | -1.1 | 1.1 | -1.0 | -1.0 | 1.2 | -0.4 | 1.0 | 1.1 | -1.1 | 1.1 | -1.0 | -1.0 | 1.1 | -1.2 | 1.1 | -1.0 |
Delay discounting total patch changes 12 sec | 1.1 | 1.5 | 2.5 | -1.2 | 1.1 | -1.1 | 0.6 | -1.3 | 1.3 | -1.3 | -1.3 | 1.2 | -1.3 | 1.3 | -1.5 | -1.3 | 1.2 | -1.2 | -1.1 | 1.4 | -0.5 | 1.1 | 1.1 | -1.0 | 0.9 | -0.9 | -1.2 | 1.3 | -1.6 | 1.3 | -1.2 |
Conditioned reinforcement - inactives | 1.1 | 1.2 | 1.8 | -1.1 | 1.0 | -1.0 | 1.0 | -1.3 | 1.1 | -1.1 | -1.2 | 1.2 | -1.2 | 1.2 | -1.0 | -1.1 | 1.0 | -1.1 | -1.0 | 1.2 | -1.0 | 1.1 | 1.1 | -1.0 | 1.1 | -0.9 | -1.1 | 1.1 | -1.2 | 1.1 | -1.2 |
Intermitt. access day 15 inactive lever presses | 1.1 | 1.2 | 2.2 | -1.0 | 1.4 | -1.4 | 1.4 | -1.0 | 1.0 | -1.0 | -1.0 | 0.9 | -1.0 | 1.0 | -1.4 | -1.0 | 0.9 | -0.9 | -1.0 | 1.0 | -0.6 | 1.0 | 1.2 | -1.3 | 1.5 | -1.0 | -1.0 | 1.1 | -1.0 | 1.0 | -1.0 |
Time to tail flick, vehicle, before self-admin | 1.1 | 1.1 | 1.7 | -1.1 | 0.9 | -0.9 | 0.8 | -1.1 | 1.1 | -1.1 | -1.1 | 1.1 | -1.1 | 1.1 | -1.1 | -1.1 | 1.2 | -1.2 | -1.0 | 1.2 | -1.0 | 1.0 | 1.0 | -0.8 | 0.5 | -1.0 | -1.1 | 1.1 | -1.3 | 1.2 | -1.0 |
Delay discount hyperbolic model param | 1.1 | 1.1 | 1.4 | -1.1 | 1.0 | -1.0 | 0.6 | -1.0 | 1.2 | -1.2 | -1.2 | 1.1 | -1.2 | 1.2 | -1.2 | -1.1 | 1.1 | -1.1 | -1.2 | 1.2 | -0.6 | 1.2 | 0.9 | -0.9 | 1.0 | -0.7 | -1.2 | 1.1 | -1.0 | 1.1 | -1.2 |
Delay discounting total patch changes 24 sec | 1.0 | 1.3 | 2.4 | -1.1 | 1.3 | -1.3 | 0.8 | -1.0 | 1.2 | -1.2 | -1.2 | 1.1 | -1.2 | 1.2 | -1.5 | -1.1 | 1.2 | -1.0 | -1.1 | 1.2 | -0.1 | 1.1 | 1.2 | -1.1 | 1.1 | -1.0 | -1.1 | 1.2 | -1.4 | 1.2 | -1.2 |
Light reinforcement 2 | 1.0 | 1.3 | 1.8 | -1.1 | 1.1 | -1.1 | 1.2 | -1.0 | 1.1 | -1.1 | -1.2 | 1.0 | -1.2 | 1.2 | -1.2 | -1.1 | 1.1 | -1.0 | -1.2 | 1.2 | -1.3 | 1.1 | 1.2 | -1.2 | 1.3 | -1.2 | -1.1 | 1.1 | -1.0 | 1.1 | -1.2 |
Social time | 1.0 | 1.4 | 4.6 | -1.0 | 1.5 | -1.5 | 1.6 | -0.5 | 1.0 | -1.0 | -0.9 | 1.0 | -0.9 | 0.9 | -0.7 | -0.9 | 0.9 | -1.1 | -1.4 | 1.0 | -2.1 | 1.1 | 1.2 | -1.6 | 1.4 | -1.6 | -1.1 | 1.0 | -0.4 | 0.9 | -0.8 |
Pavlov. Cond. magazine entry number | 1.0 | 1.3 | 2.7 | -1.3 | 0.9 | -0.9 | 0.9 | -1.6 | 1.2 | -1.2 | -1.1 | 1.3 | -1.1 | 1.1 | -1.1 | -1.3 | 1.1 | -1.3 | -0.9 | 1.1 | -0.5 | 1.1 | 1.1 | -0.7 | 0.9 | -0.7 | -1.2 | 1.2 | -1.6 | 1.3 | -1.2 |
Intermittent access day 1 locomotion | 1.0 | 1.0 | 1.7 | -0.9 | 1.0 | -1.0 | 0.8 | -0.8 | 1.0 | -1.0 | -1.1 | 0.9 | -1.1 | 1.1 | -1.3 | -1.0 | 1.0 | -0.9 | -1.1 | 1.0 | -0.7 | 1.1 | 1.0 | -0.9 | 0.9 | -1.1 | -1.0 | 1.0 | -0.9 | 1.0 | -1.1 |
Intermittent access day 15 total locomotion | 1.0 | 1.1 | 2.2 | -0.9 | 1.2 | -1.2 | 1.1 | -0.7 | 1.0 | -1.0 | -1.1 | 0.9 | -1.1 | 1.1 | -1.5 | -0.9 | 0.9 | -0.8 | -1.1 | 1.0 | -0.5 | 1.1 | 1.2 | -1.2 | 1.2 | -1.3 | -1.0 | 1.0 | -0.9 | 0.9 | -1.1 |
Novel to familiar place preference ratio | 1.0 | 1.1 | 3.7 | 1.1 | -0.7 | 0.7 | -0.8 | 1.9 | -1.0 | 1.0 | 1.0 | -1.2 | 1.0 | -1.0 | 0.9 | 1.1 | -0.9 | 1.2 | 0.7 | -1.0 | 0.9 | -0.9 | -1.0 | 0.9 | -0.8 | 0.8 | 1.0 | -1.0 | 1.3 | -1.1 | 1.0 |
Bone: trabecular spacing | 1.0 | 1.3 | 3.1 | -1.1 | 1.1 | -1.1 | 0.8 | -1.7 | 1.2 | -1.2 | -1.1 | 1.1 | -1.1 | 1.1 | -1.8 | -1.2 | 1.2 | -1.0 | -1.0 | 1.2 | 0.3 | 1.1 | 1.2 | -1.0 | 0.8 | -1.0 | -1.1 | 1.2 | -1.6 | 1.2 | -1.1 |
Distance traveled before self-admin | 1.0 | 1.1 | 1.8 | -1.0 | 1.0 | -1.0 | 1.2 | -1.0 | 1.0 | -1.0 | -1.1 | 1.0 | -1.1 | 1.1 | -1.3 | -1.0 | 1.0 | -0.9 | -1.1 | 1.0 | -0.6 | 1.1 | 1.1 | -1.0 | 0.7 | -1.1 | -1.0 | 1.1 | -1.0 | 1.0 | -1.0 |
Time to tail flick, test, before self-admin | 1.0 | 1.0 | 2.5 | -0.8 | 1.2 | -1.2 | 1.5 | -1.0 | 0.8 | -0.8 | -0.8 | 0.8 | -0.8 | 0.8 | -1.0 | -0.8 | 0.5 | -0.7 | -0.9 | 0.8 | -0.6 | 0.9 | 1.1 | -1.2 | 1.6 | -1.6 | -0.8 | 0.9 | -0.6 | 0.8 | -0.9 |
Ambulatory time after self-admin | 1.0 | 1.1 | 1.8 | -1.1 | 0.6 | -0.6 | 0.3 | -1.3 | 1.2 | -1.2 | -1.3 | 1.1 | -1.3 | 1.3 | -0.9 | -1.2 | 1.3 | -1.2 | -1.1 | 1.3 | -0.9 | 1.2 | 0.6 | -0.5 | 0.0 | -0.3 | -1.2 | 1.1 | -1.3 | 1.2 | -1.3 |
Std. dev. time between licks in bursts | 0.9 | 1.1 | 1.4 | -1.1 | 0.9 | -0.9 | 0.5 | -0.9 | 1.1 | -1.1 | -1.2 | 1.0 | -1.2 | 1.2 | -1.2 | -1.1 | 1.2 | -1.1 | -1.2 | 1.2 | -1.0 | 1.2 | 0.8 | -0.7 | 0.5 | -0.6 | -1.1 | 1.1 | -1.0 | 1.1 | -1.2 |
Delay discounting water rate 18 sec | 0.9 | 1.1 | 1.7 | 1.0 | -1.0 | 1.0 | -1.1 | 1.1 | -1.0 | 1.0 | 1.1 | -1.0 | 1.1 | -1.1 | 1.0 | 1.0 | -1.1 | 1.0 | 1.2 | -1.0 | 1.3 | -1.2 | -1.0 | 1.2 | -1.0 | 1.3 | 1.1 | -1.1 | 0.7 | -1.0 | 1.0 |
Locomotor activity | 0.9 | 1.4 | 1.9 | -1.2 | 1.3 | -1.3 | 1.4 | -0.9 | 1.2 | -1.2 | -1.1 | 1.1 | -1.1 | 1.1 | -1.3 | -1.2 | 1.1 | -1.1 | -1.3 | 1.2 | -0.8 | 1.2 | 1.2 | -1.2 | 1.3 | -1.2 | -1.2 | 1.2 | -1.1 | 1.2 | -1.1 |
Reaction time trials AUC | 0.9 | 1.3 | 2.7 | 1.1 | -1.5 | 1.5 | -1.2 | 0.8 | -1.0 | 1.0 | 1.0 | -1.0 | 1.0 | -1.0 | 1.3 | 1.0 | -0.8 | 1.0 | 1.0 | -1.0 | 0.9 | -1.0 | -1.3 | 1.6 | -1.2 | 1.6 | 1.0 | -1.1 | 1.1 | -1.1 | 0.9 |
Social response proportion | 0.9 | 1.0 | 3.1 | -0.8 | 1.2 | -1.2 | 1.6 | -0.6 | 0.8 | -0.8 | -0.6 | 0.8 | -0.6 | 0.6 | -0.9 | -0.8 | 0.8 | -0.8 | -1.0 | 1.0 | -0.9 | 0.9 | 1.1 | -1.4 | 1.8 | -1.5 | -0.8 | 0.9 | -0.6 | 0.8 | -0.7 |
Condit. Reinf. inactive responses | 0.9 | 1.1 | 1.5 | -1.0 | 1.0 | -1.0 | 1.0 | -0.9 | 1.1 | -1.1 | -1.1 | 1.0 | -1.1 | 1.1 | -1.2 | -1.0 | 1.1 | -1.0 | -1.1 | 1.2 | -0.7 | 1.1 | 1.1 | -0.8 | 1.0 | -0.9 | -1.1 | 1.1 | -1.0 | 1.0 | -1.1 |
Intermittent access intake day 1-15 change | 0.9 | 0.9 | 1.4 | -1.0 | 0.7 | -0.7 | 0.8 | -0.9 | 1.0 | -1.0 | -1.1 | 1.0 | -1.1 | 1.1 | -0.7 | -1.0 | 0.9 | -1.1 | -0.9 | 1.0 | -1.2 | 1.0 | 0.8 | -0.7 | 0.9 | -1.0 | -1.0 | 0.9 | -1.0 | 1.0 | -1.1 |
Intermittent access intake escalation 2 | 0.9 | 0.9 | 1.2 | -1.0 | 0.8 | -0.8 | 0.8 | -0.9 | 0.9 | -0.9 | -1.1 | 1.0 | -1.1 | 1.1 | -0.7 | -1.0 | 0.8 | -1.0 | -0.8 | 1.1 | -1.0 | 1.0 | 0.9 | -0.8 | 0.8 | -0.9 | -0.9 | 0.9 | -1.0 | 0.9 | -1.1 |
Baseline Anxiety | 0.9 | 1.0 | 1.5 | 1.0 | -0.8 | 0.8 | -0.8 | 0.9 | -1.0 | 1.0 | 1.1 | -1.0 | 1.1 | -1.1 | 1.1 | 1.1 | -1.0 | 1.0 | 0.9 | -1.2 | 0.5 | -1.0 | -0.9 | 0.8 | -1.0 | 0.5 | 1.0 | -1.1 | 1.2 | -1.1 | 1.1 |
Total zone transitions, NPP test | 0.9 | 1.3 | 2.1 | -1.2 | 1.0 | -1.0 | 0.8 | -1.5 | 1.2 | -1.2 | -1.1 | 1.2 | -1.1 | 1.1 | -0.9 | -1.2 | 1.2 | -1.3 | -1.1 | 1.2 | -1.4 | 1.1 | 1.0 | -1.2 | 0.8 | -1.2 | -1.2 | 1.1 | -1.1 | 1.2 | -1.2 |
Diff in mean of infusions in LGA sessions | 0.9 | 1.0 | 1.5 | 1.0 | -0.7 | 0.7 | -1.0 | 1.1 | -1.1 | 1.1 | 1.1 | -1.0 | 1.1 | -1.1 | 1.1 | 1.1 | -1.2 | 1.0 | 1.0 | -1.0 | 0.7 | -1.1 | -1.0 | 0.9 | -0.6 | 1.0 | 1.1 | -1.1 | 1.1 | -1.1 | 1.2 |
Time in closed arm before self-admin | 0.9 | 1.1 | 2.2 | 1.1 | -0.9 | 0.9 | -0.8 | 1.3 | -1.1 | 1.1 | 1.0 | -1.2 | 1.0 | -1.0 | 0.5 | 1.1 | -1.2 | 1.2 | 1.0 | -1.1 | 1.5 | -1.0 | -0.9 | 1.0 | -0.6 | 0.9 | 1.1 | -1.0 | 0.9 | -1.1 | 1.0 |
Time in open arm before self-admin | 0.9 | 1.0 | 1.8 | 1.0 | -0.6 | 0.6 | -0.6 | 1.3 | -1.0 | 1.0 | 1.1 | -1.0 | 1.1 | -1.1 | 1.0 | 1.1 | -1.0 | 1.1 | 0.9 | -1.1 | 0.8 | -1.1 | -0.8 | 0.7 | -0.6 | 0.8 | 1.0 | -1.0 | 1.2 | -1.1 | 1.2 |
Sr content in liver | 0.9 | 0.9 | 1.0 | 0.9 | -1.0 | 1.0 | -1.0 | 0.9 | -0.9 | 0.9 | 0.9 | -1.0 | 0.9 | -0.9 | 0.8 | 0.9 | -0.9 | 0.9 | 0.9 | -0.9 | 0.6 | -0.9 | -1.0 | 1.0 | -1.0 | 1.0 | 0.9 | -0.9 | 1.0 | -0.9 | 0.9 |
Parametrial fat weight | 0.8 | 1.6 | 4.3 | -1.4 | 0.5 | -0.5 | 0.6 | -2.1 | 1.4 | -1.4 | -1.3 | 1.5 | -1.3 | 1.3 | -1.2 | -1.5 | 1.5 | -1.5 | -1.0 | 1.4 | -1.2 | 1.3 | 0.9 | -0.4 | 0.6 | -0.5 | -1.3 | 1.3 | -1.8 | 1.4 | -1.4 |
Reaction time mean | 0.8 | 1.1 | 3.2 | -1.0 | 1.0 | -1.0 | 0.5 | -0.9 | 1.0 | -1.0 | -1.2 | 1.0 | -1.2 | 1.2 | -0.6 | -1.0 | 0.9 | -1.1 | -1.2 | 1.2 | -1.8 | 1.1 | 0.8 | -1.0 | 0.2 | -1.0 | -1.1 | 0.9 | -0.6 | 1.0 | -1.1 |
Cocaine response after cond. not corrected | 0.8 | 0.9 | 1.5 | -1.0 | 1.0 | -1.0 | 0.8 | -1.1 | 0.9 | -0.9 | -0.9 | 1.0 | -0.9 | 0.9 | -0.4 | -0.9 | 0.8 | -1.1 | -0.8 | 1.0 | -1.2 | 0.8 | 1.0 | -1.1 | 0.8 | -0.9 | -0.9 | 0.9 | -0.9 | 0.9 | -0.8 |
Stereotopy head waving bouts, day 3 | 0.8 | 1.0 | 1.4 | 1.0 | -1.0 | 1.0 | -1.2 | 0.8 | -1.0 | 1.0 | 1.0 | -1.1 | 1.0 | -1.0 | 0.8 | 1.0 | -0.9 | 1.1 | 0.9 | -1.0 | 0.9 | -1.0 | -1.0 | 1.0 | -1.1 | 1.0 | 1.0 | -1.0 | 1.1 | -1.0 | 1.0 |
Degree of sensitization stereotypy | 0.8 | 0.9 | 2.9 | 0.9 | -1.2 | 1.2 | -1.1 | 0.3 | -0.8 | 0.8 | 0.8 | -0.9 | 0.8 | -0.8 | 0.6 | 0.8 | -0.8 | 0.9 | 1.0 | -0.8 | 1.7 | -0.9 | -1.0 | 1.2 | -1.1 | 1.3 | 0.9 | -0.8 | 0.4 | -0.8 | 0.8 |
Delay disc. indifference point, 2s delay | 0.8 | 0.9 | 1.2 | 1.0 | -1.0 | 1.0 | -0.1 | 1.0 | -1.1 | 1.1 | 1.1 | -1.0 | 1.1 | -1.1 | 0.8 | 1.1 | -1.0 | 1.1 | 1.0 | -1.1 | 0.8 | -1.0 | -0.7 | 0.8 | -0.5 | 0.3 | 1.0 | -1.0 | 1.0 | -1.0 | 1.1 |
Time >=10cm from walls, locomotor time 1 | 0.8 | 0.8 | 1.5 | 0.8 | -1.2 | 1.2 | -1.1 | 0.8 | -0.8 | 0.8 | 0.8 | -0.7 | 0.8 | -0.8 | 1.2 | 0.8 | -0.8 | 0.6 | 0.9 | -0.8 | 0.2 | -0.8 | -0.9 | 1.1 | -1.2 | 1.0 | 0.8 | -0.9 | 0.8 | -0.8 | 0.7 |
Epididymis fat weight | 0.7 | 1.6 | 2.5 | 1.2 | -1.5 | 1.5 | -1.4 | 0.9 | -1.2 | 1.2 | 1.2 | -1.2 | 1.2 | -1.2 | 1.3 | 1.2 | -1.2 | 1.1 | 1.4 | -1.1 | 0.8 | -1.3 | -1.5 | 1.6 | -1.5 | 1.6 | 1.2 | -1.3 | 1.0 | -1.2 | 1.3 |
Pavlov. Cond. change in total contacts | 0.7 | 1.0 | 2.2 | 1.1 | -1.0 | 1.0 | -1.0 | 1.5 | -1.0 | 1.0 | 0.8 | -1.1 | 0.8 | -0.8 | 1.3 | 1.1 | -0.9 | 1.0 | 0.8 | -0.8 | -0.2 | -0.9 | -1.1 | 0.9 | -1.0 | 0.8 | 1.0 | -1.1 | 1.5 | -1.1 | 1.0 |
Short access day 1 total inactive lever presses | 0.7 | 0.7 | 1.1 | -0.9 | 0.6 | -0.6 | 0.7 | -0.9 | 0.9 | -0.9 | -1.0 | 0.9 | -1.0 | 1.0 | -0.8 | -0.9 | 0.9 | -0.9 | -0.8 | 1.1 | -0.8 | 1.0 | 0.7 | -0.6 | 0.7 | -0.4 | -0.9 | 0.9 | -0.9 | 0.9 | -1.0 |
Locomotion velocity, session 1 | 0.7 | 0.7 | 1.6 | -0.7 | 0.8 | -0.8 | 1.2 | -0.9 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 | 0.7 | -1.3 | -0.7 | 0.6 | -0.6 | -0.6 | 0.7 | 0.2 | 0.7 | 1.1 | -1.2 | 1.2 | -1.2 | -0.7 | 0.8 | -1.1 | 0.8 | -0.7 |
Locomotion distance, session 8 | 0.7 | 1.1 | 1.9 | -1.2 | 0.8 | -0.8 | 0.6 | -1.2 | 1.2 | -1.2 | -1.1 | 1.2 | -1.1 | 1.1 | -0.8 | -1.2 | 1.2 | -1.3 | -0.9 | 1.1 | -1.0 | 1.1 | 0.9 | -0.8 | 0.7 | -0.8 | -1.1 | 1.1 | -1.4 | 1.2 | -1.1 |
Degree of sensitization distance | 0.7 | 0.7 | 1.0 | 0.9 | -0.7 | 0.7 | -0.5 | 0.9 | -0.9 | 0.9 | 1.0 | -1.0 | 1.0 | -1.0 | 0.7 | 1.0 | -0.9 | 1.0 | 0.9 | -1.0 | 1.0 | -0.9 | -0.6 | 0.6 | -0.5 | 0.6 | 0.9 | -0.9 | 0.9 | -0.9 | 1.0 |
Condit. Reinf. active responses | 0.7 | 0.9 | 1.8 | -0.9 | 0.9 | -0.9 | 1.3 | -1.1 | 0.8 | -0.8 | -0.8 | 0.9 | -0.8 | 0.8 | -0.8 | -0.9 | 0.8 | -0.9 | -0.8 | 0.8 | -1.0 | 0.8 | 1.1 | -1.0 | 1.3 | -1.0 | -0.9 | 0.9 | -0.8 | 0.9 | -0.8 |
Fecal boli incidents, locomotor time 1 | 0.7 | 0.7 | 2.8 | -1.0 | 0.3 | -0.3 | 0.3 | -1.3 | 0.9 | -0.9 | -0.9 | 1.1 | -0.9 | 0.9 | 0.0 | -1.0 | 0.9 | -1.2 | -0.6 | 0.9 | -1.7 | 0.8 | 0.4 | -0.1 | 0.3 | -0.1 | -0.9 | 0.7 | -1.0 | 0.9 | -0.8 |
Locomotion in novel chamber | 0.7 | 0.9 | 2.5 | 1.0 | -0.6 | 0.6 | -0.5 | 0.8 | -1.0 | 1.0 | 1.1 | -1.0 | 1.1 | -1.1 | 0.5 | 1.0 | -1.3 | 1.1 | 1.0 | -1.0 | 1.6 | -0.9 | -0.6 | 0.6 | -0.3 | 0.2 | 1.0 | -0.9 | 0.9 | -1.0 | 1.0 |
Locomotion in novel chamber post-restriction | 0.7 | 0.8 | 1.4 | 0.9 | -1.1 | 1.1 | -0.7 | 0.6 | -0.9 | 0.9 | 0.9 | -0.9 | 0.9 | -0.9 | 0.7 | 0.8 | -1.0 | 0.9 | 1.0 | -0.9 | 1.2 | -0.8 | -0.9 | 1.2 | -0.8 | 1.0 | 0.9 | -0.9 | 0.6 | -0.8 | 0.8 |
Reaction time number correct | 0.6 | 0.9 | 2.1 | 0.9 | -1.4 | 1.4 | -1.0 | 0.7 | -0.8 | 0.8 | 0.8 | -0.8 | 0.8 | -0.8 | 1.2 | 0.8 | -0.6 | 0.8 | 0.8 | -0.8 | 0.7 | -0.8 | -1.2 | 1.4 | -1.0 | 1.5 | 0.8 | -0.9 | 1.0 | -0.9 | 0.7 |
Reaction time trials correct on left | 0.6 | 0.9 | 2.1 | 0.9 | -1.4 | 1.4 | -1.0 | 0.7 | -0.8 | 0.8 | 0.8 | -0.8 | 0.8 | -0.8 | 1.2 | 0.8 | -0.6 | 0.8 | 0.8 | -0.8 | 0.7 | -0.8 | -1.2 | 1.4 | -1.0 | 1.5 | 0.8 | -0.9 | 1.0 | -0.9 | 0.7 |
Intermittent access intake escalation | 0.6 | 0.6 | 1.0 | -0.8 | 0.5 | -0.5 | 0.7 | -0.7 | 0.8 | -0.8 | -0.9 | 0.8 | -0.9 | 0.9 | -0.5 | -0.8 | 0.7 | -0.9 | -0.6 | 0.8 | -1.0 | 0.8 | 0.7 | -0.6 | 0.8 | -0.8 | -0.7 | 0.7 | -0.8 | 0.8 | -0.9 |
Intermittent access standard deviation | 0.6 | 0.7 | 1.0 | -0.8 | 1.0 | -1.0 | 0.6 | -0.7 | 0.8 | -0.8 | -0.9 | 0.8 | -0.9 | 0.9 | -0.7 | -0.8 | 0.7 | -0.8 | -0.8 | 0.7 | -0.9 | 0.9 | 1.0 | -0.9 | 0.6 | -1.0 | -0.8 | 0.8 | -0.7 | 0.8 | -0.9 |
Short access day 10 total infusions | 0.6 | 0.6 | 1.0 | -0.8 | 0.7 | -0.7 | 0.8 | -0.7 | 0.8 | -0.8 | -0.9 | 0.8 | -0.9 | 0.9 | -0.6 | -0.8 | 0.7 | -0.8 | -0.8 | 0.8 | -1.0 | 0.9 | 0.9 | -0.6 | 1.0 | -0.8 | -0.8 | 0.8 | -0.8 | 0.8 | -0.9 |
Novelty place preference | 0.6 | 0.6 | 2.8 | 0.9 | -0.5 | 0.5 | -0.5 | 1.7 | -0.8 | 0.8 | 0.7 | -0.9 | 0.7 | -0.7 | 0.7 | 0.9 | -0.7 | 0.9 | 0.4 | -0.7 | 0.6 | -0.6 | -0.8 | 0.6 | -0.5 | 0.6 | 0.7 | -0.8 | 1.1 | -0.8 | 0.7 |
Pavlov. Cond. intertrial magazine entries | 0.6 | 0.7 | 1.1 | -0.8 | 1.0 | -1.0 | 1.1 | -0.9 | 0.7 | -0.7 | -0.9 | 0.8 | -0.9 | 0.9 | -0.8 | -0.8 | 0.7 | -0.8 | -0.7 | 0.7 | -0.9 | 0.7 | 1.0 | -0.8 | 1.0 | -0.9 | -0.8 | 0.8 | -0.7 | 0.8 | -0.7 |
Bone: cortical tissue density | 0.6 | 0.8 | 1.0 | -0.9 | 0.8 | -0.8 | 0.7 | -0.8 | 0.9 | -0.9 | -1.0 | 0.8 | -1.0 | 1.0 | -1.0 | -0.9 | 0.9 | -0.8 | -1.0 | 1.0 | -0.6 | 0.9 | 0.9 | -0.7 | 0.7 | -0.8 | -0.9 | 0.9 | -0.8 | 0.9 | -0.9 |
Change in fecal boli incidents, locomotor task | 0.6 | 0.6 | 1.0 | 0.8 | -0.1 | 0.1 | 0.1 | 0.8 | -0.8 | 0.8 | 1.0 | -0.9 | 1.0 | -1.0 | 0.2 | 0.9 | -1.0 | 1.0 | 0.7 | -0.9 | 1.0 | -0.8 | -0.3 | 0.1 | 0.1 | 0.1 | 0.8 | -0.7 | 0.9 | -0.8 | 0.9 |
Reaction time mean AUC | 0.5 | 0.6 | 2.6 | -0.8 | 0.7 | -0.7 | 0.3 | -0.8 | 0.8 | -0.8 | -1.0 | 0.8 | -1.0 | 1.0 | -0.3 | -0.8 | 0.7 | -0.9 | -0.9 | 0.9 | -1.6 | 0.8 | 0.6 | -0.7 | -0.0 | -0.7 | -0.8 | 0.7 | -0.4 | 0.7 | -0.9 |
Condit. Reinf. lever reinforcers received | 0.5 | 0.7 | 1.0 | -0.8 | 0.9 | -0.9 | 0.9 | -0.6 | 0.8 | -0.8 | -0.9 | 0.8 | -0.9 | 0.9 | -1.0 | -0.8 | 0.8 | -0.8 | -0.8 | 1.0 | -0.4 | 0.8 | 0.9 | -0.9 | 0.9 | -0.7 | -0.8 | 0.8 | -0.9 | 0.8 | -0.8 |
Compulsive drug intake | 0.5 | 0.5 | 0.7 | 0.7 | -0.7 | 0.7 | -0.7 | 0.6 | -0.8 | 0.8 | 0.8 | -0.7 | 0.8 | -0.8 | 0.9 | 0.7 | -0.7 | 0.7 | 0.7 | -0.8 | 0.6 | -0.8 | -0.6 | 0.7 | -0.6 | 0.6 | 0.7 | -0.7 | 0.7 | -0.7 | 0.8 |
Context. condit. distance diff. score | 0.5 | 0.5 | 0.8 | 0.7 | -0.7 | 0.7 | -0.9 | 0.8 | -0.7 | 0.7 | 0.8 | -0.7 | 0.8 | -0.8 | 0.7 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.9 | -0.7 | -0.8 | 0.8 | -0.8 | 0.8 | 0.7 | -0.7 | 0.6 | -0.7 | 0.7 |
Pavlov. Cond. lever-magazine prob. diff. | 0.5 | 0.6 | 1.2 | 0.7 | -0.9 | 0.9 | -1.1 | 0.9 | -0.7 | 0.7 | 0.7 | -0.7 | 0.7 | -0.7 | 1.1 | 0.7 | -0.6 | 0.6 | 0.6 | -0.6 | 0.1 | -0.6 | -0.9 | 0.8 | -1.1 | 0.8 | 0.7 | -0.8 | 0.9 | -0.7 | 0.6 |
Bone: trabecular thickness | 0.5 | 0.6 | 2.9 | -0.7 | 0.9 | -0.9 | 1.0 | -0.0 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 | 0.7 | -0.2 | -0.6 | 0.7 | -0.7 | -0.8 | 0.6 | -1.7 | 0.8 | 0.6 | -0.9 | 1.0 | -0.9 | -0.7 | 0.6 | -0.3 | 0.6 | -0.7 |
Extinction: sum of active levers before priming | 0.5 | 0.5 | 1.5 | 0.7 | -0.6 | 0.6 | -0.8 | 0.4 | -0.7 | 0.7 | 0.7 | -0.8 | 0.7 | -0.7 | 0.6 | 0.7 | -0.8 | 0.8 | 0.8 | -0.6 | 1.0 | -0.7 | -0.6 | 0.5 | -1.2 | 0.6 | 0.8 | -0.7 | 0.6 | -0.7 | 0.7 |
Delta time to tail flick, test, before/after SA | 0.5 | 0.4 | 0.8 | 0.6 | -0.7 | 0.7 | -0.4 | 0.8 | -0.6 | 0.6 | 0.7 | -0.6 | 0.7 | -0.7 | 0.6 | 0.6 | -0.6 | 0.6 | 0.7 | -0.7 | 0.8 | -0.7 | -0.7 | 0.8 | -0.7 | 0.9 | 0.6 | -0.6 | 0.5 | -0.6 | 0.7 |
Run reversals in cocaine runway, females | 0.5 | 0.5 | 1.8 | -0.5 | 1.0 | -1.0 | 1.3 | -0.3 | 0.5 | -0.5 | -0.4 | 0.5 | -0.4 | 0.4 | -0.7 | -0.5 | 0.7 | -0.4 | -0.7 | 0.5 | -0.6 | 0.5 | 0.7 | -0.9 | 1.3 | -0.9 | -0.6 | 0.6 | -0.3 | 0.5 | -0.4 |
Left kidney weight | 0.4 | 1.1 | 2.4 | 1.0 | -0.8 | 0.8 | -1.0 | 0.9 | -1.1 | 1.1 | 1.1 | -0.9 | 1.1 | -1.1 | 1.6 | 1.1 | -1.3 | 0.9 | 1.3 | -1.0 | 0.3 | -1.2 | -0.9 | 0.8 | -1.1 | 1.0 | 1.1 | -1.1 | 1.0 | -1.0 | 1.1 |
Mean time between licks in bursts | 0.4 | 0.6 | 1.2 | -0.8 | 0.5 | -0.5 | 0.7 | -0.9 | 0.8 | -0.8 | -0.9 | 0.8 | -0.9 | 0.9 | -0.7 | -0.8 | 0.9 | -0.8 | -0.9 | 0.9 | -1.1 | 0.9 | 0.7 | -0.5 | 0.7 | -0.6 | -0.8 | 0.8 | -0.6 | 0.8 | -0.9 |
Reaction time trials on left | 0.4 | 0.6 | 1.7 | 0.7 | -1.2 | 1.2 | -0.9 | 0.5 | -0.7 | 0.7 | 0.6 | -0.7 | 0.6 | -0.6 | 1.0 | 0.7 | -0.5 | 0.6 | 0.7 | -0.6 | 0.6 | -0.6 | -1.0 | 1.3 | -0.9 | 1.3 | 0.7 | -0.7 | 0.8 | -0.7 | 0.6 |
Reaction time trials completed | 0.4 | 0.6 | 1.7 | 0.7 | -1.2 | 1.2 | -0.9 | 0.5 | -0.7 | 0.7 | 0.6 | -0.7 | 0.6 | -0.6 | 1.0 | 0.7 | -0.5 | 0.6 | 0.7 | -0.6 | 0.6 | -0.6 | -1.0 | 1.3 | -0.9 | 1.3 | 0.7 | -0.7 | 0.8 | -0.7 | 0.6 |
Total sessions with >9 infusions | 0.4 | 0.4 | 0.9 | -0.6 | 0.7 | -0.7 | 0.5 | -0.4 | 0.6 | -0.6 | -0.7 | 0.6 | -0.7 | 0.7 | -0.6 | -0.6 | 0.6 | -0.6 | -0.7 | 0.6 | -0.9 | 0.7 | 0.8 | -0.7 | 0.6 | -1.0 | -0.6 | 0.6 | -0.4 | 0.6 | -0.7 |
Number of responses in last shaping day | 0.4 | 0.4 | 0.9 | 0.7 | -0.3 | 0.3 | -0.1 | 1.0 | -0.7 | 0.7 | 0.6 | -0.7 | 0.6 | -0.6 | 0.1 | 0.7 | -0.8 | 0.8 | 0.6 | -0.6 | 0.7 | -0.6 | -0.4 | 0.4 | -0.0 | 0.3 | 0.7 | -0.6 | 0.7 | -0.7 | 0.6 |
Time in novel zone, NPP test | 0.4 | 0.4 | 2.5 | 0.7 | -0.4 | 0.4 | -0.4 | 1.6 | -0.6 | 0.6 | 0.6 | -0.8 | 0.6 | -0.6 | 0.5 | 0.7 | -0.5 | 0.8 | 0.3 | -0.6 | 0.6 | -0.5 | -0.6 | 0.5 | -0.4 | 0.5 | 0.6 | -0.6 | 1.0 | -0.7 | 0.6 |
Bone: cortical apparent density | 0.4 | 0.6 | 0.8 | -0.7 | 0.7 | -0.7 | 0.6 | -0.7 | 0.8 | -0.8 | -0.9 | 0.7 | -0.9 | 0.9 | -0.8 | -0.8 | 0.8 | -0.7 | -0.9 | 0.9 | -0.6 | 0.8 | 0.7 | -0.6 | 0.6 | -0.6 | -0.8 | 0.8 | -0.7 | 0.8 | -0.8 |
Delay disc. indifference point, 4s delay | 0.4 | 0.4 | 0.7 | 0.6 | -0.5 | 0.5 | -0.2 | 0.6 | -0.7 | 0.7 | 0.7 | -0.6 | 0.7 | -0.7 | 0.8 | 0.6 | -0.7 | 0.6 | 0.8 | -0.7 | 0.1 | -0.7 | -0.5 | 0.4 | -0.4 | 0.5 | 0.7 | -0.6 | 0.6 | -0.6 | 0.7 |
Se content in liver | 0.4 | 0.5 | 1.0 | -0.7 | 0.8 | -0.8 | 1.0 | -0.5 | 0.6 | -0.6 | -0.5 | 0.7 | -0.5 | 0.5 | -0.6 | -0.6 | 0.5 | -0.6 | -0.5 | 0.6 | -0.7 | 0.6 | 0.9 | -0.8 | 1.0 | -1.0 | -0.6 | 0.7 | -0.7 | 0.6 | -0.5 |
Zn content in liver | 0.4 | 0.5 | 1.3 | -0.6 | 0.7 | -0.7 | 0.6 | -1.0 | 0.6 | -0.6 | -0.6 | 0.6 | -0.6 | 0.6 | -1.1 | -0.6 | 0.6 | -0.5 | -0.5 | 0.6 | 0.1 | 0.6 | 0.8 | -0.8 | 0.6 | -0.8 | -0.6 | 0.7 | -0.8 | 0.7 | -0.6 |
Number of licking bursts | 0.3 | 0.3 | 0.8 | -0.4 | 0.7 | -0.7 | 0.8 | 0.2 | 0.5 | -0.5 | -0.5 | 0.3 | -0.5 | 0.5 | -0.9 | -0.4 | 0.5 | -0.3 | -0.6 | 0.5 | -0.2 | 0.5 | 0.7 | -0.8 | 0.8 | -0.6 | -0.5 | 0.5 | -0.3 | 0.4 | -0.5 |
Condit. Reinf. active-inactive response ratio | 0.3 | 0.4 | 1.1 | -0.5 | 0.9 | -0.9 | 1.0 | -0.3 | 0.4 | -0.4 | -0.5 | 0.5 | -0.5 | 0.5 | -0.7 | -0.4 | 0.4 | -0.4 | -0.4 | 0.5 | -0.1 | 0.4 | 0.8 | -1.0 | 1.0 | -0.9 | -0.4 | 0.5 | -0.6 | 0.5 | -0.3 |
Pavlov. Cond. lever contacts | 0.3 | 0.3 | 1.5 | -0.5 | 0.3 | -0.3 | 0.3 | -0.2 | 0.6 | -0.6 | -0.8 | 0.6 | -0.8 | 0.8 | -0.3 | -0.6 | 0.7 | -0.7 | -0.7 | 0.8 | -1.2 | 0.7 | 0.4 | -0.5 | 0.3 | -0.4 | -0.6 | 0.5 | -0.3 | 0.5 | -0.7 |
Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.4 | 1.2 | 0.7 | -0.6 | 0.6 | -0.7 | 1.1 | -0.6 | 0.6 | 0.4 | -0.7 | 0.4 | -0.4 | 0.7 | 0.7 | -0.5 | 0.6 | 0.4 | -0.4 | -0.2 | -0.5 | -0.7 | 0.5 | -0.7 | 0.5 | 0.6 | -0.7 | 1.0 | -0.7 | 0.5 |
Intermitt. access escalation Index | 0.3 | 0.3 | 0.6 | -0.5 | 0.4 | -0.4 | 0.8 | -0.2 | 0.6 | -0.6 | -0.5 | 0.5 | -0.5 | 0.5 | -0.6 | -0.6 | 0.7 | -0.5 | -0.6 | 0.6 | -0.3 | 0.6 | 0.6 | -0.4 | 0.7 | -0.6 | -0.6 | 0.6 | -0.4 | 0.6 | -0.5 |
Short access day 10 total inactive lever presses | 0.3 | 0.3 | 0.9 | -0.5 | 0.4 | -0.4 | 0.6 | -0.6 | 0.6 | -0.6 | -0.7 | 0.5 | -0.7 | 0.7 | -0.9 | -0.6 | 0.5 | -0.4 | -0.5 | 0.7 | 0.4 | 0.6 | 0.5 | -0.4 | 0.5 | -0.2 | -0.5 | 0.6 | -0.8 | 0.6 | -0.7 |
One hour access (0.3 mA shock) | 0.3 | 0.3 | 1.0 | -0.5 | 0.8 | -0.8 | 0.8 | -0.2 | 0.4 | -0.4 | -0.5 | 0.5 | -0.5 | 0.5 | -0.6 | -0.4 | 0.3 | -0.4 | -0.4 | 0.5 | -0.5 | 0.5 | 0.8 | -0.7 | 1.0 | -1.0 | -0.4 | 0.5 | -0.5 | 0.4 | -0.5 |
Pavlov. Cond. lever contacts | 0.3 | 0.4 | 1.7 | -0.6 | 0.4 | -0.4 | 0.4 | -0.2 | 0.6 | -0.6 | -0.7 | 0.6 | -0.7 | 0.7 | -0.3 | -0.6 | 0.7 | -0.7 | -0.8 | 0.7 | -1.3 | 0.7 | 0.4 | -0.5 | 0.4 | -0.5 | -0.7 | 0.6 | -0.3 | 0.6 | -0.7 |
Bone: tissue strength | 0.3 | 0.3 | 1.1 | 0.6 | -0.6 | 0.6 | -0.6 | 1.1 | -0.6 | 0.6 | 0.4 | -0.6 | 0.4 | -0.4 | 0.6 | 0.6 | -0.6 | 0.6 | 0.4 | -0.4 | 0.1 | -0.5 | -0.7 | 0.5 | -0.6 | 0.6 | 0.5 | -0.6 | 0.7 | -0.6 | 0.5 |
Breakpoint value in progressive ratio session | 0.3 | 0.3 | 1.7 | 0.4 | -0.6 | 0.6 | -1.0 | 0.4 | -0.4 | 0.4 | 0.3 | -0.4 | 0.3 | -0.3 | 0.6 | 0.4 | -0.2 | 0.3 | 0.4 | -0.2 | 0.2 | -0.5 | -0.7 | 0.7 | -1.3 | 0.8 | 0.4 | -0.4 | 0.4 | -0.4 | 0.6 |
Active lever presses in extinction session 6 | 0.3 | 0.3 | 0.6 | 0.6 | -0.6 | 0.6 | -0.2 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.6 | 0.7 | -0.6 | 0.2 | -0.7 | -0.5 | 0.4 | -0.1 | 0.2 | 0.6 | -0.6 | 0.6 | -0.6 | 0.8 |
Delta distance traveled before/after self-admin | 0.3 | 0.4 | 1.4 | 0.3 | -0.9 | 0.9 | -1.2 | 0.2 | -0.4 | 0.4 | 0.3 | -0.3 | 0.3 | -0.3 | 1.0 | 0.3 | -0.3 | 0.2 | 0.5 | -0.4 | -0.2 | -0.4 | -0.9 | 0.9 | -0.8 | 1.1 | 0.4 | -0.5 | 0.3 | -0.4 | 0.3 |
Time in closed arm after self-admin | 0.3 | 0.3 | 0.8 | 0.6 | -0.1 | 0.1 | 0.3 | 0.9 | -0.6 | 0.6 | 0.6 | -0.6 | 0.6 | -0.6 | 0.3 | 0.6 | -0.6 | 0.6 | 0.5 | -0.6 | 0.3 | -0.6 | -0.3 | 0.3 | 0.4 | 0.3 | 0.6 | -0.5 | 0.6 | -0.6 | 0.7 |
Time in open arm after self-admin | 0.3 | 0.3 | 1.1 | -0.5 | 0.8 | -0.8 | 0.5 | -0.7 | 0.5 | -0.5 | -0.5 | 0.5 | -0.5 | 0.5 | -0.6 | -0.5 | 0.4 | -0.4 | -0.6 | 0.5 | -0.1 | 0.5 | 0.8 | -1.0 | 0.1 | -0.9 | -0.5 | 0.5 | -0.3 | 0.5 | -0.5 |
Distance moved, locomotor task time 2 | 0.3 | 0.3 | 0.5 | -0.6 | 0.4 | -0.4 | 0.2 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.6 | -0.6 | 0.7 | -0.5 | 0.7 | 0.4 | -0.5 | -0.2 | -0.3 | -0.6 | 0.6 | -0.7 | 0.6 | -0.7 |
Cd content in liver | 0.3 | 0.4 | 1.0 | -0.6 | 0.6 | -0.6 | 1.0 | -0.5 | 0.5 | -0.5 | -0.4 | 0.6 | -0.4 | 0.4 | -0.6 | -0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.4 | 0.5 | 0.7 | -0.8 | 1.0 | -0.8 | -0.5 | 0.6 | -0.6 | 0.6 | -0.5 |
Water consumed over 24 hours | 0.2 | 0.2 | 0.4 | 0.3 | -0.4 | 0.4 | -0.6 | 0.3 | -0.4 | 0.4 | 0.5 | -0.3 | 0.5 | -0.5 | 0.4 | 0.3 | -0.4 | 0.3 | 0.6 | -0.4 | 0.6 | -0.5 | -0.4 | 0.4 | -0.6 | 0.6 | 0.4 | -0.4 | 0.0 | -0.3 | 0.4 |
Condit. Reinf. active responses | 0.2 | 0.3 | 0.5 | -0.5 | 0.6 | -0.6 | 0.7 | -0.2 | 0.5 | -0.5 | -0.6 | 0.5 | -0.6 | 0.6 | -0.7 | -0.5 | 0.5 | -0.4 | -0.5 | 0.7 | -0.1 | 0.5 | 0.6 | -0.6 | 0.7 | -0.5 | -0.5 | 0.6 | -0.6 | 0.5 | -0.5 |
Pavlov. Cond. magazine entry latency | 0.2 | 0.3 | 1.0 | 0.6 | -0.2 | 0.2 | -0.4 | 1.0 | -0.6 | 0.6 | 0.4 | -0.6 | 0.4 | -0.4 | 0.6 | 0.6 | -0.5 | 0.6 | 0.3 | -0.5 | -0.1 | -0.5 | -0.5 | 0.1 | -0.4 | 0.2 | 0.5 | -0.6 | 0.9 | -0.6 | 0.5 |
Pavlov. Cond. latency score | 0.2 | 0.2 | 0.8 | 0.5 | -0.5 | 0.5 | -0.6 | 0.9 | -0.5 | 0.5 | 0.3 | -0.5 | 0.3 | -0.3 | 0.7 | 0.5 | -0.4 | 0.4 | 0.3 | -0.3 | -0.3 | -0.4 | -0.6 | 0.3 | -0.6 | 0.4 | 0.4 | -0.5 | 0.9 | -0.6 | 0.4 |
Conditioned locomotion | 0.2 | 0.3 | 0.5 | -0.5 | 0.2 | -0.2 | -0.1 | -0.4 | 0.6 | -0.6 | -0.7 | 0.5 | -0.7 | 0.7 | -0.7 | -0.5 | 0.6 | -0.5 | -0.5 | 0.6 | -0.4 | 0.6 | 0.4 | -0.1 | 0.2 | -0.2 | -0.5 | 0.5 | -0.6 | 0.5 | -0.7 |
Locomotion velocity, session 2 | 0.2 | 0.2 | 0.4 | -0.5 | 0.2 | -0.2 | 0.4 | -0.6 | 0.5 | -0.5 | -0.5 | 0.5 | -0.5 | 0.5 | -0.5 | -0.5 | 0.4 | -0.5 | -0.3 | 0.5 | -0.2 | 0.4 | 0.5 | -0.5 | 0.4 | -0.5 | -0.5 | 0.5 | -0.7 | 0.5 | -0.5 |
Stereotopy head waving duration, day 3 | 0.2 | 0.3 | 0.5 | 0.6 | -0.6 | 0.6 | -0.7 | 0.3 | -0.6 | 0.6 | 0.5 | -0.6 | 0.5 | -0.5 | 0.3 | 0.6 | -0.5 | 0.6 | 0.5 | -0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.6 | 0.5 | 0.5 | -0.6 | 0.6 | -0.6 | 0.5 |
Locomotion velocity, session 8 | 0.2 | 0.3 | 1.0 | 0.4 | -0.8 | 0.8 | -0.5 | 0.1 | -0.5 | 0.5 | 0.4 | -0.4 | 0.4 | -0.4 | 0.5 | 0.4 | -0.5 | 0.4 | 0.7 | -0.5 | 1.0 | -0.5 | -0.5 | 0.7 | -0.5 | 0.7 | 0.5 | -0.4 | 0.1 | -0.4 | 0.5 |
Condit. Reinf. lever presses | 0.2 | 0.2 | 0.6 | 0.5 | -0.5 | 0.5 | -0.4 | 0.6 | -0.5 | 0.5 | 0.5 | -0.5 | 0.5 | -0.5 | 0.7 | 0.5 | -0.5 | 0.4 | 0.4 | -0.4 | -0.2 | -0.4 | -0.6 | 0.4 | -0.4 | 0.4 | 0.5 | -0.5 | 0.8 | -0.5 | 0.4 |
Time in familiar zone, hab. session 1 | 0.2 | 0.2 | 0.5 | -0.5 | 0.6 | -0.6 | 0.4 | -0.7 | 0.4 | -0.4 | -0.4 | 0.5 | -0.4 | 0.4 | -0.4 | -0.5 | 0.3 | -0.5 | -0.2 | 0.4 | -0.3 | 0.3 | 0.6 | -0.6 | 0.4 | -0.6 | -0.4 | 0.4 | -0.6 | 0.5 | -0.4 |
Total zone transitions, hab. session 1 | 0.2 | 0.3 | 0.4 | -0.6 | 0.3 | -0.3 | 0.4 | -0.4 | 0.6 | -0.6 | -0.6 | 0.6 | -0.6 | 0.6 | -0.7 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.4 | 0.6 | 0.4 | -0.5 | 0.4 | -0.5 | -0.6 | 0.6 | -0.6 | 0.6 | -0.6 |
Total locomotion distance, hab. session 2 | 0.2 | 0.2 | 0.5 | -0.5 | 0.4 | -0.4 | 0.5 | -0.6 | 0.4 | -0.4 | -0.4 | 0.5 | -0.4 | 0.4 | -0.3 | -0.4 | 0.4 | -0.5 | -0.4 | 0.4 | -0.7 | 0.4 | 0.4 | -0.4 | 0.5 | -0.4 | -0.4 | 0.4 | -0.4 | 0.4 | -0.4 |
Bone: cortical thickness | 0.2 | 0.2 | 0.5 | 0.5 | -0.1 | 0.1 | -0.3 | 0.5 | -0.5 | 0.5 | 0.6 | -0.5 | 0.6 | -0.6 | 0.7 | 0.5 | -0.5 | 0.5 | 0.4 | -0.6 | 0.1 | -0.5 | -0.3 | 0.3 | -0.2 | 0.3 | 0.5 | -0.5 | 0.6 | -0.5 | 0.5 |
Distance traveled after self-admin | 0.2 | 0.2 | 0.8 | -0.3 | -0.4 | 0.4 | -0.7 | -0.4 | 0.3 | -0.3 | -0.5 | 0.3 | -0.5 | 0.5 | 0.2 | -0.3 | 0.4 | -0.4 | -0.1 | 0.3 | -0.5 | 0.2 | -0.3 | 0.4 | -0.9 | 0.6 | -0.3 | 0.1 | -0.4 | 0.3 | -0.3 |
Delta ambulatory time before/after self-admin | 0.2 | 0.3 | 1.1 | 0.3 | -0.9 | 0.9 | -1.0 | 0.2 | -0.3 | 0.3 | 0.2 | -0.2 | 0.2 | -0.2 | 0.8 | 0.2 | -0.2 | 0.1 | 0.4 | -0.2 | -0.2 | -0.3 | -0.8 | 0.9 | -0.6 | 1.1 | 0.3 | -0.4 | 0.2 | -0.3 | 0.2 |
Delta time to tail flick, vehicle, before/after SA | 0.2 | 0.2 | 0.6 | 0.5 | -0.1 | 0.1 | -0.5 | 0.7 | -0.5 | 0.5 | 0.5 | -0.6 | 0.5 | -0.5 | 0.5 | 0.5 | -0.4 | 0.6 | 0.3 | -0.7 | 0.3 | -0.4 | -0.4 | 0.2 | -0.4 | 0.3 | 0.5 | -0.5 | 0.8 | -0.5 | 0.5 |
Bouts of movement, locomotor time 1 | 0.2 | 0.3 | 0.8 | 0.4 | -0.4 | 0.4 | -0.9 | 0.2 | -0.4 | 0.4 | 0.3 | -0.4 | 0.3 | -0.3 | 0.9 | 0.4 | -0.6 | 0.3 | 0.5 | -0.5 | 0.0 | -0.5 | -0.6 | 0.6 | -0.9 | 0.7 | 0.4 | -0.5 | 0.6 | -0.5 | 0.5 |
Time >=10cm from walls, locomotor time 2 | 0.2 | 0.2 | 0.6 | -0.5 | 0.3 | -0.3 | 0.2 | -0.7 | 0.5 | -0.5 | -0.4 | 0.5 | -0.4 | 0.4 | -0.3 | -0.5 | 0.5 | -0.5 | -0.4 | 0.5 | -0.5 | 0.4 | 0.4 | -0.3 | -0.0 | -0.3 | -0.5 | 0.5 | -0.5 | 0.5 | -0.4 |
Vertical activity count, locomotor time 2 | 0.2 | 0.3 | 0.7 | 0.5 | -0.5 | 0.5 | -0.7 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.5 | -0.5 | 0.4 | 0.4 | -0.3 | 0.5 | 0.5 | -0.5 | 0.6 | -0.5 | -0.5 | 0.5 | -0.8 | 0.7 | 0.5 | -0.5 | 0.3 | -0.4 | 0.5 |
Seeking ratio, delayed vs. immediate footshock | 0.2 | 0.2 | 0.8 | 0.4 | -0.5 | 0.5 | -0.1 | 0.3 | -0.5 | 0.5 | 0.5 | -0.4 | 0.5 | -0.5 | 0.9 | 0.5 | -0.4 | 0.3 | 0.5 | -0.6 | -0.5 | -0.4 | -0.4 | 0.4 | 0.0 | 0.2 | 0.5 | -0.5 | 0.7 | -0.5 | 0.4 |
Co content in liver | 0.2 | 0.2 | 1.0 | -0.4 | 0.4 | -0.4 | 0.4 | -0.2 | 0.5 | -0.5 | -0.3 | 0.4 | -0.3 | 0.3 | -0.5 | -0.4 | 0.6 | -0.5 | -0.7 | 0.5 | -1.0 | 0.6 | 0.3 | -0.5 | 0.4 | -0.5 | -0.5 | 0.4 | -0.1 | 0.4 | -0.6 |
Mn content in liver | 0.2 | 0.2 | 1.5 | 0.4 | -0.2 | 0.2 | -0.3 | 0.4 | -0.4 | 0.5 | 0.6 | -0.4 | 0.6 | -0.6 | 0.2 | 0.4 | -0.5 | 0.5 | 0.6 | -0.5 | 1.2 | -0.5 | -0.1 | 0.1 | -0.3 | 0.1 | 0.5 | -0.4 | 0.0 | -0.4 | 0.5 |
Na content in liver | 0.2 | 0.2 | 1.4 | 0.4 | -0.2 | 0.2 | -0.1 | -0.1 | -0.4 | 0.4 | 0.6 | -0.4 | 0.6 | -0.6 | 0.1 | 0.4 | -0.5 | 0.5 | 0.6 | -0.5 | 1.2 | -0.5 | -0.1 | 0.2 | -0.1 | 0.1 | 0.5 | -0.3 | -0.1 | -0.3 | 0.5 |
BMI without tail | 0.1 | 0.1 | 0.4 | 0.4 | -0.2 | 0.2 | 0.1 | 0.6 | -0.4 | 0.4 | 0.5 | -0.4 | 0.5 | -0.5 | 0.4 | 0.4 | -0.3 | 0.4 | 0.3 | -0.4 | 0.0 | -0.3 | -0.3 | 0.1 | 0.1 | 0.1 | 0.4 | -0.4 | 0.6 | -0.4 | 0.4 |
Glucose | 0.1 | 0.1 | 0.4 | 0.4 | -0.1 | 0.1 | -0.1 | 0.6 | -0.4 | 0.4 | 0.3 | -0.4 | 0.3 | -0.3 | 0.3 | 0.4 | -0.3 | 0.4 | 0.2 | -0.3 | 0.4 | -0.3 | -0.2 | 0.1 | -0.1 | 0.2 | 0.3 | -0.3 | 0.7 | -0.4 | 0.3 |
Retroperitoneal fat weight | 0.1 | 0.2 | 1.1 | -0.5 | 0.2 | -0.2 | -0.4 | -1.1 | 0.4 | -0.4 | -0.5 | 0.5 | -0.5 | 0.5 | -0.1 | -0.5 | 0.2 | -0.5 | 0.0 | 0.4 | -0.1 | 0.2 | 0.4 | -0.2 | -0.2 | -0.2 | -0.3 | 0.4 | -0.8 | 0.5 | -0.4 |
Times rat made contact with spout | 0.1 | 0.1 | 0.3 | 0.2 | -0.4 | 0.4 | -0.3 | 0.1 | -0.3 | 0.3 | 0.3 | -0.2 | 0.3 | -0.3 | 0.4 | 0.2 | -0.3 | 0.2 | 0.5 | -0.3 | 0.1 | -0.4 | -0.3 | 0.6 | -0.3 | 0.5 | 0.3 | -0.3 | -0.0 | -0.2 | 0.3 |
Mean num. licks in bursts | 0.1 | 0.1 | 0.6 | 0.0 | -0.5 | 0.5 | -0.7 | -0.5 | -0.2 | 0.2 | 0.2 | 0.0 | 0.2 | -0.2 | 0.8 | 0.1 | -0.2 | -0.1 | 0.5 | -0.2 | -0.3 | -0.3 | -0.4 | 0.8 | -0.7 | 0.5 | 0.2 | -0.2 | -0.1 | -0.1 | 0.2 |
Indifference point AUC | 0.1 | 0.1 | 0.3 | -0.3 | 0.2 | -0.2 | -0.0 | -0.5 | 0.3 | -0.3 | -0.4 | 0.3 | -0.4 | 0.4 | -0.5 | -0.3 | 0.3 | -0.2 | -0.2 | 0.5 | 0.2 | 0.2 | 0.3 | -0.3 | 0.1 | -0.3 | -0.3 | 0.3 | -0.6 | 0.3 | -0.3 |
Median of all reaction times | 0.1 | 0.1 | 0.8 | 0.0 | -0.1 | 0.1 | -0.4 | 0.2 | 0.0 | -0.0 | -0.2 | -0.0 | -0.2 | 0.2 | 0.4 | 0.0 | -0.1 | -0.1 | -0.2 | 0.2 | -0.9 | 0.2 | -0.2 | -0.0 | -0.8 | 0.0 | -0.1 | -0.1 | 0.4 | -0.1 | -0.2 |
Cocaine response after cond. corrected | 0.1 | 0.1 | 0.5 | 0.1 | -0.2 | 0.2 | -0.3 | -0.3 | -0.2 | 0.2 | 0.2 | -0.0 | 0.2 | -0.2 | 0.7 | 0.1 | -0.3 | -0.0 | 0.4 | -0.2 | -0.2 | -0.4 | -0.1 | -0.0 | -0.3 | 0.1 | 0.2 | -0.2 | 0.1 | -0.1 | 0.3 |
Saline control response | 0.1 | 0.2 | 1.5 | -0.3 | 0.2 | -0.2 | 0.2 | 0.1 | 0.4 | -0.4 | -0.5 | 0.3 | -0.5 | 0.5 | -0.0 | -0.3 | 0.5 | -0.4 | -0.6 | 0.5 | -1.2 | 0.5 | 0.0 | 0.1 | 0.2 | -0.1 | -0.4 | 0.3 | -0.0 | 0.3 | -0.4 |
Pavlov. Cond. lever latency | 0.1 | 0.1 | 0.5 | 0.2 | 0.0 | -0.0 | 0.2 | -0.1 | -0.2 | 0.2 | 0.4 | -0.2 | 0.4 | -0.4 | -0.0 | 0.2 | -0.3 | 0.3 | 0.3 | -0.4 | 0.7 | -0.3 | 0.0 | -0.0 | 0.2 | -0.1 | 0.3 | -0.1 | -0.0 | -0.2 | 0.3 |
Pavlov. Cond. index score | 0.1 | 0.2 | 0.7 | 0.4 | -0.4 | 0.4 | -0.5 | 0.8 | -0.4 | 0.4 | 0.2 | -0.4 | 0.2 | -0.2 | 0.6 | 0.4 | -0.3 | 0.4 | 0.2 | -0.2 | -0.4 | -0.3 | -0.5 | 0.3 | -0.5 | 0.4 | 0.3 | -0.5 | 0.8 | -0.5 | 0.3 |
Pavlov. Cond. response bias | 0.1 | 0.2 | 1.0 | -0.3 | 0.3 | -0.3 | 0.3 | 0.0 | 0.4 | -0.4 | -0.6 | 0.3 | -0.6 | 0.6 | -0.2 | -0.4 | 0.5 | -0.4 | -0.6 | 0.6 | -1.0 | 0.5 | 0.2 | -0.4 | 0.3 | -0.3 | -0.4 | 0.3 | -0.1 | 0.3 | -0.5 |
Incentive Sensitization - Responses | 0.1 | 0.1 | 0.3 | 0.2 | 0.2 | -0.2 | 0.5 | 0.3 | -0.3 | 0.3 | 0.3 | -0.2 | 0.3 | -0.3 | -0.1 | 0.3 | -0.3 | 0.4 | 0.2 | -0.3 | 0.5 | -0.2 | 0.1 | -0.2 | 0.3 | -0.3 | 0.3 | -0.1 | 0.2 | -0.2 | 0.3 |
Incentive Sensitization - Breakpoint | 0.1 | 0.1 | 0.5 | 0.1 | 0.4 | -0.4 | 0.7 | 0.2 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.3 | 0.1 | -0.2 | 0.2 | -0.0 | -0.1 | 0.3 | -0.0 | 0.3 | -0.4 | 0.5 | -0.5 | 0.1 | 0.0 | 0.1 | -0.1 | 0.1 |
Short access total infusions | 0.1 | 0.2 | 0.4 | -0.4 | 0.4 | -0.4 | 0.2 | -0.2 | 0.4 | -0.4 | -0.5 | 0.4 | -0.5 | 0.5 | -0.4 | -0.4 | 0.3 | -0.4 | -0.4 | 0.4 | -0.7 | 0.5 | 0.5 | -0.3 | 0.4 | -0.5 | -0.4 | 0.4 | -0.3 | 0.4 | -0.5 |
Short access day 1 locomotion | 0.1 | 0.1 | 0.4 | 0.1 | 0.6 | -0.6 | 0.3 | 0.4 | -0.1 | 0.1 | 0.1 | -0.2 | 0.1 | -0.1 | -0.4 | 0.2 | -0.2 | 0.3 | -0.1 | -0.2 | -0.0 | -0.0 | 0.4 | -0.6 | 0.5 | -0.6 | 0.1 | 0.0 | 0.3 | -0.1 | 0.1 |
Short access day 10 total locomotion | 0.1 | 0.1 | 0.6 | -0.2 | 0.2 | -0.2 | -0.0 | -0.2 | 0.3 | -0.3 | -0.4 | 0.1 | -0.4 | 0.4 | -0.8 | -0.2 | 0.4 | -0.1 | -0.4 | 0.3 | 0.3 | 0.3 | 0.3 | -0.1 | 0.1 | -0.5 | -0.3 | 0.3 | -0.4 | 0.3 | -0.4 |
Short access total locomotion | 0.1 | 0.1 | 0.5 | -0.2 | 0.3 | -0.3 | -0.0 | -0.1 | 0.3 | -0.3 | -0.5 | 0.2 | -0.5 | 0.5 | -0.7 | -0.3 | 0.3 | -0.2 | -0.4 | 0.3 | -0.2 | 0.4 | 0.3 | -0.3 | 0.2 | -0.4 | -0.3 | 0.3 | -0.3 | 0.3 | -0.5 |
One hour access (shock baseline) | 0.1 | 0.1 | 0.4 | -0.1 | 0.5 | -0.5 | 0.6 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.3 | -0.0 | -0.1 | -0.0 | -0.1 | 0.1 | -0.3 | 0.1 | 0.4 | -0.4 | 0.7 | -0.6 | -0.1 | 0.1 | -0.0 | 0.1 | -0.1 |
Condit. Reinf. active minus inactive responses | 0.1 | 0.1 | 0.5 | -0.4 | 0.3 | -0.3 | 0.6 | -0.5 | 0.3 | -0.3 | -0.3 | 0.4 | -0.3 | 0.3 | -0.0 | -0.3 | 0.2 | -0.4 | -0.3 | 0.3 | -0.7 | 0.3 | 0.4 | -0.3 | 0.6 | -0.4 | -0.3 | 0.3 | -0.2 | 0.3 | -0.3 |
Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 0.5 | 0.3 | -0.2 | 0.2 | -0.1 | 0.1 | -0.3 | 0.3 | 0.3 | -0.2 | 0.3 | -0.3 | 0.7 | 0.3 | -0.4 | 0.2 | 0.4 | -0.3 | -0.2 | -0.3 | -0.3 | 0.3 | -0.1 | 0.2 | 0.3 | -0.3 | 0.4 | -0.3 | 0.3 |
Time in novel zone, hab. session 1 | 0.1 | 0.1 | 0.4 | 0.4 | -0.5 | 0.5 | -0.1 | 0.6 | -0.3 | 0.3 | 0.2 | -0.4 | 0.2 | -0.2 | 0.2 | 0.3 | -0.1 | 0.4 | 0.0 | -0.2 | 0.3 | -0.2 | -0.5 | 0.5 | -0.2 | 0.5 | 0.2 | -0.3 | 0.6 | -0.4 | 0.2 |
Time in novel zone, hab. session 2 | 0.1 | 0.1 | 1.2 | -0.1 | 0.0 | -0.0 | -0.2 | -0.2 | 0.1 | -0.1 | -0.1 | 0.0 | -0.1 | 0.1 | -0.6 | -0.1 | 0.2 | 0.1 | -0.0 | 0.1 | 1.1 | 0.0 | 0.1 | 0.1 | -0.2 | 0.1 | -0.1 | 0.2 | -0.5 | 0.1 | -0.1 |
Total zone transitions, hab. session 2 | 0.1 | 0.1 | 0.2 | -0.3 | 0.2 | -0.2 | 0.2 | -0.5 | 0.3 | -0.3 | -0.2 | 0.4 | -0.2 | 0.2 | -0.2 | -0.3 | 0.3 | -0.4 | -0.1 | 0.2 | -0.3 | 0.2 | 0.2 | -0.4 | 0.2 | -0.4 | -0.3 | 0.3 | -0.4 | 0.3 | -0.2 |
Pavlov. Cond. lever latency | 0.1 | 0.1 | 1.0 | 0.1 | -0.1 | 0.1 | 0.1 | -0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 | -0.2 | -0.2 | 0.1 | -0.2 | 0.2 | 0.3 | -0.2 | 1.0 | -0.3 | 0.0 | 0.1 | 0.0 | 0.1 | 0.2 | -0.1 | -0.2 | -0.1 | 0.2 |
Pavlov. Cond. index score | 0.1 | 0.2 | 0.5 | 0.3 | -0.5 | 0.5 | -0.7 | 0.5 | -0.3 | 0.3 | 0.4 | -0.3 | 0.4 | -0.4 | 0.7 | 0.3 | -0.2 | 0.2 | 0.2 | -0.2 | -0.3 | -0.2 | -0.6 | 0.4 | -0.7 | 0.4 | 0.3 | -0.4 | 0.6 | -0.4 | 0.2 |
Pavlov. Cond. latency score | 0.1 | 0.1 | 0.4 | 0.2 | -0.4 | 0.4 | -0.6 | 0.5 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 | -0.2 | 0.6 | 0.2 | -0.1 | 0.1 | 0.0 | -0.1 | -0.6 | -0.1 | -0.4 | 0.3 | -0.6 | 0.3 | 0.1 | -0.3 | 0.5 | -0.2 | 0.1 |
Pavlov. Cond. response bias | 0.1 | 0.1 | 0.9 | -0.3 | 0.0 | -0.0 | -0.1 | -0.1 | 0.3 | -0.3 | -0.2 | 0.3 | -0.2 | 0.2 | 0.2 | -0.3 | 0.3 | -0.4 | -0.3 | 0.3 | -0.9 | 0.3 | -0.0 | -0.1 | -0.1 | -0.0 | -0.3 | 0.2 | -0.1 | 0.2 | -0.3 |
Bone: elastic work | 0.1 | 0.1 | 0.2 | -0.3 | 0.3 | -0.3 | -0.0 | -0.2 | 0.3 | -0.3 | -0.4 | 0.3 | -0.4 | 0.4 | -0.2 | -0.3 | 0.2 | -0.3 | -0.4 | 0.4 | -0.4 | 0.4 | 0.1 | -0.2 | -0.1 | -0.0 | -0.3 | 0.3 | -0.2 | 0.3 | -0.4 |
Bone: trabecular tissue density | 0.1 | 0.1 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | -0.1 | 0.4 | -0.4 | -0.5 | 0.3 | -0.5 | 0.5 | -0.4 | -0.3 | 0.4 | -0.3 | -0.5 | 0.5 | -0.1 | 0.4 | 0.3 | -0.3 | 0.4 | -0.3 | -0.4 | 0.4 | -0.3 | 0.3 | -0.4 |
Delta time in closed arm before/after self-admin | 0.1 | 0.1 | 0.5 | 0.2 | -0.1 | 0.1 | -0.1 | 0.5 | -0.3 | 0.3 | 0.3 | -0.2 | 0.3 | -0.3 | 0.7 | 0.3 | -0.2 | 0.1 | 0.3 | -0.3 | -0.7 | -0.4 | -0.4 | 0.2 | -0.1 | 0.5 | 0.3 | -0.3 | 0.4 | -0.3 | 0.4 |
Sum of active levers in priming session hrs 5-6 | 0.1 | 0.1 | 0.3 | -0.4 | 0.2 | -0.2 | -0.1 | -0.5 | 0.4 | -0.4 | -0.5 | 0.4 | -0.5 | 0.5 | -0.3 | -0.4 | 0.5 | -0.4 | -0.4 | 0.5 | -0.5 | 0.4 | 0.2 | -0.2 | -0.1 | -0.1 | -0.4 | 0.4 | -0.4 | 0.4 | -0.4 |
Time to tail flick, vehicle, after self-admin | 0.1 | 0.1 | 0.4 | 0.2 | 0.7 | -0.7 | 0.2 | 0.5 | -0.1 | 0.1 | 0.1 | -0.2 | 0.1 | -0.1 | -0.3 | 0.2 | -0.1 | 0.3 | -0.2 | -0.2 | 0.3 | -0.1 | 0.2 | -0.5 | 0.2 | -0.4 | 0.0 | -0.0 | 0.3 | -0.1 | 0.2 |
Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.4 | 0.3 | -0.0 | 0.0 | 0.6 | 0.3 | -0.4 | 0.4 | 0.4 | -0.3 | 0.4 | -0.4 | 0.2 | 0.4 | -0.6 | 0.4 | 0.3 | -0.3 | 0.6 | -0.4 | -0.1 | 0.2 | 0.3 | 0.1 | 0.4 | -0.2 | 0.5 | -0.3 | 0.4 |
Rest time, locomotor task time 1 | 0.1 | 0.1 | 0.4 | -0.3 | 0.7 | -0.7 | 0.3 | -0.5 | 0.3 | -0.3 | -0.2 | 0.3 | -0.2 | 0.2 | -0.1 | -0.3 | 0.2 | -0.3 | -0.3 | 0.2 | -0.5 | 0.2 | 0.5 | -0.6 | 0.3 | -0.4 | -0.3 | 0.3 | -0.2 | 0.3 | -0.2 |
Distance moved, locomotor task time 1 | 0.1 | 0.1 | 0.3 | -0.3 | -0.2 | 0.2 | -0.1 | 0.1 | 0.3 | -0.3 | -0.4 | 0.3 | -0.4 | 0.4 | -0.4 | -0.3 | 0.4 | -0.3 | -0.3 | 0.4 | 0.1 | 0.4 | -0.0 | 0.2 | -0.1 | 0.0 | -0.3 | 0.3 | -0.4 | 0.3 | -0.6 |
Rest time, locomotor task time 2 | 0.1 | 0.2 | 0.4 | 0.4 | -0.0 | 0.0 | -0.0 | 0.5 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 | -0.4 | 0.5 | 0.5 | -0.6 | 0.4 | 0.4 | -0.5 | 0.3 | -0.4 | -0.1 | 0.1 | 0.1 | 0.1 | 0.4 | -0.4 | 0.6 | -0.4 | 0.4 |
Food seeking constrained by brief footshock | 0.1 | 0.1 | 1.0 | 0.1 | -0.7 | 0.7 | -0.8 | -0.1 | -0.1 | 0.1 | 0.0 | -0.1 | 0.0 | -0.0 | 0.3 | 0.0 | -0.1 | -0.0 | 0.3 | 0.0 | 0.1 | -0.1 | -0.5 | 0.7 | -1.0 | 0.6 | 0.1 | -0.2 | -0.1 | -0.1 | -0.0 |
Seeking ratio, punishment vs. effort | 0.1 | 0.1 | 0.5 | 0.1 | -0.5 | 0.5 | -0.3 | -0.0 | -0.1 | 0.1 | -0.0 | -0.1 | -0.0 | 0.0 | 0.3 | 0.1 | -0.0 | 0.1 | 0.1 | -0.1 | -0.0 | -0.1 | -0.4 | 0.5 | -0.7 | 0.6 | 0.1 | -0.1 | 0.1 | -0.1 | 0.0 |
Fe content in liver | 0.1 | 0.1 | 0.2 | -0.4 | 0.4 | -0.4 | 0.2 | -0.3 | 0.4 | -0.4 | -0.2 | 0.4 | -0.2 | 0.2 | -0.3 | -0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 | 0.4 | 0.4 | -0.3 | 0.2 | -0.3 | -0.4 | 0.3 | -0.3 | 0.3 | -0.4 |
Heart weight | 0.0 | 0.0 | 0.1 | -0.0 | 0.2 | -0.2 | 0.2 | -0.2 | -0.1 | 0.1 | -0.0 | 0.0 | -0.0 | 0.0 | 0.2 | 0.0 | -0.2 | 0.0 | 0.2 | -0.0 | -0.1 | -0.1 | 0.3 | -0.3 | 0.2 | -0.2 | 0.1 | -0.0 | 0.0 | -0.0 | -0.0 |
Tail length | 0.0 | 0.1 | 0.5 | -0.3 | 0.3 | -0.3 | 0.7 | 0.1 | 0.3 | -0.3 | -0.3 | 0.3 | -0.3 | 0.3 | -0.4 | -0.3 | 0.4 | -0.2 | -0.4 | 0.3 | -0.0 | 0.3 | 0.5 | -0.6 | 0.4 | -0.7 | -0.3 | 0.4 | -0.3 | 0.3 | -0.3 |
Conditioned locomotion | 0.0 | 0.0 | 0.4 | 0.0 | 0.0 | -0.0 | 0.6 | -0.1 | 0.0 | -0.1 | -0.0 | -0.1 | -0.0 | 0.0 | -0.4 | -0.0 | 0.1 | 0.1 | -0.2 | 0.1 | 0.2 | 0.2 | 0.2 | -0.2 | 0.6 | -0.3 | -0.1 | 0.1 | 0.1 | 0.0 | -0.1 |
Condit. Reinf. active minus inactive responses | 0.0 | 0.0 | 0.1 | -0.1 | 0.2 | -0.2 | 0.4 | 0.2 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.3 | -0.1 | 0.1 | 0.0 | -0.0 | 0.1 | 0.3 | 0.0 | 0.2 | -0.3 | 0.4 | -0.2 | -0.1 | 0.1 | -0.2 | 0.1 | -0.0 |
Condit. Reinf. lever presses | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 | 0.1 | 0.1 | -0.1 | -0.2 | 0.1 | -0.2 | 0.2 | -0.0 | -0.1 | 0.2 | -0.1 | -0.1 | 0.2 | -0.2 | 0.1 | -0.1 | 0.1 | -0.2 | 0.3 | -0.1 | 0.1 | -0.2 | 0.1 | -0.1 |
Short access day 1 total infusions | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | -0.1 | 0.1 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 | -0.2 | 0.1 | 0.2 | -0.3 | 0.2 | 0.1 | -0.2 | -0.1 | -0.1 | 0.1 | -0.1 | 0.2 | -0.4 | 0.2 | -0.1 | 0.3 | -0.2 | 0.2 |
Locomotion velocity, session 7 | 0.0 | 0.0 | 0.2 | -0.1 | 0.1 | -0.1 | 0.5 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 | 0.2 | -0.1 | -0.1 | 0.1 | 0.0 | 0.1 | 0.2 | -0.1 | 0.5 | -0.2 | -0.1 | 0.2 | -0.2 | 0.1 | -0.1 |
Incentive salience index mean | 0.0 | 0.0 | 0.2 | 0.1 | -0.2 | 0.2 | 0.1 | 0.2 | -0.2 | 0.2 | 0.1 | -0.1 | 0.1 | -0.1 | 0.4 | 0.1 | -0.2 | 0.1 | 0.1 | -0.1 | -0.4 | -0.1 | -0.1 | 0.1 | 0.1 | 0.1 | 0.1 | -0.2 | 0.3 | -0.2 | 0.1 |
Total locomotion distance, hab. session 1 | 0.0 | 0.0 | 0.3 | -0.2 | -0.3 | 0.3 | -0.0 | -0.2 | 0.2 | -0.2 | -0.3 | 0.2 | -0.3 | 0.3 | -0.0 | -0.2 | 0.2 | -0.3 | -0.2 | 0.3 | -0.6 | 0.2 | -0.1 | 0.0 | -0.0 | 0.1 | -0.2 | 0.1 | -0.1 | 0.2 | -0.3 |
Locomotion velocity, hab. session 1 | 0.0 | 0.0 | 0.2 | -0.1 | -0.3 | 0.3 | -0.1 | -0.1 | 0.1 | -0.1 | -0.2 | 0.1 | -0.2 | 0.2 | 0.0 | -0.1 | 0.1 | -0.2 | -0.1 | 0.2 | -0.4 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | 0.0 | -0.0 | 0.1 | -0.2 |
Time in familiar zone, hab. session 2 | 0.0 | 0.0 | 0.4 | 0.1 | -0.0 | 0.0 | 0.3 | 0.2 | -0.2 | 0.2 | 0.1 | -0.1 | 0.1 | -0.1 | 0.4 | 0.2 | -0.2 | 0.1 | 0.0 | -0.1 | -0.6 | -0.1 | -0.1 | -0.0 | 0.3 | -0.0 | 0.1 | -0.2 | 0.4 | -0.2 | 0.1 |
Locomotion velocity, hab. session 2 | 0.0 | 0.0 | 0.2 | -0.2 | 0.1 | -0.1 | 0.2 | -0.4 | 0.2 | -0.2 | -0.2 | 0.3 | -0.2 | 0.2 | -0.0 | -0.2 | 0.2 | -0.3 | -0.1 | 0.2 | -0.5 | 0.2 | 0.2 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.2 | 0.2 | -0.2 |
Pavlov. Cond. magazine entry latency | 0.0 | 0.0 | 0.4 | -0.2 | -0.0 | 0.0 | -0.4 | 0.0 | 0.1 | -0.1 | 0.0 | 0.2 | 0.0 | -0.0 | 0.4 | -0.1 | 0.2 | -0.3 | -0.1 | 0.1 | -0.6 | 0.1 | -0.1 | 0.0 | -0.3 | 0.0 | -0.1 | 0.0 | 0.0 | 0.1 | -0.1 |
Pavlov. Cond. change in total contacts | 0.0 | 0.0 | 0.3 | 0.0 | -0.1 | 0.1 | 0.0 | 0.4 | -0.0 | 0.0 | 0.0 | -0.0 | 0.0 | -0.0 | 0.3 | 0.1 | 0.0 | 0.0 | -0.1 | 0.0 | -0.6 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.0 | -0.1 | 0.3 | -0.1 | -0.0 |
Pavlov. Cond. magazine entry number | 0.0 | 0.0 | 0.2 | 0.1 | 0.2 | -0.2 | 0.4 | -0.0 | -0.1 | 0.1 | 0.0 | -0.1 | 0.0 | -0.0 | -0.3 | 0.1 | -0.1 | 0.2 | 0.1 | -0.1 | 0.5 | -0.1 | 0.2 | -0.1 | 0.3 | -0.2 | 0.1 | -0.0 | -0.1 | -0.1 | 0.1 |
Total resting periods, locomotor time 1 | 0.0 | 0.0 | 0.2 | -0.2 | 0.1 | -0.1 | -0.3 | -0.3 | 0.1 | -0.1 | -0.3 | 0.2 | -0.3 | 0.3 | 0.3 | -0.1 | 0.0 | -0.2 | -0.1 | 0.1 | -0.5 | 0.1 | -0.0 | 0.0 | -0.3 | 0.1 | -0.1 | 0.1 | 0.0 | 0.1 | -0.1 |
Progressive ratio | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | -0.1 | -0.0 | 0.0 | -0.0 | 0.0 | 0.1 | 0.0 | 0.1 | -0.1 | -0.1 | 0.0 | -0.2 | 0.0 | 0.2 | 0.1 | 0.2 | -0.1 | 0.2 | -0.1 | 0.2 | -0.2 | 0.1 | -0.0 | -0.1 | -0.0 | 0.0 |
Latency to leave start box in cocaine runway | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.2 | -0.1 | 0.1 | -0.1 | -0.0 | 0.0 | -0.0 | 0.0 | -0.2 | -0.1 | 0.0 | -0.0 | -0.1 | 0.1 | 0.1 | 0.1 | 0.1 | -0.0 | 0.2 | 0.0 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 |
Mg content in liver | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.0 | -0.2 | 0.2 | 0.3 | -0.1 | 0.3 | -0.3 | 0.2 | 0.2 | -0.2 | 0.1 | 0.2 | -0.2 | -0.2 | -0.1 | 0.0 | -0.1 | 0.1 | -0.1 | 0.2 | -0.1 | 0.2 | -0.2 | 0.2 |
Rb content in liver | 0.0 | 0.0 | 0.2 | -0.1 | 0.3 | -0.3 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.4 | -0.1 | 0.1 | -0.1 | -0.2 | 0.1 | -0.0 | 0.2 | 0.2 | -0.2 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.