Hub : Genes

Casc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000009716	0.04	0.03	6.9e-03	0.01	0.01	0	0.01	5.7e-02	1.6e-02	2.4e-01	1.6e-02
2	Liver	mRNA stability	ENSRNOG00000009716	0.11	0.07	7.9e-11	0.1	0.09	0.09	0.09	9.7e-11	5.2e-10	4.5e-10	6.2e-10
3	NAcc	mRNA stability	ENSRNOG00000009716	0.32	0.14	8.1e-03	0	0.01	0	0.01	3.2e-01	1.1e-01	1.2e-01	6.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	1.2	3.9	8.0	1.9	2.8	-0.3
BMI without tail	0.1	0.2	0.5	0.3	0.7	-0.0
Body weight	2.8	11.7	20.0	3.5	4.5	-1.7
Epididymis fat weight	0.0	0.0	0.0	-0.2	0.2	-0.1
Glucose	0.2	0.3	0.7	-0.3	-0.1	0.9
Heart weight	3.0	4.3	5.0	2.2	2.2	-1.8
Left kidney weight	1.5	4.2	4.4	2.0	2.0	-2.1
Right kidney weight	0.1	0.2	0.4	0.4	0.6	-0.1
Tail length	0.3	0.9	1.5	0.9	0.7	-1.2
Length with tail	2.0	7.2	7.9	2.8	2.8	-2.4
Length without tail	1.8	3.9	5.9	2.1	2.4	-1.2
Liver weight, left	0.0	0.1	0.1	-0.2	-0.3	-0.2
Liver weight, right	0.2	0.4	0.8	-0.6	-0.9	0.3
Parametrial fat weight	2.1	4.0	5.4	-2.1	-2.3	1.5
Retroperitoneal fat weight	0.0	0.0	0.0	0.2	0.2	-0.1
Intraocular pressure	2.1	3.0	4.8	1.8	2.2	-0.9
Extensor digitorum longus weight	7.3	29.5	41.1	5.7	6.4	-3.8
Soleus weight	0.8	2.4	6.3	-0.9	0.3	2.5
Tibialis anterior weight	0.9	3.2	6.0	1.8	2.5	-0.4
Tibia length	0.8	2.3	4.7	1.4	2.2	0.4
Number of licking bursts	0.9	1.1	1.8	-1.1	-0.5	1.3
Food consumed during 24 hour testing period	0.4	0.5	0.6	0.7	0.8	-0.5
Times rat made contact with spout	1.3	1.5	1.5	-1.2	-1.2	1.2
Mean time between licks in bursts	0.7	0.9	2.0	0.7	1.4	-0.6
Mean num. licks in bursts	0.1	0.1	0.2	0.2	-0.4	-0.4
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.3	0.1	0.2
Water consumed over 24 hours	0.0	0.0	0.0	0.0	-0.1	-0.0
Indifference point 0 sec	0.9	1.5	2.6	-1.4	-1.6	0.0
Indifference point AUC	0.0	0.0	0.0	0.0	0.2	0.2
Indifference point function ln k	0.2	0.3	0.6	0.5	0.3	-0.8
Indifference point function log k	0.2	0.3	0.6	0.5	0.3	-0.8
Delay discounting total patch changes 0 sec	0.7	1.1	1.8	-1.2	-1.4	-0.0
Delay discounting total patch changes 12 sec	5.2	6.9	8.8	-3.0	-2.8	2.0
Delay discounting total patch changes 18 sec	0.4	0.5	0.9	-0.9	-0.8	0.4
Delay discounting total patch changes 24 sec	1.4	1.8	2.2	-1.4	-1.5	1.1
Delay discounting total patch changes 6 sec	1.4	2.1	3.1	-1.6	-1.8	0.7
Delay discounting time to switch 0 sec	0.1	0.2	0.3	-0.5	-0.3	0.4
Delay discounting water rate 0 sec	0.1	0.1	0.1	-0.1	-0.4	-0.3
Delay discounting water rate 12 sec	0.1	0.1	0.3	0.3	0.1	-0.5
Delay discounting water rate 18 sec	0.8	1.1	1.1	-1.1	-1.0	1.0
Delay discounting water rate 24 sec	0.5	0.7	1.3	-0.9	-1.1	0.2
Delay discounting water rate 6 sec	1.3	1.9	3.3	-1.4	-1.8	0.6
Locomotor activity	1.3	2.1	2.7	-1.6	-1.1	1.7
Locomotor testing distance	2.2	3.7	4.4	-2.1	-2.0	1.6
Locomotor testing rearing	3.5	5.6	9.5	-2.5	-3.1	0.8
Light reinforcement 1	2.3	4.2	6.3	-2.3	-2.5	1.1
Light reinforcement 2	1.0	1.4	1.9	-1.1	-0.9	1.4
Reaction time number correct	0.2	0.3	0.5	0.7	0.6	-0.2
Reaction time mean minus median	0.3	0.4	0.7	0.4	0.9	-0.5
Reaction time mean minus median AUC	0.0	0.0	0.1	0.0	0.2	-0.0
Reaction time num false alarms	1.2	1.7	2.3	-1.3	-1.1	1.5
Reaction time num false alarms AUC	1.2	1.6	2.2	-1.3	-0.9	1.5
Reaction time trials correct on left	0.2	0.3	0.5	0.7	0.6	-0.2
Reaction time trials on left	0.2	0.3	0.5	0.7	0.6	-0.2
Reaction time mean	0.2	0.3	0.7	-0.1	-0.4	-0.9
Reaction time mean AUC	0.3	0.4	0.9	-0.0	-0.4	-0.9
Median of all reaction times	0.5	0.7	1.5	-0.6	-1.2	-0.6
Reaction time omissions	1.0	1.3	2.0	-1.3	-1.4	0.7
Reaction time false alarm rate	1.3	1.8	2.2	-1.5	-1.1	1.4
Reaction time premature initiation rate	0.3	0.4	0.7	-0.6	-0.9	0.4
Reaction time premature initiations	0.0	0.0	0.1	0.1	-0.3	0.0
Std. dev. reaction times	0.0	0.1	0.1	0.0	0.3	-0.3
Reaction time trials completed	0.2	0.3	0.5	0.7	0.6	-0.2
Reaction time trials AUC	0.2	0.3	0.5	0.7	0.6	-0.3
Social response proportion	0.3	0.3	0.5	0.7	0.7	-0.0
Social responses	0.2	0.2	0.4	-0.5	-0.0	0.7
Social time	0.5	0.6	1.4	-0.6	-0.2	1.2
Conditioned locomotion	0.1	0.1	0.2	-0.2	-0.5	-0.2
Cocaine response after cond. corrected	2.2	2.5	4.9	-1.3	-0.9	2.2
Cocaine response after cond. not corrected	2.7	3.0	5.9	-1.5	-1.0	2.4
Cocaine response before conditioning	0.0	0.0	0.1	-0.1	-0.2	0.1
Saline control response	0.3	0.4	0.9	0.0	0.5	1.0
Condit. Reinf. active minus inactive responses	1.2	1.4	2.0	-1.4	-1.3	0.8
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.8	-1.3	-1.2	1.0
Condit. Reinf. active responses	2.1	2.9	3.8	-2.0	-1.7	1.4
Condit. Reinf. inactive responses	2.1	2.6	3.1	-1.8	-1.6	1.5
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.3	-0.4	-0.1
Condit. Reinf. lever reinforcers received	1.8	2.5	3.4	-1.8	-1.7	1.1
Pavlov. Cond. lever latency	0.4	0.5	0.7	0.9	0.8	-0.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.0	0.1
Pavlov. Cond. change in total contacts	0.3	0.5	0.7	-0.9	-0.8	0.1
Pavlov. Cond. index score	0.3	0.4	0.5	-0.7	-0.5	0.6
Pavlov. Cond. latency score	0.2	0.2	0.3	-0.5	-0.4	0.5
Pavlov. Cond. lever contacts	1.0	1.4	1.8	-1.3	-1.1	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.2	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	2.4	3.1	3.8	1.7	1.6	-1.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	-0.5	-0.4	0.4
Pavlov. Cond. response bias	1.3	1.8	2.1	-1.4	-1.4	1.2
Conditioned reinforcement - actives	0.6	0.6	0.8	-0.9	-0.9	0.5
Conditioned reinforcement - inactives	1.3	1.5	3.3	-1.1	-1.8	0.0
Conditioned locomotion	0.9	1.1	1.5	-1.2	-0.7	1.1
Intermittent access intake day 1-15 change	0.4	0.4	1.0	-0.4	-1.0	-0.2
Intermittent access intake escalation	0.4	0.4	1.0	-0.5	-1.0	-0.1
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.1	-0.4	-0.0
Intermitt. access day 1 inactive lever presses	1.4	1.6	3.1	-1.2	-1.8	0.4
Intermitt. access day 15 inactive lever presses	2.7	3.0	5.3	-1.8	-2.3	0.6
Intermitt. access escalation Index	1.4	1.2	2.3	1.2	1.5	-0.2
Intermittent access day 1 total infusions	0.2	0.2	0.3	-0.5	-0.5	0.4
Intermittent access day 15 total infusions	0.4	0.5	1.2	-0.4	-1.1	-0.2
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.5	-0.6	-1.2	0.1
Intermittent access total infusions	0.2	0.2	0.6	-0.2	-0.8	-0.1
Intermittent access day 1 locomotion	0.2	0.2	0.2	-0.5	-0.4	0.2
Intermittent access day 15 total locomotion	0.5	0.5	0.7	-0.8	-0.8	0.5
Intermittent access total locomotion	0.5	0.6	0.9	-0.8	-1.0	0.2
Intermittent access standard deviation	1.7	1.8	4.3	-1.0	-2.1	-0.4
Cocaine induced anxiety	0.9	1.1	2.3	0.8	1.5	0.4
Post-drug Anxiety	0.2	0.2	0.2	0.3	0.5	0.5
Baseline Anxiety	0.5	0.6	1.3	-0.6	-1.1	0.1
Lifetime Intake	0.2	0.3	0.7	-0.2	-0.8	-0.3
Incentive Sensitization - Responses	1.4	1.4	2.1	-1.3	-1.4	0.6
Incentive Sensitization - Breakpoint	1.3	1.4	1.9	-1.3	-1.4	0.7
Progressive ratio test 1 active lever presses	0.3	0.3	0.4	-0.5	-0.7	0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	-0.4	-0.6	0.4
Progressive ratio test 1 inactive lever presses	0.9	0.9	2.1	-0.8	-1.4	-0.1
Progressive ratio test 2 active lever presses	0.9	0.9	1.8	-1.0	-1.3	0.3
Progressive ratio test 2 breakpoint	0.6	0.7	1.3	-0.8	-1.1	0.2
Progressive ratio test 2 inactive lever presses	0.5	0.5	1.2	-0.6	-1.1	-0.0
Total sessions with >9 infusions	0.3	0.4	0.9	-0.3	-1.0	-0.4
Short access day 1 total inactive lever presses	1.5	1.7	3.7	-1.1	-1.9	0.3
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.3	-0.2	-0.5
Short access day 1 total infusions	0.5	0.5	1.1	-0.2	-1.1	-0.6
Short access day 10 total infusions	0.4	0.4	0.5	-0.7	-0.7	0.6
Short access total infusions	0.3	0.4	0.7	-0.0	-0.8	-0.6
Short access day 1 locomotion	2.4	2.6	4.5	-1.7	-2.1	0.5
Short access day 10 total locomotion	1.6	1.7	2.3	-1.5	-1.1	1.3
Short access total locomotion	0.4	0.4	0.7	-0.4	-0.8	-0.5
Compulsive drug intake	1.7	1.7	3.2	1.2	0.7	-1.8
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.1	-0.1	-0.3
One hour access (shock baseline)	0.5	0.6	0.7	-0.7	-0.8	0.8
Number of responses in last shaping day	0.6	0.6	1.2	0.0	-0.8	-1.1
Context. condit. distance diff. score	2.8	3.4	4.7	2.1	1.0	-2.2
Locomotion velocity, session 1	0.2	0.2	0.4	0.3	0.6	0.1
Locomotion distance, session 1	0.7	0.9	1.9	0.9	1.4	-0.3
Locomotion velocity, session 2	0.2	0.2	0.3	0.4	0.6	-0.4
Locomotion distance, session 2	0.1	0.2	0.4	-0.4	0.1	0.6
Locomotion velocity, session 3	0.2	0.2	0.6	0.1	-0.1	-0.8
Locomotion distance, session 3	0.1	0.1	0.1	0.3	0.4	-0.3
Stereotopy head waving bouts, day 3	1.1	1.3	2.3	-1.1	-1.5	0.6
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.0	-0.1	0.1
Locomotion velocity, session 7	0.3	0.4	1.0	0.4	1.0	0.1
Locomotion distance, session 7	0.2	0.2	0.6	0.4	0.7	0.0
Stereotopy head waving bouts, day 7	0.5	0.6	0.7	-0.7	-0.8	0.8
Stereotopy head waving duration, day 7	0.3	0.3	0.4	-0.5	-0.6	0.6
Locomotion velocity, session 8	6.3	7.5	9.7	3.1	2.9	-2.1
Locomotion distance, session 8	0.8	1.1	1.4	1.2	1.1	-0.9
Degree of sensitization distance	0.9	1.0	1.5	1.1	1.2	-0.5
Degree of sensitization stereotypy	1.2	1.3	1.5	-1.0	-1.1	1.2
Condit. Reinf. active minus inactive responses	0.4	0.4	0.9	-0.5	-0.9	-0.2
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	-0.4	-0.9	-0.6
Condit. Reinf. active responses	0.4	0.5	1.0	-0.6	-1.0	0.1
Condit. Reinf. inactive responses	0.4	0.5	1.0	-0.5	-0.5	1.0
Incentive salience index mean	1.1	1.3	2.0	-1.3	-1.4	0.5
Condit. Reinf. lever presses	0.9	1.2	1.6	-1.3	-1.0	1.0
Time in familiar zone, hab. session 1	1.3	1.3	2.6	-1.0	-0.5	1.6
Time in novel zone, hab. session 1	0.4	0.4	0.8	0.0	-0.6	-0.9
Total zone transitions, hab. session 1	1.4	2.0	2.7	1.7	1.3	-1.3
Total locomotion distance, hab. session 1	0.2	0.2	0.5	0.5	-0.3	-0.7
Locomotion velocity, hab. session 1	0.4	0.5	0.8	0.8	0.4	-0.9
Time in familiar zone, hab. session 2	0.6	0.6	0.9	-0.7	-0.9	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	-0.2	-0.2
Total zone transitions, hab. session 2	0.5	0.6	0.9	0.9	0.9	-0.4
Total locomotion distance, hab. session 2	0.0	0.0	0.1	0.2	0.3	0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.4	0.5	-0.0
Novel to familiar place preference ratio	1.3	1.4	1.6	1.3	1.2	-1.1
Novelty place preference	1.4	1.5	1.7	1.3	1.2	-1.2
Time in novel zone, NPP test	0.7	0.7	0.8	0.9	0.8	-0.8
Total zone transitions, NPP test	0.1	0.2	0.3	0.2	0.4	0.6
Total locomotion distance, NPP test	0.2	0.3	0.6	-0.4	-0.3	0.8
Locomotion velocity, NPP test	0.0	0.1	0.1	0.2	0.3	0.2
Pavlov. Cond. lever latency	3.8	4.9	6.1	2.4	1.7	-2.5
Pavlov. Cond. magazine entry latency	9.2	11.8	13.1	-3.6	-3.6	3.1
Pavlov. Cond. change in total contacts	5.2	5.5	8.6	-2.4	-2.9	1.4
Pavlov. Cond. index score	8.4	10.7	12.2	-3.5	-3.2	3.2
Pavlov. Cond. latency score	6.9	8.9	9.9	-3.1	-2.7	3.1
Pavlov. Cond. lever contacts	3.6	4.3	5.7	-2.2	-1.5	2.4
Pavlov. Cond. magazine entry number	10.3	12.9	15.9	3.8	4.0	-3.0
Pavlov. Cond. intertrial magazine entries	1.6	2.0	2.3	1.5	1.4	-1.3
Pavlov. Cond. lever-magazine prob. diff.	8.8	11.0	12.6	-3.5	-3.3	3.1
Pavlov. Cond. response bias	7.6	9.3	11.2	-3.2	-3.3	2.5
Bone: apparent density	2.4	3.9	4.4	-2.0	-2.1	1.8
Bone surface	0.2	0.4	0.9	-0.6	-0.2	0.9
Bone volume	0.8	1.3	2.4	-1.1	-0.7	1.6
Bone: connectivity density	2.8	4.4	5.8	-2.2	-2.4	1.6
Bone: cortical apparent density	3.0	3.9	7.9	-1.9	-2.8	0.5
Bone: cortical area	0.1	0.1	0.2	-0.3	-0.3	0.5
Bone: cortical porosity	0.8	0.8	1.8	-0.7	-0.4	1.4
Bone: cortical porosity	0.9	1.0	2.5	-0.6	-0.3	1.6
Bone: cortical thickness	0.5	0.8	1.6	-0.8	-1.3	0.5
Bone: cortical thickness	2.9	3.4	6.8	-1.7	-2.6	0.7
Bone: cortical tissue density	3.0	3.9	7.8	-1.9	-2.8	0.5
Bone: elastic displacement	0.0	0.0	0.0	-0.0	0.0	-0.1
Bone: elastic work	0.2	0.2	0.2	-0.4	-0.5	0.5
Bone: endosteal estimation	0.8	1.8	4.1	1.1	2.0	0.1
Bone: endosteal perimeter	0.6	1.2	2.4	1.0	1.6	-0.5
Bone: final force	1.6	2.6	4.6	-1.5	-1.1	2.1
Bone: final moment	1.4	2.2	4.3	-1.3	-0.9	2.1
Bone: marrow area	0.8	1.7	3.8	1.1	2.0	0.0
Bone: maximum diameter	0.1	0.2	0.4	-0.5	-0.2	0.6
Bone: maximum force	0.3	0.5	1.2	-0.4	0.1	1.1
Bone: maximum moment	0.2	0.4	1.0	-0.2	0.3	1.0
Bone: minimum diameter	0.3	0.5	1.1	0.5	1.1	0.0
Bone: periosteal estimation	0.1	0.2	0.4	0.1	0.6	0.6
Bone: periosteal perimeter	0.2	0.3	0.8	0.4	0.9	0.2
Bone: post-yield work	0.9	1.3	2.0	1.2	1.4	-0.6
Bone: stiffness	0.1	0.2	0.6	-0.2	-0.1	0.8
Bone: tissue strength	0.7	0.6	1.2	0.7	1.1	-0.4
Bone: trabecular number	5.5	8.6	9.3	-3.0	-3.0	2.7
Bone: trabecular spacing	0.7	0.9	1.8	0.9	1.3	0.2
Bone: trabecular thickness	0.1	0.2	0.2	-0.4	-0.4	0.3
Bone: trabecular tissue density	0.7	0.9	2.2	0.8	0.2	-1.5
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.2	0.2	-0.4
Distance traveled before self-admin	0.1	0.1	0.1	-0.1	0.3	0.3
Distance traveled after self-admin	1.5	1.7	3.7	1.1	1.9	-0.4
Delta time in closed arm before/after self-admin	2.6	2.5	3.4	1.8	1.7	-1.0
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.3	0.1	-0.3
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	-0.2	0.7	-0.2
Extinction: sum of active levers before priming	0.8	0.8	1.6	0.8	1.3	0.1
Active lever presses in extinction session 6	4.1	3.9	6.0	-2.0	-1.4	2.5
Delta distance traveled before/after self-admin	1.5	1.6	2.1	1.4	1.4	-0.9
Delta ambulatory time before/after self-admin	0.8	0.9	1.9	0.9	1.4	-0.1
Time in closed arm before self-admin	0.1	0.2	0.3	-0.6	-0.2	-0.3
Time in closed arm after self-admin	1.9	2.0	3.1	1.3	1.0	-1.8
Time in open arm before self-admin	0.6	0.6	1.0	1.0	0.9	-0.4
Time in open arm after self-admin	0.2	0.2	0.4	0.6	0.4	-0.4
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.8	-0.6	-0.8	0.9
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.3	-0.2	0.2
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.0	-0.6	-0.2	1.0
Time to tail flick, test, before self-admin	0.5	0.5	0.8	0.9	0.8	-0.4
Time to tail flick, test, after self-admin	0.3	0.3	0.5	-0.6	-0.1	0.7
Delta time to tail flick, vehicle, before/after SA	1.6	1.6	3.1	-1.2	-0.5	1.8
Delta time to tail flick, test, before/after SA	1.4	1.3	2.0	-1.4	-1.0	0.9
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	0.1	-0.3
Ambulatory time after self-admin	2.0	2.2	4.8	1.2	2.2	-0.4
Total heroin consumption	3.5	4.2	5.2	-2.3	-1.9	2.0
Area under the delay curve	0.1	0.1	0.2	-0.2	-0.4	0.3
Delay disc. indifference point, 0s delay	0.6	0.6	1.0	-1.0	-0.7	0.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.5	0.5	-0.3	-0.7
Delay disc. indifference point, 2s delay	1.6	1.8	2.5	-1.4	-1.0	1.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	0.4	-0.3
Delay disc. indifference point, 4s delay	0.7	0.7	1.0	-0.7	-1.0	0.7
Delay disc. indifference point, 8s delay	0.2	0.2	0.2	-0.4	-0.4	0.4
Delay discount exponential model param	0.0	0.0	0.1	0.1	0.3	-0.1
Delay discount hyperbolic model param	0.1	0.1	0.1	0.2	0.4	-0.3
Fecal boli incidents, locomotor time 1	0.2	0.2	0.5	0.3	0.7	0.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.1	0.2	-0.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.0	-0.1	-0.3
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.4	0.4	0.1
Total resting periods, locomotor time 1	0.3	0.3	0.5	0.6	0.7	0.1
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.6	-0.2	0.7
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.2	-0.1	-0.1
Vertical activity count, locomotor time 1	0.2	0.2	0.2	0.5	0.4	-0.4
Time >=10cm from walls, locomotor time 2	1.4	1.5	1.7	-1.3	-1.2	1.2
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.2	-0.4	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.0	-0.3	-0.5
Rest time, locomotor task time 2	0.4	0.4	0.7	0.7	0.8	-0.4
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.3	0.4	0.3
Vertical activity count, locomotor time 2	0.3	0.4	0.6	0.6	0.8	-0.3
Weight adjusted by age	0.4	0.5	1.1	-0.2	0.6	1.0
Seeking ratio, delayed vs. immediate footshock	0.9	1.0	2.3	0.6	-0.6	-1.5
Locomotion in novel chamber	4.0	4.9	5.5	-2.3	-2.3	2.0
Locomotion in novel chamber post-restriction	2.1	2.5	3.2	-1.8	-1.1	1.7
Progressive ratio	0.3	0.3	0.6	-0.7	-0.1	0.8
Food seeking constrained by brief footshock	0.5	0.6	0.8	-0.8	-0.5	0.9
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.2	-0.1	-0.1
Run reversals in cocaine runway, females	5.2	5.1	7.9	2.4	1.3	-2.8
Run reversals in cocaine runway, males	0.3	0.3	0.6	-0.4	-0.8	0.5
Latency to leave start box in cocaine runway	1.6	1.8	2.2	1.5	1.1	-1.4
Latency to leave start box in cocaine runway, F	1.2	1.4	2.0	1.4	1.1	-0.9
Latency to leave start box in cocaine runway, M	0.5	0.5	1.3	0.1	-0.4	-1.1
Cd content in liver	0.1	0.1	0.3	-0.2	-0.6	0.1
Co content in liver	1.0	1.1	1.5	1.2	0.7	-1.1
Cu content in liver	0.4	0.5	1.2	0.5	-0.3	-1.1
Fe content in liver	0.5	0.6	1.1	0.8	1.1	-0.2
K content in liver	1.0	1.0	1.4	-1.1	-1.2	0.7
Mg content in liver	0.5	0.5	1.2	-0.3	-1.1	-0.5
Mn content in liver	1.4	1.6	3.3	-1.3	-1.8	-0.1
Na content in liver	1.2	1.2	2.3	-1.0	-0.6	1.5
Rb content in liver	0.8	0.9	1.6	-1.0	-1.3	0.4
Se content in liver	3.3	4.0	7.4	-2.0	-2.7	0.8
Sr content in liver	0.4	0.4	1.0	0.1	-0.3	-1.0
Zn content in liver	2.4	2.6	4.5	-1.7	-2.1	0.7