Med1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000005606	0.05	0.04	2.0e-04	0.03	0.03	0.02	0.02	6.8e-04	6.3e-04	1.1e-03	1.1e-03
2	Liver	gene expression	ENSRNOG00000005606	0.03	0.03	9.9e-04	0.02	0	0	0.01	2.0e-03	2.1e-01	9.6e-02	7.3e-03
3	Liver	intron excision ratio	chr10:83174436:83175382	0.02	0.02	3.9e-03	0.02	0.02	0	0.02	2.7e-03	4.2e-03	1.9e-01	1.6e-03
4	OFC	isoform ratio	ENSRNOT00000114652	0.84	0.11	6.9e-03	-0	-0	0.03	-0.01	3.8e-01	3.9e-01	5.7e-02	5.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4
BMI with tail	1.6	5.3	7.5	-1.8	2.4	-2.7	-2.1
BMI without tail	0.1	0.1	0.2	-0.4	0.2	-0.5	0.2
Body weight	4.4	18.4	24.1	-4.5	4.9	-4.5	-3.0
Epididymis fat weight	0.1	0.2	0.6	-0.8	0.4	-0.2	-0.1
Glucose	0.4	0.5	1.7	1.3	-0.6	0.2	-0.1
Heart weight	2.2	3.2	4.1	-2.0	1.8	-2.0	-1.1
Left kidney weight	1.2	3.6	7.8	-2.8	1.8	-1.8	-0.3
Right kidney weight	0.2	0.6	1.3	-1.1	0.8	-0.6	-0.2
Tail length	0.5	1.4	3.5	-1.9	0.9	-0.7	0.9
Length with tail	2.7	9.8	17.2	-4.1	3.5	-3.0	-1.0
Length without tail	3.3	7.3	10.1	-3.0	3.2	-2.6	-1.9
Liver weight, left	0.1	0.1	0.3	-0.4	-0.1	0.1	0.6
Liver weight, right	0.6	1.0	2.2	0.1	-0.9	1.0	1.5
Parametrial fat weight	1.7	3.3	5.0	0.9	-1.7	2.2	2.2
Retroperitoneal fat weight	0.0	0.1	0.3	-0.5	0.1	-0.3	0.2
Intraocular pressure	2.3	3.2	4.0	-1.3	1.9	-2.0	-1.9
Extensor digitorum longus weight	8.1	32.4	40.0	-5.5	6.1	-6.3	-4.8
Soleus weight	0.4	1.3	2.6	1.6	-0.0	-0.3	-1.6
Tibialis anterior weight	1.2	4.3	5.2	-1.8	2.3	-2.3	-1.9
Tibia length	1.5	4.4	7.8	-0.9	2.1	-2.1	-2.8
Number of licking bursts	0.4	0.4	1.2	1.1	-0.3	0.4	-0.5
Food consumed during 24 hour testing period	0.7	0.8	1.4	-0.9	1.2	-0.8	-0.6
Times rat made contact with spout	0.9	1.1	1.4	1.2	-1.1	1.2	0.5
Mean time between licks in bursts	1.1	1.5	1.9	-1.3	1.4	-1.3	-1.0
Mean num. licks in bursts	0.3	0.3	0.7	-0.1	-0.5	0.5	0.8
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.4	0.2	-0.2	0.0
Water consumed over 24 hours	0.2	0.2	0.7	0.1	0.4	-0.1	-0.9
Indifference point 0 sec	1.6	2.6	3.8	1.2	-1.7	1.6	1.9
Indifference point AUC	0.1	0.1	0.2	0.0	-0.1	-0.4	-0.2
Indifference point function ln k	0.0	0.0	0.1	-0.2	0.3	0.0	-0.2
Indifference point function log k	0.0	0.0	0.1	-0.2	0.3	0.0	-0.2
Delay discounting total patch changes 0 sec	1.2	1.9	3.0	0.9	-1.5	1.3	1.7
Delay discounting total patch changes 12 sec	5.4	7.1	9.1	2.4	-3.0	2.6	2.6
Delay discounting total patch changes 18 sec	0.3	0.4	0.8	0.7	-0.9	0.5	0.4
Delay discounting total patch changes 24 sec	1.2	1.6	2.6	1.6	-1.4	1.1	0.6
Delay discounting total patch changes 6 sec	2.3	3.5	4.6	1.4	-2.1	1.7	2.1
Delay discounting time to switch 0 sec	0.1	0.2	0.4	0.2	-0.4	0.4	0.6
Delay discounting water rate 0 sec	0.1	0.1	0.4	-0.2	-0.3	0.2	0.6
Delay discounting water rate 12 sec	0.2	0.3	0.5	-0.7	0.7	0.0	-0.4
Delay discounting water rate 18 sec	0.4	0.6	1.0	0.8	-0.6	1.0	0.5
Delay discounting water rate 24 sec	0.7	0.9	1.4	0.5	-1.0	1.2	1.0
Delay discounting water rate 6 sec	1.4	2.0	2.6	1.0	-1.5	1.6	1.5
Locomotor activity	0.4	0.6	1.5	1.2	-0.6	0.8	-0.2
Locomotor testing distance	1.6	2.7	4.8	2.2	-1.7	1.7	0.3
Locomotor testing rearing	4.8	7.5	9.8	2.5	-3.1	2.9	2.3
Light reinforcement 1	2.6	4.7	6.4	1.6	-2.5	2.3	2.2
Light reinforcement 2	0.9	1.2	2.0	1.1	-1.4	0.9	0.9
Reaction time number correct	0.4	0.6	1.1	-0.6	1.1	-0.9	-0.4
Reaction time mean minus median	0.3	0.4	0.9	-0.3	0.6	-0.5	-1.0
Reaction time mean minus median AUC	0.2	0.3	1.0	0.5	0.0	-0.1	-1.0
Reaction time num false alarms	0.6	0.8	1.5	1.2	-1.0	0.8	0.3
Reaction time num false alarms AUC	0.4	0.6	1.3	1.1	-0.9	0.7	0.2
Reaction time trials correct on left	0.4	0.6	1.1	-0.6	1.1	-0.9	-0.4
Reaction time trials on left	0.4	0.6	1.1	-0.6	1.0	-0.9	-0.4
Reaction time mean	0.1	0.1	0.5	-0.2	-0.1	0.7	-0.1
Reaction time mean AUC	0.1	0.1	0.5	-0.3	-0.2	0.7	-0.1
Median of all reaction times	0.5	0.7	1.9	0.3	-0.8	1.4	0.4
Reaction time omissions	0.9	1.3	1.9	1.0	-1.2	1.4	0.9
Reaction time false alarm rate	0.8	1.1	1.7	1.3	-1.3	1.0	0.3
Reaction time premature initiation rate	0.2	0.3	0.9	0.6	-0.2	0.9	-0.1
Reaction time premature initiations	0.1	0.2	0.4	-0.0	0.6	0.2	-0.4
Std. dev. reaction times	0.1	0.1	0.4	-0.0	0.2	0.1	-0.6
Reaction time trials completed	0.4	0.6	1.1	-0.6	1.0	-0.9	-0.4
Reaction time trials AUC	0.4	0.5	1.0	-0.5	1.0	-0.9	-0.4
Social response proportion	0.6	0.6	1.7	0.1	0.5	-0.8	-1.3
Social responses	0.1	0.1	0.3	0.5	-0.5	0.1	0.1
Social time	0.1	0.1	0.4	0.3	0.2	-0.1	-0.6
Conditioned locomotion	0.1	0.1	0.3	0.1	-0.3	0.2	0.5
Cocaine response after cond. corrected	1.3	1.5	4.4	2.1	-1.1	0.7	-0.2
Cocaine response after cond. not corrected	2.1	2.3	6.6	2.6	-1.2	0.8	-0.6
Cocaine response before conditioning	0.5	0.6	1.1	1.0	-0.4	0.3	-1.1
Saline control response	0.6	0.9	2.2	0.9	0.3	-0.5	-1.5
Condit. Reinf. active minus inactive responses	0.9	1.1	1.8	0.8	-1.0	1.4	0.9
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.5	0.6	-0.9	1.2	1.2
Condit. Reinf. active responses	1.3	1.9	3.2	1.2	-1.3	1.8	1.1
Condit. Reinf. inactive responses	1.6	2.0	2.9	1.7	-1.4	1.6	0.6
Condit. Reinf. lever presses	0.0	0.0	0.1	0.1	-0.1	0.4	0.1
Condit. Reinf. lever reinforcers received	1.5	2.1	3.2	1.1	-1.4	1.8	1.4
Pavlov. Cond. lever latency	0.3	0.4	0.6	-0.6	0.6	-0.8	-0.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.2	0.1	-0.3	-0.4
Pavlov. Cond. change in total contacts	0.7	0.9	1.1	0.7	-1.0	1.0	1.1
Pavlov. Cond. index score	0.2	0.3	0.5	0.7	-0.6	0.5	0.2
Pavlov. Cond. latency score	0.1	0.2	0.3	0.6	-0.4	0.3	0.1
Pavlov. Cond. lever contacts	0.7	1.0	1.5	1.2	-1.0	1.1	0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.6	0.3	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	1.9	2.5	3.2	-1.8	1.8	-1.4	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.5	-0.4	0.4	0.2
Pavlov. Cond. response bias	1.1	1.6	1.9	1.3	-1.4	1.3	0.9
Conditioned reinforcement - actives	0.6	0.6	1.2	1.1	-0.5	0.9	0.1
Conditioned reinforcement - inactives	2.1	2.4	3.5	0.8	-1.5	1.8	1.9
Conditioned locomotion	0.5	0.5	1.6	1.2	-0.6	0.6	0.1
Intermittent access intake day 1-15 change	0.4	0.4	0.9	0.1	-0.5	0.9	0.6
Intermittent access intake escalation	0.5	0.5	0.9	0.0	-0.5	0.9	0.9
Intermittent access intake escalation 2	0.1	0.1	0.1	-0.3	0.0	0.2	0.2
Intermitt. access day 1 inactive lever presses	2.8	3.0	5.4	0.6	-1.8	1.7	2.3
Intermitt. access day 15 inactive lever presses	4.2	4.6	5.8	1.6	-2.4	2.2	2.3
Intermitt. access escalation Index	2.9	2.6	4.4	-0.7	1.9	-1.4	-2.1
Intermittent access day 1 total infusions	0.2	0.3	0.5	0.4	-0.3	0.5	0.7
Intermittent access day 15 total infusions	0.7	0.8	1.4	0.3	-0.7	1.0	1.2
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.5	0.4	-0.8	1.1	1.2
Intermittent access total infusions	0.3	0.3	0.8	0.1	-0.3	0.6	0.9
Intermittent access day 1 locomotion	0.3	0.3	0.4	0.6	-0.6	0.4	0.6
Intermittent access day 15 total locomotion	0.3	0.4	0.6	0.8	-0.6	0.6	0.3
Intermittent access total locomotion	0.6	0.7	0.8	0.7	-0.9	0.9	0.8
Intermittent access standard deviation	2.1	2.2	4.1	0.1	-1.2	1.8	2.0
Cocaine induced anxiety	1.7	2.0	3.0	-1.3	1.7	-1.4	-1.1
Post-drug Anxiety	0.2	0.2	0.4	0.0	0.6	-0.4	-0.6
Baseline Anxiety	1.5	1.5	2.8	1.7	-1.4	1.1	0.6
Lifetime Intake	0.4	0.4	1.0	-0.0	-0.4	0.7	1.0
Incentive Sensitization - Responses	1.3	1.3	2.1	1.0	-1.2	1.5	0.9
Incentive Sensitization - Breakpoint	1.3	1.3	2.0	1.1	-1.1	1.4	0.8
Progressive ratio test 1 active lever presses	0.5	0.5	1.2	1.1	-0.6	0.6	0.0
Progressive ratio test 1 breakpoint	0.4	0.4	1.1	1.1	-0.5	0.6	-0.0
Progressive ratio test 1 inactive lever presses	1.3	1.4	2.0	0.6	-1.2	1.4	1.3
Progressive ratio test 2 active lever presses	1.1	1.1	1.8	1.0	-1.0	1.4	0.9
Progressive ratio test 2 breakpoint	0.7	0.8	1.3	1.0	-0.8	1.2	0.5
Progressive ratio test 2 inactive lever presses	0.8	1.0	2.1	0.1	-0.8	1.0	1.5
Total sessions with >9 infusions	0.5	0.6	0.7	0.7	-0.9	0.8	0.6
Short access day 1 total inactive lever presses	3.2	3.5	5.8	1.0	-2.0	1.8	2.4
Short access day 10 total inactive lever presses	0.4	0.5	1.0	-0.9	0.2	0.0	1.0
Short access day 1 total infusions	1.0	1.0	2.0	0.1	-1.1	1.0	1.4
Short access day 10 total infusions	0.3	0.4	0.5	0.5	-0.6	0.7	0.7
Short access total infusions	0.5	0.5	1.1	-0.1	-0.5	0.8	1.1
Short access day 1 locomotion	3.8	4.0	5.2	1.3	-2.3	2.1	2.2
Short access day 10 total locomotion	1.4	1.5	2.0	1.4	-1.3	1.1	1.1
Short access total locomotion	0.6	0.6	1.1	0.4	-0.9	0.7	1.0
Compulsive drug intake	0.4	0.4	0.6	-0.5	0.8	-0.5	-0.7
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.0	0.3	0.1	-0.2
One hour access (shock baseline)	0.3	0.4	0.5	0.4	-0.5	0.7	0.7
Number of responses in last shaping day	1.2	1.2	2.7	-0.3	-1.1	0.9	1.7
Context. condit. distance diff. score	1.3	1.6	2.0	-0.9	1.4	-1.3	-1.4
Locomotion velocity, session 1	0.3	0.3	0.6	-0.8	0.4	-0.6	0.2
Locomotion distance, session 1	1.6	2.1	3.8	-1.9	1.4	-1.7	0.1
Locomotion velocity, session 2	0.3	0.4	1.0	-1.0	0.2	-0.4	0.7
Locomotion distance, session 2	0.4	0.6	1.4	-0.9	0.1	-0.3	1.2
Locomotion velocity, session 3	0.3	0.3	0.7	-0.7	-0.2	0.1	0.8
Locomotion distance, session 3	0.3	0.3	0.6	-0.8	0.3	-0.6	0.3
Stereotopy head waving bouts, day 3	2.1	2.5	3.3	1.8	-1.7	1.8	0.8
Stereotopy head waving duration, day 3	0.2	0.3	0.5	0.7	-0.2	0.4	-0.6
Locomotion velocity, session 7	0.7	0.8	1.4	-0.7	0.9	-1.2	-0.7
Locomotion distance, session 7	0.3	0.3	0.7	-0.2	0.5	-0.8	-0.6
Stereotopy head waving bouts, day 7	0.4	0.5	1.1	1.1	-0.5	0.7	-0.0
Stereotopy head waving duration, day 7	0.2	0.2	0.2	0.5	-0.4	0.5	0.3
Locomotion velocity, session 8	6.6	7.9	9.6	-2.8	3.1	-3.1	-2.2
Locomotion distance, session 8	1.0	1.4	1.9	-1.4	1.4	-1.3	-0.4
Degree of sensitization distance	1.0	1.0	1.8	-0.4	1.1	-1.0	-1.3
Degree of sensitization stereotypy	0.8	0.9	2.1	1.4	-0.7	0.9	-0.0
Condit. Reinf. active minus inactive responses	0.8	0.9	1.4	0.4	-1.1	1.0	1.2
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.1	0.4	-0.9	1.1	1.0
Condit. Reinf. active responses	0.7	0.9	1.3	0.7	-1.1	1.1	0.8
Condit. Reinf. inactive responses	0.3	0.4	1.0	1.0	-0.5	0.3	-0.6
Incentive salience index mean	1.9	2.3	3.2	1.0	-1.8	1.6	1.5
Condit. Reinf. lever presses	1.2	1.6	2.4	1.2	-1.5	1.2	1.0
Time in familiar zone, hab. session 1	0.7	0.6	1.2	1.1	-0.9	0.7	0.1
Time in novel zone, hab. session 1	0.3	0.2	0.3	0.4	-0.5	0.6	0.5
Total zone transitions, hab. session 1	1.4	1.9	3.2	-1.8	1.5	-1.4	-0.7
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.3	0.0	0.2	0.1
Locomotion velocity, hab. session 1	0.3	0.5	1.1	-1.0	0.8	-0.4	-0.2
Time in familiar zone, hab. session 2	0.8	0.8	1.0	0.8	-1.0	0.9	0.9
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	-0.2	0.3	0.2
Total zone transitions, hab. session 2	0.6	0.8	1.2	-0.7	0.9	-1.1	-0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.2	0.4	-0.3	-0.4
Locomotion velocity, hab. session 2	0.2	0.3	0.4	-0.4	0.6	-0.6	-0.6
Novel to familiar place preference ratio	1.2	1.3	1.9	-1.4	1.2	-1.2	-0.6
Novelty place preference	1.1	1.1	1.4	-1.2	1.1	-1.2	-0.8
Time in novel zone, NPP test	0.4	0.5	0.6	-0.7	0.7	-0.7	-0.6
Total zone transitions, NPP test	0.2	0.3	0.5	-0.3	0.6	-0.7	-0.3
Total locomotion distance, NPP test	0.0	0.0	0.1	0.3	-0.1	0.2	0.1
Locomotion velocity, NPP test	0.1	0.2	0.3	-0.4	0.5	-0.4	-0.2
Pavlov. Cond. lever latency	2.9	3.7	4.8	-2.1	2.2	-2.0	-1.2
Pavlov. Cond. magazine entry latency	9.1	11.7	14.2	3.7	-3.7	3.8	2.3
Pavlov. Cond. change in total contacts	8.0	8.5	11.0	2.7	-3.3	3.3	2.3
Pavlov. Cond. index score	7.7	9.8	12.0	3.5	-3.5	3.4	2.0
Pavlov. Cond. latency score	5.9	7.5	9.9	3.1	-3.0	2.9	1.6
Pavlov. Cond. lever contacts	2.4	2.9	4.1	2.0	-1.9	1.8	0.8
Pavlov. Cond. magazine entry number	11.4	14.2	17.3	-4.0	4.1	-4.2	-2.5
Pavlov. Cond. intertrial magazine entries	1.5	1.8	2.3	-1.5	1.4	-1.5	-0.8
Pavlov. Cond. lever-magazine prob. diff.	8.5	10.7	13.1	3.6	-3.6	3.5	2.1
Pavlov. Cond. response bias	8.5	10.4	13.0	3.4	-3.6	3.5	2.2
Bone: apparent density	1.8	3.1	4.0	1.9	-1.8	2.0	1.2
Bone surface	0.0	0.1	0.2	0.1	-0.2	0.2	0.5
Bone volume	0.2	0.3	0.4	0.6	-0.5	0.6	0.5
Bone: connectivity density	2.6	4.0	5.2	1.9	-2.1	2.3	1.6
Bone: cortical apparent density	5.6	7.3	8.9	2.4	-3.0	3.0	2.4
Bone: cortical area	0.1	0.1	0.4	0.7	-0.3	0.2	-0.2
Bone: cortical porosity	0.4	0.5	1.2	1.1	-0.5	0.3	-0.5
Bone: cortical porosity	0.7	0.8	1.7	1.3	-0.4	0.2	-1.1
Bone: cortical thickness	0.8	1.3	2.5	1.6	-1.2	1.2	0.3
Bone: cortical thickness	3.9	4.5	6.8	2.2	-2.3	2.6	1.0
Bone: cortical tissue density	5.6	7.3	9.0	2.4	-3.0	3.0	2.4
Bone: elastic displacement	0.0	0.0	0.1	0.1	0.1	0.1	-0.3
Bone: elastic work	0.1	0.1	0.2	0.1	-0.2	0.4	0.4
Bone: endosteal estimation	1.6	3.5	4.6	-1.8	2.1	-2.2	-1.3
Bone: endosteal perimeter	1.0	2.0	3.2	-1.8	1.5	-1.6	-0.5
Bone: final force	0.7	1.2	3.1	1.8	-0.9	0.8	-0.1
Bone: final moment	0.6	0.9	2.7	1.6	-0.8	0.6	-0.3
Bone: marrow area	1.5	3.3	4.3	-1.7	2.0	-2.1	-1.3
Bone: maximum diameter	0.0	0.0	0.1	0.2	-0.3	0.2	0.1
Bone: maximum force	0.1	0.2	0.3	0.6	0.1	-0.2	-0.6
Bone: maximum moment	0.1	0.2	0.5	0.4	0.2	-0.4	-0.7
Bone: minimum diameter	0.3	0.6	1.0	-0.7	0.8	-1.0	-0.5
Bone: periosteal estimation	0.2	0.4	0.5	-0.3	0.7	-0.7	-0.6
Bone: periosteal perimeter	0.4	0.7	1.0	-0.7	0.9	-1.0	-0.8
Bone: post-yield work	1.4	1.9	2.4	-1.1	1.4	-1.6	-1.3
Bone: stiffness	0.1	0.1	0.3	0.5	-0.0	-0.2	-0.4
Bone: tissue strength	1.0	1.0	1.4	-0.5	1.0	-1.1	-1.2
Bone: trabecular number	4.3	6.7	8.4	2.8	-2.7	2.9	1.7
Bone: trabecular spacing	1.0	1.3	1.8	-0.7	1.2	-1.3	-1.2
Bone: trabecular thickness	0.1	0.2	0.3	0.1	-0.4	0.6	0.3
Bone: trabecular tissue density	0.0	0.1	0.1	-0.4	0.2	-0.2	-0.0
Breakpoint value in progressive ratio session	0.8	0.9	1.9	-1.2	0.2	0.4	1.4
Distance traveled before self-admin	0.0	0.0	0.1	-0.3	0.0	0.0	0.1
Distance traveled after self-admin	1.0	1.1	1.9	-1.4	1.2	-1.1	-0.4
Delta time in closed arm before/after self-admin	3.6	3.5	3.9	-1.8	1.9	-2.0	-1.8
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.3	-0.0	0.2	0.0
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	-0.7	0.6	0.1	-0.3
Extinction: sum of active levers before priming	1.8	1.9	2.7	-0.8	1.5	-1.4	-1.6
Active lever presses in extinction session 6	1.7	1.6	2.8	0.9	-1.3	1.1	1.7
Delta distance traveled before/after self-admin	1.3	1.4	1.7	-1.2	1.3	-1.3	-0.8
Delta ambulatory time before/after self-admin	1.1	1.2	1.7	-0.6	1.2	-1.3	-1.1
Time in closed arm before self-admin	1.0	1.1	1.7	0.8	-1.3	1.0	1.0
Time in closed arm after self-admin	0.6	0.6	1.2	-1.1	0.7	-0.7	-0.5
Time in open arm before self-admin	1.7	1.8	2.9	-1.7	1.5	-1.3	-0.6
Time in open arm after self-admin	0.3	0.3	0.4	-0.7	0.7	-0.5	-0.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.6	0.7	-0.8	0.6	0.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.6	-0.2	0.2	-0.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.5	-0.3	0.1	0.0
Time to tail flick, test, before self-admin	1.9	1.8	2.6	-0.8	1.6	-1.2	-1.6
Time to tail flick, test, after self-admin	0.4	0.4	0.6	0.6	-0.8	0.4	0.7
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	0.8	-0.4	0.4	-0.1
Delta time to tail flick, test, before/after SA	3.7	3.3	4.9	1.6	-2.2	1.6	1.8
Ambulatory time before self-admin	0.1	0.1	0.4	-0.6	0.1	0.0	0.2
Ambulatory time after self-admin	1.9	2.0	3.1	-1.8	1.6	-1.5	-0.6
Total heroin consumption	1.9	2.3	4.1	0.9	-1.3	2.0	1.6
Area under the delay curve	0.3	0.3	0.8	0.9	-0.5	0.3	-0.1
Delay disc. indifference point, 0s delay	1.2	1.3	1.7	1.2	-1.0	1.3	1.1
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	0.6	-0.9	0.3	0.1
Delay disc. indifference point, 2s delay	1.3	1.5	3.7	1.9	-1.1	1.0	0.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	0.2	0.2	-0.4	-0.7
Delay disc. indifference point, 4s delay	0.7	0.7	1.0	1.0	-0.8	0.8	0.8
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	0.7	-0.1	0.0	-0.4
Delay discount exponential model param	0.1	0.1	0.4	-0.7	0.3	-0.1	0.2
Delay discount hyperbolic model param	0.2	0.3	0.7	-0.9	0.5	-0.3	0.0
Fecal boli incidents, locomotor time 1	0.2	0.2	0.5	-0.3	0.1	-0.7	-0.6
Change in fecal boli incidents, locomotor task	0.2	0.1	0.3	0.4	0.3	-0.2	-0.6
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	0.7	-0.7	0.2	0.3
Bouts of movement, locomotor time 1	1.1	1.3	1.8	-0.9	1.2	-1.0	-1.3
Total resting periods, locomotor time 1	1.9	2.1	3.3	-0.9	1.5	-1.4	-1.8
Rest time, locomotor task time 1	0.1	0.1	0.5	-0.1	0.2	0.0	-0.7
Distance moved, locomotor task time 1	0.3	0.4	0.5	0.7	-0.7	0.4	0.7
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.2	0.0	-0.3	0.1
Time >=10cm from walls, locomotor time 2	1.2	1.2	2.6	1.6	-1.0	0.9	0.5
Bouts of movement, locomotor time 2	0.1	0.1	0.1	-0.2	-0.3	0.2	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.5	-0.1	0.1	0.2
Rest time, locomotor task time 2	0.9	1.0	1.4	-1.2	0.9	-0.9	-0.9
Distance moved, locomotor task time 2	0.2	0.2	0.4	0.4	-0.4	-0.1	0.7
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.1	0.4	-0.5	0.0
Weight adjusted by age	0.5	0.5	1.3	-0.2	0.7	-0.6	-1.2
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.9	-0.2	-0.8	0.6	1.0
Locomotion in novel chamber	6.0	7.4	10.5	2.8	-3.2	2.6	2.1
Locomotion in novel chamber post-restriction	1.2	1.5	1.7	1.3	-1.2	1.3	0.9
Progressive ratio	0.3	0.4	0.8	0.2	-0.7	0.2	0.9
Food seeking constrained by brief footshock	0.2	0.3	0.4	0.5	-0.4	0.5	0.7
Seeking ratio, punishment vs. effort	0.2	0.3	0.7	0.4	0.5	-0.0	-0.8
Run reversals in cocaine runway, females	2.4	2.4	3.7	-1.7	1.9	-1.3	-1.1
Run reversals in cocaine runway, males	0.5	0.5	0.8	0.9	-0.8	0.8	0.4
Latency to leave start box in cocaine runway	1.2	1.3	2.7	-1.6	1.1	-1.2	0.1
Latency to leave start box in cocaine runway, F	1.1	1.2	2.0	-1.4	1.2	-1.2	-0.2
Latency to leave start box in cocaine runway, M	1.2	1.1	3.4	-0.7	-0.7	0.4	1.8
Cd content in liver	0.1	0.1	0.2	0.3	-0.4	0.2	0.5
Co content in liver	0.6	0.7	2.0	-1.4	0.6	-0.6	0.1
Cu content in liver	0.8	1.0	2.5	-1.2	0.0	0.0	1.6
Fe content in liver	0.7	0.9	1.2	-1.1	1.0	-1.1	-0.4
K content in liver	1.2	1.2	2.4	0.6	-1.0	1.1	1.6
Mg content in liver	0.8	0.8	1.7	0.3	-0.8	0.9	1.3
Mn content in liver	2.1	2.5	4.9	0.5	-1.5	1.6	2.2
Na content in liver	0.2	0.2	0.6	0.8	-0.2	0.5	0.1
Rb content in liver	1.6	2.0	2.7	1.1	-1.5	1.4	1.7
Se content in liver	5.2	6.3	8.5	1.5	-2.7	2.8	2.9
Sr content in liver	0.5	0.4	1.2	-0.6	-0.3	0.3	1.1
Zn content in liver	3.3	3.6	5.1	1.2	-2.0	2.2	1.9