| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000023457 | 0.1100 | 0.0430 | 1.2e-14 | 0.072 | 0.110 | 0.109 | 0.108 | 2.0e-08 | 3.3e-12 | 4.0e-12 | 5.0e-12 |
| 2 | BLA | gene expression | ENSRNOG00000023457 | 0.1332 | 0.0661 | 3.8e-04 | -0.003 | 0.027 | 0.013 | 0.007 | 5.0e-01 | 1.3e-02 | 6.1e-02 | 1.3e-01 |
| 3 | Brain | gene expression | ENSRNOG00000023457 | 0.1100 | 0.0620 | 3.8e-07 | 0.026 | 0.076 | 0.061 | 0.045 | 1.7e-03 | 1.5e-07 | 2.7e-06 | 4.7e-05 |
| 4 | LHb | gene expression | ENSRNOG00000023457 | 0.2027 | 0.1022 | 1.5e-03 | 0.105 | 0.108 | 0.031 | 0.082 | 1.8e-03 | 1.6e-03 | 6.3e-02 | 5.5e-03 |
| 5 | NAcc | gene expression | ENSRNOG00000023457 | 0.1700 | 0.0680 | 4.4e-12 | 0.084 | 0.158 | 0.150 | 0.165 | 8.4e-07 | 7.5e-12 | 3.0e-11 | 2.5e-12 |
| 6 | OFC | alternative polyA | ENSRNOT00000029382 | 0.3430 | 0.1310 | 2.6e-03 | -0.001 | 0.013 | 0.076 | -0.001 | 3.3e-01 | 1.6e-01 | 7.4e-03 | 3.4e-01 |
| 7 | OFC | gene expression | ENSRNOG00000023457 | 0.2081 | 0.1064 | 1.8e-03 | 0.092 | 0.134 | 0.082 | 0.089 | 3.4e-03 | 4.6e-04 | 5.5e-03 | 3.9e-03 |
| 8 | PL | gene expression | ENSRNOG00000023457 | 0.0829 | 0.0388 | 3.2e-06 | 0.054 | 0.043 | 0.056 | 0.063 | 6.2e-05 | 3.2e-04 | 4.2e-05 | 1.5e-05 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tibialis anterior weight | 5.0 | 17.4 | 37.1 | 3.9 | 2.7 | 3.6 | 5.9 | 2.6 | 0.5 | 5.0 | 6.1 |
| Extinction: sum of active levers before priming | 4.3 | 4.4 | 7.4 | 2.7 | 2.1 | 1.6 | 2.3 | 2.1 | -0.4 | 1.9 | 2.7 |
| Extensor digitorum longus weight | 4.1 | 16.4 | 36.8 | 3.5 | 2.3 | 3.1 | 5.8 | 2.6 | 0.6 | 5.1 | 6.1 |
| Time in open arm before self-admin | 3.9 | 4.2 | 6.5 | 2.3 | 1.9 | 2.3 | 2.6 | 1.8 | -0.2 | 1.9 | 2.4 |
| Time to tail flick, test, before self-admin | 3.8 | 3.7 | 6.1 | -2.2 | -2.5 | -1.7 | -2.1 | -2.4 | 0.6 | -1.5 | -1.9 |
| Condit. Reinf. active-inactive response ratio | 3.6 | 3.9 | 9.8 | 2.2 | 2.1 | 1.0 | 1.9 | 3.1 | 0.1 | 2.3 | 1.5 |
| BMI without tail | 3.5 | 7.3 | 12.8 | 2.8 | 2.3 | 1.6 | 3.4 | 2.7 | 0.5 | 3.2 | 3.6 |
| Bone: elastic work | 3.5 | 4.5 | 8.0 | 2.3 | 2.7 | 1.4 | 2.5 | 2.2 | -0.5 | 1.6 | 2.8 |
| Progressive ratio test 2 breakpoint | 3.0 | 3.3 | 5.1 | 2.2 | 1.6 | 1.5 | 2.1 | 1.9 | 0.3 | 2.0 | 2.3 |
| Condit. Reinf. inactive responses | 3.0 | 3.6 | 6.6 | -2.2 | -2.3 | -1.3 | -1.9 | -2.6 | -0.1 | -1.7 | -2.0 |
| Zn content in liver | 2.9 | 3.2 | 8.0 | -1.0 | -0.7 | -1.5 | -2.8 | -0.6 | 0.4 | -2.3 | -2.8 |
| BMI with tail | 2.8 | 9.0 | 12.5 | 3.5 | 2.6 | 2.5 | 3.2 | 3.3 | 1.5 | 3.3 | 3.4 |
| Bone: tissue strength | 2.8 | 2.7 | 6.3 | 1.8 | 2.5 | 1.0 | 1.4 | 2.3 | -0.7 | 1.0 | 1.4 |
| Body weight | 2.6 | 10.9 | 18.3 | 3.6 | 2.0 | 2.6 | 4.0 | 3.3 | 1.8 | 4.3 | 3.8 |
| Conditioned locomotion | 2.5 | 3.0 | 5.4 | -1.8 | -1.9 | -2.0 | -2.2 | -1.0 | 0.7 | -1.3 | -2.3 |
| Delay discounting water rate 6 sec | 2.4 | 3.4 | 7.3 | 2.4 | 1.8 | 1.4 | 1.5 | 2.7 | 1.0 | 1.9 | 1.5 |
| Progressive ratio test 2 active lever presses | 2.4 | 2.5 | 3.9 | 1.9 | 1.5 | 1.2 | 1.8 | 1.7 | 0.1 | 1.7 | 2.0 |
| Conditioned locomotion | 2.3 | 2.7 | 5.3 | -1.8 | -1.0 | -1.6 | -1.4 | -2.3 | -1.5 | -2.1 | -1.0 |
| Bone: cortical thickness | 2.3 | 3.8 | 7.3 | 2.0 | 2.1 | 1.1 | 2.5 | 2.0 | -0.3 | 1.9 | 2.7 |
| Saline control response | 2.2 | 2.9 | 7.2 | -1.9 | -2.7 | -0.3 | -1.5 | -1.4 | 1.6 | -0.5 | -2.3 |
| Short access day 10 total inactive lever presses | 2.2 | 2.4 | 4.7 | -1.7 | -1.9 | -0.1 | -1.7 | -1.7 | 0.5 | -1.3 | -2.2 |
| Bone: cortical area | 2.2 | 3.4 | 6.3 | 1.8 | 2.3 | 0.8 | 2.2 | 1.9 | -0.8 | 1.5 | 2.5 |
| Baseline Anxiety | 2.0 | 2.1 | 3.8 | 2.0 | 0.7 | 1.7 | 1.2 | 1.3 | 1.5 | 1.5 | 1.5 |
| Number of licking bursts | 1.9 | 2.2 | 6.8 | 1.5 | 2.4 | 0.4 | 0.9 | 2.6 | -0.9 | 0.7 | 0.9 |
| Distance moved, locomotor task time 1 | 1.9 | 2.1 | 4.2 | 1.3 | 0.2 | 2.0 | 1.2 | 1.3 | 2.0 | 1.7 | 0.9 |
| Delay discounting water rate 18 sec | 1.8 | 2.4 | 7.0 | 1.8 | 2.7 | 0.3 | 1.0 | 2.3 | -1.3 | 0.4 | 0.8 |
| Intermitt. access day 1 inactive lever presses | 1.8 | 2.0 | 3.8 | -1.0 | -2.0 | 0.1 | -1.6 | -1.3 | 1.9 | -0.9 | -1.6 |
| Intermittent access total infusions | 1.7 | 1.8 | 4.1 | 1.8 | 1.1 | 0.8 | 1.1 | 2.0 | 0.6 | 1.6 | 1.3 |
| Intermittent access day 15 total locomotion | 1.7 | 1.8 | 7.6 | -0.2 | 1.2 | -1.8 | -0.4 | -0.1 | -2.7 | -1.2 | 0.2 |
| Pavlov. Cond. change in total contacts | 1.7 | 1.8 | 3.5 | -1.2 | -0.7 | -1.9 | -1.6 | -0.8 | -0.8 | -1.4 | -1.7 |
| Bone: minimum diameter | 1.7 | 3.1 | 5.5 | 1.7 | 1.5 | 1.1 | 2.2 | 1.8 | 0.1 | 2.1 | 2.3 |
| Bone: post-yield work | 1.7 | 2.3 | 4.4 | -1.5 | -0.2 | -1.7 | -1.8 | -0.8 | -1.2 | -2.1 | -1.9 |
| Progressive ratio | 1.7 | 2.0 | 3.6 | 0.8 | -0.2 | 1.9 | 1.7 | 0.2 | 1.8 | 1.6 | 1.8 |
| Food seeking constrained by brief footshock | 1.7 | 2.1 | 4.0 | 1.6 | 2.0 | 0.5 | 1.4 | 1.7 | -0.9 | 1.0 | 1.7 |
| Ambulatory time before self-admin | 1.6 | 1.6 | 5.3 | -1.4 | -0.6 | -2.3 | -0.4 | -1.4 | -1.6 | -0.8 | -0.2 |
| Time >=10cm from walls, locomotor time 1 | 1.6 | 1.6 | 3.3 | 1.2 | 0.5 | 1.5 | 0.9 | 1.3 | 1.8 | 1.2 | 1.2 |
| Seeking ratio, delayed vs. immediate footshock | 1.6 | 1.9 | 3.5 | -1.3 | -1.8 | -0.6 | -1.4 | -1.9 | 0.5 | -1.3 | -1.4 |
| Fe content in liver | 1.6 | 1.9 | 4.1 | -1.4 | -1.6 | -0.8 | -1.6 | -1.4 | 0.6 | -1.1 | -2.0 |
| Liver weight, right | 1.5 | 2.5 | 9.5 | 0.4 | 2.5 | -1.1 | -0.1 | 0.8 | -3.1 | -1.5 | 0.2 |
| Retroperitoneal fat weight | 1.5 | 4.8 | 7.0 | 2.5 | 2.3 | 2.1 | 2.6 | 2.1 | -0.3 | 2.1 | 2.6 |
| Locomotor testing rearing | 1.5 | 2.4 | 5.4 | 2.1 | 0.7 | 2.3 | 0.2 | 1.8 | 2.2 | 0.9 | 0.0 |
| Condit. Reinf. active-inactive response ratio | 1.5 | 1.6 | 4.3 | 1.2 | 2.1 | 0.2 | 1.1 | 1.7 | -0.6 | 0.5 | 1.5 |
| Pavlov. Cond. intertrial magazine entries | 1.5 | 1.9 | 2.9 | 1.7 | 1.4 | 1.6 | 1.2 | 1.7 | 0.7 | 1.1 | 1.3 |
| Delay disc. indifference point, 24s delay | 1.5 | 1.5 | 3.0 | -1.2 | -1.4 | -0.7 | -1.3 | -1.7 | -0.2 | -1.3 | -1.2 |
| Total resting periods, locomotor time 2 | 1.5 | 1.6 | 2.4 | -1.3 | -1.1 | -1.1 | -1.5 | -1.4 | 0.0 | -1.4 | -1.4 |
| Indifference point AUC | 1.4 | 1.6 | 2.6 | 1.2 | 1.0 | 1.2 | 1.4 | 1.4 | 0.7 | 1.3 | 1.6 |
| Conditioned reinforcement - actives | 1.4 | 1.4 | 2.4 | -1.4 | -1.5 | -1.6 | -1.2 | -0.7 | 0.4 | -0.6 | -1.4 |
| Stereotopy head waving duration, day 7 | 1.4 | 1.7 | 3.2 | -1.8 | -0.9 | -1.5 | -0.8 | -1.6 | -1.3 | -1.3 | -0.9 |
| Pavlov. Cond. lever latency | 1.4 | 1.8 | 3.0 | 1.2 | -0.1 | 1.6 | 1.3 | 0.7 | 1.6 | 1.7 | 1.4 |
| Delta time to tail flick, test, before/after SA | 1.4 | 1.3 | 2.5 | 1.0 | 1.2 | 0.7 | 1.4 | 1.6 | -0.3 | 1.3 | 1.1 |
| Weight adjusted by age | 1.4 | 1.6 | 2.7 | -0.9 | -0.1 | -1.4 | -1.4 | -0.7 | -1.5 | -1.6 | -1.6 |
| Right kidney weight | 1.3 | 3.8 | 5.8 | 2.3 | 1.5 | 1.6 | 2.4 | 2.1 | 0.5 | 2.3 | 2.2 |
| Reaction time omissions | 1.3 | 1.8 | 4.8 | -1.3 | -0.3 | -1.3 | 0.0 | -2.1 | -2.2 | -1.1 | 0.6 |
| Conditioned reinforcement - inactives | 1.3 | 1.5 | 2.3 | -1.4 | -1.3 | -1.5 | -1.4 | -1.2 | -0.5 | -1.1 | -1.1 |
| Intermittent access intake day 1-15 change | 1.3 | 1.3 | 5.1 | -0.1 | 1.0 | -1.8 | -0.2 | -0.3 | -2.3 | -1.0 | 0.7 |
| Short access day 1 total infusions | 1.3 | 1.3 | 2.4 | -1.1 | -1.4 | -1.6 | -1.5 | -0.5 | 0.7 | -0.7 | -1.4 |
| Degree of sensitization stereotypy | 1.3 | 1.4 | 3.6 | -1.6 | -1.5 | -0.9 | -0.8 | -1.9 | -0.1 | -0.9 | -0.9 |
| Bone: elastic displacement | 1.3 | 1.4 | 2.8 | 1.0 | 1.6 | 0.1 | 1.4 | 1.1 | -1.1 | 0.8 | 1.7 |
| Delay disc. indifference point, 2s delay | 1.3 | 1.4 | 2.6 | -1.3 | -1.0 | -0.9 | -1.2 | -1.6 | -0.5 | -1.4 | -1.3 |
| Short access day 10 total locomotion | 1.2 | 1.3 | 4.1 | -0.9 | -0.2 | -2.0 | -1.5 | -0.3 | -0.4 | -1.4 | -1.1 |
| Stereotopy head waving duration, day 3 | 1.2 | 1.5 | 2.6 | 0.9 | 0.9 | 1.1 | 1.5 | 1.6 | 0.3 | 1.5 | 1.2 |
| Condit. Reinf. active minus inactive responses | 1.2 | 1.3 | 3.9 | 1.2 | 0.7 | 0.9 | 0.9 | 2.0 | 0.4 | 1.6 | 0.4 |
| Delay disc. indifference point, 8s delay | 1.2 | 1.2 | 4.2 | -0.8 | -2.0 | 0.4 | -0.7 | -1.3 | 1.3 | -0.0 | -0.9 |
| Bouts of movement, locomotor time 2 | 1.2 | 1.3 | 1.8 | -1.2 | -1.0 | -1.0 | -1.3 | -1.3 | 0.0 | -1.2 | -1.2 |
| Cu content in liver | 1.2 | 1.5 | 4.3 | -0.6 | -0.6 | -0.9 | -2.0 | -0.1 | 0.7 | -1.3 | -2.1 |
| Left kidney weight | 1.1 | 3.2 | 5.6 | 2.1 | 0.6 | 1.5 | 1.9 | 1.7 | 1.6 | 2.4 | 2.0 |
| Reaction time mean minus median | 1.1 | 1.4 | 2.5 | -1.5 | -0.7 | -1.3 | -0.6 | -1.6 | -1.5 | -1.1 | -0.6 |
| Reaction time mean minus median AUC | 1.1 | 1.4 | 2.2 | -1.4 | -0.9 | -1.3 | -1.0 | -1.5 | -1.2 | -1.2 | -1.1 |
| Std. dev. reaction times | 1.1 | 1.5 | 3.4 | -1.5 | -0.8 | -1.1 | -0.6 | -1.8 | -1.5 | -1.2 | -0.4 |
| Intermittent access intake escalation 2 | 1.1 | 1.1 | 3.1 | 0.6 | 1.4 | -1.0 | 0.5 | 0.4 | -1.8 | -0.2 | 1.3 |
| Short access day 1 locomotion | 1.1 | 1.1 | 2.4 | -0.7 | -1.1 | -1.2 | -1.4 | 0.3 | 1.3 | -0.2 | -1.5 |
| One hour access (0.3 mA shock) | 1.1 | 1.2 | 1.9 | 1.4 | 1.3 | 0.3 | 1.2 | 1.3 | -0.3 | 1.1 | 1.3 |
| Distance traveled before self-admin | 1.1 | 1.2 | 4.2 | -1.0 | -0.1 | -2.0 | -0.0 | -0.9 | -1.8 | -0.6 | 0.3 |
| Vertical activity count, locomotor time 1 | 1.1 | 1.2 | 3.4 | 0.8 | -0.1 | 1.5 | 0.8 | 0.8 | 1.8 | 1.3 | 0.4 |
| Sr content in liver | 1.1 | 1.0 | 3.4 | 0.4 | -1.0 | 1.4 | 0.6 | -0.5 | 1.8 | 0.8 | 0.7 |
| Water consumed over 24 hours | 1.0 | 1.2 | 2.1 | 1.2 | 1.4 | -0.0 | 1.1 | 1.1 | -1.0 | 0.7 | 1.5 |
| Light reinforcement 1 | 1.0 | 1.8 | 4.2 | 1.2 | -0.1 | 1.6 | 0.8 | 1.5 | 2.1 | 1.8 | 0.1 |
| Reaction time num false alarms | 1.0 | 1.4 | 2.2 | -1.5 | -0.8 | -1.1 | -1.0 | -1.1 | -1.3 | -1.1 | -1.3 |
| Intermittent access day 15 total infusions | 1.0 | 1.1 | 1.9 | 1.3 | 1.4 | 0.1 | 0.9 | 1.4 | -0.5 | 0.8 | 1.3 |
| Short access day 1 total inactive lever presses | 1.0 | 1.1 | 4.8 | -0.2 | -1.3 | 0.4 | -0.9 | -0.1 | 2.2 | -0.0 | -1.0 |
| Short access total locomotion | 1.0 | 1.0 | 2.1 | -0.7 | -0.6 | -1.4 | -1.4 | -0.2 | 0.2 | -1.0 | -1.3 |
| Locomotion velocity, session 7 | 1.0 | 1.1 | 2.8 | 1.2 | 1.7 | 0.3 | 0.8 | 1.4 | -1.0 | 0.5 | 1.0 |
| Mn content in liver | 1.0 | 1.1 | 2.0 | 1.0 | 1.2 | 1.0 | 1.3 | 0.7 | -0.6 | 0.8 | 1.4 |
| Tibia length | 0.9 | 2.7 | 4.9 | 1.5 | 0.8 | 2.1 | 2.2 | 0.8 | 0.8 | 1.7 | 2.2 |
| Delay discounting water rate 24 sec | 0.9 | 1.3 | 4.4 | 1.4 | 1.8 | 0.4 | 0.6 | 2.1 | -0.2 | 0.5 | 0.4 |
| Social time | 0.9 | 1.2 | 2.1 | -1.4 | -0.9 | -0.7 | -1.0 | -1.3 | -0.2 | -1.1 | -1.5 |
| Intermittent access intake escalation | 0.9 | 0.9 | 3.5 | 0.1 | 0.9 | -1.3 | 0.1 | -0.1 | -1.9 | -0.6 | 0.9 |
| Lifetime Intake | 0.9 | 1.0 | 2.2 | 1.2 | 0.4 | 0.4 | 0.7 | 1.5 | 0.9 | 1.3 | 0.9 |
| Progressive ratio test 1 inactive lever presses | 0.9 | 0.9 | 1.5 | -0.9 | -1.2 | -0.7 | -1.2 | -1.1 | 0.1 | -0.9 | -1.0 |
| Total zone transitions, NPP test | 0.9 | 1.2 | 3.3 | 0.6 | -0.8 | 1.0 | 0.9 | 0.6 | 1.8 | 1.8 | 0.6 |
| Locomotion velocity, NPP test | 0.9 | 1.4 | 2.4 | 1.2 | 0.2 | 1.5 | 0.9 | 1.2 | 1.6 | 1.4 | 0.7 |
| Bone: periosteal perimeter | 0.9 | 1.6 | 3.2 | 1.0 | 1.6 | 0.4 | 1.7 | 1.0 | -1.0 | 1.0 | 1.8 |
| Bone: trabecular tissue density | 0.9 | 1.3 | 3.4 | -1.1 | -0.4 | -1.1 | -0.8 | -1.2 | -1.8 | -1.2 | -0.9 |
| Seeking ratio, punishment vs. effort | 0.9 | 1.2 | 4.1 | 0.2 | 1.1 | -1.3 | -0.8 | 0.7 | -2.0 | -0.9 | -0.7 |
| Rb content in liver | 0.9 | 1.1 | 2.5 | -0.8 | -0.3 | -1.6 | -1.3 | -0.3 | -0.4 | -1.1 | -1.4 |
| Times rat made contact with spout | 0.8 | 0.9 | 2.2 | 1.3 | 1.5 | 0.4 | 0.6 | 0.8 | -0.8 | 0.0 | 1.1 |
| Condit. Reinf. active responses | 0.8 | 1.2 | 2.2 | 1.2 | 1.0 | 1.5 | 1.0 | 1.2 | 0.9 | 0.7 | 0.9 |
| Pavlov. Cond. lever contacts | 0.8 | 1.1 | 2.0 | 1.0 | 0.4 | 0.9 | 0.9 | 1.3 | 1.4 | 1.3 | 0.6 |
| Intermittent access day 1 total infusions | 0.8 | 0.9 | 2.2 | 1.2 | 0.7 | 0.6 | 0.8 | 1.5 | 0.6 | 1.1 | 0.7 |
| Intermittent access terminal intake (last 3 days) | 0.8 | 0.8 | 2.2 | 1.2 | 1.0 | -0.2 | 0.6 | 1.5 | -0.1 | 0.8 | 0.9 |
| Total sessions with >9 infusions | 0.8 | 0.9 | 2.7 | -0.7 | -1.6 | -1.3 | -0.9 | -0.4 | 1.1 | 0.1 | -0.6 |
| Locomotion distance, session 8 | 0.8 | 1.2 | 5.6 | 0.1 | -1.4 | 0.4 | -0.5 | 0.4 | 2.4 | 1.0 | -0.8 |
| Time in novel zone, hab. session 2 | 0.8 | 0.8 | 2.7 | -0.8 | -1.1 | -0.6 | -1.1 | -0.2 | 0.5 | -0.3 | -1.7 |
| Total zone transitions, hab. session 2 | 0.8 | 1.0 | 3.0 | 0.0 | -1.4 | 0.6 | 0.3 | 0.2 | 1.7 | 1.5 | -0.2 |
| Time in novel zone, NPP test | 0.8 | 0.8 | 1.4 | 1.2 | 0.1 | 1.0 | 0.6 | 0.8 | 1.2 | 1.1 | 0.5 |
| Pavlov. Cond. latency score | 0.8 | 1.0 | 1.9 | -0.9 | -0.1 | -1.3 | -1.1 | -0.9 | -1.0 | -1.4 | -1.0 |
| Bone: final moment | 0.8 | 1.3 | 3.5 | 1.3 | 1.5 | 0.7 | 0.9 | 1.9 | 0.2 | 0.9 | 0.9 |
| Bone: periosteal estimation | 0.8 | 1.6 | 3.1 | 1.1 | 1.7 | 0.4 | 1.6 | 1.2 | -0.8 | 1.0 | 1.8 |
| Bone: trabecular number | 0.8 | 1.3 | 2.1 | -1.4 | -0.9 | -1.4 | -1.0 | -1.2 | -0.5 | -1.1 | -1.2 |
| Bone: trabecular spacing | 0.8 | 1.1 | 1.8 | 1.4 | 1.2 | 1.1 | 0.9 | 1.0 | -0.1 | 0.7 | 1.2 |
| Active lever presses in extinction session 6 | 0.8 | 0.8 | 2.3 | -0.5 | -1.0 | -0.5 | -1.2 | -0.1 | 0.9 | -0.5 | -1.5 |
| Time in open arm after self-admin | 0.8 | 0.9 | 1.6 | 0.4 | -0.5 | 1.2 | 1.3 | -0.2 | 0.9 | 1.2 | 1.0 |
| Delta time to tail flick, vehicle, before/after SA | 0.8 | 0.8 | 2.0 | 0.1 | 0.7 | 0.4 | 1.4 | 0.5 | -0.9 | 1.0 | 1.2 |
| Ambulatory time after self-admin | 0.8 | 0.9 | 2.1 | -1.0 | -0.2 | -1.5 | -0.7 | -0.4 | -1.2 | -0.7 | -1.1 |
| Change in fecal boli incidents, locomotor task | 0.8 | 0.8 | 2.4 | 0.8 | -0.3 | 1.1 | 0.4 | 0.6 | 1.5 | 0.9 | 0.3 |
| Rest time, locomotor task time 1 | 0.8 | 0.9 | 1.7 | -1.0 | -0.6 | -0.8 | -1.0 | -1.2 | -0.4 | -1.3 | -0.9 |
| Food consumed during 24 hour testing period | 0.7 | 0.9 | 1.8 | 1.3 | 1.0 | 0.3 | 0.8 | 1.3 | -0.2 | 0.9 | 1.0 |
| Indifference point 0 sec | 0.7 | 1.2 | 3.6 | -0.7 | -1.2 | -0.5 | -1.5 | -0.2 | 1.1 | -0.5 | -1.9 |
| Delay discounting total patch changes 0 sec | 0.7 | 1.1 | 3.3 | -0.6 | -1.1 | -0.5 | -1.5 | -0.1 | 1.2 | -0.5 | -1.8 |
| Delay discounting total patch changes 6 sec | 0.7 | 1.1 | 3.9 | 1.1 | 0.3 | 0.6 | -0.0 | 1.6 | 2.0 | 0.9 | -0.0 |
| Locomotor testing distance | 0.7 | 1.1 | 3.8 | 0.7 | -0.5 | 2.0 | 0.4 | 0.2 | 1.9 | 0.9 | 0.1 |
| Reaction time num false alarms AUC | 0.7 | 1.0 | 2.3 | -1.5 | -1.1 | -0.9 | -0.6 | -1.2 | -0.9 | -0.7 | -1.0 |
| Cocaine response after cond. corrected | 0.7 | 0.8 | 2.3 | -0.4 | 0.4 | -1.1 | -0.3 | -1.0 | -1.5 | -1.3 | 0.4 |
| Cocaine response after cond. not corrected | 0.7 | 0.8 | 2.3 | -0.5 | 0.1 | -0.7 | -0.6 | -1.4 | -1.1 | -1.5 | 0.1 |
| Condit. Reinf. active minus inactive responses | 0.7 | 0.9 | 1.9 | 1.0 | 1.4 | 0.8 | 0.9 | 1.1 | 0.1 | 0.4 | 1.1 |
| Condit. Reinf. lever presses | 0.7 | 0.9 | 4.2 | 0.7 | -0.3 | 1.3 | 0.2 | 0.6 | 2.1 | 0.7 | -0.2 |
| Condit. Reinf. lever reinforcers received | 0.7 | 1.0 | 2.3 | 1.2 | 0.8 | 1.5 | 0.9 | 1.1 | 1.0 | 0.7 | 0.7 |
| Intermittent access total locomotion | 0.7 | 0.8 | 2.1 | 0.7 | 1.4 | -0.6 | 0.4 | 1.0 | -1.5 | 0.0 | 0.8 |
| Locomotion velocity, session 1 | 0.7 | 0.7 | 1.4 | 0.8 | 0.3 | 1.1 | 1.1 | 0.5 | 0.1 | 1.1 | 1.2 |
| Locomotion distance, session 1 | 0.7 | 0.9 | 2.5 | 0.7 | -0.6 | 1.2 | 0.5 | 0.8 | 1.6 | 1.3 | 0.3 |
| Total locomotion distance, hab. session 2 | 0.7 | 1.0 | 3.0 | 0.7 | -0.5 | 1.4 | 0.5 | 0.6 | 1.7 | 1.3 | 0.1 |
| Novelty place preference | 0.7 | 0.7 | 1.3 | 1.1 | 0.0 | 0.9 | 0.5 | 0.8 | 1.2 | 1.0 | 0.5 |
| Total locomotion distance, NPP test | 0.7 | 1.0 | 3.0 | 0.8 | -0.2 | 1.2 | 0.5 | 0.9 | 1.7 | 1.2 | 0.4 |
| Bone: final force | 0.7 | 1.2 | 3.4 | 1.2 | 1.3 | 0.6 | 0.9 | 1.8 | 0.5 | 1.0 | 0.8 |
| Delta time in open arm before/after self-admin | 0.7 | 0.7 | 2.0 | -0.8 | -1.4 | -0.2 | -0.4 | -1.1 | 0.9 | -0.2 | -0.5 |
| Sum of active levers in priming session hrs 5-6 | 0.7 | 0.7 | 1.8 | 1.0 | 1.3 | 0.3 | 0.6 | 0.9 | -1.0 | 0.2 | 0.7 |
| Time to tail flick, vehicle, before self-admin | 0.7 | 0.8 | 1.2 | -1.0 | -0.8 | -0.6 | -1.0 | -0.9 | 0.1 | -1.0 | -1.1 |
| Rest time, locomotor task time 2 | 0.7 | 0.8 | 1.8 | -0.8 | -1.3 | -0.1 | -1.0 | -1.2 | 0.5 | -0.9 | -0.8 |
| Glucose | 0.6 | 0.9 | 1.8 | 1.2 | 1.3 | 0.2 | 1.0 | 0.6 | -1.0 | 0.4 | 1.4 |
| Length without tail | 0.6 | 1.4 | 3.8 | 1.3 | 0.9 | 1.9 | 1.2 | 1.1 | 0.5 | 1.0 | 0.7 |
| Mean num. licks in bursts | 0.6 | 0.7 | 3.4 | -0.5 | -1.3 | 0.2 | -0.2 | -1.8 | 0.4 | -0.4 | 0.0 |
| Std. dev. time between licks in bursts | 0.6 | 0.7 | 1.7 | -0.3 | -0.0 | -1.2 | -1.3 | 0.4 | -0.0 | -0.8 | -1.3 |
| Delay discounting water rate 12 sec | 0.6 | 0.8 | 2.2 | 1.0 | 0.5 | 0.8 | 0.7 | 1.5 | 0.9 | 1.1 | 0.1 |
| Reaction time false alarm rate | 0.6 | 0.9 | 2.1 | -1.4 | -1.3 | -0.8 | -0.6 | -1.2 | -0.2 | -0.5 | -0.9 |
| Condit. Reinf. inactive responses | 0.6 | 0.8 | 3.1 | 0.5 | -0.7 | 1.4 | 0.2 | 0.2 | 1.8 | 0.7 | -0.2 |
| Post-drug Anxiety | 0.6 | 0.7 | 2.4 | 0.9 | 0.9 | 1.6 | 0.7 | 0.8 | -0.0 | 0.5 | 0.5 |
| Progressive ratio test 1 active lever presses | 0.6 | 0.6 | 1.0 | 1.0 | 0.3 | 0.5 | 0.7 | 0.9 | 0.4 | 1.0 | 0.9 |
| Progressive ratio test 2 inactive lever presses | 0.6 | 0.7 | 1.1 | 0.6 | 0.3 | 1.1 | 0.9 | 0.7 | 0.6 | 1.0 | 0.9 |
| Short access day 10 total infusions | 0.6 | 0.7 | 1.2 | -0.5 | -1.1 | -0.9 | -1.1 | -0.1 | 0.8 | -0.3 | -1.0 |
| Locomotion distance, session 2 | 0.6 | 0.8 | 2.8 | -0.5 | -1.7 | 0.3 | -0.7 | -0.7 | 1.2 | 0.2 | -0.9 |
| Degree of sensitization distance | 0.6 | 0.6 | 2.2 | 0.7 | 0.1 | 0.4 | -0.3 | 1.3 | 1.5 | 0.4 | -0.4 |
| Incentive salience index mean | 0.6 | 0.8 | 2.2 | 1.0 | 0.8 | 0.6 | 0.7 | 1.5 | 0.2 | 1.1 | 0.4 |
| Time in familiar zone, hab. session 2 | 0.6 | 0.7 | 1.7 | 0.8 | 0.8 | 1.0 | 1.0 | 0.2 | 0.2 | 0.4 | 1.3 |
| Locomotion velocity, hab. session 2 | 0.6 | 0.8 | 3.0 | 0.4 | -0.8 | 1.2 | 0.2 | 0.3 | 1.7 | 1.0 | -0.2 |
| Bone: maximum moment | 0.6 | 1.0 | 3.1 | 0.9 | 1.7 | 0.2 | 0.7 | 1.6 | -0.5 | 0.3 | 0.9 |
| Delay discount hyperbolic model param | 0.6 | 0.6 | 1.1 | 0.7 | 1.1 | 0.1 | 0.9 | 1.1 | -0.0 | 0.7 | 1.0 |
| K content in liver | 0.6 | 0.6 | 1.6 | -0.4 | 0.4 | -0.5 | -0.6 | -0.6 | -1.2 | -1.3 | -0.6 |
| Epididymis fat weight | 0.5 | 1.1 | 1.8 | 1.1 | 0.9 | 1.0 | 1.3 | 1.1 | 0.1 | 1.1 | 1.3 |
| Length with tail | 0.5 | 1.7 | 3.4 | 1.3 | 0.5 | 1.3 | 1.8 | 0.9 | 0.4 | 1.7 | 1.5 |
| Liver weight, left | 0.5 | 0.9 | 3.8 | -0.1 | 1.3 | -0.8 | 0.0 | 0.6 | -1.9 | -0.6 | -0.1 |
| Parametrial fat weight | 0.5 | 1.0 | 2.7 | 0.5 | 1.6 | -0.4 | 0.7 | 0.5 | -1.6 | -0.1 | 1.1 |
| Pavlov. Cond. magazine entry latency | 0.5 | 0.5 | 0.8 | -0.7 | -0.7 | -0.7 | -0.7 | -0.9 | -0.3 | -0.8 | -0.8 |
| Intermitt. access escalation Index | 0.5 | 0.4 | 1.2 | -0.5 | -1.1 | 0.6 | -0.1 | -0.8 | 0.9 | -0.0 | -0.4 |
| Intermittent access standard deviation | 0.5 | 0.5 | 2.1 | 0.1 | 0.6 | -1.4 | 0.1 | 0.4 | -0.9 | -0.1 | 0.8 |
| Progressive ratio test 1 breakpoint | 0.5 | 0.5 | 0.9 | 1.0 | 0.4 | 0.4 | 0.7 | 0.9 | 0.3 | 0.9 | 0.9 |
| Stereotopy head waving bouts, day 7 | 0.5 | 0.5 | 1.4 | -1.2 | -0.9 | -0.4 | -0.3 | -1.2 | -0.1 | -0.6 | -0.4 |
| Novel to familiar place preference ratio | 0.5 | 0.5 | 1.0 | 0.9 | -0.0 | 0.7 | 0.4 | 0.7 | 1.0 | 1.0 | 0.4 |
| Bone: cortical thickness | 0.5 | 0.6 | 1.4 | 0.9 | 0.6 | 0.9 | 1.1 | 0.3 | 0.3 | 0.6 | 1.2 |
| Bone: cortical tissue density | 0.5 | 0.7 | 1.5 | 0.6 | -0.1 | 1.0 | 0.5 | 1.0 | 1.2 | 1.1 | 0.1 |
| Bone: maximum force | 0.5 | 0.8 | 2.4 | 0.7 | 1.5 | 0.0 | 0.6 | 1.6 | -0.3 | 0.4 | 0.7 |
| Diff in mean of infusions in LGA sessions | 0.5 | 0.5 | 1.5 | 1.0 | 1.2 | 0.6 | 0.1 | 1.0 | -0.6 | -0.1 | 0.2 |
| Delta distance traveled before/after self-admin | 0.5 | 0.6 | 1.7 | 0.9 | 0.7 | 1.1 | 0.1 | 1.3 | 0.2 | 0.5 | -0.3 |
| Delta ambulatory time before/after self-admin | 0.5 | 0.6 | 1.5 | 0.8 | 0.4 | 1.0 | -0.1 | 1.2 | 0.7 | 0.5 | -0.5 |
| Time in closed arm after self-admin | 0.5 | 0.5 | 1.4 | -0.4 | -0.3 | -0.7 | -1.2 | 0.2 | 0.7 | -0.5 | -1.1 |
| Time >=10cm from walls, locomotor time 2 | 0.5 | 0.5 | 1.1 | 0.3 | -0.1 | 0.6 | 0.8 | 0.3 | 1.0 | 1.0 | 0.9 |
| Locomotion in novel chamber post-restriction | 0.5 | 0.6 | 1.2 | -0.5 | -1.1 | 1.0 | 0.1 | -1.0 | 1.0 | 0.3 | -0.1 |
| Latency to leave start box in cocaine runway | 0.5 | 0.6 | 1.3 | -0.2 | -0.2 | -0.7 | -1.1 | -0.5 | -0.5 | -1.1 | -1.0 |
| Cd content in liver | 0.5 | 0.6 | 2.7 | 0.5 | -0.2 | 0.5 | 0.1 | 0.8 | 1.7 | 0.9 | 0.1 |
| Soleus weight | 0.4 | 1.2 | 2.9 | 0.7 | -0.2 | 0.9 | 1.5 | 0.1 | 1.0 | 1.5 | 1.7 |
| Indifference point function ln k | 0.4 | 0.6 | 2.1 | -0.5 | -0.8 | -0.6 | -1.1 | -0.1 | 0.6 | -0.4 | -1.4 |
| Indifference point function log k | 0.4 | 0.6 | 2.1 | -0.5 | -0.8 | -0.6 | -1.1 | -0.1 | 0.6 | -0.4 | -1.4 |
| Reaction time mean | 0.4 | 0.6 | 2.0 | -0.9 | -0.6 | -0.3 | 0.1 | -1.4 | -1.0 | -0.5 | 0.1 |
| Reaction time mean AUC | 0.4 | 0.5 | 2.1 | -0.9 | -0.6 | -0.2 | 0.2 | -1.4 | -0.9 | -0.4 | 0.3 |
| Social response proportion | 0.4 | 0.5 | 1.8 | -0.7 | 0.2 | -0.2 | -0.3 | -0.6 | -1.3 | -0.9 | -0.4 |
| Social responses | 0.4 | 0.5 | 1.5 | 0.8 | 1.2 | 0.9 | 0.5 | 0.6 | -0.6 | -0.0 | 0.3 |
| Cocaine response before conditioning | 0.4 | 0.5 | 2.1 | 0.0 | -0.8 | 1.0 | -0.3 | -0.4 | 1.4 | 0.1 | -0.5 |
| Pavlov. Cond. magazine entry number | 0.4 | 0.5 | 1.1 | 0.6 | 0.3 | 1.0 | 0.5 | 0.9 | 0.6 | 0.7 | 0.5 |
| Cocaine induced anxiety | 0.4 | 0.5 | 1.0 | -0.7 | 0.1 | -0.2 | -0.7 | -0.3 | -0.9 | -0.9 | -1.0 |
| Incentive Sensitization - Breakpoint | 0.4 | 0.4 | 0.9 | 0.3 | 0.8 | -0.4 | 0.6 | 0.3 | -1.0 | 0.2 | 0.8 |
| One hour access (shock baseline) | 0.4 | 0.5 | 0.8 | 0.9 | 0.3 | 0.6 | 0.5 | 0.9 | 0.8 | 0.8 | 0.6 |
| Locomotion distance, session 7 | 0.4 | 0.6 | 1.6 | 0.8 | 0.1 | 0.5 | 0.0 | 1.1 | 1.3 | 0.8 | 0.0 |
| Total zone transitions, hab. session 1 | 0.4 | 0.6 | 2.5 | -0.6 | -1.6 | -0.4 | -0.2 | -0.4 | 0.8 | 0.7 | -0.3 |
| Pavlov. Cond. index score | 0.4 | 0.5 | 0.7 | -0.6 | -0.2 | -0.8 | -0.8 | -0.7 | -0.5 | -0.9 | -0.7 |
| Bone volume | 0.4 | 0.7 | 2.9 | -0.2 | 0.9 | -0.9 | 0.3 | -0.3 | -1.7 | -0.6 | 0.6 |
| Bone: cortical apparent density | 0.4 | 0.5 | 1.1 | 0.6 | 0.0 | 0.9 | 0.5 | 0.9 | 1.0 | 1.0 | 0.2 |
| Bone: maximum diameter | 0.4 | 0.7 | 1.8 | 0.6 | 1.4 | 0.0 | 0.9 | 0.8 | -0.9 | 0.3 | 1.0 |
| Distance traveled after self-admin | 0.4 | 0.4 | 1.5 | 0.2 | 0.8 | -0.3 | 0.5 | 0.7 | -1.2 | 0.3 | 0.2 |
| Time in closed arm before self-admin | 0.4 | 0.5 | 1.1 | -0.5 | -0.2 | -0.8 | -1.0 | -0.1 | 0.3 | -0.7 | -1.0 |
| Delay discount exponential model param | 0.4 | 0.5 | 1.2 | 0.5 | 1.1 | -0.2 | 0.7 | 0.9 | -0.3 | 0.4 | 0.8 |
| Total resting periods, locomotor time 1 | 0.4 | 0.5 | 1.6 | 0.3 | 1.0 | -0.7 | -0.2 | 0.1 | -1.3 | -0.8 | 0.2 |
| Locomotion in novel chamber | 0.4 | 0.5 | 2.0 | -0.1 | -0.6 | 0.7 | -0.3 | -0.8 | 1.4 | -0.3 | 0.1 |
| Latency to leave start box in cocaine runway, F | 0.4 | 0.4 | 0.9 | -0.3 | 0.1 | -0.9 | -0.8 | -0.2 | -0.9 | -0.8 | -0.7 |
| Na content in liver | 0.4 | 0.4 | 1.2 | -0.5 | 0.2 | -0.4 | -0.6 | -0.4 | -1.1 | -1.1 | -0.6 |
| Heart weight | 0.3 | 0.4 | 1.5 | 0.4 | 0.2 | 1.2 | 0.7 | 0.5 | 0.3 | 0.6 | 0.2 |
| Locomotor activity | 0.3 | 0.4 | 1.7 | 0.6 | -0.0 | 1.3 | 0.4 | 0.2 | 0.9 | 0.5 | 0.3 |
| Reaction time number correct | 0.3 | 0.5 | 1.2 | 0.7 | 1.1 | 0.5 | 0.3 | 0.7 | -1.0 | -0.2 | 0.2 |
| Reaction time trials correct on left | 0.3 | 0.5 | 1.2 | 0.7 | 1.1 | 0.5 | 0.3 | 0.7 | -1.0 | -0.2 | 0.2 |
| Reaction time trials on left | 0.3 | 0.4 | 1.1 | 0.6 | 1.0 | 0.5 | 0.3 | 0.6 | -1.0 | -0.3 | 0.2 |
| Reaction time premature initiation rate | 0.3 | 0.4 | 1.9 | 0.2 | -0.5 | 0.2 | 0.2 | 0.3 | 1.4 | 0.6 | 0.4 |
| Reaction time trials completed | 0.3 | 0.4 | 1.1 | 0.6 | 1.0 | 0.5 | 0.3 | 0.6 | -1.0 | -0.3 | 0.2 |
| Reaction time trials AUC | 0.3 | 0.4 | 1.0 | 0.7 | 1.0 | 0.6 | 0.4 | 0.8 | -0.8 | -0.1 | 0.2 |
| Pavlov. Cond. lever latency | 0.3 | 0.4 | 1.0 | -0.7 | -0.3 | -0.4 | -0.3 | -1.0 | -0.9 | -0.6 | 0.0 |
| Pavlov. Cond. response bias | 0.3 | 0.4 | 0.9 | 0.6 | 0.1 | 0.6 | 0.7 | 0.7 | 0.9 | 0.9 | 0.4 |
| Incentive Sensitization - Responses | 0.3 | 0.3 | 0.8 | 0.1 | 0.7 | -0.5 | 0.5 | 0.2 | -0.9 | 0.2 | 0.7 |
| Short access total infusions | 0.3 | 0.3 | 1.1 | 0.0 | -0.7 | -0.4 | -0.2 | 0.4 | 1.0 | 0.6 | -0.2 |
| Compulsive drug intake | 0.3 | 0.3 | 1.4 | 0.3 | 0.7 | -0.1 | 0.4 | -0.2 | -1.2 | -0.1 | 0.4 |
| Context. condit. distance diff. score | 0.3 | 0.4 | 1.6 | 0.1 | -0.4 | 0.0 | -0.3 | 0.5 | 1.3 | 0.5 | -0.6 |
| Stereotopy head waving bouts, day 3 | 0.3 | 0.4 | 0.8 | 0.3 | 0.4 | 0.8 | 0.9 | 0.7 | 0.2 | 0.8 | 0.8 |
| Pavlov. Cond. lever contacts | 0.3 | 0.4 | 1.0 | -0.4 | 0.4 | -0.8 | -0.4 | -0.2 | -1.0 | -0.8 | -0.4 |
| Bone: connectivity density | 0.3 | 0.4 | 0.7 | -0.5 | -0.2 | -0.9 | -0.9 | -0.4 | -0.3 | -0.8 | -0.8 |
| Breakpoint value in progressive ratio session | 0.3 | 0.3 | 1.0 | 0.9 | 0.5 | 0.2 | 0.2 | 1.0 | 0.5 | 0.7 | 0.1 |
| Time to tail flick, vehicle, after self-admin | 0.3 | 0.3 | 1.1 | -1.0 | -0.6 | -0.1 | 0.6 | -0.7 | -0.1 | 0.3 | 0.3 |
| Area under the delay curve | 0.3 | 0.4 | 1.0 | -0.4 | -1.0 | 0.3 | -0.6 | -0.8 | 0.4 | -0.3 | -0.7 |
| Delay disc. indifference point, 0s delay | 0.3 | 0.3 | 0.9 | -0.5 | 0.3 | -0.6 | -0.5 | -0.3 | -1.0 | -0.6 | -0.5 |
| Fecal boli incidents, locomotor time 1 | 0.3 | 0.3 | 0.8 | -0.6 | -0.0 | -0.2 | -0.3 | -0.8 | -0.9 | -0.8 | -0.2 |
| Bouts of movement, locomotor time 1 | 0.3 | 0.4 | 1.2 | 0.2 | 0.8 | -0.6 | -0.1 | -0.0 | -1.1 | -0.7 | 0.3 |
| Se content in liver | 0.3 | 0.3 | 0.8 | -0.6 | -0.8 | -0.6 | -0.5 | -0.9 | 0.2 | -0.3 | -0.3 |
| Tail length | 0.2 | 0.5 | 1.2 | 0.4 | 0.2 | 0.1 | 1.1 | 0.5 | -0.1 | 1.0 | 1.0 |
| Mean time between licks in bursts | 0.2 | 0.3 | 1.5 | -0.0 | 0.7 | -0.5 | 0.1 | 0.5 | -1.2 | 0.0 | 0.1 |
| Delay discounting total patch changes 12 sec | 0.2 | 0.2 | 0.8 | 0.6 | -0.0 | 0.5 | 0.0 | 0.6 | 0.9 | 0.6 | 0.0 |
| Delay discounting total patch changes 18 sec | 0.2 | 0.3 | 1.0 | 0.6 | 0.4 | -0.2 | -0.3 | 1.0 | 0.7 | 0.3 | 0.1 |
| Delay discounting time to switch 0 sec | 0.2 | 0.3 | 1.6 | -0.6 | -0.7 | -0.1 | 0.1 | -1.3 | -0.3 | -0.2 | 0.3 |
| Median of all reaction times | 0.2 | 0.3 | 0.6 | -0.2 | -0.2 | 0.5 | 0.6 | -0.8 | -0.5 | 0.2 | 0.7 |
| Reaction time premature initiations | 0.2 | 0.2 | 0.4 | 0.5 | 0.1 | 0.4 | 0.5 | 0.5 | 0.5 | 0.5 | 0.6 |
| Pavlov. Cond. latency score | 0.2 | 0.2 | 0.5 | -0.4 | -0.1 | -0.7 | -0.6 | -0.3 | -0.2 | -0.7 | -0.6 |
| Intermitt. access day 15 inactive lever presses | 0.2 | 0.2 | 1.0 | 0.2 | -0.1 | 1.0 | 0.4 | -0.1 | 0.3 | 0.3 | 0.3 |
| Intermittent access day 1 locomotion | 0.2 | 0.2 | 1.0 | 0.5 | 0.5 | 0.1 | 0.2 | 1.0 | 0.2 | 0.4 | -0.0 |
| Condit. Reinf. active responses | 0.2 | 0.3 | 1.1 | -0.4 | -0.7 | -0.3 | -0.6 | 0.1 | 0.1 | 0.1 | -1.1 |
| Total locomotion distance, hab. session 1 | 0.2 | 0.3 | 0.8 | -0.5 | -0.9 | -0.2 | -0.6 | -0.1 | 0.8 | -0.1 | -0.6 |
| Locomotion velocity, hab. session 1 | 0.2 | 0.3 | 1.2 | -0.2 | -0.8 | -0.0 | -0.5 | 0.1 | 1.1 | 0.2 | -0.4 |
| Pavlov. Cond. magazine entry number | 0.2 | 0.3 | 1.0 | 0.2 | 0.8 | 0.3 | 0.3 | 0.2 | -1.0 | -0.3 | 0.5 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.2 | 0.3 | 0.5 | -0.4 | -0.3 | -0.6 | -0.7 | -0.6 | -0.2 | -0.7 | -0.6 |
| Pavlov. Cond. response bias | 0.2 | 0.3 | 0.5 | -0.5 | -0.6 | -0.7 | -0.5 | -0.3 | 0.3 | -0.2 | -0.6 |
| Bone surface | 0.2 | 0.4 | 1.2 | 0.0 | 0.8 | -0.7 | 0.1 | -0.2 | -1.1 | -0.5 | 0.5 |
| Bone: endosteal perimeter | 0.2 | 0.4 | 0.9 | 0.4 | 0.9 | 0.3 | 0.9 | 0.6 | -0.7 | 0.5 | 0.7 |
| Bone: stiffness | 0.2 | 0.4 | 1.2 | 0.6 | 1.1 | -0.1 | 0.4 | 1.1 | -0.4 | 0.2 | 0.3 |
| Bone: trabecular thickness | 0.2 | 0.2 | 0.5 | -0.5 | -0.3 | -0.7 | -0.0 | -0.5 | -0.7 | -0.2 | -0.1 |
| Time to tail flick, test, after self-admin | 0.2 | 0.2 | 0.6 | -0.1 | 0.0 | 0.1 | 0.6 | 0.4 | -0.1 | 0.8 | 0.4 |
| Delay disc. indifference point, 16s delay | 0.2 | 0.2 | 0.4 | 0.3 | -0.4 | 0.5 | 0.2 | 0.2 | 0.6 | 0.6 | 0.3 |
| Distance moved, locomotor task time 2 | 0.2 | 0.3 | 0.6 | 0.3 | 0.2 | 0.5 | 0.4 | 0.6 | 0.8 | 0.8 | 0.2 |
| Vertical activity count, locomotor time 2 | 0.2 | 0.2 | 0.6 | 0.0 | -0.3 | 0.4 | 0.5 | -0.1 | 0.8 | 0.8 | 0.1 |
| Run reversals in cocaine runway, males | 0.2 | 0.2 | 0.6 | 0.8 | -0.0 | 0.3 | -0.0 | 0.4 | 0.6 | 0.1 | 0.3 |
| Latency to leave start box in cocaine runway, M | 0.2 | 0.2 | 0.7 | 0.2 | -0.1 | 0.2 | -0.8 | -0.0 | 0.5 | -0.6 | -0.6 |
| Mg content in liver | 0.2 | 0.2 | 0.6 | -0.2 | 0.1 | -0.3 | -0.6 | -0.2 | -0.2 | -0.8 | -0.6 |
| Intraocular pressure | 0.1 | 0.2 | 0.6 | -0.3 | -0.2 | 0.3 | 0.5 | -0.8 | -0.3 | -0.0 | 0.5 |
| Delay discounting total patch changes 24 sec | 0.1 | 0.1 | 0.3 | 0.2 | 0.1 | -0.5 | -0.3 | 0.5 | 0.1 | 0.1 | -0.4 |
| Delay discounting water rate 0 sec | 0.1 | 0.2 | 0.9 | 0.5 | 0.5 | -0.1 | -0.1 | 1.0 | 0.5 | 0.2 | -0.3 |
| Light reinforcement 2 | 0.1 | 0.2 | 0.5 | -0.2 | -0.0 | -0.3 | -0.5 | -0.3 | -0.4 | -0.6 | -0.7 |
| Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 0.3 | 0.4 | 0.3 | -0.1 | -0.1 | 0.6 | 0.2 | 0.0 | -0.3 |
| Pavlov. Cond. index score | 0.1 | 0.1 | 0.2 | -0.2 | -0.0 | -0.4 | -0.3 | -0.2 | -0.0 | -0.4 | -0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 0.3 | -0.2 | -0.1 | -0.6 | -0.3 | -0.3 | -0.1 | -0.5 | -0.3 |
| Number of responses in last shaping day | 0.1 | 0.1 | 0.1 | -0.1 | -0.4 | -0.4 | 0.0 | 0.1 | 0.3 | 0.2 | 0.3 |
| Locomotion velocity, session 3 | 0.1 | 0.1 | 0.4 | -0.2 | -0.1 | -0.1 | 0.5 | 0.2 | -0.2 | 0.6 | 0.5 |
| Locomotion distance, session 3 | 0.1 | 0.2 | 0.4 | 0.3 | 0.1 | 0.6 | 0.4 | 0.2 | 0.3 | 0.6 | 0.4 |
| Condit. Reinf. lever presses | 0.1 | 0.1 | 0.3 | -0.2 | 0.2 | -0.4 | -0.1 | -0.0 | -0.5 | -0.3 | -0.1 |
| Time in familiar zone, hab. session 1 | 0.1 | 0.1 | 0.2 | -0.5 | -0.3 | -0.4 | -0.3 | -0.2 | 0.2 | -0.2 | -0.1 |
| Time in novel zone, hab. session 1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.5 | 0.4 | 0.2 | -0.0 | -0.5 | -0.2 | 0.1 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.4 | -0.2 | -0.6 | -0.3 | -0.2 | -0.4 | 0.6 | 0.1 | -0.1 |
| Pavlov. Cond. intertrial magazine entries | 0.1 | 0.1 | 0.5 | -0.3 | -0.1 | -0.3 | -0.3 | 0.4 | -0.1 | 0.1 | -0.7 |
| Bone: apparent density | 0.1 | 0.2 | 0.9 | 0.0 | 0.7 | -0.5 | 0.1 | -0.0 | -1.0 | -0.3 | 0.3 |
| Bone: cortical porosity | 0.1 | 0.1 | 0.4 | -0.4 | -0.7 | -0.2 | -0.2 | -0.5 | 0.5 | -0.2 | -0.2 |
| Bone: cortical porosity | 0.1 | 0.1 | 0.4 | -0.0 | -0.5 | -0.1 | 0.1 | -0.1 | 0.6 | 0.2 | 0.2 |
| Bone: endosteal estimation | 0.1 | 0.1 | 0.5 | -0.0 | 0.6 | -0.4 | 0.1 | 0.2 | -0.7 | -0.2 | 0.2 |
| Bone: marrow area | 0.1 | 0.2 | 0.6 | -0.0 | 0.6 | -0.4 | 0.0 | 0.1 | -0.8 | -0.2 | 0.2 |
| Delta time in closed arm before/after self-admin | 0.1 | 0.1 | 0.4 | -0.6 | -0.3 | -0.5 | -0.2 | -0.0 | -0.3 | -0.1 | -0.4 |
| Delay disc. indifference point, 4s delay | 0.1 | 0.2 | 0.8 | 0.3 | 0.3 | -0.1 | -0.3 | 0.0 | -0.9 | -0.3 | -0.3 |
| Run reversals in cocaine runway, females | 0.1 | 0.1 | 0.3 | 0.2 | -0.1 | 0.4 | -0.5 | -0.2 | 0.3 | -0.5 | -0.3 |
| Co content in liver | 0.1 | 0.2 | 0.4 | 0.4 | -0.1 | -0.4 | 0.4 | 0.1 | 0.2 | 0.6 | 0.6 |
| Locomotion velocity, session 2 | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | 0.3 | -0.1 | -0.2 | -0.3 | -0.2 | -0.0 |
| Locomotion velocity, session 8 | 0.0 | 0.0 | 0.2 | 0.1 | -0.0 | 0.4 | -0.2 | 0.1 | 0.1 | -0.0 | -0.1 |
| Total heroin consumption | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | -0.1 | 0.0 | 0.2 | -0.1 | 0.1 | -0.0 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.