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Pavlov. Cond. response bias

Pavlovian Conditioned Approach, Sign/goal-tracking, average lever minus magazine contact number on days 4 and 5 of testing, normalized to 1/-1 by dividing by total contact number

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

2 loci · 10 genes with independent associations · 203 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	149199615	150594931	10	1	1.50e-09	9.06e-10	9.07e-02	Tenm4
2	chr1	151412751	157827195	193	9	6.03e-10	4.00e-09	1.00e+00	Arap1 Capn5 Dgat2 LOC120099889 Map6 Plekhb1 Slco2b1 Thap12 Uvrag

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Tail length	6.02	20	0	0	1	2.27e-33	Arap1 Art2b Atg16l2 Clpb Fchsd2 Folr2 Il18bp Lamtor1 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry2 P2ry6 Pgap2 Rhog Rnf121 Stim1 Trim68 Xndc1
Retroperitoneal fat weight	5.85	25	0	0	-1	5.93e-72	Acer3 C2cd3 Capn5 Dgat2 Dnajb13 Emsy Fam168a LOC100912071 LOC103691200 LOC120099889 LOC120099893 Lrrc32 Mrpl48 P2ry6 Pgm2l1 Plekhb1 Pold3 Rab6a Slco2b1 Tenm4 Thap12 Tsku Ucp2 Uvrag Wnt11
Mean time between licks in bursts	10.59	1	0	0	0	1.00e+00	Uvrag
Condit. Reinf. active minus inactive responses	12.91	4	0	0	1	5.47e-06	Atg16l2 LOC120097348 Plekhb1 Relt
Condit. Reinf. active responses	12.53	55	0	0	1	1.26e-217	Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Il18bp Lamtor1 Lipt2 LOC102553078 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099891 LOC120099895 LOC120099897 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rhog Rnf121 Rnf169 Serpinh1 Slco2b1 Stim1 Thap12 Trim68 Tsku Ucp2 Uvrag Wnt11 Xndc1
Condit. Reinf. lever presses	20.76	67	56	560	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 C2cd3 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Il18bp Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099893 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Rab6a Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Trim68 Tsku Ucp2 Uvrag Wnt11 Xndc1
Condit. Reinf. lever reinforcers received	12.92	57	2	20	1	3.06e-289	Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Il18bp Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099891 LOC120099895 LOC120099897 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Thap12 Trim68 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. lever latency	21.6	67	61	610	-1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 C2cd3 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Il18bp Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099893 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Rab6a Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Trim68 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. change in total contacts	16.16	67	13	130	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 C2cd3 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Il18bp Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099893 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Rab6a Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Trim68 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. index score	17.08	67	2	20	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 C2cd3 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Il18bp Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099893 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Rab6a Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Trim68 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. latency score	15.46	67	0	0	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 C2cd3 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Il18bp Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099893 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Rab6a Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Trim68 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. lever contacts	22.54	67	67	670	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 C2cd3 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Il18bp Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099893 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Rab6a Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Trim68 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. magazine entry number	14.21	8	0	0	-1	1.06e-26	Capn5 Clpb LOC120097348 LOC120099897 Numa1 Pde2a Stim1 Tenm4
Pavlov. Cond. lever-magazine prob. diff.	15.99	67	0	0	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 C2cd3 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Il18bp Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099893 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Nup98 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pde2a Pgap2 Pgm2l1 Plekhb1 Pold3 Ppme1 Rab6a Relt Rhog Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Stim1 Tenm4 Thap12 Trim68 Tsku Ucp2 Uvrag Wnt11 Xndc1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	13	0.4	1.38
Adipose	alternative TSS	15	0.4	1.47
Adipose	gene expression	15	0.2	1.38
Adipose	isoform ratio	16	0.3	1.43
Adipose	intron excision ratio	5	0.2	1.21
Adipose	mRNA stability	11	0.2	1.42
BLA	alternative polyA	3	0.1	1.39
BLA	alternative TSS	7	0.4	1.38
BLA	gene expression	15	0.2	1.37
BLA	isoform ratio	5	0.2	1.41
BLA	intron excision ratio	4	0.1	1.32
BLA	mRNA stability	5	0.2	1.4
Brain	alternative polyA	2	0.1	1.36
Brain	alternative TSS	12	0.3	1.34
Brain	gene expression	16	0.2	1.36
Brain	isoform ratio	8	0.1	1.36
Brain	intron excision ratio	9	0.2	1.29
Brain	mRNA stability	10	0.2	1.36
Eye	alternative polyA	0	0	1.39
Eye	alternative TSS	2	0.5	1.34
Eye	gene expression	4	0.3	1.46
Eye	isoform ratio	0	0	1.24
Eye	intron excision ratio	1	0.1	1.32
Eye	mRNA stability	0	0	1.49
IL	alternative polyA	0	0	1.27
IL	alternative TSS	0	0	1.22
IL	gene expression	5	0.1	1.37
IL	isoform ratio	1	0.1	1.4
IL	intron excision ratio	1	0.1	1.28
IL	mRNA stability	1	0.1	1.34
LHb	alternative polyA	0	0	1.41
LHb	alternative TSS	0	0	1.49
LHb	gene expression	4	0.1	1.35
LHb	isoform ratio	2	0.2	1.35
LHb	intron excision ratio	0	0	1.24
LHb	mRNA stability	0	0	1.29
Liver	alternative polyA	4	0.2	1.29
Liver	alternative TSS	5	0.2	1.39
Liver	gene expression	18	0.2	1.42
Liver	isoform ratio	8	0.2	1.39
Liver	intron excision ratio	12	0.2	1.38
Liver	mRNA stability	5	0.2	1.41
NAcc	alternative polyA	4	0.1	1.42
NAcc	alternative TSS	8	0.3	1.34
NAcc	gene expression	14	0.2	1.38
NAcc	isoform ratio	5	0.1	1.38
NAcc	intron excision ratio	4	0.1	1.27
NAcc	mRNA stability	8	0.2	1.36
OFC	alternative polyA	4	0.4	1.41
OFC	alternative TSS	0	0	1.29
OFC	gene expression	2	0	1.36
OFC	isoform ratio	3	0.2	1.44
OFC	intron excision ratio	0	0	1.26
OFC	mRNA stability	2	0.1	1.39
PL	alternative polyA	13	0.4	1.52
PL	alternative TSS	3	0.1	1.36
PL	gene expression	16	0.2	1.37
PL	isoform ratio	4	0.1	1.35
PL	intron excision ratio	7	0.1	1.29
PL	mRNA stability	6	0.2	1.39
pVTA	alternative polyA	3	0.2	1.47
pVTA	alternative TSS	3	0.2	1.34
pVTA	gene expression	10	0.2	1.38
pVTA	isoform ratio	4	0.2	1.33
pVTA	intron excision ratio	4	0.1	1.26
pVTA	mRNA stability	3	0.2	1.38
RMTg	alternative polyA	0	0	1.16
RMTg	alternative TSS	1	0.2	1.25
RMTg	gene expression	1	0.1	1.39
RMTg	isoform ratio	0	0	1.15
RMTg	intron excision ratio	0	0	1.3
RMTg	mRNA stability	1	0.2	1.38