Hub : Traits

Pavlov. Cond. response bias

Pavlovian Conditioned Approach, Sign/goal-tracking, average lever minus magazine contact number on days 4 and 5 of testing, normalized to 1/-1 by dividing by total contact number

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

238 significantly associated models · 62 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 149862595 157352620 59 7 8.3e-10 4.0e-09 1.000 100 Nars2 Emsy Dgat2 Mrpl48 Plekhb1 Arap1 Stim1
2 5 74868378 76264539 1 1 1.2e-07 3.1e-02 0.023 -11 RGD1566134
3 7 16845355 16970279 1 1 4.1e-17 NaN NA NA NA

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 171.8 1 1 11 0.00 1.0e+00 NA
Body weight 11.2 1 1 11 0.00 1.0e+00 NA
Epididymis fat weight 136.2 1 1 11 0.00 1.0e+00 NA
Heart weight 11.4 1 0 0 0.00 1.0e+00 NA
Left kidney weight 62.7 1 1 11 0.00 1.0e+00 NA
Right kidney weight 67.3 1 1 11 0.00 1.0e+00 NA
Tail length 8.5 16 1 11 0.64 8.9e-05 Mrpl48 Plekhb1 P2ry6 P2ry2 Fchsd2 Arap1 Art2b Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 NA
Length with tail 4.0 1 0 0 0.00 1.0e+00 NA
Length without tail 120.2 1 1 11 0.00 1.0e+00 NA
Liver weight, left 23.6 1 1 11 0.00 1.0e+00 NA
Liver weight, right 9.6 1 0 0 0.00 1.0e+00 NA
Parametrial fat weight 26.4 1 1 11 0.00 1.0e+00 NA
Retroperitoneal fat weight 5.4 27 0 0 -0.99 5.9e-50 Capn5 Emsy Uvrag Dgat2 Lipt2 Pgm2l1 Ppme1 Ucp2 Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 Rsf1 Relt Mogat2 Tsku Gdpd5 Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA Coa4
Intraocular pressure 29.4 1 1 11 0.00 1.0e+00 NA
Extensor digitorum longus weight 39.2 1 1 11 0.00 1.0e+00 NA
Soleus weight 21.9 1 1 11 0.00 1.0e+00 NA
Tibialis anterior weight 96.0 1 1 11 0.00 1.0e+00 NA
Tibia length 7.4 1 0 0 0.00 1.0e+00 NA
Number of licking bursts 242.4 1 1 11 0.00 1.0e+00 NA
Food consumed during 24 hour testing period 17.5 1 0 0 0.00 1.0e+00 NA
Times rat made contact with spout 121.6 1 1 11 0.00 1.0e+00 NA
Mean time between licks in bursts 90.5 1 1 11 0.00 1.0e+00 NA
Mean num. licks in bursts 258.2 1 1 11 0.00 1.0e+00 NA
Std. dev. time between licks in bursts 291.0 1 1 11 0.00 1.0e+00 NA
Indifference point 0 sec 21.3 1 1 11 0.00 1.0e+00 NA
Indifference point AUC 66.7 1 1 11 0.00 1.0e+00 NA
Delay discounting total patch changes 0 sec 20.1 1 1 11 0.00 1.0e+00 NA
Delay discounting total patch changes 12 sec 156.9 1 1 11 0.00 1.0e+00 NA
Delay discounting total patch changes 18 sec 277.7 1 1 11 0.00 1.0e+00 NA
Delay discounting total patch changes 24 sec 43.7 1 1 11 0.00 1.0e+00 NA
Delay discounting total patch changes 6 sec 145.0 1 1 11 0.00 1.0e+00 NA
Delay discounting water rate 0 sec 11.8 1 0 0 0.00 1.0e+00 NA
Delay discounting water rate 12 sec 44.2 1 1 11 0.00 1.0e+00 NA
Delay discounting water rate 18 sec 10.5 1 0 0 0.00 1.0e+00 NA
Delay discounting water rate 24 sec 100.9 1 1 11 0.00 1.0e+00 NA
Delay discounting water rate 6 sec 70.2 1 1 11 0.00 1.0e+00 NA
Locomotor testing distance 14.0 1 0 0 0.00 1.0e+00 NA
Locomotor testing rearing 23.9 1 1 11 0.00 1.0e+00 NA
Light reinforcement 1 84.1 1 1 11 0.00 1.0e+00 NA
Reaction time num false alarms 90.1 1 1 11 0.00 1.0e+00 NA
Reaction time num false alarms AUC 128.2 1 1 11 0.00 1.0e+00 NA
Reaction time trials on left 10.3 1 0 0 0.00 1.0e+00 NA
Reaction time mean 62.5 1 1 11 0.00 1.0e+00 NA
Reaction time mean AUC 89.1 1 1 11 0.00 1.0e+00 NA
Median of all reaction times 80.2 1 1 11 0.00 1.0e+00 NA
Reaction time false alarm rate 104.2 1 1 11 0.00 1.0e+00 NA
Reaction time premature initiation rate 47.3 1 1 11 0.00 1.0e+00 NA
Reaction time premature initiations 49.8 1 1 11 0.00 1.0e+00 NA
Std. dev. reaction times 27.0 1 1 11 0.00 1.0e+00 NA
Reaction time trials completed 10.3 1 0 0 0.00 1.0e+00 NA
Reaction time trials AUC 15.6 1 0 0 0.00 1.0e+00 NA
Social responses 108.6 1 1 11 0.00 1.0e+00 NA
Cocaine response after cond. corrected 135.7 1 1 11 0.00 1.0e+00 NA
Cocaine response after cond. not corrected 176.6 1 1 11 0.00 1.0e+00 NA
Cocaine response before conditioning 28.6 1 1 11 0.00 1.0e+00 NA
Saline control response 34.0 2 1 11 0.00 1.0e+00 NA RGD1566134
Condit. Reinf. active minus inactive responses 15.0 4 1 11 0.66 1.1e-02 Mrpl48 P2ry2 Arap1 NA
Condit. Reinf. active-inactive response ratio 68.7 1 1 11 0.00 1.0e+00 NA
Condit. Reinf. active responses 12.5 43 0 0 0.97 1.7e-88 Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 Map6 Mogat2 Tsku AABR07004881.1 Arhgef17 Thap12 NA NA NA
Condit. Reinf. inactive responses 12.4 4 0 0 1.00 1.1e-09 Mrpl48 P2ry2 Arap1 NA
Condit. Reinf. lever presses 20.0 61 40 444 1.00 7.5e-297 Numa1 Nars2 Gab2 Ndufc2 Thrsp Kctd14 Aamdc Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Pde2a Art2b Clpb Inppl1 Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 Rsf1 Relt Map6 Mogat2 Tsku Pak1 Gdpd5 Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA RGD1566134 NA Coa4 NA NA
Condit. Reinf. lever reinforcers received 13.2 44 3 33 1.00 1.2e-171 Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 Relt Map6 Mogat2 Tsku AABR07004881.1 Arhgef17 Thap12 NA NA NA
Pavlov. Cond. lever latency 21.4 62 59 656 -1.00 0.0e+00 Numa1 Nars2 Gab2 Ndufc2 Thrsp Kctd14 Aamdc Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Pde2a Art2b Clpb Inppl1 Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 Rsf1 Relt Map6 Mogat2 Tsku Pak1 Gdpd5 Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA RGD1566134 NA Coa4 NA NA
Pavlov. Cond. magazine entry latency 66.5 3 1 11 0.00 1.0e+00 NA RGD1566134 NA
Pavlov. Cond. change in total contacts 17.1 62 13 144 0.99 4.4e-197 Numa1 Nars2 Gab2 Ndufc2 Thrsp Kctd14 Aamdc Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Pde2a Art2b Clpb Inppl1 Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 Rsf1 Relt Map6 Mogat2 Tsku Pak1 Gdpd5 Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA RGD1566134 NA Coa4 NA NA
Pavlov. Cond. index score 17.1 62 7 78 1.00 3.0e-279 Numa1 Nars2 Gab2 Ndufc2 Thrsp Kctd14 Aamdc Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Pde2a Art2b Clpb Inppl1 Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 Rsf1 Relt Map6 Mogat2 Tsku Pak1 Gdpd5 Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA RGD1566134 NA Coa4 NA NA
Pavlov. Cond. latency score 15.6 62 2 22 1.00 6.6e-253 Numa1 Nars2 Gab2 Ndufc2 Thrsp Kctd14 Aamdc Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Pde2a Art2b Clpb Inppl1 Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 Rsf1 Relt Map6 Mogat2 Tsku Pak1 Gdpd5 Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA RGD1566134 NA Coa4 NA NA
Pavlov. Cond. lever contacts 22.0 62 57 633 1.00 0.0e+00 Numa1 Nars2 Gab2 Ndufc2 Thrsp Kctd14 Aamdc Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Pde2a Art2b Clpb Inppl1 Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 Rsf1 Relt Map6 Mogat2 Tsku Pak1 Gdpd5 Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA RGD1566134 NA Coa4 NA NA
Pavlov. Cond. magazine entry number 20.1 19 1 11 -0.94 4.3e-17 Numa1 Nars2 Gab2 Ndufc2 Thrsp Kctd14 Aamdc Capn5 Pde2a Clpb Anapc15 Nup98 Pgap2 Stim1 Rsf1 Pak1 NA RGD1566134 NA
Pavlov. Cond. intertrial magazine entries 106.2 1 1 11 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 16.0 62 1 11 1.00 2.1e-286 Numa1 Nars2 Gab2 Ndufc2 Thrsp Kctd14 Aamdc Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Pde2a Art2b Clpb Inppl1 Folr2 Anapc15 Rnf121 Trpc2 Nup98 Pgap2 Rhog Stim1 Rsf1 Relt Map6 Mogat2 Tsku Pak1 Gdpd5 Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA RGD1566134 NA Coa4 NA NA
Conditioned reinforcement - actives 18.5 1 0 0 0.00 1.0e+00 NA
Intermittent access intake day 1-15 change 104.0 1 1 11 0.00 1.0e+00 NA
Intermittent access intake escalation 141.1 1 1 11 0.00 1.0e+00 NA
Intermittent access intake escalation 2 42.5 1 1 11 0.00 1.0e+00 NA
Intermitt. access day 1 inactive lever presses 30.6 1 1 11 0.00 1.0e+00 NA
Intermittent access day 1 total infusions 43.5 2 2 22 0.00 1.0e+00 NA RGD1566134
Intermittent access day 1 locomotion 27.1 1 1 11 0.00 1.0e+00 NA
Post-drug Anxiety 20.6 1 0 0 0.00 1.0e+00 NA
Baseline Anxiety 17.3 1 0 0 0.00 1.0e+00 RGD1566134
Lifetime Intake 24.7 1 1 11 0.00 1.0e+00 RGD1566134
Progressive ratio test 2 active lever presses 14.4 1 0 0 0.00 1.0e+00 RGD1566134
Progressive ratio test 2 breakpoint 38.3 2 1 11 0.00 1.0e+00 NA RGD1566134
Total sessions with >9 infusions 15.1 1 0 0 0.00 1.0e+00 RGD1566134
Short access day 1 total infusions 21.8 1 0 0 0.00 1.0e+00 RGD1566134
Short access day 10 total infusions 21.3 2 1 11 0.00 1.0e+00 NA RGD1566134
Short access total infusions 56.6 1 1 11 0.00 1.0e+00 RGD1566134
Short access day 1 locomotion 17.2 1 0 0 0.00 1.0e+00 NA
Compulsive drug intake 45.4 1 1 11 0.00 1.0e+00 NA
Context. condit. distance diff. score 240.2 1 1 11 0.00 1.0e+00 NA
Locomotion velocity, session 1 190.8 1 1 11 0.00 1.0e+00 NA
Locomotion distance, session 1 609.6 1 1 11 0.00 1.0e+00 NA
Locomotion velocity, session 2 139.6 1 1 11 0.00 1.0e+00 NA
Locomotion distance, session 2 1269.9 1 1 11 0.00 1.0e+00 NA
Locomotion velocity, session 3 178.9 1 1 11 0.00 1.0e+00 NA
Locomotion distance, session 3 117.5 1 1 11 0.00 1.0e+00 NA
Stereotopy head waving duration, day 3 24.4 2 1 11 0.00 1.0e+00 NA RGD1566134
Locomotion velocity, session 7 98.9 1 1 11 0.00 1.0e+00 NA
Locomotion distance, session 7 31.8 1 1 11 0.00 1.0e+00 NA
Stereotopy head waving bouts, day 7 47.4 2 2 22 0.00 1.0e+00 NA RGD1566134
Stereotopy head waving duration, day 7 60.0 2 1 11 0.00 1.0e+00 NA RGD1566134
Locomotion distance, session 8 171.7 1 1 11 0.00 1.0e+00 NA
Degree of sensitization distance 198.5 1 1 11 0.00 1.0e+00 NA
Degree of sensitization stereotypy 26.8 2 1 11 0.00 1.0e+00 NA RGD1566134
Condit. Reinf. active-inactive response ratio 107.3 1 1 11 0.00 1.0e+00 NA
Condit. Reinf. active responses 16.6 2 0 0 0.00 1.0e+00 NA RGD1566134
Condit. Reinf. inactive responses 17.2 1 0 0 0.00 1.0e+00 NA
Incentive salience index mean 15.6 1 0 0 0.00 1.0e+00 NA
Condit. Reinf. lever presses 35.1 1 1 11 0.00 1.0e+00 NA
Time in familiar zone, hab. session 1 16.4 1 0 0 0.00 1.0e+00 NA
Time in novel zone, hab. session 1 17.4 1 0 0 0.00 1.0e+00 NA
Total zone transitions, hab. session 1 673.8 1 1 11 0.00 1.0e+00 NA
Total locomotion distance, hab. session 1 279.4 1 1 11 0.00 1.0e+00 NA
Locomotion velocity, hab. session 1 349.5 1 1 11 0.00 1.0e+00 NA
Time in familiar zone, hab. session 2 48.9 1 1 11 0.00 1.0e+00 NA
Time in novel zone, hab. session 2 58.4 1 1 11 0.00 1.0e+00 NA
Total zone transitions, hab. session 2 421.2 1 1 11 0.00 1.0e+00 NA
Total locomotion distance, hab. session 2 214.3 1 1 11 0.00 1.0e+00 NA
Locomotion velocity, hab. session 2 225.0 1 1 11 0.00 1.0e+00 NA
Total zone transitions, NPP test 376.1 1 1 11 0.00 1.0e+00 NA
Total locomotion distance, NPP test 269.3 1 1 11 0.00 1.0e+00 NA
Locomotion velocity, NPP test 317.8 1 1 11 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 95.9 1 1 11 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 40.1 1 1 11 0.00 1.0e+00 NA
Pavlov. Cond. index score 51.9 1 1 11 0.00 1.0e+00 NA
Pavlov. Cond. latency score 16.6 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 16.1 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 61.6 1 1 11 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 88.1 1 1 11 0.00 1.0e+00 NA
Pavlov. Cond. response bias 52.4 1 1 11 0.00 1.0e+00 NA
Bone: apparent density 21.4 2 1 11 0.00 1.0e+00 NA RGD1566134
Bone surface 27.9 2 1 11 0.00 1.0e+00 NA RGD1566134
Bone volume 29.6 2 1 11 0.00 1.0e+00 NA RGD1566134
Bone: cortical porosity 188.5 1 1 11 0.00 1.0e+00 NA
Bone: cortical porosity 155.8 1 1 11 0.00 1.0e+00 NA
Bone: cortical thickness 8.8 1 0 0 0.00 1.0e+00 NA
Bone: cortical thickness 17.9 1 0 0 0.00 1.0e+00 NA
Bone: elastic displacement 28.2 1 1 11 0.00 1.0e+00 NA
Bone: endosteal estimation 18.4 1 1 11 0.00 1.0e+00 NA
Bone: endosteal perimeter 7.0 1 0 0 0.00 1.0e+00 RGD1566134
Bone: final force 57.4 1 1 11 0.00 1.0e+00 NA
Bone: final moment 45.6 1 1 11 0.00 1.0e+00 NA
Bone: marrow area 15.3 1 1 11 0.00 1.0e+00 NA
Bone: maximum force 60.3 1 1 11 0.00 1.0e+00 NA
Bone: maximum moment 41.2 1 1 11 0.00 1.0e+00 NA
Bone: minimum diameter 86.7 1 1 11 0.00 1.0e+00 NA
Bone: periosteal estimation 10.0 1 0 0 0.00 1.0e+00 NA
Bone: periosteal perimeter 8.8 1 0 0 0.00 1.0e+00 NA
Bone: post-yield work 124.3 1 1 11 0.00 1.0e+00 NA
Bone: stiffness 136.8 1 1 11 0.00 1.0e+00 NA
Bone: tissue strength 136.0 1 1 11 0.00 1.0e+00 NA
Bone: trabecular number 64.1 1 1 11 0.00 1.0e+00 NA
Bone: trabecular thickness 13.8 1 0 0 0.00 1.0e+00 NA
Bone: trabecular tissue density 66.6 1 1 11 0.00 1.0e+00 NA
Delta time in open arm before/after self-admin 40.2 1 1 11 0.00 1.0e+00 NA
Time in closed arm before self-admin 78.0 1 1 11 0.00 1.0e+00 NA
Time in closed arm after self-admin 40.2 1 1 11 0.00 1.0e+00 NA
Time in open arm after self-admin 31.3 1 1 11 0.00 1.0e+00 NA
Delta time to tail flick, test, before/after SA 20.0 1 0 0 0.00 1.0e+00 NA
Delay disc. indifference point, 4s delay 23.4 1 0 0 0.00 1.0e+00 RGD1566134
Time >=10cm from walls, locomotor time 1 19.5 1 0 0 0.00 1.0e+00 NA
Time >=10cm from walls, locomotor time 2 21.0 2 1 11 0.00 1.0e+00 NA RGD1566134
Distance moved, locomotor task time 2 13.1 1 0 0 0.00 1.0e+00 NA
Weight adjusted by age 25.0 1 1 11 0.00 1.0e+00 NA
Seeking ratio, delayed vs. immediate footshock 23.8 1 1 11 0.00 1.0e+00 RGD1566134
Run reversals in cocaine runway, males 39.3 1 1 11 0.00 1.0e+00 NA
Latency to leave start box in cocaine runway 18.8 1 0 0 0.00 1.0e+00 NA
Cd content in liver 239.3 1 1 11 0.00 1.0e+00 NA
Co content in liver 143.3 1 1 11 0.00 1.0e+00 NA
K content in liver 87.3 1 1 11 0.00 1.0e+00 NA
Mn content in liver 207.1 1 1 11 0.00 1.0e+00 NA
Na content in liver 15.7 1 0 0 0.00 1.0e+00 RGD1566134
Rb content in liver 31.4 1 1 11 0.00 1.0e+00 NA
Se content in liver 47.0 1 1 11 0.00 1.0e+00 NA
Zn content in liver 30.5 2 1 11 0.00 1.0e+00 NA RGD1566134

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 12 0.566 1.5
Adipose alternative TSS 6 0.372 1.4
Adipose gene expression 15 0.181 1.4
Adipose isoform ratio 4 0.142 1.4
Adipose intron excision ratio 5 0.171 1.2
Adipose mRNA stability 9 0.261 1.5
BLA alternative polyA 0 0.000 1.5
BLA alternative TSS 4 0.475 1.5
BLA gene expression 13 0.214 1.4
BLA isoform ratio 0 0.000 1.3
BLA intron excision ratio 3 0.100 1.3
BLA mRNA stability 3 0.148 1.4
Brain alternative polyA 3 0.150 1.5
Brain alternative TSS 4 0.233 1.3
Brain gene expression 15 0.166 1.4
Brain isoform ratio 6 0.190 1.4
Brain intron excision ratio 5 0.093 1.3
Brain mRNA stability 9 0.206 1.4
Eye alternative polyA 0 0.000 1.1
Eye alternative TSS 1 0.417 1.2
Eye gene expression 1 0.089 1.4
Eye isoform ratio 0 0.000 1.5
Eye intron excision ratio 2 0.326 1.4
Eye mRNA stability 1 0.429 1.6
IL alternative polyA 0 0.000 1.4
IL alternative TSS 0 0.000 1.2
IL gene expression 9 0.247 1.4
IL isoform ratio 0 0.000 1.3
IL intron excision ratio 1 0.104 1.4
IL mRNA stability 1 0.090 1.3
LHb alternative polyA 0 0.000 1.4
LHb alternative TSS 0 0.000 1.2
LHb gene expression 3 0.094 1.4
LHb isoform ratio 0 0.000 1.4
LHb intron excision ratio 0 0.000 1.3
LHb mRNA stability 0 0.000 1.4
Liver alternative polyA 7 0.466 1.6
Liver alternative TSS 5 0.329 1.4
Liver gene expression 16 0.222 1.4
Liver isoform ratio 3 0.125 1.4
Liver intron excision ratio 12 0.274 1.4
Liver mRNA stability 7 0.285 1.4
NAcc alternative polyA 0 0.000 1.5
NAcc alternative TSS 0 0.000 1.3
NAcc gene expression 10 0.159 1.4
NAcc isoform ratio 1 0.053 1.4
NAcc intron excision ratio 5 0.163 1.3
NAcc mRNA stability 6 0.265 1.5
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.1
OFC gene expression 3 0.081 1.4
OFC isoform ratio 1 0.123 1.4
OFC intron excision ratio 0 0.000 1.2
OFC mRNA stability 1 0.093 1.5
PL alternative polyA 0 0.000 1.4
PL alternative TSS 2 0.170 1.4
PL gene expression 15 0.203 1.4
PL isoform ratio 1 0.045 1.4
PL intron excision ratio 0 0.000 1.2
PL mRNA stability 8 0.274 1.5

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.