Hub : Genes

Dpf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000020892 0.06 0.03 4.9e-06 0.03 0.04 0.04 0.04 5.7e-04 1.4e-05 1.7e-05 2.9e-05
2 Adipose mRNA stability ENSRNOG00000020892 0.06 0.04 4.9e-06 0.02 0.03 0.03 0.03 4.5e-03 2.2e-04 2.4e-04 5.6e-04
3 Liver gene expression ENSRNOG00000020892 0.1 0.05 3.6e-10 0.07 0.06 0.07 0.07 1.7e-08 1.4e-07 7.3e-08 6.6e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail3.411.023.3-4.8-0.9-3.0
BMI without tail1.43.06.6-2.6-0.6-1.4
Body weight3.916.622.1-4.7-3.2-4.2
Epididymis fat weight2.66.17.71.82.82.7
Glucose2.03.05.00.82.21.8
Heart weight3.55.06.12.02.22.5
Left kidney weight0.61.82.21.11.51.4
Right kidney weight0.10.30.30.50.60.5
Tail length0.72.35.3-0.2-2.3-1.2
Length with tail2.17.810.9-2.0-3.3-2.9
Length without tail2.55.57.0-2.1-2.3-2.6
Liver weight, left0.00.00.10.10.30.2
Liver weight, right0.00.00.10.20.00.3
Parametrial fat weight2.34.48.00.92.82.1
Retroperitoneal fat weight5.417.721.13.54.64.5
Intraocular pressure0.81.21.81.30.71.1
Extensor digitorum longus weight7.730.734.3-5.9-4.9-5.8
Soleus weight4.011.713.93.23.33.7
Tibialis anterior weight10.937.442.5-5.7-6.1-6.5
Tibia length1.02.73.3-1.7-1.4-1.8
Number of licking bursts0.30.30.5-0.6-0.4-0.7
Food consumed during 24 hour testing period0.10.10.10.2-0.4-0.2
Times rat made contact with spout0.40.40.5-0.5-0.7-0.7
Mean time between licks in bursts0.70.91.8-0.3-1.3-1.0
Mean num. licks in bursts0.20.20.30.60.30.6
Std. dev. time between licks in bursts0.20.20.40.7-0.50.1
Water consumed over 24 hours0.70.91.4-0.5-1.2-1.0
Indifference point 0 sec0.00.00.10.10.30.1
Indifference point AUC3.33.94.6-1.9-1.9-2.1
Indifference point function ln k8.211.614.13.43.03.7
Indifference point function log k8.211.614.13.43.03.7
Delay discounting total patch changes 0 sec0.00.00.10.3-0.00.0
Delay discounting total patch changes 12 sec4.66.27.6-2.5-2.1-2.7
Delay discounting total patch changes 18 sec0.50.71.2-1.1-0.4-0.9
Delay discounting total patch changes 24 sec2.53.13.9-1.4-2.0-1.9
Delay discounting total patch changes 6 sec0.91.41.8-1.2-1.0-1.4
Delay discounting time to switch 0 sec2.33.56.9-2.6-0.5-1.8
Delay discounting water rate 0 sec4.47.011.63.41.52.7
Delay discounting water rate 12 sec9.113.621.54.62.13.9
Delay discounting water rate 18 sec3.24.36.12.51.42.2
Delay discounting water rate 24 sec4.46.18.83.01.52.7
Delay discounting water rate 6 sec4.26.110.23.21.32.6
Locomotor activity2.03.25.82.40.81.8
Locomotor testing distance2.94.78.52.90.92.2
Locomotor testing rearing2.43.85.92.41.02.1
Light reinforcement 10.20.30.70.80.10.6
Light reinforcement 20.91.21.50.91.11.2
Reaction time number correct0.30.51.1-0.3-1.0-0.5
Reaction time mean minus median3.34.35.6-2.4-1.5-2.2
Reaction time mean minus median AUC1.72.12.4-1.5-1.3-1.6
Reaction time num false alarms0.30.40.90.90.00.5
Reaction time num false alarms AUC0.10.10.30.3-0.5-0.2
Reaction time trials correct on left0.30.51.1-0.3-1.0-0.5
Reaction time trials on left0.40.61.3-0.3-1.1-0.6
Reaction time mean0.00.10.1-0.30.1-0.3
Reaction time mean AUC0.10.10.1-0.40.2-0.2
Median of all reaction times0.10.10.20.00.50.2
Reaction time omissions1.21.61.8-1.3-1.1-1.3
Reaction time false alarm rate0.10.20.40.60.30.4
Reaction time premature initiation rate2.63.55.8-1.2-2.4-1.8
Reaction time premature initiations4.05.79.8-1.5-3.1-2.3
Std. dev. reaction times0.81.21.5-1.2-0.7-1.2
Reaction time trials completed0.40.61.3-0.3-1.1-0.6
Reaction time trials AUC0.20.40.9-0.2-0.9-0.4
Social response proportion1.01.11.4-1.1-0.9-1.2
Social responses0.30.40.7-0.2-0.8-0.6
Social time0.40.51.2-0.3-1.1-0.5
Conditioned locomotion1.72.12.4-1.3-1.5-1.5
Cocaine response after cond. corrected1.41.62.11.31.01.5
Cocaine response after cond. not corrected1.11.21.61.10.91.3
Cocaine response before conditioning0.60.81.0-0.9-0.7-1.0
Saline control response4.35.86.8-2.2-2.4-2.6
Condit. Reinf. active minus inactive responses0.20.20.50.00.70.4
Condit. Reinf. active-inactive response ratio0.80.91.90.11.40.9
Condit. Reinf. active responses0.10.10.2-0.40.3-0.2
Condit. Reinf. inactive responses0.20.30.4-0.6-0.5-0.6
Condit. Reinf. lever presses2.02.83.7-1.9-1.2-1.8
Condit. Reinf. lever reinforcers received0.20.30.5-0.7-0.1-0.6
Pavlov. Cond. lever latency0.50.71.11.10.40.8
Pavlov. Cond. magazine entry latency3.54.05.2-2.3-1.5-2.1
Pavlov. Cond. change in total contacts1.82.54.2-2.1-0.7-1.6
Pavlov. Cond. index score2.43.14.6-2.2-1.1-1.8
Pavlov. Cond. latency score2.02.54.0-2.0-0.9-1.6
Pavlov. Cond. lever contacts0.40.60.7-0.8-0.7-0.9
Pavlov. Cond. magazine entry number6.27.79.33.12.23.0
Pavlov. Cond. intertrial magazine entries1.21.51.81.21.11.4
Pavlov. Cond. lever-magazine prob. diff.2.93.75.3-2.3-1.3-2.0
Pavlov. Cond. response bias1.72.42.8-1.7-1.2-1.7
Conditioned reinforcement - actives0.30.20.40.40.40.6
Conditioned reinforcement - inactives6.37.17.32.72.62.7
Conditioned locomotion8.610.412.13.52.83.4
Intermittent access intake day 1-15 change0.70.71.31.10.50.8
Intermittent access intake escalation0.60.60.90.90.70.7
Intermittent access intake escalation 20.20.20.50.70.10.3
Intermitt. access day 1 inactive lever presses2.52.73.01.51.71.7
Intermitt. access day 15 inactive lever presses2.83.13.51.61.91.8
Intermitt. access escalation Index3.63.23.91.42.02.0
Intermittent access day 1 total infusions6.27.011.41.33.42.8
Intermittent access day 15 total infusions8.89.812.12.53.53.4
Intermittent access terminal intake (last 3 days)6.16.79.41.73.12.8
Intermittent access total infusions5.46.09.41.43.12.6
Intermittent access day 1 locomotion4.54.67.61.02.82.3
Intermittent access day 15 total locomotion5.55.87.71.92.82.5
Intermittent access total locomotion7.07.913.21.53.62.9
Intermittent access standard deviation1.31.41.71.31.01.3
Cocaine induced anxiety0.00.00.0-0.1-0.00.0
Post-drug Anxiety1.31.41.7-1.1-1.3-1.2
Baseline Anxiety2.62.73.3-1.3-1.8-1.8
Lifetime Intake4.75.38.41.22.92.4
Incentive Sensitization - Responses0.60.61.00.41.00.7
Incentive Sensitization - Breakpoint0.80.91.40.61.20.9
Progressive ratio test 1 active lever presses3.53.64.31.71.92.1
Progressive ratio test 1 breakpoint3.13.23.91.71.72.0
Progressive ratio test 1 inactive lever presses1.51.61.81.21.31.3
Progressive ratio test 2 active lever presses5.05.36.41.92.52.5
Progressive ratio test 2 breakpoint6.26.97.82.52.62.8
Progressive ratio test 2 inactive lever presses9.511.013.32.73.73.5
Total sessions with >9 infusions1.92.13.30.81.81.5
Short access day 1 total inactive lever presses4.04.55.41.82.32.2
Short access day 10 total inactive lever presses3.84.25.02.21.82.1
Short access day 1 total infusions3.33.56.10.82.52.0
Short access day 10 total infusions2.32.55.5-0.02.31.5
Short access total infusions1.81.93.60.31.91.5
Short access day 1 locomotion2.83.04.80.92.21.8
Short access day 10 total locomotion2.12.34.00.62.01.6
Short access total locomotion1.81.93.20.51.81.5
Compulsive drug intake2.92.94.9-0.8-2.2-1.8
One hour access (0.3 mA shock)11.112.914.83.33.63.8
One hour access (shock baseline)9.911.513.52.83.73.6
Number of responses in last shaping day1.61.62.31.50.81.4
Context. condit. distance diff. score1.92.32.61.41.51.6
Locomotion velocity, session 10.10.10.20.2-0.5-0.0
Locomotion distance, session 10.50.71.6-1.3-0.3-0.7
Locomotion velocity, session 22.93.44.9-2.2-1.4-1.8
Locomotion distance, session 20.60.91.7-1.3-0.6-0.8
Locomotion velocity, session 30.20.30.5-0.30.70.4
Locomotion distance, session 30.00.00.10.10.20.2
Stereotopy head waving bouts, day 30.40.50.90.11.00.8
Stereotopy head waving duration, day 30.60.71.00.41.00.9
Locomotion velocity, session 70.80.92.1-0.31.40.8
Locomotion distance, session 70.10.10.3-0.20.50.2
Stereotopy head waving bouts, day 70.20.30.6-0.20.80.4
Stereotopy head waving duration, day 71.01.22.4-1.5-0.4-1.1
Locomotion velocity, session 81.01.22.1-0.6-1.5-1.1
Locomotion distance, session 80.20.30.7-0.20.80.5
Degree of sensitization distance0.10.10.2-0.50.40.0
Degree of sensitization stereotypy0.50.51.1-1.0-0.2-0.7
Condit. Reinf. active minus inactive responses0.10.20.3-0.5-0.2-0.4
Condit. Reinf. active-inactive response ratio0.00.00.0-0.0-0.1-0.2
Condit. Reinf. active responses0.10.10.3-0.50.2-0.2
Condit. Reinf. inactive responses0.20.20.5-0.40.70.2
Incentive salience index mean0.40.41.0-1.0-0.1-0.6
Condit. Reinf. lever presses0.40.61.2-1.1-0.2-0.7
Time in familiar zone, hab. session 10.30.30.50.10.70.5
Time in novel zone, hab. session 10.30.30.80.9-0.20.3
Total zone transitions, hab. session 10.60.81.2-1.1-0.7-1.0
Total locomotion distance, hab. session 10.30.50.9-0.01.00.7
Locomotion velocity, hab. session 10.10.10.2-0.40.50.2
Time in familiar zone, hab. session 20.20.20.30.5-0.50.0
Time in novel zone, hab. session 20.20.20.4-0.60.2-0.2
Total zone transitions, hab. session 21.72.24.5-2.1-0.5-1.3
Total locomotion distance, hab. session 20.30.40.7-0.80.60.1
Locomotion velocity, hab. session 20.40.50.9-0.80.90.3
Novel to familiar place preference ratio1.11.21.9-1.4-0.5-1.1
Novelty place preference0.50.51.0-1.0-0.2-0.7
Time in novel zone, NPP test0.30.40.7-0.8-0.1-0.6
Total zone transitions, NPP test2.43.55.1-2.3-1.3-1.9
Total locomotion distance, NPP test0.20.20.6-0.80.2-0.2
Locomotion velocity, NPP test0.20.30.7-0.80.2-0.3
Pavlov. Cond. lever latency0.30.40.91.00.20.5
Pavlov. Cond. magazine entry latency0.30.41.2-1.10.2-0.4
Pavlov. Cond. change in total contacts0.20.20.5-0.70.4-0.2
Pavlov. Cond. index score0.10.20.4-0.6-0.1-0.4
Pavlov. Cond. latency score0.10.10.4-0.60.0-0.2
Pavlov. Cond. lever contacts0.00.00.1-0.40.1-0.1
Pavlov. Cond. magazine entry number0.20.20.30.60.30.5
Pavlov. Cond. intertrial magazine entries0.60.71.21.10.70.7
Pavlov. Cond. lever-magazine prob. diff.0.30.40.9-0.9-0.3-0.6
Pavlov. Cond. response bias0.10.10.2-0.4-0.1-0.3
Bone: apparent density0.61.02.4-1.60.2-0.7
Bone surface4.37.612.1-3.5-1.7-2.8
Bone volume1.62.85.8-2.4-0.5-1.5
Bone: connectivity density2.33.66.4-2.5-1.0-1.9
Bone: cortical apparent density0.20.30.4-0.2-0.6-0.6
Bone: cortical area0.60.91.1-1.1-0.8-1.0
Bone: cortical porosity0.20.20.4-0.60.1-0.3
Bone: cortical porosity0.70.71.1-1.0-0.5-0.9
Bone: cortical thickness2.54.16.2-1.3-2.5-2.1
Bone: cortical thickness0.70.81.8-0.0-1.3-0.7
Bone: cortical tissue density0.30.40.6-0.3-0.8-0.7
Bone: elastic displacement1.51.73.71.90.11.2
Bone: elastic work0.71.02.1-0.2-1.5-0.8
Bone: endosteal estimation0.91.93.9-0.12.01.3
Bone: endosteal perimeter1.22.45.00.02.21.5
Bone: final force3.25.26.4-2.5-1.8-2.4
Bone: final moment2.84.65.7-2.4-1.7-2.2
Bone: marrow area0.92.04.1-0.02.01.4
Bone: maximum diameter0.20.30.7-0.8-0.3-0.5
Bone: maximum force3.76.510.9-3.3-1.4-2.6
Bone: maximum moment3.25.59.4-3.1-1.3-2.3
Bone: minimum diameter1.01.94.0-0.22.01.2
Bone: periosteal estimation0.20.30.6-0.80.70.2
Bone: periosteal perimeter0.20.30.8-0.90.1-0.3
Bone: post-yield work2.53.47.8-2.81.4-0.7
Bone: stiffness3.14.88.4-2.9-1.1-2.2
Bone: tissue strength0.10.00.1-0.30.1-0.2
Bone: trabecular number0.61.02.3-1.50.1-0.8
Bone: trabecular spacing0.30.30.70.80.10.6
Bone: trabecular thickness0.60.71.50.21.20.8
Bone: trabecular tissue density3.54.95.52.32.02.3
Breakpoint value in progressive ratio session3.23.64.5-1.9-1.6-2.1
Distance traveled before self-admin0.60.71.0-1.0-0.5-0.8
Distance traveled after self-admin0.20.20.3-0.4-0.3-0.6
Delta time in closed arm before/after self-admin0.10.10.30.2-0.5-0.1
Delta time in open arm before/after self-admin0.00.00.1-0.2-0.1-0.3
Diff in mean of infusions in LGA sessions0.40.40.7-0.3-0.8-0.7
Extinction: sum of active levers before priming4.94.96.5-2.6-1.6-2.4
Active lever presses in extinction session 62.42.33.0-1.3-1.7-1.5
Delta distance traveled before/after self-admin0.10.10.20.5-0.10.1
Delta ambulatory time before/after self-admin0.10.10.20.4-0.3-0.0
Time in closed arm before self-admin0.10.10.2-0.50.2-0.2
Time in closed arm after self-admin0.00.00.00.00.20.0
Time in open arm before self-admin0.70.71.21.10.30.9
Time in open arm after self-admin0.30.30.80.9-0.00.5
Sum of active levers in priming session hrs 5-61.41.41.9-0.7-1.4-1.3
Time to tail flick, vehicle, before self-admin0.60.61.3-1.2-0.3-0.6
Time to tail flick, vehicle, after self-admin1.41.52.6-1.6-0.9-1.1
Time to tail flick, test, before self-admin0.80.81.50.11.20.9
Time to tail flick, test, after self-admin0.00.00.10.0-0.3-0.1
Delta time to tail flick, vehicle, before/after SA0.40.40.6-0.7-0.5-0.7
Delta time to tail flick, test, before/after SA1.71.53.2-0.2-1.8-1.1
Ambulatory time before self-admin0.40.50.8-0.9-0.3-0.7
Ambulatory time after self-admin0.10.20.4-0.20.70.1
Total heroin consumption5.76.98.0-2.6-2.4-2.8
Area under the delay curve0.10.10.2-0.20.50.3
Delay disc. indifference point, 0s delay0.50.50.90.20.81.0
Delay disc. indifference point, 16s delay1.01.01.90.61.40.9
Delay disc. indifference point, 2s delay0.10.10.20.00.50.4
Delay disc. indifference point, 24s delay0.10.10.30.5-0.10.3
Delay disc. indifference point, 4s delay0.10.10.30.20.40.5
Delay disc. indifference point, 8s delay0.00.00.10.00.10.3
Delay discount exponential model param0.10.10.10.1-0.4-0.3
Delay discount hyperbolic model param0.10.10.10.2-0.3-0.2
Fecal boli incidents, locomotor time 10.10.10.2-0.50.2-0.1
Change in fecal boli incidents, locomotor task0.00.00.0-0.1-0.2-0.1
Time >=10cm from walls, locomotor time 11.21.22.8-0.41.70.8
Bouts of movement, locomotor time 11.31.41.9-0.8-1.3-1.4
Total resting periods, locomotor time 10.91.01.4-0.8-0.9-1.2
Rest time, locomotor task time 11.31.51.91.40.81.4
Distance moved, locomotor task time 10.20.20.5-0.70.2-0.3
Vertical activity count, locomotor time 11.41.41.51.21.21.2
Time >=10cm from walls, locomotor time 20.10.10.2-0.50.1-0.1
Bouts of movement, locomotor time 20.50.50.9-0.5-0.6-0.9
Total resting periods, locomotor time 20.20.20.5-0.4-0.3-0.7
Rest time, locomotor task time 22.42.83.61.41.71.9
Distance moved, locomotor task time 21.11.21.5-0.9-1.2-1.2
Vertical activity count, locomotor time 20.40.40.80.9-0.70.0
Weight adjusted by age2.22.42.6-1.5-1.6-1.6
Seeking ratio, delayed vs. immediate footshock0.10.10.3-0.10.5-0.0
Locomotion in novel chamber4.75.86.72.12.52.6
Locomotion in novel chamber post-restriction3.23.84.11.82.02.0
Progressive ratio2.83.26.8-2.6-0.6-1.6
Food seeking constrained by brief footshock0.20.20.4-0.1-0.6-0.5
Seeking ratio, punishment vs. effort2.42.96.32.50.51.5
Run reversals in cocaine runway, females0.60.61.4-1.2-0.1-0.7
Run reversals in cocaine runway, males0.60.61.41.2-0.20.5
Latency to leave start box in cocaine runway0.20.20.5-0.50.70.0
Latency to leave start box in cocaine runway, F0.10.10.2-0.40.4-0.1
Latency to leave start box in cocaine runway, M0.00.00.1-0.20.2-0.0
Cd content in liver1.31.52.01.41.01.2
Co content in liver1.92.35.02.20.31.3
Cu content in liver0.20.30.5-0.7-0.2-0.5
Fe content in liver0.10.10.2-0.4-0.4-0.3
K content in liver1.91.93.7-1.9-0.6-1.3
Mg content in liver0.50.61.3-1.20.5-0.2
Mn content in liver2.52.93.4-1.8-1.4-1.8
Na content in liver1.21.31.4-1.1-1.2-1.1
Rb content in liver1.51.92.80.91.71.5
Se content in liver0.10.10.2-0.40.50.1
Sr content in liver3.43.14.3-1.1-2.1-1.9
Zn content in liver1.11.31.6-1.3-0.8-1.2