Hub : Genes

Pitpnm1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000018553	0.41	0.15	1.4e-13	0.08	0.11	0.11	0.1	4.0e-09	1.6e-12	7.3e-12	5.3e-11
2	Brain	gene expression	ENSRNOG00000018553	0.17	0.11	2.6e-10	0.1	0.08	0.13	0.12	6.5e-10	5.3e-08	1.9e-12	1.6e-11
3	IL	gene expression	ENSRNOG00000018553	0.25	0.16	8.7e-04	0.05	0.02	0.06	0.02	3.0e-02	1.4e-01	1.7e-02	1.1e-01
4	Liver	gene expression	ENSRNOG00000018553	0.27	0.13	0.0e+00	0.16	0.17	0.15	0.16	5.3e-17	4.6e-18	3.2e-16	4.0e-17
5	Liver	mRNA stability	ENSRNOG00000018553	0.02	0.02	4.2e-03	0.01	0.02	0.01	0.01	3.4e-02	6.7e-03	8.2e-03	1.5e-02
6	PL	gene expression	ENSRNOG00000018553	0.06	0.05	9.8e-04	0	0	0	-0	3.1e-01	3.0e-01	1.3e-01	4.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	0.9	2.9	6.9	-1.1	2.6	1.3	-0.8	-0.6	2.6
BMI without tail	0.5	1.0	2.3	-0.8	1.5	0.7	-0.4	-0.2	1.5
Body weight	0.9	3.6	12.0	-3.5	1.1	-1.2	1.7	2.0	0.6
Epididymis fat weight	1.3	3.0	8.4	2.9	-0.1	1.5	-1.8	-2.0	0.3
Glucose	2.7	4.2	5.4	2.3	1.1	2.3	-2.3	-2.3	1.6
Heart weight	0.9	1.2	2.8	1.7	0.3	1.1	-1.2	-1.3	0.4
Left kidney weight	0.2	0.5	1.5	1.2	-0.9	-0.1	-0.2	-0.3	-0.9
Right kidney weight	0.3	0.8	2.1	0.6	-1.2	-0.7	0.4	0.3	-1.5
Tail length	1.3	3.9	5.1	-2.3	-1.1	-2.1	2.2	2.2	-1.6
Length with tail	1.9	7.0	12.9	-3.6	-1.0	-2.7	3.0	3.1	-1.5
Length without tail	1.3	2.8	6.2	-2.5	-0.1	-1.6	1.9	2.0	-0.6
Liver weight, left	0.1	0.1	0.2	0.4	-0.4	0.2	-0.2	-0.2	0.1
Liver weight, right	0.2	0.3	0.6	-0.2	-0.5	-0.7	0.5	0.5	-0.7
Parametrial fat weight	1.7	3.4	5.5	2.3	0.9	2.0	-2.1	-2.1	1.2
Retroperitoneal fat weight	2.0	6.6	17.8	4.2	-0.1	2.3	-2.7	-3.0	0.4
Intraocular pressure	0.6	0.9	1.8	0.0	-1.3	-0.9	0.7	0.6	-1.3
Extensor digitorum longus weight	2.9	11.5	28.7	-5.4	-0.5	-3.1	3.7	4.0	-1.0
Soleus weight	0.7	2.0	7.0	2.6	-1.2	0.4	-0.9	-1.2	-1.2
Tibialis anterior weight	6.8	23.3	40.4	-6.4	-2.2	-5.0	5.4	5.6	-2.9
Tibia length	0.8	2.4	2.9	-1.2	-1.4	-1.7	1.6	1.6	-1.7
Number of licking bursts	0.1	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.3	0.3
Food consumed during 24 hour testing period	0.2	0.2	0.7	0.4	-0.8	-0.2	0.1	0.1	-0.5
Times rat made contact with spout	0.2	0.3	0.8	-0.3	0.6	0.5	-0.3	-0.2	0.9
Mean time between licks in bursts	0.4	0.6	1.5	-1.2	-0.2	-0.7	0.9	0.9	-0.2
Mean num. licks in bursts	0.1	0.2	0.6	-0.1	0.8	0.3	-0.2	-0.2	0.4
Std. dev. time between licks in bursts	1.8	2.2	2.7	-1.4	-1.1	-1.6	1.6	1.6	-1.4
Water consumed over 24 hours	0.1	0.1	0.4	-0.5	0.3	0.2	-0.0	0.1	0.6
Indifference point 0 sec	0.2	0.3	0.7	0.8	0.5	0.5	-0.6	-0.6	0.3
Indifference point AUC	1.2	1.4	2.5	-1.6	-0.3	-1.2	1.3	1.4	-0.8
Indifference point function ln k	1.3	1.8	5.3	2.3	-0.4	1.1	-1.4	-1.5	0.0
Indifference point function log k	1.3	1.8	5.3	2.3	-0.4	1.1	-1.4	-1.5	0.0
Delay discounting total patch changes 0 sec	0.0	0.0	0.1	0.3	0.1	-0.1	-0.0	-0.0	-0.2
Delay discounting total patch changes 12 sec	0.8	1.1	3.1	-1.8	0.3	-0.9	1.1	1.2	-0.1
Delay discounting total patch changes 18 sec	0.0	0.1	0.1	-0.3	0.3	-0.0	0.1	0.1	0.3
Delay discounting total patch changes 24 sec	0.8	1.0	1.8	-1.3	-0.5	-1.0	1.1	1.2	-0.7
Delay discounting total patch changes 6 sec	0.2	0.4	1.0	-0.5	1.0	0.3	-0.1	-0.0	0.8
Delay discounting time to switch 0 sec	1.1	1.6	4.1	-0.2	1.5	1.3	-1.0	-0.8	2.0
Delay discounting water rate 0 sec	1.3	2.0	5.6	1.0	-1.9	-1.1	0.7	0.4	-2.4
Delay discounting water rate 12 sec	1.6	2.4	5.9	1.6	-2.2	-0.9	0.4	0.2	-2.4
Delay discounting water rate 18 sec	0.3	0.4	0.9	0.9	-0.8	-0.0	-0.2	-0.3	-0.7
Delay discounting water rate 24 sec	1.0	1.4	3.4	0.5	-1.7	-1.1	0.8	0.6	-1.8
Delay discounting water rate 6 sec	1.1	1.5	3.4	0.3	-1.8	-1.1	0.9	0.7	-1.8
Locomotor activity	0.1	0.2	0.4	0.5	-0.4	-0.2	0.0	-0.0	-0.6
Locomotor testing distance	0.1	0.2	0.4	0.6	-0.6	-0.2	-0.1	-0.2	-0.6
Locomotor testing rearing	0.7	1.1	1.6	1.3	0.6	1.0	-1.2	-1.2	0.8
Light reinforcement 1	0.2	0.3	0.7	0.8	-0.7	0.1	-0.2	-0.3	-0.5
Light reinforcement 2	0.5	0.7	2.4	1.5	-0.6	0.3	-0.6	-0.7	-0.6
Reaction time number correct	1.0	1.4	1.7	-1.2	-1.0	-1.2	1.3	1.3	-1.0
Reaction time mean minus median	0.5	0.6	1.5	-1.2	1.2	-0.1	0.3	0.4	0.8
Reaction time mean minus median AUC	0.6	0.8	2.2	-1.5	0.5	-0.8	0.9	1.0	-0.0
Reaction time num false alarms	0.8	1.1	1.6	-0.7	-0.8	-1.2	1.1	1.1	-1.3
Reaction time num false alarms AUC	1.0	1.4	1.8	-1.3	-0.7	-1.3	1.4	1.4	-1.1
Reaction time trials correct on left	1.0	1.4	1.7	-1.2	-1.0	-1.2	1.3	1.3	-1.0
Reaction time trials on left	1.2	1.7	2.1	-1.3	-1.1	-1.4	1.4	1.5	-1.1
Reaction time mean	0.4	0.5	0.7	0.5	0.8	0.7	-0.7	-0.7	0.8
Reaction time mean AUC	0.5	0.7	0.8	0.6	0.9	0.8	-0.8	-0.8	0.9
Median of all reaction times	0.7	1.0	1.1	0.9	0.7	1.1	-1.1	-1.1	1.0
Reaction time omissions	0.9	1.1	2.9	-1.7	0.2	-1.0	1.2	1.2	-0.3
Reaction time false alarm rate	0.3	0.4	0.5	-0.5	-0.3	-0.7	0.7	0.7	-0.7
Reaction time premature initiation rate	1.2	1.6	4.2	-2.0	0.2	-1.1	1.3	1.4	-0.3
Reaction time premature initiations	2.8	4.0	8.3	-2.9	-0.4	-2.0	2.2	2.3	-1.0
Std. dev. reaction times	0.2	0.3	0.9	-0.5	0.9	0.1	-0.0	0.1	0.6
Reaction time trials completed	1.2	1.7	2.1	-1.3	-1.1	-1.4	1.4	1.5	-1.1
Reaction time trials AUC	0.9	1.2	1.5	-1.1	-1.0	-1.2	1.2	1.2	-1.0
Social response proportion	0.4	0.4	1.4	-0.7	1.2	0.2	-0.1	0.0	0.7
Social responses	0.5	0.7	1.3	-1.1	0.3	-0.8	0.9	0.9	-0.5
Social time	0.2	0.3	0.9	-1.0	0.3	-0.4	0.5	0.6	0.1
Conditioned locomotion	3.7	4.4	5.7	-2.3	-1.4	-2.2	2.4	2.4	-1.8
Cocaine response after cond. corrected	0.1	0.1	0.3	0.5	0.0	0.4	-0.4	-0.4	0.2
Cocaine response after cond. not corrected	0.5	0.5	0.7	0.7	0.5	0.8	-0.8	-0.8	0.7
Cocaine response before conditioning	0.1	0.2	0.4	-0.0	0.6	0.3	-0.3	-0.3	0.5
Saline control response	0.7	1.0	3.2	-1.8	0.1	-0.7	1.0	1.1	0.1
Condit. Reinf. active minus inactive responses	1.9	2.4	2.9	1.5	1.3	1.7	-1.7	-1.7	1.5
Condit. Reinf. active-inactive response ratio	1.9	2.0	3.3	1.8	0.6	1.5	-1.6	-1.7	1.0
Condit. Reinf. active responses	1.8	2.5	3.2	1.0	1.7	1.7	-1.6	-1.6	1.8
Condit. Reinf. inactive responses	0.5	0.6	1.6	-0.4	1.3	0.6	-0.5	-0.4	1.2
Condit. Reinf. lever presses	0.3	0.5	1.3	-0.4	0.9	0.6	-0.4	-0.3	1.1
Condit. Reinf. lever reinforcers received	1.6	2.2	3.3	0.8	1.7	1.6	-1.5	-1.4	1.8
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.1	-0.2
Pavlov. Cond. magazine entry latency	0.6	0.7	1.7	-1.2	1.1	0.3	-0.0	0.1	1.3
Pavlov. Cond. change in total contacts	0.4	0.5	1.2	0.1	0.8	0.8	-0.7	-0.6	1.1
Pavlov. Cond. index score	0.2	0.3	0.8	-0.5	0.6	0.4	-0.2	-0.1	0.9
Pavlov. Cond. latency score	0.2	0.2	0.6	-0.4	0.4	0.3	-0.2	-0.1	0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.3	0.3	-0.3
Pavlov. Cond. magazine entry number	0.8	1.0	2.1	1.4	-1.3	-0.4	0.0	-0.2	-1.4
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.5	1.2	-0.6	0.2	-0.5	-0.6	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.7	0.6	0.3	-0.1	0.0	0.9
Pavlov. Cond. response bias	0.1	0.2	0.4	-0.6	0.6	0.1	0.1	0.2	0.5
Conditioned reinforcement - actives	0.2	0.2	0.5	0.1	-0.3	-0.4	0.3	0.3	-0.7
Conditioned reinforcement - inactives	1.9	2.2	6.5	2.5	0.1	1.2	-1.5	-1.7	0.1
Conditioned locomotion	1.5	1.8	6.2	2.5	-1.0	0.3	-0.8	-1.1	-1.3
Intermittent access intake day 1-15 change	0.5	0.5	1.3	1.0	-1.2	0.1	-0.2	-0.3	-0.6
Intermittent access intake escalation	0.6	0.6	1.6	1.3	-0.8	0.5	-0.6	-0.7	-0.2
Intermittent access intake escalation 2	0.2	0.2	0.5	0.7	-0.7	0.0	-0.1	-0.2	-0.5
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.6	1.3	0.4	0.8	-1.0	-1.0	0.3
Intermitt. access day 15 inactive lever presses	1.5	1.7	3.5	1.9	0.1	1.3	-1.4	-1.5	0.7
Intermitt. access escalation Index	0.7	0.6	1.7	1.3	-1.0	0.3	-0.5	-0.6	-0.5
Intermittent access day 1 total infusions	6.8	7.7	9.5	3.0	1.9	2.9	-3.1	-3.1	2.4
Intermittent access day 15 total infusions	5.0	5.6	12.5	3.5	0.5	2.3	-2.6	-2.8	1.1
Intermittent access terminal intake (last 3 days)	4.8	5.2	9.7	3.1	0.8	2.3	-2.6	-2.7	1.4
Intermittent access total infusions	4.1	4.6	7.2	2.7	1.1	2.2	-2.4	-2.4	1.6
Intermittent access day 1 locomotion	4.3	4.4	5.1	1.9	1.9	2.1	-2.3	-2.2	2.1
Intermittent access day 15 total locomotion	2.8	3.0	6.4	2.5	0.5	1.7	-1.9	-2.0	0.8
Intermittent access total locomotion	6.2	7.0	11.3	3.4	1.3	2.7	-3.0	-3.1	1.8
Intermittent access standard deviation	0.3	0.3	1.0	1.0	-0.3	0.3	-0.5	-0.5	-0.1
Cocaine induced anxiety	0.0	0.0	0.0	0.2	0.2	0.1	0.0	-0.0	-0.1
Post-drug Anxiety	1.2	1.3	1.9	-1.4	-0.5	-1.2	1.3	1.3	-0.8
Baseline Anxiety	1.7	1.8	3.3	-1.8	-0.6	-1.3	1.5	1.5	-0.8
Lifetime Intake	3.6	4.0	5.9	2.4	1.2	2.0	-2.2	-2.3	1.5
Incentive Sensitization - Responses	0.2	0.2	0.4	0.6	0.2	0.5	-0.5	-0.5	0.2
Incentive Sensitization - Breakpoint	0.3	0.3	0.7	0.8	0.2	0.5	-0.6	-0.6	0.2
Progressive ratio test 1 active lever presses	0.4	0.4	1.4	1.2	0.3	0.4	-0.7	-0.8	-0.0
Progressive ratio test 1 breakpoint	0.3	0.3	0.9	1.0	0.2	0.2	-0.5	-0.6	-0.2
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.6	0.7	0.7	0.5	-0.7	-0.7	0.3
Progressive ratio test 2 active lever presses	1.3	1.4	3.6	1.9	0.3	1.0	-1.3	-1.4	0.3
Progressive ratio test 2 breakpoint	1.0	1.1	3.5	1.9	-0.1	0.7	-1.0	-1.1	-0.2
Progressive ratio test 2 inactive lever presses	4.5	5.2	11.6	3.4	0.8	2.2	-2.5	-2.7	1.0
Total sessions with >9 infusions	0.7	0.8	1.1	1.0	0.8	0.9	-1.0	-1.0	0.6
Short access day 1 total inactive lever presses	1.3	1.4	3.0	1.7	0.4	1.1	-1.4	-1.5	0.5
Short access day 10 total inactive lever presses	0.8	0.8	1.8	1.4	0.0	0.9	-1.0	-1.1	0.4
Short access day 1 total infusions	2.7	2.8	4.0	2.0	1.1	1.7	-1.9	-1.9	1.3
Short access day 10 total infusions	4.4	4.8	5.5	1.9	1.9	2.3	-2.4	-2.3	2.3
Short access total infusions	2.0	2.2	2.6	1.3	1.4	1.5	-1.6	-1.6	1.4
Short access day 1 locomotion	2.3	2.4	3.1	1.7	1.2	1.6	-1.7	-1.8	1.2
Short access day 10 total locomotion	1.3	1.5	1.8	1.1	1.1	1.2	-1.3	-1.3	1.1
Short access total locomotion	1.2	1.3	1.5	0.9	1.2	1.1	-1.2	-1.2	1.0
Compulsive drug intake	3.5	3.5	7.3	-2.7	-0.2	-1.9	2.1	2.2	-1.0
One hour access (0.3 mA shock)	3.5	4.1	10.4	3.2	0.5	1.8	-2.2	-2.3	0.5
One hour access (shock baseline)	4.1	4.7	12.8	3.6	0.2	1.9	-2.3	-2.5	0.5
Number of responses in last shaping day	0.1	0.1	0.3	0.6	0.3	0.0	-0.2	-0.2	-0.3
Context. condit. distance diff. score	0.7	0.8	1.7	1.3	0.1	0.9	-1.0	-1.1	0.4
Locomotion velocity, session 1	0.0	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0	0.0
Locomotion distance, session 1	0.9	1.1	2.3	0.1	1.2	1.1	-1.0	-0.9	1.5
Locomotion velocity, session 2	0.9	1.0	2.8	-1.7	0.1	-0.9	1.1	1.2	-0.1
Locomotion distance, session 2	0.2	0.3	0.6	-0.6	0.7	0.3	-0.1	0.0	0.8
Locomotion velocity, session 3	1.4	1.7	2.4	0.7	1.4	1.4	-1.3	-1.2	1.6
Locomotion distance, session 3	0.1	0.1	0.3	0.2	0.5	0.3	-0.3	-0.3	0.4
Stereotopy head waving bouts, day 3	1.7	2.1	2.6	1.2	1.1	1.6	-1.5	-1.5	1.6
Stereotopy head waving duration, day 3	1.5	1.8	2.4	1.6	0.6	1.5	-1.5	-1.5	1.1
Locomotion velocity, session 7	1.1	1.2	1.5	0.6	1.1	1.2	-1.1	-1.1	1.2
Locomotion distance, session 7	0.1	0.1	0.2	-0.4	0.5	0.1	-0.0	0.0	0.4
Stereotopy head waving bouts, day 7	1.8	2.0	2.5	1.4	1.1	1.6	-1.6	-1.6	1.4
Stereotopy head waving duration, day 7	1.0	1.2	2.4	0.1	1.3	1.2	-1.0	-0.9	1.6
Locomotion velocity, session 8	0.4	0.5	1.5	-1.2	0.2	-0.6	0.8	0.8	0.1
Locomotion distance, session 8	0.4	0.6	0.8	0.8	0.4	0.9	-0.9	-0.9	0.7
Degree of sensitization distance	0.1	0.1	0.4	-0.2	0.5	0.3	-0.2	-0.2	0.6
Degree of sensitization stereotypy	0.4	0.5	0.9	0.1	0.8	0.7	-0.6	-0.6	1.0
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	0.2	0.7	0.7	-0.5	-0.5	0.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.4	0.6	0.7	-0.6	-0.6	0.5
Condit. Reinf. active responses	0.0	0.1	0.1	0.1	0.4	0.3	-0.2	-0.2	0.2
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.0	-0.1	-0.2	0.1	0.1	-0.3
Incentive salience index mean	0.1	0.2	0.4	-0.0	0.6	0.4	-0.3	-0.3	0.5
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.3	-0.1	-0.3	0.3	0.3	-0.3
Time in familiar zone, hab. session 1	0.6	0.6	0.9	0.9	0.5	0.8	-0.9	-0.9	0.6
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	0.3	-0.3
Total zone transitions, hab. session 1	0.1	0.1	0.3	-0.6	0.5	0.0	0.1	0.2	0.3
Total locomotion distance, hab. session 1	0.4	0.5	0.9	1.0	0.4	0.7	-0.8	-0.8	0.4
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.5	0.2	0.4	-0.4	-0.4	0.2
Time in familiar zone, hab. session 2	1.2	1.2	1.5	-1.2	-0.7	-1.2	1.2	1.2	-1.0
Time in novel zone, hab. session 2	1.4	1.4	1.7	0.9	1.1	1.3	-1.2	-1.2	1.3
Total zone transitions, hab. session 2	2.0	2.6	5.5	0.0	2.1	1.7	-1.3	-1.2	2.3
Total locomotion distance, hab. session 2	1.3	1.7	2.5	0.8	1.3	1.5	-1.3	-1.3	1.6
Locomotion velocity, hab. session 2	1.4	2.0	2.4	1.1	1.3	1.6	-1.5	-1.4	1.5
Novel to familiar place preference ratio	0.3	0.3	0.6	0.1	0.6	0.6	-0.5	-0.5	0.8
Novelty place preference	0.5	0.5	0.7	0.4	0.6	0.8	-0.8	-0.7	0.9
Time in novel zone, NPP test	0.5	0.5	0.8	0.4	0.7	0.8	-0.7	-0.7	0.9
Total zone transitions, NPP test	0.4	0.5	1.3	-0.6	1.1	0.6	-0.3	-0.2	1.1
Total locomotion distance, NPP test	0.4	0.5	0.7	0.5	0.7	0.8	-0.7	-0.7	0.8
Locomotion velocity, NPP test	0.2	0.3	0.4	0.5	0.5	0.6	-0.6	-0.6	0.6
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.3	-0.2	-0.2	0.0	0.0	-0.3
Pavlov. Cond. magazine entry latency	1.2	1.5	1.9	0.9	1.1	1.4	-1.3	-1.3	1.3
Pavlov. Cond. change in total contacts	0.8	0.9	1.1	1.0	0.7	1.0	-1.0	-1.1	0.7
Pavlov. Cond. index score	0.0	0.1	0.1	0.3	-0.0	0.3	-0.3	-0.3	0.1
Pavlov. Cond. latency score	0.1	0.2	0.2	0.4	0.2	0.5	-0.4	-0.4	0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.0	0.1	0.2	-0.2	-0.2	0.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.3	0.2	-0.1	0.1	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.0	-0.8	-0.7	0.6	0.5	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.2	0.1	0.2	-0.2	-0.2	0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	0.3	0.0	0.3	-0.3	-0.3	0.0
Bone: apparent density	2.1	3.4	6.2	0.7	2.1	2.0	-1.7	-1.6	2.5
Bone surface	1.2	2.2	5.5	-0.7	2.0	1.3	-0.9	-0.7	2.4
Bone volume	1.4	2.4	4.8	0.3	1.8	1.6	-1.4	-1.2	2.2
Bone: connectivity density	1.5	2.4	5.9	-0.5	2.2	1.4	-1.0	-0.8	2.4
Bone: cortical apparent density	0.4	0.6	1.0	-1.0	-0.3	-0.8	0.8	0.9	-0.5
Bone: cortical area	0.8	1.2	1.5	-1.1	-0.9	-1.1	1.2	1.2	-0.9
Bone: cortical porosity	0.1	0.1	0.1	0.2	0.2	0.3	-0.3	-0.3	0.3
Bone: cortical porosity	0.1	0.1	0.3	-0.5	0.1	-0.2	0.3	0.3	0.1
Bone: cortical thickness	4.9	8.1	11.0	-3.3	-1.8	-3.0	3.2	3.3	-2.2
Bone: cortical thickness	1.9	2.2	3.6	-1.9	-0.8	-1.5	1.7	1.7	-1.0
Bone: cortical tissue density	0.6	0.7	1.3	-1.1	-0.3	-0.9	1.0	1.0	-0.5
Bone: elastic displacement	2.4	2.7	4.3	-0.8	-1.8	-1.8	1.6	1.5	-2.1
Bone: elastic work	2.5	3.3	4.2	-2.0	-1.3	-2.0	2.0	2.1	-1.4
Bone: endosteal estimation	1.9	4.2	5.4	2.3	1.3	2.2	-2.3	-2.3	1.7
Bone: endosteal perimeter	4.0	8.3	10.9	3.3	1.7	3.1	-3.2	-3.3	2.3
Bone: final force	0.3	0.5	1.7	-1.3	0.1	-0.3	0.5	0.7	0.5
Bone: final moment	0.3	0.4	1.5	-1.2	0.1	-0.3	0.5	0.6	0.4
Bone: marrow area	1.9	4.2	5.4	2.3	1.3	2.2	-2.3	-2.3	1.7
Bone: maximum diameter	0.0	0.0	0.1	0.3	-0.4	-0.1	0.0	-0.0	-0.3
Bone: maximum force	0.7	1.2	3.7	-0.6	1.3	1.0	-0.7	-0.5	1.9
Bone: maximum moment	0.6	1.0	3.0	-0.6	1.2	0.9	-0.6	-0.4	1.7
Bone: minimum diameter	2.5	4.6	5.5	2.0	1.7	2.3	-2.3	-2.3	2.1
Bone: periosteal estimation	0.1	0.3	0.4	0.6	0.2	0.5	-0.6	-0.6	0.4
Bone: periosteal perimeter	0.4	0.7	0.9	0.8	0.5	1.0	-0.9	-0.9	0.9
Bone: post-yield work	8.0	10.9	14.7	2.2	3.0	3.6	-3.5	-3.4	3.8
Bone: stiffness	1.0	1.6	3.9	-0.1	1.3	1.3	-1.0	-0.9	2.0
Bone: tissue strength	0.3	0.3	0.4	0.5	0.3	0.6	-0.6	-0.6	0.5
Bone: trabecular number	1.7	2.6	4.8	0.5	1.8	1.7	-1.5	-1.4	2.2
Bone: trabecular spacing	0.5	0.7	1.2	-0.2	-1.1	-0.8	0.7	0.6	-1.1
Bone: trabecular thickness	2.3	2.7	3.2	1.5	1.5	1.8	-1.7	-1.7	1.6
Bone: trabecular tissue density	1.0	1.3	4.0	2.0	-1.3	0.1	-0.6	-0.8	-1.2
Breakpoint value in progressive ratio session	0.5	0.6	2.0	-1.4	0.1	-0.5	0.7	0.8	0.3
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.1	-0.1	0.3
Distance traveled after self-admin	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	-0.2	0.2
Delta time in closed arm before/after self-admin	1.1	1.0	1.7	-1.3	-0.2	-1.1	1.1	1.2	-0.7
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.5	0.2	0.5	-0.5	-0.5	0.4
Diff in mean of infusions in LGA sessions	0.4	0.5	0.9	-0.7	-0.9	-0.5	0.7	0.7	-0.3
Extinction: sum of active levers before priming	0.7	0.7	2.5	-1.6	0.4	-0.3	0.6	0.7	0.7
Active lever presses in extinction session 6	2.2	2.2	3.0	-1.7	-0.8	-1.6	1.6	1.6	-1.2
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.1	0.1	-0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.3	0.3	-0.3
Time in closed arm before self-admin	0.3	0.3	0.5	0.7	0.3	0.6	-0.7	-0.7	0.5
Time in closed arm after self-admin	0.2	0.2	0.3	-0.5	-0.2	-0.6	0.5	0.5	-0.4
Time in open arm before self-admin	0.3	0.4	0.5	-0.7	-0.4	-0.6	0.7	0.7	-0.4
Time in open arm after self-admin	0.1	0.1	0.1	-0.1	-0.2	-0.2	0.3	0.3	-0.3
Sum of active levers in priming session hrs 5-6	3.3	3.2	4.1	-1.4	-1.6	-2.0	1.9	1.8	-2.0
Time to tail flick, vehicle, before self-admin	1.4	1.4	3.7	0.4	0.6	1.3	-1.2	-1.1	1.9
Time to tail flick, vehicle, after self-admin	0.6	0.6	2.0	-1.4	0.9	-0.3	0.5	0.7	0.4
Time to tail flick, test, before self-admin	1.9	1.9	2.7	0.9	1.4	1.4	-1.4	-1.4	1.7
Time to tail flick, test, after self-admin	0.2	0.2	0.9	-0.3	-1.0	-0.3	0.3	0.3	-0.1
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.4	-1.2	0.7	-0.7	0.9	0.9	-0.5
Delta time to tail flick, test, before/after SA	4.7	4.2	5.2	-1.6	-2.3	-2.1	2.1	2.1	-2.0
Ambulatory time before self-admin	0.1	0.1	0.3	0.2	-0.1	0.5	-0.4	-0.3	0.6
Ambulatory time after self-admin	1.4	1.5	2.0	1.3	0.5	1.4	-1.4	-1.4	1.1
Total heroin consumption	1.6	1.9	5.3	-2.3	-0.1	-1.2	1.4	1.6	-0.2
Area under the delay curve	1.0	1.0	1.6	0.7	0.7	1.1	-1.1	-1.1	1.3
Delay disc. indifference point, 0s delay	1.7	1.8	2.3	0.9	1.4	1.5	-1.4	-1.3	1.5
Delay disc. indifference point, 16s delay	1.0	1.1	2.3	1.5	0.1	1.0	-1.1	-1.2	0.6
Delay disc. indifference point, 2s delay	0.8	0.9	1.1	0.9	0.5	1.0	-1.1	-1.0	0.9
Delay disc. indifference point, 24s delay	0.4	0.4	0.5	-0.5	-0.7	-0.6	0.6	0.6	-0.5
Delay disc. indifference point, 4s delay	0.4	0.4	0.7	0.2	0.7	0.6	-0.6	-0.5	0.8
Delay disc. indifference point, 8s delay	0.3	0.3	0.7	0.3	0.3	0.6	-0.5	-0.5	0.8
Delay discount exponential model param	0.7	0.7	1.1	-0.5	-0.6	-0.9	0.9	0.8	-1.1
Delay discount hyperbolic model param	0.7	0.7	1.2	-0.5	-0.7	-0.9	0.9	0.8	-1.1
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.1	-0.2	0.1	-0.2	-0.2	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.3	0.4	0.1	-0.0	0.0	0.4
Time >=10cm from walls, locomotor time 1	4.2	4.2	5.0	2.1	1.7	2.2	-2.2	-2.2	1.8
Bouts of movement, locomotor time 1	1.2	1.3	1.7	-1.2	-0.9	-1.2	1.3	1.3	-0.8
Total resting periods, locomotor time 1	0.8	0.9	1.1	-0.9	-0.8	-1.1	1.1	1.1	-0.7
Rest time, locomotor task time 1	0.4	0.4	1.1	0.7	-1.1	-0.5	0.2	0.1	-0.9
Distance moved, locomotor task time 1	0.8	0.9	1.3	0.4	0.9	1.1	-1.0	-0.9	1.2
Vertical activity count, locomotor time 1	1.2	1.3	2.0	1.4	0.4	1.2	-1.3	-1.3	0.7
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.2	0.2	0.1	-0.1	0.1	0.1	-0.4
Bouts of movement, locomotor time 2	0.4	0.4	0.8	-0.9	0.0	-0.7	0.7	0.7	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.4	0.2	-0.3	0.3	0.3	0.0
Rest time, locomotor task time 2	2.0	2.3	4.3	2.1	0.5	1.5	-1.7	-1.7	1.0
Distance moved, locomotor task time 2	1.0	1.2	1.8	-1.3	-0.8	-1.1	1.2	1.2	-0.8
Vertical activity count, locomotor time 2	2.4	2.6	3.5	-1.3	-1.5	-1.7	1.7	1.6	-1.9
Weight adjusted by age	0.6	0.6	1.8	-1.3	0.1	-0.7	0.9	0.9	-0.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.4	0.3	0.7	0.9	-0.8	-0.7	1.2
Locomotion in novel chamber	3.3	4.0	9.9	3.1	0.1	1.9	-2.2	-2.3	0.6
Locomotion in novel chamber post-restriction	1.0	1.2	3.7	1.9	-0.2	0.9	-1.1	-1.2	-0.1
Progressive ratio	1.9	2.2	5.2	-0.3	2.0	1.4	-1.1	-0.9	2.3
Food seeking constrained by brief footshock	0.1	0.1	0.4	-0.6	0.0	-0.1	0.2	0.2	0.2
Seeking ratio, punishment vs. effort	1.2	1.5	3.3	0.2	-1.8	-1.1	0.8	0.7	-1.8
Run reversals in cocaine runway, females	0.8	0.8	1.8	-0.3	1.4	0.8	-0.6	-0.5	1.3
Run reversals in cocaine runway, males	1.2	1.2	1.3	-0.8	-1.0	-1.2	1.1	1.1	-1.1
Latency to leave start box in cocaine runway	1.2	1.3	1.7	0.9	0.9	1.3	-1.2	-1.2	1.3
Latency to leave start box in cocaine runway, F	0.7	0.7	1.1	0.6	0.6	1.0	-0.9	-0.9	1.0
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	0.2	0.2	-0.2	-0.2	0.2
Cd content in liver	0.3	0.4	1.2	1.1	-0.5	0.2	-0.4	-0.5	-0.5
Co content in liver	0.6	0.8	1.6	-0.2	-0.9	-1.0	0.8	0.7	-1.3
Cu content in liver	0.1	0.2	0.3	-0.5	-0.0	-0.5	0.5	0.5	-0.3
Fe content in liver	0.0	0.0	0.1	-0.3	0.2	-0.1	0.2	0.2	-0.1
K content in liver	0.7	0.7	1.7	-0.4	1.2	0.7	-0.5	-0.4	1.3
Mg content in liver	3.0	3.1	4.5	1.0	1.7	1.9	-1.8	-1.7	2.1
Mn content in liver	0.3	0.4	1.2	-1.1	0.5	-0.4	0.6	0.7	0.1
Na content in liver	0.5	0.5	0.7	-0.5	-0.8	-0.7	0.7	0.7	-0.8
Rb content in liver	3.5	4.3	5.1	2.0	1.7	2.2	-2.3	-2.3	2.0
Se content in liver	0.9	1.1	1.4	1.0	0.7	1.2	-1.2	-1.2	1.1
Sr content in liver	2.5	2.3	3.2	-1.8	-0.9	-1.6	1.7	1.7	-1.1
Zn content in liver	0.4	0.5	1.2	-1.1	-0.0	-0.7	0.7	0.8	-0.2