Hub : Genes

Fermt3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000021161 0.04 0.03 6.6e-03 0.03 0.02 0.02 0.02 6.4e-04 2.9e-03 5.4e-03 1.1e-03
2 BLA intron excision ratio chr1:204207062:204207496 0.1 0.06 4.4e-04 0.04 0.04 0.04 0.05 2.6e-03 2.2e-03 1.9e-03 1.4e-03
3 BLA intron excision ratio chr1:204207065:204207496 0.1 0.06 3.5e-04 0.04 0.05 0.05 0.05 1.9e-03 1.3e-03 9.7e-04 8.2e-04
4 Liver gene expression ENSRNOG00000021161 0.04 0.03 1.1e-03 0.01 0.01 0.01 0.01 1.5e-02 3.5e-02 1.7e-02 4.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail3.511.429.4-5.41.7-1.73.2
BMI without tail1.63.48.2-2.90.4-0.42.3
Body weight2.39.819.7-4.3-0.70.74.4
Epididymis fat weight2.25.27.8-0.32.8-2.8-2.3
Glucose2.94.56.9-0.72.6-2.6-1.9
Heart weight2.02.95.50.51.7-1.7-2.3
Left kidney weight0.31.01.30.21.1-1.1-1.2
Right kidney weight0.20.61.00.01.0-1.0-0.5
Tail length1.44.16.20.5-2.52.51.9
Length with tail1.45.18.9-1.0-2.32.33.0
Length without tail0.91.93.5-1.5-0.90.91.9
Liver weight, left0.50.91.3-1.21.0-1.0-0.3
Liver weight, right0.91.43.0-1.71.2-1.2-0.1
Parametrial fat weight2.85.59.0-1.03.0-3.0-1.8
Retroperitoneal fat weight3.812.718.10.34.0-4.0-4.3
Intraocular pressure0.91.34.52.1-0.30.3-0.7
Extensor digitorum longus weight3.614.632.3-3.9-2.32.35.7
Soleus weight2.05.913.81.02.1-2.1-3.7
Tibialis anterior weight5.619.343.5-2.9-3.63.66.6
Tibia length0.41.03.5-0.6-0.40.41.9
Number of licking bursts0.10.20.40.1-0.30.30.6
Food consumed during 24 hour testing period0.50.61.51.2-0.60.60.4
Times rat made contact with spout0.91.11.80.2-1.31.30.8
Mean time between licks in bursts0.81.11.9-0.2-1.41.40.6
Mean num. licks in bursts0.10.10.20.3-0.40.4-0.4
Std. dev. time between licks in bursts0.20.30.40.3-0.70.7-0.5
Water consumed over 24 hours1.61.92.90.8-1.71.71.1
Indifference point 0 sec0.00.00.10.20.1-0.1-0.4
Indifference point AUC2.12.45.3-0.8-1.41.42.3
Indifference point function ln k3.95.613.11.02.0-2.0-3.6
Indifference point function log k3.95.613.11.02.0-2.0-3.6
Delay discounting total patch changes 0 sec0.10.10.10.4-0.30.3-0.3
Delay discounting total patch changes 12 sec2.63.46.2-1.1-1.81.82.5
Delay discounting total patch changes 18 sec0.50.71.3-0.7-0.70.71.2
Delay discounting total patch changes 24 sec1.82.34.1-0.6-1.51.52.0
Delay discounting total patch changes 6 sec0.40.61.1-1.0-0.50.51.0
Delay discounting time to switch 0 sec1.21.94.8-2.20.6-0.61.3
Delay discounting water rate 0 sec1.93.06.42.50.1-0.1-2.3
Delay discounting water rate 12 sec3.45.19.93.10.6-0.6-3.2
Delay discounting water rate 18 sec1.01.33.40.80.7-0.7-1.9
Delay discounting water rate 24 sec1.21.73.51.50.7-0.7-1.9
Delay discounting water rate 6 sec1.52.25.11.90.4-0.4-2.3
Locomotor activity0.60.92.51.10.1-0.1-1.6
Locomotor testing distance0.81.33.81.10.2-0.2-2.0
Locomotor testing rearing0.91.43.41.00.8-0.8-1.8
Light reinforcement 10.20.40.80.9-0.40.4-0.5
Light reinforcement 21.21.62.30.51.4-1.4-1.5
Reaction time number correct0.40.60.90.1-0.90.90.7
Reaction time mean minus median1.62.05.6-1.4-0.60.62.4
Reaction time mean minus median AUC1.01.33.6-0.6-0.80.81.9
Reaction time num false alarms0.30.50.90.2-0.70.7-0.9
Reaction time num false alarms AUC0.50.61.2-0.1-1.11.1-0.1
Reaction time trials correct on left0.40.60.90.1-0.90.90.7
Reaction time trials on left0.50.71.10.1-1.01.00.8
Reaction time mean0.10.10.10.20.3-0.30.3
Reaction time mean AUC0.10.10.20.20.4-0.40.2
Median of all reaction times0.20.30.40.50.6-0.6-0.2
Reaction time omissions0.71.01.3-0.1-1.11.11.1
Reaction time false alarm rate0.10.20.6-0.2-0.20.2-0.8
Reaction time premature initiation rate1.82.43.2-0.8-1.81.81.7
Reaction time premature initiations3.44.97.0-0.5-2.72.72.3
Std. dev. reaction times0.30.41.3-0.4-0.30.31.1
Reaction time trials completed0.50.71.10.1-1.01.00.8
Reaction time trials AUC0.30.40.70.0-0.80.80.6
Social response proportion0.50.51.1-0.2-0.60.61.0
Social responses0.70.91.50.3-1.21.20.8
Social time0.40.50.7-0.0-0.70.70.9
Conditioned locomotion0.70.82.2-0.6-0.60.61.5
Cocaine response after cond. corrected0.80.91.3-0.21.1-1.1-1.1
Cocaine response after cond. not corrected0.70.71.0-0.51.0-1.0-0.9
Cocaine response before conditioning0.50.61.0-0.3-0.70.71.0
Saline control response2.83.76.2-1.2-1.91.92.5
Condit. Reinf. active minus inactive responses0.30.40.7-0.40.9-0.9-0.3
Condit. Reinf. active-inactive response ratio2.52.64.6-0.82.1-2.1-0.8
Condit. Reinf. active responses0.00.00.1-0.30.0-0.00.3
Condit. Reinf. inactive responses1.01.32.20.1-1.51.50.8
Condit. Reinf. lever presses0.81.13.1-1.0-0.40.41.7
Condit. Reinf. lever reinforcers received0.10.20.5-0.2-0.30.30.7
Pavlov. Cond. lever latency0.30.40.80.9-0.20.2-0.9
Pavlov. Cond. magazine entry latency2.12.55.5-1.1-1.31.32.4
Pavlov. Cond. change in total contacts0.50.72.6-0.6-0.10.11.6
Pavlov. Cond. index score1.11.44.0-1.1-0.40.42.0
Pavlov. Cond. latency score0.91.23.2-1.2-0.20.21.8
Pavlov. Cond. lever contacts0.20.30.8-0.2-0.40.40.9
Pavlov. Cond. magazine entry number2.93.59.11.21.4-1.4-3.0
Pavlov. Cond. intertrial magazine entries0.40.51.10.40.6-0.6-1.1
Pavlov. Cond. lever-magazine prob. diff.1.31.74.9-1.1-0.70.62.2
Pavlov. Cond. response bias0.81.13.0-0.6-0.70.71.7
Conditioned reinforcement - actives0.30.30.50.20.6-0.6-0.7
Conditioned reinforcement - inactives3.43.96.32.11.5-1.5-2.5
Conditioned locomotion4.95.912.02.31.8-1.8-3.5
Intermittent access intake day 1-15 change0.50.51.61.3-0.10.1-0.7
Intermittent access intake escalation0.40.41.01.00.1-0.1-0.7
Intermittent access intake escalation 20.40.41.31.1-0.30.3-0.3
Intermitt. access day 1 inactive lever presses1.61.72.80.81.3-1.3-1.7
Intermitt. access day 15 inactive lever presses2.42.73.90.91.7-1.7-2.0
Intermitt. access escalation Index1.51.32.70.61.1-1.1-1.6
Intermittent access day 1 total infusions8.19.114.2-0.93.8-3.8-2.7
Intermittent access day 15 total infusions7.28.010.90.53.3-3.3-3.2
Intermittent access terminal intake (last 3 days)6.97.511.9-0.23.5-3.5-2.5
Intermittent access total infusions6.77.411.5-0.63.4-3.4-2.5
Intermittent access day 1 locomotion6.46.510.2-1.13.2-3.2-2.1
Intermittent access day 15 total locomotion3.74.05.40.42.3-2.3-2.2
Intermittent access total locomotion8.59.615.5-0.63.9-3.9-2.7
Intermittent access standard deviation0.70.81.61.00.6-0.6-1.2
Cocaine induced anxiety0.10.10.2-0.30.4-0.40.3
Post-drug Anxiety0.40.41.2-0.4-0.30.31.1
Baseline Anxiety1.61.72.2-0.4-1.51.51.5
Lifetime Intake6.16.810.6-0.73.3-3.3-2.4
Incentive Sensitization - Responses0.60.60.90.01.0-1.0-0.7
Incentive Sensitization - Breakpoint0.80.81.20.21.1-1.1-0.9
Progressive ratio test 1 active lever presses2.42.54.10.81.6-1.6-2.0
Progressive ratio test 1 breakpoint2.02.03.30.91.4-1.4-1.8
Progressive ratio test 1 inactive lever presses0.50.61.20.60.6-0.6-1.1
Progressive ratio test 2 active lever presses4.04.35.70.62.3-2.3-2.4
Progressive ratio test 2 breakpoint4.04.57.61.22.1-2.1-2.8
Progressive ratio test 2 inactive lever presses5.56.49.61.22.7-2.7-3.1
Total sessions with >9 infusions3.64.06.3-0.92.5-2.5-1.6
Short access day 1 total inactive lever presses3.43.86.60.92.0-2.0-2.6
Short access day 10 total inactive lever presses1.82.04.71.30.9-0.9-2.2
Short access day 1 total infusions4.14.36.5-0.52.5-2.5-2.0
Short access day 10 total infusions5.66.19.4-1.73.1-3.1-1.7
Short access total infusions3.94.36.6-1.32.6-2.6-1.5
Short access day 1 locomotion3.43.65.7-0.72.4-2.4-1.6
Short access day 10 total locomotion2.02.13.3-0.31.8-1.8-1.4
Short access total locomotion2.62.74.2-0.72.0-2.0-1.3
Compulsive drug intake4.64.68.00.3-2.82.81.5
One hour access (0.3 mA shock)6.87.913.51.22.9-2.9-3.7
One hour access (shock baseline)7.68.811.61.13.3-3.3-3.4
Number of responses in last shaping day0.50.51.20.80.3-0.3-1.1
Context. condit. distance diff. score0.91.12.30.01.1-1.0-1.5
Locomotion velocity, session 10.20.20.5-0.70.3-0.3-0.0
Locomotion distance, session 10.91.13.3-1.80.7-0.70.4
Locomotion velocity, session 21.11.33.0-1.4-0.50.51.7
Locomotion distance, session 20.30.41.3-1.10.1-0.10.7
Locomotion velocity, session 33.54.15.4-2.12.3-2.3-0.8
Locomotion distance, session 30.30.40.6-0.70.7-0.7-0.3
Stereotopy head waving bouts, day 32.83.44.3-2.02.1-2.1-1.0
Stereotopy head waving duration, day 31.21.52.1-0.71.4-1.4-1.1
Locomotion velocity, session 72.12.32.7-1.61.6-1.6-1.1
Locomotion distance, session 70.60.81.8-1.30.7-0.7-0.6
Stereotopy head waving bouts, day 70.60.61.2-0.31.1-1.1-0.4
Stereotopy head waving duration, day 70.30.41.3-0.60.0-0.01.1
Locomotion velocity, session 80.30.40.8-0.6-0.50.50.9
Locomotion distance, session 81.31.92.4-1.51.6-1.6-0.6
Degree of sensitization distance0.70.71.4-1.20.8-0.8-0.3
Degree of sensitization stereotypy0.10.10.4-0.30.2-0.20.6
Condit. Reinf. active minus inactive responses0.10.10.1-0.3-0.40.40.4
Condit. Reinf. active-inactive response ratio0.30.40.60.6-0.70.70.2
Condit. Reinf. active responses0.10.10.3-0.50.3-0.30.0
Condit. Reinf. inactive responses1.01.21.6-1.11.3-1.3-0.5
Incentive salience index mean0.20.30.8-0.9-0.00.00.6
Condit. Reinf. lever presses0.40.51.3-1.10.3-0.30.7
Time in familiar zone, hab. session 10.20.20.3-0.50.3-0.3-0.4
Time in novel zone, hab. session 10.20.20.40.60.2-0.2-0.5
Total zone transitions, hab. session 10.20.30.7-0.4-0.30.30.8
Total locomotion distance, hab. session 10.91.32.0-1.01.4-1.4-0.7
Locomotion velocity, hab. session 10.30.40.6-0.80.8-0.8-0.2
Time in familiar zone, hab. session 20.40.40.80.1-0.90.90.1
Time in novel zone, hab. session 20.20.20.4-0.10.7-0.70.1
Total zone transitions, hab. session 21.01.33.7-1.90.3-0.31.1
Total locomotion distance, hab. session 21.01.42.8-1.71.2-1.2-0.2
Locomotion velocity, hab. session 21.31.82.8-1.71.4-1.4-0.4
Novel to familiar place preference ratio0.40.51.7-0.3-0.00.01.3
Novelty place preference0.20.20.90.00.1-0.10.9
Time in novel zone, NPP test0.20.20.7-0.10.2-0.20.8
Total zone transitions, NPP test1.01.43.1-1.5-0.30.31.8
Total locomotion distance, NPP test0.60.81.8-1.30.9-0.9-0.0
Locomotion velocity, NPP test0.30.41.0-1.00.6-0.60.1
Pavlov. Cond. lever latency0.20.30.60.80.1-0.1-0.8
Pavlov. Cond. magazine entry latency0.20.30.5-0.70.3-0.30.7
Pavlov. Cond. change in total contacts0.10.10.10.00.3-0.30.3
Pavlov. Cond. index score0.20.20.40.1-0.40.40.7
Pavlov. Cond. latency score0.10.10.3-0.2-0.20.20.5
Pavlov. Cond. lever contacts0.10.10.3-0.5-0.00.00.3
Pavlov. Cond. magazine entry number0.30.40.6-0.60.6-0.6-0.8
Pavlov. Cond. intertrial magazine entries0.70.92.51.6-0.30.3-0.9
Pavlov. Cond. lever-magazine prob. diff.0.30.30.9-0.1-0.50.50.9
Pavlov. Cond. response bias0.10.20.30.2-0.40.40.6
Bone: apparent density0.81.33.1-1.80.9-0.90.8
Bone surface2.23.98.4-2.60.3-0.32.9
Bone volume1.32.14.2-2.10.9-0.91.6
Bone: connectivity density1.32.04.1-2.00.1-0.12.0
Bone: cortical apparent density1.01.32.20.8-1.51.50.5
Bone: cortical area0.30.41.2-0.7-0.10.11.1
Bone: cortical porosity0.00.00.1-0.3-0.10.10.1
Bone: cortical porosity0.30.40.5-0.5-0.60.60.7
Bone: cortical thickness2.84.66.90.1-2.62.62.2
Bone: cortical thickness0.70.81.4-0.3-1.21.20.7
Bone: cortical tissue density1.21.62.60.9-1.61.60.6
Bone: elastic displacement1.01.12.21.5-0.50.5-1.3
Bone: elastic work0.81.11.8-0.3-1.31.30.9
Bone: endosteal estimation3.47.311.2-2.33.4-3.4-1.2
Bone: endosteal perimeter4.28.714.2-2.13.8-3.8-1.4
Bone: final force1.62.65.3-2.2-0.30.32.3
Bone: final moment1.32.24.6-2.0-0.20.22.2
Bone: marrow area3.47.411.2-2.33.3-3.3-1.3
Bone: maximum diameter0.50.91.1-0.91.0-1.00.7
Bone: maximum force2.74.812.4-3.50.7-0.72.4
Bone: maximum moment2.34.110.6-3.20.7-0.72.2
Bone: minimum diameter2.74.97.7-1.72.8-2.8-1.1
Bone: periosteal estimation1.63.24.5-2.02.1-2.1-0.0
Bone: periosteal perimeter0.91.51.9-1.41.4-1.40.4
Bone: post-yield work5.37.311.4-3.43.0-3.00.4
Bone: stiffness1.93.07.7-2.80.3-0.32.1
Bone: tissue strength0.00.00.0-0.1-0.00.0-0.1
Bone: trabecular number0.61.01.7-1.30.8-0.80.9
Bone: trabecular spacing0.40.50.60.5-0.70.7-0.7
Bone: trabecular thickness0.81.01.6-0.11.3-1.3-0.9
Bone: trabecular tissue density1.62.25.21.50.8-0.8-2.3
Breakpoint value in progressive ratio session1.51.73.6-0.5-1.21.21.9
Distance traveled before self-admin0.10.10.5-0.4-0.10.10.7
Distance traveled after self-admin0.30.30.50.7-0.50.50.4
Delta time in closed arm before/after self-admin0.10.10.5-0.7-0.20.2-0.2
Delta time in open arm before/after self-admin0.50.50.90.9-0.60.60.6
Diff in mean of infusions in LGA sessions0.70.81.20.4-1.11.10.8
Extinction: sum of active levers before priming2.22.25.5-1.2-1.01.02.3
Active lever presses in extinction session 61.41.42.7-0.2-1.21.21.6
Delta distance traveled before/after self-admin0.10.10.30.6-0.30.3-0.1
Delta ambulatory time before/after self-admin0.10.10.30.5-0.30.3-0.0
Time in closed arm before self-admin0.10.10.2-0.40.3-0.30.4
Time in closed arm after self-admin0.20.20.4-0.60.4-0.4-0.5
Time in open arm before self-admin0.30.30.70.4-0.40.4-0.9
Time in open arm after self-admin1.11.22.21.5-1.11.1-0.1
Sum of active levers in priming session hrs 5-61.31.21.50.7-1.21.21.2
Time to tail flick, vehicle, before self-admin1.51.52.5-1.61.1-1.11.1
Time to tail flick, vehicle, after self-admin1.81.94.1-2.0-0.20.21.8
Time to tail flick, test, before self-admin1.91.92.5-1.41.6-1.6-0.8
Time to tail flick, test, after self-admin0.10.10.10.2-0.20.20.3
Delta time to tail flick, vehicle, before/after SA0.50.50.7-0.8-0.60.60.8
Delta time to tail flick, test, before/after SA3.53.14.11.6-2.02.01.2
Ambulatory time before self-admin0.10.10.3-0.20.1-0.10.6
Ambulatory time after self-admin0.20.30.40.60.6-0.6-0.3
Total heroin consumption3.54.27.6-0.9-2.12.02.8
Area under the delay curve0.30.30.4-0.70.6-0.60.1
Delay disc. indifference point, 0s delay1.01.11.4-1.21.2-1.2-0.4
Delay disc. indifference point, 16s delay0.60.60.90.50.7-0.7-1.0
Delay disc. indifference point, 2s delay0.60.61.1-0.51.1-1.1-0.1
Delay disc. indifference point, 24s delay0.20.20.40.3-0.60.6-0.0
Delay disc. indifference point, 4s delay0.10.10.3-0.60.2-0.20.0
Delay disc. indifference point, 8s delay0.20.20.4-0.70.3-0.30.1
Delay discount exponential model param0.20.20.30.6-0.40.4-0.2
Delay discount hyperbolic model param0.20.30.50.7-0.50.5-0.2
Fecal boli incidents, locomotor time 10.10.10.2-0.30.3-0.30.4
Change in fecal boli incidents, locomotor task0.30.31.1-1.00.3-0.3-0.3
Time >=10cm from walls, locomotor time 14.14.16.6-1.62.6-2.6-0.7
Bouts of movement, locomotor time 14.95.48.32.0-2.92.91.1
Total resting periods, locomotor time 13.74.16.21.8-2.52.50.9
Rest time, locomotor task time 10.70.81.71.2-0.00.0-1.3
Distance moved, locomotor task time 10.60.61.3-1.10.7-0.70.5
Vertical activity count, locomotor time 11.41.52.30.11.5-1.5-1.2
Time >=10cm from walls, locomotor time 20.10.10.10.40.2-0.20.3
Bouts of movement, locomotor time 20.80.91.50.6-1.21.20.6
Total resting periods, locomotor time 20.40.40.60.5-0.80.80.4
Rest time, locomotor task time 22.12.53.9-0.11.7-1.7-2.0
Distance moved, locomotor task time 21.21.41.80.0-1.41.41.3
Vertical activity count, locomotor time 20.60.71.10.8-1.11.1-0.0
Weight adjusted by age1.21.43.3-0.6-1.00.91.8
Seeking ratio, delayed vs. immediate footshock0.10.10.20.3-0.20.2-0.5
Locomotion in novel chamber3.24.06.10.82.2-2.2-2.5
Locomotion in novel chamber post-restriction2.02.34.50.71.5-1.5-2.1
Progressive ratio1.41.63.9-2.00.2-0.21.6
Food seeking constrained by brief footshock0.10.10.1-0.1-0.40.40.3
Seeking ratio, punishment vs. effort1.11.32.81.7-0.20.2-1.5
Run reversals in cocaine runway, females1.11.14.0-2.00.3-0.30.4
Run reversals in cocaine runway, males0.00.00.10.3-0.10.1-0.2
Latency to leave start box in cocaine runway0.70.81.3-0.71.1-1.1-0.4
Latency to leave start box in cocaine runway, F0.10.10.1-0.00.3-0.30.0
Latency to leave start box in cocaine runway, M1.01.01.4-1.01.2-1.2-0.5
Cd content in liver0.60.70.80.80.9-0.9-0.6
Co content in liver1.92.25.62.4-1.01.0-1.1
Cu content in liver0.20.30.50.5-0.40.40.7
Fe content in liver0.40.40.6-0.80.6-0.60.7
K content in liver1.81.84.8-2.20.4-0.41.4
Mg content in liver1.01.12.0-1.41.1-1.10.2
Mn content in liver0.91.02.8-0.8-0.60.61.7
Na content in liver0.40.51.1-0.8-0.30.31.0
Rb content in liver1.41.82.4-0.61.6-1.6-1.4
Se content in liver0.20.30.50.30.7-0.70.2
Sr content in liver2.82.53.30.6-1.81.81.8
Zn content in liver0.40.41.2-0.0-0.50.51.1