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Incentive salience index mean

Terminal incentive salience index, average of daily incentive salience index for days 4 and 5

Tags: Behavior · Motivation

Project: p50_shelly_flagel_2014

2 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 144900859 146298381 1 1 1.9e-07 0.0041 0.0613 58 Rap2b
2 5 137682119 138752373 1 1 5.5e-09 0.1255 0.0016 -323 Stk40

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 4.3 1 0 0 0 1 Stk40
BMI without tail 4.6 1 0 0 0 1 Stk40
Body weight 4.0 1 0 0 0 1 Stk40
Glucose 24.2 1 1 50 0 1 Stk40
Left kidney weight 2.0 1 0 0 0 1 Stk40
Tail length 3.3 1 0 0 0 1 Stk40
Extensor digitorum longus weight 4.1 2 0 0 0 1 Stk40 Rap2b
Soleus weight 14.0 1 1 50 0 1 Stk40
Tibialis anterior weight 1.8 1 0 0 0 1 Stk40
Number of licking bursts 7.6 1 0 0 0 1 Rap2b
Times rat made contact with spout 8.1 1 0 0 0 1 Rap2b
Mean time between licks in bursts 11.1 1 0 0 0 1 Rap2b
Std. dev. time between licks in bursts 10.8 1 0 0 0 1 Rap2b
Water consumed over 24 hours 7.5 1 0 0 0 1 Rap2b
Indifference point AUC 6.3 1 0 0 0 1 Stk40
Delay discounting total patch changes 0 sec 3.3 1 0 0 0 1 Stk40
Delay discounting total patch changes 18 sec 6.9 1 0 0 0 1 Stk40
Locomotor testing distance 3.7 1 0 0 0 1 Rap2b
Locomotor testing rearing 15.0 1 0 0 0 1 Stk40
Reaction time number correct 4.4 1 0 0 0 1 Stk40
Reaction time mean minus median AUC 4.4 1 0 0 0 1 Rap2b
Reaction time num false alarms 5.6 1 0 0 0 1 Stk40
Reaction time num false alarms AUC 11.5 1 0 0 0 1 Stk40
Reaction time trials correct on left 4.4 1 0 0 0 1 Stk40
Reaction time trials on left 4.7 1 0 0 0 1 Stk40
Reaction time mean AUC 4.7 1 0 0 0 1 Rap2b
Reaction time omissions 4.8 1 0 0 0 1 Rap2b
Reaction time premature initiations 4.2 1 0 0 0 1 Stk40
Std. dev. reaction times 5.2 1 0 0 0 1 Rap2b
Reaction time trials completed 4.7 1 0 0 0 1 Stk40
Reaction time trials AUC 5.6 1 0 0 0 1 Stk40
Conditioned locomotion 5.3 1 0 0 0 1 Stk40
Cocaine response before conditioning 6.6 1 0 0 0 1 Stk40
Condit. Reinf. lever presses 6.5 2 0 0 0 1 Stk40 Rap2b
Short access day 10 total inactive lever presses 6.3 1 0 0 0 1 Stk40
Number of responses in last shaping day 5.5 1 0 0 0 1 Stk40
Context. condit. distance diff. score 11.6 1 0 0 0 1 Rap2b
Locomotion distance, session 2 3.9 1 0 0 0 1 Rap2b
Locomotion distance, session 3 5.1 1 0 0 0 1 Rap2b
Condit. Reinf. active minus inactive responses 16.3 2 0 0 0 1 Stk40 Rap2b
Condit. Reinf. active-inactive response ratio 13.9 2 0 0 0 1 Stk40 Rap2b
Condit. Reinf. active responses 11.0 2 0 0 0 1 Stk40 Rap2b
Condit. Reinf. lever presses 16.5 2 1 50 0 1 Stk40 Rap2b
Total zone transitions, hab. session 1 4.7 1 0 0 0 1 Rap2b
Total locomotion distance, hab. session 1 7.0 1 0 0 0 1 Rap2b
Locomotion velocity, hab. session 1 10.1 1 0 0 0 1 Rap2b
Novelty place preference 5.9 1 0 0 0 1 Stk40
Time in novel zone, NPP test 5.5 1 0 0 0 1 Stk40
Locomotion velocity, NPP test 4.1 1 0 0 0 1 Rap2b
Pavlov. Cond. lever latency 9.3 2 0 0 0 1 Stk40 Rap2b
Pavlov. Cond. magazine entry latency 8.5 1 0 0 0 1 Stk40
Pavlov. Cond. change in total contacts 8.9 1 0 0 0 1 Stk40
Pavlov. Cond. index score 9.4 1 0 0 0 1 Stk40
Pavlov. Cond. latency score 7.6 1 0 0 0 1 Stk40
Pavlov. Cond. lever contacts 10.6 1 0 0 0 1 Stk40
Pavlov. Cond. intertrial magazine entries 9.3 2 0 0 0 1 Stk40 Rap2b
Pavlov. Cond. lever-magazine prob. diff. 11.1 1 0 0 0 1 Stk40
Pavlov. Cond. response bias 7.8 1 0 0 0 1 Stk40
Bone: apparent density 13.8 2 0 0 0 1 Stk40 Rap2b
Bone surface 11.8 2 1 50 0 1 Stk40 Rap2b
Bone volume 17.9 2 1 50 0 1 Stk40 Rap2b
Bone: connectivity density 9.0 2 0 0 0 1 Stk40 Rap2b
Bone: cortical apparent density 4.3 1 0 0 0 1 Rap2b
Bone: cortical porosity 8.7 1 0 0 0 1 Rap2b
Bone: cortical porosity 6.3 1 0 0 0 1 Rap2b
Bone: cortical tissue density 4.9 1 0 0 0 1 Rap2b
Bone: endosteal estimation 6.6 1 0 0 0 1 Stk40
Bone: endosteal perimeter 3.0 1 0 0 0 1 Stk40
Bone: marrow area 6.2 1 0 0 0 1 Stk40
Bone: maximum diameter 3.3 2 0 0 0 1 Stk40 Rap2b
Bone: minimum diameter 3.5 1 0 0 0 1 Stk40
Bone: periosteal estimation 3.7 1 0 0 0 1 Stk40
Bone: periosteal perimeter 7.1 1 0 0 0 1 Stk40
Bone: post-yield work 3.8 1 0 0 0 1 Rap2b
Bone: trabecular number 13.4 2 1 50 0 1 Stk40 Rap2b
Bone: trabecular spacing 14.0 1 0 0 0 1 Rap2b
Bone: trabecular thickness 25.8 1 1 50 0 1 Rap2b
Bone: trabecular tissue density 4.1 1 0 0 0 1 Stk40
Extinction: sum of active levers before priming 6.6 1 0 0 0 1 Rap2b
Time to tail flick, vehicle, after self-admin 9.4 1 0 0 0 1 Rap2b
Rest time, locomotor task time 1 5.4 1 0 0 0 1 Stk40
Vertical activity count, locomotor time 1 5.0 1 0 0 0 1 Stk40
Seeking ratio, punishment vs. effort 6.5 1 0 0 0 1 Rap2b
Cd content in liver 8.3 1 0 0 0 1 Stk40
Co content in liver 7.0 1 0 0 0 1 Rap2b
Cu content in liver 4.8 1 0 0 0 1 Stk40
Fe content in liver 6.1 1 0 0 0 1 Rap2b
Mg content in liver 13.7 1 0 0 0 1 Stk40
Se content in liver 9.7 2 0 0 0 1 Stk40 Rap2b
Sr content in liver 132.4 1 1 50 0 1 Stk40

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.21
Adipose alternative TSS 0 0.000 1.17
Adipose gene expression 0 0.000 1.22
Adipose isoform ratio 0 0.000 1.20
Adipose intron excision ratio 0 0.000 1.18
Adipose mRNA stability 0 0.000 1.23
BLA alternative polyA 0 0.000 1.18
BLA alternative TSS 0 0.000 1.01
BLA gene expression 0 0.000 1.24
BLA isoform ratio 0 0.000 1.14
BLA intron excision ratio 0 0.000 1.19
BLA mRNA stability 0 0.000 1.26
Brain alternative polyA 0 0.000 1.17
Brain alternative TSS 0 0.000 1.03
Brain gene expression 0 0.000 1.23
Brain isoform ratio 0 0.000 1.19
Brain intron excision ratio 0 0.000 1.22
Brain mRNA stability 0 0.000 1.23
Eye alternative polyA 0 0.000 1.09
Eye alternative TSS 0 0.000 1.22
Eye gene expression 0 0.000 1.14
Eye isoform ratio 0 0.000 1.23
Eye intron excision ratio 0 0.000 1.17
Eye mRNA stability 0 0.000 1.54
IL alternative polyA 0 0.000 1.12
IL alternative TSS 0 0.000 1.01
IL gene expression 0 0.000 1.17
IL isoform ratio 0 0.000 1.12
IL intron excision ratio 0 0.000 1.36
IL mRNA stability 0 0.000 1.39
LHb alternative polyA 0 0.000 1.12
LHb alternative TSS 0 0.000 1.10
LHb gene expression 0 0.000 1.24
LHb isoform ratio 0 0.000 1.19
LHb intron excision ratio 0 0.000 1.25
LHb mRNA stability 0 0.000 1.37
Liver alternative polyA 0 0.000 1.30
Liver alternative TSS 0 0.000 1.17
Liver gene expression 1 0.014 1.17
Liver isoform ratio 0 0.000 1.19
Liver intron excision ratio 0 0.000 1.17
Liver mRNA stability 1 0.041 1.20
NAcc alternative polyA 0 0.000 1.17
NAcc alternative TSS 0 0.000 1.03
NAcc gene expression 0 0.000 1.23
NAcc isoform ratio 0 0.000 1.18
NAcc intron excision ratio 0 0.000 1.23
NAcc mRNA stability 0 0.000 1.28
OFC alternative polyA 0 0.000 1.09
OFC alternative TSS 0 0.000 0.99
OFC gene expression 0 0.000 1.19
OFC isoform ratio 0 0.000 1.28
OFC intron excision ratio 0 0.000 1.33
OFC mRNA stability 0 0.000 1.27
PL alternative polyA 0 0.000 1.21
PL alternative TSS 0 0.000 1.04
PL gene expression 0 0.000 1.22
PL isoform ratio 0 0.000 1.18
PL intron excision ratio 0 0.000 1.23
PL mRNA stability 0 0.000 1.23

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.