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Incentive salience index mean

Terminal incentive salience index, average of daily incentive salience index for days 4 and 5

Tags: Behavior · Motivation

Project: p50_shelly_flagel_2014

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	2	144900859	146298381	1	1	1.86e-07	4.08e-03	6.13e-02	Rap2b
2	5	137682119	138752373	1	1	5.46e-09	1.25e-01	1.62e-03	Stk40

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	4.29	1	0	0	0	1e+00	Stk40
BMI without tail	4.6	1	0	0	0	1e+00	Stk40
Body weight	4.02	1	0	0	0	1e+00	Stk40
Glucose	24.16	1	1	50	0	1e+00	Stk40
Left kidney weight	1.96	1	0	0	0	1e+00	Stk40
Tail length	3.34	1	0	0	0	1e+00	Stk40
Extensor digitorum longus weight	4.09	2	0	0	0	1e+00	Stk40 Rap2b
Soleus weight	14.02	1	1	50	0	1e+00	Stk40
Tibialis anterior weight	1.81	1	0	0	0	1e+00	Stk40
Number of licking bursts	7.6	1	0	0	0	1e+00	Rap2b
Times rat made contact with spout	8.11	1	0	0	0	1e+00	Rap2b
Mean time between licks in bursts	11.11	1	0	0	0	1e+00	Rap2b
Std. dev. time between licks in bursts	10.79	1	0	0	0	1e+00	Rap2b
Water consumed over 24 hours	7.55	1	0	0	0	1e+00	Rap2b
Indifference point AUC	6.34	1	0	0	0	1e+00	Stk40
Delay discounting total patch changes 0 sec	3.33	1	0	0	0	1e+00	Stk40
Delay discounting total patch changes 18 sec	6.87	1	0	0	0	1e+00	Stk40
Locomotor testing distance	3.73	1	0	0	0	1e+00	Rap2b
Locomotor testing rearing	15	1	0	0	0	1e+00	Stk40
Reaction time number correct	4.38	1	0	0	0	1e+00	Stk40
Reaction time mean minus median AUC	4.44	1	0	0	0	1e+00	Rap2b
Reaction time num false alarms	5.63	1	0	0	0	1e+00	Stk40
Reaction time num false alarms AUC	11.52	1	0	0	0	1e+00	Stk40
Reaction time trials correct on left	4.38	1	0	0	0	1e+00	Stk40
Reaction time trials on left	4.71	1	0	0	0	1e+00	Stk40
Reaction time mean AUC	4.72	1	0	0	0	1e+00	Rap2b
Reaction time omissions	4.8	1	0	0	0	1e+00	Rap2b
Reaction time premature initiations	4.23	1	0	0	0	1e+00	Stk40
Std. dev. reaction times	5.24	1	0	0	0	1e+00	Rap2b
Reaction time trials completed	4.71	1	0	0	0	1e+00	Stk40
Reaction time trials AUC	5.59	1	0	0	0	1e+00	Stk40
Conditioned locomotion	5.32	1	0	0	0	1e+00	Stk40
Cocaine response before conditioning	6.62	1	0	0	0	1e+00	Stk40
Condit. Reinf. lever presses	6.52	2	0	0	0	1e+00	Stk40 Rap2b
Short access day 10 total inactive lever presses	6.32	1	0	0	0	1e+00	Stk40
Number of responses in last shaping day	5.54	1	0	0	0	1e+00	Stk40
Context. condit. distance diff. score	11.58	1	0	0	0	1e+00	Rap2b
Locomotion distance, session 2	3.9	1	0	0	0	1e+00	Rap2b
Locomotion distance, session 3	5.06	1	0	0	0	1e+00	Rap2b
Condit. Reinf. active minus inactive responses	16.3	2	0	0	0	1e+00	Stk40 Rap2b
Condit. Reinf. active-inactive response ratio	13.93	2	0	0	0	1e+00	Stk40 Rap2b
Condit. Reinf. active responses	10.96	2	0	0	0	1e+00	Stk40 Rap2b
Condit. Reinf. lever presses	16.52	2	1	50	0	1e+00	Stk40 Rap2b
Total zone transitions, hab. session 1	4.73	1	0	0	0	1e+00	Rap2b
Total locomotion distance, hab. session 1	6.97	1	0	0	0	1e+00	Rap2b
Locomotion velocity, hab. session 1	10.08	1	0	0	0	1e+00	Rap2b
Novelty place preference	5.87	1	0	0	0	1e+00	Stk40
Time in novel zone, NPP test	5.48	1	0	0	0	1e+00	Stk40
Locomotion velocity, NPP test	4.09	1	0	0	0	1e+00	Rap2b
Pavlov. Cond. lever latency	9.3	2	0	0	0	1e+00	Stk40 Rap2b
Pavlov. Cond. magazine entry latency	8.53	1	0	0	0	1e+00	Stk40
Pavlov. Cond. change in total contacts	8.91	1	0	0	0	1e+00	Stk40
Pavlov. Cond. index score	9.42	1	0	0	0	1e+00	Stk40
Pavlov. Cond. latency score	7.62	1	0	0	0	1e+00	Stk40
Pavlov. Cond. lever contacts	10.64	1	0	0	0	1e+00	Stk40
Pavlov. Cond. intertrial magazine entries	9.29	2	0	0	0	1e+00	Stk40 Rap2b
Pavlov. Cond. lever-magazine prob. diff.	11.11	1	0	0	0	1e+00	Stk40
Pavlov. Cond. response bias	7.79	1	0	0	0	1e+00	Stk40
Bone: apparent density	13.76	2	0	0	0	1e+00	Stk40 Rap2b
Bone surface	11.85	2	1	50	0	1e+00	Stk40 Rap2b
Bone volume	17.86	2	1	50	0	1e+00	Stk40 Rap2b
Bone: connectivity density	9	2	0	0	0	1e+00	Stk40 Rap2b
Bone: cortical apparent density	4.26	1	0	0	0	1e+00	Rap2b
Bone: cortical porosity	8.71	1	0	0	0	1e+00	Rap2b
Bone: cortical porosity	6.35	1	0	0	0	1e+00	Rap2b
Bone: cortical tissue density	4.88	1	0	0	0	1e+00	Rap2b
Bone: endosteal estimation	6.58	1	0	0	0	1e+00	Stk40
Bone: endosteal perimeter	3.03	1	0	0	0	1e+00	Stk40
Bone: marrow area	6.24	1	0	0	0	1e+00	Stk40
Bone: maximum diameter	3.34	2	0	0	0	1e+00	Stk40 Rap2b
Bone: minimum diameter	3.45	1	0	0	0	1e+00	Stk40
Bone: periosteal estimation	3.68	1	0	0	0	1e+00	Stk40
Bone: periosteal perimeter	7.08	1	0	0	0	1e+00	Stk40
Bone: post-yield work	3.83	1	0	0	0	1e+00	Rap2b
Bone: trabecular number	13.43	2	1	50	0	1e+00	Stk40 Rap2b
Bone: trabecular spacing	13.96	1	0	0	0	1e+00	Rap2b
Bone: trabecular thickness	25.8	1	1	50	0	1e+00	Rap2b
Bone: trabecular tissue density	4.1	1	0	0	0	1e+00	Stk40
Extinction: sum of active levers before priming	6.6	1	0	0	0	1e+00	Rap2b
Time to tail flick, vehicle, after self-admin	9.36	1	0	0	0	1e+00	Rap2b
Rest time, locomotor task time 1	5.42	1	0	0	0	1e+00	Stk40
Vertical activity count, locomotor time 1	5.05	1	0	0	0	1e+00	Stk40
Seeking ratio, punishment vs. effort	6.54	1	0	0	0	1e+00	Rap2b
Cd content in liver	8.27	1	0	0	0	1e+00	Stk40
Co content in liver	7.05	1	0	0	0	1e+00	Rap2b
Cu content in liver	4.78	1	0	0	0	1e+00	Stk40
Fe content in liver	6.07	1	0	0	0	1e+00	Rap2b
Mg content in liver	13.66	1	0	0	0	1e+00	Stk40
Se content in liver	9.66	2	0	0	0	1e+00	Stk40 Rap2b
Sr content in liver	132.45	1	1	50	0	1e+00	Stk40

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.21
Adipose	alternative TSS	0	0	1.17
Adipose	gene expression	0	0	1.22
Adipose	isoform ratio	0	0	1.2
Adipose	intron excision ratio	0	0	1.18
Adipose	mRNA stability	0	0	1.23
BLA	alternative polyA	0	0	1.18
BLA	alternative TSS	0	0	1.01
BLA	gene expression	0	0	1.24
BLA	isoform ratio	0	0	1.14
BLA	intron excision ratio	0	0	1.19
BLA	mRNA stability	0	0	1.26
Brain	alternative polyA	0	0	1.17
Brain	alternative TSS	0	0	1.03
Brain	gene expression	0	0	1.23
Brain	isoform ratio	0	0	1.19
Brain	intron excision ratio	0	0	1.22
Brain	mRNA stability	0	0	1.23
Eye	alternative polyA	0	0	1.09
Eye	alternative TSS	0	0	1.22
Eye	gene expression	0	0	1.14
Eye	isoform ratio	0	0	1.23
Eye	intron excision ratio	0	0	1.17
Eye	mRNA stability	0	0	1.54
IL	alternative polyA	0	0	1.12
IL	alternative TSS	0	0	1.01
IL	gene expression	0	0	1.17
IL	isoform ratio	0	0	1.12
IL	intron excision ratio	0	0	1.36
IL	mRNA stability	0	0	1.39
LHb	alternative polyA	0	0	1.12
LHb	alternative TSS	0	0	1.1
LHb	gene expression	0	0	1.24
LHb	isoform ratio	0	0	1.19
LHb	intron excision ratio	0	0	1.25
LHb	mRNA stability	0	0	1.37
Liver	alternative polyA	0	0	1.3
Liver	alternative TSS	0	0	1.17
Liver	gene expression	1	0	1.17
Liver	isoform ratio	0	0	1.19
Liver	intron excision ratio	0	0	1.17
Liver	mRNA stability	1	0	1.2
NAcc	alternative polyA	0	0	1.17
NAcc	alternative TSS	0	0	1.03
NAcc	gene expression	0	0	1.23
NAcc	isoform ratio	0	0	1.18
NAcc	intron excision ratio	0	0	1.23
NAcc	mRNA stability	0	0	1.28
OFC	alternative polyA	0	0	1.09
OFC	alternative TSS	0	0	0.99
OFC	gene expression	0	0	1.19
OFC	isoform ratio	0	0	1.28
OFC	intron excision ratio	0	0	1.33
OFC	mRNA stability	0	0	1.27
PL	alternative polyA	0	0	1.21
PL	alternative TSS	0	0	1.04
PL	gene expression	0	0	1.22
PL	isoform ratio	0	0	1.18
PL	intron excision ratio	0	0	1.23
PL	mRNA stability	0	0	1.23