Hub : Genes

AC126581.1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000058291 0.07 0.05 1.0e-03 0.06 0.04 0.04 0.05 5.9e-04 2.8e-03 3.6e-03 1.2e-03
2 Brain gene expression ENSRNOG00000058291 0.04 0.03 4.4e-04 0.04 0.04 0.04 0 5.1e-05 2.3e-04 2.3e-04 3.4e-01
3 Liver gene expression ENSRNOG00000058291 0.07 0.06 2.1e-04 0.03 0.03 0.02 0.03 3.5e-04 4.8e-04 8.8e-04 6.9e-04
4 PL gene expression ENSRNOG00000058291 0.04 0.03 2.6e-03 0.02 0.02 0.02 0.02 7.0e-03 6.2e-03 1.3e-02 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.20.60.90.70.30.9-1.0
BMI without tail0.10.10.30.2-0.00.3-0.6
Body weight1.46.111.4-2.0-2.2-2.0-3.4
Epididymis fat weight3.06.98.42.42.92.42.8
Glucose3.65.55.72.42.32.42.4
Heart weight2.84.14.71.82.21.92.2
Left kidney weight0.10.40.90.40.60.51.0
Right kidney weight0.00.10.4-0.30.6-0.00.2
Tail length2.26.67.8-2.7-2.4-2.8-2.3
Length with tail3.010.912.9-3.2-3.0-3.3-3.6
Length without tail1.83.96.2-1.7-1.7-1.8-2.5
Liver weight, left0.00.00.10.1-0.3-0.10.1
Liver weight, right0.00.00.1-0.3-0.3-0.20.0
Parametrial fat weight3.67.07.42.72.52.72.6
Retroperitoneal fat weight4.615.319.83.74.03.54.4
Intraocular pressure0.20.30.90.21.00.20.5
Extensor digitorum longus weight4.718.829.4-3.8-4.0-3.9-5.4
Soleus weight1.44.19.21.61.41.63.0
Tibialis anterior weight9.934.244.8-5.3-5.9-5.4-6.7
Tibia length0.82.33.1-1.5-1.5-1.4-1.8
Number of licking bursts0.00.10.1-0.1-0.0-0.2-0.4
Food consumed during 24 hour testing period0.10.10.3-0.2-0.6-0.4-0.2
Times rat made contact with spout0.10.10.2-0.1-0.2-0.2-0.4
Mean time between licks in bursts0.71.01.2-1.0-1.0-1.1-0.8
Mean num. licks in bursts0.10.10.20.40.20.40.5
Std. dev. time between licks in bursts0.70.91.3-1.0-1.1-1.0-0.5
Water consumed over 24 hours0.30.30.7-0.4-0.4-0.5-0.8
Indifference point 0 sec0.40.61.00.81.00.60.5
Indifference point AUC2.22.64.3-1.4-1.5-1.3-2.1
Indifference point function ln k2.84.08.91.51.71.43.0
Indifference point function log k2.84.08.91.51.71.43.0
Delay discounting total patch changes 0 sec0.00.00.10.20.3-0.00.1
Delay discounting total patch changes 12 sec1.62.14.8-1.0-1.1-1.1-2.2
Delay discounting total patch changes 18 sec0.10.10.30.20.40.3-0.6
Delay discounting total patch changes 24 sec1.72.13.5-1.4-1.2-1.3-1.9
Delay discounting total patch changes 6 sec0.20.31.0-0.2-0.4-0.3-1.0
Delay discounting time to switch 0 sec0.10.20.50.4-0.10.3-0.7
Delay discounting water rate 0 sec0.60.92.40.21.00.31.6
Delay discounting water rate 12 sec1.11.75.50.41.00.52.3
Delay discounting water rate 18 sec0.60.82.20.50.60.51.5
Delay discounting water rate 24 sec0.60.82.30.20.90.31.5
Delay discounting water rate 6 sec0.30.41.3-0.20.4-0.21.1
Locomotor activity0.20.20.5-0.30.5-0.30.7
Locomotor testing distance0.20.30.9-0.30.5-0.31.0
Locomotor testing rearing0.81.32.30.81.01.01.5
Light reinforcement 10.10.10.20.10.40.10.4
Light reinforcement 20.70.91.30.81.10.71.1
Reaction time number correct0.71.01.4-1.0-0.6-1.2-1.0
Reaction time mean minus median0.81.12.8-0.9-0.5-0.7-1.7
Reaction time mean minus median AUC1.31.62.8-1.3-0.8-1.2-1.7
Reaction time num false alarms0.60.81.2-1.1-0.9-1.0-0.4
Reaction time num false alarms AUC1.21.72.4-1.5-1.2-1.3-1.0
Reaction time trials correct on left0.71.01.4-1.0-0.6-1.2-1.0
Reaction time trials on left0.91.21.7-1.2-0.7-1.3-1.2
Reaction time mean0.00.00.10.10.20.20.0
Reaction time mean AUC0.10.10.10.30.40.40.2
Median of all reaction times0.20.20.20.50.50.50.5
Reaction time omissions1.11.52.6-1.3-0.8-1.2-1.6
Reaction time false alarm rate0.30.40.7-0.8-0.8-0.6-0.2
Reaction time premature initiation rate2.43.33.9-1.9-1.5-1.8-2.0
Reaction time premature initiations4.66.57.5-2.7-2.1-2.6-2.7
Std. dev. reaction times0.20.30.8-0.5-0.1-0.3-0.9
Reaction time trials completed0.91.21.7-1.2-0.7-1.3-1.2
Reaction time trials AUC0.60.91.3-1.0-0.5-1.1-1.0
Social response proportion0.10.10.2-0.1-0.20.0-0.5
Social responses0.30.40.6-0.7-0.8-0.4-0.7
Social time0.70.91.6-0.8-1.3-0.8-0.8
Conditioned locomotion2.73.23.6-1.7-1.8-1.8-1.9
Cocaine response after cond. corrected0.40.40.80.50.70.30.9
Cocaine response after cond. not corrected0.50.60.90.60.80.51.0
Cocaine response before conditioning0.00.00.10.0-0.20.1-0.4
Saline control response1.62.13.6-1.2-1.5-1.2-1.9
Condit. Reinf. active minus inactive responses1.31.61.91.31.41.31.0
Condit. Reinf. active-inactive response ratio1.71.81.91.41.31.41.3
Condit. Reinf. active responses1.11.52.01.31.41.30.7
Condit. Reinf. inactive responses0.30.30.40.70.60.7-0.0
Condit. Reinf. lever presses0.30.41.3-0.2-0.4-0.2-1.2
Condit. Reinf. lever reinforcers received0.60.91.21.11.11.10.4
Pavlov. Cond. lever latency0.10.10.30.00.30.00.6
Pavlov. Cond. magazine entry latency0.70.82.2-0.5-0.7-0.6-1.5
Pavlov. Cond. change in total contacts0.10.20.60.3-0.00.3-0.7
Pavlov. Cond. index score0.40.51.4-0.3-0.7-0.3-1.2
Pavlov. Cond. latency score0.40.41.2-0.3-0.7-0.3-1.1
Pavlov. Cond. lever contacts0.20.30.5-0.4-0.7-0.3-0.7
Pavlov. Cond. magazine entry number1.41.74.30.81.10.82.1
Pavlov. Cond. intertrial magazine entries0.60.81.20.61.00.71.1
Pavlov. Cond. lever-magazine prob. diff.0.50.71.8-0.4-0.8-0.4-1.4
Pavlov. Cond. response bias0.40.51.3-0.3-0.7-0.4-1.1
Conditioned reinforcement - actives0.00.00.10.20.20.10.3
Conditioned reinforcement - inactives4.14.66.42.02.12.02.5
Conditioned locomotion2.83.46.91.51.51.52.6
Intermittent access intake day 1-15 change0.00.00.00.1-0.0-0.10.2
Intermittent access intake escalation0.10.10.10.30.20.30.3
Intermittent access intake escalation 20.10.10.1-0.3-0.3-0.4-0.1
Intermitt. access day 1 inactive lever presses2.02.22.71.51.31.41.6
Intermitt. access day 15 inactive lever presses1.71.92.21.51.31.21.4
Intermitt. access escalation Index3.93.54.61.81.71.92.1
Intermittent access day 1 total infusions10.311.612.33.43.43.53.4
Intermittent access day 15 total infusions7.88.810.02.92.92.93.2
Intermittent access terminal intake (last 3 days)6.87.47.72.72.72.72.8
Intermittent access total infusions7.58.38.92.92.93.02.8
Intermittent access day 1 locomotion7.27.48.42.72.72.92.6
Intermittent access day 15 total locomotion5.66.06.32.42.42.52.5
Intermittent access total locomotion11.012.513.53.63.53.73.4
Intermittent access standard deviation0.30.30.50.40.50.50.7
Cocaine induced anxiety0.00.00.1-0.3-0.2-0.2-0.2
Post-drug Anxiety1.82.02.3-1.4-1.3-1.4-1.5
Baseline Anxiety2.52.73.4-1.6-1.5-1.6-1.8
Lifetime Intake6.87.68.42.82.82.92.6
Incentive Sensitization - Responses0.80.80.91.01.00.90.8
Incentive Sensitization - Breakpoint1.01.01.11.01.00.90.9
Progressive ratio test 1 active lever presses2.42.53.11.41.61.51.8
Progressive ratio test 1 breakpoint1.81.82.41.11.41.31.6
Progressive ratio test 1 inactive lever presses1.21.31.61.21.11.11.3
Progressive ratio test 2 active lever presses4.24.44.92.12.12.02.2
Progressive ratio test 2 breakpoint3.53.95.21.81.91.82.3
Progressive ratio test 2 inactive lever presses9.110.512.53.13.23.13.5
Total sessions with >9 infusions2.42.63.01.51.61.71.6
Short access day 1 total inactive lever presses3.74.15.31.91.91.92.3
Short access day 10 total inactive lever presses1.31.42.71.11.00.91.6
Short access day 1 total infusions6.16.57.02.52.52.62.5
Short access day 10 total infusions6.37.08.72.72.72.92.2
Short access total infusions3.53.84.71.92.02.21.8
Short access day 1 locomotion4.75.05.62.42.22.32.1
Short access day 10 total locomotion3.84.14.92.11.92.21.8
Short access total locomotion3.43.54.11.91.82.01.7
Compulsive drug intake5.04.95.6-2.4-2.2-2.2-2.1
One hour access (0.3 mA shock)6.98.111.02.72.62.63.3
One hour access (shock baseline)8.59.911.43.13.03.03.4
Number of responses in last shaping day0.20.20.60.30.40.40.8
Context. condit. distance diff. score1.11.32.21.01.01.11.5
Locomotion velocity, session 10.40.40.6-0.8-0.6-0.8-0.3
Locomotion distance, session 10.10.10.30.30.60.4-0.1
Locomotion velocity, session 21.11.22.3-0.9-1.0-0.9-1.5
Locomotion distance, session 20.10.10.4-0.3-0.3-0.2-0.6
Locomotion velocity, session 30.30.40.40.60.60.70.5
Locomotion distance, session 30.00.00.00.10.10.20.1
Stereotopy head waving bouts, day 30.91.01.21.00.91.01.1
Stereotopy head waving duration, day 31.31.61.91.31.11.21.4
Locomotion velocity, session 71.01.11.41.11.11.20.9
Locomotion distance, session 70.00.00.00.10.10.10.0
Stereotopy head waving bouts, day 71.41.62.11.41.21.41.0
Stereotopy head waving duration, day 70.40.40.80.90.50.9-0.1
Locomotion velocity, session 81.21.51.6-1.2-1.2-1.2-1.3
Locomotion distance, session 80.30.40.50.50.60.60.7
Degree of sensitization distance0.10.10.10.30.10.30.1
Degree of sensitization stereotypy0.30.30.50.70.50.7-0.1
Condit. Reinf. active minus inactive responses0.00.00.00.0-0.0-0.1-0.1
Condit. Reinf. active-inactive response ratio0.00.00.10.20.20.10.1
Condit. Reinf. active responses0.00.00.0-0.0-0.1-0.1-0.2
Condit. Reinf. inactive responses0.00.00.00.20.10.20.1
Incentive salience index mean0.00.00.10.0-0.1-0.1-0.3
Condit. Reinf. lever presses0.20.20.3-0.4-0.4-0.5-0.5
Time in familiar zone, hab. session 10.70.60.70.80.80.80.8
Time in novel zone, hab. session 10.30.30.4-0.5-0.7-0.6-0.1
Total zone transitions, hab. session 10.30.40.7-0.7-0.4-0.5-0.9
Total locomotion distance, hab. session 10.30.40.60.50.60.60.7
Locomotion velocity, hab. session 10.00.10.10.10.30.20.3
Time in familiar zone, hab. session 20.70.70.9-0.9-1.0-0.9-0.5
Time in novel zone, hab. session 20.60.60.90.80.90.90.4
Total zone transitions, hab. session 20.71.01.71.01.31.10.0
Total locomotion distance, hab. session 21.11.42.01.21.41.20.9
Locomotion velocity, hab. session 21.41.92.71.31.61.41.1
Novel to familiar place preference ratio0.10.10.20.40.20.4-0.3
Novelty place preference0.30.30.50.70.50.70.0
Time in novel zone, NPP test0.30.30.50.70.50.70.1
Total zone transitions, NPP test0.30.41.1-0.5-0.3-0.4-1.0
Total locomotion distance, NPP test0.00.10.10.20.30.20.2
Locomotion velocity, NPP test0.00.00.10.10.30.10.1
Pavlov. Cond. lever latency0.00.00.10.10.10.00.2
Pavlov. Cond. magazine entry latency0.70.91.51.01.21.00.5
Pavlov. Cond. change in total contacts0.50.50.70.70.90.70.4
Pavlov. Cond. index score0.00.00.10.10.30.10.0
Pavlov. Cond. latency score0.10.10.10.20.40.20.2
Pavlov. Cond. lever contacts0.00.00.0-0.00.1-0.00.0
Pavlov. Cond. magazine entry number0.00.00.10.1-0.10.10.2
Pavlov. Cond. intertrial magazine entries0.00.00.00.00.10.10.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.00.2-0.0-0.2
Pavlov. Cond. response bias0.00.00.0-0.00.2-0.1-0.1
Bone: apparent density1.11.82.41.61.41.50.5
Bone surface0.30.51.40.40.20.4-1.2
Bone volume0.50.81.31.10.91.1-0.2
Bone: connectivity density0.40.60.70.80.80.8-0.6
Bone: cortical apparent density0.30.40.6-0.7-0.4-0.7-0.8
Bone: cortical area0.91.31.7-1.0-1.3-1.0-1.3
Bone: cortical porosity0.20.20.30.60.40.50.2
Bone: cortical porosity0.00.00.10.1-0.10.1-0.3
Bone: cortical thickness5.79.410.4-3.0-3.1-3.0-3.2
Bone: cortical thickness3.23.84.1-2.0-2.0-2.0-1.8
Bone: cortical tissue density0.50.60.8-0.8-0.5-0.8-0.9
Bone: elastic displacement0.60.61.0-1.0-0.7-1.0-0.2
Bone: elastic work2.73.63.7-1.9-1.9-1.9-1.8
Bone: endosteal estimation2.24.75.02.22.02.22.2
Bone: endosteal perimeter3.77.68.22.82.62.92.7
Bone: final force1.11.93.2-1.1-1.4-1.1-1.8
Bone: final moment1.01.62.7-1.0-1.3-1.0-1.7
Bone: marrow area2.34.95.12.22.12.32.3
Bone: maximum diameter0.00.00.0-0.1-0.2-0.1-0.2
Bone: maximum force0.30.51.9-0.2-0.4-0.2-1.4
Bone: maximum moment0.30.51.6-0.2-0.4-0.2-1.3
Bone: minimum diameter2.85.26.12.52.12.52.1
Bone: periosteal estimation0.10.30.40.60.30.60.4
Bone: periosteal perimeter0.20.30.50.70.40.70.3
Bone: post-yield work5.27.18.72.92.92.91.6
Bone: stiffness0.10.20.80.30.10.3-0.9
Bone: tissue strength0.20.20.30.40.50.40.2
Bone: trabecular number0.91.41.91.41.31.40.3
Bone: trabecular spacing0.10.10.2-0.4-0.3-0.40.1
Bone: trabecular thickness1.92.32.61.61.61.61.3
Bone: trabecular tissue density1.01.43.30.90.90.81.8
Breakpoint value in progressive ratio session1.61.83.3-1.2-1.2-1.1-1.8
Distance traveled before self-admin0.10.10.2-0.2-0.2-0.2-0.4
Distance traveled after self-admin0.00.00.10.0-0.0-0.1-0.2
Delta time in closed arm before/after self-admin0.50.40.6-0.7-0.4-0.8-0.7
Delta time in open arm before/after self-admin0.00.00.0-0.1-0.10.0-0.0
Diff in mean of infusions in LGA sessions0.50.50.9-0.8-0.3-0.7-0.9
Extinction: sum of active levers before priming1.21.22.9-0.9-0.7-0.7-1.7
Active lever presses in extinction session 62.92.73.4-1.6-1.5-1.7-1.8
Delta distance traveled before/after self-admin0.00.00.0-0.10.1-0.1-0.0
Delta ambulatory time before/after self-admin0.00.00.1-0.3-0.1-0.2-0.2
Time in closed arm before self-admin0.20.20.40.30.60.30.4
Time in closed arm after self-admin0.10.10.4-0.00.6-0.1-0.0
Time in open arm before self-admin0.00.00.1-0.1-0.3-0.20.2
Time in open arm after self-admin0.10.10.3-0.3-0.5-0.20.0
Sum of active levers in priming session hrs 5-62.22.22.9-1.6-1.0-1.5-1.7
Time to tail flick, vehicle, before self-admin0.00.00.10.10.20.1-0.3
Time to tail flick, vehicle, after self-admin0.40.50.9-0.4-0.6-0.7-0.9
Time to tail flick, test, before self-admin1.01.01.31.00.81.11.0
Time to tail flick, test, after self-admin0.00.00.0-0.10.10.0-0.1
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.2-0.6-0.4-0.5
Delta time to tail flick, test, before/after SA2.92.63.1-1.6-1.4-1.8-1.6
Ambulatory time before self-admin0.00.00.10.10.10.2-0.2
Ambulatory time after self-admin1.11.21.51.21.21.10.8
Total heroin consumption2.83.45.8-1.8-1.3-1.6-2.4
Area under the delay curve0.60.60.80.90.70.80.8
Delay disc. indifference point, 0s delay0.80.91.20.90.80.91.1
Delay disc. indifference point, 16s delay2.32.43.01.71.51.51.5
Delay disc. indifference point, 2s delay0.20.20.40.50.40.50.6
Delay disc. indifference point, 24s delay0.10.10.3-0.3-0.3-0.6-0.1
Delay disc. indifference point, 4s delay0.30.30.40.60.40.50.6
Delay disc. indifference point, 8s delay0.10.10.20.40.20.40.4
Delay discount exponential model param0.40.40.5-0.7-0.5-0.6-0.6
Delay discount hyperbolic model param0.30.30.4-0.6-0.4-0.5-0.6
Fecal boli incidents, locomotor time 10.10.10.30.40.50.2-0.0
Change in fecal boli incidents, locomotor task0.00.00.00.2-0.00.10.1
Time >=10cm from walls, locomotor time 14.24.35.22.32.12.11.7
Bouts of movement, locomotor time 10.50.61.1-0.6-0.6-0.6-1.1
Total resting periods, locomotor time 10.20.20.6-0.2-0.2-0.3-0.7
Rest time, locomotor task time 10.40.41.10.50.40.41.0
Distance moved, locomotor task time 10.20.20.30.60.30.60.1
Vertical activity count, locomotor time 10.50.60.70.80.70.70.9
Time >=10cm from walls, locomotor time 20.10.10.20.40.40.30.3
Bouts of movement, locomotor time 20.20.20.5-0.4-0.3-0.3-0.7
Total resting periods, locomotor time 20.00.00.1-0.1-0.00.0-0.4
Rest time, locomotor task time 21.41.62.61.31.01.01.6
Distance moved, locomotor task time 20.81.01.4-0.8-1.0-0.8-1.2
Vertical activity count, locomotor time 21.31.41.7-1.2-1.3-1.3-0.9
Weight adjusted by age2.02.23.4-1.3-1.4-1.3-1.8
Seeking ratio, delayed vs. immediate footshock0.30.40.50.70.60.70.5
Locomotion in novel chamber3.23.95.91.81.81.82.4
Locomotion in novel chamber post-restriction1.61.93.21.21.31.21.8
Progressive ratio0.30.40.60.80.60.7-0.4
Food seeking constrained by brief footshock0.50.60.6-0.7-0.8-0.8-0.8
Seeking ratio, punishment vs. effort0.40.40.7-0.8-0.7-0.70.3
Run reversals in cocaine runway, females0.00.00.10.20.00.1-0.2
Run reversals in cocaine runway, males1.51.51.9-1.4-1.3-1.4-0.7
Latency to leave start box in cocaine runway0.60.71.01.00.90.90.6
Latency to leave start box in cocaine runway, F0.20.20.40.60.50.50.3
Latency to leave start box in cocaine runway, M0.00.00.00.20.10.20.1
Cd content in liver0.40.50.90.50.70.51.0
Co content in liver0.40.40.8-0.7-0.9-0.60.3
Cu content in liver0.10.10.20.0-0.50.0-0.4
Fe content in liver0.10.20.2-0.4-0.4-0.4-0.5
K content in liver0.10.10.5-0.0-0.30.1-0.7
Mg content in liver1.61.62.51.51.21.60.8
Mn content in liver0.70.82.1-0.8-0.2-0.6-1.5
Na content in liver1.11.21.3-1.1-1.0-1.1-1.1
Rb content in liver2.63.33.81.91.51.91.8
Se content in liver0.81.01.51.11.01.20.5
Sr content in liver3.53.23.8-1.7-1.8-1.7-1.9
Zn content in liver0.50.51.0-0.5-0.8-0.5-1.0