Hub : Genes

Suox

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000005987 0.1 0.06 1.2e-07 0.04 0.07 0.06 0.06 2.4e-05 8.4e-08 1.0e-07 2.3e-07
2 NAcc alternative TSS ENSRNOT00000008018 0.03 0.03 6.2e-03 0.04 0.03 0.03 0.03 1.2e-03 5.3e-03 2.7e-03 3.6e-03
3 NAcc alternative TSS ENSRNOT00000108072 0.04 0.03 4.1e-03 0.04 0.03 0.03 0.03 6.1e-04 2.6e-03 1.6e-03 2.1e-03
4 OFC gene expression ENSRNOG00000005987 0.19 0.13 5.0e-03 0.08 0.07 0.09 0.08 6.3e-03 7.7e-03 3.4e-03 7.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail5.417.625.22.35.0-5.0-3.9
BMI without tail1.12.34.10.32.0-2.0-0.9
Body weight0.94.05.71.02.3-2.4-1.9
Epididymis fat weight0.10.20.4-0.6-0.20.20.5
Glucose1.32.03.00.71.7-1.7-1.3
Heart weight0.10.10.3-0.50.2-0.20.5
Left kidney weight0.51.33.01.7-0.30.3-1.4
Right kidney weight0.20.61.00.4-1.01.00.2
Tail length3.410.312.3-2.5-3.43.33.5
Length with tail1.14.16.6-0.9-2.62.51.6
Length without tail0.30.71.61.2-0.10.0-1.2
Liver weight, left1.11.83.50.11.9-1.8-0.7
Liver weight, right0.81.31.90.71.4-1.3-1.0
Parametrial fat weight0.10.20.4-0.5-0.10.10.6
Retroperitoneal fat weight1.75.69.60.73.1-3.1-1.7
Intraocular pressure0.81.22.7-1.7-0.30.31.4
Extensor digitorum longus weight3.915.627.50.75.2-5.2-2.7
Soleus weight4.613.419.11.94.4-4.3-3.5
Tibialis anterior weight1.03.44.81.02.2-2.2-1.8
Tibia length0.72.02.3-1.1-1.51.51.5
Number of licking bursts2.52.95.4-0.02.3-2.3-0.9
Food consumed during 24 hour testing period0.50.60.90.41.0-1.0-0.6
Times rat made contact with spout1.11.32.5-0.21.6-1.6-0.3
Mean time between licks in bursts0.81.12.0-1.1-0.80.81.4
Mean num. licks in bursts0.50.61.0-0.1-1.01.00.6
Std. dev. time between licks in bursts0.70.81.20.8-1.11.1-0.1
Water consumed over 24 hours1.21.42.41.60.7-0.7-1.5
Indifference point 0 sec2.74.45.61.52.4-2.4-2.0
Indifference point AUC0.40.40.6-0.5-0.80.80.6
Indifference point function ln k0.10.10.20.10.5-0.50.0
Indifference point function log k0.10.10.20.10.5-0.50.0
Delay discounting total patch changes 0 sec2.44.05.51.32.3-2.3-1.8
Delay discounting total patch changes 12 sec1.41.83.4-0.01.8-1.8-0.7
Delay discounting total patch changes 18 sec0.00.00.10.10.3-0.3-0.2
Delay discounting total patch changes 24 sec0.60.71.10.80.7-0.7-1.1
Delay discounting total patch changes 6 sec1.42.23.10.91.8-1.8-1.3
Delay discounting time to switch 0 sec0.50.71.61.10.2-0.2-1.2
Delay discounting water rate 0 sec0.50.81.3-0.71.2-1.20.3
Delay discounting water rate 12 sec0.71.12.0-0.71.4-1.40.3
Delay discounting water rate 18 sec1.92.54.9-2.20.9-0.91.9
Delay discounting water rate 24 sec2.73.74.7-2.02.2-2.21.1
Delay discounting water rate 6 sec1.42.14.5-2.0-0.00.02.1
Locomotor activity1.92.95.5-0.0-2.32.30.9
Locomotor testing distance0.71.12.0-0.0-1.41.40.6
Locomotor testing rearing0.10.10.2-0.40.2-0.20.3
Light reinforcement 12.64.76.7-0.9-2.62.62.1
Light reinforcement 20.70.91.2-0.5-1.11.11.0
Reaction time number correct0.71.01.9-0.51.4-1.4-0.2
Reaction time mean minus median1.11.42.4-0.4-1.61.60.8
Reaction time mean minus median AUC1.92.44.30.9-2.12.1-0.2
Reaction time num false alarms0.50.61.20.11.1-1.1-0.4
Reaction time num false alarms AUC0.60.81.6-0.21.3-1.3-0.2
Reaction time trials correct on left0.71.01.9-0.51.4-1.4-0.2
Reaction time trials on left0.60.91.7-0.41.3-1.3-0.3
Reaction time mean1.11.52.90.5-1.71.7-0.0
Reaction time mean AUC0.70.91.50.7-1.21.2-0.3
Median of all reaction times0.60.91.50.6-1.21.2-0.3
Reaction time omissions0.10.10.20.5-0.20.2-0.3
Reaction time false alarm rate0.10.20.20.30.4-0.4-0.4
Reaction time premature initiation rate1.41.93.5-1.7-0.80.81.9
Reaction time premature initiations1.31.94.2-2.0-0.10.11.8
Std. dev. reaction times0.81.12.10.3-1.41.40.2
Reaction time trials completed0.60.91.7-0.41.3-1.3-0.3
Reaction time trials AUC0.81.22.1-0.61.5-1.5-0.1
Social response proportion0.60.71.40.2-1.21.20.0
Social responses5.97.713.7-0.5-3.73.71.7
Social time0.91.21.90.21.4-1.4-0.9
Conditioned locomotion0.91.11.9-0.91.4-1.40.0
Cocaine response after cond. corrected1.72.03.7-0.61.9-1.9-0.3
Cocaine response after cond. not corrected2.12.34.3-0.82.1-2.1-0.1
Cocaine response before conditioning0.30.30.5-0.1-0.70.70.5
Saline control response0.20.30.6-0.00.8-0.8-0.3
Condit. Reinf. active minus inactive responses2.02.54.8-1.8-1.11.12.2
Condit. Reinf. active-inactive response ratio1.71.83.9-2.00.1-0.11.8
Condit. Reinf. active responses1.11.62.4-0.9-1.31.31.6
Condit. Reinf. inactive responses0.40.51.00.4-1.01.00.1
Condit. Reinf. lever presses2.43.45.1-1.7-1.61.62.3
Condit. Reinf. lever reinforcers received1.01.42.5-1.1-1.01.01.6
Pavlov. Cond. lever latency1.31.72.70.61.6-1.6-1.1
Pavlov. Cond. magazine entry latency1.82.03.2-0.6-1.81.81.2
Pavlov. Cond. change in total contacts0.60.81.1-0.6-0.90.91.0
Pavlov. Cond. index score1.62.12.7-0.8-1.71.71.4
Pavlov. Cond. latency score1.62.03.2-0.6-1.81.81.2
Pavlov. Cond. lever contacts1.11.61.8-1.0-1.31.31.4
Pavlov. Cond. magazine entry number1.61.93.00.51.7-1.7-1.2
Pavlov. Cond. intertrial magazine entries0.70.91.8-0.21.3-1.3-0.3
Pavlov. Cond. lever-magazine prob. diff.1.62.13.0-0.7-1.71.71.4
Pavlov. Cond. response bias1.82.43.0-1.2-1.61.61.7
Conditioned reinforcement - actives0.10.10.30.6-0.30.30.1
Conditioned reinforcement - inactives1.41.62.7-0.71.7-1.70.6
Conditioned locomotion1.92.33.4-0.6-1.61.61.9
Intermittent access intake day 1-15 change0.70.72.0-0.8-0.20.21.4
Intermittent access intake escalation1.71.73.7-1.60.4-0.41.9
Intermittent access intake escalation 21.71.74.2-1.6-0.10.12.0
Intermitt. access day 1 inactive lever presses1.31.42.9-1.50.5-0.51.7
Intermitt. access day 15 inactive lever presses1.41.53.6-1.5-0.40.41.9
Intermitt. access escalation Index0.60.61.31.1-0.60.6-0.5
Intermittent access day 1 total infusions0.30.40.60.70.5-0.5-0.8
Intermittent access day 15 total infusions0.30.30.4-0.30.6-0.60.5
Intermittent access terminal intake (last 3 days)0.10.10.30.50.3-0.3-0.1
Intermittent access total infusions0.20.30.50.20.7-0.7-0.2
Intermittent access day 1 locomotion0.00.00.0-0.10.1-0.1-0.0
Intermittent access day 15 total locomotion0.70.72.0-0.8-0.30.31.4
Intermittent access total locomotion0.20.20.3-0.2-0.50.50.5
Intermittent access standard deviation0.50.61.6-0.80.0-0.01.3
Cocaine induced anxiety1.41.63.10.6-1.81.8-0.0
Post-drug Anxiety1.51.72.41.6-1.21.2-1.1
Baseline Anxiety0.10.10.2-0.40.2-0.20.3
Lifetime Intake0.60.70.90.80.9-0.9-0.7
Incentive Sensitization - Responses0.10.10.3-0.1-0.30.30.5
Incentive Sensitization - Breakpoint0.10.10.20.0-0.40.40.4
Progressive ratio test 1 active lever presses0.90.91.70.41.3-1.3-0.6
Progressive ratio test 1 breakpoint1.01.01.60.51.3-1.3-0.7
Progressive ratio test 1 inactive lever presses0.10.10.50.00.1-0.10.7
Progressive ratio test 2 active lever presses0.30.30.60.40.7-0.7-0.2
Progressive ratio test 2 breakpoint0.10.20.50.70.2-0.2-0.3
Progressive ratio test 2 inactive lever presses0.20.20.40.60.4-0.4-0.2
Total sessions with >9 infusions0.70.72.41.5-0.00.0-0.8
Short access day 1 total inactive lever presses0.00.00.10.10.1-0.10.3
Short access day 10 total inactive lever presses0.70.81.6-1.10.5-0.51.3
Short access day 1 total infusions1.11.23.21.80.4-0.4-1.1
Short access day 10 total infusions0.50.50.80.60.9-0.9-0.5
Short access total infusions1.41.62.91.70.9-0.9-1.4
Short access day 1 locomotion0.10.10.30.6-0.40.4-0.0
Short access day 10 total locomotion1.92.15.1-1.5-0.80.82.2
Short access total locomotion0.10.20.30.0-0.40.40.5
Compulsive drug intake0.20.20.40.40.3-0.3-0.6
One hour access (0.3 mA shock)0.20.30.40.30.6-0.6-0.3
One hour access (shock baseline)0.30.40.4-0.60.6-0.60.6
Number of responses in last shaping day0.90.91.9-0.5-0.80.81.4
Context. condit. distance diff. score0.10.20.20.10.5-0.5-0.3
Locomotion velocity, session 11.01.12.31.5-0.30.3-1.4
Locomotion distance, session 11.01.32.31.5-1.01.0-1.0
Locomotion velocity, session 21.71.93.01.3-1.71.7-0.4
Locomotion distance, session 22.43.56.51.0-2.62.6-0.1
Locomotion velocity, session 33.54.15.7-1.2-2.42.41.9
Locomotion distance, session 30.10.10.1-0.4-0.20.20.3
Stereotopy head waving bouts, day 34.04.87.8-0.7-2.82.81.8
Stereotopy head waving duration, day 32.63.24.7-0.6-2.22.21.7
Locomotion velocity, session 70.10.10.20.4-0.40.4-0.2
Locomotion distance, session 70.20.30.5-0.70.5-0.50.4
Stereotopy head waving bouts, day 71.01.21.90.8-1.41.4-0.3
Stereotopy head waving duration, day 71.21.42.01.1-1.41.4-0.6
Locomotion velocity, session 81.82.13.21.3-1.81.8-0.7
Locomotion distance, session 80.30.51.00.3-1.01.0-0.1
Degree of sensitization distance0.40.40.50.40.7-0.7-0.6
Degree of sensitization stereotypy0.60.71.41.1-0.20.2-1.2
Condit. Reinf. active minus inactive responses1.41.62.4-0.5-1.61.61.1
Condit. Reinf. active-inactive response ratio0.40.41.0-0.8-0.20.21.0
Condit. Reinf. active responses2.22.65.00.1-2.22.20.8
Condit. Reinf. inactive responses1.51.83.40.7-1.81.8-0.0
Incentive salience index mean1.11.32.60.3-1.61.60.3
Condit. Reinf. lever presses1.52.02.91.7-1.31.3-1.3
Time in familiar zone, hab. session 13.73.54.2-1.6-1.91.92.0
Time in novel zone, hab. session 13.53.45.42.11.4-1.4-2.3
Total zone transitions, hab. session 10.91.31.71.1-1.31.3-0.6
Total locomotion distance, hab. session 12.23.25.11.5-2.32.3-0.5
Locomotion velocity, hab. session 11.92.74.81.0-2.22.2-0.1
Time in familiar zone, hab. session 24.14.36.7-2.1-1.81.82.6
Time in novel zone, hab. session 24.84.87.62.31.8-1.8-2.7
Total zone transitions, hab. session 21.62.14.52.1-0.00.0-1.9
Total locomotion distance, hab. session 20.81.01.31.1-1.11.1-0.7
Locomotion velocity, hab. session 21.11.51.81.4-1.31.3-0.9
Novel to familiar place preference ratio3.13.35.92.21.1-1.1-2.4
Novelty place preference2.32.34.22.00.8-0.8-2.1
Time in novel zone, NPP test2.62.74.62.01.1-1.1-2.1
Total zone transitions, NPP test0.60.92.01.30.1-0.1-1.4
Total locomotion distance, NPP test0.71.02.01.4-0.50.5-1.3
Locomotion velocity, NPP test0.60.91.41.2-0.70.7-1.0
Pavlov. Cond. lever latency0.70.91.3-1.20.8-0.80.9
Pavlov. Cond. magazine entry latency1.21.61.9-0.9-1.41.41.3
Pavlov. Cond. change in total contacts0.10.10.20.40.2-0.2-0.5
Pavlov. Cond. index score0.50.71.20.5-1.11.1-0.1
Pavlov. Cond. latency score0.81.01.60.8-1.31.3-0.4
Pavlov. Cond. lever contacts1.11.32.21.5-0.80.8-1.3
Pavlov. Cond. magazine entry number0.40.50.90.30.9-0.9-0.5
Pavlov. Cond. intertrial magazine entries0.40.51.0-1.00.1-0.10.9
Pavlov. Cond. lever-magazine prob. diff.0.60.71.40.4-1.21.20.0
Pavlov. Cond. response bias0.60.71.2-0.3-1.11.10.4
Bone: apparent density1.62.76.32.5-0.80.8-1.8
Bone surface3.05.211.43.4-1.61.6-2.1
Bone volume3.25.412.33.5-1.41.4-2.3
Bone: connectivity density0.91.43.31.8-0.60.6-1.2
Bone: cortical apparent density0.91.21.80.51.3-1.4-0.9
Bone: cortical area1.32.04.22.10.5-0.5-1.8
Bone: cortical porosity0.10.10.30.6-0.30.3-0.2
Bone: cortical porosity0.40.51.31.10.0-0.0-0.8
Bone: cortical thickness1.11.92.61.51.2-1.2-1.6
Bone: cortical thickness0.60.71.4-0.01.2-1.2-0.4
Bone: cortical tissue density0.70.81.40.41.1-1.2-0.7
Bone: elastic displacement0.00.00.00.2-0.00.0-0.1
Bone: elastic work0.71.01.71.20.6-0.6-1.3
Bone: endosteal estimation0.61.21.91.40.8-0.8-1.3
Bone: endosteal perimeter0.30.60.91.0-0.80.9-0.3
Bone: final force2.64.26.82.31.5-1.5-2.6
Bone: final moment2.54.06.52.31.5-1.5-2.6
Bone: marrow area0.51.11.71.30.8-0.7-1.2
Bone: maximum diameter0.71.21.71.3-1.21.2-0.5
Bone: maximum force2.54.46.62.21.8-1.7-2.6
Bone: maximum moment2.54.36.52.21.7-1.7-2.5
Bone: minimum diameter0.40.82.01.40.2-0.1-1.1
Bone: periosteal estimation1.32.65.32.30.7-0.6-2.1
Bone: periosteal perimeter0.61.02.61.6-0.40.4-1.1
Bone: post-yield work0.30.40.60.40.8-0.8-0.5
Bone: stiffness3.55.57.02.12.3-2.3-2.6
Bone: tissue strength3.33.23.61.41.9-1.9-1.9
Bone: trabecular number1.11.72.41.3-1.51.5-0.6
Bone: trabecular spacing2.22.95.3-2.31.3-1.31.6
Bone: trabecular thickness4.35.211.93.5-1.11.1-2.6
Bone: trabecular tissue density3.85.39.60.43.1-3.1-1.4
Breakpoint value in progressive ratio session1.82.03.2-1.3-1.31.31.8
Distance traveled before self-admin0.60.71.1-0.2-1.11.10.6
Distance traveled after self-admin0.10.10.30.1-0.50.50.2
Delta time in closed arm before/after self-admin2.62.53.1-1.81.7-1.71.2
Delta time in open arm before/after self-admin1.31.22.51.00.8-0.8-1.6
Diff in mean of infusions in LGA sessions1.61.82.4-0.9-1.41.41.6
Extinction: sum of active levers before priming2.82.84.4-2.0-1.21.22.1
Active lever presses in extinction session 60.80.81.5-0.1-1.21.20.4
Delta distance traveled before/after self-admin0.00.00.10.30.1-0.1-0.3
Delta ambulatory time before/after self-admin0.20.30.60.8-0.00.0-0.7
Time in closed arm before self-admin0.91.02.11.4-0.30.3-1.4
Time in closed arm after self-admin0.20.20.30.20.6-0.6-0.1
Time in open arm before self-admin0.70.71.9-1.0-0.10.11.4
Time in open arm after self-admin0.70.81.40.11.2-1.2-0.6
Sum of active levers in priming session hrs 5-60.30.30.4-0.4-0.50.50.6
Time to tail flick, vehicle, before self-admin1.81.83.21.0-1.81.80.2
Time to tail flick, vehicle, after self-admin0.60.61.4-1.2-0.10.11.1
Time to tail flick, test, before self-admin1.11.11.90.8-1.41.4-0.2
Time to tail flick, test, after self-admin0.50.61.01.0-0.70.7-0.6
Delta time to tail flick, vehicle, before/after SA1.41.42.1-1.21.4-1.4-0.0
Delta time to tail flick, test, before/after SA0.30.30.7-0.80.0-0.00.6
Ambulatory time before self-admin0.20.20.3-0.2-0.60.60.5
Ambulatory time after self-admin0.00.00.00.2-0.20.20.0
Total heroin consumption1.72.03.5-0.3-1.91.90.9
Area under the delay curve0.20.30.70.6-0.10.1-0.8
Delay disc. indifference point, 0s delay2.93.26.92.40.4-0.4-2.6
Delay disc. indifference point, 16s delay0.20.20.30.0-0.60.60.0
Delay disc. indifference point, 2s delay0.60.71.61.10.1-0.1-1.3
Delay disc. indifference point, 24s delay0.40.30.90.50.3-0.3-0.9
Delay disc. indifference point, 4s delay0.70.71.00.8-1.01.0-0.5
Delay disc. indifference point, 8s delay0.20.20.2-0.40.5-0.5-0.0
Delay discount exponential model param0.20.20.5-0.50.2-0.20.7
Delay discount hyperbolic model param0.30.30.8-0.60.0-0.00.9
Fecal boli incidents, locomotor time 10.70.71.2-0.61.1-1.1-0.0
Change in fecal boli incidents, locomotor task1.00.91.31.0-1.11.1-0.5
Time >=10cm from walls, locomotor time 11.01.01.91.40.3-0.3-1.4
Bouts of movement, locomotor time 10.40.40.6-0.6-0.60.60.8
Total resting periods, locomotor time 10.80.81.1-0.6-1.11.10.9
Rest time, locomotor task time 10.40.40.80.1-0.90.90.2
Distance moved, locomotor task time 10.91.02.01.40.4-0.4-1.3
Vertical activity count, locomotor time 10.80.91.70.21.3-1.3-0.4
Time >=10cm from walls, locomotor time 20.90.91.8-0.01.3-1.3-0.4
Bouts of movement, locomotor time 20.50.60.70.8-0.90.9-0.4
Total resting periods, locomotor time 20.60.71.01.0-0.90.9-0.5
Rest time, locomotor task time 20.40.40.70.8-0.50.5-0.6
Distance moved, locomotor task time 20.30.40.7-0.80.5-0.50.6
Vertical activity count, locomotor time 21.41.52.8-0.71.7-1.70.0
Weight adjusted by age0.20.30.5-0.70.3-0.30.6
Seeking ratio, delayed vs. immediate footshock1.01.11.90.2-1.41.40.7
Locomotion in novel chamber0.10.20.30.10.6-0.6-0.1
Locomotion in novel chamber post-restriction2.52.94.2-1.0-2.12.11.6
Progressive ratio0.91.02.00.11.4-1.4-0.5
Food seeking constrained by brief footshock1.21.42.2-0.7-1.51.50.8
Seeking ratio, punishment vs. effort1.72.03.4-0.7-1.81.81.0
Run reversals in cocaine runway, females1.31.32.40.0-1.61.60.5
Run reversals in cocaine runway, males1.81.83.2-0.0-1.81.80.8
Latency to leave start box in cocaine runway1.31.42.91.7-0.40.4-1.5
Latency to leave start box in cocaine runway, F2.62.85.72.4-0.60.6-2.2
Latency to leave start box in cocaine runway, M0.50.50.8-0.90.6-0.60.8
Cd content in liver0.20.30.60.40.3-0.4-0.8
Co content in liver1.11.32.1-1.2-0.90.91.4
Cu content in liver1.31.52.91.70.7-0.7-1.5
Fe content in liver0.40.50.9-0.31.0-0.9-0.1
K content in liver0.60.61.00.6-1.01.0-0.0
Mg content in liver0.80.91.11.0-1.01.1-0.5
Mn content in liver2.32.64.52.1-1.51.5-1.2
Na content in liver0.30.30.70.8-0.10.1-0.8
Rb content in liver0.91.12.41.60.6-0.5-1.2
Se content in liver0.00.00.10.1-0.20.2-0.1
Sr content in liver1.21.12.2-1.50.2-0.21.4
Zn content in liver2.73.05.7-2.4-0.70.72.3