Hub : Genes

Dok2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000013922	0.06	0.04	3.1e-05	0.03	0.03	0.03	0.03	1.0e-04	9.7e-05	1.7e-04	1.4e-04
2	Adipose	mRNA stability	ENSRNOG00000013922	0.04	0.03	5.7e-04	0.01	0.01	0.01	0.01	4.1e-02	1.7e-02	2.2e-02	3.8e-02
3	OFC	gene expression	ENSRNOG00000013922	0.15	0.11	8.7e-03	0.08	0.06	-0.01	0.06	7.1e-03	1.7e-02	5.7e-01	1.3e-02
4	PL	alternative TSS	ENSRNOT00000103496	0.04	0.03	7.8e-03	0.01	0.02	0.01	0.01	4.7e-02	1.6e-02	6.1e-02	3.5e-02
5	PL	alternative TSS	ENSRNOT00000119823	0.04	0.03	9.7e-03	0.01	0.01	0.01	0.01	6.2e-02	2.2e-02	9.3e-02	5.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	0.4	1.4	2.5	-0.5	0.0	1.2	-1.6	1.6
BMI without tail	0.8	1.6	2.6	-1.6	-1.6	-1.1	0.9	-0.9
Body weight	0.4	1.7	2.0	1.2	1.3	1.4	-1.3	1.3
Epididymis fat weight	1.7	4.1	5.1	-1.5	-1.9	-2.3	2.2	-2.2
Glucose	0.3	0.5	1.4	-1.2	-1.0	-0.1	-0.2	0.2
Heart weight	0.1	0.1	0.3	0.5	0.4	-0.1	0.3	-0.3
Left kidney weight	0.4	1.1	1.8	1.3	1.3	0.9	-0.7	0.7
Right kidney weight	0.3	0.8	1.3	1.2	0.8	-0.5	0.9	-0.9
Tail length	0.7	2.0	3.8	0.2	-0.4	-1.5	1.9	-1.9
Length with tail	0.3	1.2	3.3	1.8	1.6	0.5	-0.1	0.1
Length without tail	3.4	7.5	8.4	2.6	2.9	2.8	-2.7	2.7
Liver weight, left	1.8	2.9	3.7	1.2	1.5	1.9	-1.8	1.8
Liver weight, right	0.5	0.9	1.4	0.4	0.6	1.1	-1.2	1.2
Parametrial fat weight	2.7	5.3	6.8	-1.8	-2.2	-2.6	2.5	-2.4
Retroperitoneal fat weight	0.3	0.8	1.8	-1.3	-1.2	-0.8	0.4	-0.4
Intraocular pressure	0.5	0.7	1.0	-0.4	-0.6	-0.9	1.0	-1.0
Extensor digitorum longus weight	9.7	39.0	50.6	4.1	5.3	7.1	-7.1	7.1
Soleus weight	0.7	2.2	3.5	0.5	0.9	1.7	-1.9	1.9
Tibialis anterior weight	6.5	22.6	28.3	3.6	4.4	5.3	-5.1	5.1
Tibia length	1.5	4.2	7.3	1.6	0.6	-1.9	2.7	-2.7
Number of licking bursts	0.0	0.0	0.1	-0.3	-0.2	0.1	-0.2	0.2
Food consumed during 24 hour testing period	0.4	0.5	0.8	0.7	0.4	-0.5	0.9	-0.9
Times rat made contact with spout	0.4	0.5	0.6	-0.7	-0.8	-0.7	0.6	-0.6
Mean time between licks in bursts	1.6	2.2	3.6	-0.5	-0.9	-1.7	1.9	-1.9
Mean num. licks in bursts	0.3	0.4	0.5	-0.4	-0.5	-0.7	0.7	-0.7
Std. dev. time between licks in bursts	1.7	2.0	3.5	1.0	0.4	-1.3	1.9	-1.9
Water consumed over 24 hours	1.2	1.4	1.8	1.2	1.3	1.3	-1.1	1.1
Indifference point 0 sec	2.4	3.8	6.6	1.4	0.5	-1.9	2.6	-2.6
Indifference point AUC	0.5	0.6	1.1	-0.4	-0.1	0.9	-1.0	1.0
Indifference point function ln k	0.3	0.5	1.2	1.1	0.8	-0.2	0.5	-0.5
Indifference point function log k	0.3	0.5	1.2	1.1	0.8	-0.2	0.5	-0.5
Delay discounting total patch changes 0 sec	2.1	3.4	5.8	1.5	0.6	-1.7	2.4	-2.4
Delay discounting total patch changes 12 sec	0.8	1.0	1.9	0.7	0.2	-1.0	1.4	-1.4
Delay discounting total patch changes 18 sec	1.5	2.0	3.2	-0.5	-0.9	-1.6	1.8	-1.8
Delay discounting total patch changes 24 sec	0.7	0.8	2.3	1.5	1.2	-0.0	0.5	-0.5
Delay discounting total patch changes 6 sec	0.2	0.3	0.6	-0.0	-0.2	-0.6	0.8	-0.8
Delay discounting time to switch 0 sec	0.6	1.0	1.1	-0.8	-1.0	-1.1	1.0	-1.0
Delay discounting water rate 0 sec	0.5	0.8	1.4	1.2	1.2	0.8	-0.5	0.5
Delay discounting water rate 12 sec	0.7	1.0	1.6	1.2	1.2	1.0	-0.7	0.7
Delay discounting water rate 18 sec	2.4	3.2	4.6	0.9	1.4	2.0	-2.2	2.2
Delay discounting water rate 24 sec	0.2	0.3	0.4	-0.6	-0.4	0.4	-0.6	0.6
Delay discounting water rate 6 sec	2.2	3.2	4.7	2.1	2.2	1.8	-1.4	1.4
Locomotor activity	4.0	6.3	15.7	4.0	3.6	1.6	-0.6	0.6
Locomotor testing distance	2.0	3.3	9.2	3.0	2.4	0.0	0.9	-0.9
Locomotor testing rearing	2.8	4.4	10.7	3.3	2.4	-0.5	1.6	-1.6
Light reinforcement 1	3.1	5.7	6.7	-2.4	-2.6	-2.6	2.2	-2.2
Light reinforcement 2	2.6	3.5	7.7	-2.8	-2.6	-1.4	0.8	-0.7
Reaction time number correct	0.5	0.7	1.3	-0.1	0.2	1.0	-1.1	1.2
Reaction time mean minus median	0.5	0.6	1.4	1.2	1.1	0.6	-0.2	0.2
Reaction time mean minus median AUC	0.2	0.3	0.6	0.8	0.7	0.5	-0.2	0.2
Reaction time num false alarms	0.1	0.1	0.3	0.5	0.5	0.2	-0.2	0.2
Reaction time num false alarms AUC	0.0	0.1	0.2	0.4	0.3	-0.0	-0.0	-0.0
Reaction time trials correct on left	0.5	0.7	1.3	-0.1	0.2	1.0	-1.1	1.2
Reaction time trials on left	0.4	0.6	1.1	-0.2	0.1	0.8	-1.0	1.0
Reaction time mean	0.2	0.3	0.7	0.8	0.8	0.5	-0.3	0.3
Reaction time mean AUC	0.5	0.6	1.2	1.1	1.1	0.7	-0.4	0.4
Median of all reaction times	0.1	0.1	0.2	0.4	0.4	0.2	-0.1	0.1
Reaction time omissions	1.8	2.4	3.2	-1.0	-1.3	-1.7	1.8	-1.8
Reaction time false alarm rate	0.1	0.1	0.2	0.1	-0.0	-0.4	0.5	-0.5
Reaction time premature initiation rate	1.1	1.4	2.7	-0.3	0.2	1.2	-1.6	1.7
Reaction time premature initiations	1.7	2.4	4.6	-0.4	0.2	1.6	-2.1	2.1
Std. dev. reaction times	0.3	0.5	1.0	1.0	0.9	0.6	-0.2	0.2
Reaction time trials completed	0.4	0.6	1.1	-0.2	0.1	0.8	-1.0	1.0
Reaction time trials AUC	0.4	0.5	1.0	-0.2	0.1	0.8	-1.0	1.0
Social response proportion	1.3	1.4	3.5	-1.9	-1.4	0.2	-0.8	0.8
Social responses	1.1	1.4	1.9	-1.3	-1.4	-1.2	1.0	-1.0
Social time	0.4	0.6	0.9	0.6	0.2	-0.8	1.0	-1.0
Conditioned locomotion	0.2	0.2	0.6	-0.8	-0.7	-0.2	-0.0	0.0
Cocaine response after cond. corrected	0.8	0.9	1.7	-1.3	-0.8	0.5	-1.0	1.0
Cocaine response after cond. not corrected	0.4	0.4	0.7	-0.8	-0.5	0.4	-0.7	0.7
Cocaine response before conditioning	0.6	0.8	1.5	1.2	0.8	-0.4	0.9	-0.9
Saline control response	0.3	0.3	0.6	0.5	0.3	-0.5	0.7	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.4	-0.5	-0.6	0.6	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	-0.3	-0.1	0.4	-0.5	0.5
Condit. Reinf. active responses	0.7	0.9	1.4	-0.4	-0.7	-1.1	1.2	-1.2
Condit. Reinf. inactive responses	1.7	2.1	3.4	-0.4	-0.8	-1.7	1.8	-1.8
Condit. Reinf. lever presses	0.4	0.6	1.3	1.2	0.8	-0.3	0.7	-0.7
Condit. Reinf. lever reinforcers received	0.4	0.6	1.0	-0.2	-0.5	-0.9	1.0	-1.0
Pavlov. Cond. lever latency	0.9	1.3	3.3	-1.8	-1.6	-0.7	0.3	-0.2
Pavlov. Cond. magazine entry latency	0.4	0.4	0.9	1.0	0.7	-0.3	0.6	-0.6
Pavlov. Cond. change in total contacts	1.8	2.5	3.9	1.9	2.0	1.5	-1.1	1.1
Pavlov. Cond. index score	1.2	1.6	3.9	2.0	1.8	0.8	-0.4	0.3
Pavlov. Cond. latency score	1.1	1.4	3.8	1.9	1.7	0.6	-0.2	0.1
Pavlov. Cond. lever contacts	1.3	1.8	4.6	2.2	1.9	0.7	-0.2	0.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.7	-0.5	0.2	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	4.7	6.0	8.0	-1.5	-2.0	-2.8	2.8	-2.8
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	3.5	1.9	1.7	0.9	-0.5	0.5
Pavlov. Cond. response bias	1.4	1.9	5.0	2.2	2.0	0.8	-0.2	0.2
Conditioned reinforcement - actives	2.8	2.8	3.9	-1.9	-2.0	-1.7	1.3	-1.3
Conditioned reinforcement - inactives	2.2	2.5	3.9	-0.6	-1.0	-1.8	2.0	-2.0
Conditioned locomotion	0.9	1.1	1.2	-0.9	-1.0	-1.1	1.0	-1.0
Intermittent access intake day 1-15 change	1.5	1.5	2.1	-0.7	-1.0	-1.4	1.4	-1.4
Intermittent access intake escalation	1.0	1.0	1.3	-0.7	-0.9	-1.1	1.1	-1.1
Intermittent access intake escalation 2	0.3	0.3	0.4	-0.4	-0.5	-0.6	0.6	-0.6
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.2
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.4	0.6	0.5	-0.1	0.3	-0.3
Intermitt. access escalation Index	0.4	0.3	0.6	0.0	0.2	0.6	-0.7	0.7
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.3	-0.3	-0.2	0.2	-0.2
Intermittent access day 15 total infusions	0.8	0.9	1.0	-0.8	-1.0	-1.0	1.0	-1.0
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.7	-0.8	-0.8	-0.4	0.3	-0.3
Intermittent access total infusions	0.5	0.6	1.0	-1.0	-1.0	-0.7	0.5	-0.5
Intermittent access day 1 locomotion	0.3	0.3	0.5	0.1	-0.1	-0.6	0.7	-0.7
Intermittent access day 15 total locomotion	1.3	1.4	1.6	-1.1	-1.2	-1.3	1.2	-1.2
Intermittent access total locomotion	0.3	0.4	0.5	-0.3	-0.5	-0.7	0.7	-0.7
Intermittent access standard deviation	0.9	0.9	1.5	-0.3	-0.6	-1.1	1.2	-1.2
Cocaine induced anxiety	1.3	1.5	4.4	2.1	1.8	0.4	0.2	-0.2
Post-drug Anxiety	0.6	0.6	1.1	0.6	0.2	-0.7	1.0	-1.0
Baseline Anxiety	0.9	0.9	1.3	-1.1	-1.2	-0.9	0.8	-0.8
Lifetime Intake	0.5	0.6	0.9	-0.9	-0.9	-0.7	0.6	-0.6
Incentive Sensitization - Responses	0.9	0.9	1.0	-0.9	-1.0	-1.0	0.9	-0.9
Incentive Sensitization - Breakpoint	1.1	1.1	1.4	-0.9	-1.0	-1.2	1.1	-1.1
Progressive ratio test 1 active lever presses	0.8	0.8	1.4	-1.2	-0.8	0.5	-0.9	0.9
Progressive ratio test 1 breakpoint	0.9	0.9	2.1	-1.5	-1.0	0.3	-0.8	0.8
Progressive ratio test 1 inactive lever presses	1.5	1.6	1.9	-1.3	-1.4	-1.3	1.2	-1.2
Progressive ratio test 2 active lever presses	1.1	1.2	3.2	-1.8	-1.5	-0.5	-0.0	0.0
Progressive ratio test 2 breakpoint	0.7	0.8	1.9	-1.4	-1.2	-0.5	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.4	-0.5	-0.6	-0.7	0.6	-0.6
Total sessions with >9 infusions	0.2	0.3	0.7	-0.9	-0.7	-0.1	-0.1	0.1
Short access day 1 total inactive lever presses	0.4	0.5	0.6	-0.6	-0.7	-0.8	0.7	-0.7
Short access day 10 total inactive lever presses	0.4	0.4	0.5	-0.7	-0.7	-0.6	0.6	-0.6
Short access day 1 total infusions	0.6	0.6	1.3	-1.1	-0.8	0.3	-0.7	0.7
Short access day 10 total infusions	0.1	0.1	0.2	0.5	0.3	-0.2	0.4	-0.4
Short access total infusions	0.2	0.3	0.4	-0.6	-0.6	-0.5	0.4	-0.4
Short access day 1 locomotion	0.3	0.3	0.6	0.7	0.7	0.5	-0.3	0.3
Short access day 10 total locomotion	0.4	0.5	0.8	0.1	-0.1	-0.8	0.9	-0.9
Short access total locomotion	0.6	0.6	1.1	0.2	-0.1	-0.9	1.0	-1.1
Compulsive drug intake	0.4	0.4	1.2	1.1	0.9	0.1	0.1	-0.2
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.2	-0.3	-0.5	0.6	-0.6
One hour access (shock baseline)	0.0	0.0	0.1	-0.3	-0.3	0.0	-0.1	0.1
Number of responses in last shaping day	0.1	0.1	0.3	0.5	0.4	0.0	0.1	-0.1
Context. condit. distance diff. score	3.0	3.6	9.6	-3.1	-2.7	-1.0	0.2	-0.2
Locomotion velocity, session 1	0.2	0.2	0.3	0.6	0.6	0.4	-0.3	0.3
Locomotion distance, session 1	0.5	0.7	1.8	1.3	1.0	-0.2	0.6	-0.7
Locomotion velocity, session 2	0.2	0.3	0.6	0.7	0.5	-0.2	0.5	-0.5
Locomotion distance, session 2	1.1	1.6	4.2	2.0	1.5	-0.2	0.9	-0.9
Locomotion velocity, session 3	0.6	0.7	1.2	-0.8	-0.4	0.7	-1.1	1.1
Locomotion distance, session 3	0.3	0.4	1.0	-1.0	-0.8	-0.2	-0.1	0.1
Stereotopy head waving bouts, day 3	0.5	0.6	0.7	0.7	0.8	0.8	-0.8	0.8
Stereotopy head waving duration, day 3	2.2	2.7	3.0	1.5	1.7	1.7	-1.6	1.6
Locomotion velocity, session 7	7.0	7.7	15.6	-4.0	-3.7	-2.3	1.3	-1.3
Locomotion distance, session 7	4.6	5.8	10.7	-3.3	-3.2	-2.1	1.4	-1.4
Stereotopy head waving bouts, day 7	1.7	1.9	2.5	1.5	1.6	1.3	-1.2	1.2
Stereotopy head waving duration, day 7	2.1	2.6	3.0	1.4	1.7	1.7	-1.6	1.6
Locomotion velocity, session 8	0.3	0.3	0.9	-0.9	-0.8	-0.1	-0.2	0.2
Locomotion distance, session 8	0.6	0.8	0.9	-0.8	-0.9	-1.0	0.9	-0.9
Degree of sensitization distance	4.6	4.6	6.3	-2.4	-2.5	-2.2	1.8	-1.7
Degree of sensitization stereotypy	1.0	1.1	1.3	0.9	1.1	1.1	-1.1	1.1
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	1.1	1.0	0.6	-0.4	0.4
Condit. Reinf. active-inactive response ratio	1.4	1.6	2.4	0.5	0.8	1.4	-1.5	1.5
Condit. Reinf. active responses	0.4	0.5	1.5	1.2	0.9	-0.1	0.4	-0.4
Condit. Reinf. inactive responses	2.5	3.0	5.6	0.7	-0.0	-1.8	2.4	-2.4
Incentive salience index mean	1.2	1.5	3.4	1.8	1.7	0.9	-0.5	0.4
Condit. Reinf. lever presses	1.1	1.4	4.0	2.0	1.7	0.6	0.0	-0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.4	-0.2	0.2	-0.3	0.3
Time in novel zone, hab. session 1	0.9	0.9	1.6	0.0	0.4	1.1	-1.3	1.3
Total zone transitions, hab. session 1	0.4	0.6	1.6	1.3	1.1	0.5	-0.1	0.1
Total locomotion distance, hab. session 1	0.4	0.6	1.6	1.3	0.9	-0.1	0.6	-0.6
Locomotion velocity, hab. session 1	0.9	1.3	2.9	1.7	1.2	-0.4	1.0	-1.1
Time in familiar zone, hab. session 2	1.9	2.0	3.8	-0.7	-0.1	1.4	-1.9	1.9
Time in novel zone, hab. session 2	0.8	0.8	1.4	0.5	0.1	-0.9	1.2	-1.2
Total zone transitions, hab. session 2	2.2	2.9	5.9	2.4	2.3	1.3	-0.8	0.8
Total locomotion distance, hab. session 2	0.7	0.9	2.4	1.5	1.3	0.5	-0.1	0.1
Locomotion velocity, hab. session 2	1.2	1.6	4.0	2.0	1.8	0.8	-0.4	0.3
Novel to familiar place preference ratio	1.2	1.3	2.3	-0.0	-0.4	-1.3	1.5	-1.5
Novelty place preference	1.0	1.0	1.8	0.0	-0.3	-1.1	1.4	-1.4
Time in novel zone, NPP test	0.5	0.5	1.0	0.2	-0.1	-0.8	1.0	-1.0
Total zone transitions, NPP test	0.5	0.8	1.3	1.1	0.7	-0.5	0.9	-0.9
Total locomotion distance, NPP test	2.3	3.1	5.9	0.5	-0.2	-1.9	2.4	-2.4
Locomotion velocity, NPP test	2.1	3.1	5.7	0.5	-0.2	-1.9	2.4	-2.4
Pavlov. Cond. lever latency	0.2	0.3	0.7	-0.8	-0.6	-0.0	-0.3	0.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.3	-0.3
Pavlov. Cond. change in total contacts	1.2	1.3	2.1	1.5	1.4	1.0	-0.7	0.7
Pavlov. Cond. index score	0.2	0.2	0.6	0.8	0.7	0.3	-0.0	0.0
Pavlov. Cond. latency score	0.2	0.2	0.6	0.8	0.6	0.1	0.1	-0.1
Pavlov. Cond. lever contacts	0.2	0.3	0.7	0.8	0.6	-0.0	0.4	-0.4
Pavlov. Cond. magazine entry number	0.4	0.5	0.5	-0.6	-0.7	-0.7	0.7	-0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	1.0	0.7	-0.3	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.8	0.9	0.8	0.4	-0.2	0.2
Pavlov. Cond. response bias	0.2	0.2	0.4	0.6	0.6	0.4	-0.3	0.3
Bone: apparent density	1.0	1.7	2.6	-0.5	-0.9	-1.5	1.6	-1.6
Bone surface	0.4	0.8	1.4	0.2	-0.2	-1.0	1.2	-1.2
Bone volume	0.5	0.9	1.6	0.0	-0.3	-1.1	1.3	-1.3
Bone: connectivity density	2.1	3.3	4.3	-1.2	-1.5	-2.1	2.1	-2.1
Bone: cortical apparent density	1.1	1.5	4.2	-2.0	-1.6	-0.1	-0.4	0.5
Bone: cortical area	0.0	0.1	0.1	0.4	0.3	-0.1	0.2	-0.2
Bone: cortical porosity	2.1	2.3	4.5	2.1	2.0	1.2	-0.8	0.8
Bone: cortical porosity	1.4	1.5	3.7	1.9	1.7	0.8	-0.3	0.3
Bone: cortical thickness	0.0	0.0	0.0	-0.1	-0.2	-0.2	0.2	-0.2
Bone: cortical thickness	0.4	0.5	1.4	-1.2	-1.0	-0.2	-0.1	0.1
Bone: cortical tissue density	1.2	1.5	4.4	-2.1	-1.7	-0.1	-0.5	0.5
Bone: elastic displacement	0.7	0.8	1.4	0.5	0.2	-0.9	1.2	-1.2
Bone: elastic work	1.0	1.3	2.1	1.4	0.9	-0.7	1.2	-1.2
Bone: endosteal estimation	0.2	0.4	0.8	0.9	0.9	0.5	-0.4	0.4
Bone: endosteal perimeter	0.3	0.5	1.4	1.2	1.1	0.4	-0.1	0.1
Bone: final force	0.1	0.2	0.2	0.4	0.5	0.4	-0.4	0.4
Bone: final moment	0.2	0.3	0.6	0.8	0.7	0.3	-0.2	0.2
Bone: marrow area	0.1	0.3	0.7	0.8	0.8	0.4	-0.3	0.2
Bone: maximum diameter	0.3	0.5	0.7	0.3	0.5	0.8	-0.8	0.8
Bone: maximum force	0.3	0.5	1.0	1.0	1.0	0.6	-0.4	0.4
Bone: maximum moment	0.4	0.6	1.7	1.3	1.1	0.4	-0.1	0.1
Bone: minimum diameter	0.4	0.8	2.1	1.5	1.3	0.5	-0.1	0.1
Bone: periosteal estimation	0.1	0.2	0.5	0.7	0.6	0.3	-0.1	0.1
Bone: periosteal perimeter	0.1	0.1	0.4	0.6	0.5	0.1	0.0	-0.0
Bone: post-yield work	0.3	0.4	1.0	-1.0	-0.9	-0.4	0.2	-0.2
Bone: stiffness	0.5	0.7	1.0	0.6	0.8	0.9	-1.0	1.0
Bone: tissue strength	0.1	0.1	0.2	0.3	0.2	-0.3	0.4	-0.4
Bone: trabecular number	1.9	2.9	4.2	-0.8	-1.3	-1.9	2.0	-2.0
Bone: trabecular spacing	1.8	2.4	3.2	1.0	1.3	1.7	-1.8	1.8
Bone: trabecular thickness	0.9	1.1	1.9	-0.2	-0.6	-1.2	1.4	-1.4
Bone: trabecular tissue density	1.1	1.6	1.8	1.2	1.4	1.3	-1.2	1.2
Breakpoint value in progressive ratio session	0.0	0.0	0.0	0.1	0.1	0.1	-0.2	0.2
Distance traveled before self-admin	1.7	1.8	3.6	1.9	1.8	1.2	-0.7	0.7
Distance traveled after self-admin	1.7	1.9	3.0	0.4	0.8	1.6	-1.7	1.7
Delta time in closed arm before/after self-admin	1.6	1.6	2.7	-0.0	-0.4	-1.4	1.7	-1.7
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.6	-0.5	-0.1	0.0	-0.0
Diff in mean of infusions in LGA sessions	2.0	2.3	3.2	0.8	1.1	1.8	-1.8	1.8
Extinction: sum of active levers before priming	2.2	2.2	2.7	-1.4	-1.5	-1.6	1.5	-1.5
Active lever presses in extinction session 6	0.6	0.5	0.9	-1.0	-0.9	-0.7	0.4	-0.4
Delta distance traveled before/after self-admin	2.2	2.3	4.4	-0.8	-0.2	1.4	-2.1	2.1
Delta ambulatory time before/after self-admin	1.9	2.0	4.0	-0.5	0.1	1.4	-2.0	2.0
Time in closed arm before self-admin	1.3	1.5	2.6	0.2	0.6	1.4	-1.6	1.6
Time in closed arm after self-admin	0.4	0.5	0.6	0.5	0.6	0.7	-0.7	0.7
Time in open arm before self-admin	0.2	0.2	0.4	0.6	0.6	0.4	-0.3	0.3
Time in open arm after self-admin	0.0	0.0	0.1	-0.0	-0.1	-0.2	0.3	-0.3
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.6	-1.3	-1.0	-0.3	-0.2	0.2
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.0	-0.4	-0.6	-1.0	1.0	-1.0
Time to tail flick, vehicle, after self-admin	1.5	1.6	3.0	-0.4	0.1	1.4	-1.7	1.7
Time to tail flick, test, before self-admin	0.7	0.7	1.4	0.3	-0.1	-0.9	1.2	-1.2
Time to tail flick, test, after self-admin	3.8	3.9	5.8	-2.3	-2.4	-1.9	1.5	-1.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.9	-0.8	-0.4	0.6	-0.9	0.9
Delta time to tail flick, test, before/after SA	1.9	1.7	4.8	-2.2	-1.9	-0.5	0.0	0.0
Ambulatory time before self-admin	1.0	1.1	2.2	1.5	1.4	0.9	-0.5	0.5
Ambulatory time after self-admin	2.9	3.2	4.4	1.0	1.4	2.1	-2.1	2.1
Total heroin consumption	0.4	0.5	0.8	0.9	0.9	0.6	-0.5	0.4
Area under the delay curve	0.0	0.0	0.1	0.3	0.3	-0.0	-0.1	0.1
Delay disc. indifference point, 0s delay	0.5	0.6	0.9	0.7	0.3	-0.6	1.0	-1.0
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.3	-0.4	-0.7	0.5	-0.5
Delay disc. indifference point, 2s delay	1.5	1.7	2.6	1.6	1.6	1.2	-1.0	1.0
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.3	-0.1	0.3	-0.6	0.6
Delay disc. indifference point, 4s delay	1.1	1.2	1.8	0.5	0.8	1.3	-1.3	1.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	0.1	-0.0	-0.3	0.3	-0.3
Delay discount exponential model param	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.4	-0.4
Delay discount hyperbolic model param	0.4	0.4	0.5	-0.7	-0.7	-0.5	0.6	-0.6
Fecal boli incidents, locomotor time 1	0.7	0.8	1.0	0.9	1.0	0.9	-0.7	0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.2	-0.1	0.3	-0.4	0.4
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.4	-0.2	-0.5	-1.0	1.2	-1.2
Bouts of movement, locomotor time 1	3.6	4.0	5.9	0.8	1.4	2.4	-2.4	2.4
Total resting periods, locomotor time 1	3.6	4.0	6.5	0.5	1.1	2.4	-2.5	2.5
Rest time, locomotor task time 1	2.5	2.8	4.2	0.7	1.1	2.0	-2.0	2.0
Distance moved, locomotor task time 1	2.5	2.8	3.9	-1.0	-1.4	-2.0	1.9	-1.9
Vertical activity count, locomotor time 1	1.0	1.1	1.9	0.7	0.2	-1.0	1.4	-1.4
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.5	0.5	0.6	0.7	-0.6	0.6
Bouts of movement, locomotor time 2	2.9	3.1	5.1	0.3	0.9	2.1	-2.3	2.3
Total resting periods, locomotor time 2	3.4	3.7	6.2	0.3	0.9	2.3	-2.5	2.5
Rest time, locomotor task time 2	1.2	1.4	2.6	-0.6	-0.1	1.2	-1.6	1.6
Distance moved, locomotor task time 2	2.3	2.7	4.9	0.2	-0.4	-1.9	2.2	-2.2
Vertical activity count, locomotor time 2	0.9	0.9	1.5	1.2	0.8	-0.6	1.0	-1.1
Weight adjusted by age	1.5	1.7	2.1	1.3	1.4	1.3	-1.2	1.2
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	1.8	-0.1	-0.5	-1.2	1.3	-1.3
Locomotion in novel chamber	0.3	0.3	0.6	0.3	0.1	-0.6	0.7	-0.8
Locomotion in novel chamber post-restriction	0.4	0.5	0.7	0.3	0.5	0.8	-0.9	0.9
Progressive ratio	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.3	-0.3
Food seeking constrained by brief footshock	2.1	2.5	3.9	-1.7	-0.9	1.2	-2.0	2.0
Seeking ratio, punishment vs. effort	0.8	1.0	1.8	-0.4	-0.0	1.1	-1.3	1.3
Run reversals in cocaine runway, females	3.1	3.0	4.3	-0.9	-1.3	-2.0	2.1	-2.1
Run reversals in cocaine runway, males	1.9	1.8	2.4	1.0	1.2	1.5	-1.5	1.5
Latency to leave start box in cocaine runway	0.6	0.6	0.9	0.6	0.7	1.0	-0.8	0.8
Latency to leave start box in cocaine runway, F	1.4	1.6	2.1	1.1	1.3	1.5	-1.2	1.2
Latency to leave start box in cocaine runway, M	0.9	0.9	1.3	-0.4	-0.6	-1.1	1.1	-1.2
Cd content in liver	0.3	0.3	0.4	-0.6	-0.6	-0.5	0.5	-0.5
Co content in liver	3.0	3.5	6.1	0.1	0.7	2.2	-2.5	2.5
Cu content in liver	0.4	0.5	0.8	0.2	0.4	0.8	-0.9	0.9
Fe content in liver	1.6	1.9	2.6	-0.8	-1.1	-1.6	1.6	-1.6
K content in liver	0.6	0.6	0.8	-0.8	-0.9	-0.8	0.7	-0.7
Mg content in liver	1.2	1.2	1.6	-1.2	-1.3	-1.1	1.0	-1.0
Mn content in liver	1.6	1.8	2.5	-0.7	-1.0	-1.5	1.6	-1.6
Na content in liver	2.8	3.0	8.1	2.8	2.5	0.8	-0.1	0.1
Rb content in liver	0.7	0.9	2.3	-1.5	-1.3	-0.5	0.2	-0.1
Se content in liver	1.8	2.1	3.0	1.6	0.9	-1.1	1.7	-1.7
Sr content in liver	0.3	0.3	0.6	-0.1	-0.3	-0.5	0.8	-0.8
Zn content in liver	1.9	2.1	4.9	2.2	2.0	1.0	-0.5	0.5