Hub : Genes

Fhip2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000012014	0.02	0.02	3.9e-03	0.01	0.01	0	0.01	3.2e-02	3.3e-02	9.4e-02	2.8e-02
2	Adipose	isoform ratio	ENSRNOT00000097198	0.02	0.01	5.0e-03	0.01	0	0	0	3.6e-02	1.2e-01	2.2e-01	1.9e-01
3	Liver	gene expression	ENSRNOG00000012014	0.08	0.06	7.9e-04	0.02	0.02	0.01	0.02	6.4e-03	1.0e-03	9.9e-03	1.9e-03
4	NAcc	intron excision ratio	chr15:45658567:45658743	0.04	0.04	8.5e-03	0	0	-0	0	2.2e-01	1.9e-01	7.0e-01	3.3e-01
5	NAcc	intron excision ratio	chr15:45658883:45659175	0.06	0.05	7.9e-03	0.01	0	0	0	1.0e-01	3.3e-01	3.0e-01	3.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	0.8	2.5	3.8	1.1	1.2	1.9	-1.6	1.9
BMI without tail	0.4	0.9	1.6	-1.1	-1.3	0.8	0.9	0.1
Body weight	0.3	1.2	2.2	1.5	1.3	0.0	-1.3	0.7
Epididymis fat weight	1.5	3.4	5.4	-2.2	-2.3	-0.4	2.2	-1.4
Glucose	0.4	0.6	1.8	-0.0	-0.2	1.4	-0.2	1.1
Heart weight	0.1	0.2	0.6	0.0	-0.1	-0.8	0.3	-0.6
Left kidney weight	0.2	0.6	1.2	1.1	1.0	-0.6	-0.8	0.1
Right kidney weight	0.5	1.5	3.8	-0.4	-0.5	-2.0	0.9	-1.6
Tail length	1.1	3.2	4.0	-1.4	-1.7	-1.9	1.9	-2.0
Length with tail	0.3	0.9	3.1	0.8	0.5	-1.8	-0.1	-0.9
Length without tail	2.4	5.2	9.0	3.0	2.9	-0.2	-2.6	1.2
Liver weight, left	1.5	2.4	3.7	1.8	1.9	0.4	-1.8	1.1
Liver weight, right	0.6	1.0	1.4	1.0	1.1	0.7	-1.2	1.0
Parametrial fat weight	2.2	4.4	6.6	-2.6	-2.5	-0.5	2.5	-1.6
Retroperitoneal fat weight	0.1	0.5	1.1	-0.6	-0.7	1.1	0.4	0.5
Intraocular pressure	0.5	0.8	1.0	-1.0	-0.9	-0.5	1.0	-0.9
Extensor digitorum longus weight	9.0	36.1	50.2	7.1	7.1	2.3	-7.1	5.0
Soleus weight	1.0	2.8	3.4	1.8	1.7	1.2	-1.8	1.8
Tibialis anterior weight	5.5	18.9	28.7	5.4	5.3	1.1	-5.1	3.2
Tibia length	3.2	9.0	15.8	-1.9	-1.8	-4.0	2.6	-3.9
Number of licking bursts	0.1	0.1	0.3	0.1	0.1	0.5	-0.2	0.5
Food consumed during 24 hour testing period	0.9	1.0	2.1	-0.6	-0.5	-1.5	0.8	-1.3
Times rat made contact with spout	0.2	0.3	0.5	-0.7	-0.7	0.2	0.6	-0.1
Mean time between licks in bursts	2.0	2.7	3.4	-1.8	-1.7	-1.2	1.8	-1.7
Mean num. licks in bursts	0.3	0.4	0.5	-0.7	-0.7	-0.2	0.7	-0.6
Std. dev. time between licks in bursts	3.6	4.3	7.5	-1.4	-1.3	-2.7	1.8	-2.7
Water consumed over 24 hours	0.8	0.9	1.6	1.3	1.3	-0.2	-1.1	0.5
Indifference point 0 sec	5.1	8.2	14.5	-1.8	-1.9	-3.8	2.6	-3.6
Indifference point AUC	1.0	1.1	1.8	0.8	0.7	1.4	-1.0	1.3
Indifference point function ln k	0.6	0.8	2.4	-0.2	-0.1	-1.6	0.5	-1.2
Indifference point function log k	0.6	0.8	2.4	-0.2	-0.1	-1.6	0.5	-1.2
Delay discounting total patch changes 0 sec	4.6	7.4	13.7	-1.6	-1.7	-3.7	2.4	-3.4
Delay discounting total patch changes 12 sec	1.8	2.3	4.0	-0.9	-1.0	-2.0	1.4	-2.0
Delay discounting total patch changes 18 sec	1.9	2.5	3.2	-1.6	-1.7	-1.1	1.8	-1.6
Delay discounting total patch changes 24 sec	1.1	1.3	4.3	0.0	-0.2	-2.1	0.6	-1.4
Delay discounting total patch changes 6 sec	0.3	0.5	0.6	-0.6	-0.7	-0.7	0.8	-0.8
Delay discounting time to switch 0 sec	0.5	0.7	1.2	-1.1	-1.1	-0.1	1.0	-0.6
Delay discounting water rate 0 sec	0.2	0.4	0.6	0.7	0.8	-0.7	-0.5	-0.2
Delay discounting water rate 12 sec	0.4	0.5	1.1	0.8	1.0	-0.6	-0.8	0.1
Delay discounting water rate 18 sec	2.6	3.5	4.7	2.0	2.1	1.0	-2.2	1.8
Delay discounting water rate 24 sec	0.5	0.7	1.5	0.3	0.4	1.2	-0.6	1.2
Delay discounting water rate 6 sec	1.2	1.7	3.1	1.7	1.8	-0.9	-1.4	0.2
Locomotor activity	2.7	4.3	12.0	1.7	1.6	-3.5	-0.6	-1.9
Locomotor testing distance	3.0	5.0	15.5	0.2	-0.0	-3.9	0.9	-3.0
Locomotor testing rearing	5.2	8.1	23.4	-0.3	-0.6	-4.8	1.6	-3.7
Light reinforcement 1	2.0	3.6	6.2	-2.5	-2.5	0.4	2.2	-0.9
Light reinforcement 2	1.5	2.0	4.8	-1.4	-1.3	2.2	0.7	0.9
Reaction time number correct	0.9	1.3	1.8	1.0	0.9	1.2	-1.1	1.4
Reaction time mean minus median	0.3	0.4	1.0	0.6	0.4	-1.0	-0.2	-0.4
Reaction time mean minus median AUC	0.1	0.2	0.4	0.6	0.4	-0.6	-0.2	-0.2
Reaction time num false alarms	0.1	0.1	0.2	0.4	0.3	-0.4	-0.2	0.0
Reaction time num false alarms AUC	0.0	0.0	0.1	0.3	0.1	-0.4	-0.0	-0.0
Reaction time trials correct on left	0.9	1.3	1.8	1.0	0.9	1.2	-1.1	1.4
Reaction time trials on left	0.8	1.1	1.6	0.9	0.8	1.2	-1.0	1.3
Reaction time mean	0.1	0.2	0.3	0.6	0.4	-0.6	-0.3	-0.1
Reaction time mean AUC	0.3	0.4	0.6	0.8	0.6	-0.7	-0.4	-0.1
Median of all reaction times	0.1	0.1	0.2	0.5	0.2	-0.3	-0.1	0.1
Reaction time omissions	1.6	2.1	3.2	-1.6	-1.8	-0.6	1.8	-1.1
Reaction time false alarm rate	0.1	0.2	0.3	-0.3	-0.4	-0.5	0.4	-0.5
Reaction time premature initiation rate	2.0	2.7	3.9	1.4	1.3	1.8	-1.7	2.0
Reaction time premature initiations	3.2	4.6	6.7	1.8	1.7	2.3	-2.1	2.6
Std. dev. reaction times	0.2	0.3	0.7	0.6	0.4	-0.8	-0.2	-0.3
Reaction time trials completed	0.8	1.1	1.6	0.9	0.8	1.2	-1.0	1.3
Reaction time trials AUC	0.7	1.0	1.5	0.9	0.8	1.2	-1.0	1.2
Social response proportion	2.1	2.3	7.3	0.1	0.3	2.7	-0.9	1.9
Social responses	0.7	0.9	1.6	-1.2	-1.2	0.4	1.0	-0.4
Social time	0.9	1.1	2.1	-0.5	-0.7	-1.5	1.0	-1.4
Conditioned locomotion	0.2	0.2	0.7	-0.3	-0.2	0.8	-0.0	0.5
Cocaine response after cond. corrected	1.8	2.1	5.1	0.4	0.5	2.3	-1.0	1.9
Cocaine response after cond. not corrected	0.8	0.9	2.3	0.3	0.4	1.5	-0.7	1.2
Cocaine response before conditioning	1.4	1.7	4.1	-0.4	-0.4	-2.0	0.9	-1.8
Saline control response	0.6	0.8	1.5	-0.5	-0.5	-1.2	0.8	-1.1
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.7	-0.6	-0.2	0.6	-0.5
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	0.3	0.4	0.8	-0.5	0.7
Condit. Reinf. active responses	0.7	1.0	1.3	-1.1	-1.1	-0.6	1.2	-1.0
Condit. Reinf. inactive responses	2.2	2.8	3.5	-1.6	-1.7	-1.3	1.9	-1.8
Condit. Reinf. lever presses	0.9	1.3	3.4	-0.2	-0.3	-1.9	0.7	-1.5
Condit. Reinf. lever reinforcers received	0.5	0.8	0.9	-0.9	-0.9	-0.6	1.0	-0.9
Pavlov. Cond. lever latency	0.7	0.9	2.7	-0.8	-0.7	1.6	0.2	0.9
Pavlov. Cond. magazine entry latency	0.7	0.8	2.4	-0.1	-0.3	-1.5	0.6	-1.2
Pavlov. Cond. change in total contacts	1.0	1.4	2.4	1.5	1.5	-1.0	-1.1	-0.0
Pavlov. Cond. index score	0.8	1.1	3.1	0.9	0.8	-1.7	-0.3	-0.9
Pavlov. Cond. latency score	0.9	1.1	3.5	0.7	0.6	-1.9	-0.1	-1.1
Pavlov. Cond. lever contacts	1.0	1.4	4.3	0.8	0.7	-2.1	-0.2	-1.2
Pavlov. Cond. magazine entry number	0.4	0.5	1.4	0.0	0.2	1.2	-0.5	0.9
Pavlov. Cond. intertrial magazine entries	4.5	5.8	8.0	-2.8	-2.8	-1.1	2.8	-2.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.3	1.0	0.9	-1.5	-0.4	-0.6
Pavlov. Cond. response bias	1.0	1.4	4.4	0.8	0.8	-2.1	-0.2	-1.2
Conditioned reinforcement - actives	1.6	1.6	3.0	-1.7	-1.7	0.7	1.4	-0.3
Conditioned reinforcement - inactives	2.6	3.0	3.9	-1.8	-1.8	-1.2	2.0	-1.7
Conditioned locomotion	0.7	0.9	1.6	-1.3	-1.1	-0.0	1.0	-0.7
Intermittent access intake day 1-15 change	1.5	1.5	2.1	-1.3	-1.4	-0.6	1.5	-1.1
Intermittent access intake escalation	0.8	0.8	1.3	-1.0	-1.1	-0.3	1.1	-0.7
Intermittent access intake escalation 2	0.3	0.3	0.4	-0.6	-0.6	-0.1	0.6	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.3	-0.3	0.0	0.2	-0.2
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.8	-0.0	-0.1	-0.9	0.3	-0.5
Intermitt. access escalation Index	0.6	0.5	0.6	0.7	0.6	0.6	-0.7	0.8
Intermittent access day 1 total infusions	0.0	0.1	0.2	-0.4	-0.2	0.1	0.1	-0.0
Intermittent access day 15 total infusions	0.6	0.7	1.2	-1.1	-1.0	-0.0	1.0	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.3	-0.6	-0.4	0.6	0.3	0.2
Intermittent access total infusions	0.3	0.3	0.6	-0.8	-0.7	0.6	0.5	0.1
Intermittent access day 1 locomotion	0.4	0.4	0.6	-0.6	-0.6	-0.7	0.7	-0.7
Intermittent access day 15 total locomotion	0.9	1.0	1.7	-1.3	-1.3	0.1	1.2	-0.5
Intermittent access total locomotion	0.4	0.4	0.6	-0.8	-0.7	-0.4	0.7	-0.6
Intermittent access standard deviation	1.1	1.2	1.5	-1.2	-1.1	-0.8	1.2	-1.1
Cocaine induced anxiety	1.4	1.6	5.4	0.4	0.4	-2.3	0.2	-1.5
Post-drug Anxiety	1.2	1.3	2.3	-0.8	-0.7	-1.5	1.0	-1.4
Baseline Anxiety	0.5	0.5	1.0	-1.0	-0.9	0.5	0.7	-0.1
Lifetime Intake	0.3	0.3	0.6	-0.8	-0.7	0.5	0.5	0.0
Incentive Sensitization - Responses	0.6	0.6	1.1	-1.0	-1.0	0.1	0.9	-0.3
Incentive Sensitization - Breakpoint	0.9	0.9	1.5	-1.2	-1.2	-0.2	1.1	-0.6
Progressive ratio test 1 active lever presses	1.7	1.7	4.3	0.5	0.5	2.1	-0.9	1.7
Progressive ratio test 1 breakpoint	1.6	1.7	4.9	0.3	0.3	2.2	-0.8	1.7
Progressive ratio test 1 inactive lever presses	1.0	1.0	1.8	-1.3	-1.3	0.2	1.2	-0.5
Progressive ratio test 2 active lever presses	1.0	1.1	3.5	-0.5	-0.5	1.9	-0.0	1.2
Progressive ratio test 2 breakpoint	0.5	0.5	1.6	-0.6	-0.5	1.3	0.2	0.7
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.5	-0.7	-0.7	-0.1	0.6	-0.3
Total sessions with >9 infusions	0.3	0.3	1.0	-0.2	-0.1	1.0	-0.1	0.6
Short access day 1 total inactive lever presses	0.3	0.4	0.6	-0.8	-0.8	-0.0	0.7	-0.3
Short access day 10 total inactive lever presses	0.2	0.2	0.4	-0.6	-0.6	0.2	0.6	-0.2
Short access day 1 total infusions	1.2	1.2	3.5	0.2	0.3	1.9	-0.7	1.4
Short access day 10 total infusions	0.2	0.2	0.6	-0.2	-0.2	-0.8	0.3	-0.6
Short access total infusions	0.1	0.1	0.3	-0.5	-0.5	0.3	0.4	-0.1
Short access day 1 locomotion	0.1	0.1	0.2	0.5	0.5	-0.5	-0.3	-0.1
Short access day 10 total locomotion	0.7	0.8	1.1	-0.7	-0.8	-1.0	1.0	-1.0
Short access total locomotion	1.0	1.0	1.4	-0.8	-0.9	-1.2	1.1	-1.2
Compulsive drug intake	0.5	0.4	1.6	0.3	0.1	-1.3	0.2	-0.7
One hour access (0.3 mA shock)	0.2	0.3	0.4	-0.6	-0.5	-0.4	0.6	-0.5
One hour access (shock baseline)	0.0	0.1	0.2	-0.1	0.0	0.4	-0.1	0.3
Number of responses in last shaping day	0.1	0.1	0.4	0.0	0.0	-0.6	0.1	-0.5
Context. condit. distance diff. score	2.2	2.7	8.5	-1.0	-1.0	2.9	0.3	1.7
Locomotion velocity, session 1	0.1	0.1	0.1	0.4	0.4	-0.3	-0.3	-0.1
Locomotion distance, session 1	1.0	1.3	3.7	-0.2	-0.2	-1.9	0.6	-1.5
Locomotion velocity, session 2	0.4	0.5	1.3	-0.2	-0.2	-1.1	0.4	-1.0
Locomotion distance, session 2	1.9	2.7	7.9	-0.2	-0.2	-2.8	0.8	-2.2
Locomotion velocity, session 3	1.5	1.7	3.3	0.7	0.7	1.8	-1.1	1.8
Locomotion distance, session 3	0.4	0.4	1.2	-0.2	-0.2	1.1	-0.1	0.8
Stereotopy head waving bouts, day 3	0.4	0.5	0.8	0.9	0.8	0.1	-0.8	0.5
Stereotopy head waving duration, day 3	1.6	1.9	3.4	1.8	1.7	-0.1	-1.6	0.8
Locomotion velocity, session 7	3.8	4.1	7.8	-2.1	-2.3	2.8	1.4	1.1
Locomotion distance, session 7	2.3	3.0	4.5	-2.0	-2.1	2.0	1.4	0.6
Stereotopy head waving bouts, day 7	1.0	1.1	2.2	1.5	1.3	-0.5	-1.2	0.4
Stereotopy head waving duration, day 7	1.6	1.9	3.3	1.8	1.7	-0.0	-1.6	0.9
Locomotion velocity, session 8	0.3	0.4	1.3	-0.2	-0.1	1.1	-0.2	0.7
Locomotion distance, session 8	0.4	0.6	1.0	-1.0	-1.0	0.0	0.9	-0.5
Degree of sensitization distance	2.6	2.6	4.8	-2.1	-2.2	0.9	1.8	-0.4
Degree of sensitization stereotypy	0.8	0.8	1.3	1.2	1.1	0.0	-1.1	0.6
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	0.6	0.6	-0.7	-0.4	-0.2
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.4	1.4	1.4	0.9	-1.6	1.3
Condit. Reinf. active responses	0.7	0.8	2.6	-0.1	-0.1	-1.6	0.4	-1.2
Condit. Reinf. inactive responses	4.9	5.7	8.6	-1.9	-1.8	-2.8	2.3	-2.9
Incentive salience index mean	0.7	0.9	2.2	0.8	0.9	-1.5	-0.5	-0.7
Condit. Reinf. lever presses	1.0	1.3	4.1	0.4	0.6	-2.0	-0.0	-1.4
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.2	0.2	0.7	-0.3	0.5
Time in novel zone, hab. session 1	1.5	1.5	2.2	1.1	1.1	1.1	-1.3	1.5
Total zone transitions, hab. session 1	0.3	0.4	1.3	0.4	0.5	-1.1	-0.2	-0.6
Total locomotion distance, hab. session 1	0.7	1.0	3.1	-0.2	-0.1	-1.8	0.5	-1.3
Locomotion velocity, hab. session 1	1.8	2.6	7.0	-0.5	-0.4	-2.6	1.0	-2.1
Time in familiar zone, hab. session 2	3.9	4.1	6.3	1.4	1.4	2.5	-1.9	2.5
Time in novel zone, hab. session 2	1.6	1.6	2.5	-0.9	-0.9	-1.6	1.2	-1.6
Total zone transitions, hab. session 2	1.2	1.5	3.0	1.3	1.3	-1.7	-0.8	-0.6
Total locomotion distance, hab. session 2	0.5	0.6	2.0	0.5	0.5	-1.4	-0.2	-0.8
Locomotion velocity, hab. session 2	0.7	1.0	2.9	0.8	0.8	-1.7	-0.4	-0.8
Novel to familiar place preference ratio	1.9	2.0	2.6	-1.2	-1.3	-1.4	1.5	-1.6
Novelty place preference	1.5	1.6	2.1	-1.1	-1.1	-1.3	1.4	-1.5
Time in novel zone, NPP test	0.9	1.0	1.4	-0.8	-0.8	-1.1	1.0	-1.2
Total zone transitions, NPP test	1.2	1.7	4.1	-0.5	-0.5	-2.0	0.9	-1.7
Total locomotion distance, NPP test	4.2	5.8	8.5	-1.9	-1.9	-2.7	2.4	-2.9
Locomotion velocity, NPP test	3.9	5.6	8.3	-1.9	-1.9	-2.6	2.4	-2.9
Pavlov. Cond. lever latency	0.3	0.4	1.2	0.1	-0.0	1.1	-0.3	0.9
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.3	-0.2
Pavlov. Cond. change in total contacts	0.6	0.6	1.1	0.9	1.0	-0.8	-0.8	-0.1
Pavlov. Cond. index score	0.1	0.2	0.6	0.2	0.3	-0.8	-0.1	-0.4
Pavlov. Cond. latency score	0.2	0.2	0.8	0.0	0.1	-0.9	0.1	-0.6
Pavlov. Cond. lever contacts	0.4	0.5	1.3	-0.2	-0.0	-1.2	0.3	-0.9
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	-0.7	-0.7	0.1	0.7	-0.4
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.6	-0.3	-0.3	-1.6	0.6	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.4	0.4	-0.7	-0.2	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	0.4	-0.4	-0.3	-0.1
Bone: apparent density	1.2	1.9	2.6	-1.5	-1.5	-0.9	1.6	-1.3
Bone surface	0.7	1.3	1.8	-1.0	-1.0	-1.2	1.2	-1.3
Bone volume	0.8	1.4	1.7	-1.0	-1.1	-1.2	1.3	-1.3
Bone: connectivity density	2.0	3.1	4.3	-2.1	-2.1	-0.7	2.1	-1.5
Bone: cortical apparent density	1.5	2.0	6.3	-0.1	-0.2	2.5	-0.4	1.9
Bone: cortical area	0.1	0.1	0.2	-0.1	-0.1	-0.5	0.2	-0.4
Bone: cortical porosity	1.1	1.2	2.1	1.1	1.3	-1.4	-0.8	-0.5
Bone: cortical porosity	0.9	0.9	2.7	0.7	0.8	-1.6	-0.3	-0.9
Bone: cortical thickness	0.0	0.0	0.1	-0.3	-0.2	0.0	0.2	-0.0
Bone: cortical thickness	0.4	0.5	1.7	-0.2	-0.2	1.3	-0.1	0.8
Bone: cortical tissue density	1.6	2.1	6.7	-0.1	-0.1	2.6	-0.5	1.9
Bone: elastic displacement	1.4	1.6	2.6	-0.8	-0.9	-1.6	1.1	-1.6
Bone: elastic work	2.1	2.7	6.5	-0.6	-0.7	-2.5	1.2	-2.2
Bone: endosteal estimation	0.1	0.2	0.4	0.6	0.5	-0.6	-0.4	-0.2
Bone: endosteal perimeter	0.2	0.4	1.2	0.5	0.4	-1.1	-0.1	-0.6
Bone: final force	0.1	0.1	0.2	0.5	0.4	-0.0	-0.4	0.3
Bone: final moment	0.1	0.1	0.3	0.4	0.3	-0.6	-0.2	-0.2
Bone: marrow area	0.1	0.2	0.4	0.5	0.4	-0.6	-0.2	-0.3
Bone: maximum diameter	0.3	0.5	0.7	0.8	0.8	0.5	-0.8	0.7
Bone: maximum force	0.1	0.2	0.3	0.6	0.6	-0.6	-0.4	-0.1
Bone: maximum moment	0.2	0.4	1.3	0.4	0.4	-1.2	-0.1	-0.7
Bone: minimum diameter	0.3	0.5	1.7	0.4	0.5	-1.3	-0.2	-0.8
Bone: periosteal estimation	0.1	0.1	0.3	0.3	0.3	-0.6	-0.1	-0.3
Bone: periosteal perimeter	0.1	0.1	0.3	0.1	0.1	-0.6	0.0	-0.4
Bone: post-yield work	0.2	0.3	0.8	-0.5	-0.4	0.9	0.2	0.5
Bone: stiffness	0.4	0.7	1.0	1.0	0.9	0.3	-1.0	0.8
Bone: tissue strength	0.2	0.2	0.4	-0.3	-0.3	-0.7	0.4	-0.6
Bone: trabecular number	2.0	3.1	4.2	-1.9	-2.0	-1.0	2.1	-1.7
Bone: trabecular spacing	1.8	2.3	3.2	1.8	1.7	0.7	-1.8	1.3
Bone: trabecular thickness	1.3	1.5	1.9	-1.2	-1.2	-1.0	1.4	-1.3
Bone: trabecular tissue density	0.7	1.0	1.8	1.3	1.3	-0.1	-1.2	0.5
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.3	0.2	0.1	-0.2	0.1
Distance traveled before self-admin	0.9	1.0	1.9	1.1	1.1	-1.4	-0.6	-0.6
Distance traveled after self-admin	2.0	2.2	2.9	1.6	1.6	1.1	-1.7	1.4
Delta time in closed arm before/after self-admin	2.7	2.7	3.0	-1.5	-1.5	-1.6	1.7	-1.7
Delta time in open arm before/after self-admin	0.1	0.1	0.4	-0.0	-0.0	0.6	-0.0	0.3
Diff in mean of infusions in LGA sessions	2.2	2.5	3.6	1.9	1.7	0.9	-1.8	1.4
Extinction: sum of active levers before priming	1.6	1.6	2.8	-1.6	-1.7	0.0	1.5	-0.7
Active lever presses in extinction session 6	0.3	0.3	0.5	-0.7	-0.6	0.5	0.5	0.0
Delta distance traveled before/after self-admin	4.4	4.7	7.4	1.5	1.6	2.7	-2.1	2.7
Delta ambulatory time before/after self-admin	3.6	3.9	5.6	1.5	1.6	2.3	-2.0	2.4
Time in closed arm before self-admin	2.2	2.5	3.0	1.5	1.6	1.5	-1.7	1.6
Time in closed arm after self-admin	0.4	0.4	0.6	0.8	0.8	0.2	-0.8	0.5
Time in open arm before self-admin	0.1	0.1	0.3	0.5	0.2	-0.5	-0.2	0.0
Time in open arm after self-admin	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.3	-0.4
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.8	-0.1	-0.4	1.3	-0.1	0.9
Time to tail flick, vehicle, before self-admin	0.6	0.7	0.9	-0.9	-0.8	-0.5	1.0	-0.8
Time to tail flick, vehicle, after self-admin	2.9	3.1	4.5	1.4	1.4	2.0	-1.8	2.1
Time to tail flick, test, before self-admin	1.3	1.3	1.8	-0.8	-1.0	-1.4	1.2	-1.2
Time to tail flick, test, after self-admin	2.0	2.1	4.1	-2.0	-1.8	1.1	1.5	-0.1
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	2.7	0.6	0.5	1.6	-0.9	1.5
Delta time to tail flick, test, before/after SA	1.7	1.5	5.3	-0.7	-0.4	2.3	-0.1	1.2
Ambulatory time before self-admin	0.6	0.6	1.2	0.8	0.8	-1.1	-0.5	-0.5
Ambulatory time after self-admin	2.8	3.1	4.3	2.0	2.0	0.9	-2.1	1.5
Total heroin consumption	0.2	0.3	0.4	0.6	0.7	-0.5	-0.5	-0.1
Area under the delay curve	0.0	0.0	0.1	0.1	0.1	-0.3	-0.0	-0.3
Delay disc. indifference point, 0s delay	1.2	1.3	2.5	-0.5	-0.6	-1.6	1.0	-1.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.6	-0.5	-0.1	0.5	-0.6
Delay disc. indifference point, 2s delay	0.9	1.0	1.9	1.4	1.3	-0.7	-1.0	0.1
Delay disc. indifference point, 24s delay	0.4	0.4	0.7	0.4	0.4	0.8	-0.5	0.8
Delay disc. indifference point, 4s delay	1.1	1.2	1.7	1.2	1.2	0.6	-1.3	0.9
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.3	-0.2	-0.4	0.3	-0.5
Delay discount exponential model param	0.1	0.1	0.2	-0.4	-0.4	0.1	0.3	0.0
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.6	-0.7	0.2	0.6	-0.0
Fecal boli incidents, locomotor time 1	0.5	0.5	1.0	1.0	1.0	-0.3	-0.8	0.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.2	0.3	0.7	-0.5	0.5
Time >=10cm from walls, locomotor time 1	1.2	1.3	1.6	-1.2	-0.9	-1.0	1.2	-1.3
Bouts of movement, locomotor time 1	4.1	4.5	6.1	2.2	2.4	1.4	-2.5	2.0
Total resting periods, locomotor time 1	4.6	5.2	6.6	2.2	2.3	1.9	-2.6	2.4
Rest time, locomotor task time 1	2.6	2.8	4.0	1.7	1.8	1.1	-2.0	1.6
Distance moved, locomotor task time 1	2.4	2.7	3.6	-1.9	-1.9	-0.7	1.9	-1.4
Vertical activity count, locomotor time 1	2.2	2.3	3.8	-1.0	-1.1	-2.0	1.4	-1.9
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.5	0.7	0.6	-0.1	-0.6	0.4
Bouts of movement, locomotor time 2	4.0	4.3	5.0	2.1	2.0	1.7	-2.2	2.2
Total resting periods, locomotor time 2	4.7	5.1	6.0	2.3	2.2	1.9	-2.4	2.4
Rest time, locomotor task time 2	2.0	2.4	4.2	1.0	1.0	2.0	-1.5	1.8
Distance moved, locomotor task time 2	3.8	4.5	5.9	-1.8	-1.8	-2.3	2.2	-2.4
Vertical activity count, locomotor time 2	1.8	2.0	5.0	-0.5	-0.6	-2.2	1.1	-1.7
Weight adjusted by age	1.1	1.2	2.1	1.5	1.4	-0.3	-1.2	0.7
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	1.6	-1.1	-1.0	-1.0	1.3	-1.2
Locomotion in novel chamber	0.5	0.6	1.1	-0.6	-0.4	-1.0	0.7	-1.1
Locomotion in novel chamber post-restriction	0.5	0.6	0.9	0.7	0.9	0.5	-0.9	0.8
Progressive ratio	0.1	0.1	0.2	-0.3	-0.4	0.1	0.3	-0.0
Food seeking constrained by brief footshock	4.6	5.6	11.8	1.2	1.3	3.4	-2.0	3.1
Seeking ratio, punishment vs. effort	1.6	2.0	3.0	0.9	1.1	1.7	-1.4	1.7
Run reversals in cocaine runway, females	3.4	3.4	4.5	-2.1	-2.1	-1.0	2.1	-1.6
Run reversals in cocaine runway, males	1.5	1.5	2.4	1.3	1.5	0.3	-1.5	0.9
Latency to leave start box in cocaine runway	0.5	0.5	0.9	0.9	0.8	0.2	-0.8	0.6
Latency to leave start box in cocaine runway, F	0.9	1.0	1.7	1.3	1.3	-0.1	-1.2	0.7
Latency to leave start box in cocaine runway, M	0.9	0.9	1.3	-0.8	-1.1	-0.6	1.1	-0.9
Cd content in liver	0.2	0.2	0.4	-0.6	-0.6	0.1	0.5	-0.2
Co content in liver	4.5	5.3	7.0	2.1	2.1	2.1	-2.5	2.6
Cu content in liver	0.5	0.6	0.7	0.8	0.8	0.6	-0.9	0.8
Fe content in liver	1.6	1.9	2.6	-1.6	-1.6	-0.6	1.6	-1.2
K content in liver	0.4	0.4	0.6	-0.8	-0.8	0.2	0.7	-0.2
Mg content in liver	0.7	0.8	1.3	-1.1	-1.1	0.3	1.0	-0.3
Mn content in liver	1.6	1.8	2.5	-1.5	-1.5	-0.7	1.6	-1.3
Na content in liver	2.4	2.5	8.2	0.8	0.8	-2.9	-0.1	-1.8
Rb content in liver	0.5	0.7	2.0	-0.5	-0.5	1.4	0.2	0.8
Se content in liver	3.9	4.7	10.4	-1.0	-1.0	-3.2	1.7	-2.9
Sr content in liver	0.5	0.5	0.6	-0.7	-0.7	-0.6	0.8	-0.8
Zn content in liver	1.1	1.2	3.1	1.0	1.0	-1.8	-0.5	-0.8