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Total locomotion distance, NPP test

Total distance of locomotion during novelty place preference test for males and females [meters]

Tags: Behavior · Motivation · Novelty · Locomotion

Project: p50_shelly_flagel_2014

4 loci · 7 genes with independent associations · 20 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	134466988	135864494	2	1	1.29e-07	5.13e-07	3.69e-01	Pde8a
2	chr1	140510980	142727457	16	4	4.67e-17	1.73e-17	NaN	Ctsc Grm5
3	chr8	108585012	109845634	1	1	6.63e-16	5.38e-02	1.00e+00	Klhdc8b
4	chr14	31145547	32538496	1	1	4.31e-08	3.30e-10	1.12e-03	Nmu

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	18.84	1	1	14.3	0	1.00e+00	Klhdc8b
BMI without tail	27.06	1	1	14.3	0	1.00e+00	Klhdc8b
Body weight	20.7	1	1	14.3	0	1.00e+00	Klhdc8b
Heart weight	17.24	1	0	0	0	1.00e+00	Klhdc8b
Left kidney weight	27.97	1	1	14.3	0	1.00e+00	Klhdc8b
Right kidney weight	10.32	1	1	14.3	0	1.00e+00	Klhdc8b
Tail length	8.12	1	0	0	0	1.00e+00	Klhdc8b
Length with tail	9.26	1	1	14.3	0	1.00e+00	Klhdc8b
Liver weight, left	13.45	1	0	0	0	1.00e+00	Klhdc8b
Liver weight, right	7.14	1	0	0	0.99	7.24e-03	Grm5
Retroperitoneal fat weight	6.24	1	0	0	0	1.00e+00	Klhdc8b
Intraocular pressure	11.89	3	0	0	-0.99	6.82e-19	Ctsc Grm5 LOC102554680
Extensor digitorum longus weight	3.34	1	0	0	0	1.00e+00	Nmu
Soleus weight	8.84	1	0	0	0	1.00e+00	Klhdc8b
Tibia length	10.96	1	1	14.3	0	1.00e+00	Klhdc8b
Number of licking bursts	24.53	1	1	14.3	0	1.00e+00	Klhdc8b
Food consumed during 24 hour testing period	9.01	1	0	0	0	1.00e+00	Klhdc8b
Mean time between licks in bursts	8.24	3	0	0	1	2.72e-11	Ctsc Grm5 LOC102554680
Mean num. licks in bursts	11.71	1	0	0	0	1.00e+00	Klhdc8b
Patch foraging indifference point 0 sec	8.18	1	0	0	0	1.00e+00	Klhdc8b
Indifference point function ln k	36.38	1	1	14.3	0	1.00e+00	Klhdc8b
Indifference point function log k	36.38	1	1	14.3	0	1.00e+00	Klhdc8b
Patch foraging total patch changes 0 sec	8.89	1	0	0	0	1.00e+00	Klhdc8b
Patch foraging total patch changes 12 sec	8.65	1	0	0	0	1.00e+00	Pde8a
Patch foraging time to switch 0 sec	9.16	3	0	0	0.99	4.15e-11	Ctsc Grm5 LOC102554680
Patch foraging water rate 0 sec	7.05	1	0	0	0	1.00e+00	Grm5
Patch foraging water rate 12 sec	11.9	4	1	14.3	-0.99	1.89e-17	Ctsc Grm5 LOC102554680 Pde8a
Patch foraging water rate 18 sec	19.44	4	3	42.9	-0.99	2.65e-24	Ctsc Grm5 LOC102554680 Pde8a
Patch foraging water rate 24 sec	7.66	2	0	0	-1	6.01e-04	Ctsc Grm5
Patch foraging water rate 6 sec	8.26	2	0	0	-1	2.92e-06	Ctsc Grm5
Locomotor activity	57.78	1	1	14.3	0	1.00e+00	Klhdc8b
Locomotor testing distance	64.52	1	1	14.3	0	1.00e+00	Klhdc8b
Light reinforcement 1	10.89	4	0	0	1	2.22e-30	Ctsc Grm5 LOC102554680 Pde8a
Light reinforcement 2	17.85	5	3	42.9	1	5.30e-48	Ctsc Grm5 LOC102554680 Pde8a Tyr
Reaction time number correct	18.64	1	1	14.3	0	1.00e+00	Klhdc8b
Reaction time num false alarms	12.62	4	0	0	1	2.24e-29	Ctsc Grm5 LOC102554680 Pde8a
Reaction time num false alarms AUC	10.37	3	0	0	1	7.37e-24	Ctsc Grm5 LOC102554680
Reaction time trials correct on left	18.64	1	1	14.3	0	1.00e+00	Klhdc8b
Reaction time trials on left	19.51	1	1	14.3	0	1.00e+00	Klhdc8b
Reaction time mean AUC	9.44	1	0	0	0	1.00e+00	Klhdc8b
Median of all reaction times	10.54	1	0	0	0	1.00e+00	Klhdc8b
Reaction time omissions	23.75	1	1	14.3	0	1.00e+00	Klhdc8b
Reaction time false alarm rate	13.18	4	1	14.3	1	8.95e-26	Ctsc Grm5 Klhdc8b LOC102554680
Reaction time trials completed	19.51	1	1	14.3	0	1.00e+00	Klhdc8b
Reaction time trials AUC	20.65	1	1	14.3	0	1.00e+00	Klhdc8b
Conditioned locomotion	28.4	1	1	14.3	0	1.00e+00	Klhdc8b
Cocaine response after cond. not corrected	16.6	1	0	0	0	1.00e+00	Klhdc8b
Cocaine response before conditioning	38.66	1	1	14.3	0	1.00e+00	Klhdc8b
Pavlov. Cond. magazine entry number	30	1	1	14.3	0	1.00e+00	Klhdc8b
Conditioned reinforcement - inactives	16.77	1	0	0	0	1.00e+00	Klhdc8b
Intermitt. access day 1 inactive lever presses	13.69	1	0	0	0	1.00e+00	Klhdc8b
Intermitt. access day 15 inactive lever presses	30.78	1	1	14.3	0	1.00e+00	Klhdc8b
Intermittent access day 15 total infusions	14.21	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access terminal intake (last 3 days)	13.56	3	0	0	0.22	7.79e-01	Ctsc Klhdc8b LOC102554680
Intermittent access total infusions	15.45	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access day 1 locomotion	11.5	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access standard deviation	16.8	1	0	0	0	1.00e+00	Klhdc8b
Cocaine induced anxiety	13.65	1	0	0	0	1.00e+00	Klhdc8b
Lifetime Intake	9.4	3	0	0	0.44	5.64e-01	Ctsc Klhdc8b LOC102554680
Progressive ratio test 1 inactive lever presses	16.55	1	0	0	0	1.00e+00	Klhdc8b
Progressive ratio test 2 inactive lever presses	10.83	1	0	0	0	1.00e+00	Klhdc8b
Total sessions with >9 infusions	16	1	0	0	0	1.00e+00	Klhdc8b
Short access day 1 total inactive lever presses	13.04	1	0	0	0	1.00e+00	Klhdc8b
Short access day 10 total inactive lever presses	101.65	1	1	14.3	0	1.00e+00	Klhdc8b
Short access day 1 total infusions	10.41	3	0	0	0.99	1.28e-18	Ctsc Grm5 Tyr
Short access day 10 total infusions	13.17	1	0	0	0	1.00e+00	Klhdc8b
Short access day 1 locomotion	11.78	1	0	0	0	1.00e+00	Klhdc8b
One hour access (0.3 mA shock)	13.43	1	0	0	0	1.00e+00	Klhdc8b
Locomotion velocity, session 1	16.27	3	0	0	-1	4.30e-28	Ctsc Grm5 LOC102554680
Locomotion distance, session 1	23.98	1	1	14.3	0	1.00e+00	Klhdc8b
Locomotion velocity, session 2	10	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 2	33.15	1	1	14.3	0	1.00e+00	Klhdc8b
Locomotion velocity, session 3	17.14	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 3	11.4	3	0	0	-0.66	1.55e-01	Ctsc Grm5 Klhdc8b
Stereotopy head waving bouts, day 3	9.64	2	0	0	1	3.51e-18	Ctsc Grm5
Locomotion velocity, session 8	9.22	2	0	0	0	1.00e+00	Ctsc Klhdc8b
Locomotion distance, session 8	52.78	1	1	14.3	0	1.00e+00	Klhdc8b
Degree of sensitization distance	24.75	1	0	0	0	1.00e+00	Klhdc8b
Condit. Reinf. active minus inactive responses	35.59	1	1	14.3	0	1.00e+00	Klhdc8b
Condit. Reinf. active-inactive response ratio	25.6	1	1	14.3	0	1.00e+00	Klhdc8b
Condit. Reinf. active responses	18.23	1	0	0	0	1.00e+00	Klhdc8b
Incentive salience index mean	26.23	1	1	14.3	0	1.00e+00	Klhdc8b
Condit. Reinf. lever presses	10.81	1	0	0	0	1.00e+00	Klhdc8b
Time in familiar zone, hab. session 1	63.49	1	1	14.3	0	1.00e+00	Klhdc8b
Time in novel zone, hab. session 1	13.1	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 1	11.89	3	1	14.3	-0.51	1.97e-01	Ctsc Grm5 Klhdc8b
Total locomotion distance, hab. session 1	22.96	7	4	57.1	0.99	2.98e-41	Ctsc Grm5 Klhdc8b LOC102554680 Nmu Pde8a Tyr
Locomotion velocity, hab. session 1	23.93	7	4	57.1	1	7.29e-43	Ctsc Grm5 Klhdc8b LOC102554680 Nmu Pde8a Tyr
Time in familiar zone, hab. session 2	27.1	1	1	14.3	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 2	69.58	1	1	14.3	0	1.00e+00	Klhdc8b
Total locomotion distance, hab. session 2	28.22	7	3	42.9	1	1.34e-47	Ctsc Grm5 Klhdc8b LOC102554680 Nmu Pde8a Tyr
Locomotion velocity, hab. session 2	26.38	7	4	57.1	1	1.33e-48	Ctsc Grm5 Klhdc8b LOC102554680 Nmu Pde8a Tyr
Novel to familiar place preference ratio	22.33	1	0	0	0	1.00e+00	Klhdc8b
Novelty place preference	20.99	1	0	0	0	1.00e+00	Klhdc8b
Time in novel zone, NPP test	17.06	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, NPP test	106.24	1	1	14.3	0	1.00e+00	Klhdc8b
Locomotion velocity, NPP test	33.07	7	7	100	1	2.99e-73	Ctsc Grm5 Klhdc8b LOC102554680 Nmu Pde8a Tyr
Pavlov. Cond. change in total contacts	69.48	1	1	14.3	0	1.00e+00	Klhdc8b
Pavlov. Cond. index score	14.07	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. latency score	8.82	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. magazine entry number	12.23	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. lever-magazine prob. diff.	14.82	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. response bias	10.49	1	0	0	0	1.00e+00	Klhdc8b
Bone: maximum force	7.19	1	0	0	0	1.00e+00	Klhdc8b
Bone: minimum diameter	6.14	1	0	0	0	1.00e+00	Pde8a
Bone: stiffness	13.41	1	0	0	0	1.00e+00	Klhdc8b
Delta time in closed arm before/after self-admin	12.84	1	0	0	0	1.00e+00	Klhdc8b
Sum of active levers in priming session hrs 5-6	11.05	2	0	0	1	3.59e-03	Ctsc LOC102554680
Time to tail flick, vehicle, after self-admin	37.57	1	1	14.3	0	1.00e+00	Klhdc8b
Delta time to tail flick, vehicle, before/after SA	14.47	1	0	0	0	1.00e+00	Klhdc8b
Total heroin consumption	18.89	1	0	0	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 0s delay	28.7	1	1	14.3	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 16s delay	13.12	1	0	0	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 4s delay	41.82	1	1	14.3	0	1.00e+00	Klhdc8b
Fecal boli incidents, locomotor time 1	16.98	1	0	0	0	1.00e+00	Klhdc8b
Rest time, locomotor task time 1	22.55	1	0	0	0	1.00e+00	Klhdc8b
Distance moved, locomotor task time 1	31.01	1	1	14.3	0	1.00e+00	Klhdc8b
Vertical activity count, locomotor time 1	49.01	1	1	14.3	0	1.00e+00	Klhdc8b
Bouts of movement, locomotor time 2	19.85	1	0	0	0	1.00e+00	Klhdc8b
Total resting periods, locomotor time 2	20.22	1	0	0	0	1.00e+00	Klhdc8b
Rest time, locomotor task time 2	25.34	1	1	14.3	0	1.00e+00	Klhdc8b
Distance moved, locomotor task time 2	42.39	1	1	14.3	0	1.00e+00	Klhdc8b
Vertical activity count, locomotor time 2	54.92	1	1	14.3	0	1.00e+00	Klhdc8b
Weight adjusted by age	30.32	1	1	14.3	0	1.00e+00	Klhdc8b
Seeking ratio, delayed vs. immediate footshock	10	1	0	0	0	1.00e+00	Pde8a
Food seeking constrained by brief footshock	12.71	1	0	0	0	1.00e+00	Klhdc8b
Latency to leave start box in cocaine runway	12.87	1	0	0	1	6.70e-05	Grm5
Cd content in liver	20.17	1	0	0	0	1.00e+00	Klhdc8b
Fe content in liver	40.39	1	1	14.3	0	1.00e+00	Klhdc8b
K content in liver	12.22	1	0	0	0	1.00e+00	Klhdc8b
Mg content in liver	15.79	1	0	0	0	1.00e+00	Klhdc8b
Na content in liver	12.23	3	0	0	-0.99	5.78e-09	Ctsc Klhdc8b LOC102554680
Rb content in liver	51.88	1	1	14.3	0	1.00e+00	Klhdc8b
Sr content in liver	22.41	1	0	0	0	1.00e+00	Klhdc8b
Zn content in liver	9.95	1	0	0	0	1.00e+00	Klhdc8b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	2	0.1	1.43
Adipose	alternative TSS	0	0	1.4
Adipose	gene expression	1	0	1.38
Adipose	isoform ratio	2	0	1.39
Adipose	intron excision ratio	2	0.1	1.44
Adipose	mRNA stability	0	0	1.34
BLA	alternative polyA	0	0	1.3
BLA	alternative TSS	0	0	1.36
BLA	gene expression	3	0	1.38
BLA	isoform ratio	3	0.1	1.36
BLA	intron excision ratio	0	0	1.39
BLA	mRNA stability	0	0	1.32
Brain	alternative polyA	2	0.1	1.43
Brain	alternative TSS	0	0	1.38
Brain	gene expression	2	0	1.38
Brain	isoform ratio	3	0.1	1.36
Brain	intron excision ratio	0	0	1.36
Brain	mRNA stability	1	0	1.35
Eye	alternative polyA	0	0	1.57
Eye	alternative TSS	0	0	1.38
Eye	gene expression	1	0.1	1.52
Eye	isoform ratio	0	0	1.36
Eye	intron excision ratio	0	0	1.61
Eye	mRNA stability	0	0	1.49
IL	alternative polyA	0	0	1.34
IL	alternative TSS	0	0	1.29
IL	gene expression	1	0	1.45
IL	isoform ratio	0	0	1.37
IL	intron excision ratio	0	0	1.37
IL	mRNA stability	0	0	1.34
LHb	alternative polyA	0	0	1.36
LHb	alternative TSS	0	0	1.25
LHb	gene expression	1	0	1.4
LHb	isoform ratio	0	0	1.31
LHb	intron excision ratio	0	0	1.62
LHb	mRNA stability	0	0	1.29
Liver	alternative polyA	0	0	1.4
Liver	alternative TSS	2	0.1	1.39
Liver	gene expression	2	0	1.37
Liver	isoform ratio	0	0	1.36
Liver	intron excision ratio	0	0	1.31
Liver	mRNA stability	0	0	1.36
NAcc	alternative polyA	0	0	1.39
NAcc	alternative TSS	0	0	1.45
NAcc	gene expression	2	0	1.38
NAcc	isoform ratio	4	0.1	1.37
NAcc	intron excision ratio	0	0	1.39
NAcc	mRNA stability	0	0	1.34
OFC	alternative polyA	0	0	1.34
OFC	alternative TSS	0	0	1.51
OFC	gene expression	1	0	1.42
OFC	isoform ratio	0	0	1.37
OFC	intron excision ratio	0	0	1.44
OFC	mRNA stability	0	0	1.37
PL	alternative polyA	1	0	1.32
PL	alternative TSS	0	0	1.36
PL	gene expression	2	0	1.36
PL	isoform ratio	4	0.1	1.34
PL	intron excision ratio	0	0	1.34
PL	mRNA stability	0	0	1.34
pVTA	alternative polyA	0	0	1.32
pVTA	alternative TSS	0	0	1.38
pVTA	gene expression	1	0	1.4
pVTA	isoform ratio	0	0	1.32
pVTA	intron excision ratio	0	0	1.29
pVTA	mRNA stability	0	0	1.29
RMTg	alternative polyA	0	0	1.22
RMTg	alternative TSS	0	0	1.21
RMTg	gene expression	0	0	1.35
RMTg	isoform ratio	0	0	1.26
RMTg	intron excision ratio	0	0	1.3
RMTg	mRNA stability	0	0	1.33