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Total locomotion distance, NPP test

Total distance of locomotion during novelty place preference test for males and females [meters]

Tags: Behavior · Motivation · Novelty · Locomotion

Project: p50_shelly_flagel_2014

28 significantly associated models · 5 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 140510980 142727457 3 1 4.7e-17 1.7e-17 0.81 100 Ctsc
2 7 16845355 16970279 1 1 3.0e-83 NaN NA NA NA
3 14 31927677 33323902 1 1 7.4e-10 1.5e-10 1.00 100 Kit

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 106.7 1 1 33 0.00 1.0e+00 NA
Body weight 7.7 1 1 33 0.00 1.0e+00 NA
Epididymis fat weight 87.6 1 1 33 0.00 1.0e+00 NA
Glucose 6.6 1 0 0 0.00 1.0e+00 NA
Heart weight 11.4 1 0 0 0.00 1.0e+00 NA
Left kidney weight 37.5 1 1 33 0.00 1.0e+00 NA
Right kidney weight 41.9 1 1 33 0.00 1.0e+00 NA
Tail length 58.1 1 1 33 0.00 1.0e+00 NA
Length with tail 4.0 1 0 0 0.00 1.0e+00 NA
Length without tail 71.1 1 1 33 0.00 1.0e+00 NA
Liver weight, left 23.6 1 1 33 0.00 1.0e+00 NA
Liver weight, right 9.6 1 0 0 0.00 1.0e+00 NA
Parametrial fat weight 26.4 1 1 33 0.00 1.0e+00 NA
Retroperitoneal fat weight 4.2 1 0 0 0.00 1.0e+00 NA
Intraocular pressure 13.1 3 1 33 -0.96 1.3e-07 Grm5 Ctsc NA
Extensor digitorum longus weight 25.8 1 1 33 0.00 1.0e+00 NA
Soleus weight 13.7 1 1 33 0.00 1.0e+00 NA
Tibialis anterior weight 59.9 1 1 33 0.00 1.0e+00 NA
Tibia length 7.4 1 0 0 0.00 1.0e+00 NA
Number of licking bursts 155.0 1 1 33 0.00 1.0e+00 NA
Food consumed during 24 hour testing period 17.5 1 0 0 0.00 1.0e+00 NA
Times rat made contact with spout 75.1 1 1 33 0.00 1.0e+00 NA
Mean time between licks in bursts 13.7 3 1 33 0.08 7.6e-01 Grm5 Ctsc NA
Mean num. licks in bursts 164.2 1 1 33 0.00 1.0e+00 NA
Std. dev. time between licks in bursts 177.7 1 1 33 0.00 1.0e+00 NA
Indifference point 0 sec 18.7 1 1 33 0.00 1.0e+00 NA
Indifference point AUC 42.1 1 1 33 0.00 1.0e+00 NA
Delay discounting total patch changes 0 sec 17.7 1 1 33 0.00 1.0e+00 NA
Delay discounting total patch changes 12 sec 102.7 1 1 33 0.00 1.0e+00 NA
Delay discounting total patch changes 18 sec 175.3 1 1 33 0.00 1.0e+00 NA
Delay discounting total patch changes 24 sec 28.3 1 1 33 0.00 1.0e+00 NA
Delay discounting total patch changes 6 sec 98.5 1 1 33 0.00 1.0e+00 NA
Delay discounting time to switch 0 sec 9.4 2 0 0 0.98 5.1e-06 Grm5 Ctsc
Delay discounting water rate 0 sec 9.1 3 0 0 0.08 9.2e-01 Grm5 Ctsc NA
Delay discounting water rate 12 sec 15.6 3 3 100 -0.97 3.9e-07 Grm5 Ctsc NA
Delay discounting water rate 18 sec 18.0 3 2 67 -0.74 2.1e-04 Grm5 Ctsc NA
Delay discounting water rate 24 sec 23.6 3 1 33 0.42 3.4e-01 Grm5 Ctsc NA
Delay discounting water rate 6 sec 15.5 3 1 33 0.08 8.3e-01 Grm5 Ctsc NA
Locomotor activity 6.7 1 0 0 0.00 1.0e+00 Kit
Locomotor testing distance 9.9 2 0 0 0.00 1.0e+00 Kit NA
Locomotor testing rearing 16.8 1 1 33 0.00 1.0e+00 NA
Light reinforcement 1 13.6 3 1 33 1.00 4.8e-23 Grm5 Ctsc NA
Light reinforcement 2 18.1 3 2 67 1.00 6.2e-31 Tyr Grm5 Ctsc
Reaction time number correct 9.4 1 0 0 0.00 1.0e+00 NA
Reaction time num false alarms 16.2 3 1 33 0.99 2.5e-18 Grm5 Ctsc NA
Reaction time num false alarms AUC 21.3 3 1 33 0.99 4.6e-10 Grm5 Ctsc NA
Reaction time trials correct on left 9.4 1 0 0 0.00 1.0e+00 NA
Reaction time trials on left 10.3 1 0 0 0.00 1.0e+00 NA
Reaction time mean 41.3 1 1 33 0.00 1.0e+00 NA
Reaction time mean AUC 58.0 1 1 33 0.00 1.0e+00 NA
Median of all reaction times 51.2 1 1 33 0.00 1.0e+00 NA
Reaction time false alarm rate 16.7 3 1 33 0.99 2.8e-17 Grm5 Ctsc NA
Reaction time premature initiation rate 32.1 1 1 33 0.00 1.0e+00 NA
Reaction time premature initiations 34.3 1 1 33 0.00 1.0e+00 NA
Std. dev. reaction times 17.4 1 1 33 0.00 1.0e+00 NA
Reaction time trials completed 10.3 1 0 0 0.00 1.0e+00 NA
Reaction time trials AUC 15.6 1 0 0 0.00 1.0e+00 NA
Social responses 74.3 1 1 33 0.00 1.0e+00 NA
Social time 7.8 1 0 0 0.00 1.0e+00 NA
Cocaine response after cond. corrected 78.0 1 1 33 0.00 1.0e+00 NA
Cocaine response after cond. not corrected 102.3 1 1 33 0.00 1.0e+00 NA
Cocaine response before conditioning 28.6 1 1 33 0.00 1.0e+00 NA
Saline control response 30.3 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active minus inactive responses 29.4 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 40.7 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active responses 11.1 1 0 0 0.00 1.0e+00 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. lever latency 36.3 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 104.9 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 130.1 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. index score 62.2 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. latency score 67.1 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 29.4 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 150.0 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. intertrial magazine entries 63.9 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 55.1 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. response bias 30.8 1 1 33 0.00 1.0e+00 NA
Conditioned reinforcement - actives 18.5 1 0 0 0.00 1.0e+00 NA
Conditioned locomotion 9.9 1 0 0 0.00 1.0e+00 NA
Intermittent access intake day 1-15 change 61.5 1 1 33 0.00 1.0e+00 NA
Intermittent access intake escalation 82.5 1 1 33 0.00 1.0e+00 NA
Intermittent access intake escalation 2 42.5 1 1 33 0.00 1.0e+00 NA
Intermitt. access day 1 inactive lever presses 30.6 1 1 33 0.00 1.0e+00 NA
Intermittent access day 1 total infusions 32.7 1 1 33 0.00 1.0e+00 NA
Intermittent access terminal intake (last 3 days) 10.0 2 0 0 0.00 1.0e+00 Tyr Ctsc
Intermittent access day 1 locomotion 18.4 1 1 33 0.00 1.0e+00 NA
Post-drug Anxiety 20.6 1 0 0 0.00 1.0e+00 NA
Lifetime Intake 9.4 2 0 0 0.00 1.0e+00 Tyr Ctsc
Progressive ratio test 1 active lever presses 11.8 1 0 0 0.00 1.0e+00 NA
Progressive ratio test 1 breakpoint 10.4 1 0 0 0.00 1.0e+00 NA
Progressive ratio test 1 inactive lever presses 10.8 1 0 0 0.00 1.0e+00 NA
Progressive ratio test 2 active lever presses 12.2 1 0 0 0.00 1.0e+00 NA
Progressive ratio test 2 breakpoint 38.7 1 1 33 0.00 1.0e+00 NA
Total sessions with >9 infusions 9.5 1 0 0 0.00 1.0e+00 Ctsc
Short access day 10 total inactive lever presses 12.2 1 0 0 0.00 1.0e+00 NA
Short access day 1 total infusions 10.4 3 0 0 0.99 2.7e-14 Tyr Grm5 Ctsc
Short access day 10 total infusions 24.0 1 1 33 0.00 1.0e+00 NA
Short access day 1 locomotion 17.2 1 0 0 0.00 1.0e+00 NA
Compulsive drug intake 28.2 1 1 33 0.00 1.0e+00 NA
One hour access (0.3 mA shock) 10.4 1 0 0 0.00 1.0e+00 NA
Context. condit. distance diff. score 149.8 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, session 1 24.1 3 1 33 -0.21 3.6e-01 Grm5 Ctsc NA
Locomotion distance, session 1 374.7 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, session 2 45.4 3 1 33 0.85 1.5e-01 Grm5 Ctsc NA
Locomotion distance, session 2 776.0 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, session 3 116.1 1 1 33 0.00 1.0e+00 NA
Locomotion distance, session 3 34.5 3 1 33 0.42 4.1e-01 Grm5 Ctsc NA
Stereotopy head waving bouts, day 3 9.8 3 0 0 0.93 7.3e-04 Grm5 Ctsc NA
Stereotopy head waving duration, day 3 21.0 2 1 33 0.00 1.0e+00 Kit NA
Locomotion velocity, session 7 66.3 1 1 33 0.00 1.0e+00 NA
Locomotion distance, session 7 21.3 1 1 33 0.00 1.0e+00 NA
Stereotopy head waving bouts, day 7 32.5 2 1 33 0.00 1.0e+00 Kit NA
Stereotopy head waving duration, day 7 63.4 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, session 8 8.4 2 0 0 0.00 1.0e+00 Grm5 Ctsc
Locomotion distance, session 8 102.8 1 1 33 0.00 1.0e+00 NA
Degree of sensitization distance 140.6 1 1 33 0.00 1.0e+00 NA
Degree of sensitization stereotypy 37.5 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 65.1 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active responses 20.0 1 0 0 0.00 1.0e+00 NA
Condit. Reinf. inactive responses 17.2 1 0 0 0.00 1.0e+00 NA
Incentive salience index mean 15.6 1 0 0 0.00 1.0e+00 NA
Condit. Reinf. lever presses 35.1 1 1 33 0.00 1.0e+00 NA
Time in familiar zone, hab. session 1 16.4 1 0 0 0.00 1.0e+00 NA
Time in novel zone, hab. session 1 17.4 1 0 0 0.00 1.0e+00 NA
Total zone transitions, hab. session 1 143.8 2 1 33 0.89 1.7e-02 Ctsc NA
Total locomotion distance, hab. session 1 33.5 5 4 133 0.99 9.2e-26 Kit Tyr Grm5 Ctsc NA
Locomotion velocity, hab. session 1 37.7 5 4 133 0.99 1.7e-22 Kit Tyr Grm5 Ctsc NA
Time in familiar zone, hab. session 2 48.9 1 1 33 0.00 1.0e+00 NA
Time in novel zone, hab. session 2 34.1 1 1 33 0.00 1.0e+00 NA
Total zone transitions, hab. session 2 256.1 1 1 33 0.00 1.0e+00 NA
Total locomotion distance, hab. session 2 36.1 5 4 133 1.00 1.4e-35 Kit Tyr Grm5 Ctsc NA
Locomotion velocity, hab. session 2 34.6 5 4 133 1.00 1.2e-35 Kit Tyr Grm5 Ctsc NA
Total zone transitions, NPP test 228.8 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, NPP test 43.9 5 5 167 1.00 6.5e-35 Kit Tyr Grm5 Ctsc NA
Pavlov. Cond. lever latency 8.6 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 56.4 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 40.1 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. index score 51.9 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. latency score 16.6 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 13.3 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 34.9 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 50.5 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. response bias 52.4 1 1 33 0.00 1.0e+00 NA
Bone: apparent density 18.6 1 1 33 0.00 1.0e+00 NA
Bone surface 28.9 1 1 33 0.00 1.0e+00 NA
Bone volume 32.3 1 1 33 0.00 1.0e+00 NA
Bone: connectivity density 8.5 1 0 0 0.00 1.0e+00 NA
Bone: cortical porosity 109.3 1 1 33 0.00 1.0e+00 NA
Bone: cortical porosity 91.2 1 1 33 0.00 1.0e+00 NA
Bone: cortical thickness 8.8 1 0 0 0.00 1.0e+00 NA
Bone: cortical thickness 17.9 1 0 0 0.00 1.0e+00 NA
Bone: elastic displacement 28.2 1 1 33 0.00 1.0e+00 NA
Bone: endosteal estimation 12.7 1 1 33 0.00 1.0e+00 NA
Bone: final force 39.5 1 1 33 0.00 1.0e+00 NA
Bone: final moment 31.9 1 1 33 0.00 1.0e+00 NA
Bone: marrow area 10.6 1 1 33 0.00 1.0e+00 NA
Bone: maximum force 42.0 1 1 33 0.00 1.0e+00 NA
Bone: maximum moment 29.5 1 1 33 0.00 1.0e+00 NA
Bone: minimum diameter 57.3 1 1 33 0.00 1.0e+00 NA
Bone: periosteal estimation 7.8 1 0 0 0.00 1.0e+00 NA
Bone: periosteal perimeter 8.8 1 0 0 0.00 1.0e+00 NA
Bone: post-yield work 82.8 1 1 33 0.00 1.0e+00 NA
Bone: stiffness 90.4 1 1 33 0.00 1.0e+00 NA
Bone: tissue strength 81.0 1 1 33 0.00 1.0e+00 NA
Bone: trabecular number 39.4 1 1 33 0.00 1.0e+00 NA
Bone: trabecular thickness 13.8 1 0 0 0.00 1.0e+00 NA
Bone: trabecular tissue density 43.1 1 1 33 0.00 1.0e+00 NA
Distance traveled before self-admin 12.6 1 0 0 0.00 1.0e+00 NA
Delta time in open arm before/after self-admin 40.2 1 1 33 0.00 1.0e+00 NA
Extinction: sum of active levers before priming 12.2 1 0 0 0.00 1.0e+00 NA
Delta distance traveled before/after self-admin 11.3 1 0 0 0.00 1.0e+00 NA
Time in closed arm before self-admin 50.0 1 1 33 0.00 1.0e+00 NA
Time in closed arm after self-admin 25.8 1 1 33 0.00 1.0e+00 NA
Time in open arm after self-admin 31.3 1 1 33 0.00 1.0e+00 NA
Sum of active levers in priming session hrs 5-6 10.6 3 0 0 0.99 2.6e-11 Tyr Grm5 Ctsc
Delta time to tail flick, test, before/after SA 20.0 1 0 0 0.00 1.0e+00 NA
Fecal boli incidents, locomotor time 1 11.8 1 0 0 0.00 1.0e+00 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0 0.00 1.0e+00 NA
Time >=10cm from walls, locomotor time 2 19.4 1 1 33 0.00 1.0e+00 NA
Rest time, locomotor task time 2 8.8 1 0 0 0.00 1.0e+00 NA
Distance moved, locomotor task time 2 13.1 1 0 0 0.00 1.0e+00 NA
Vertical activity count, locomotor time 2 9.4 3 0 0 0.53 4.7e-01 Kit Grm5 Ctsc
Weight adjusted by age 25.0 1 1 33 0.00 1.0e+00 NA
Locomotion in novel chamber 10.2 1 0 0 0.00 1.0e+00 NA
Run reversals in cocaine runway, males 25.4 1 1 33 0.00 1.0e+00 NA
Latency to leave start box in cocaine runway 14.6 3 0 0 0.89 4.5e-02 Grm5 Ctsc NA
Latency to leave start box in cocaine runway, F 9.6 1 0 0 0.00 1.0e+00 Ctsc
Cd content in liver 140.5 1 1 33 0.00 1.0e+00 NA
Co content in liver 83.2 1 1 33 0.00 1.0e+00 NA
Fe content in liver 10.3 1 0 0 0.00 1.0e+00 NA
K content in liver 62.6 1 1 33 0.00 1.0e+00 NA
Mn content in liver 130.2 1 1 33 0.00 1.0e+00 NA
Na content in liver 11.1 2 0 0 -0.98 4.5e-08 Tyr Ctsc
Rb content in liver 31.4 1 1 33 0.00 1.0e+00 NA
Se content in liver 47.0 1 1 33 0.00 1.0e+00 NA
Zn content in liver 46.0 1 1 33 0.00 1.0e+00 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 2 0.094 1.5
Adipose alternative TSS 0 0.000 1.4
Adipose gene expression 0 0.000 1.4
Adipose isoform ratio 2 0.071 1.5
Adipose intron excision ratio 2 0.069 1.4
Adipose mRNA stability 1 0.029 1.4
BLA alternative polyA 2 0.167 1.5
BLA alternative TSS 0 0.000 1.5
BLA gene expression 2 0.033 1.4
BLA isoform ratio 0 0.000 1.4
BLA intron excision ratio 0 0.000 1.3
BLA mRNA stability 1 0.049 1.4
Brain alternative polyA 0 0.000 1.5
Brain alternative TSS 0 0.000 1.4
Brain gene expression 2 0.022 1.4
Brain isoform ratio 1 0.032 1.4
Brain intron excision ratio 0 0.000 1.3
Brain mRNA stability 0 0.000 1.4
Eye alternative polyA 0 0.000 1.6
Eye alternative TSS 0 0.000 1.5
Eye gene expression 1 0.089 1.5
Eye isoform ratio 0 0.000 1.4
Eye intron excision ratio 0 0.000 1.5
Eye mRNA stability 0 0.000 1.6
IL alternative polyA 0 0.000 1.5
IL alternative TSS 0 0.000 1.4
IL gene expression 1 0.027 1.4
IL isoform ratio 0 0.000 1.4
IL intron excision ratio 0 0.000 1.3
IL mRNA stability 0 0.000 1.4
LHb alternative polyA 0 0.000 1.4
LHb alternative TSS 0 0.000 1.6
LHb gene expression 1 0.031 1.4
LHb isoform ratio 0 0.000 1.4
LHb intron excision ratio 0 0.000 1.5
LHb mRNA stability 1 0.097 1.4
Liver alternative polyA 0 0.000 1.4
Liver alternative TSS 0 0.000 1.4
Liver gene expression 0 0.000 1.3
Liver isoform ratio 0 0.000 1.4
Liver intron excision ratio 0 0.000 1.3
Liver mRNA stability 1 0.041 1.4
NAcc alternative polyA 0 0.000 1.5
NAcc alternative TSS 0 0.000 1.5
NAcc gene expression 1 0.016 1.4
NAcc isoform ratio 0 0.000 1.4
NAcc intron excision ratio 0 0.000 1.4
NAcc mRNA stability 1 0.044 1.4
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.3
OFC gene expression 1 0.027 1.4
OFC isoform ratio 0 0.000 1.3
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 1 0.093 1.4
PL alternative polyA 0 0.000 1.5
PL alternative TSS 0 0.000 1.6
PL gene expression 1 0.014 1.4
PL isoform ratio 2 0.090 1.6
PL intron excision ratio 0 0.000 1.3
PL mRNA stability 1 0.034 1.4

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.