Best TWAS P=3.38e-09 · Best GWAS P=7.06e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Elavl1 | alternative TSS | XM_039089620.1 | 0.24 | 2417 | 0.11 | 7.3e-12 | -5.43 | 5.66e-08 | 0.43 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089620.1 | 0.17 | 2417 | 0.07 | 1.7e-08 | -5.4 | 6.64e-08 | 0.43 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089621.1 | 0.15 | 2417 | 0.07 | 7.6e-08 | 5.39 | 6.89e-08 | 0.43 | FALSE |
| Adipose | LOC120095871 | alternative TSS | XM_039089913.1 | 0.05 | 15 | 0.03 | 8.1e-04 | 5.35 | 8.89e-08 | 0.39 | FALSE |
| Adipose | LOC120095871 | alternative TSS | XM_039089914.1 | 0.05 | 18 | 0.02 | 1.1e-03 | -5.36 | 8.19e-08 | 0.38 | FALSE |
| Adipose | Map2k7 | gene expression | Map2k7 | 0.06 | 2244 | 0.03 | 2.3e-04 | -5.49 | 3.91e-08 | 0.47 | FALSE |
| Adipose | Trappc5 | gene expression | Trappc5 | 0.08 | 62 | 0.04 | 9.4e-06 | 5.91 | 3.38e-09 | 0.65 | TRUE |
| Adipose | Elavl1 | isoform ratio | NM_001108848.1 | 0.14 | 2417 | 0.04 | 1.9e-05 | 5.3 | 1.15e-07 | 0.32 | FALSE |
| Adipose | Elavl1 | isoform ratio | XM_039089620.1 | 0.26 | 219 | 0.12 | 4.8e-13 | 5.49 | 3.96e-08 | 0.43 | FALSE |
| Adipose | Elavl1 | mRNA stability | Elavl1 | 0.27 | 130 | 0.12 | 6.3e-13 | -5.58 | 2.47e-08 | 0.43 | FALSE |
| BLA | Snapc2 | gene expression | Snapc2 | 0.16 | 15 | 0.06 | 3.7e-04 | 5.48 | 4.24e-08 | 0.45 | FALSE |
| BLA | Snapc2 | isoform ratio | XM_039089313.1 | 0.15 | 2285 | 0.04 | 5.8e-03 | 5.56 | 2.67e-08 | 0.49 | FALSE |
| Brain | Elavl1 | gene expression | Elavl1 | 0.1 | 2419 | 0.05 | 2.7e-05 | -5.52 | 3.47e-08 | 0.44 | FALSE |
| Brain | Elavl1 | mRNA stability | Elavl1 | 0.14 | 12 | 0.07 | 5.1e-07 | 5.59 | 2.24e-08 | 0.52 | FALSE |
| Eye | LOC120095871 | intron excision ratio | chr12_3871255_3873703 | 0.33 | 132 | 0.09 | 1.8e-02 | -5.24 | 1.62e-07 | 0.34 | FALSE |
| IL | LOC102552452 | gene expression | LOC102552452 | 0.51 | 100 | 0.32 | 2.3e-08 | -5.49 | 3.93e-08 | 0.6 | TRUE |
| Liver | Stxbp2 | alternative polyA | XM_006248783.4 | 0.07 | 39 | 0.06 | 2.8e-07 | 5.23 | 1.69e-07 | 0 | FALSE |
| Liver | Cd209a | gene expression | Cd209a | 0.2 | 234 | 0.05 | 4.9e-06 | 5.46 | 4.76e-08 | 0.54 | FALSE |
| Liver | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.2 | 76 | 0.1 | 4.0e-11 | 5.21 | 1.89e-07 | 0.56 | FALSE |
| Liver | Elavl1 | mRNA stability | Elavl1 | 0.08 | 2417 | 0.04 | 4.1e-05 | 5.5 | 3.79e-08 | 0.43 | FALSE |
| Liver | Pet100 | mRNA stability | Pet100 | 0.5 | 1831 | 0.31 | 3.8e-35 | 5.49 | 4.00e-08 | 0.76 | FALSE |
| NAcc | Snapc2 | alternative TSS | NM_001415804.1 | 0.09 | 2285 | 0.06 | 5.2e-07 | -5.44 | 5.28e-08 | 0.56 | FALSE |
| NAcc | Snapc2 | alternative TSS | XM_039089313.1 | 0.07 | 2285 | 0.03 | 6.7e-04 | 5.43 | 5.63e-08 | 0.48 | FALSE |
| NAcc | Snapc2 | alternative TSS | NM_001415804.1 | 0.08 | 2285 | 0.04 | 6.5e-06 | -5.46 | 4.69e-08 | 0.57 | FALSE |
| NAcc | Snapc2 | alternative TSS | XM_039089313.1 | 0.07 | 16 | 0.03 | 2.4e-04 | -5.37 | 8.08e-08 | 0.49 | FALSE |
| NAcc | Cers4 | gene expression | Cers4 | 0.39 | 56 | 0.41 | 1.3e-51 | -5.58 | 2.42e-08 | 0.57 | FALSE |
| NAcc | Stxbp2 | gene expression | Stxbp2 | 0.1 | 1833 | 0.05 | 7.4e-07 | -5.22 | 1.80e-07 | 0.8 | FALSE |
| NAcc | Zfp958 | gene expression | Zfp958 | 0.09 | 29 | 0.09 | 2.6e-10 | 5.51 | 3.51e-08 | 0.46 | TRUE |
| NAcc | Snapc2 | isoform ratio | NM_001415804.1 | 0.07 | 6 | 0.04 | 2.4e-05 | 5.45 | 5.05e-08 | 0.62 | FALSE |
| OFC | Snapc2 | gene expression | Snapc2 | 0.56 | 241 | 0.13 | 5.8e-04 | 5.71 | 1.14e-08 | 0.5 | FALSE |
| PL | Snapc2 | gene expression | Snapc2 | 0.39 | 13 | 0.2 | 5.5e-22 | -5.26 | 1.43e-07 | 0.66 | FALSE |
| PL | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.29 | 1836 | 0.16 | 7.5e-17 | -5.28 | 1.28e-07 | 0.81 | FALSE |
| PL | Zfp958 | mRNA stability | Zfp958 | 0.03 | 6 | 0.01 | 8.9e-03 | 5.29 | 1.25e-07 | 0.45 | FALSE |
| pVTA | Snapc2 | alternative TSS | XM_039089313.1 | 0.39 | 20 | 0.07 | 5.5e-04 | 5.37 | 8.04e-08 | 0.62 | FALSE |
| pVTA | Snapc2 | alternative TSS | NM_001415804.1 | 0.21 | 11 | 0.07 | 6.9e-04 | 5.22 | 1.82e-07 | 0.5 | TRUE |
| pVTA | Snapc2 | alternative TSS | XM_039089313.1 | 0.32 | 42 | 0.04 | 1.0e-02 | -5.53 | 3.21e-08 | 0.54 | FALSE |
| pVTA | Cers4 | gene expression | Cers4 | 0.42 | 2124 | 0.32 | 2.6e-14 | 5.68 | 1.38e-08 | 0.52 | FALSE |
| pVTA | Snapc2 | isoform ratio | XM_039089313.1 | 0.51 | 13 | 0.08 | 3.1e-04 | 5.33 | 1.00e-07 | 0.63 | TRUE |