Hub : Genes

Mir628

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000056387 0.04 0.03 3.5e-03 0.04 0.03 0.03 0.04 1.5e-04 2e-03 1.1e-03 2.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
BMI with tail5.116.616.6-4.1
BMI without tail0.91.91.9-1.4
Body weight2.912.412.4-3.5
Epididymis fat weight0.51.11.11.1
Glucose0.60.90.9-0.9
Heart weight0.00.00.0-0.1
Left kidney weight2.15.95.9-2.4
Right kidney weight1.02.82.8-1.7
Tail length0.41.21.21.1
Length with tail0.10.50.5-0.7
Length without tail2.75.95.9-2.4
Liver weight, left1.11.81.8-1.4
Liver weight, right1.72.92.9-1.7
Parametrial fat weight0.81.61.61.2
Retroperitoneal fat weight0.20.80.80.9
Intraocular pressure0.10.10.10.3
Extensor digitorum longus weight6.526.026.0-5.1
Soleus weight14.341.841.8-6.5
Tibialis anterior weight14.951.451.4-7.2
Tibia length0.20.60.6-0.7
Number of licking bursts1.51.71.71.3
Food consumed during 24 hour testing period2.53.03.0-1.7
Times rat made contact with spout0.00.00.00.0
Mean time between licks in bursts0.71.01.01.0
Mean num. licks in bursts1.82.12.1-1.5
Std. dev. time between licks in bursts0.00.00.00.1
Water consumed over 24 hours0.00.00.0-0.0
Indifference point 0 sec0.00.00.0-0.2
Indifference point AUC2.52.92.91.7
Indifference point function ln k3.65.15.1-2.3
Indifference point function log k3.65.15.1-2.3
Delay discounting total patch changes 0 sec0.10.10.1-0.3
Delay discounting total patch changes 12 sec1.11.41.41.2
Delay discounting total patch changes 18 sec0.20.30.30.6
Delay discounting total patch changes 24 sec1.01.21.21.1
Delay discounting total patch changes 6 sec0.81.11.11.1
Delay discounting time to switch 0 sec0.40.60.60.8
Delay discounting water rate 0 sec1.72.72.7-1.6
Delay discounting water rate 12 sec2.03.03.0-1.7
Delay discounting water rate 18 sec0.10.20.2-0.4
Delay discounting water rate 24 sec0.30.40.40.6
Delay discounting water rate 6 sec0.10.10.1-0.3
Locomotor activity5.48.58.5-2.9
Locomotor testing distance3.35.55.5-2.3
Locomotor testing rearing0.71.21.2-1.1
Light reinforcement 11.12.12.1-1.4
Light reinforcement 20.00.10.1-0.3
Reaction time number correct1.92.72.7-1.6
Reaction time mean minus median0.30.40.40.6
Reaction time mean minus median AUC1.01.31.31.1
Reaction time num false alarms0.10.20.20.5
Reaction time num false alarms AUC0.00.00.00.1
Reaction time trials correct on left1.92.72.7-1.6
Reaction time trials on left1.82.62.6-1.6
Reaction time mean2.02.72.71.6
Reaction time mean AUC2.12.82.81.7
Median of all reaction times2.43.23.21.8
Reaction time omissions0.00.00.00.1
Reaction time false alarm rate0.91.21.21.1
Reaction time premature initiation rate1.31.81.8-1.3
Reaction time premature initiations3.04.24.2-2.1
Std. dev. reaction times1.62.22.21.5
Reaction time trials completed1.82.62.6-1.6
Reaction time trials AUC1.62.32.3-1.5
Social response proportion1.51.61.6-1.3
Social responses0.10.10.1-0.3
Social time0.10.20.2-0.4
Conditioned locomotion0.10.10.1-0.4
Cocaine response after cond. corrected7.48.38.3-2.9
Cocaine response after cond. not corrected6.26.96.9-2.6
Cocaine response before conditioning0.91.11.11.0
Saline control response0.00.00.0-0.2
Condit. Reinf. active minus inactive responses2.02.52.5-1.6
Condit. Reinf. active-inactive response ratio2.72.82.8-1.7
Condit. Reinf. active responses0.91.21.2-1.1
Condit. Reinf. inactive responses0.91.11.11.1
Condit. Reinf. lever presses0.00.00.00.0
Condit. Reinf. lever reinforcers received0.60.90.9-0.9
Pavlov. Cond. lever latency0.91.31.3-1.1
Pavlov. Cond. magazine entry latency4.75.45.42.3
Pavlov. Cond. change in total contacts1.31.91.91.4
Pavlov. Cond. index score2.33.03.01.7
Pavlov. Cond. latency score1.62.02.01.4
Pavlov. Cond. lever contacts0.50.70.70.9
Pavlov. Cond. magazine entry number4.45.45.4-2.3
Pavlov. Cond. intertrial magazine entries0.91.11.1-1.1
Pavlov. Cond. lever-magazine prob. diff.2.63.43.41.8
Pavlov. Cond. response bias2.33.23.21.8
Conditioned reinforcement - actives0.10.10.1-0.3
Conditioned reinforcement - inactives0.00.00.0-0.1
Conditioned locomotion0.10.10.10.3
Intermittent access intake day 1-15 change0.10.10.10.3
Intermittent access intake escalation0.00.00.00.2
Intermittent access intake escalation 20.10.10.1-0.3
Intermitt. access day 1 inactive lever presses0.00.00.00.1
Intermitt. access day 15 inactive lever presses0.40.50.50.7
Intermitt. access escalation Index0.20.20.2-0.5
Intermittent access day 1 total infusions0.00.00.00.2
Intermittent access day 15 total infusions0.10.10.10.4
Intermittent access terminal intake (last 3 days)0.00.00.00.0
Intermittent access total infusions0.00.00.0-0.2
Intermittent access day 1 locomotion0.10.10.10.3
Intermittent access day 15 total locomotion0.10.10.10.2
Intermittent access total locomotion0.10.10.1-0.4
Intermittent access standard deviation0.00.00.00.1
Cocaine induced anxiety0.30.40.40.6
Post-drug Anxiety2.42.72.71.6
Baseline Anxiety1.31.31.31.2
Lifetime Intake0.00.00.00.1
Incentive Sensitization - Responses0.80.80.8-0.9
Incentive Sensitization - Breakpoint0.50.50.5-0.7
Progressive ratio test 1 active lever presses0.80.80.8-0.9
Progressive ratio test 1 breakpoint0.40.40.4-0.6
Progressive ratio test 1 inactive lever presses0.00.00.00.1
Progressive ratio test 2 active lever presses0.50.50.5-0.7
Progressive ratio test 2 breakpoint0.80.90.9-0.9
Progressive ratio test 2 inactive lever presses0.20.20.20.5
Total sessions with >9 infusions0.91.01.0-1.0
Short access day 1 total inactive lever presses1.21.41.4-1.2
Short access day 10 total inactive lever presses0.30.30.30.6
Short access day 1 total infusions0.40.40.4-0.6
Short access day 10 total infusions0.00.00.00.1
Short access total infusions0.00.00.0-0.0
Short access day 1 locomotion0.40.40.4-0.6
Short access day 10 total locomotion0.91.01.0-1.0
Short access total locomotion0.00.00.0-0.1
Compulsive drug intake1.11.11.1-1.0
One hour access (0.3 mA shock)0.60.60.6-0.8
One hour access (shock baseline)0.10.10.10.4
Number of responses in last shaping day0.40.40.4-0.6
Context. condit. distance diff. score0.00.00.00.0
Locomotion velocity, session 10.80.80.8-0.9
Locomotion distance, session 10.20.20.20.5
Locomotion velocity, session 20.10.10.10.4
Locomotion distance, session 20.00.00.00.1
Locomotion velocity, session 30.10.10.10.3
Locomotion distance, session 32.83.03.01.7
Stereotopy head waving bouts, day 31.11.31.3-1.1
Stereotopy head waving duration, day 31.72.12.1-1.4
Locomotion velocity, session 71.11.21.21.1
Locomotion distance, session 72.22.82.81.7
Stereotopy head waving bouts, day 70.30.30.3-0.6
Stereotopy head waving duration, day 70.50.60.6-0.8
Locomotion velocity, session 80.10.10.1-0.3
Locomotion distance, session 80.71.01.01.0
Degree of sensitization distance0.20.20.20.5
Degree of sensitization stereotypy0.30.30.3-0.6
Condit. Reinf. active minus inactive responses1.01.11.11.0
Condit. Reinf. active-inactive response ratio0.10.10.10.3
Condit. Reinf. active responses0.81.01.01.0
Condit. Reinf. inactive responses0.70.80.80.9
Incentive salience index mean0.30.40.40.6
Condit. Reinf. lever presses0.00.10.10.2
Time in familiar zone, hab. session 10.10.10.10.3
Time in novel zone, hab. session 10.00.00.00.1
Total zone transitions, hab. session 11.01.51.51.2
Total locomotion distance, hab. session 10.40.60.60.8
Locomotion velocity, hab. session 10.10.20.20.4
Time in familiar zone, hab. session 20.10.10.10.2
Time in novel zone, hab. session 20.30.30.3-0.6
Total zone transitions, hab. session 20.30.40.40.7
Total locomotion distance, hab. session 20.10.20.20.4
Locomotion velocity, hab. session 20.10.20.20.4
Novel to familiar place preference ratio1.01.11.1-1.0
Novelty place preference1.31.41.4-1.2
Time in novel zone, NPP test1.92.02.0-1.4
Total zone transitions, NPP test0.10.20.20.4
Total locomotion distance, NPP test0.10.10.10.3
Locomotion velocity, NPP test0.40.60.60.8
Pavlov. Cond. lever latency0.40.50.5-0.7
Pavlov. Cond. magazine entry latency3.64.74.72.2
Pavlov. Cond. change in total contacts0.60.70.70.8
Pavlov. Cond. index score3.03.83.82.0
Pavlov. Cond. latency score2.53.13.11.8
Pavlov. Cond. lever contacts0.70.90.90.9
Pavlov. Cond. magazine entry number4.35.35.3-2.3
Pavlov. Cond. intertrial magazine entries0.00.00.00.1
Pavlov. Cond. lever-magazine prob. diff.2.63.23.21.8
Pavlov. Cond. response bias2.22.72.71.6
Bone: apparent density0.20.30.30.6
Bone surface0.10.20.2-0.4
Bone volume0.20.30.3-0.5
Bone: connectivity density2.03.23.21.8
Bone: cortical apparent density0.40.50.50.7
Bone: cortical area1.52.32.3-1.5
Bone: cortical porosity0.40.40.40.6
Bone: cortical porosity0.91.01.01.0
Bone: cortical thickness0.00.00.00.0
Bone: cortical thickness0.10.10.1-0.3
Bone: cortical tissue density0.50.70.70.8
Bone: elastic displacement0.00.00.0-0.1
Bone: elastic work0.00.00.0-0.2
Bone: endosteal estimation3.16.76.7-2.6
Bone: endosteal perimeter4.08.38.3-2.9
Bone: final force1.62.72.7-1.6
Bone: final moment1.52.52.5-1.6
Bone: marrow area3.47.47.4-2.7
Bone: maximum diameter3.97.17.1-2.7
Bone: maximum force1.52.62.6-1.6
Bone: maximum moment1.42.52.5-1.6
Bone: minimum diameter0.40.80.8-0.9
Bone: periosteal estimation3.47.07.0-2.6
Bone: periosteal perimeter3.86.36.3-2.5
Bone: post-yield work0.10.10.1-0.3
Bone: stiffness1.82.82.8-1.7
Bone: tissue strength0.50.50.50.7
Bone: trabecular number1.32.12.11.4
Bone: trabecular spacing0.00.00.0-0.0
Bone: trabecular thickness0.40.50.5-0.7
Bone: trabecular tissue density11.115.615.6-3.9
Breakpoint value in progressive ratio session0.10.10.10.3
Distance traveled before self-admin0.30.30.3-0.5
Distance traveled after self-admin3.74.14.1-2.0
Delta time in closed arm before/after self-admin0.20.20.2-0.4
Delta time in open arm before/after self-admin0.70.60.60.8
Diff in mean of infusions in LGA sessions0.80.90.9-1.0
Extinction: sum of active levers before priming0.60.60.60.8
Active lever presses in extinction session 60.00.00.0-0.0
Delta distance traveled before/after self-admin4.24.54.5-2.1
Delta ambulatory time before/after self-admin3.13.33.3-1.8
Time in closed arm before self-admin0.40.40.40.7
Time in closed arm after self-admin0.00.00.0-0.1
Time in open arm before self-admin1.82.02.0-1.4
Time in open arm after self-admin0.20.30.3-0.5
Sum of active levers in priming session hrs 5-60.40.40.4-0.6
Time to tail flick, vehicle, before self-admin1.11.11.11.0
Time to tail flick, vehicle, after self-admin1.41.51.5-1.2
Time to tail flick, test, before self-admin2.42.32.31.5
Time to tail flick, test, after self-admin1.71.81.81.3
Delta time to tail flick, vehicle, before/after SA1.21.21.2-1.1
Delta time to tail flick, test, before/after SA0.40.30.3-0.6
Ambulatory time before self-admin0.10.10.10.2
Ambulatory time after self-admin3.33.63.6-1.9
Total heroin consumption0.40.50.5-0.7
Area under the delay curve0.00.00.00.2
Delay disc. indifference point, 0s delay2.83.03.01.7
Delay disc. indifference point, 16s delay0.00.00.00.1
Delay disc. indifference point, 2s delay0.10.10.10.3
Delay disc. indifference point, 24s delay0.30.30.30.6
Delay disc. indifference point, 4s delay0.50.50.50.7
Delay disc. indifference point, 8s delay0.00.00.0-0.2
Delay discount exponential model param0.00.00.0-0.1
Delay discount hyperbolic model param0.00.00.0-0.2
Fecal boli incidents, locomotor time 10.40.40.40.7
Change in fecal boli incidents, locomotor task4.24.04.0-2.0
Time >=10cm from walls, locomotor time 11.71.71.7-1.3
Bouts of movement, locomotor time 10.00.00.0-0.2
Total resting periods, locomotor time 10.00.00.0-0.1
Rest time, locomotor task time 10.00.00.00.0
Distance moved, locomotor task time 10.20.20.20.4
Vertical activity count, locomotor time 10.10.10.10.4
Time >=10cm from walls, locomotor time 20.00.00.0-0.1
Bouts of movement, locomotor time 20.00.00.0-0.2
Total resting periods, locomotor time 20.10.10.1-0.3
Rest time, locomotor task time 20.00.00.00.0
Distance moved, locomotor task time 20.10.10.10.3
Vertical activity count, locomotor time 20.80.90.91.0
Weight adjusted by age6.27.07.0-2.6
Seeking ratio, delayed vs. immediate footshock1.21.31.3-1.2
Locomotion in novel chamber0.10.10.1-0.3
Locomotion in novel chamber post-restriction0.40.40.40.7
Progressive ratio0.00.00.00.2
Food seeking constrained by brief footshock0.50.60.6-0.8
Seeking ratio, punishment vs. effort1.41.71.7-1.3
Run reversals in cocaine runway, females0.40.40.4-0.6
Run reversals in cocaine runway, males0.20.20.20.4
Latency to leave start box in cocaine runway1.21.31.3-1.2
Latency to leave start box in cocaine runway, F0.00.00.0-0.2
Latency to leave start box in cocaine runway, M2.01.91.9-1.4
Cd content in liver1.01.11.11.1
Co content in liver0.20.20.20.5
Cu content in liver0.60.70.7-0.8
Fe content in liver1.41.61.61.3
K content in liver0.90.90.9-1.0
Mg content in liver2.93.03.0-1.7
Mn content in liver1.82.02.0-1.4
Na content in liver1.61.71.7-1.3
Rb content in liver1.21.51.5-1.2
Se content in liver0.60.70.70.9
Sr content in liver1.00.90.91.0
Zn content in liver0.00.00.00.1