Lrp5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000015911	0.12	0.06	3.7e-10	0.04	0.07	0.07	0.07	2.7e-05	1.2e-08	1.1e-08	2.8e-08
2	Adipose	intron excision ratio	chr1:200814711:200817440	0.05	0.03	2.7e-03	0.01	0	-0	0	6.2e-02	2.3e-01	5.4e-01	1.9e-01
3	Adipose	intron excision ratio	chr1:200821108:200821709	0.04	0.03	3.5e-03	0	0	-0	0	2.5e-01	2.8e-01	6.7e-01	2.7e-01
4	BLA	gene expression	ENSRNOG00000015911	0.18	0.12	4.5e-08	0.14	0.13	0.14	0.13	9.8e-08	2.1e-07	3.6e-08	2.0e-07
5	PL	gene expression	ENSRNOG00000015911	0.14	0.09	6.6e-09	0.09	0.1	0.1	0.09	2.6e-07	8.0e-08	1.1e-07	1.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	1.9	6.2	11.4	3.4	-2.5	2.5	0.8	2.6
BMI without tail	1.3	2.8	4.6	2.1	-1.6	1.6	1.4	1.6
Body weight	1.7	7.3	15.1	2.1	-3.9	3.9	1.1	0.7
Epididymis fat weight	1.8	4.1	8.5	-1.1	2.9	-2.9	1.6	0.1
Glucose	1.3	2.0	3.0	0.9	1.7	-1.7	0.6	1.6
Heart weight	1.1	1.6	2.8	-0.2	1.7	-1.7	1.4	0.4
Left kidney weight	0.7	2.0	3.4	-1.5	1.8	-1.8	0.2	-1.0
Right kidney weight	0.8	2.2	3.7	-1.9	1.6	-1.6	0.3	-1.5
Tail length	0.7	2.0	2.5	-0.8	-1.5	1.5	1.6	-1.6
Length with tail	1.2	4.3	9.2	-0.1	-3.0	3.0	1.1	-1.5
Length without tail	1.1	2.4	5.7	0.4	-2.4	2.4	-0.0	-0.6
Liver weight, left	0.1	0.2	0.4	-0.2	0.5	-0.5	-0.6	-0.0
Liver weight, right	0.3	0.5	0.8	-0.9	0.2	-0.2	-0.9	-0.8
Parametrial fat weight	1.0	2.0	4.3	0.3	2.1	-2.1	-0.4	1.2
Retroperitoneal fat weight	2.8	9.1	19.3	-1.5	4.4	-4.4	2.1	0.2
Intraocular pressure	0.8	1.2	2.2	-1.5	0.7	-0.7	-1.0	-1.3
Extensor digitorum longus weight	3.4	13.8	30.4	1.1	-5.5	5.5	-2.4	-0.9
Soleus weight	2.4	7.0	13.0	-2.7	3.6	-3.6	0.2	-1.4
Tibialis anterior weight	4.8	16.6	34.0	-0.6	-5.8	5.8	-2.6	-2.8
Tibia length	0.4	1.0	2.7	-1.3	-0.5	0.5	-0.2	-1.6
Number of licking bursts	0.3	0.4	1.6	0.4	-0.1	0.1	-1.3	0.4
Food consumed during 24 hour testing period	0.5	0.6	1.4	-0.8	0.6	-0.6	-1.2	-0.5
Times rat made contact with spout	0.7	0.8	1.3	1.1	-0.7	0.7	-0.8	0.9
Mean time between licks in bursts	0.5	0.8	1.6	0.3	-1.3	1.3	0.7	-0.2
Mean num. licks in bursts	0.2	0.3	1.0	0.4	-0.1	0.1	1.0	0.3
Std. dev. time between licks in bursts	1.5	1.8	4.4	-1.0	-0.9	0.9	-2.1	-1.4
Water consumed over 24 hours	0.5	0.6	0.9	0.9	-0.9	0.9	0.0	0.6
Indifference point 0 sec	1.3	2.0	8.7	0.0	0.8	-0.8	2.9	0.2
Indifference point AUC	0.8	1.0	1.5	-0.1	-1.2	1.2	-1.2	-0.7
Indifference point function ln k	2.0	2.9	6.6	-1.1	2.6	-2.6	0.3	-0.1
Indifference point function log k	2.0	2.9	6.6	-1.1	2.6	-2.6	0.3	-0.1
Delay discounting total patch changes 0 sec	1.1	1.8	8.4	-0.4	0.5	-0.5	2.9	-0.3
Delay discounting total patch changes 12 sec	1.2	1.6	2.8	0.6	-1.7	1.7	1.4	-0.1
Delay discounting total patch changes 18 sec	0.4	0.5	1.8	0.6	-0.4	0.4	1.4	0.3
Delay discounting total patch changes 24 sec	0.7	0.8	1.6	-0.1	-1.0	1.0	1.3	-0.6
Delay discounting total patch changes 6 sec	1.3	1.9	5.3	1.2	-1.0	1.0	2.3	0.8
Delay discounting time to switch 0 sec	1.9	3.0	6.1	2.5	-1.4	1.4	0.4	2.1
Delay discounting water rate 0 sec	3.8	6.1	10.4	-3.2	2.6	-2.6	-0.3	-2.5
Delay discounting water rate 12 sec	5.9	8.8	12.3	-3.5	3.1	-3.1	-2.5	-2.5
Delay discounting water rate 18 sec	1.8	2.4	5.4	-1.4	1.4	-1.4	-2.3	-0.8
Delay discounting water rate 24 sec	2.5	3.4	6.7	-2.6	1.6	-1.6	-1.0	-2.1
Delay discounting water rate 6 sec	2.1	3.0	5.8	-2.4	1.4	-1.4	-1.3	-2.0
Locomotor activity	0.7	1.2	1.4	-1.1	1.2	-1.2	-1.2	-0.8
Locomotor testing distance	0.7	1.1	1.5	-1.2	1.2	-1.2	-0.6	-0.8
Locomotor testing rearing	0.6	1.0	1.8	0.1	1.2	-1.2	-1.3	0.6
Light reinforcement 1	0.4	0.7	1.1	-1.0	0.9	-0.9	-0.4	-0.6
Light reinforcement 2	1.2	1.6	2.8	-1.4	1.7	-1.7	0.2	-0.7
Reaction time number correct	2.1	3.1	13.3	-0.5	-0.7	0.7	-3.7	-0.9
Reaction time mean minus median	0.9	1.2	2.1	1.2	-1.4	1.4	0.1	0.7
Reaction time mean minus median AUC	0.7	0.9	1.9	0.5	-1.4	1.4	-0.7	-0.0
Reaction time num false alarms	0.4	0.5	1.4	-1.0	-0.2	0.2	0.1	-1.2
Reaction time num false alarms AUC	0.4	0.6	0.9	-0.5	-0.9	0.9	-0.2	-1.0
Reaction time trials correct on left	2.1	3.1	13.3	-0.5	-0.7	0.7	-3.7	-0.9
Reaction time trials on left	2.3	3.3	14.0	-0.6	-0.8	0.8	-3.7	-1.0
Reaction time mean	0.3	0.5	1.4	0.6	0.1	-0.1	1.2	0.7
Reaction time mean AUC	0.4	0.5	1.4	0.7	0.2	-0.2	1.2	0.8
Median of all reaction times	0.5	0.7	2.1	0.7	0.4	-0.4	1.4	0.9
Reaction time omissions	1.1	1.5	2.7	0.5	-1.6	1.6	-1.4	-0.1
Reaction time false alarm rate	0.5	0.7	2.9	-0.5	-0.3	0.3	1.7	-0.6
Reaction time premature initiation rate	1.4	1.9	4.0	0.7	-2.0	2.0	-0.9	-0.1
Reaction time premature initiations	3.0	4.3	8.6	0.3	-2.5	2.5	-2.9	-0.8
Std. dev. reaction times	0.3	0.4	0.6	0.8	-0.6	0.6	0.6	0.6
Reaction time trials completed	2.3	3.3	14.0	-0.6	-0.8	0.8	-3.7	-1.0
Reaction time trials AUC	1.9	2.7	11.6	-0.5	-0.6	0.6	-3.4	-0.9
Social response proportion	0.9	1.0	1.7	1.1	-0.8	0.8	-1.3	0.8
Social responses	1.4	1.8	8.1	-0.1	-0.6	0.6	-2.8	-0.4
Social time	0.9	1.1	3.5	0.4	-1.0	1.0	-1.9	0.1
Conditioned locomotion	2.3	2.7	3.7	-1.0	-1.7	1.7	-1.9	-1.7
Cocaine response after cond. corrected	0.1	0.1	0.1	0.1	0.4	-0.4	0.4	0.3
Cocaine response after cond. not corrected	0.3	0.3	0.6	0.6	0.4	-0.4	0.6	0.7
Cocaine response before conditioning	0.1	0.2	0.4	0.6	-0.2	0.2	-0.2	0.5
Saline control response	1.4	1.8	4.0	1.0	-2.0	2.0	-0.4	0.2
Condit. Reinf. active minus inactive responses	0.8	1.0	2.2	1.1	0.9	-0.9	-0.1	1.5
Condit. Reinf. active-inactive response ratio	1.0	1.1	2.2	0.3	1.5	-1.5	-0.3	0.9
Condit. Reinf. active responses	0.9	1.2	3.2	1.6	0.2	-0.2	0.3	1.8
Condit. Reinf. inactive responses	1.0	1.2	2.3	1.5	-1.0	1.0	0.5	1.2
Condit. Reinf. lever presses	1.2	1.6	3.0	1.5	-0.9	0.9	-1.7	1.2
Condit. Reinf. lever reinforcers received	0.9	1.3	3.4	1.8	-0.0	0.0	0.3	1.8
Pavlov. Cond. lever latency	0.5	0.7	3.1	-0.3	0.2	-0.2	1.8	-0.2
Pavlov. Cond. magazine entry latency	2.6	3.0	4.2	2.0	-1.9	1.9	-1.2	1.4
Pavlov. Cond. change in total contacts	0.6	0.8	1.6	1.3	-0.4	0.4	-0.8	1.1
Pavlov. Cond. index score	1.1	1.5	3.0	1.3	-1.0	1.0	-1.7	0.9
Pavlov. Cond. latency score	1.0	1.3	3.3	1.1	-0.8	0.8	-1.8	0.8
Pavlov. Cond. lever contacts	0.6	0.9	4.2	-0.2	-0.2	0.2	-2.1	-0.3
Pavlov. Cond. magazine entry number	3.0	3.7	5.3	-2.3	2.2	-2.2	1.0	-1.6
Pavlov. Cond. intertrial magazine entries	1.6	2.0	4.8	-1.0	1.4	-1.4	2.2	-0.5
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	2.2	1.4	-1.2	1.2	-1.5	1.0
Pavlov. Cond. response bias	0.9	1.3	3.5	0.9	-0.9	0.9	-1.9	0.6
Conditioned reinforcement - actives	0.5	0.5	1.1	-1.0	0.6	-0.6	0.1	-0.8
Conditioned reinforcement - inactives	3.1	3.5	7.8	-1.1	2.8	-2.8	0.8	-0.1
Conditioned locomotion	5.5	6.6	11.8	-2.6	3.4	-3.4	-0.7	-1.4
Intermittent access intake day 1-15 change	1.3	1.3	2.0	-1.1	1.4	-1.4	-0.9	-0.7
Intermittent access intake escalation	1.2	1.2	2.0	-0.7	1.4	-1.4	-1.1	-0.2
Intermittent access intake escalation 2	0.5	0.5	0.8	-0.8	0.9	-0.9	-0.2	-0.5
Intermitt. access day 1 inactive lever presses	1.1	1.2	2.3	-0.3	1.3	-1.3	1.5	0.2
Intermitt. access day 15 inactive lever presses	1.2	1.3	2.2	-0.2	1.4	-1.4	1.5	0.6
Intermitt. access escalation Index	1.9	1.7	3.3	-1.0	1.8	-1.8	-0.9	-0.5
Intermittent access day 1 total infusions	3.8	4.4	9.9	1.2	1.7	-1.7	3.1	2.2
Intermittent access day 15 total infusions	4.1	4.6	8.5	-0.4	2.9	-2.9	2.2	0.9
Intermittent access terminal intake (last 3 days)	3.7	4.1	8.5	0.1	2.3	-2.3	2.9	1.2
Intermittent access total infusions	2.6	2.9	6.4	0.4	1.8	-1.8	2.5	1.4
Intermittent access day 1 locomotion	2.2	2.2	4.3	1.3	0.9	-0.9	2.1	1.9
Intermittent access day 15 total locomotion	2.0	2.2	5.1	-0.4	2.3	-2.3	-0.3	0.6
Intermittent access total locomotion	3.0	3.3	6.4	0.5	2.5	-2.5	0.9	1.7
Intermittent access standard deviation	0.4	0.4	0.7	-0.5	0.8	-0.8	0.5	-0.1
Cocaine induced anxiety	0.1	0.1	0.1	-0.1	0.3	-0.3	-0.3	-0.0
Post-drug Anxiety	0.5	0.6	1.1	-0.2	-1.1	1.1	0.1	-0.8
Baseline Anxiety	1.2	1.2	2.8	-0.0	-1.7	1.7	-0.3	-0.7
Lifetime Intake	2.6	2.9	8.1	0.4	1.5	-1.5	2.8	1.3
Incentive Sensitization - Responses	0.4	0.4	1.1	-0.1	0.6	-0.6	1.0	0.2
Incentive Sensitization - Breakpoint	0.4	0.4	0.8	-0.2	0.8	-0.8	0.9	0.1
Progressive ratio test 1 active lever presses	1.7	1.7	4.8	-0.8	1.3	-1.3	2.2	-0.2
Progressive ratio test 1 breakpoint	1.8	1.9	5.7	-0.9	1.2	-1.2	2.4	-0.4
Progressive ratio test 1 inactive lever presses	0.6	0.6	2.3	-0.1	0.7	-0.7	1.5	0.2
Progressive ratio test 2 active lever presses	2.7	2.9	7.3	-0.7	1.8	-1.8	2.7	0.1
Progressive ratio test 2 breakpoint	3.1	3.5	6.8	-1.3	2.1	-2.1	2.6	-0.4
Progressive ratio test 2 inactive lever presses	4.6	5.3	8.6	-0.7	2.9	-2.9	2.9	0.7
Total sessions with >9 infusions	0.4	0.4	0.7	-0.0	0.8	-0.8	0.8	0.5
Short access day 1 total inactive lever presses	2.1	2.3	6.0	-0.4	1.6	-1.6	2.4	0.3
Short access day 10 total inactive lever presses	0.8	0.9	1.6	-0.3	1.3	-1.3	1.1	0.3
Short access day 1 total infusions	2.2	2.4	7.8	0.3	1.2	-1.2	2.8	1.1
Short access day 10 total infusions	2.2	2.4	4.7	1.6	0.6	-0.6	2.1	2.2
Short access total infusions	1.7	1.9	6.8	0.8	0.5	-0.5	2.6	1.3
Short access day 1 locomotion	1.0	1.1	1.7	0.5	1.3	-1.3	0.6	1.1
Short access day 10 total locomotion	0.5	0.5	1.0	0.7	0.7	-0.7	0.2	1.0
Short access total locomotion	0.7	0.7	1.4	0.7	0.6	-0.6	1.2	1.0
Compulsive drug intake	1.9	1.9	4.3	-0.0	-2.1	2.1	0.0	-1.0
One hour access (0.3 mA shock)	4.5	5.3	8.5	-1.0	2.9	-2.9	2.9	0.3
One hour access (shock baseline)	4.9	5.6	10.9	-1.2	3.3	-3.3	2.2	0.2
Number of responses in last shaping day	0.3	0.3	0.6	-0.6	0.8	-0.8	0.4	-0.3
Context. condit. distance diff. score	0.5	0.7	1.4	0.0	1.2	-1.2	0.5	0.4
Locomotion velocity, session 1	0.6	0.6	2.9	0.2	0.1	-0.1	-1.7	0.1
Locomotion distance, session 1	1.8	2.4	5.3	1.8	-0.6	0.6	-2.3	1.6
Locomotion velocity, session 2	1.4	1.6	3.1	0.6	-1.8	1.8	-1.2	-0.1
Locomotion distance, session 2	1.5	2.1	5.7	1.3	-1.1	1.1	-2.4	0.9
Locomotion velocity, session 3	0.9	1.1	2.7	1.6	-0.1	0.1	0.3	1.6
Locomotion distance, session 3	0.1	0.1	0.1	0.4	0.0	-0.0	-0.2	0.4
Stereotopy head waving bouts, day 3	1.5	1.8	4.5	1.3	0.4	-0.4	2.1	1.5
Stereotopy head waving duration, day 3	1.1	1.4	3.4	0.6	1.0	-1.0	1.8	1.0
Locomotion velocity, session 7	0.8	0.9	1.6	1.1	0.0	-0.0	1.2	1.3
Locomotion distance, session 7	0.4	0.5	1.8	0.6	-0.4	0.4	-1.4	0.4
Stereotopy head waving bouts, day 7	2.1	2.4	8.4	1.0	0.6	-0.6	2.9	1.4
Stereotopy head waving duration, day 7	2.4	2.9	6.8	1.8	-0.9	0.9	2.6	1.6
Locomotion velocity, session 8	0.7	0.9	1.7	0.7	-1.3	1.3	-0.7	0.1
Locomotion distance, session 8	0.6	0.9	3.1	0.5	0.6	-0.6	-1.7	0.7
Degree of sensitization distance	0.3	0.3	0.5	0.7	-0.4	0.4	-0.5	0.6
Degree of sensitization stereotypy	1.2	1.3	4.1	1.1	-0.4	0.4	2.0	1.0
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	0.8	-0.3	0.3	-0.7	0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.5	0.1	-0.1	0.0	0.6
Condit. Reinf. active responses	0.0	0.1	0.1	0.2	-0.1	0.1	-0.4	0.3
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.0	-0.3
Incentive salience index mean	0.6	0.8	2.8	0.7	-0.3	0.3	-1.7	0.6
Condit. Reinf. lever presses	0.7	1.0	4.8	-0.2	-0.1	0.1	-2.2	-0.2
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.3	0.8	-0.8	-0.0	0.6
Time in novel zone, hab. session 1	0.0	0.0	0.1	-0.2	-0.3	0.3	0.1	-0.3
Total zone transitions, hab. session 1	0.8	1.1	3.7	0.6	-0.8	0.8	-1.9	0.4
Total locomotion distance, hab. session 1	0.6	0.9	2.8	-0.0	0.9	-0.9	-1.7	0.4
Locomotion velocity, hab. session 1	0.7	0.9	4.4	-0.1	0.4	-0.4	-2.1	0.2
Time in familiar zone, hab. session 2	0.6	0.6	0.8	-0.5	-0.8	0.8	-0.8	-0.9
Time in novel zone, hab. session 2	0.9	0.9	1.6	1.1	0.3	-0.3	1.2	1.3
Total zone transitions, hab. session 2	2.6	3.4	7.7	2.8	-1.1	1.1	-0.8	2.5
Total locomotion distance, hab. session 2	0.9	1.2	2.5	1.4	0.1	-0.1	-1.2	1.6
Locomotion velocity, hab. session 2	0.8	1.1	2.3	1.3	0.4	-0.4	-1.1	1.5
Novel to familiar place preference ratio	1.1	1.1	3.7	0.9	-0.5	0.5	1.9	0.8
Novelty place preference	1.2	1.3	4.8	0.8	-0.2	0.2	2.2	0.9
Time in novel zone, NPP test	1.2	1.2	4.6	0.9	-0.2	0.2	2.1	0.9
Total zone transitions, NPP test	2.3	3.2	9.7	1.7	-1.1	1.1	-3.1	1.3
Total locomotion distance, NPP test	1.5	2.0	8.9	0.7	0.2	-0.2	-3.0	0.8
Locomotion velocity, NPP test	1.4	2.0	9.1	0.5	0.3	-0.3	-3.0	0.6
Pavlov. Cond. lever latency	0.4	0.5	1.8	-0.5	0.3	-0.3	1.3	-0.4
Pavlov. Cond. magazine entry latency	0.7	0.9	2.0	1.2	0.4	-0.4	0.7	1.4
Pavlov. Cond. change in total contacts	0.4	0.4	0.6	0.4	0.8	-0.8	-0.2	0.8
Pavlov. Cond. index score	0.3	0.4	1.7	0.0	0.4	-0.4	-1.3	0.2
Pavlov. Cond. latency score	0.2	0.3	1.0	0.3	0.3	-0.3	-1.0	0.4
Pavlov. Cond. lever contacts	0.4	0.5	2.2	0.3	0.0	-0.0	-1.5	0.3
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.2	-0.5	0.5	0.7	0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	-1.1	0.2	-0.2	0.7	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.5	0.1	0.3	-0.3	-1.2	0.2
Pavlov. Cond. response bias	0.1	0.1	0.4	0.0	0.4	-0.4	-0.6	0.2
Bone: apparent density	1.6	2.6	6.3	2.5	-0.4	0.4	-0.3	2.5
Bone surface	2.6	4.6	8.5	2.9	-1.7	1.7	-1.8	2.4
Bone volume	1.4	2.3	5.3	2.3	-0.6	0.6	-0.7	2.2
Bone: connectivity density	2.8	4.4	8.9	3.0	-1.6	1.6	-1.3	2.5
Bone: cortical apparent density	0.4	0.5	1.0	-0.0	-1.0	1.0	0.4	-0.4
Bone: cortical area	0.6	0.9	2.1	-0.5	-0.9	0.9	-1.5	-0.9
Bone: cortical porosity	0.0	0.0	0.1	0.3	-0.0	0.0	0.2	0.3
Bone: cortical porosity	0.2	0.2	0.4	0.3	-0.6	0.6	0.2	0.1
Bone: cortical thickness	3.3	5.5	8.3	-0.9	-2.9	2.9	-2.4	-2.0
Bone: cortical thickness	1.4	1.6	3.1	-0.2	-1.7	1.7	-1.0	-0.9
Bone: cortical tissue density	0.4	0.6	1.2	-0.0	-1.1	1.1	0.4	-0.5
Bone: elastic displacement	1.6	1.8	4.4	-2.1	0.2	-0.2	-0.7	-2.1
Bone: elastic work	1.4	1.8	2.4	-0.8	-1.5	1.5	-1.3	-1.4
Bone: endosteal estimation	1.1	2.3	4.2	0.8	2.1	-2.1	0.4	1.6
Bone: endosteal perimeter	2.2	4.6	8.2	1.1	2.9	-2.9	0.9	2.2
Bone: final force	1.1	1.8	3.1	1.1	-1.8	1.8	-1.1	0.5
Bone: final moment	0.9	1.5	2.7	1.0	-1.6	1.6	-0.9	0.4
Bone: marrow area	1.1	2.4	4.3	0.8	2.1	-2.1	0.5	1.5
Bone: maximum diameter	0.3	0.5	1.7	-0.5	0.5	-0.5	-1.3	-0.3
Bone: maximum force	1.7	2.9	5.6	2.4	-1.6	1.6	-0.7	1.9
Bone: maximum moment	1.4	2.4	4.7	2.2	-1.4	1.4	-0.6	1.7
Bone: minimum diameter	1.1	2.0	4.0	1.4	1.4	-1.4	0.2	2.0
Bone: periosteal estimation	0.1	0.3	0.5	0.1	0.7	-0.7	-0.6	0.3
Bone: periosteal perimeter	0.2	0.4	0.7	0.6	0.6	-0.6	-0.5	0.8
Bone: post-yield work	4.2	5.7	14.5	3.4	0.8	-0.8	1.3	3.8
Bone: stiffness	1.5	2.5	5.3	2.3	-1.2	1.2	-0.3	2.0
Bone: tissue strength	0.7	0.7	2.7	0.3	0.5	-0.5	-1.7	0.5
Bone: trabecular number	1.4	2.2	5.3	2.3	-0.4	0.4	-0.6	2.2
Bone: trabecular spacing	0.5	0.6	1.5	-1.2	0.3	-0.3	0.2	-1.2
Bone: trabecular thickness	1.1	1.3	2.7	1.2	0.8	-0.8	1.1	1.6
Bone: trabecular tissue density	3.5	4.9	8.5	-2.3	2.9	-2.9	0.5	-1.3
Breakpoint value in progressive ratio session	1.3	1.4	2.5	0.8	-1.6	1.6	-1.1	0.2
Distance traveled before self-admin	0.4	0.4	1.8	0.5	-0.2	0.2	-1.3	0.4
Distance traveled after self-admin	0.0	0.0	0.1	0.3	0.0	-0.0	0.2	0.3
Delta time in closed arm before/after self-admin	0.8	0.7	1.4	-0.2	-0.9	0.9	-1.2	-0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.1	0.5	-0.5	-0.3	0.3
Diff in mean of infusions in LGA sessions	0.3	0.4	0.9	-0.0	-0.6	0.6	-0.9	-0.3
Extinction: sum of active levers before priming	2.8	2.8	3.9	1.6	-1.9	1.9	-2.0	0.8
Active lever presses in extinction session 6	1.3	1.3	2.2	-0.7	-1.1	1.1	-1.5	-1.2
Delta distance traveled before/after self-admin	0.0	0.0	0.2	-0.1	0.1	-0.1	0.4	-0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.8	-0.1	-0.3	0.3	0.9	-0.2
Time in closed arm before self-admin	0.3	0.3	1.1	0.2	0.4	-0.4	1.1	0.4
Time in closed arm after self-admin	0.1	0.1	0.2	-0.3	-0.3	0.3	0.1	-0.4
Time in open arm before self-admin	0.5	0.5	1.9	-0.1	-0.5	0.5	-1.4	-0.4
Time in open arm after self-admin	0.1	0.1	0.6	-0.2	-0.0	0.0	-0.8	-0.3
Sum of active levers in priming session hrs 5-6	1.8	1.8	4.0	-1.7	-0.3	0.3	-1.4	-2.0
Time to tail flick, vehicle, before self-admin	1.6	1.6	3.5	1.9	-0.6	0.6	0.9	1.8
Time to tail flick, vehicle, after self-admin	1.4	1.5	2.8	1.2	-1.7	1.7	0.5	0.5
Time to tail flick, test, before self-admin	1.0	0.9	2.6	1.4	0.2	-0.2	0.4	1.6
Time to tail flick, test, after self-admin	0.4	0.4	1.9	0.0	-0.3	0.3	1.4	-0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.9	0.1	-1.0	1.0	-0.3	-0.3
Delta time to tail flick, test, before/after SA	1.9	1.7	3.8	-1.5	-0.9	0.9	1.0	-1.9
Ambulatory time before self-admin	0.8	0.8	3.2	0.6	-0.0	0.0	-1.8	0.6
Ambulatory time after self-admin	0.6	0.7	1.4	0.8	0.8	-0.8	0.2	1.2
Total heroin consumption	2.1	2.5	5.7	0.8	-2.4	2.4	0.6	-0.1
Area under the delay curve	0.6	0.6	1.4	1.0	-0.0	0.0	0.8	1.2
Delay disc. indifference point, 0s delay	1.3	1.4	2.8	1.5	-0.0	0.0	1.4	1.7
Delay disc. indifference point, 16s delay	0.7	0.7	1.5	-0.2	1.2	-1.2	0.6	0.4
Delay disc. indifference point, 2s delay	0.4	0.4	0.7	0.6	0.6	-0.6	-0.5	0.9
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	-0.4	-0.4	0.4	0.1	-0.6
Delay disc. indifference point, 4s delay	0.2	0.3	0.6	0.7	-0.2	0.2	-0.4	0.7
Delay disc. indifference point, 8s delay	0.6	0.6	1.9	0.7	-0.3	0.3	1.4	0.7
Delay discount exponential model param	0.4	0.4	1.0	-0.9	0.1	-0.1	-0.4	-1.0
Delay discount hyperbolic model param	0.3	0.4	1.0	-0.9	0.1	-0.1	-0.0	-1.0
Fecal boli incidents, locomotor time 1	0.4	0.4	2.0	-0.1	0.2	-0.2	-1.4	0.0
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	0.6	-0.5	0.5	1.0	0.4
Time >=10cm from walls, locomotor time 1	1.7	1.7	3.2	1.1	1.2	-1.2	1.0	1.8
Bouts of movement, locomotor time 1	1.1	1.3	4.2	-0.4	-0.8	0.8	-2.0	-0.9
Total resting periods, locomotor time 1	1.2	1.3	5.1	-0.5	-0.4	0.4	-2.3	-0.8
Rest time, locomotor task time 1	1.7	1.8	2.6	-1.6	1.2	-1.2	-1.6	-1.2
Distance moved, locomotor task time 1	1.2	1.3	3.4	1.2	-0.2	0.2	1.8	1.3
Vertical activity count, locomotor time 1	2.5	2.6	10.2	0.3	1.1	-1.1	3.2	0.8
Time >=10cm from walls, locomotor time 2	0.6	0.6	2.4	-0.6	0.3	-0.3	-1.5	-0.4
Bouts of movement, locomotor time 2	0.5	0.6	1.4	0.0	-0.8	0.8	-1.2	-0.3
Total resting periods, locomotor time 2	0.3	0.3	1.0	0.2	-0.5	0.5	-1.0	-0.0
Rest time, locomotor task time 2	1.3	1.6	2.3	0.2	1.5	-1.5	1.5	0.9
Distance moved, locomotor task time 2	0.5	0.5	0.9	-0.4	-1.0	1.0	-0.1	-0.8
Vertical activity count, locomotor time 2	1.1	1.2	3.3	-1.5	-0.3	0.3	-0.1	-1.8
Weight adjusted by age	1.2	1.4	3.1	0.4	-1.3	1.3	-1.8	-0.1
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	2.5	1.0	-0.3	0.3	1.6	1.0
Locomotion in novel chamber	2.6	3.2	7.7	-0.7	2.8	-2.8	-0.1	0.5
Locomotion in novel chamber post-restriction	1.4	1.6	3.4	-0.9	1.8	-1.8	0.8	-0.1
Progressive ratio	3.6	4.2	7.5	2.7	-1.4	1.4	2.0	2.3
Food seeking constrained by brief footshock	0.6	0.7	2.2	0.4	-0.8	0.8	1.5	0.2
Seeking ratio, punishment vs. effort	1.9	2.4	4.9	-2.2	1.1	-1.1	-1.1	-1.9
Run reversals in cocaine runway, females	1.6	1.6	3.0	1.7	-1.2	1.2	-0.4	1.5
Run reversals in cocaine runway, males	1.1	1.1	2.6	-0.9	-0.6	0.6	-1.6	-1.1
Latency to leave start box in cocaine runway	0.6	0.7	1.7	1.1	0.5	-0.5	0.2	1.3
Latency to leave start box in cocaine runway, F	0.4	0.4	1.2	1.0	0.2	-0.2	-0.1	1.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.1	0.3	-0.3	0.0	0.2
Cd content in liver	1.0	1.1	2.2	-1.0	1.5	-1.5	-0.0	-0.5
Co content in liver	0.7	0.9	1.9	-1.4	0.4	-0.4	-0.6	-1.3
Cu content in liver	0.3	0.3	1.1	-0.2	-0.4	0.4	1.1	-0.3
Fe content in liver	0.6	0.7	3.4	0.1	-0.3	0.3	-1.8	-0.0
K content in liver	1.5	1.5	2.9	1.7	-1.1	1.1	0.4	1.4
Mg content in liver	2.0	2.0	4.5	1.9	0.2	-0.2	1.4	2.1
Mn content in liver	0.8	0.9	1.7	0.7	-1.3	1.3	-0.7	0.2
Na content in liver	0.2	0.2	0.5	-0.5	-0.2	0.2	0.0	-0.7
Rb content in liver	1.8	2.3	3.4	1.3	1.3	-1.3	1.7	1.8
Se content in liver	0.6	0.7	1.3	0.8	0.5	-0.5	1.1	1.1
Sr content in liver	1.6	1.5	2.6	-0.3	-1.6	1.6	-1.0	-1.0
Zn content in liver	0.4	0.5	1.1	0.3	-1.0	1.0	0.1	-0.2