Hub : Genes

Traf3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000008145	0.02	0.02	9.8e-03	0.01	0.01	0.01	0.01	1.7e-02	1.8e-02	2.6e-02	2.7e-02
2	BLA	gene expression	ENSRNOG00000008145	0.05	0.05	6.9e-03	0.02	0.04	0.04	0.03	2.1e-02	4.9e-03	3.5e-03	8.3e-03
3	Brain	gene expression	ENSRNOG00000008145	0.19	0.11	3.6e-14	0.15	0.15	0.14	0.14	5.4e-14	1.6e-13	3.1e-13	3.0e-13
4	Brain	intron excision ratio	chr6:130206593:130259671	0.03	0.02	2.9e-03	0.02	0.03	0.02	0.02	1.1e-02	2.1e-03	6.0e-03	7.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	1.0	3.1	7.4	-0.5	-0.9	-2.7	2.0
BMI without tail	0.4	0.8	1.3	1.1	-1.0	-1.0	0.1
Body weight	0.3	1.4	3.0	1.7	1.0	0.7	-1.1
Epididymis fat weight	3.6	8.5	12.1	-2.8	-1.9	-3.5	3.2
Glucose	0.6	1.0	2.4	0.3	1.6	0.9	-0.7
Heart weight	0.2	0.2	0.8	-0.1	-0.9	-0.3	0.2
Left kidney weight	0.5	1.3	2.0	1.4	0.5	1.2	-1.3
Right kidney weight	0.2	0.6	1.0	1.0	0.3	0.8	-0.9
Tail length	2.6	7.7	10.4	3.1	1.3	3.0	-3.2
Length with tail	2.8	10.2	13.9	2.9	2.4	3.7	-3.6
Length without tail	1.2	2.7	4.5	0.7	2.1	1.9	-1.4
Liver weight, left	3.4	5.5	9.5	3.1	0.6	2.2	-2.7
Liver weight, right	0.1	0.1	0.4	0.6	-0.2	0.1	-0.2
Parametrial fat weight	0.1	0.2	0.7	0.8	0.2	-0.1	-0.5
Retroperitoneal fat weight	0.1	0.3	0.9	0.1	-0.3	-1.0	0.4
Intraocular pressure	0.1	0.2	0.4	-0.7	0.0	-0.3	0.3
Extensor digitorum longus weight	5.2	21.0	26.2	4.8	3.0	5.1	-5.1
Soleus weight	0.0	0.1	0.2	-0.4	-0.4	-0.0	0.3
Tibialis anterior weight	0.3	1.1	1.5	1.2	0.3	1.2	-1.2
Tibia length	0.3	0.8	1.9	0.4	-0.1	1.4	-1.1
Number of licking bursts	0.5	0.6	1.6	1.3	-0.5	0.4	-0.7
Food consumed during 24 hour testing period	0.2	0.2	0.3	0.5	0.3	0.4	-0.5
Times rat made contact with spout	0.6	0.7	2.1	0.1	1.4	0.7	-0.4
Mean time between licks in bursts	0.8	1.1	1.4	-0.9	-1.1	-1.2	1.0
Mean num. licks in bursts	0.6	0.8	1.7	-1.3	1.1	0.0	0.5
Std. dev. time between licks in bursts	1.2	1.4	1.9	-1.3	-1.4	-0.9	1.1
Water consumed over 24 hours	3.8	4.4	7.0	1.7	2.6	2.1	-1.9
Indifference point 0 sec	2.0	3.2	4.4	1.3	1.8	2.1	-1.9
Indifference point AUC	3.0	3.6	3.9	2.0	1.9	1.8	-1.9
Indifference point function ln k	0.2	0.3	0.8	0.2	-0.3	0.9	-0.6
Indifference point function log k	0.2	0.3	0.8	0.2	-0.3	0.9	-0.6
Delay discounting total patch changes 0 sec	2.3	3.7	4.8	1.4	2.1	2.2	-2.0
Delay discounting total patch changes 12 sec	3.2	4.3	5.8	1.8	2.4	2.0	-2.0
Delay discounting total patch changes 18 sec	1.5	2.0	4.8	0.6	2.2	1.4	-0.9
Delay discounting total patch changes 24 sec	0.6	0.7	1.8	0.8	1.4	0.3	-0.5
Delay discounting total patch changes 6 sec	2.4	3.7	5.0	2.2	2.0	1.5	-1.9
Delay discounting time to switch 0 sec	8.4	12.9	16.9	-3.4	-2.6	-4.1	4.0
Delay discounting water rate 0 sec	14.7	23.3	28.6	4.5	4.0	5.3	-5.3
Delay discounting water rate 12 sec	9.5	14.3	19.8	4.5	2.5	3.7	-4.1
Delay discounting water rate 18 sec	3.6	4.8	6.5	2.0	1.6	2.4	-2.5
Delay discounting water rate 24 sec	3.3	4.5	6.4	2.1	1.5	2.2	-2.5
Delay discounting water rate 6 sec	3.2	4.6	6.5	2.0	1.4	2.5	-2.5
Locomotor activity	0.0	0.1	0.2	-0.3	0.4	0.1	-0.1
Locomotor testing distance	0.1	0.2	0.3	-0.6	0.6	0.4	-0.2
Locomotor testing rearing	2.0	3.1	5.6	-2.4	-0.8	-1.5	1.9
Light reinforcement 1	0.1	0.2	0.6	-0.3	0.8	-0.2	0.2
Light reinforcement 2	1.4	1.8	2.3	-1.5	-1.2	-1.3	1.4
Reaction time number correct	1.9	2.7	3.6	1.5	1.4	1.9	-1.7
Reaction time mean minus median	0.1	0.2	0.6	0.2	-0.8	-0.3	-0.0
Reaction time mean minus median AUC	0.2	0.3	1.1	-0.0	-1.0	-0.3	0.0
Reaction time num false alarms	0.6	0.8	1.6	0.6	1.3	0.9	-0.7
Reaction time num false alarms AUC	0.8	1.2	1.4	0.9	1.2	1.2	-1.1
Reaction time trials correct on left	1.9	2.7	3.6	1.5	1.4	1.9	-1.7
Reaction time trials on left	1.9	2.7	3.6	1.5	1.4	1.9	-1.7
Reaction time mean	0.7	1.0	1.9	-0.3	-1.4	-1.1	0.7
Reaction time mean AUC	0.5	0.7	1.8	-0.2	-1.4	-0.9	0.5
Median of all reaction times	0.5	0.7	1.2	-0.4	-1.1	-0.9	0.6
Reaction time omissions	1.3	1.8	3.4	1.8	0.3	1.0	-1.6
Reaction time false alarm rate	0.1	0.1	0.1	0.2	0.4	0.2	-0.3
Reaction time premature initiation rate	0.8	1.0	1.2	0.9	1.1	1.1	-1.0
Reaction time premature initiations	1.8	2.6	3.4	1.4	1.5	1.8	-1.6
Std. dev. reaction times	0.4	0.6	1.8	0.2	-1.4	-0.6	0.1
Reaction time trials completed	1.9	2.7	3.6	1.5	1.4	1.9	-1.7
Reaction time trials AUC	2.0	2.9	3.8	1.6	1.4	2.0	-1.8
Social response proportion	0.4	0.5	0.6	0.8	0.7	0.5	-0.7
Social responses	0.2	0.2	0.6	-0.8	0.5	-0.2	0.3
Social time	0.8	1.0	1.3	1.1	0.5	1.1	-1.2
Conditioned locomotion	0.6	0.7	1.6	0.1	0.6	1.3	-0.9
Cocaine response after cond. corrected	0.7	0.8	2.2	-0.2	-1.5	-0.7	0.6
Cocaine response after cond. not corrected	1.4	1.5	2.2	-0.6	-1.4	-1.5	1.2
Cocaine response before conditioning	1.7	2.1	3.3	-1.4	-0.2	-1.8	1.8
Saline control response	0.8	1.1	2.4	-1.5	-1.0	-0.5	0.9
Condit. Reinf. active minus inactive responses	0.6	0.8	1.5	1.2	0.8	0.7	-0.8
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.7	0.8	0.8	0.6	-0.7
Condit. Reinf. active responses	0.1	0.1	0.4	0.6	0.1	-0.1	-0.1
Condit. Reinf. inactive responses	0.6	0.7	1.0	-0.6	-1.0	-0.9	0.8
Condit. Reinf. lever presses	1.1	1.5	2.2	-0.9	-1.1	-1.5	1.3
Condit. Reinf. lever reinforcers received	0.0	0.1	0.2	0.5	0.1	-0.1	-0.1
Pavlov. Cond. lever latency	1.8	2.5	2.8	1.3	1.6	1.7	-1.7
Pavlov. Cond. magazine entry latency	4.0	4.5	6.4	-1.9	-1.6	-2.5	2.4
Pavlov. Cond. change in total contacts	3.5	4.9	6.1	-1.9	-2.0	-2.5	2.5
Pavlov. Cond. index score	3.8	5.0	7.0	-1.9	-1.7	-2.7	2.5
Pavlov. Cond. latency score	3.8	4.8	6.6	-1.9	-1.7	-2.6	2.5
Pavlov. Cond. lever contacts	2.3	3.2	4.4	-1.1	-2.1	-2.0	1.8
Pavlov. Cond. magazine entry number	3.1	3.8	5.5	1.6	1.4	2.4	-2.2
Pavlov. Cond. intertrial magazine entries	3.8	4.9	6.9	1.5	2.5	2.6	-2.1
Pavlov. Cond. lever-magazine prob. diff.	4.4	5.7	7.9	-2.1	-1.8	-2.8	2.7
Pavlov. Cond. response bias	3.0	4.2	5.7	-1.4	-2.1	-2.4	2.2
Conditioned reinforcement - actives	1.1	1.1	2.0	0.6	0.9	1.4	-1.2
Conditioned reinforcement - inactives	0.1	0.2	0.3	0.2	0.2	0.6	-0.5
Conditioned locomotion	1.1	1.4	2.6	-1.6	-0.8	-0.9	1.2
Intermittent access intake day 1-15 change	1.8	1.8	2.3	-1.5	-1.2	-1.1	1.5
Intermittent access intake escalation	2.0	1.9	2.5	-1.6	-1.2	-1.2	1.5
Intermittent access intake escalation 2	0.3	0.3	0.5	-0.7	-0.5	-0.2	0.5
Intermitt. access day 1 inactive lever presses	1.6	1.7	2.7	1.1	0.7	1.6	-1.5
Intermitt. access day 15 inactive lever presses	0.3	0.4	0.8	0.4	0.0	0.9	-0.7
Intermitt. access escalation Index	1.3	1.1	2.4	1.6	1.1	0.4	-0.9
Intermittent access day 1 total infusions	0.2	0.2	0.5	-0.3	-0.4	-0.7	0.5
Intermittent access day 15 total infusions	1.5	1.7	2.2	-1.2	-1.0	-1.5	1.5
Intermittent access terminal intake (last 3 days)	2.0	2.2	2.6	-1.2	-1.6	-1.6	1.5
Intermittent access total infusions	0.7	0.8	1.0	-0.8	-0.8	-1.0	0.9
Intermittent access day 1 locomotion	0.9	0.9	1.1	-0.9	-0.8	-1.0	1.0
Intermittent access day 15 total locomotion	0.4	0.4	0.6	-0.7	-0.4	-0.6	0.7
Intermittent access total locomotion	0.5	0.6	0.8	-0.9	-0.6	-0.7	0.8
Intermittent access standard deviation	3.4	3.6	4.4	-1.9	-1.6	-1.9	2.1
Cocaine induced anxiety	2.5	2.8	3.8	1.8	1.0	1.9	-2.0
Post-drug Anxiety	2.2	2.4	3.1	1.5	1.1	1.7	-1.8
Baseline Anxiety	1.2	1.2	1.7	-1.2	-0.3	-1.3	1.3
Lifetime Intake	0.4	0.5	0.6	-0.8	-0.5	-0.7	0.7
Incentive Sensitization - Responses	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.5	-0.2	-0.2	0.3
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	-0.7	-0.4	-0.4	0.5
Progressive ratio test 1 inactive lever presses	1.4	1.5	3.0	0.8	0.7	1.7	-1.4
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.8	0.8	0.3	0.9	-0.9
Total sessions with >9 infusions	0.4	0.4	1.0	-1.0	-0.2	-0.2	0.6
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.4
Short access day 10 total inactive lever presses	0.4	0.5	0.9	0.9	0.2	0.6	-0.8
Short access day 1 total infusions	0.3	0.3	0.6	0.4	0.8	0.4	-0.4
Short access day 10 total infusions	0.5	0.6	0.9	-0.9	-0.5	-0.8	0.8
Short access total infusions	0.3	0.3	0.5	-0.7	-0.3	-0.5	0.6
Short access day 1 locomotion	1.0	1.1	1.5	-1.2	-0.7	-1.0	1.1
Short access day 10 total locomotion	0.7	0.7	0.9	-0.9	-0.8	-0.9	0.9
Short access total locomotion	0.2	0.2	0.3	-0.5	-0.2	-0.3	0.5
Compulsive drug intake	0.0	0.0	0.0	0.0	-0.1	-0.2	0.0
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.1	-0.5	0.2	-0.1
One hour access (shock baseline)	0.1	0.1	0.2	-0.5	-0.4	-0.1	0.3
Number of responses in last shaping day	0.1	0.1	0.3	-0.1	-0.3	-0.5	0.2
Context. condit. distance diff. score	1.2	1.4	2.2	0.5	1.3	1.5	-1.2
Locomotion velocity, session 1	0.3	0.3	0.4	0.4	0.2	0.7	-0.7
Locomotion distance, session 1	0.1	0.2	0.3	-0.1	-0.5	-0.5	0.5
Locomotion velocity, session 2	0.1	0.1	0.3	-0.0	0.5	0.1	0.2
Locomotion distance, session 2	0.2	0.3	0.5	-0.1	-0.6	-0.7	0.6
Locomotion velocity, session 3	0.6	0.7	1.9	-1.4	0.2	-0.4	0.9
Locomotion distance, session 3	0.2	0.2	0.6	-0.8	-0.1	0.1	0.2
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.4	0.4	0.6	-0.4
Stereotopy head waving duration, day 3	0.3	0.3	0.5	0.5	0.5	0.7	-0.5
Locomotion velocity, session 7	1.4	1.6	4.1	-2.0	0.0	-0.7	1.3
Locomotion distance, session 7	1.6	2.0	4.0	-2.0	-0.7	-1.2	1.4
Stereotopy head waving bouts, day 7	0.5	0.5	1.2	0.1	0.7	1.1	-0.7
Stereotopy head waving duration, day 7	0.2	0.3	0.6	0.2	0.5	0.8	-0.4
Locomotion velocity, session 8	0.1	0.2	0.4	0.0	0.6	0.4	-0.2
Locomotion distance, session 8	0.1	0.1	0.4	-0.7	-0.1	-0.1	0.4
Degree of sensitization distance	0.1	0.2	0.2	-0.4	-0.1	-0.5	0.4
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.3	-0.0	0.5	-0.2
Condit. Reinf. active minus inactive responses	0.4	0.5	0.9	-0.4	-0.5	-0.9	0.7
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.9	-1.2	-1.2	-1.7	1.5
Condit. Reinf. active responses	0.2	0.2	0.4	-0.4	-0.2	-0.6	0.6
Condit. Reinf. inactive responses	1.4	1.7	2.3	1.2	1.2	1.5	-1.4
Incentive salience index mean	0.3	0.4	0.6	-0.4	-0.4	-0.8	0.7
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.4	0.2	-0.2	0.6
Time in familiar zone, hab. session 1	0.9	0.9	1.5	-1.1	-0.0	-0.8	1.2
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.5	-0.4	-0.2	-0.4
Total zone transitions, hab. session 1	0.5	0.8	1.0	-0.8	-0.7	-1.0	1.0
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.0
Locomotion velocity, hab. session 1	0.2	0.2	0.4	0.4	0.3	0.6	-0.5
Time in familiar zone, hab. session 2	1.0	1.1	1.9	-1.4	0.1	-0.9	1.2
Time in novel zone, hab. session 2	0.5	0.5	1.1	1.0	-0.7	-0.1	-0.6
Total zone transitions, hab. session 2	0.5	0.6	0.8	-0.5	-0.9	-0.9	0.8
Total locomotion distance, hab. session 2	0.3	0.4	0.7	0.7	-0.1	0.6	-0.8
Locomotion velocity, hab. session 2	0.3	0.5	0.7	0.7	0.1	0.8	-0.8
Novel to familiar place preference ratio	0.3	0.3	0.7	-0.4	-0.8	-0.5	0.3
Novelty place preference	0.2	0.2	0.4	-0.3	-0.6	-0.4	0.2
Time in novel zone, NPP test	0.2	0.2	0.4	-0.3	-0.6	-0.3	0.2
Total zone transitions, NPP test	0.1	0.1	0.3	0.4	-0.6	-0.3	0.1
Total locomotion distance, NPP test	0.1	0.1	0.4	0.1	-0.6	0.2	-0.3
Locomotion velocity, NPP test	0.1	0.1	0.3	0.2	-0.5	0.3	-0.4
Pavlov. Cond. lever latency	0.4	0.5	0.7	0.4	0.6	0.8	-0.8
Pavlov. Cond. magazine entry latency	0.8	1.0	2.1	-1.5	-0.4	-0.5	1.2
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	-0.5	0.1	-0.4	0.7
Pavlov. Cond. index score	0.7	0.9	1.2	-0.9	-0.9	-0.8	1.1
Pavlov. Cond. latency score	0.3	0.4	0.7	-0.5	-0.7	-0.6	0.8
Pavlov. Cond. lever contacts	0.5	0.6	1.0	-0.6	-0.6	-0.8	1.0
Pavlov. Cond. magazine entry number	1.0	1.3	1.8	1.3	0.9	0.9	-1.3
Pavlov. Cond. intertrial magazine entries	3.7	4.5	5.6	1.9	1.8	2.3	-2.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	0.9	-0.9	-0.8	-0.6	1.0
Pavlov. Cond. response bias	1.3	1.6	2.7	-1.6	-0.9	-0.9	1.5
Bone: apparent density	0.2	0.3	0.8	-0.9	-0.3	-0.2	0.5
Bone surface	0.1	0.1	0.2	-0.4	-0.5	-0.0	0.1
Bone volume	0.1	0.2	0.5	-0.7	-0.6	-0.1	0.3
Bone: connectivity density	0.0	0.1	0.2	-0.2	0.4	0.2	-0.1
Bone: cortical apparent density	7.0	9.1	11.4	2.5	2.9	3.4	-3.2
Bone: cortical area	0.6	0.8	1.9	0.2	-0.1	1.4	-1.2
Bone: cortical porosity	0.3	0.3	1.0	-1.0	-0.2	0.2	0.4
Bone: cortical porosity	0.7	0.8	1.5	-1.2	-0.9	-0.4	0.8
Bone: cortical thickness	0.4	0.7	2.0	-0.1	-0.1	1.4	-0.9
Bone: cortical thickness	0.3	0.3	0.8	-0.0	-0.2	0.9	-0.7
Bone: cortical tissue density	7.3	9.6	11.6	2.7	2.9	3.4	-3.2
Bone: elastic displacement	0.3	0.3	0.7	0.1	-0.2	0.9	-0.6
Bone: elastic work	0.1	0.2	0.4	-0.0	-0.7	0.5	-0.3
Bone: endosteal estimation	0.1	0.1	0.2	0.1	-0.4	-0.5	0.2
Bone: endosteal perimeter	0.1	0.2	0.3	0.6	-0.4	0.1	-0.5
Bone: final force	0.2	0.3	0.5	-0.4	-0.3	0.7	-0.6
Bone: final moment	0.2	0.3	0.7	-0.3	-0.4	0.8	-0.7
Bone: marrow area	0.0	0.1	0.2	0.2	-0.4	-0.4	0.1
Bone: maximum diameter	0.2	0.4	0.6	0.8	-0.4	0.4	-0.7
Bone: maximum force	0.2	0.3	0.7	-0.4	-0.2	0.8	-0.6
Bone: maximum moment	0.2	0.3	0.7	-0.4	-0.4	0.8	-0.6
Bone: minimum diameter	0.5	0.9	1.3	0.7	0.7	1.2	-1.1
Bone: periosteal estimation	0.2	0.4	0.7	0.6	-0.4	0.6	-0.8
Bone: periosteal perimeter	0.2	0.3	0.5	0.4	-0.6	0.4	-0.7
Bone: post-yield work	0.7	0.9	1.4	0.6	0.8	1.2	-1.1
Bone: stiffness	0.9	1.4	2.6	0.5	0.6	1.6	-1.5
Bone: tissue strength	0.1	0.1	0.1	-0.2	-0.0	0.3	-0.3
Bone: trabecular number	0.1	0.1	0.2	-0.4	0.5	0.1	0.1
Bone: trabecular spacing	0.2	0.3	0.9	0.3	-1.0	-0.2	0.0
Bone: trabecular thickness	0.1	0.1	0.2	0.3	0.4	0.4	-0.3
Bone: trabecular tissue density	0.4	0.5	1.8	-0.1	1.3	0.4	-0.2
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.4	0.4	0.0	0.1
Distance traveled before self-admin	0.1	0.1	0.2	0.5	-0.2	-0.3	-0.1
Distance traveled after self-admin	0.3	0.4	0.6	0.8	0.0	0.7	-0.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	-0.2	-0.7	-0.3	0.2
Delta time in open arm before/after self-admin	0.9	0.8	1.3	1.1	1.0	0.7	-0.9
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	-0.6	-0.7	0.2	0.2
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.3	-0.1	-0.0	0.1
Active lever presses in extinction session 6	1.1	1.1	1.3	0.9	1.0	1.1	-1.1
Delta distance traveled before/after self-admin	0.2	0.2	0.6	-0.8	-0.3	0.2	0.3
Delta ambulatory time before/after self-admin	0.3	0.3	0.7	-0.2	0.7	0.8	-0.4
Time in closed arm before self-admin	2.1	2.4	3.3	-1.3	-1.3	-1.8	1.7
Time in closed arm after self-admin	1.6	1.7	2.4	-1.0	-1.5	-1.4	1.2
Time in open arm before self-admin	4.3	4.5	5.5	2.2	1.6	2.3	-2.3
Time in open arm after self-admin	3.3	3.7	4.1	2.0	1.8	1.8	-2.0
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.0	-1.0	0.8	-0.4	0.7
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.1	1.0	0.9	0.8	-1.0
Time to tail flick, vehicle, after self-admin	0.4	0.4	1.0	-1.0	-0.3	-0.4	0.7
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.0	0.1	0.3	-0.2
Time to tail flick, test, after self-admin	1.3	1.4	1.8	1.1	1.0	1.3	-1.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.5	-1.2	-0.4	-0.3	0.7
Delta time to tail flick, test, before/after SA	0.8	0.7	1.0	0.8	0.7	0.9	-1.0
Ambulatory time before self-admin	0.3	0.3	1.0	0.4	-1.0	-0.4	-0.0
Ambulatory time after self-admin	0.0	0.0	0.1	-0.1	-0.4	-0.1	0.1
Total heroin consumption	1.1	1.3	1.9	0.6	1.4	1.3	-1.1
Area under the delay curve	0.2	0.2	0.3	0.5	0.6	-0.4	-0.0
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	0.5	0.7	0.1	-0.3
Delay disc. indifference point, 16s delay	0.3	0.3	0.9	0.6	1.0	-0.2	-0.1
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.3	-0.0	-0.3	0.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.6	-0.1	-0.2	-0.3
Delay disc. indifference point, 4s delay	0.5	0.5	1.0	1.0	0.8	0.0	-0.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.3	0.6	-0.7	0.2
Delay discount exponential model param	0.2	0.2	0.3	-0.6	-0.6	0.4	0.1
Delay discount hyperbolic model param	0.1	0.2	0.2	-0.5	-0.5	0.4	0.1
Fecal boli incidents, locomotor time 1	0.5	0.6	0.9	0.0	-0.9	-0.9	0.7
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.2	-0.0	0.0	-0.3
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.5	-0.4	-0.5	-0.7	0.6
Bouts of movement, locomotor time 1	0.7	0.7	1.0	-0.8	-1.0	-0.7	0.9
Total resting periods, locomotor time 1	0.8	0.8	1.1	-0.9	-1.1	-0.8	0.9
Rest time, locomotor task time 1	0.6	0.6	1.2	1.1	0.2	0.6	-0.9
Distance moved, locomotor task time 1	0.9	1.0	2.1	-1.5	-0.2	-0.8	1.1
Vertical activity count, locomotor time 1	0.4	0.4	1.0	-0.0	1.0	0.6	-0.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.7	0.0	0.0	0.9	-0.5
Bouts of movement, locomotor time 2	2.2	2.4	3.3	1.8	0.5	1.7	-1.8
Total resting periods, locomotor time 2	1.9	2.1	3.2	1.8	0.5	1.4	-1.7
Rest time, locomotor task time 2	0.7	0.8	1.8	1.4	-0.1	0.6	-1.0
Distance moved, locomotor task time 2	0.9	1.1	2.7	-1.6	0.0	-0.6	1.2
Vertical activity count, locomotor time 2	0.3	0.3	0.6	-0.6	0.5	0.8	-0.1
Weight adjusted by age	0.0	0.0	0.0	0.2	-0.0	0.2	-0.2
Seeking ratio, delayed vs. immediate footshock	1.0	1.1	2.3	0.9	1.5	1.0	-0.7
Locomotion in novel chamber	4.9	6.0	8.5	2.9	1.3	2.5	-2.8
Locomotion in novel chamber post-restriction	0.2	0.2	0.4	0.6	-0.7	-0.0	-0.2
Progressive ratio	0.6	0.7	1.0	0.9	1.0	0.6	-0.8
Food seeking constrained by brief footshock	0.9	1.1	1.8	0.6	0.8	1.3	-1.3
Seeking ratio, punishment vs. effort	0.2	0.2	0.7	-0.8	-0.4	0.2	0.1
Run reversals in cocaine runway, females	0.9	0.9	1.3	-0.9	-0.5	-1.1	1.1
Run reversals in cocaine runway, males	0.8	0.8	2.0	0.4	0.5	1.4	-0.8
Latency to leave start box in cocaine runway	0.2	0.2	0.3	-0.5	0.3	-0.2	0.6
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.5	0.5	-0.2	0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	-0.3	-0.1	0.4
Cd content in liver	1.1	1.2	3.2	1.8	-0.2	0.3	-1.1
Co content in liver	0.6	0.7	1.0	0.8	0.1	1.0	-1.0
Cu content in liver	0.7	0.8	1.6	-0.2	-0.9	-1.3	0.8
Fe content in liver	0.1	0.1	0.3	-0.4	-0.1	-0.5	0.3
K content in liver	0.1	0.1	0.2	0.1	0.5	0.5	-0.2
Mg content in liver	0.2	0.2	0.4	0.2	0.7	0.6	-0.2
Mn content in liver	0.4	0.5	1.2	-1.1	0.4	0.4	0.5
Na content in liver	0.0	0.0	0.0	-0.1	0.2	0.1	0.1
Rb content in liver	0.5	0.6	0.9	0.6	0.9	0.8	-0.9
Se content in liver	0.3	0.4	1.1	1.0	-0.5	-0.1	-0.4
Sr content in liver	0.5	0.5	1.0	1.0	-0.1	0.4	-0.9
Zn content in liver	0.5	0.6	1.3	1.1	0.1	0.6	-0.8