Hub : Traits : Extensor digitorum longus weight : ← →

chr7:127,692,699-129,997,098

Trait: Extensor digitorum longus weight

Best TWAS P=7.53926e-08 · Best GWAS P=1.115298e-07 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Rpap3	mRNA stability	ENSRNOG00000053405	0.04	0.02	blup	2213	0.03	2.7e-04	4.9	-5.1	3.3e-07	-1.00	0.65	0.33	FALSE
2	Adipose	Hdac7	mRNA stability	ENSRNOG00000055597	0.18	0.16	enet	238	0.17	5.4e-18	4.6	-5.4	7.9e-08	-0.87	0.65	0.35	FALSE
3	BLA	Pced1b	alternative TSS	ENSRNOT00000009199	0.06	0.07	top1	1	0.07	1.9e-04	5.2	5.2	2.3e-07	0.98	0.11	0.05	FALSE
4	BLA	Tmem106c	gene expression	ENSRNOG00000053269	0.24	0.30	lasso	22	0.30	1.3e-16	5.2	5.3	1.4e-07	0.99	0.61	0.39	FALSE
5	BLA	Rpap3	gene expression	ENSRNOG00000053405	0.57	0.35	enet	156	0.39	3.7e-22	5.2	-5.2	2.3e-07	-1.00	0.62	0.38	FALSE
6	BLA	Tmem106c	intron excision ratio	chr7:129089299:129091145	0.10	0.09	top1	1	0.09	1.9e-05	5.2	-5.2	2.3e-07	-0.99	0.15	0.10	FALSE
7	Brain	Slc48a1	gene expression	ENSRNOG00000053196	0.46	0.58	lasso	70	0.59	1.6e-67	5.1	5.1	2.8e-07	1.00	0.60	0.40	FALSE
8	Brain	Rpap3	gene expression	ENSRNOG00000053405	0.17	0.18	lasso	39	0.19	4.4e-17	5.2	-5.2	2.4e-07	-1.00	0.62	0.38	FALSE
9	Brain	Tmem106c	intron excision ratio	chr7:129089299:129091145	0.12	0.04	top1	1	0.04	1.9e-04	5.2	-5.2	2.2e-07	-1.00	0.10	0.06	FALSE
10	Brain	Tmem106c	intron excision ratio	chr7:129091535:129091915	0.03	0.03	top1	1	0.03	5.8e-04	5.2	5.2	2.2e-07	0.99	0.08	0.04	FALSE
11	IL	Slc48a1	gene expression	ENSRNOG00000053196	0.33	0.28	lasso	4	0.28	1.6e-07	5.0	5.1	3.0e-07	1.00	0.65	0.35	FALSE
12	LHb	Rapgef3	alternative TSS	ENSRNOT00000078644	0.35	0.25	top1	1	0.25	1.1e-06	5.2	-5.2	2.1e-07	-1.00	0.24	0.15	FALSE
13	LHb	Rapgef3	alternative TSS	ENSRNOT00000096691	0.53	0.20	blup	2378	0.25	1.3e-06	5.2	5.1	2.8e-07	0.99	0.65	0.34	FALSE
14	LHb	Slc48a1	gene expression	ENSRNOG00000053196	0.57	0.18	blup	2371	0.22	6.1e-06	5.2	5.4	7.5e-08	0.99	0.64	0.35	TRUE
15	LHb	Rapgef3	gene expression	ENSRNOG00000059961	0.33	0.11	blup	2378	0.14	2.7e-04	5.2	5.2	1.6e-07	0.99	0.62	0.32	FALSE
16	LHb	Rapgef3	isoform ratio	ENSRNOT00000096691	0.17	0.15	enet	73	0.16	1.5e-04	5.2	5.1	2.9e-07	-0.23	0.60	0.32	TRUE
17	LHb	Rapgef3	intron excision ratio	chr7:128879272:128880061	0.14	0.09	enet	14	0.13	7.1e-04	5.2	-5.2	2.1e-07	-1.00	0.58	0.29	FALSE
18	Liver	Rpap3	gene expression	ENSRNOG00000053405	0.49	0.43	blup	2213	0.45	2.6e-55	4.8	-5.1	2.8e-07	-1.00	0.63	0.37	FALSE
19	Liver	Rpap3	mRNA stability	ENSRNOG00000053405	0.08	0.05	blup	2213	0.06	1.5e-07	5.0	-5.1	3.3e-07	-1.00	0.66	0.34	FALSE
20	Liver	Pfkm	mRNA stability	ENSRNOG00000057988	0.15	0.13	top1	1	0.13	5.3e-14	5.2	-5.2	1.6e-07	-0.99	0.36	0.64	FALSE
21	NAcc	Slc48a1	gene expression	ENSRNOG00000053196	0.39	0.24	blup	2372	0.26	1.1e-19	5.2	5.2	2.1e-07	1.00	0.63	0.37	FALSE
22	NAcc	Tmem106c	gene expression	ENSRNOG00000053269	0.34	0.30	enet	46	0.30	4.7e-23	5.2	5.2	2.3e-07	1.00	0.57	0.43	FALSE
23	OFC	Rapgef3	alternative TSS	ENSRNOT00000096691	0.20	0.13	blup	2378	0.16	1.1e-04	5.3	5.1	2.8e-07	1.00	0.63	0.33	FALSE
24	OFC	Tmem106c	gene expression	ENSRNOG00000053269	0.22	0.18	top1	1	0.18	4.7e-05	5.2	5.2	2.2e-07	0.99	0.16	0.10	FALSE
25	OFC	Rpap3	gene expression	ENSRNOG00000053405	0.31	0.16	blup	2213	0.17	6.8e-05	5.0	-5.1	3.0e-07	-1.00	0.64	0.34	FALSE
26	OFC	Hdac7	isoform ratio	ENSRNOT00000118593	0.12	0.15	top1	1	0.15	1.7e-04	5.2	5.2	2.3e-07	1.00	0.12	0.05	FALSE
27	OFC	Tmem106c	intron excision ratio	chr7:129091964:129092334	0.33	0.12	top1	1	0.12	8.8e-04	5.2	-5.2	2.1e-07	-0.99	0.12	0.06	FALSE
28	PL	Rpap3	alternative TSS	ENSRNOT00000083926	0.05	0.03	blup	2212	0.03	3.6e-03	5.2	5.1	3.3e-07	1.00	0.63	0.33	FALSE
29	PL	Rpap3	alternative TSS	ENSRNOT00000106326	0.05	0.03	blup	2212	0.03	2.9e-03	5.2	-5.1	3.2e-07	-1.00	0.64	0.34	FALSE
30	PL	Rpap3	alternative TSS	ENSRNOT00000083926	0.05	0.02	blup	2212	0.03	4.5e-03	5.2	5.1	3.2e-07	1.00	0.63	0.33	FALSE
31	PL	Rpap3	alternative TSS	ENSRNOT00000106326	0.05	0.02	top1	1	0.03	5.1e-03	5.2	-5.2	1.8e-07	-1.00	0.08	0.04	FALSE
32	PL	Asb8	gene expression	ENSRNOG00000010099	0.03	0.02	top1	1	0.02	9.5e-03	5.2	-5.2	2.3e-07	-0.99	0.07	0.04	FALSE
33	PL	Slc48a1	gene expression	ENSRNOG00000053196	0.29	0.35	top1	1	0.35	2.5e-27	5.2	5.2	2.2e-07	1.00	0.59	0.41	FALSE
34	PL	Tmem106c	gene expression	ENSRNOG00000053269	0.47	0.38	lasso	17	0.39	2.9e-31	5.2	5.2	2.2e-07	0.99	0.56	0.44	FALSE
35	PL	Rapgef3	isoform ratio	ENSRNOT00000096691	0.09	0.11	top1	1	0.11	1.8e-08	5.2	5.2	2.3e-07	1.00	0.59	0.40	FALSE
36	PL	Tmem106c	intron excision ratio	chr7:129091535:129091915	0.11	0.09	top1	1	0.09	1.3e-07	5.2	5.2	2.2e-07	0.99	0.49	0.45	FALSE
37	PL	Tmem106c	mRNA stability	ENSRNOG00000053269	0.11	0.12	top1	1	0.12	1.4e-09	5.2	5.2	2.1e-07	0.99	0.51	0.49	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.