Hub : Genes

Stxbp2

Models

#	tissue	modality	RNA phenotype	h²	h² se	h² P	eQTL R²	BLUP R²	ENET R²	LASSO R²	eQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000000994	0.0650	0.0400	1.3e-04	0.029	0.030	0.035	0.035	3.0e-04	2.3e-04	8.2e-05	8.7e-05
2	Adipose	isoform ratio	ENSRNOT00000001322	0.0370	0.0250	8.7e-03	0.007	0.009	0.010	0.007	4.9e-02	3.3e-02	2.3e-02	4.6e-02
3	Adipose	isoform ratio	ENSRNOT00000107607	0.0890	0.0480	8.6e-06	0.037	0.025	0.027	0.032	5.6e-05	7.0e-04	4.8e-04	1.5e-04
4	BLA	gene expression	ENSRNOG00000000994	0.1941	0.0921	1.1e-05	0.132	0.122	0.085	0.124	1.6e-07	4.8e-07	2.6e-05	3.7e-07
5	BLA	isoform ratio	ENSRNOT00000107607	0.0660	0.0480	6.7e-03	0.009	0.034	0.020	0.017	9.9e-02	6.1e-03	3.0e-02	4.2e-02
6	Brain	gene expression	ENSRNOG00000000994	0.1000	0.0600	8.8e-04	0.042	0.033	0.035	0.042	8.7e-05	4.6e-04	3.4e-04	8.8e-05
7	Liver	alternative polyA	ENSRNOT00000001322	0.0373	0.0230	1.0e-03	0.008	0.022	0.019	0.015	3.5e-02	1.6e-03	2.8e-03	6.9e-03
8	Liver	alternative polyA	ENSRNOT00000107607	0.0369	0.0229	1.2e-03	0.008	0.021	0.018	0.015	3.6e-02	1.9e-03	3.6e-03	7.6e-03
9	Liver	isoform ratio	ENSRNOT00000107607	0.1540	0.0698	8.7e-11	0.086	0.081	0.084	0.088	7.7e-10	2.4e-09	1.4e-09	5.9e-10
10	Liver	isoform ratio	ENSRNOT00000115749	0.0973	0.0510	3.3e-06	0.046	0.028	0.031	0.039	6.9e-06	3.5e-04	1.9e-04	3.4e-05
11	NAcc	gene expression	ENSRNOG00000000994	0.0980	0.0580	1.7e-03	0.067	0.046	0.061	0.061	9.6e-06	2.2e-04	2.4e-05	2.7e-05
12	NAcc	isoform ratio	ENSRNOT00000107607	0.0786	0.0457	2.2e-04	0.054	0.049	0.035	0.041	6.7e-05	1.5e-04	1.2e-03	4.8e-04
13	OFC	gene expression	ENSRNOG00000000994	0.4329	0.1587	2.0e-03	0.144	0.140	0.142	0.125	2.8e-04	3.3e-04	3.1e-04	7.0e-04
14	PL	gene expression	ENSRNOG00000000994	0.1290	0.0544	1.0e-05	0.048	0.059	0.046	0.053	1.6e-04	2.6e-05	1.9e-04	7.1e-05
15	PL	isoform ratio	ENSRNOT00000107607	0.0750	0.0470	3.1e-03	0.061	0.035	0.046	0.021	2.2e-05	1.1e-03	2.1e-04	9.0e-03

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method.

Trait associations

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15
Length with tail	12.1	44.4	76.1	-3.4	6.0	-7.5	-7.7	-3.1	-6.5	-3.3	3.4	-8.5	7.6	-8.7	-6.8	-8.7	-8.0	-6.1
Body weight	11.8	50.0	86.3	-3.3	6.7	-8.1	-8.0	-4.0	-5.9	-3.3	3.4	-9.3	7.9	-9.2	-7.0	-9.2	-8.8	-7.0
Length without tail	8.3	18.0	32.0	-2.2	4.3	-4.8	-4.8	-2.6	-3.5	-1.8	1.9	-5.4	4.6	-5.7	-3.6	-5.6	-5.4	-4.3
Tail length	6.3	19.1	30.9	-1.5	3.3	-5.0	-5.1	-2.2	-4.6	-2.8	2.8	-5.6	5.2	-5.2	-5.1	-5.2	-5.1	-4.1
Tibialis anterior weight	6.3	21.7	33.8	-1.7	4.1	-5.0	-5.3	-3.5	-4.6	-3.0	3.0	-5.7	5.2	-5.3	-5.1	-5.4	-5.8	-5.0
Left kidney weight	6.1	17.4	34.3	-2.9	3.0	-4.6	-4.6	-1.4	-4.5	-1.8	1.9	-5.4	4.5	-5.9	-4.0	-5.8	-4.9	-3.7
Social response proportion	5.8	6.3	10.3	0.8	1.8	-3.0	-3.1	-1.4	-3.2	-2.6	2.6	-2.9	3.2	-2.3	-3.0	-2.2	-2.7	-1.0
Right kidney weight	5.3	15.1	30.9	-2.7	3.1	-4.4	-4.3	-1.2	-3.7	-1.5	1.5	-5.3	4.1	-5.6	-3.8	-5.5	-4.6	-3.2
Context. condit. distance diff. score	4.4	5.3	8.7	-0.3	2.0	-2.5	-2.5	-2.5	-2.6	-2.0	2.0	-2.5	2.4	-2.0	-2.4	-2.0	-2.8	-3.0
Extensor digitorum longus weight	4.2	16.9	26.7	-2.1	3.3	-4.3	-4.6	-3.0	-4.2	-2.4	2.5	-5.0	4.4	-4.8	-4.3	-4.9	-5.2	-4.7
Bone: connectivity density	4.1	6.5	13.3	-3.0	2.8	-2.6	-2.2	-0.9	-1.9	-0.2	0.2	-3.4	2.2	-3.6	-2.2	-3.7	-3.0	-2.9
Bone: trabecular thickness	4.1	4.9	9.9	-2.0	2.8	-2.2	-1.9	-1.6	-1.6	-0.6	0.6	-2.7	1.9	-2.8	-2.0	-2.8	-2.7	-3.1
Bone surface	4.0	7.1	13.5	-2.6	3.4	-2.6	-2.3	-1.4	-1.5	-0.3	0.3	-3.3	2.3	-3.6	-2.4	-3.7	-3.2	-3.5
Reaction time mean minus median	3.7	4.8	10.8	2.4	0.1	-2.0	-2.2	-3.3	-2.2	-3.2	3.2	-1.2	2.2	-0.0	-2.6	-0.1	-1.9	-2.3
BMI without tail	3.6	7.5	12.7	-0.2	2.3	-3.2	-3.1	-1.8	-2.5	-2.1	2.1	-3.6	3.4	-3.0	-3.4	-2.9	-3.2	-2.6
Se content in liver	3.6	4.3	13.2	0.9	2.5	-2.1	-1.8	-3.0	-1.5	-2.0	2.0	-1.9	1.8	-1.0	-1.6	-1.0	-2.3	-3.6
Cd content in liver	3.5	3.8	6.1	-0.2	-2.5	2.2	2.1	1.7	1.1	1.2	-1.2	2.2	-2.3	2.1	2.3	2.1	2.3	2.3
Seeking ratio, delayed vs. immediate footshock	3.3	3.8	5.3	-0.3	-1.3	2.2	2.2	2.2	2.0	1.9	-2.0	2.1	-2.3	1.5	2.1	1.5	2.3	2.3
Compulsive drug intake	3.1	3.1	5.0	0.8	-1.6	1.8	2.0	1.3	1.4	1.0	-1.1	2.1	-2.1	2.0	1.9	2.1	2.2	2.2
Tibia length	3.0	8.5	19.9	-1.8	3.3	-3.1	-3.3	-0.1	-1.8	-0.7	0.7	-3.9	3.4	-4.4	-3.2	-4.5	-3.3	-1.3
Bone: cortical area	3.0	4.6	6.7	0.1	2.3	-2.3	-2.5	-2.1	-2.0	-1.8	1.8	-2.4	2.4	-2.0	-2.4	-2.0	-2.6	-2.4
Bone: trabecular number	2.9	4.6	9.2	-2.4	2.9	-2.1	-1.8	-0.9	-1.4	-0.1	0.1	-2.8	1.8	-3.0	-1.8	-3.0	-2.5	-2.3
Bone: trabecular tissue density	2.9	4.1	9.9	3.0	0.7	-1.8	-2.0	-2.6	-2.2	-3.1	3.1	-1.1	2.1	0.2	-2.1	0.2	-1.5	-1.1
Condit. Reinf. active responses	2.7	3.7	7.0	0.9	0.4	-2.4	-2.3	-2.0	-2.6	-2.4	2.4	-1.9	2.1	-0.9	-2.1	-1.0	-2.0	-1.8
Conditioned reinforcement - actives	2.7	2.7	5.1	-0.8	1.6	-1.9	-2.0	-0.1	-2.3	-1.0	1.0	-2.0	2.1	-1.5	-1.7	-2.0	-1.7	-1.1
Bone: apparent density	2.7	4.5	11.3	-3.4	2.8	-1.7	-1.3	-0.7	-0.9	0.6	-0.6	-2.5	1.2	-3.1	-1.3	-3.1	-2.3	-2.8
Food seeking constrained by brief footshock	2.7	3.2	5.4	-1.4	-0.2	2.3	2.3	1.6	2.3	2.3	-2.3	1.8	-2.1	0.8	2.2	0.9	1.8	0.8
BMI with tail	2.5	8.1	13.5	-0.2	2.7	-3.2	-3.1	-2.7	-1.8	-1.9	1.9	-3.6	3.1	-3.2	-3.0	-3.1	-3.7	-3.3
Bone volume	2.5	4.2	10.6	-2.7	3.3	-1.5	-1.3	-1.1	-0.6	0.4	-0.4	-2.3	1.3	-2.8	-1.4	-2.8	-2.3	-3.1
Bone: trabecular spacing	2.5	3.2	5.9	1.2	-2.0	2.0	1.9	0.7	1.7	0.7	-0.7	2.4	-1.9	2.3	1.8	2.4	2.1	1.6
Bone: cortical thickness	2.4	4.0	6.1	0.0	2.5	-2.1	-2.3	-1.7	-1.8	-1.6	1.6	-2.3	2.3	-2.0	-2.3	-2.0	-2.4	-2.0
Bone: final force	2.4	3.9	6.2	-0.5	2.0	-2.2	-2.4	-0.8	-2.0	-1.2	1.2	-2.5	2.3	-2.4	-2.4	-2.4	-2.2	-1.1
Condit. Reinf. active minus inactive responses	2.3	2.8	6.0	1.0	0.1	-2.2	-2.1	-1.3	-2.5	-2.1	2.1	-1.8	1.9	-0.9	-1.9	-1.0	-1.6	-0.7
Bone: elastic work	2.3	3.0	6.6	-1.9	1.9	-1.7	-1.7	-0.6	-1.5	-0.3	0.4	-2.2	1.6	-2.5	-1.6	-2.6	-2.1	-1.5
Delay disc. indifference point, 0s delay	2.3	2.5	4.5	2.1	1.7	-1.7	-1.9	-1.6	-0.7	-1.9	1.9	-1.4	2.1	-0.6	-2.1	-0.4	-1.5	-0.3
Liver weight, right	2.2	3.6	7.5	-2.2	1.7	-1.8	-1.6	-0.8	-1.5	-0.3	0.4	-2.3	1.8	-2.7	-1.2	-2.7	-2.3	-2.6
Condit. Reinf. lever reinforcers received	2.1	3.0	6.3	1.1	0.0	-2.1	-2.0	-1.8	-2.5	-2.3	2.4	-1.6	1.8	-0.5	-1.8	-0.6	-1.6	-1.4
Fe content in liver	2.1	2.5	8.7	-0.6	1.4	-1.2	-1.4	-2.0	-1.8	-1.3	1.4	-1.4	1.3	-1.2	-1.3	-1.2	-1.9	-2.9
Bone: final moment	1.9	3.1	5.1	-0.6	1.9	-2.0	-2.1	-0.5	-1.8	-1.0	1.0	-2.3	2.0	-2.2	-2.1	-2.3	-2.0	-0.9
Time >=10cm from walls, locomotor time 2	1.9	2.0	4.0	0.7	1.5	-1.7	-1.5	-2.0	-0.7	-1.3	1.3	-1.4	1.7	-0.9	-1.6	-0.8	-1.8	-1.6
Bone: maximum force	1.7	3.0	5.1	-1.1	2.0	-1.8	-1.9	-0.7	-1.8	-0.8	0.8	-2.2	1.9	-2.2	-1.9	-2.3	-2.0	-1.6
Total heroin consumption	1.7	2.0	6.0	2.1	-1.8	1.0	1.0	-1.4	0.4	-1.0	1.0	1.6	-1.1	2.5	0.9	2.3	0.9	-0.1
Delay disc. indifference point, 2s delay	1.7	1.9	8.2	2.9	-0.5	-0.3	-0.5	-2.3	-0.0	-2.0	2.0	0.4	0.8	1.4	-0.7	1.7	-0.4	-0.7
Median of all reaction times	1.6	2.1	8.6	2.9	-0.7	1.0	0.9	-0.4	1.3	-0.6	0.6	1.7	-0.8	2.3	0.8	2.3	1.4	1.5
Condit. Reinf. active-inactive response ratio	1.6	1.7	3.7	1.5	-0.4	-1.6	-1.5	-0.8	-1.9	-1.9	1.9	-1.1	1.4	-0.2	-1.4	-0.3	-0.9	0.2
Conditioned locomotion	1.6	1.9	4.2	-0.9	1.2	-1.4	-1.6	-0.7	-2.0	-1.0	1.0	-1.4	1.9	-1.1	-1.3	-1.4	-1.5	-1.7
Delta time in open arm before/after self-admin	1.6	1.6	2.9	0.6	-1.7	1.3	1.3	-0.0	1.6	0.6	-0.7	1.5	-1.7	1.5	1.5	1.4	1.1	0.8
Zn content in liver	1.6	1.7	5.3	-2.3	1.5	-0.8	-0.8	0.6	-0.5	0.8	-0.8	-1.6	0.7	-2.2	-0.8	-2.2	-1.2	-0.6
Mean time between licks in bursts	1.5	2.1	3.3	0.4	-1.3	1.6	1.8	0.8	1.3	0.9	-0.9	1.8	-1.7	1.7	1.6	1.8	1.7	1.2
Locomotor activity	1.5	2.4	6.7	-0.1	0.7	-1.9	-1.7	-1.0	-2.6	-1.8	1.8	-1.8	1.9	-1.3	-1.2	-1.2	-1.7	-1.2
Std. dev. reaction times	1.5	2.1	6.3	2.5	-0.3	-0.8	-1.1	-2.3	-0.9	-2.3	2.2	-0.1	1.1	0.8	-1.4	0.7	-0.8	-1.1
Social responses	1.5	1.9	5.0	-0.5	0.9	-1.4	-1.5	-1.0	-2.2	-1.4	1.4	-1.5	1.5	-1.3	-1.1	-1.3	-1.5	-1.4
Social time	1.5	2.0	5.2	1.9	-1.4	1.3	1.1	0.2	0.5	-0.5	0.5	1.8	-1.0	2.1	0.6	2.3	1.5	1.9
Intermittent access day 1 locomotion	1.5	1.6	5.9	1.6	-1.5	0.9	0.8	-1.2	0.3	-0.8	0.8	1.5	-0.8	2.4	0.8	2.0	0.8	-0.5
Breakpoint value in progressive ratio session	1.5	1.7	4.1	1.3	0.2	-1.1	-1.2	-2.0	-1.3	-1.8	1.8	-0.8	1.3	-0.1	-1.2	-0.2	-1.3	-1.8
Delay discounting total patch changes 0 sec	1.4	2.2	5.9	-2.4	-0.2	1.5	1.7	1.5	1.4	2.2	-2.2	1.0	-1.7	0.0	1.9	0.0	1.0	-0.1
Post-drug Anxiety	1.4	1.5	6.5	2.5	-1.2	0.5	0.6	-1.2	0.5	-0.9	0.9	1.2	-0.4	2.1	0.3	2.1	0.8	0.1
Locomotion distance, session 2	1.4	1.9	4.3	0.9	-2.1	1.4	1.4	1.0	0.5	0.2	-0.2	1.6	-1.4	1.9	1.4	2.0	1.8	1.4
Pavlov. Cond. lever latency	1.4	1.8	5.4	-1.6	0.3	-1.6	-1.3	0.3	-1.0	0.1	-0.1	-1.7	1.2	-2.2	-1.3	-2.3	-1.4	-0.6
Bone: maximum diameter	1.4	2.5	4.5	-1.2	2.1	-1.4	-1.6	-1.0	-1.2	-0.5	0.6	-1.8	1.5	-2.0	-1.5	-2.0	-1.9	-2.0
Delay discount exponential model param	1.4	1.5	6.5	-2.6	0.8	0.5	0.6	1.6	0.4	1.9	-1.9	-0.2	-0.7	-1.2	0.6	-1.3	0.2	-0.1
Locomotion in novel chamber post-restriction	1.4	1.6	4.7	-0.6	-0.5	-1.3	-1.4	-0.6	-2.2	-1.1	1.2	-1.3	1.6	-1.3	-1.1	-1.3	-1.3	-1.4
Rb content in liver	1.4	1.8	5.1	0.7	-2.3	1.2	1.5	-0.2	1.1	0.5	-0.5	1.7	-1.5	1.7	1.7	1.7	1.2	-0.3
Stereotopy head waving bouts, day 3	1.3	1.5	4.9	-1.6	0.8	-1.0	-1.1	-0.2	-0.6	0.1	-0.1	-1.5	1.2	-2.2	-1.2	-2.1	-1.4	-0.8
Locomotion distance, session 8	1.3	1.9	2.7	0.2	1.3	-1.6	-1.6	-1.3	-1.6	-1.4	1.4	-1.6	1.5	-1.0	-1.5	-1.1	-1.6	-1.3
Bone: maximum moment	1.3	2.3	4.4	-1.2	1.8	-1.5	-1.6	-0.5	-1.5	-0.5	0.5	-1.9	1.6	-2.0	-1.6	-2.1	-1.7	-1.3
Bone: periosteal estimation	1.3	2.6	4.4	-1.3	1.8	-1.6	-1.7	-0.8	-1.6	-0.7	0.7	-1.9	1.6	-2.1	-1.6	-2.1	-1.9	-1.7
Bone: periosteal perimeter	1.3	2.2	5.6	-0.1	1.0	-1.4	-1.5	-1.9	-1.8	-1.5	1.5	-1.3	1.4	-0.9	-1.4	-0.9	-1.7	-2.4
Area under the delay curve	1.3	1.4	6.5	2.5	-0.5	-0.6	-0.7	-1.5	-0.4	-1.9	1.9	0.0	0.9	1.0	-0.8	1.1	-0.3	0.2
Delay discount hyperbolic model param	1.3	1.4	6.4	-2.5	0.7	0.4	0.5	1.6	0.3	1.8	-1.8	-0.3	-0.7	-1.2	0.6	-1.4	0.2	-0.1
Delay discounting total patch changes 18 sec	1.2	1.6	5.2	-2.3	-0.0	0.9	1.2	1.5	1.0	2.0	-2.0	0.4	-1.3	-0.4	1.6	-0.4	0.7	0.1
Reaction time mean AUC	1.2	1.6	8.7	2.9	-0.6	0.4	0.2	-1.2	0.5	-1.3	1.3	1.1	-0.2	1.9	0.1	1.9	0.7	0.5
Pavlov. Cond. response bias	1.2	1.7	4.3	2.1	-1.3	-0.7	-0.6	-2.0	-1.2	-1.9	1.9	0.2	0.4	1.4	-0.4	1.4	-0.3	-1.1
Intermittent access total locomotion	1.2	1.4	5.7	1.5	-1.2	0.8	0.6	-1.1	-0.3	-1.1	1.1	1.3	-0.4	2.4	0.7	1.9	0.7	-0.3
Time in familiar zone, hab. session 1	1.2	1.1	2.5	-0.9	0.6	1.4	1.2	1.0	1.6	1.5	-1.5	0.9	-1.0	0.1	1.0	0.2	0.8	0.4
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.1	-0.0	-1.2	1.3	1.4	0.9	1.0	0.8	-0.8	1.4	-1.4	1.3	1.4	1.4	1.5	1.1
Bone: tissue strength	1.2	1.2	2.8	-1.5	-0.1	1.0	1.0	1.4	1.2	1.7	-1.7	0.5	-1.1	-0.1	1.1	-0.2	0.8	0.8
Reaction time mean	1.1	1.6	9.4	3.1	-0.5	0.3	0.0	-1.2	0.4	-1.4	1.4	1.0	-0.0	1.8	-0.1	1.8	0.6	0.6
Pavlov. Cond. lever latency	1.1	1.4	3.5	-1.7	1.0	1.1	1.0	1.7	1.5	1.9	-1.9	0.4	-0.7	-0.7	0.8	-0.7	0.6	1.0
Pavlov. Cond. magazine entry latency	1.1	1.2	5.6	2.4	-0.6	-0.4	-0.4	-1.6	-0.4	-1.6	1.6	0.4	0.3	1.4	-0.3	1.4	-0.0	-0.6
Baseline Anxiety	1.1	1.2	5.4	2.3	-1.1	0.4	0.6	0.0	1.2	-0.2	0.1	0.9	-0.5	1.5	0.3	1.4	1.0	1.7
Sr content in liver	1.1	1.0	3.2	-1.6	-0.2	0.7	0.5	1.8	0.9	1.6	-1.6	0.2	-0.6	-0.6	0.2	-0.6	0.6	1.3
Water consumed over 24 hours	1.0	1.2	3.9	-1.6	0.8	-0.9	-1.0	0.7	-1.0	0.1	-0.1	-1.4	0.8	-1.9	-0.8	-2.0	-1.0	0.1
Indifference point 0 sec	1.0	1.6	4.6	-2.1	0.2	1.2	1.4	1.2	1.3	1.9	-1.9	0.7	-1.3	-0.2	1.5	-0.1	0.8	-0.2
Delay discounting total patch changes 24 sec	1.0	1.3	2.9	-1.7	-0.7	1.4	1.5	0.8	0.6	1.2	-1.2	1.2	-1.5	0.5	1.4	0.6	0.9	-0.5
Reaction time mean minus median AUC	1.0	1.2	3.1	1.7	-1.2	-0.3	-0.5	-1.7	-1.0	-1.8	1.7	0.3	0.5	1.0	-1.0	0.9	-0.3	-0.9
Pavlov. Cond. index score	1.0	1.2	3.9	2.0	-1.2	-0.5	-0.4	-1.5	-1.0	-1.7	1.7	0.3	0.2	1.4	-0.3	1.3	-0.1	-0.5
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	4.3	2.1	-1.2	-0.4	-0.4	-1.4	-1.0	-1.7	1.7	0.4	0.2	1.5	-0.2	1.4	0.0	-0.4
Short access day 10 total inactive lever presses	1.0	1.1	5.4	-2.3	1.2	-0.1	-0.1	0.9	0.2	1.1	-1.1	-0.9	0.6	-1.6	-0.0	-1.7	-0.6	-0.3
Short access day 1 total infusions	1.0	1.1	3.4	0.0	-0.8	1.0	1.0	0.7	1.9	1.2	-1.2	1.1	-1.3	0.9	1.0	0.7	1.0	0.6
Locomotion distance, session 1	1.0	1.2	3.0	1.0	-1.6	1.0	1.0	0.3	0.6	0.0	-0.0	1.4	-1.1	1.7	1.1	1.6	1.3	1.1
Bone: cortical thickness	1.0	1.2	2.4	-0.2	1.4	-1.2	-1.2	-0.5	-1.5	-1.0	1.0	-1.3	1.2	-1.1	-1.3	-1.1	-1.2	-0.6
Fecal boli incidents, locomotor time 1	1.0	1.1	3.0	-0.5	0.1	-1.2	-1.2	-0.6	-1.7	-0.9	0.9	-1.2	1.4	-1.0	-1.1	-0.7	-1.0	-0.9
Heart weight	0.9	1.3	8.5	0.6	-2.9	0.1	0.2	0.7	-1.6	-0.7	0.7	0.6	-0.4	1.1	1.3	1.1	0.9	1.4
Intraocular pressure	0.9	1.2	3.3	-1.5	0.9	-0.6	-0.9	-0.8	-1.2	-0.4	0.4	-1.0	0.9	-1.4	-0.9	-1.4	-1.4	-1.8
Soleus weight	0.9	2.6	4.5	-1.9	1.7	-1.2	-1.5	-1.2	-1.7	-0.5	0.5	-1.7	1.4	-2.1	-1.4	-2.1	-2.0	-2.0
Number of licking bursts	0.9	1.0	5.3	-1.2	0.2	0.2	-0.0	2.3	-0.0	1.0	-1.0	-0.3	-0.1	-1.1	0.1	-1.0	0.5	2.1
Cocaine response before conditioning	0.9	1.1	4.3	0.6	-0.1	-0.5	-0.6	-2.1	-1.2	-1.5	1.6	-0.2	0.7	0.3	-0.7	0.4	-0.9	-1.7
Pavlov. Cond. latency score	0.9	1.1	3.7	1.9	-1.0	-0.4	-0.4	-1.5	-0.8	-1.6	1.6	0.3	0.2	1.3	-0.3	1.3	-0.1	-0.6
Pavlov. Cond. lever contacts	0.9	1.2	3.6	1.5	-0.7	-0.9	-0.8	-1.9	-1.2	-1.7	1.7	-0.2	0.5	0.7	-0.6	0.7	-0.6	-1.2
Pavlov. Cond. magazine entry number	0.9	1.2	4.5	-2.1	1.2	-0.0	0.0	1.0	0.4	1.3	-1.3	-0.8	0.2	-1.8	-0.2	-1.7	-0.5	-0.2
Short access day 1 locomotion	0.9	1.0	4.1	2.0	-1.1	0.4	0.2	-0.6	-0.1	-1.0	1.0	0.9	0.0	1.7	0.1	1.5	0.6	0.6
Locomotion velocity, session 7	0.9	1.0	4.3	2.1	0.6	-0.9	-0.9	-0.9	-0.9	-1.5	1.5	-0.4	0.7	0.7	-0.7	0.3	-0.3	0.2
Time in novel zone, hab. session 1	0.9	0.9	1.8	0.5	0.2	-1.3	-1.1	-0.8	-1.2	-1.1	1.1	-1.1	1.0	-0.5	-1.0	-0.6	-1.0	-0.4
Total zone transitions, hab. session 1	0.9	1.3	3.9	1.7	-1.8	0.7	0.7	-0.2	0.2	-0.6	0.6	1.3	-0.8	2.0	0.8	1.9	1.1	0.4
Ambulatory time before self-admin	0.9	1.0	2.4	1.5	-1.0	-0.4	-0.3	-1.6	-0.8	-1.5	1.5	0.1	0.7	0.7	-0.5	1.0	-0.2	-1.0
Delay disc. indifference point, 4s delay	0.9	0.9	4.0	2.0	-0.2	-0.2	-0.4	-1.6	0.1	-1.4	1.4	0.4	0.6	1.0	-0.4	0.9	-0.3	-0.3
Bouts of movement, locomotor time 2	0.9	1.0	2.1	-0.9	1.0	-0.6	-0.9	-0.8	-1.1	-0.5	0.6	-1.0	0.9	-1.1	-0.7	-1.3	-1.2	-1.5
Progressive ratio	0.9	1.1	1.7	0.0	-0.2	1.2	1.3	1.0	1.2	0.9	-0.9	1.2	-0.7	1.0	1.3	1.0	1.3	1.3
Co content in liver	0.9	1.0	2.9	-1.7	-0.6	0.7	0.8	1.7	0.5	1.5	-1.5	0.4	-0.9	-0.4	0.9	-0.4	0.7	1.0
Liver weight, left	0.8	1.3	6.7	-2.6	0.5	0.2	0.2	1.2	0.4	1.6	-1.6	-0.5	-0.3	-1.5	0.5	-1.6	-0.2	-0.2
Times rat made contact with spout	0.8	0.9	1.5	-0.0	0.6	-1.1	-1.2	-0.2	-1.2	-0.8	0.8	-1.2	1.0	-1.0	-1.1	-1.0	-1.0	-0.3
Delay discounting water rate 0 sec	0.8	1.3	10.5	-3.2	0.0	0.1	0.1	1.0	-1.2	1.0	-0.9	-0.6	-0.1	-1.3	0.6	-1.3	-0.3	-1.0
Reaction time false alarm rate	0.8	1.1	3.2	1.8	0.1	-0.3	-0.5	-1.8	-0.7	-1.7	1.7	0.2	0.8	0.9	-0.2	0.8	-0.5	-1.0
Intermitt. access day 1 inactive lever presses	0.8	0.8	2.4	-1.5	-0.0	0.9	0.9	1.5	0.3	1.1	-1.1	0.5	-0.4	-0.1	1.0	-0.2	0.7	1.6
Intermittent access standard deviation	0.8	0.8	2.8	-1.7	0.6	0.5	0.4	1.2	1.1	1.5	-1.5	-0.1	-0.3	-0.6	0.5	-1.0	0.1	0.4
Short access day 10 total locomotion	0.8	0.8	1.7	-0.2	-1.3	1.1	1.2	0.1	1.0	0.6	-0.6	1.1	-1.1	1.2	1.1	0.9	0.8	0.1
Locomotion velocity, hab. session 1	0.8	1.1	3.3	1.7	-1.5	0.5	0.4	-0.9	0.3	-0.8	0.8	1.1	-0.5	1.8	0.5	1.7	0.7	-0.2
Pavlov. Cond. lever contacts	0.8	1.0	3.2	1.3	-0.2	1.1	0.9	-0.5	0.8	-0.3	0.3	1.2	-0.8	1.7	0.9	1.8	0.9	0.3
Bone: stiffness	0.8	1.3	2.8	0.2	0.9	-1.1	-1.4	-1.0	-1.7	-1.3	1.3	-1.1	1.3	-0.8	-1.3	-0.8	-1.2	-1.0
Bouts of movement, locomotor time 1	0.8	0.9	1.6	-0.7	0.9	-0.9	-1.0	-0.2	-1.2	-0.5	0.5	-1.3	0.8	-1.1	-0.6	-1.2	-1.0	-1.2
Total resting periods, locomotor time 2	0.8	0.9	2.0	-1.0	1.3	-0.5	-0.8	-0.6	-0.9	-0.3	0.3	-0.9	0.7	-1.2	-0.6	-1.4	-1.2	-1.4
Vertical activity count, locomotor time 2	0.8	0.9	2.4	-1.2	0.5	-0.8	-0.8	1.0	-1.1	0.1	-0.0	-1.2	0.9	-1.5	-0.7	-1.4	-0.6	0.3
Run reversals in cocaine runway, males	0.8	0.7	1.5	-0.6	-1.0	1.1	0.9	1.2	0.3	0.7	-0.7	1.0	-0.9	0.6	1.0	0.5	1.1	0.9
Latency to leave start box in cocaine runway, M	0.8	0.8	2.9	1.0	-1.7	0.4	0.6	-0.5	-0.4	-0.7	0.7	1.0	-0.4	1.4	0.3	1.4	0.6	0.4
Delay discounting total patch changes 6 sec	0.7	1.1	5.0	-2.2	-0.3	0.7	0.9	0.9	0.7	1.5	-1.5	0.3	-1.0	-0.6	1.5	-0.4	0.3	-0.8
Reaction time num false alarms	0.7	0.9	2.6	1.6	-0.4	-0.3	-0.4	-1.3	-1.0	-1.6	1.6	0.2	0.6	1.1	0.1	0.9	-0.2	-0.6
Saline control response	0.7	0.9	2.4	-1.5	-0.0	-0.8	-0.8	0.6	-1.5	-0.1	0.1	-1.1	0.8	-1.4	-0.8	-1.5	-0.8	-0.2
Intermittent access intake day 1-15 change	0.7	0.7	3.1	-1.8	1.2	-0.1	-0.1	1.1	-0.2	0.8	-0.8	-0.6	0.1	-1.0	0.1	-1.2	-0.2	0.0
Intermittent access day 1 total infusions	0.7	0.8	3.6	1.4	-1.0	0.5	0.5	-0.6	-0.1	-0.7	0.7	1.0	-0.5	1.9	0.4	1.4	0.7	0.3
One hour access (shock baseline)	0.7	0.9	2.8	-0.4	0.8	-0.9	-1.0	-0.6	-1.7	-1.0	1.0	-0.8	1.0	-0.2	-0.8	-0.7	-0.9	-1.3
Condit. Reinf. inactive responses	0.7	0.8	2.6	0.7	-1.6	0.7	0.9	-0.1	0.0	-0.3	0.3	1.1	-0.8	1.4	0.8	1.5	0.9	0.5
Pavlov. Cond. magazine entry number	0.7	0.9	2.4	-0.2	-1.0	0.6	0.8	1.1	1.1	1.1	-1.2	0.7	-0.9	0.4	0.9	0.2	1.0	1.5
Time in closed arm before self-admin	0.7	0.8	2.3	-1.5	1.1	-0.7	-0.6	0.7	-0.8	0.4	-0.4	-0.9	0.3	-1.5	-0.6	-1.4	-0.6	-0.1
Time to tail flick, vehicle, before self-admin	0.7	0.7	4.6	2.1	-0.3	-0.7	-0.5	-0.7	-0.1	-1.2	1.2	-0.1	0.6	0.7	-0.6	0.8	0.0	0.5
Total resting periods, locomotor time 1	0.7	0.8	1.6	-0.6	0.8	-0.9	-1.0	-0.4	-1.2	-0.6	0.6	-1.2	0.9	-1.0	-0.7	-1.0	-1.0	-1.2
Mn content in liver	0.7	0.8	1.6	0.0	-0.4	0.7	1.0	1.3	1.0	1.0	-1.0	0.6	-1.0	0.7	0.9	0.7	1.1	1.2
Reaction time omissions	0.6	0.9	2.7	1.6	-1.3	0.1	-0.1	-1.2	-0.3	-1.2	1.2	0.7	0.1	1.2	-0.0	1.4	0.2	-0.0
Cocaine response after cond. not corrected	0.6	0.7	2.6	0.3	1.5	-0.5	-0.6	-1.1	0.5	-0.2	0.2	-0.7	0.6	-0.7	-0.6	-0.6	-0.9	-1.6
Condit. Reinf. inactive responses	0.6	0.7	3.4	-0.4	0.5	-0.8	-0.7	-1.1	-0.9	-0.6	0.7	-0.8	0.6	-0.5	-0.6	-0.6	-1.0	-1.8
Condit. Reinf. lever presses	0.6	0.8	2.5	0.1	0.1	-1.0	-0.9	-1.4	-1.1	-1.0	1.1	-0.8	0.6	-0.2	-0.6	-0.3	-1.0	-1.6
Intermitt. access day 15 inactive lever presses	0.6	0.7	2.6	-0.8	0.9	0.6	0.7	0.9	1.6	1.3	-1.3	0.2	-0.1	-0.3	0.6	-0.4	0.4	0.6
Short access total locomotion	0.6	0.6	2.2	1.2	-1.1	0.5	0.4	-0.6	0.6	-0.3	0.3	0.8	-0.2	1.5	0.4	1.1	0.5	0.2
One hour access (0.3 mA shock)	0.6	0.7	1.7	-0.6	-0.5	0.9	0.8	1.1	-0.3	0.4	-0.4	0.9	-0.9	1.3	1.1	0.7	1.0	0.8
Stereotopy head waving bouts, day 7	0.6	0.7	3.4	0.5	-1.8	0.7	0.8	0.0	0.5	0.0	-0.0	1.0	-0.8	1.2	0.8	1.2	0.8	0.5
Degree of sensitization distance	0.6	0.6	3.4	1.8	-0.7	-0.1	-0.1	-0.1	-0.4	-0.9	0.9	0.5	0.1	1.1	-0.1	1.0	0.5	0.8
Total locomotion distance, NPP test	0.6	0.9	2.6	1.3	-0.7	-0.5	-0.7	-1.6	-0.8	-1.4	1.4	-0.1	0.6	0.6	-0.6	0.5	-0.6	-1.2
Locomotion velocity, NPP test	0.6	0.9	2.1	1.1	-1.1	-0.4	-0.7	-1.4	-1.0	-1.4	1.4	-0.0	0.6	0.6	-0.6	0.5	-0.5	-1.1
Pavlov. Cond. change in total contacts	0.6	0.6	2.8	1.7	0.5	-0.2	-0.5	-1.3	-0.1	-1.2	1.2	-0.0	0.5	0.6	-0.5	0.6	-0.4	-0.7
Distance traveled before self-admin	0.6	0.6	2.4	1.5	-1.5	-0.1	0.1	-0.7	-0.4	-1.0	1.0	0.4	0.3	0.9	0.0	1.2	0.3	0.1
Time to tail flick, test, before self-admin	0.6	0.5	1.5	-0.6	0.7	-0.9	-0.9	0.1	-0.8	-0.1	0.1	-1.1	0.6	-1.0	-0.6	-1.2	-0.8	-0.1
Delay disc. indifference point, 8s delay	0.6	0.6	2.4	1.5	-1.0	-0.1	-0.1	-0.8	-0.3	-1.1	1.1	0.4	0.2	0.9	-0.2	1.1	0.1	0.3
Time >=10cm from walls, locomotor time 1	0.6	0.6	2.0	1.4	-0.2	0.2	0.1	-1.4	0.5	-0.7	0.7	0.5	-0.1	1.3	-0.1	1.2	0.0	-0.3
Rest time, locomotor task time 1	0.6	0.7	1.8	-0.4	1.0	-0.8	-0.9	-0.6	-0.8	-0.4	0.5	-0.9	0.7	-0.9	-0.9	-0.8	-1.0	-1.3
Weight adjusted by age	0.6	0.7	2.6	-1.6	1.4	-0.1	-0.2	0.5	-0.0	0.8	-0.8	-0.6	0.1	-1.3	-0.3	-1.5	-0.6	-0.4
Na content in liver	0.6	0.6	0.9	0.5	0.9	-0.9	-0.8	-0.9	-0.7	-0.8	0.8	-0.8	0.8	-0.5	-0.9	-0.5	-0.9	-0.8
Mean num. licks in bursts	0.5	0.6	2.9	0.6	0.2	-0.6	-0.4	-1.6	-0.4	-0.8	0.9	-0.3	0.4	0.2	-0.4	0.1	-0.8	-1.7
Delay discounting total patch changes 12 sec	0.5	0.6	2.6	-1.6	1.0	0.3	0.4	0.3	0.8	1.1	-1.1	-0.1	-0.5	-0.8	0.6	-0.6	-0.2	-1.1
Delay discounting water rate 24 sec	0.5	0.6	2.8	-1.3	-0.1	-0.4	-0.5	0.0	-1.7	-0.3	0.3	-0.7	0.8	-1.1	-0.4	-0.9	-0.7	-0.5
Light reinforcement 1	0.5	1.0	4.7	2.2	-0.9	-0.4	-0.3	-1.1	-0.4	-1.4	1.4	0.2	0.3	1.2	-0.9	1.2	0.1	0.3
Reaction time num false alarms AUC	0.5	0.7	2.0	1.1	-0.3	-0.2	-0.3	-1.4	-0.9	-1.4	1.4	0.2	0.6	0.9	0.3	0.7	-0.3	-1.1
Pavlov. Cond. change in total contacts	0.5	0.7	1.7	1.2	-1.3	-0.5	-0.5	-0.9	-1.1	-1.3	1.3	0.0	0.2	0.9	-0.3	0.9	-0.1	0.0
Intermittent access intake escalation	0.5	0.5	2.1	-1.5	1.3	-0.3	-0.3	0.6	-0.5	0.4	-0.4	-0.7	0.3	-0.9	-0.1	-1.1	-0.4	-0.4
Intermittent access day 15 total locomotion	0.5	0.6	2.1	0.5	-0.6	0.4	0.3	-0.8	-0.9	-0.9	0.9	0.7	0.1	1.4	0.4	1.1	0.2	-0.7
Progressive ratio test 2 active lever presses	0.5	0.5	2.3	0.1	0.5	-0.8	-0.9	-0.2	-1.5	-0.9	1.0	-0.7	0.8	0.0	-0.7	-0.4	-0.6	-0.4
Progressive ratio test 2 inactive lever presses	0.5	0.5	4.1	-2.0	0.7	0.0	-0.1	0.8	-1.0	0.4	-0.4	-0.4	0.3	-0.5	0.3	-0.9	-0.3	-0.2
Short access day 10 total infusions	0.5	0.5	2.1	0.6	-0.6	0.7	0.7	-0.2	0.8	0.2	-0.2	0.8	-0.9	1.5	0.7	1.0	0.7	-0.1
Locomotion distance, session 7	0.5	0.7	1.8	1.3	0.9	-0.4	-0.6	-0.8	-1.1	-1.3	1.3	-0.1	0.5	0.7	-0.5	0.4	-0.1	-0.5
Stereotopy head waving duration, day 7	0.5	0.7	2.5	0.6	-1.6	0.6	0.7	0.3	0.6	0.2	-0.2	0.9	-0.7	1.1	0.7	1.1	0.9	0.8
Locomotion velocity, session 8	0.5	0.6	1.1	0.9	0.3	-1.0	-0.8	-0.6	-0.8	-1.0	1.0	-0.9	0.9	-0.3	-0.9	-0.2	-0.7	-0.0
Bone: endosteal perimeter	0.5	1.1	3.1	-1.2	0.8	-0.8	-0.9	-0.8	-1.3	-0.5	0.5	-1.0	0.8	-1.1	-0.8	-1.1	-1.2	-1.8
Extinction: sum of active levers before priming	0.5	0.5	1.4	1.2	-1.2	0.3	0.3	-0.8	0.3	-0.5	0.5	0.7	-0.3	1.1	0.4	1.1	0.3	0.0
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.1	-0.4	-0.8	0.7	0.8	0.3	0.4	0.6	-0.6	0.8	-1.1	0.6	0.9	0.6	0.7	0.1
Delay disc. indifference point, 24s delay	0.5	0.5	1.8	1.3	-0.7	0.3	0.2	-0.1	0.3	-0.6	0.6	0.6	-0.0	1.0	0.2	1.0	0.5	1.2
Change in fecal boli incidents, locomotor task	0.5	0.5	1.8	0.1	0.2	0.5	0.6	0.7	1.4	0.8	-0.8	0.5	-0.9	0.3	0.5	-0.0	0.6	1.3
Cu content in liver	0.5	0.6	2.2	-0.9	-0.6	0.8	0.8	0.3	0.5	0.8	-0.8	0.7	-1.1	0.4	1.5	0.4	0.6	-0.5
Retroperitoneal fat weight	0.4	1.4	6.2	2.3	-0.3	-0.6	-0.5	-2.5	0.6	-1.1	1.1	0.1	0.3	0.8	-0.6	0.9	-0.6	-1.7
Indifference point AUC	0.4	0.4	1.0	-0.9	0.1	-0.7	-0.6	0.1	-0.7	-0.1	0.1	-0.9	0.4	-1.0	-0.2	-1.0	-0.7	-0.9
Delay discounting time to switch 0 sec	0.4	0.6	4.4	2.1	0.7	0.1	-0.1	-0.8	1.5	-0.3	0.2	0.4	0.2	0.5	-0.5	0.7	0.1	0.5
Delay discounting water rate 18 sec	0.4	0.5	1.5	0.4	-1.2	0.5	0.3	-0.5	-0.9	-0.9	0.9	0.8	-0.2	0.9	-0.0	1.1	0.3	0.1
Locomotor testing rearing	0.4	0.6	1.3	-1.1	-0.4	0.8	1.1	0.6	0.7	1.1	-1.1	0.6	-1.0	0.2	1.1	0.2	0.6	0.2
Light reinforcement 2	0.4	0.5	1.8	0.0	-0.5	0.8	0.6	1.0	0.7	0.7	-0.7	0.7	-0.6	0.5	0.4	0.5	0.9	1.3
Cocaine response after cond. corrected	0.4	0.4	2.2	-0.1	1.5	-0.3	-0.3	-0.1	1.0	0.5	-0.5	-0.5	0.3	-0.8	-0.3	-0.8	-0.5	-0.7
Intermittent access total infusions	0.4	0.4	2.4	1.0	-0.4	0.3	0.2	-0.5	0.1	-0.5	0.5	0.6	-0.3	1.5	0.2	0.9	0.3	-0.1
Cocaine induced anxiety	0.4	0.4	1.9	0.7	-0.3	0.3	0.2	-1.2	-0.1	-0.6	0.6	0.5	-0.1	0.9	0.1	0.9	-0.0	-1.4
Progressive ratio test 2 breakpoint	0.4	0.4	2.0	0.5	0.2	-0.6	-0.7	-0.1	-1.4	-1.0	1.0	-0.3	0.6	0.4	-0.5	0.1	-0.2	-0.0
Locomotion velocity, session 3	0.4	0.5	1.2	0.1	0.9	-0.7	-0.6	-1.0	-0.6	-0.7	0.8	-0.7	0.7	-0.3	-0.7	-0.3	-0.8	-1.1
Total locomotion distance, hab. session 1	0.4	0.5	1.7	1.3	-0.9	0.1	0.1	-1.0	0.1	-0.7	0.7	0.6	-0.2	1.2	0.2	1.1	0.2	-0.7
Pavlov. Cond. magazine entry latency	0.4	0.5	1.7	0.2	1.3	-0.3	-0.5	-0.6	-0.6	-0.8	0.8	-0.6	0.7	-0.3	-0.7	-0.1	-0.6	-0.8
Bone: endosteal estimation	0.4	0.8	4.1	-2.0	0.7	-0.3	-0.3	0.6	-0.5	0.7	-0.7	-0.8	0.2	-1.4	-0.2	-1.4	-0.5	-0.6
Bone: marrow area	0.4	0.8	4.4	-2.1	0.7	-0.2	-0.2	0.7	-0.5	0.8	-0.7	-0.7	0.2	-1.3	-0.1	-1.3	-0.4	-0.5
Time to tail flick, test, after self-admin	0.4	0.4	0.8	0.5	0.9	-0.8	-0.7	-0.6	-0.1	-0.4	0.4	-0.7	0.8	-0.5	-0.7	-0.5	-0.7	-0.5
Delay disc. indifference point, 16s delay	0.4	0.4	2.1	1.4	-0.4	-0.2	-0.2	-0.6	-0.2	-1.0	1.0	0.2	0.3	0.7	-0.3	0.8	0.1	0.3
Run reversals in cocaine runway, females	0.4	0.4	1.0	-0.1	-0.3	0.5	0.8	0.2	0.6	0.5	-0.5	0.7	-1.0	0.6	0.7	0.7	0.7	0.2
Mg content in liver	0.4	0.4	0.7	-0.3	0.8	-0.7	-0.6	-0.2	-0.6	-0.2	0.3	-0.9	0.6	-0.8	-0.3	-0.8	-0.7	-0.7
Epididymis fat weight	0.3	0.8	4.1	0.2	-0.3	-0.8	-0.5	-1.6	-0.5	-0.8	0.8	-0.5	0.6	-0.3	-0.6	-0.2	-0.9	-2.0
Food consumed during 24 hour testing period	0.3	0.4	1.4	-1.2	-0.2	0.4	0.3	1.0	0.2	0.8	-0.8	0.1	-0.5	-0.5	0.5	-0.4	0.3	0.3
Reaction time number correct	0.3	0.5	2.9	-1.7	-0.7	-0.0	0.2	0.9	-0.5	0.7	-0.7	-0.2	-0.5	-0.4	0.6	-0.6	0.1	-0.0
Reaction time trials correct on left	0.3	0.5	2.9	-1.7	-0.7	-0.0	0.2	0.9	-0.5	0.7	-0.7	-0.2	-0.5	-0.4	0.6	-0.6	0.1	-0.0
Reaction time trials on left	0.3	0.4	2.6	-1.6	-0.8	-0.0	0.2	0.8	-0.6	0.7	-0.6	-0.2	-0.4	-0.4	0.6	-0.6	0.1	-0.0
Reaction time premature initiation rate	0.3	0.5	1.3	1.0	0.1	-0.5	-0.6	-0.8	-0.8	-1.1	1.1	-0.2	0.8	0.1	-0.7	0.4	-0.4	-0.1
Reaction time trials completed	0.3	0.4	2.6	-1.6	-0.8	-0.0	0.2	0.8	-0.6	0.7	-0.6	-0.2	-0.4	-0.4	0.6	-0.6	0.1	-0.0
Reaction time trials AUC	0.3	0.4	2.4	-1.6	-0.9	0.1	0.4	0.8	-0.4	0.7	-0.7	-0.0	-0.6	-0.2	0.8	-0.3	0.3	-0.1
Conditioned locomotion	0.3	0.3	1.1	-1.0	0.3	0.7	0.6	-0.1	0.8	0.8	-0.8	0.4	-0.5	-0.2	0.5	-0.2	0.1	-0.5
Conditioned reinforcement - inactives	0.3	0.3	1.2	-1.0	0.5	0.4	0.3	1.1	0.1	0.7	-0.7	0.0	-0.0	-0.0	0.5	-0.4	0.3	0.8
Intermittent access intake escalation 2	0.3	0.2	0.9	-0.9	0.5	0.6	0.5	0.7	0.2	0.6	-0.6	0.3	-0.5	0.1	0.5	-0.1	0.3	0.2
Intermitt. access escalation Index	0.3	0.3	0.9	0.3	-0.6	0.2	0.4	-0.3	-0.4	-0.3	0.3	0.6	-0.8	0.8	0.5	1.0	0.5	-0.3
Lifetime Intake	0.3	0.3	1.7	1.0	-0.4	0.2	0.1	-0.4	0.4	-0.3	0.3	0.5	-0.3	1.3	0.2	0.7	0.3	-0.0
Locomotion velocity, session 1	0.3	0.4	1.3	1.1	-1.1	-0.1	0.1	-0.4	-0.2	-0.6	0.6	0.4	-0.1	0.9	0.1	0.9	0.3	0.1
Locomotion velocity, session 2	0.3	0.3	1.4	1.1	-1.2	-0.1	0.0	0.3	-0.2	-0.5	0.5	0.2	0.0	0.6	-0.0	0.6	0.5	1.1
Locomotion distance, session 3	0.3	0.4	0.9	-0.8	0.6	0.9	0.7	0.4	0.4	0.6	-0.6	0.5	-0.8	0.4	0.8	0.2	0.5	0.0
Degree of sensitization stereotypy	0.3	0.4	1.2	0.8	-1.1	0.4	0.4	-0.2	0.3	-0.2	0.2	0.7	-0.4	1.0	0.4	1.0	0.5	0.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.2	1.0	0.3	-0.4	-0.3	-1.1	-0.0	-0.7	0.7	-0.1	0.4	0.4	-0.3	0.4	-0.4	-0.6
Condit. Reinf. active responses	0.3	0.4	1.2	0.8	-0.9	0.2	0.4	-0.6	0.1	-0.5	0.5	0.6	-0.3	1.0	0.4	1.1	0.4	-0.2
Incentive salience index mean	0.3	0.4	1.2	0.7	-0.5	0.4	0.5	-0.7	0.3	-0.3	0.3	0.7	-0.5	1.1	0.5	1.1	0.4	-0.5
Condit. Reinf. lever presses	0.3	0.3	1.0	0.3	-0.4	0.5	0.4	-0.8	0.0	-0.4	0.4	0.7	-0.5	1.0	0.5	1.0	0.3	-0.7
Time in novel zone, hab. session 2	0.3	0.3	0.9	0.6	-0.6	0.2	0.3	0.1	-0.2	-0.3	0.3	0.6	-0.4	1.0	0.4	1.0	0.6	0.8
Novelty place preference	0.3	0.3	2.3	0.8	-0.8	-0.1	0.1	0.6	-0.1	-0.1	0.1	0.3	-0.2	0.6	0.2	0.5	0.6	1.5
Pavlov. Cond. index score	0.3	0.4	1.1	0.8	1.0	0.1	-0.1	-0.9	-0.1	-0.8	0.8	0.0	0.3	0.5	-0.2	0.6	-0.3	-0.8
Pavlov. Cond. latency score	0.3	0.4	1.3	1.1	0.9	0.3	-0.0	-1.0	-0.0	-0.9	0.9	0.2	0.1	0.8	-0.1	0.9	-0.1	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.8	0.6	1.3	0.2	-0.1	-0.9	0.0	-0.6	0.6	-0.0	0.2	0.3	-0.2	0.5	-0.3	-0.8
Pavlov. Cond. response bias	0.3	0.4	1.1	0.5	1.0	-0.2	-0.4	-1.0	-0.5	-0.9	0.9	-0.3	0.5	0.0	-0.5	0.2	-0.6	-1.0
Bone: cortical apparent density	0.3	0.3	2.2	1.5	0.5	-0.2	-0.2	-0.5	0.0	-0.7	0.7	0.1	0.2	0.7	-0.2	0.7	0.1	0.5
Bone: post-yield work	0.3	0.5	3.5	-0.9	0.8	-0.3	-0.2	-0.7	-0.2	0.0	-0.0	-0.5	0.2	-0.5	-0.2	-0.6	-0.6	-1.9
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	0.6	0.4	-0.3	-0.2	-0.3	-0.8	-0.8	0.8	-0.2	0.8	0.3	-0.4	0.3	-0.1	-0.3
Delta ambulatory time before/after self-admin	0.3	0.3	0.6	-0.6	-0.2	0.5	0.4	0.6	0.4	0.6	-0.6	0.3	-0.7	0.3	0.7	-0.1	0.4	0.8
Sum of active levers in priming session hrs 5-6	0.3	0.3	1.2	0.9	-0.1	-0.2	-0.2	-1.1	0.6	-0.4	0.4	-0.0	0.4	0.2	-0.2	0.2	-0.4	-1.1
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.2	1.1	-0.7	-0.4	-0.1	-0.4	-0.4	-0.8	0.7	0.1	-0.0	0.6	0.0	0.7	0.2	0.2
Distance moved, locomotor task time 1	0.3	0.4	1.4	0.8	-1.2	0.2	0.2	0.1	-0.1	-0.3	0.3	0.6	-0.2	0.8	0.3	0.8	0.6	1.0
Seeking ratio, punishment vs. effort	0.3	0.4	1.1	-1.0	0.4	-0.3	-0.4	-0.1	-0.1	0.3	-0.3	-0.6	0.0	-1.0	-0.4	-1.0	-0.6	-0.8
Latency to leave start box in cocaine runway, F	0.3	0.4	0.8	0.2	0.6	-0.8	-0.6	0.5	-0.0	0.1	-0.1	-0.8	0.8	-0.8	-0.7	-0.9	-0.4	0.6
Glucose	0.2	0.2	2.0	1.4	-0.1	-0.4	-0.2	-0.2	0.1	-0.5	0.5	0.1	0.1	0.6	-0.1	0.5	0.2	0.5
Parametrial fat weight	0.2	0.3	1.0	-0.5	0.4	-0.3	-0.3	0.9	0.3	0.7	-0.7	-0.5	0.1	-1.0	-0.2	-0.9	-0.1	0.6
Std. dev. time between licks in bursts	0.2	0.2	1.0	-0.2	0.3	-0.2	-0.1	-0.5	-0.7	-0.5	0.6	-0.1	0.3	0.0	-0.3	0.2	-0.3	-1.0
Indifference point function ln k	0.2	0.3	0.8	-0.5	-0.3	0.7	0.6	0.6	-0.0	0.4	-0.4	0.6	-0.5	0.4	0.6	0.3	0.6	0.9
Indifference point function log k	0.2	0.3	0.8	-0.5	-0.3	0.7	0.6	0.6	-0.0	0.4	-0.4	0.6	-0.5	0.4	0.6	0.3	0.6	0.9
Delay discounting water rate 12 sec	0.2	0.3	1.1	-1.1	-1.0	0.5	0.5	0.3	-0.7	0.1	-0.1	0.5	-0.4	0.2	0.5	0.3	0.3	0.1
Delay discounting water rate 6 sec	0.2	0.3	1.7	-1.3	-0.2	0.3	0.2	-0.3	-0.7	0.1	-0.0	0.1	-0.2	0.0	0.4	-0.1	-0.1	-1.2
Locomotor testing distance	0.2	0.4	1.5	-1.2	0.1	-0.5	-0.2	0.3	-0.8	0.1	-0.1	-0.7	0.4	-0.9	0.1	-0.9	-0.5	-0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.7	-0.8	0.2	-0.4	-0.3	0.4	-0.7	0.0	-0.0	-0.6	0.4	-0.8	-0.4	-0.8	-0.4	-0.3
Intermittent access terminal intake (last 3 days)	0.2	0.2	1.1	0.1	-0.2	0.6	0.5	0.2	0.4	0.2	-0.2	0.7	-0.7	1.0	0.5	0.6	0.5	0.2
Incentive Sensitization - Responses	0.2	0.2	0.6	0.4	-0.1	0.1	0.2	-0.1	-0.7	-0.5	0.5	0.4	-0.2	0.8	0.2	0.7	0.3	-0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.7	0.4	-0.1	0.1	0.2	-0.2	-0.7	-0.5	0.5	0.4	-0.3	0.8	0.2	0.7	0.3	-0.2
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	-0.2	0.6	-0.5	-0.6	0.2	-0.6	-0.3	0.3	-0.5	0.4	-0.0	-0.4	-0.5	-0.3	0.1
Progressive ratio test 1 breakpoint	0.2	0.3	0.5	-0.1	0.6	-0.7	-0.7	0.2	-0.6	-0.4	0.4	-0.7	0.5	-0.2	-0.6	-0.6	-0.4	0.2
Progressive ratio test 1 inactive lever presses	0.2	0.2	1.0	-1.0	0.4	-0.1	-0.0	0.8	-0.7	0.2	-0.2	-0.2	0.3	-0.2	0.1	-0.5	0.0	0.8
Short access day 1 total inactive lever presses	0.2	0.3	0.7	-0.5	0.3	0.6	0.5	0.9	0.4	0.6	-0.6	0.4	-0.3	0.1	0.5	0.0	0.5	0.8
Short access total infusions	0.2	0.2	1.1	0.8	-0.4	0.1	-0.0	0.0	1.0	0.2	-0.2	0.2	-0.2	0.7	-0.0	0.2	0.3	0.4
Condit. Reinf. active minus inactive responses	0.2	0.3	1.0	1.0	-0.3	0.1	0.3	-0.6	0.4	-0.4	0.4	0.4	-0.2	0.9	0.2	0.9	0.3	-0.2
Total locomotion distance, hab. session 2	0.2	0.2	0.9	0.6	-0.9	0.3	0.1	0.1	-0.1	-0.3	0.3	0.5	-0.2	0.7	0.2	0.6	0.4	0.3
Locomotion velocity, hab. session 2	0.2	0.2	1.1	0.6	-1.0	0.3	0.2	0.3	-0.1	-0.2	0.2	0.5	-0.2	0.7	0.2	0.6	0.5	0.4
Novel to familiar place preference ratio	0.2	0.2	1.9	0.6	-0.5	-0.3	-0.2	0.5	-0.3	-0.2	0.2	-0.0	0.0	0.3	-0.0	0.2	0.4	1.4
Time in novel zone, NPP test	0.2	0.2	1.8	0.7	-0.6	-0.2	-0.1	0.4	-0.2	-0.2	0.2	0.1	-0.0	0.4	0.0	0.3	0.4	1.3
Bone: cortical tissue density	0.2	0.3	1.9	1.4	0.4	-0.0	0.0	-0.3	0.2	-0.6	0.5	0.3	0.0	0.7	-0.0	0.8	0.3	0.6
Bone: elastic displacement	0.2	0.3	0.8	-0.8	0.4	-0.5	-0.4	0.1	-0.4	0.1	-0.1	-0.7	0.4	-0.8	-0.3	-0.9	-0.6	-0.1
Distance traveled after self-admin	0.2	0.2	1.4	0.4	-1.2	-0.4	-0.2	-0.3	-0.7	-0.6	0.6	-0.1	0.2	0.3	-0.0	0.3	-0.0	0.1
Diff in mean of infusions in LGA sessions	0.2	0.2	1.5	-0.0	-0.1	-0.2	-0.1	-0.8	-0.5	-0.5	0.5	-0.1	0.1	0.1	-0.1	0.1	-0.4	-1.2
Active lever presses in extinction session 6	0.2	0.1	0.7	-0.2	0.0	-0.3	-0.3	-0.5	-0.3	-0.2	0.2	-0.5	0.2	-0.3	-0.3	-0.3	-0.5	-0.9
Delta distance traveled before/after self-admin	0.2	0.2	0.8	-0.9	0.2	0.1	-0.0	0.7	-0.1	0.5	-0.5	-0.2	-0.3	-0.3	0.2	-0.6	0.0	0.7
Time in closed arm after self-admin	0.2	0.3	1.8	-0.6	0.3	-0.4	-0.2	0.4	-1.3	-0.3	0.3	-0.3	0.5	-0.4	-0.5	-0.2	-0.1	-0.0
Time in open arm before self-admin	0.2	0.2	0.6	0.6	0.1	-0.3	-0.4	-0.3	-0.7	-0.8	0.8	-0.3	0.8	0.1	-0.4	-0.0	-0.3	-0.0
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	0.2	0.3	0.5	0.4	-0.4	0.8	0.2	-0.2	0.5	-0.1	0.3	0.3	0.4	0.2	-0.5
Ambulatory time after self-admin	0.2	0.3	1.1	0.6	-1.0	-0.4	-0.3	-0.8	-0.5	-0.8	0.8	-0.1	0.2	0.4	-0.1	0.3	-0.2	-0.3
Distance moved, locomotor task time 2	0.2	0.3	2.1	-0.2	-0.2	-0.0	-0.1	1.1	-0.1	0.3	-0.3	-0.1	-0.0	-0.4	0.0	-0.1	0.3	1.4
Latency to leave start box in cocaine runway	0.2	0.3	1.3	1.2	-0.0	-0.5	-0.4	-0.1	-0.2	-0.5	0.5	-0.3	0.5	0.1	-0.7	-0.0	-0.1	0.8
K content in liver	0.2	0.2	1.3	0.1	0.3	-0.4	-0.2	-0.6	-0.2	-0.2	0.2	-0.4	0.2	-0.2	0.1	-0.2	-0.4	-1.2
Reaction time premature initiations	0.1	0.2	0.8	0.2	-0.3	-0.4	-0.4	-0.4	-0.9	-0.7	0.7	-0.3	0.5	-0.1	-0.4	0.1	-0.3	-0.1
Intermittent access day 15 total infusions	0.1	0.1	0.7	-0.3	0.1	0.4	0.3	0.2	-0.2	0.0	-0.0	0.4	-0.4	0.9	0.5	0.3	0.3	-0.1
Total sessions with >9 infusions	0.1	0.1	0.3	0.4	-0.1	-0.4	-0.5	-0.5	-0.3	-0.5	0.5	-0.3	0.3	0.3	-0.5	-0.0	-0.3	-0.4
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	-0.2	0.3	0.2	0.4	0.0	0.3	-0.3	0.2	-0.4	0.4	0.3	0.1	0.3	0.2
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.3	-0.5	-0.2	-0.0	0.1	0.3	0.3	-0.3	-0.1	0.1	-0.5	-0.1	-0.4	-0.1	0.2
Time in familiar zone, hab. session 2	0.1	0.1	0.4	-0.1	0.5	0.1	-0.1	-0.2	0.4	0.2	-0.2	-0.2	0.2	-0.4	-0.2	-0.3	-0.3	-0.6
Total zone transitions, hab. session 2	0.1	0.1	0.4	0.4	-0.5	-0.3	-0.4	0.5	-0.6	-0.4	0.4	-0.2	0.4	-0.1	-0.4	-0.2	0.1	0.6
Total zone transitions, NPP test	0.1	0.2	0.5	0.5	-0.6	-0.3	-0.4	-0.3	-0.7	-0.7	0.7	-0.2	0.4	0.2	-0.4	0.0	-0.2	-0.2
Bone: cortical porosity	0.1	0.1	0.3	0.2	-0.2	0.4	0.4	-0.1	-0.0	-0.1	0.1	0.6	-0.3	0.5	0.4	0.5	0.3	0.4
Vertical activity count, locomotor time 1	0.1	0.1	0.5	0.2	-0.5	-0.2	-0.2	0.1	-0.7	-0.5	0.5	-0.2	0.2	-0.1	-0.1	-0.1	-0.0	0.2
Rest time, locomotor task time 2	0.1	0.1	0.3	0.0	-0.0	0.2	0.3	-0.4	0.3	0.0	-0.0	0.3	-0.5	0.6	0.2	0.3	0.1	-0.6
Locomotion in novel chamber	0.1	0.2	0.7	-0.5	-0.7	0.2	0.2	0.7	-0.8	-0.0	0.0	0.1	0.1	0.2	0.4	0.1	0.3	0.3
Bone: cortical porosity	0.0	0.0	0.2	-0.4	0.4	0.1	0.1	0.2	0.1	0.2	-0.2	0.0	-0.0	-0.2	0.1	-0.2	-0.0	0.3
Bone: minimum diameter	0.0	0.0	0.1	-0.2	0.0	0.1	0.1	0.2	-0.0	0.1	-0.1	0.1	-0.1	-0.0	0.2	-0.0	0.1	0.2
Time in open arm after self-admin	0.0	0.1	0.3	0.2	-0.0	0.2	-0.1	-0.4	0.6	0.1	-0.1	0.0	-0.1	0.1	0.2	-0.1	-0.2	-0.3

For each tested trait, stats based on TWAS chi² (squared Z-score) for the above models are shown. Avg chi² ratio is the mean chi² across all models for this gene, divided by the mean chi² across all models for all genes. Avg chi² is the mean chi² across all models for this gene. Max chi² is the highest chi² across all models for this gene.

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.