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Patch foraging water rate 0 sec

Delay discounting using a sequential patch depletion procedure, water consumption rate during the last two sessions with an experimenter-imposed delay of 0 sec

Tags: Behavior · Delay discounting

Project: p50_david_dietz

2 loci · 12 genes with independent associations · 272 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr6	129055047	132886544	271	11	1.69e-09	3.14e-09	1e+00	Ahnak2 Brf1 C6h14orf180 Cep170b Jag2 LOC120103628 Tedc1 Wdr20 Xrcc3 Zfyve21
2	chr9	75969545	77365260	1	1	1.74e-15	6.41e-01	1e+00	Zfand2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	8.42	1	1	8.3	0	1.00e+00	Zfand2b
BMI without tail	53.65	1	1	8.3	0	1.00e+00	Zfand2b
Epididymis fat weight	111.28	1	1	8.3	0	1.00e+00	Zfand2b
Heart weight	71.7	1	1	8.3	0	1.00e+00	Zfand2b
Left kidney weight	27.22	1	1	8.3	0	1.00e+00	Zfand2b
Right kidney weight	54.05	1	1	8.3	0	1.00e+00	Zfand2b
Tail length	6.08	23	1	8.3	0.89	4.62e-62	Ahnak2 Brf1 Btbd6 C6h14orf180 Cdca4 Cep170b Clba1 Crip1 Crip2 Gpr132 Inf2 Jag2 LOC108351305 LOC120103631 LOC120103632 Nudt14 Pacs2 Pld4 Siva1 Tedc1 Tex22 Tmem121 Zfand2b
Length with tail	7.6	47	22	183.3	0.98	3.88e-289	Ahnak2 Amn Aspg Bag5 Brf1 Btbd6 C6h14orf180 Cdc42bpb Cdca4 Cep170b Ckb Clba1 Coa8 Crip1 Crip2 Diras3 Eif5 Exoc3l4 Gpr132 Inf2 Jag2 Kif26a Klc1 Lbhd2 LOC108351305 LOC120103628 LOC120103629 LOC120103631 LOC120103632 Mark3 Nudt14 Pacs2 Pld4 Ppp1r13b Rd3l Siva1 Snora28l1 Tdrd9 Tedc1 Tex22 Tmem121 Tmem179 Tnfaip2 Traf3 Xrcc3 Zfand2b Zfyve21
Length without tail	11.93	8	1	8.3	0.95	9.33e-08	Ahnak2 Brf1 Cep170b Jag2 Nudt14 Pacs2 Tedc1 Zfand2b
Liver weight, right	17.57	1	1	8.3	0	1.00e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1.00e+00	Zfand2b
Retroperitoneal fat weight	7.53	1	0	0	0	1.00e+00	Zfand2b
Intraocular pressure	51.69	1	1	8.3	0	1.00e+00	Zfand2b
Extensor digitorum longus weight	7.81	49	31	258.3	0.99	0.00e+00	Ahnak2 Amn Aspg Bag5 Brf1 Btbd6 C6h14orf180 Cdc42bpb Cdca4 Cep170b Cinp Ckb Clba1 Coa8 Crip1 Crip2 Diras3 Eif5 Exoc3l4 Gpr132 Inf2 Jag2 Kif26a Klc1 Lbhd2 LOC108351305 LOC120103628 LOC120103629 LOC120103631 LOC120103632 Mark3 Nudt14 Pacs2 Pld4 Ppp1r13b Rd3l Siva1 Snora28l1 Tdrd9 Tedc1 Tex22 Tmem121 Tmem179 Tnfaip2 Traf3 Trmt61a Wdr20 Xrcc3 Zfyve21
Number of licking bursts	32.5	1	1	8.3	0	1.00e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1.00e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1.00e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging indifference point 0 sec	11.8	1	0	0	0	1.00e+00	Zfand2b
Patch foraging indifference point AUC	24.2	1	1	8.3	0	1.00e+00	Zfand2b
Indifference point function ln k	54.42	1	1	8.3	0	1.00e+00	Zfand2b
Indifference point function log k	54.42	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 0 sec	10.98	8	1	8.3	0.7	8.15e-03	Brf1 Cep170b Crip2 Jag2 Nudt14 Tedc1 Tmem121 Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 6 sec	13.35	5	1	8.3	0.45	3.67e-01	Crip2 Jag2 Tedc1 Tmem121 Zfand2b
Patch foraging time to switch 0 sec	11.92	49	1	8.3	-1	0.00e+00	Ahnak2 Amn Aspg Bag5 Brf1 Btbd6 C6h14orf180 Cdc42bpb Cdca4 Cep170b Cinp Ckb Clba1 Coa8 Crip1 Crip2 Diras3 Eif5 Exoc3l4 Gpr132 Inf2 Jag2 Kif26a Klc1 Lbhd2 LOC108351305 LOC120103628 LOC120103629 LOC120103631 LOC120103632 Mark3 Nudt14 Pacs2 Pld4 Ppp1r13b Rd3l Siva1 Snora28l1 Tdrd9 Tedc1 Tex22 Tmem121 Tmem179 Tnfaip2 Traf3 Trmt61a Xrcc3 Zfand2b Zfyve21
Patch foraging water rate 12 sec	11.7	26	1	8.3	0.99	1.04e-89	Aspg Bag5 Brf1 C6h14orf180 Cdc42bpb Cinp Coa8 Eif5 Kif26a Klc1 LOC108351305 LOC120103628 LOC120103631 LOC120103632 Ppp1r13b Rd3l Siva1 Tdrd9 Tmem179 Tnfaip2 Traf3 Trmt61a Wdr20 Xrcc3 Zfand2b Zfyve21
Patch foraging water rate 24 sec	12.61	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	8.3	0	1.00e+00	Zfand2b
Locomotor activity	12.38	1	0	0	0	1.00e+00	Zfand2b
Locomotor testing distance	47.2	1	1	8.3	0	1.00e+00	Zfand2b
Locomotor testing rearing	99.51	1	1	8.3	0	1.00e+00	Zfand2b
Light reinforcement 1	19.25	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time number correct	114.79	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time trials on left	106.69	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time mean	36.11	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time mean AUC	33.75	1	1	8.3	0	1.00e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1.00e+00	Zfand2b
Reaction time omissions	46.56	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	8.3	0	1.00e+00	Zfand2b
Std. dev. reaction times	72.92	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time trials completed	106.69	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	8.3	0	1.00e+00	Zfand2b
Conditioned reinforcement - actives	152.54	1	1	8.3	0	1.00e+00	Zfand2b
Conditioned reinforcement - inactives	135.63	1	1	8.3	0	1.00e+00	Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1.00e+00	Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	8.3	0	1.00e+00	Zfand2b
Intermitt. access day 1 inactive lever presses	169.63	1	1	8.3	0	1.00e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	294.26	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access day 1 total infusions	71.42	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access day 15 total infusions	35.39	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access terminal intake (last 3 days)	25.82	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access day 1 locomotion	26.47	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access standard deviation	442.51	1	1	8.3	0	1.00e+00	Zfand2b
Cocaine induced anxiety	125.35	1	1	8.3	0	1.00e+00	Zfand2b
Baseline Anxiety	393.92	1	1	8.3	0	1.00e+00	Zfand2b
Incentive Sensitization - Responses	309.83	1	1	8.3	0	1.00e+00	Zfand2b
Incentive Sensitization - Breakpoint	300.45	1	1	8.3	0	1.00e+00	Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	8.3	0	1.00e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1.00e+00	Zfand2b
Progressive ratio test 2 active lever presses	109.22	1	1	8.3	0	1.00e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	8.3	0	1.00e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	8.3	0	1.00e+00	Zfand2b
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1.00e+00	Zfand2b
Short access day 10 total inactive lever presses	43.04	1	1	8.3	0	1.00e+00	Zfand2b
Short access day 1 locomotion	129.19	1	1	8.3	0	1.00e+00	Zfand2b
Short access day 10 total locomotion	432.47	1	1	8.3	0	1.00e+00	Zfand2b
Short access total locomotion	209.96	1	1	8.3	0	1.00e+00	Zfand2b
Compulsive drug intake	68.39	1	1	8.3	0	1.00e+00	Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1.00e+00	Zfand2b
Number of responses in last shaping day	67.75	1	1	8.3	0	1.00e+00	Zfand2b
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1.00e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1.00e+00	Zfand2b
Time in closed arm before self-admin	44.32	1	1	8.3	0	1.00e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1.00e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	75.62	1	1	8.3	0	1.00e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	8.3	0	1.00e+00	Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1.00e+00	Zfand2b
Area under the delay curve	31.15	1	1	8.3	0	1.00e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	8.3	0	1.00e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	8.3	0	1.00e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1.00e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1.00e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	8.3	0	1.00e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	8.3	0	1.00e+00	Zfand2b
Vertical activity count, locomotor time 1	97.7	1	1	8.3	0	1.00e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1.00e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	8.3	0	1.00e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	8.3	0	1.00e+00	Zfand2b
Distance moved, locomotor task time 2	83.87	1	1	8.3	0	1.00e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1.00e+00	Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1.00e+00	Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	8.3	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	8.3	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	8.3	0	1.00e+00	Zfand2b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	6	0.2	1.69
Adipose	alternative TSS	15	0.4	1.68
Adipose	gene expression	16	0.2	1.56
Adipose	isoform ratio	7	0.2	1.62
Adipose	intron excision ratio	12	0.4	1.56
Adipose	mRNA stability	13	0.3	1.58
BLA	alternative polyA	14	0.6	1.71
BLA	alternative TSS	3	0.2	1.52
BLA	gene expression	12	0.2	1.59
BLA	isoform ratio	14	0.5	1.7
BLA	intron excision ratio	12	0.4	1.61
BLA	mRNA stability	9	0.4	1.72
Brain	alternative polyA	8	0.2	1.58
Brain	alternative TSS	10	0.2	1.53
Brain	gene expression	19	0.2	1.55
Brain	isoform ratio	21	0.4	1.62
Brain	intron excision ratio	34	0.6	1.65
Brain	mRNA stability	11	0.2	1.56
Eye	alternative polyA	0	0	1.65
Eye	alternative TSS	0	0	1.1
Eye	gene expression	1	0.1	1.4
Eye	isoform ratio	1	0.2	1.6
Eye	intron excision ratio	9	1	1.7
Eye	mRNA stability	2	0.6	1.51
IL	alternative polyA	3	0.3	1.63
IL	alternative TSS	0	0	1.58
IL	gene expression	7	0.2	1.58
IL	isoform ratio	7	0.6	1.77
IL	intron excision ratio	7	0.6	1.6
IL	mRNA stability	4	0.3	1.76
LHb	alternative polyA	3	0.3	1.68
LHb	alternative TSS	2	0.3	1.59
LHb	gene expression	7	0.2	1.58
LHb	isoform ratio	8	0.6	1.73
LHb	intron excision ratio	5	0.4	1.6
LHb	mRNA stability	5	0.4	1.71
Liver	alternative polyA	5	0.2	1.71
Liver	alternative TSS	4	0.1	1.51
Liver	gene expression	15	0.2	1.57
Liver	isoform ratio	2	0.1	1.56
Liver	intron excision ratio	11	0.2	1.66
Liver	mRNA stability	8	0.3	1.55
NAcc	alternative polyA	14	0.5	1.7
NAcc	alternative TSS	1	0	1.57
NAcc	gene expression	15	0.2	1.62
NAcc	isoform ratio	13	0.3	1.67
NAcc	intron excision ratio	14	0.3	1.6
NAcc	mRNA stability	10	0.3	1.67
OFC	alternative polyA	4	0.4	1.69
OFC	alternative TSS	1	0.1	1.68
OFC	gene expression	6	0.1	1.54
OFC	isoform ratio	10	0.7	1.83
OFC	intron excision ratio	3	0.3	1.49
OFC	mRNA stability	3	0.2	1.71
PL	alternative polyA	13	0.4	1.77
PL	alternative TSS	11	0.3	1.53
PL	gene expression	20	0.2	1.59
PL	isoform ratio	17	0.4	1.67
PL	intron excision ratio	19	0.3	1.61
PL	mRNA stability	10	0.3	1.63
pVTA	alternative polyA	3	0.2	1.68
pVTA	alternative TSS	0	0	1.46
pVTA	gene expression	7	0.1	1.58
pVTA	isoform ratio	6	0.3	1.7
pVTA	intron excision ratio	10	0.3	1.59
pVTA	mRNA stability	4	0.3	1.64
RMTg	alternative polyA	2	0.3	1.44
RMTg	alternative TSS	0	0	1.55
RMTg	gene expression	2	0.1	1.62
RMTg	isoform ratio	1	0.2	1.36
RMTg	intron excision ratio	0	0	1.38
RMTg	mRNA stability	0	0	1.62