Hub : Traits

Locomotion velocity, hab. session 1

Average velocity of locomotion during first habituation session for males and females [meters/sec]

Tags: Behavior · Motivation · Novelty · Locomotion

Project: p50_shelly_flagel_2014

3 loci · 6 genes with independent associations · 17 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	140610199	142727457	12	2	9.34e-14	7.10e-14	1.00e+00	Ctsc Grm5
2	chr7	29442993	30853534	2	2	1.77e-07	6.27e-08	1.00e+00	Mrpl42 Ube2n
3	chr14	31145547	32675802	3	2	1.19e-08	1.53e-12	2.38e-03	Nmu Pdcl2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Left kidney weight	4.15	2	0	0	0	1.00e+00	LOC108352740 Pdcl2
Liver weight, right	7.14	1	0	0	1	4.66e-03	Grm5
Intraocular pressure	11.89	3	0	0	-0.99	7.74e-21	Ctsc Grm5 LOC102554680
Extensor digitorum longus weight	3.34	1	0	0	0	1.00e+00	Nmu
Mean time between licks in bursts	7.93	3	0	0	1	1.57e-16	Ctsc Grm5 LOC102554680
Patch foraging time to switch 0 sec	8.61	3	0	0	0.99	2.38e-16	Ctsc Grm5 LOC102554680
Patch foraging water rate 0 sec	7.05	1	0	0	0	1.00e+00	Grm5
Patch foraging water rate 12 sec	12.26	3	1	16.7	-0.99	3.62e-17	Ctsc Grm5 LOC102554680
Patch foraging water rate 18 sec	20.17	3	3	50	-0.99	2.21e-24	Ctsc Grm5 LOC102554680
Patch foraging water rate 24 sec	7.66	2	0	0	-1	1.88e-04	Ctsc Grm5
Patch foraging water rate 6 sec	8.01	2	0	0	-1	3.91e-09	Ctsc Grm5
Light reinforcement 1	11.07	3	0	0	1	2.24e-33	Ctsc Grm5 LOC102554680
Light reinforcement 2	21.26	3	3	50	1	6.91e-36	Ctsc Grm5 LOC102554680
Reaction time num false alarms	12.86	3	0	0	1	3.44e-30	Ctsc Grm5 LOC102554680
Reaction time num false alarms AUC	10.37	3	0	0	1	3.88e-26	Ctsc Grm5 LOC102554680
Reaction time false alarm rate	12.88	3	0	0	1	3.67e-26	Ctsc Grm5 LOC102554680
Short access day 1 total infusions	10.36	2	0	0	1	1.35e-11	Ctsc Grm5
Locomotion velocity, session 1	16.27	3	0	0	-1	4.49e-32	Ctsc Grm5 LOC102554680
Locomotion velocity, session 2	8.84	2	0	0	0	1.00e+00	Ctsc Grm5
Locomotion distance, session 3	10.56	2	0	0	-1	1.91e-06	Ctsc Grm5
Stereotopy head waving bouts, day 3	9.54	3	0	0	1	1.42e-21	Ctsc Grm5 LOC102554680
Stereotopy head waving duration, day 3	11.35	3	0	0	0	1.00e+00	LOC108352740 Nmu Pdcl2
Locomotion velocity, session 8	8.8	1	0	0	0	1.00e+00	Ctsc
Total zone transitions, hab. session 1	8.03	5	0	0	-0.44	1.32e-01	Ctsc Grm5 LOC102554680 Mrpl42 Ube2n
Total locomotion distance, hab. session 1	26.07	8	6	100	1	6.52e-42	Ctsc Grm5 LOC102554680 LOC108352740 Mrpl42 Nmu Pdcl2 Ube2n
Total locomotion distance, hab. session 2	29.67	8	3	50	0.99	6.25e-31	Ctsc Grm5 LOC102554680 LOC108352740 Mrpl42 Nmu Pdcl2 Ube2n
Locomotion velocity, hab. session 2	27.77	8	3	50	0.99	2.40e-32	Ctsc Grm5 LOC102554680 LOC108352740 Mrpl42 Nmu Pdcl2 Ube2n
Total locomotion distance, NPP test	34.28	8	4	66.7	0.99	3.08e-32	Ctsc Grm5 LOC102554680 LOC108352740 Mrpl42 Nmu Pdcl2 Ube2n
Locomotion velocity, NPP test	33.15	8	4	66.7	0.99	2.97e-33	Ctsc Grm5 LOC102554680 LOC108352740 Mrpl42 Nmu Pdcl2 Ube2n
Sum of active levers in priming session hrs 5-6	10.8	1	0	0	0	1.00e+00	Grm5
Latency to leave start box in cocaine runway	12.87	1	0	0	1	1.42e-05	Grm5
Na content in liver	10.78	1	0	0	0	1.00e+00	Ctsc

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.42
Adipose	alternative TSS	0	0	1.46
Adipose	gene expression	0	0	1.45
Adipose	isoform ratio	2	0	1.43
Adipose	intron excision ratio	2	0.1	1.4
Adipose	mRNA stability	0	0	1.43
BLA	alternative polyA	0	0	1.35
BLA	alternative TSS	0	0	1.4
BLA	gene expression	3	0	1.45
BLA	isoform ratio	2	0.1	1.43
BLA	intron excision ratio	0	0	1.35
BLA	mRNA stability	0	0	1.46
Brain	alternative polyA	2	0.1	1.44
Brain	alternative TSS	0	0	1.41
Brain	gene expression	2	0	1.46
Brain	isoform ratio	3	0.1	1.41
Brain	intron excision ratio	0	0	1.34
Brain	mRNA stability	2	0	1.42
Eye	alternative polyA	0	0	1.4
Eye	alternative TSS	0	0	1.51
Eye	gene expression	1	0.1	1.43
Eye	isoform ratio	0	0	1.42
Eye	intron excision ratio	0	0	1.28
Eye	mRNA stability	0	0	1.32
IL	alternative polyA	0	0	1.25
IL	alternative TSS	0	0	1.47
IL	gene expression	1	0	1.48
IL	isoform ratio	0	0	1.42
IL	intron excision ratio	0	0	1.26
IL	mRNA stability	0	0	1.45
LHb	alternative polyA	0	0	1.35
LHb	alternative TSS	0	0	1.36
LHb	gene expression	0	0	1.45
LHb	isoform ratio	0	0	1.41
LHb	intron excision ratio	0	0	1.27
LHb	mRNA stability	0	0	1.36
Liver	alternative polyA	0	0	1.44
Liver	alternative TSS	0	0	1.44
Liver	gene expression	2	0	1.42
Liver	isoform ratio	0	0	1.41
Liver	intron excision ratio	0	0	1.38
Liver	mRNA stability	0	0	1.46
NAcc	alternative polyA	0	0	1.47
NAcc	alternative TSS	0	0	1.51
NAcc	gene expression	3	0	1.47
NAcc	isoform ratio	4	0.1	1.44
NAcc	intron excision ratio	0	0	1.39
NAcc	mRNA stability	0	0	1.45
OFC	alternative polyA	0	0	1.46
OFC	alternative TSS	0	0	1.45
OFC	gene expression	1	0	1.48
OFC	isoform ratio	0	0	1.53
OFC	intron excision ratio	0	0	1.28
OFC	mRNA stability	0	0	1.47
PL	alternative polyA	0	0	1.41
PL	alternative TSS	1	0	1.45
PL	gene expression	2	0	1.46
PL	isoform ratio	1	0	1.41
PL	intron excision ratio	0	0	1.36
PL	mRNA stability	0	0	1.42
pVTA	alternative polyA	0	0	1.32
pVTA	alternative TSS	0	0	1.38
pVTA	gene expression	1	0	1.45
pVTA	isoform ratio	0	0	1.41
pVTA	intron excision ratio	0	0	1.28
pVTA	mRNA stability	0	0	1.37
RMTg	alternative polyA	0	0	1.17
RMTg	alternative TSS	0	0	1.27
RMTg	gene expression	0	0	1.38
RMTg	isoform ratio	0	0	1.39
RMTg	intron excision ratio	0	0	1.27
RMTg	mRNA stability	0	0	1.34