Best TWAS P = 1.08e-10 · Best GWAS P= 2.57e-11 conditioned to 2.66e-14
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Brain | Ralyl | isoform ratio | XM_017590727.3 | 0.22 | 1 | 0.08 | 9.1e-08 | 5.25 | 1.52e-07 | 0.01 | FALSE |
| Brain | Ralyl | isoform ratio | XM_039101954.2 | 0.36 | 22 | 0.17 | 6.6e-16 | -5.22 | 1.78e-07 | 0.03 | FALSE |
| Brain | Ralyl | intron excision ratio | chr2_89538934_89571226 | 0.05 | 2733 | 0.01 | 1.6e-02 | -5.6 | 2.08e-08 | 0.29 | FALSE |
| IC | Ralyl | alternative TSS | XM_039101954.2 | 0.57 | 38 | 0.3 | 2.6e-13 | -5.51 | 3.52e-08 | 0.08 | FALSE |
| IC | Ralyl | alternative TSS | NM_001393770.1 | 0.19 | 2034 | 0.12 | 1.3e-05 | 5.36 | 8.29e-08 | 0.22 | FALSE |
| IC | Ralyl | alternative TSS | XM_039101954.2 | 0.58 | 32 | 0.33 | 2.7e-14 | -5.74 | 9.63e-09 | 0.23 | FALSE |
| LHb | Ralyl | alternative TSS | NM_001024978.2 | 0.31 | 1 | 0.03 | 6.3e-02 | 6.16 | 7.13e-10 | 0.05 | FALSE |
| LHb | Ralyl | alternative TSS | XM_008760853.4 | 0.22 | 13 | 0.05 | 3.0e-02 | 5.49 | 3.98e-08 | 0.28 | FALSE |
| LHb | Ralyl | alternative TSS | XM_039101954.2 | 0.25 | 53 | 0.08 | 6.2e-03 | -5.45 | 5.04e-08 | 0.17 | FALSE |
| LHb | Ralyl | alternative TSS | XM_063281532.1 | 0.31 | 1 | 0.06 | 1.5e-02 | -6.46 | 1.08e-10 | 0.06 | TRUE |
| LHb | Ralyl | alternative TSS | XM_008760853.4 | 0.22 | 17 | 0.05 | 2.8e-02 | 5.49 | 3.98e-08 | 0.28 | FALSE |
| LHb | Ralyl | alternative TSS | XM_039101954.2 | 0.24 | 65 | 0.08 | 5.9e-03 | -5.41 | 6.15e-08 | 0.17 | TRUE |
| LHb | Ralyl | alternative TSS | XM_063281532.1 | 0.3 | 2733 | 0.04 | 4.7e-02 | -5.87 | 4.36e-09 | 0.36 | FALSE |
| LHb | Ralyl | gene expression | Ralyl | 0.62 | 1 | 0.11 | 1.1e-03 | 5.48 | 4.28e-08 | 0.05 | FALSE |
| LHb | Ralyl | isoform ratio | XM_008760853.4 | 0.26 | 2 | 0.1 | 2.2e-03 | 5.88 | 4.15e-09 | 0.28 | TRUE |
| LHb | Ralyl | mRNA stability | Ralyl | 0.37 | 4 | 0.13 | 5.0e-04 | 5.39 | 7.22e-08 | 0.48 | FALSE |
| OFC | Ralyl | gene expression | Ralyl | 0.44 | 73 | 0.12 | 8.0e-04 | -5.23 | 1.70e-07 | 0.17 | FALSE |
| OFC | Ralyl | isoform ratio | XM_039101954.2 | 0.42 | 14 | 0.17 | 6.9e-05 | -5.3 | 1.14e-07 | 0.22 | FALSE |
| OFC | Ralyl | intron excision ratio | chr2_89446704_89456870 | 0.35 | 2 | 0.13 | 6.5e-04 | 6.27 | 3.58e-10 | 0.23 | TRUE |
| OFC | Ralyl | intron excision ratio | chr2_89571301_89658335 | 0.22 | 14 | 0.09 | 3.8e-03 | 5.37 | 8.09e-08 | 0.28 | FALSE |
| pVTA | Ralyl | alternative TSS | XM_017590724.2 | 0.08 | 2732 | 0.07 | 2.0e-06 | -6.16 | 7.36e-10 | 0.67 | FALSE |
| pVTA | Ralyl | alternative TSS | XM_063281535.1 | 0.03 | 1 | 0.01 | 2.9e-02 | -5.65 | 1.64e-08 | 0.03 | FALSE |
| pVTA | Ralyl | alternative TSS | NM_001393770.1 | 0.14 | 2732 | 0.14 | 4.4e-11 | 5.73 | 9.88e-09 | 0.04 | FALSE |
| pVTA | Ralyl | alternative TSS | XM_017590724.2 | 0.08 | 2732 | 0.07 | 3.2e-06 | -6.12 | 9.25e-10 | 0.66 | FALSE |