| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000004518 | 0.0430 | 0.0370 | 2.1e-05 | 0.032 | 0.024 | 0.016 | 0.024 | 1.6e-04 | 9.5e-04 | 5.3e-03 | 1.0e-03 |
| 2 | BLA | gene expression | ENSRNOG00000004518 | 0.1324 | 0.1230 | 9.9e-03 | 0.002 | 0.012 | -0.003 | -0.003 | 2.4e-01 | 7.2e-02 | 4.7e-01 | 4.9e-01 |
| 3 | BLA | mRNA stability | ENSRNOG00000004518 | 0.0650 | 0.0520 | 2.4e-03 | 0.046 | 0.041 | 0.045 | 0.048 | 1.7e-03 | 3.1e-03 | 2.0e-03 | 1.4e-03 |
| 4 | Brain | gene expression | ENSRNOG00000004518 | 0.0400 | 0.0300 | 2.5e-04 | 0.030 | 0.037 | 0.033 | 0.030 | 8.1e-04 | 2.0e-04 | 4.2e-04 | 7.9e-04 |
| 5 | Brain | isoform ratio | ENSRNOT00000082974 | 0.0336 | 0.0350 | 5.0e-03 | 0.017 | 0.015 | 0.002 | 0.011 | 8.5e-03 | 1.5e-02 | 2.0e-01 | 3.0e-02 |
| 6 | Brain | intron excision ratio | chr10:83007534:83008770 | 0.0343 | 0.0275 | 6.9e-04 | 0.018 | 0.022 | 0.007 | 0.013 | 8.0e-03 | 3.5e-03 | 6.9e-02 | 1.9e-02 |
| 7 | Brain | intron excision ratio | chr10:83008403:83008770 | 0.0360 | 0.0291 | 5.7e-04 | 0.018 | 0.024 | 0.007 | 0.015 | 7.4e-03 | 2.4e-03 | 7.1e-02 | 1.4e-02 |
| 8 | Brain | mRNA stability | ENSRNOG00000004518 | 0.0828 | 0.0608 | 2.4e-07 | 0.061 | 0.077 | 0.069 | 0.076 | 2.4e-06 | 1.2e-07 | 5.3e-07 | 1.5e-07 |
| 9 | NAcc | mRNA stability | ENSRNOG00000004518 | 0.0416 | 0.0334 | 1.4e-03 | 0.039 | 0.032 | 0.028 | 0.032 | 6.8e-04 | 1.9e-03 | 3.5e-03 | 1.9e-03 |
| 10 | PL | gene expression | ENSRNOG00000004518 | 0.0443 | 0.0379 | 1.9e-03 | 0.024 | 0.026 | 0.022 | 0.020 | 5.4e-03 | 4.1e-03 | 8.3e-03 | 1.0e-02 |
| 11 | PL | mRNA stability | ENSRNOG00000004518 | 0.3059 | 0.1705 | 6.0e-05 | 0.060 | 0.042 | 0.039 | 0.043 | 2.4e-05 | 3.9e-04 | 5.5e-04 | 3.0e-04 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pavlov. Cond. magazine entry number | 13.6 | 17.0 | 17.9 | -4.2 | 4.2 | -3.9 | 4.2 | 4.2 | -4.2 | 4.2 | -4.2 | -3.9 | 4.1 | -4.2 |
| Pavlov. Cond. magazine entry latency | 10.9 | 14.0 | 14.3 | 3.8 | -3.8 | 3.7 | -3.8 | -3.7 | 3.8 | -3.8 | 3.8 | 3.7 | -3.7 | 3.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 10.3 | 13.0 | 13.2 | 3.6 | -3.6 | 3.5 | -3.6 | -3.6 | 3.6 | -3.6 | 3.6 | 3.5 | -3.6 | 3.6 |
| Pavlov. Cond. response bias | 10.2 | 12.5 | 13.1 | 3.6 | -3.5 | 3.4 | -3.6 | -3.5 | 3.5 | -3.5 | 3.6 | 3.4 | -3.5 | 3.6 |
| Pavlov. Cond. index score | 9.1 | 11.7 | 11.9 | 3.5 | -3.4 | 3.3 | -3.4 | -3.4 | 3.4 | -3.4 | 3.4 | 3.3 | -3.4 | 3.5 |
| Pavlov. Cond. change in total contacts | 8.9 | 9.5 | 11.0 | 3.3 | -3.2 | 2.8 | -3.1 | -3.1 | 3.0 | -3.0 | 3.1 | 2.9 | -3.0 | 3.3 |
| Extensor digitorum longus weight | 8.6 | 34.4 | 38.8 | -6.2 | 5.8 | -5.7 | 5.9 | 5.7 | -5.8 | 5.8 | -5.8 | -5.7 | 5.8 | -6.2 |
| Locomotion velocity, session 8 | 7.4 | 8.9 | 9.8 | -3.1 | 3.0 | -2.8 | 3.0 | 3.0 | -3.0 | 3.0 | -3.0 | -2.8 | 3.0 | -3.1 |
| Pavlov. Cond. latency score | 7.1 | 9.1 | 9.4 | 3.0 | -3.1 | 2.9 | -3.0 | -3.1 | 3.0 | -3.0 | 3.1 | 2.9 | -3.0 | 3.0 |
| Bone: cortical apparent density | 6.2 | 8.0 | 9.6 | 3.1 | -2.9 | 2.5 | -2.8 | -2.8 | 2.8 | -2.8 | 2.9 | 2.6 | -2.8 | 3.1 |
| Bone: cortical tissue density | 6.2 | 8.0 | 9.7 | 3.1 | -2.9 | 2.5 | -2.8 | -2.8 | 2.8 | -2.8 | 2.9 | 2.6 | -2.8 | 3.1 |
| Body weight | 6.0 | 25.3 | 27.1 | -4.8 | 5.2 | -4.8 | 5.1 | 5.2 | -5.1 | 5.1 | -5.2 | -4.8 | 5.1 | -4.8 |
| Locomotor testing rearing | 5.9 | 9.3 | 10.6 | 3.3 | -3.0 | 3.1 | -3.1 | -2.8 | 3.0 | -3.0 | 3.0 | 3.1 | -3.0 | 3.3 |
| Locomotion in novel chamber | 5.5 | 6.8 | 10.2 | 2.7 | -3.2 | 2.0 | -2.5 | -2.9 | 2.5 | -2.5 | 2.8 | 2.0 | -2.6 | 2.7 |
| Bone: trabecular number | 5.3 | 8.2 | 9.2 | 2.8 | -3.0 | 2.7 | -2.9 | -3.0 | 2.9 | -2.9 | 3.0 | 2.7 | -2.9 | 2.8 |
| Bone: cortical thickness | 5.2 | 6.1 | 6.4 | 2.4 | -2.5 | 2.4 | -2.5 | -2.4 | 2.5 | -2.5 | 2.5 | 2.5 | -2.5 | 2.4 |
| Length without tail | 4.8 | 10.5 | 12.4 | -3.0 | 3.5 | -3.0 | 3.3 | 3.5 | -3.3 | 3.3 | -3.4 | -3.0 | 3.3 | -3.0 |
| Delay discounting total patch changes 12 sec | 4.8 | 6.4 | 8.2 | 2.9 | -2.6 | 2.3 | -2.5 | -2.4 | 2.5 | -2.5 | 2.6 | 2.1 | -2.5 | 2.9 |
| Length with tail | 4.6 | 16.8 | 18.9 | -3.4 | 4.1 | -4.3 | 4.2 | 4.3 | -4.3 | 4.3 | -4.2 | -4.3 | 4.3 | -3.4 |
| Delta time in closed arm before/after self-admin | 3.7 | 3.6 | 3.9 | -1.9 | 1.9 | -1.7 | 1.9 | 1.9 | -2.0 | 2.0 | -2.0 | -1.7 | 1.9 | -1.9 |
| Locomotion distance, session 1 | 3.5 | 4.5 | 5.5 | -1.4 | 2.1 | -2.3 | 2.2 | 2.4 | -2.3 | 2.3 | -2.2 | -2.3 | 2.3 | -1.4 |
| Stereotopy head waving bouts, day 3 | 3.5 | 4.2 | 4.8 | 1.6 | -2.0 | 2.2 | -2.1 | -2.1 | 2.1 | -2.1 | 2.1 | 2.2 | -2.1 | 1.6 |
| Intermitt. access day 15 inactive lever presses | 3.4 | 3.7 | 6.1 | 2.5 | -2.0 | 1.5 | -1.8 | -2.0 | 1.8 | -1.8 | 1.9 | 1.4 | -1.8 | 2.5 |
| Cocaine response after cond. not corrected | 3.3 | 3.7 | 4.6 | 1.1 | -2.1 | 1.8 | -2.0 | -2.2 | 2.1 | -2.1 | 2.1 | 1.9 | -2.1 | 1.1 |
| Pavlov. Cond. lever latency | 3.2 | 4.0 | 4.6 | -2.1 | 2.0 | -1.9 | 2.0 | 2.0 | -2.0 | 2.0 | -2.0 | -1.9 | 2.0 | -2.1 |
| Time in open arm before self-admin | 3.2 | 3.5 | 3.8 | -1.8 | 1.8 | -1.8 | 1.9 | 2.0 | -1.9 | 1.9 | -1.9 | -1.9 | 1.9 | -1.8 |
| Ambulatory time after self-admin | 3.2 | 3.5 | 4.6 | -1.8 | 2.0 | -1.6 | 1.9 | 2.2 | -1.9 | 1.9 | -2.0 | -1.6 | 1.9 | -1.8 |
| Se content in liver | 3.2 | 3.9 | 7.5 | 2.7 | -2.0 | 1.5 | -1.8 | -1.8 | 1.8 | -1.8 | 1.9 | 1.5 | -1.7 | 2.7 |
| Heart weight | 3.1 | 4.4 | 5.6 | -1.8 | 2.4 | -1.8 | 2.1 | 2.3 | -2.2 | 2.2 | -2.3 | -1.9 | 2.2 | -1.8 |
| Bone: connectivity density | 3.0 | 4.7 | 5.5 | 2.2 | -2.3 | 2.0 | -2.2 | -2.2 | 2.2 | -2.2 | 2.3 | 2.0 | -2.1 | 2.2 |
| Delta time to tail flick, test, before/after SA | 3.0 | 2.7 | 6.0 | 2.4 | -1.8 | 1.0 | -1.4 | -1.7 | 1.4 | -1.4 | 1.6 | 0.8 | -1.4 | 2.4 |
| Locomotor testing distance | 2.9 | 4.9 | 6.8 | 1.8 | -2.0 | 2.6 | -2.3 | -2.2 | 2.3 | -2.3 | 2.2 | 2.5 | -2.3 | 1.8 |
| Baseline Anxiety | 2.9 | 3.1 | 3.6 | 1.3 | -1.8 | 1.9 | -1.8 | -1.9 | 1.8 | -1.8 | 1.8 | 1.9 | -1.9 | 1.3 |
| Short access day 1 locomotion | 2.8 | 3.0 | 4.7 | 2.2 | -1.7 | 1.6 | -1.7 | -1.6 | 1.6 | -1.6 | 1.7 | 1.5 | -1.6 | 2.2 |
| Pavlov. Cond. lever contacts | 2.8 | 3.3 | 3.5 | 1.9 | -1.8 | 1.7 | -1.8 | -1.8 | 1.8 | -1.8 | 1.8 | 1.8 | -1.8 | 1.9 |
| Run reversals in cocaine runway, females | 2.6 | 2.5 | 3.0 | -1.7 | 1.7 | -1.4 | 1.6 | 1.6 | -1.6 | 1.6 | -1.7 | -1.3 | 1.6 | -1.7 |
| Latency to leave start box in cocaine runway | 2.6 | 2.8 | 4.2 | -0.8 | 1.7 | -2.0 | 1.8 | 1.6 | -1.8 | 1.8 | -1.7 | -2.0 | 1.8 | -0.8 |
| Latency to leave start box in cocaine runway, F | 2.4 | 2.6 | 3.7 | -1.1 | 1.6 | -1.9 | 1.7 | 1.5 | -1.7 | 1.7 | -1.6 | -1.9 | 1.7 | -1.1 |
| Bone: apparent density | 2.3 | 3.8 | 4.8 | 1.9 | -2.2 | 1.7 | -1.9 | -2.1 | 2.0 | -2.0 | 2.1 | 1.7 | -1.9 | 1.9 |
| Light reinforcement 1 | 2.2 | 4.1 | 6.4 | 2.5 | -1.9 | 2.0 | -2.0 | -1.7 | 1.9 | -1.9 | 1.9 | 1.9 | -1.9 | 2.5 |
| Condit. Reinf. inactive responses | 2.2 | 2.7 | 3.5 | 1.6 | -1.4 | 1.9 | -1.7 | -1.4 | 1.7 | -1.7 | 1.6 | 1.9 | -1.7 | 1.6 |
| Cocaine induced anxiety | 2.2 | 2.5 | 2.6 | -1.5 | 1.5 | -1.6 | 1.6 | 1.6 | -1.6 | 1.6 | -1.6 | -1.6 | 1.6 | -1.5 |
| Total zone transitions, hab. session 1 | 2.2 | 3.1 | 3.8 | -1.5 | 1.7 | -1.9 | 1.8 | 1.8 | -1.8 | 1.8 | -1.8 | -1.9 | 1.8 | -1.5 |
| Bone: endosteal estimation | 2.2 | 4.7 | 5.6 | -2.1 | 2.3 | -1.9 | 2.2 | 2.4 | -2.2 | 2.2 | -2.3 | -1.9 | 2.2 | -2.1 |
| Delay disc. indifference point, 2s delay | 2.2 | 2.4 | 2.9 | 1.1 | -1.6 | 1.6 | -1.7 | -1.7 | 1.7 | -1.7 | 1.6 | 1.6 | -1.7 | 1.1 |
| Left kidney weight | 2.1 | 6.0 | 7.6 | -1.7 | 2.4 | -2.7 | 2.6 | 2.5 | -2.6 | 2.6 | -2.5 | -2.8 | 2.6 | -1.7 |
| Cocaine response after cond. corrected | 2.1 | 2.3 | 3.3 | 1.0 | -1.8 | 1.3 | -1.6 | -1.8 | 1.6 | -1.7 | 1.7 | 1.3 | -1.7 | 1.0 |
| Zn content in liver | 2.1 | 2.4 | 4.1 | 2.0 | -1.4 | 1.5 | -1.5 | -1.3 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | 2.0 |
| Delay discounting total patch changes 24 sec | 2.0 | 2.5 | 3.8 | 1.4 | -2.0 | 1.1 | -1.6 | -1.8 | 1.6 | -1.7 | 1.8 | 1.0 | -1.7 | 1.4 |
| Short access day 10 total locomotion | 2.0 | 2.2 | 2.9 | 1.3 | -1.4 | 1.7 | -1.5 | -1.5 | 1.5 | -1.5 | 1.4 | 1.6 | -1.5 | 1.3 |
| Bone: marrow area | 2.0 | 4.4 | 5.3 | -2.0 | 2.3 | -1.8 | 2.1 | 2.3 | -2.1 | 2.1 | -2.2 | -1.9 | 2.1 | -2.0 |
| Distance traveled after self-admin | 1.9 | 2.1 | 3.0 | -1.4 | 1.7 | -1.0 | 1.4 | 1.7 | -1.4 | 1.4 | -1.6 | -1.0 | 1.5 | -1.4 |
| Short access day 1 total inactive lever presses | 1.8 | 2.0 | 3.9 | 2.0 | -1.0 | 1.4 | -1.3 | -1.1 | 1.3 | -1.3 | 1.2 | 1.3 | -1.2 | 2.0 |
| Bone: endosteal perimeter | 1.8 | 3.7 | 4.5 | -1.5 | 2.1 | -1.8 | 2.0 | 2.1 | -2.0 | 2.0 | -2.1 | -1.8 | 2.0 | -1.5 |
| Time >=10cm from walls, locomotor time 2 | 1.8 | 1.9 | 2.5 | 0.9 | -1.5 | 1.4 | -1.5 | -1.6 | 1.5 | -1.5 | 1.5 | 1.1 | -1.6 | 0.9 |
| Delay discounting total patch changes 6 sec | 1.7 | 2.5 | 4.0 | 2.0 | -1.8 | 1.2 | -1.5 | -1.4 | 1.5 | -1.5 | 1.7 | 1.2 | -1.5 | 2.0 |
| Pavlov. Cond. intertrial magazine entries | 1.7 | 2.3 | 2.9 | -1.7 | 1.5 | -1.3 | 1.5 | 1.6 | -1.4 | 1.4 | -1.5 | -1.4 | 1.4 | -1.7 |
| BMI with tail | 1.6 | 5.3 | 5.8 | -2.4 | 2.4 | -2.2 | 2.3 | 2.3 | -2.3 | 2.3 | -2.4 | -2.0 | 2.3 | -2.4 |
| Intraocular pressure | 1.6 | 2.3 | 3.8 | -1.9 | 1.7 | -1.1 | 1.4 | 1.5 | -1.4 | 1.4 | -1.5 | -1.2 | 1.3 | -1.9 |
| Locomotion distance, session 8 | 1.6 | 2.4 | 2.7 | -1.4 | 1.5 | -1.6 | 1.6 | 1.6 | -1.6 | 1.6 | -1.5 | -1.7 | 1.6 | -1.4 |
| Incentive salience index mean | 1.6 | 1.9 | 2.9 | 1.7 | -1.4 | 1.3 | -1.3 | -1.3 | 1.3 | -1.3 | 1.3 | 1.3 | -1.3 | 1.7 |
| Pavlov. Cond. intertrial magazine entries | 1.6 | 1.9 | 2.2 | -1.5 | 1.3 | -1.4 | 1.4 | 1.3 | -1.4 | 1.4 | -1.4 | -1.4 | 1.4 | -1.5 |
| Indifference point 0 sec | 1.5 | 2.3 | 2.9 | 1.7 | -1.6 | 1.4 | -1.6 | -1.4 | 1.5 | -1.5 | 1.6 | 1.4 | -1.5 | 1.7 |
| Degree of sensitization stereotypy | 1.5 | 1.7 | 2.2 | 0.8 | -1.4 | 1.2 | -1.4 | -1.5 | 1.4 | -1.4 | 1.4 | 1.2 | -1.4 | 0.8 |
| Bone: cortical thickness | 1.5 | 2.5 | 3.6 | 1.2 | -1.9 | 1.3 | -1.6 | -1.9 | 1.7 | -1.7 | 1.8 | 1.4 | -1.7 | 1.2 |
| Mean time between licks in bursts | 1.4 | 1.9 | 2.1 | -1.3 | 1.4 | -1.3 | 1.4 | 1.3 | -1.4 | 1.4 | -1.4 | -1.3 | 1.4 | -1.3 |
| Delta distance traveled before/after self-admin | 1.4 | 1.4 | 2.5 | -1.6 | 1.2 | -0.9 | 1.1 | 1.3 | -1.1 | 1.1 | -1.1 | -1.0 | 1.1 | -1.6 |
| Fe content in liver | 1.4 | 1.6 | 1.9 | -1.0 | 1.2 | -1.4 | 1.3 | 1.3 | -1.3 | 1.3 | -1.3 | -1.4 | 1.3 | -1.0 |
| Tibialis anterior weight | 1.3 | 4.6 | 5.3 | -2.3 | 2.0 | -2.2 | 2.2 | 2.0 | -2.1 | 2.1 | -2.1 | -2.2 | 2.1 | -2.3 |
| Conditioned reinforcement - inactives | 1.3 | 1.5 | 2.2 | 1.5 | -0.9 | 1.4 | -1.2 | -1.0 | 1.2 | -1.1 | 1.1 | 1.3 | -1.1 | 1.5 |
| Intermitt. access escalation Index | 1.3 | 1.2 | 3.5 | -1.9 | 0.8 | -0.8 | 0.9 | 0.7 | -0.8 | 0.8 | -0.9 | -0.8 | 0.8 | -1.9 |
| Novel to familiar place preference ratio | 1.3 | 1.4 | 1.6 | -1.1 | 1.1 | -1.3 | 1.2 | 1.1 | -1.2 | 1.2 | -1.2 | -1.3 | 1.2 | -1.1 |
| Rb content in liver | 1.3 | 1.6 | 2.1 | 1.5 | -1.2 | 1.2 | -1.3 | -1.2 | 1.2 | -1.2 | 1.2 | 1.2 | -1.2 | 1.5 |
| Reaction time false alarm rate | 1.2 | 1.6 | 2.1 | 1.1 | -1.2 | 1.3 | -1.3 | -1.2 | 1.3 | -1.3 | 1.3 | 1.5 | -1.3 | 1.1 |
| Conditioned reinforcement - actives | 1.2 | 1.2 | 2.0 | 0.5 | -0.8 | 1.3 | -1.2 | -1.0 | 1.2 | -1.2 | 1.0 | 1.4 | -1.2 | 0.5 |
| Intermitt. access day 1 inactive lever presses | 1.2 | 1.3 | 3.6 | 1.9 | -0.7 | 1.1 | -1.0 | -0.6 | 0.9 | -0.9 | 0.8 | 1.0 | -0.8 | 1.9 |
| Condit. Reinf. lever presses | 1.2 | 1.6 | 2.1 | 1.5 | -1.3 | 1.1 | -1.2 | -1.2 | 1.2 | -1.2 | 1.2 | 1.1 | -1.2 | 1.5 |
| Time to tail flick, test, before self-admin | 1.2 | 1.2 | 3.2 | -1.8 | 1.1 | -0.6 | 0.9 | 1.1 | -0.9 | 0.9 | -1.0 | -0.6 | 0.9 | -1.8 |
| Rest time, locomotor task time 2 | 1.2 | 1.4 | 1.6 | -1.2 | 1.3 | -1.1 | 1.1 | 1.3 | -1.2 | 1.2 | -1.2 | -1.2 | 1.2 | -1.2 |
| Co content in liver | 1.2 | 1.4 | 1.8 | -0.6 | 1.2 | -1.3 | 1.3 | 1.3 | -1.3 | 1.3 | -1.2 | -1.3 | 1.3 | -0.6 |
| Times rat made contact with spout | 1.1 | 1.2 | 1.9 | 1.1 | -1.4 | 0.8 | -1.1 | -1.3 | 1.1 | -1.1 | 1.2 | 1.0 | -1.1 | 1.1 |
| Condit. Reinf. active responses | 1.1 | 1.5 | 2.2 | 1.5 | -1.1 | 1.3 | -1.2 | -1.0 | 1.2 | -1.2 | 1.1 | 1.3 | -1.2 | 1.5 |
| Condit. Reinf. lever reinforcers received | 1.1 | 1.5 | 2.4 | 1.6 | -1.1 | 1.2 | -1.2 | -0.9 | 1.1 | -1.1 | 1.1 | 1.3 | -1.1 | 1.6 |
| Conditioned locomotion | 1.1 | 1.3 | 1.6 | 0.9 | -1.0 | 1.2 | -1.2 | -1.2 | 1.2 | -1.2 | 1.1 | 1.2 | -1.2 | 0.9 |
| Incentive Sensitization - Responses | 1.1 | 1.1 | 1.4 | 1.1 | -1.2 | 0.9 | -1.1 | -1.2 | 1.1 | -1.1 | 1.1 | 0.9 | -1.1 | 1.1 |
| Incentive Sensitization - Breakpoint | 1.1 | 1.1 | 1.4 | 1.1 | -1.2 | 0.8 | -1.0 | -1.2 | 1.0 | -1.0 | 1.1 | 0.8 | -1.1 | 1.1 |
| Progressive ratio test 1 active lever presses | 1.1 | 1.1 | 1.4 | 0.7 | -1.2 | 1.0 | -1.1 | -1.1 | 1.2 | -1.2 | 1.2 | 1.0 | -1.2 | 0.7 |
| Progressive ratio test 2 active lever presses | 1.1 | 1.2 | 1.3 | 1.0 | -1.1 | 1.0 | -1.1 | -1.1 | 1.1 | -1.1 | 1.1 | 1.0 | -1.1 | 1.0 |
| Bone: final force | 1.1 | 1.8 | 2.2 | 0.9 | -1.4 | 1.4 | -1.4 | -1.4 | 1.4 | -1.5 | 1.4 | 1.5 | -1.5 | 0.9 |
| Bone: post-yield work | 1.1 | 1.5 | 2.2 | -1.5 | 1.3 | -0.9 | 1.2 | 1.2 | -1.2 | 1.2 | -1.2 | -0.9 | 1.2 | -1.5 |
| Time in closed arm before self-admin | 1.1 | 1.3 | 1.4 | 1.2 | -1.1 | 1.1 | -1.2 | -0.9 | 1.2 | -1.2 | 1.1 | 1.2 | -1.1 | 1.2 |
| Delay disc. indifference point, 0s delay | 1.1 | 1.2 | 1.5 | 0.9 | -1.2 | 1.0 | -1.2 | -1.1 | 1.2 | -1.2 | 1.2 | 0.9 | -1.2 | 0.9 |
| Food consumed during 24 hour testing period | 1.0 | 1.2 | 1.8 | -1.1 | 0.8 | -1.3 | 1.1 | 1.0 | -1.1 | 1.1 | -1.0 | -1.3 | 1.1 | -1.1 |
| Delay discounting total patch changes 0 sec | 1.0 | 1.6 | 2.1 | 1.4 | -1.4 | 1.1 | -1.3 | -1.2 | 1.2 | -1.2 | 1.3 | 1.0 | -1.2 | 1.4 |
| Delay discounting water rate 6 sec | 1.0 | 1.4 | 2.2 | 1.5 | -1.1 | 1.1 | -1.2 | -1.0 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.5 |
| Pavlov. Cond. response bias | 1.0 | 1.4 | 1.8 | 1.4 | -1.2 | 1.0 | -1.1 | -1.2 | 1.1 | -1.1 | 1.2 | 1.0 | -1.1 | 1.4 |
| Progressive ratio test 1 breakpoint | 1.0 | 1.0 | 1.3 | 0.6 | -1.0 | 1.1 | -1.1 | -1.0 | 1.2 | -1.2 | 1.1 | 1.1 | -1.2 | 0.6 |
| Progressive ratio test 1 inactive lever presses | 1.0 | 1.1 | 1.6 | 1.2 | -0.9 | 1.1 | -1.0 | -0.9 | 1.0 | -1.0 | 1.0 | 1.0 | -1.0 | 1.2 |
| Total sessions with >9 infusions | 1.0 | 1.0 | 1.7 | 1.3 | -0.8 | 1.1 | -0.9 | -0.8 | 1.0 | -0.9 | 0.9 | 1.0 | -0.9 | 1.3 |
| Bone: trabecular spacing | 1.0 | 1.3 | 1.6 | -1.3 | 1.3 | -0.9 | 1.1 | 1.1 | -1.1 | 1.1 | -1.2 | -1.0 | 1.1 | -1.3 |
| Extinction: sum of active levers before priming | 1.0 | 1.0 | 1.8 | -1.4 | 1.1 | -0.5 | 0.9 | 0.9 | -0.9 | 0.9 | -1.0 | -0.6 | 0.9 | -1.4 |
| Total resting periods, locomotor time 1 | 1.0 | 1.2 | 1.9 | -1.4 | 1.2 | -0.9 | 0.9 | 1.1 | -0.9 | 0.9 | -1.1 | -0.9 | 0.9 | -1.4 |
| Tail length | 0.9 | 2.6 | 4.1 | -0.8 | 1.4 | -1.9 | 1.7 | 1.7 | -1.8 | 1.8 | -1.6 | -2.0 | 1.8 | -0.8 |
| Tibia length | 0.9 | 2.6 | 4.2 | -2.1 | 1.5 | -1.5 | 1.6 | 1.4 | -1.5 | 1.5 | -1.5 | -1.4 | 1.5 | -2.1 |
| Reaction time omissions | 0.9 | 1.2 | 1.7 | 1.3 | -1.1 | 0.9 | -1.0 | -1.1 | 1.0 | -1.0 | 1.1 | 1.0 | -1.0 | 1.3 |
| Progressive ratio test 2 breakpoint | 0.9 | 1.0 | 1.2 | 0.8 | -1.0 | 1.0 | -1.1 | -1.1 | 1.1 | -1.1 | 1.0 | 1.0 | -1.1 | 0.8 |
| Stereotopy head waving bouts, day 7 | 0.9 | 1.0 | 1.4 | 0.6 | -1.2 | 0.9 | -1.0 | -1.2 | 1.1 | -1.1 | 1.1 | 0.9 | -1.1 | 0.6 |
| Novelty place preference | 0.9 | 0.9 | 1.0 | -1.0 | 0.9 | -0.9 | 1.0 | 0.9 | -0.9 | 0.9 | -0.9 | -0.9 | 0.9 | -1.0 |
| Bone: final moment | 0.9 | 1.4 | 1.8 | 0.7 | -1.2 | 1.3 | -1.3 | -1.3 | 1.3 | -1.3 | 1.3 | 1.3 | -1.3 | 0.7 |
| Breakpoint value in progressive ratio session | 0.9 | 1.0 | 1.7 | -0.1 | 1.3 | -0.9 | 1.1 | 1.3 | -1.1 | 1.1 | -1.2 | -1.0 | 1.2 | -0.1 |
| Mn content in liver | 0.9 | 1.1 | 2.4 | 1.6 | -1.1 | 0.6 | -0.9 | -0.8 | 0.9 | -0.9 | 1.0 | 0.7 | -0.8 | 1.6 |
| Light reinforcement 2 | 0.8 | 1.1 | 2.0 | 1.4 | -1.0 | 1.0 | -1.0 | -0.9 | 1.0 | -1.0 | 1.0 | 1.1 | -0.9 | 1.4 |
| Reaction time num false alarms | 0.8 | 1.0 | 1.3 | 0.9 | -1.0 | 1.0 | -1.1 | -1.0 | 1.0 | -1.0 | 1.0 | 1.1 | -1.0 | 0.9 |
| Cocaine response before conditioning | 0.8 | 0.9 | 1.7 | 0.3 | -0.7 | 1.3 | -1.0 | -0.9 | 1.1 | -1.1 | 0.9 | 1.3 | -1.1 | 0.3 |
| Pavlov. Cond. lever contacts | 0.8 | 1.1 | 1.2 | 1.0 | -1.1 | 1.0 | -1.0 | -1.1 | 1.0 | -1.0 | 1.1 | 1.1 | -1.0 | 1.0 |
| Locomotion distance, session 2 | 0.8 | 1.2 | 1.9 | -0.2 | 0.9 | -1.4 | 1.1 | 1.2 | -1.2 | 1.2 | -1.1 | -1.4 | 1.2 | -0.2 |
| Locomotion velocity, session 7 | 0.8 | 0.9 | 1.2 | -1.0 | 1.1 | -0.7 | 0.9 | 1.0 | -0.9 | 0.9 | -1.0 | -0.7 | 0.9 | -1.0 |
| Delay disc. indifference point, 16s delay | 0.8 | 0.8 | 0.9 | 0.9 | -0.8 | 0.9 | -0.9 | -0.9 | 0.9 | -0.9 | 0.9 | 0.9 | -0.9 | 0.9 |
| Locomotion in novel chamber post-restriction | 0.8 | 1.0 | 1.3 | 1.1 | -1.1 | 0.8 | -0.9 | -1.0 | 0.9 | -0.9 | 1.0 | 0.9 | -0.9 | 1.1 |
| Parametrial fat weight | 0.7 | 1.4 | 3.2 | 1.8 | -0.8 | 1.3 | -1.1 | -0.7 | 1.0 | -1.0 | 0.9 | 1.2 | -1.0 | 1.8 |
| Reaction time number correct | 0.7 | 1.0 | 1.2 | -1.0 | 1.0 | -1.0 | 1.1 | 0.9 | -1.1 | 1.1 | -1.1 | -1.1 | 1.0 | -1.0 |
| Reaction time trials correct on left | 0.7 | 1.0 | 1.2 | -1.0 | 1.0 | -1.0 | 1.1 | 0.9 | -1.1 | 1.1 | -1.1 | -1.1 | 1.0 | -1.0 |
| Reaction time trials on left | 0.7 | 1.0 | 1.1 | -0.9 | 1.0 | -1.0 | 1.1 | 0.9 | -1.0 | 1.0 | -1.0 | -1.1 | 1.0 | -0.9 |
| Reaction time trials completed | 0.7 | 1.0 | 1.1 | -0.9 | 1.0 | -1.0 | 1.1 | 0.9 | -1.0 | 1.0 | -1.0 | -1.1 | 1.0 | -0.9 |
| Intermittent access total locomotion | 0.7 | 0.7 | 0.9 | 0.8 | -0.8 | 1.0 | -0.9 | -0.9 | 0.9 | -0.9 | 0.8 | 0.9 | -0.9 | 0.8 |
| Locomotion velocity, session 1 | 0.7 | 0.8 | 1.1 | -0.5 | 0.8 | -1.1 | 0.9 | 0.9 | -1.0 | 1.0 | -0.9 | -1.1 | 1.0 | -0.5 |
| Condit. Reinf. active-inactive response ratio | 0.7 | 0.8 | 1.1 | 0.9 | -0.7 | 1.1 | -0.9 | -0.8 | 0.9 | -0.9 | 0.8 | 1.1 | -0.9 | 0.9 |
| Condit. Reinf. active responses | 0.7 | 0.9 | 1.1 | 1.1 | -1.0 | 0.8 | -0.9 | -1.0 | 0.9 | -0.9 | 1.0 | 0.9 | -0.9 | 1.1 |
| Total zone transitions, hab. session 2 | 0.7 | 0.9 | 0.9 | -1.0 | 0.9 | -0.9 | 0.9 | 0.9 | -0.9 | 0.9 | -0.9 | -0.9 | 0.9 | -1.0 |
| Bone: cortical porosity | 0.7 | 0.8 | 1.3 | 0.3 | -0.8 | 1.1 | -1.0 | -1.0 | 1.0 | -1.0 | 0.9 | 1.0 | -1.0 | 0.3 |
| Area under the delay curve | 0.7 | 0.8 | 1.1 | 0.5 | -0.8 | 1.0 | -1.0 | -1.0 | 1.0 | -0.9 | 0.9 | 0.9 | -1.0 | 0.5 |
| Delay disc. indifference point, 4s delay | 0.7 | 0.7 | 1.1 | 0.8 | -1.0 | 0.5 | -0.8 | -1.1 | 0.8 | -0.8 | 0.9 | 0.5 | -0.8 | 0.8 |
| Time >=10cm from walls, locomotor time 1 | 0.7 | 0.7 | 0.9 | 0.6 | -0.8 | 0.9 | -0.9 | -0.9 | 0.9 | -0.9 | 0.9 | 0.8 | -0.9 | 0.6 |
| Bouts of movement, locomotor time 1 | 0.7 | 0.7 | 1.1 | -1.0 | 1.0 | -0.7 | 0.7 | 1.0 | -0.7 | 0.7 | -0.9 | -0.9 | 0.7 | -1.0 |
| Run reversals in cocaine runway, males | 0.7 | 0.7 | 1.1 | 1.1 | -0.9 | 0.8 | -0.8 | -1.0 | 0.7 | -0.7 | 0.8 | 0.7 | -0.8 | 1.1 |
| Cu content in liver | 0.7 | 0.8 | 1.2 | 0.1 | 0.8 | -1.1 | 0.9 | 1.0 | -1.0 | 1.0 | -0.9 | -1.1 | 1.0 | 0.1 |
| Locomotor activity | 0.6 | 0.9 | 1.2 | 0.6 | -1.0 | 1.0 | -1.0 | -1.1 | 1.0 | -1.0 | 1.0 | 0.9 | -1.0 | 0.6 |
| Reaction time trials AUC | 0.6 | 0.8 | 0.9 | -0.9 | 0.9 | -0.8 | 0.9 | 0.7 | -0.9 | 0.9 | -0.9 | -0.9 | 0.9 | -0.9 |
| Condit. Reinf. active minus inactive responses | 0.6 | 0.7 | 1.1 | 1.1 | -0.8 | 0.8 | -0.8 | -0.7 | 0.8 | -0.8 | 0.8 | 0.9 | -0.8 | 1.1 |
| Intermittent access day 15 total locomotion | 0.6 | 0.6 | 0.8 | 0.6 | -0.7 | 0.9 | -0.8 | -0.8 | 0.8 | -0.8 | 0.7 | 0.8 | -0.8 | 0.6 |
| Context. condit. distance diff. score | 0.6 | 0.8 | 1.8 | -1.4 | 0.9 | -0.6 | 0.8 | 0.7 | -0.7 | 0.7 | -0.8 | -0.6 | 0.7 | -1.4 |
| Locomotion velocity, session 2 | 0.6 | 0.7 | 1.0 | -0.3 | 0.7 | -1.0 | 0.9 | 0.9 | -0.9 | 0.9 | -0.8 | -1.0 | 0.9 | -0.3 |
| Time in familiar zone, hab. session 1 | 0.6 | 0.6 | 0.7 | 0.8 | -0.6 | 0.9 | -0.8 | -0.6 | 0.7 | -0.7 | 0.7 | 0.9 | -0.7 | 0.8 |
| Time in novel zone, hab. session 1 | 0.6 | 0.6 | 0.8 | 0.6 | -0.9 | 0.7 | -0.8 | -0.9 | 0.8 | -0.8 | 0.9 | 0.8 | -0.8 | 0.6 |
| Locomotion velocity, hab. session 1 | 0.6 | 0.8 | 1.0 | -0.7 | 1.0 | -0.9 | 0.9 | 1.0 | -1.0 | 1.0 | -1.0 | -0.9 | 1.0 | -0.7 |
| Bone: cortical porosity | 0.6 | 0.6 | 0.9 | 0.4 | -0.7 | 1.0 | -0.9 | -0.9 | 0.9 | -0.9 | 0.8 | 0.9 | -0.9 | 0.4 |
| Bone: periosteal perimeter | 0.6 | 1.1 | 1.2 | -0.9 | 1.1 | -1.0 | 1.1 | 1.1 | -1.1 | 1.1 | -1.1 | -0.9 | 1.0 | -0.9 |
| Active lever presses in extinction session 6 | 0.6 | 0.6 | 1.9 | 1.4 | -0.6 | 0.7 | -0.6 | -0.5 | 0.5 | -0.5 | 0.6 | 0.6 | -0.5 | 1.4 |
| Delta ambulatory time before/after self-admin | 0.6 | 0.6 | 1.9 | -1.4 | 0.7 | -0.3 | 0.6 | 0.7 | -0.6 | 0.6 | -0.6 | -0.3 | 0.6 | -1.4 |
| Time in closed arm after self-admin | 0.6 | 0.6 | 1.1 | -0.7 | 0.8 | -0.8 | 0.8 | 1.0 | -0.8 | 0.8 | -0.8 | -0.7 | 0.8 | -0.7 |
| Delay discount hyperbolic model param | 0.6 | 0.6 | 0.9 | -0.5 | 0.8 | -0.9 | 0.9 | 1.0 | -0.8 | 0.8 | -0.8 | -0.8 | 0.9 | -0.5 |
| Glucose | 0.5 | 0.8 | 1.1 | 0.5 | -1.0 | 0.9 | -1.0 | -1.1 | 1.0 | -1.0 | 1.0 | 0.8 | -1.0 | 0.5 |
| Number of licking bursts | 0.5 | 0.6 | 1.0 | 0.3 | -0.9 | 0.7 | -0.8 | -0.9 | 0.8 | -0.8 | 0.8 | 1.0 | -0.8 | 0.3 |
| Delay discounting total patch changes 18 sec | 0.5 | 0.6 | 1.1 | 0.8 | -1.0 | 0.4 | -0.8 | -0.7 | 0.8 | -0.8 | 0.9 | 0.4 | -0.8 | 0.8 |
| Delay discounting water rate 18 sec | 0.5 | 0.6 | 1.0 | 0.6 | -0.7 | 1.0 | -0.8 | -0.9 | 0.8 | -0.8 | 0.8 | 0.8 | -0.8 | 0.6 |
| Reaction time num false alarms AUC | 0.5 | 0.8 | 1.0 | 0.7 | -0.8 | 0.9 | -0.9 | -0.9 | 0.9 | -0.9 | 0.9 | 1.0 | -0.9 | 0.7 |
| Pavlov. Cond. change in total contacts | 0.5 | 0.7 | 1.0 | 1.0 | -0.9 | 0.7 | -0.8 | -0.8 | 0.8 | -0.8 | 0.8 | 0.6 | -0.8 | 1.0 |
| Short access day 10 total inactive lever presses | 0.5 | 0.6 | 0.8 | -0.2 | 0.9 | -0.8 | 0.8 | 0.9 | -0.8 | 0.8 | -0.8 | -0.8 | 0.9 | -0.2 |
| Short access total locomotion | 0.5 | 0.5 | 1.0 | 0.9 | -0.4 | 1.0 | -0.7 | -0.5 | 0.7 | -0.7 | 0.6 | 0.9 | -0.6 | 0.9 |
| Locomotion distance, session 3 | 0.5 | 0.5 | 0.8 | -0.3 | 0.7 | -0.9 | 0.8 | 0.8 | -0.8 | 0.8 | -0.7 | -0.9 | 0.8 | -0.3 |
| Degree of sensitization distance | 0.5 | 0.5 | 1.4 | -1.2 | 0.8 | -0.3 | 0.5 | 0.6 | -0.5 | 0.5 | -0.6 | -0.3 | 0.5 | -1.2 |
| Condit. Reinf. active minus inactive responses | 0.5 | 0.6 | 1.1 | 1.0 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 1.0 |
| Condit. Reinf. inactive responses | 0.5 | 0.6 | 0.8 | 0.4 | -0.8 | 0.7 | -0.8 | -0.9 | 0.8 | -0.8 | 0.8 | 0.7 | -0.8 | 0.4 |
| Time in familiar zone, hab. session 2 | 0.5 | 0.6 | 0.8 | 0.9 | -0.6 | 0.8 | -0.7 | -0.6 | 0.7 | -0.7 | 0.6 | 0.8 | -0.7 | 0.9 |
| Bone: tissue strength | 0.5 | 0.5 | 1.2 | -1.1 | 0.6 | -0.7 | 0.7 | 0.4 | -0.6 | 0.6 | -0.6 | -0.7 | 0.6 | -1.1 |
| Time in open arm after self-admin | 0.5 | 0.6 | 0.8 | -0.7 | 0.9 | -0.6 | 0.8 | 0.6 | -0.8 | 0.8 | -0.9 | -0.7 | 0.8 | -0.7 |
| Sum of active levers in priming session hrs 5-6 | 0.5 | 0.5 | 0.7 | 0.8 | -0.5 | 0.8 | -0.7 | -0.5 | 0.7 | -0.6 | 0.6 | 0.6 | -0.6 | 0.8 |
| Total heroin consumption | 0.5 | 0.6 | 1.6 | 1.3 | -0.9 | 0.5 | -0.7 | -0.7 | 0.6 | -0.6 | 0.7 | 0.3 | -0.6 | 1.3 |
| Delay disc. indifference point, 8s delay | 0.5 | 0.5 | 1.1 | 0.1 | -0.5 | 1.0 | -0.8 | -0.9 | 0.8 | -0.8 | 0.7 | 0.7 | -0.8 | 0.1 |
| K content in liver | 0.5 | 0.5 | 1.2 | 1.1 | -0.9 | 0.3 | -0.6 | -0.7 | 0.6 | -0.6 | 0.8 | 0.3 | -0.6 | 1.1 |
| Mg content in liver | 0.5 | 0.5 | 0.8 | 0.9 | -0.9 | 0.3 | -0.6 | -0.8 | 0.6 | -0.6 | 0.7 | 0.3 | -0.6 | 0.9 |
| Right kidney weight | 0.4 | 1.2 | 1.8 | -0.6 | 1.0 | -1.3 | 1.2 | 1.1 | -1.2 | 1.2 | -1.1 | -1.3 | 1.2 | -0.6 |
| Soleus weight | 0.4 | 1.1 | 1.8 | -0.2 | -1.1 | 1.1 | -1.1 | -1.3 | 1.2 | -1.2 | 1.2 | 1.1 | -1.2 | -0.2 |
| Delay discounting water rate 24 sec | 0.4 | 0.5 | 1.0 | 1.0 | -0.5 | 0.9 | -0.7 | -0.6 | 0.6 | -0.6 | 0.6 | 0.7 | -0.6 | 1.0 |
| Median of all reaction times | 0.4 | 0.5 | 0.8 | 0.9 | -0.9 | 0.4 | -0.6 | -0.8 | 0.6 | -0.6 | 0.7 | 0.5 | -0.6 | 0.9 |
| Condit. Reinf. active-inactive response ratio | 0.4 | 0.4 | 0.9 | 1.0 | -0.7 | 0.4 | -0.5 | -0.5 | 0.5 | -0.5 | 0.6 | 0.5 | -0.5 | 1.0 |
| Intermittent access standard deviation | 0.4 | 0.5 | 1.5 | 1.2 | -0.4 | 0.6 | -0.5 | -0.3 | 0.4 | -0.4 | 0.4 | 0.5 | -0.4 | 1.2 |
| Stereotopy head waving duration, day 3 | 0.4 | 0.5 | 0.9 | 0.2 | -0.6 | 0.9 | -0.8 | -0.7 | 0.8 | -0.8 | 0.7 | 1.0 | -0.8 | 0.2 |
| Bone: minimum diameter | 0.4 | 0.8 | 1.0 | -0.9 | 1.0 | -0.8 | 0.9 | 1.0 | -0.9 | 0.9 | -1.0 | -0.7 | 0.9 | -0.9 |
| Diff in mean of infusions in LGA sessions | 0.4 | 0.4 | 1.2 | -0.6 | 1.1 | 0.1 | 0.5 | 0.9 | -0.5 | 0.6 | -0.8 | -0.1 | 0.6 | -0.6 |
| Ambulatory time before self-admin | 0.4 | 0.4 | 0.6 | -0.2 | 0.8 | -0.5 | 0.7 | 0.8 | -0.7 | 0.7 | -0.8 | -0.7 | 0.7 | -0.2 |
| Delay discount exponential model param | 0.4 | 0.4 | 0.7 | -0.4 | 0.6 | -0.7 | 0.7 | 0.8 | -0.7 | 0.7 | -0.6 | -0.6 | 0.7 | -0.4 |
| Latency to leave start box in cocaine runway, M | 0.4 | 0.4 | 0.9 | 0.9 | 0.1 | -0.7 | 0.4 | 0.3 | -0.5 | 0.5 | -0.3 | -0.7 | 0.5 | 0.9 |
| Epididymis fat weight | 0.3 | 0.6 | 1.3 | -0.4 | 1.1 | -0.5 | 0.8 | 1.1 | -0.8 | 0.8 | -1.0 | -0.5 | 0.9 | -0.4 |
| Delay discounting water rate 12 sec | 0.3 | 0.5 | 0.7 | -0.7 | 0.6 | -0.7 | 0.7 | 0.5 | -0.7 | 0.7 | -0.6 | -0.8 | 0.6 | -0.7 |
| Reaction time premature initiation rate | 0.3 | 0.3 | 0.9 | 0.2 | -0.4 | 0.9 | -0.6 | -0.4 | 0.7 | -0.6 | 0.6 | 0.8 | -0.6 | 0.2 |
| Saline control response | 0.3 | 0.4 | 0.8 | -0.5 | -0.3 | 0.8 | -0.6 | -0.6 | 0.6 | -0.6 | 0.5 | 0.9 | -0.7 | -0.5 |
| Intermittent access terminal intake (last 3 days) | 0.3 | 0.4 | 0.5 | 0.7 | -0.4 | 0.7 | -0.6 | -0.4 | 0.6 | -0.6 | 0.5 | 0.7 | -0.5 | 0.7 |
| Intermittent access day 1 locomotion | 0.3 | 0.3 | 0.5 | 0.6 | -0.5 | 0.7 | -0.6 | -0.6 | 0.6 | -0.6 | 0.5 | 0.6 | -0.6 | 0.6 |
| Short access day 1 total infusions | 0.3 | 0.3 | 1.1 | 1.0 | -0.2 | 0.6 | -0.4 | -0.2 | 0.4 | -0.4 | 0.3 | 0.6 | -0.3 | 1.0 |
| Locomotion velocity, hab. session 2 | 0.3 | 0.4 | 0.6 | -0.6 | 0.7 | -0.4 | 0.6 | 0.7 | -0.6 | 0.6 | -0.7 | -0.4 | 0.6 | -0.6 |
| Total zone transitions, NPP test | 0.3 | 0.5 | 0.5 | -0.7 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 |
| Locomotion velocity, NPP test | 0.3 | 0.4 | 0.4 | -0.5 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.6 | -0.6 | -0.7 | 0.6 | -0.5 |
| Time to tail flick, test, after self-admin | 0.3 | 0.3 | 1.0 | 1.0 | -0.6 | -0.1 | -0.3 | -0.3 | 0.3 | -0.3 | 0.4 | -0.3 | -0.3 | 1.0 |
| Delta time to tail flick, vehicle, before/after SA | 0.3 | 0.3 | 0.4 | 0.1 | -0.6 | 0.6 | -0.6 | -0.5 | 0.6 | -0.6 | 0.6 | 0.5 | -0.6 | 0.1 |
| Distance moved, locomotor task time 1 | 0.3 | 0.3 | 0.6 | 0.8 | -0.5 | 0.7 | -0.5 | -0.5 | 0.5 | -0.5 | 0.5 | 0.6 | -0.5 | 0.8 |
| Std. dev. time between licks in bursts | 0.2 | 0.2 | 0.4 | -0.1 | 0.4 | -0.6 | 0.5 | 0.4 | -0.6 | 0.5 | -0.5 | -0.6 | 0.6 | -0.1 |
| Reaction time mean minus median AUC | 0.2 | 0.3 | 0.6 | 0.0 | -0.4 | 0.6 | -0.5 | -0.5 | 0.6 | -0.5 | 0.5 | 0.8 | -0.6 | 0.0 |
| Pavlov. Cond. lever latency | 0.2 | 0.3 | 0.4 | -0.6 | 0.6 | -0.4 | 0.5 | 0.6 | -0.5 | 0.5 | -0.6 | -0.5 | 0.5 | -0.6 |
| Pavlov. Cond. index score | 0.2 | 0.2 | 0.4 | 0.6 | -0.6 | 0.3 | -0.5 | -0.6 | 0.5 | -0.5 | 0.5 | 0.4 | -0.5 | 0.6 |
| Intermittent access intake day 1-15 change | 0.2 | 0.2 | 0.3 | 0.5 | -0.2 | 0.5 | -0.4 | -0.2 | 0.4 | -0.3 | 0.3 | 0.6 | -0.3 | 0.5 |
| Intermittent access day 15 total infusions | 0.2 | 0.3 | 0.4 | 0.7 | -0.3 | 0.6 | -0.5 | -0.4 | 0.5 | -0.5 | 0.4 | 0.6 | -0.5 | 0.7 |
| Short access day 10 total infusions | 0.2 | 0.2 | 0.4 | 0.6 | -0.4 | 0.5 | -0.5 | -0.4 | 0.5 | -0.5 | 0.4 | 0.4 | -0.4 | 0.6 |
| One hour access (shock baseline) | 0.2 | 0.2 | 0.4 | 0.5 | -0.2 | 0.7 | -0.4 | -0.3 | 0.4 | -0.4 | 0.3 | 0.6 | -0.4 | 0.5 |
| Number of responses in last shaping day | 0.2 | 0.2 | 1.2 | 1.1 | -0.2 | -0.3 | 0.1 | 0.0 | -0.1 | 0.1 | 0.0 | -0.3 | 0.2 | 1.1 |
| Stereotopy head waving duration, day 7 | 0.2 | 0.3 | 0.5 | 0.5 | -0.7 | 0.4 | -0.5 | -0.7 | 0.5 | -0.6 | 0.6 | 0.4 | -0.5 | 0.5 |
| Time in novel zone, NPP test | 0.2 | 0.2 | 0.4 | -0.6 | 0.4 | -0.5 | 0.5 | 0.4 | -0.4 | 0.4 | -0.4 | -0.5 | 0.4 | -0.6 |
| Bone: cortical area | 0.2 | 0.3 | 0.5 | 0.2 | -0.6 | 0.4 | -0.5 | -0.7 | 0.6 | -0.6 | 0.6 | 0.5 | -0.6 | 0.2 |
| Bone: periosteal estimation | 0.2 | 0.4 | 0.5 | -0.7 | 0.7 | -0.5 | 0.6 | 0.7 | -0.6 | 0.6 | -0.6 | -0.5 | 0.6 | -0.7 |
| Distance traveled before self-admin | 0.2 | 0.2 | 0.5 | 0.0 | 0.7 | -0.1 | 0.4 | 0.6 | -0.5 | 0.5 | -0.6 | -0.2 | 0.5 | 0.0 |
| Time to tail flick, vehicle, before self-admin | 0.2 | 0.2 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | -0.5 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 |
| Fecal boli incidents, locomotor time 1 | 0.2 | 0.2 | 0.4 | -0.4 | 0.3 | -0.6 | 0.5 | 0.3 | -0.5 | 0.5 | -0.4 | -0.6 | 0.5 | -0.4 |
| Change in fecal boli incidents, locomotor task | 0.2 | 0.1 | 0.4 | -0.3 | -0.1 | 0.6 | -0.4 | -0.3 | 0.4 | -0.4 | 0.2 | 0.5 | -0.4 | -0.3 |
| Weight adjusted by age | 0.2 | 0.2 | 0.3 | -0.5 | 0.4 | -0.6 | 0.4 | 0.4 | -0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.5 |
| Food seeking constrained by brief footshock | 0.2 | 0.2 | 0.3 | 0.1 | -0.5 | 0.3 | -0.5 | -0.4 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.1 |
| Seeking ratio, punishment vs. effort | 0.2 | 0.2 | 0.3 | -0.5 | -0.4 | 0.2 | -0.4 | -0.5 | 0.5 | -0.5 | 0.4 | 0.4 | -0.5 | -0.5 |
| Na content in liver | 0.2 | 0.2 | 0.4 | 0.4 | -0.6 | 0.3 | -0.5 | -0.5 | 0.5 | -0.5 | 0.6 | 0.3 | -0.5 | 0.4 |
| BMI without tail | 0.1 | 0.1 | 0.3 | -0.2 | 0.2 | -0.5 | 0.4 | 0.3 | -0.4 | 0.4 | -0.3 | -0.5 | 0.4 | -0.2 |
| Liver weight, left | 0.1 | 0.1 | 0.2 | 0.1 | 0.3 | -0.3 | 0.3 | 0.4 | -0.3 | 0.4 | -0.3 | -0.5 | 0.4 | 0.1 |
| Liver weight, right | 0.1 | 0.2 | 0.9 | 1.0 | -0.2 | 0.2 | -0.3 | -0.1 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 1.0 |
| Retroperitoneal fat weight | 0.1 | 0.2 | 0.5 | 0.0 | 0.7 | -0.3 | 0.5 | 0.7 | -0.5 | 0.5 | -0.6 | -0.3 | 0.6 | 0.0 |
| Mean num. licks in bursts | 0.1 | 0.1 | 0.3 | 0.6 | -0.1 | 0.1 | -0.1 | -0.0 | 0.1 | -0.1 | 0.1 | -0.1 | -0.0 | 0.6 |
| Delay discounting time to switch 0 sec | 0.1 | 0.1 | 0.2 | 0.4 | -0.2 | 0.2 | -0.3 | -0.2 | 0.2 | -0.2 | 0.2 | 0.4 | -0.2 | 0.4 |
| Reaction time mean minus median | 0.1 | 0.1 | 0.3 | -0.5 | 0.3 | -0.2 | 0.3 | 0.3 | -0.3 | 0.3 | -0.3 | -0.0 | 0.3 | -0.5 |
| Reaction time premature initiations | 0.1 | 0.1 | 0.4 | -0.6 | 0.4 | 0.1 | 0.2 | 0.4 | -0.2 | 0.2 | -0.3 | -0.1 | 0.2 | -0.6 |
| Social responses | 0.1 | 0.1 | 0.2 | 0.4 | -0.3 | 0.3 | -0.3 | -0.2 | 0.3 | -0.3 | 0.3 | 0.2 | -0.3 | 0.4 |
| Conditioned locomotion | 0.1 | 0.1 | 0.2 | 0.4 | -0.2 | 0.5 | -0.4 | -0.4 | 0.4 | -0.4 | 0.3 | 0.4 | -0.3 | 0.4 |
| Pavlov. Cond. latency score | 0.1 | 0.1 | 0.2 | 0.4 | -0.5 | 0.2 | -0.3 | -0.5 | 0.3 | -0.3 | 0.4 | 0.3 | -0.4 | 0.4 |
| Pavlov. Cond. magazine entry number | 0.1 | 0.1 | 0.2 | -0.3 | 0.4 | -0.2 | 0.3 | 0.5 | -0.3 | 0.3 | -0.4 | -0.2 | 0.3 | -0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 0.2 | 0.4 | -0.4 | 0.1 | -0.3 | -0.4 | 0.3 | -0.3 | 0.3 | 0.2 | -0.3 | 0.4 |
| Intermittent access intake escalation | 0.1 | 0.1 | 0.3 | 0.5 | -0.1 | 0.3 | -0.2 | -0.1 | 0.2 | -0.2 | 0.2 | 0.4 | -0.2 | 0.5 |
| Intermittent access intake escalation 2 | 0.1 | 0.1 | 0.1 | -0.0 | 0.2 | -0.2 | 0.3 | 0.3 | -0.3 | 0.3 | -0.3 | -0.2 | 0.3 | -0.0 |
| Intermittent access day 1 total infusions | 0.1 | 0.1 | 0.2 | 0.3 | -0.2 | 0.4 | -0.4 | -0.3 | 0.4 | -0.4 | 0.3 | 0.3 | -0.4 | 0.3 |
| Post-drug Anxiety | 0.1 | 0.1 | 0.2 | -0.4 | 0.2 | -0.1 | 0.2 | 0.2 | -0.2 | 0.2 | -0.2 | -0.1 | 0.1 | -0.4 |
| Progressive ratio test 2 inactive lever presses | 0.1 | 0.2 | 0.6 | 0.8 | -0.3 | 0.0 | -0.2 | -0.3 | 0.2 | -0.2 | 0.2 | -0.1 | -0.2 | 0.8 |
| Compulsive drug intake | 0.1 | 0.1 | 0.4 | -0.6 | 0.4 | -0.3 | 0.3 | 0.4 | -0.2 | 0.2 | -0.3 | -0.1 | 0.2 | -0.6 |
| Locomotion velocity, session 3 | 0.1 | 0.2 | 0.3 | 0.2 | 0.4 | -0.3 | 0.4 | 0.5 | -0.4 | 0.4 | -0.4 | -0.3 | 0.5 | 0.2 |
| Locomotion distance, session 7 | 0.1 | 0.2 | 0.3 | -0.6 | 0.6 | -0.2 | 0.4 | 0.5 | -0.3 | 0.4 | -0.5 | -0.2 | 0.4 | -0.6 |
| Time in novel zone, hab. session 2 | 0.1 | 0.1 | 0.1 | 0.3 | -0.3 | 0.2 | -0.2 | -0.3 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.3 |
| Total locomotion distance, hab. session 2 | 0.1 | 0.1 | 0.2 | -0.3 | 0.5 | -0.2 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | -0.2 | 0.4 | -0.3 |
| Bone volume | 0.1 | 0.2 | 0.4 | 0.6 | -0.6 | 0.2 | -0.4 | -0.5 | 0.4 | -0.4 | 0.5 | 0.2 | -0.4 | 0.6 |
| Bone: trabecular thickness | 0.1 | 0.1 | 0.2 | 0.4 | -0.4 | -0.0 | -0.2 | -0.3 | 0.2 | -0.2 | 0.3 | -0.0 | -0.2 | 0.4 |
| Delta time in open arm before/after self-admin | 0.1 | 0.0 | 0.2 | 0.0 | -0.2 | 0.1 | -0.2 | -0.5 | 0.2 | -0.2 | 0.2 | 0.1 | -0.2 | 0.0 |
| Time to tail flick, vehicle, after self-admin | 0.1 | 0.1 | 0.3 | 0.3 | -0.5 | 0.2 | -0.3 | -0.3 | 0.3 | -0.3 | 0.4 | 0.3 | -0.3 | 0.3 |
| Delay disc. indifference point, 24s delay | 0.1 | 0.1 | 0.2 | -0.1 | -0.3 | 0.3 | -0.3 | -0.4 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | -0.1 |
| Bouts of movement, locomotor time 2 | 0.1 | 0.1 | 0.2 | 0.5 | -0.1 | 0.1 | -0.3 | -0.0 | 0.2 | -0.2 | 0.1 | 0.1 | -0.2 | 0.5 |
| Distance moved, locomotor task time 2 | 0.1 | 0.1 | 0.2 | 0.5 | -0.3 | 0.1 | -0.1 | -0.2 | 0.1 | -0.1 | 0.2 | 0.1 | -0.1 | 0.5 |
| Seeking ratio, delayed vs. immediate footshock | 0.1 | 0.1 | 0.5 | 0.7 | -0.1 | 0.1 | -0.1 | 0.1 | 0.0 | -0.0 | 0.1 | 0.1 | -0.0 | 0.7 |
| Progressive ratio | 0.1 | 0.1 | 0.5 | 0.7 | -0.1 | 0.1 | -0.1 | -0.0 | 0.0 | -0.0 | 0.1 | 0.1 | -0.0 | 0.7 |
| Cd content in liver | 0.1 | 0.1 | 0.3 | 0.4 | -0.2 | 0.5 | -0.3 | -0.2 | 0.3 | -0.3 | 0.3 | 0.5 | -0.3 | 0.4 |
| Sr content in liver | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | -0.4 | 0.3 | 0.4 | -0.4 | 0.4 | -0.3 | -0.4 | 0.4 | 0.2 |
| Water consumed over 24 hours | 0.0 | 0.0 | 0.2 | -0.4 | -0.0 | -0.1 | 0.1 | -0.1 | -0.0 | 0.0 | -0.0 | 0.0 | 0.0 | -0.4 |
| Indifference point AUC | 0.0 | 0.0 | 0.2 | -0.0 | -0.1 | -0.4 | 0.2 | 0.2 | -0.1 | 0.1 | -0.0 | -0.4 | 0.1 | -0.0 |
| Indifference point function ln k | 0.0 | 0.0 | 0.1 | -0.3 | -0.1 | 0.2 | -0.1 | -0.2 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.3 |
| Indifference point function log k | 0.0 | 0.0 | 0.1 | -0.3 | -0.1 | 0.2 | -0.1 | -0.2 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.3 |
| Delay discounting water rate 0 sec | 0.0 | 0.0 | 0.1 | 0.3 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.2 | 0.2 | 0.3 |
| Reaction time mean | 0.0 | 0.0 | 0.1 | 0.3 | -0.3 | -0.1 | -0.1 | -0.2 | 0.1 | -0.1 | 0.2 | 0.1 | -0.1 | 0.3 |
| Reaction time mean AUC | 0.0 | 0.0 | 0.1 | 0.3 | -0.2 | -0.1 | -0.0 | -0.1 | 0.0 | -0.0 | 0.1 | 0.0 | -0.0 | 0.3 |
| Std. dev. reaction times | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.3 | -0.1 | -0.1 |
| Social response proportion | 0.0 | 0.1 | 0.3 | -0.5 | 0.1 | 0.1 | -0.0 | -0.0 | 0.0 | -0.0 | -0.0 | 0.1 | -0.1 | -0.5 |
| Social time | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 |
| Condit. Reinf. lever presses | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | 0.2 | -0.2 | -0.1 | 0.2 | -0.2 | 0.2 | 0.4 | -0.2 | 0.2 |
| Pavlov. Cond. magazine entry latency | 0.0 | 0.0 | 0.1 | -0.2 | 0.0 | -0.3 | 0.2 | -0.0 | -0.2 | 0.1 | -0.1 | -0.2 | 0.1 | -0.2 |
| Intermittent access total infusions | 0.0 | 0.0 | 0.1 | 0.3 | 0.1 | 0.3 | -0.2 | 0.0 | 0.1 | -0.1 | 0.0 | 0.2 | -0.1 | 0.3 |
| Lifetime Intake | 0.0 | 0.0 | 0.1 | 0.3 | 0.1 | 0.3 | -0.1 | 0.1 | 0.1 | -0.1 | -0.0 | 0.2 | -0.0 | 0.3 |
| Short access total infusions | 0.0 | 0.0 | 0.2 | 0.5 | 0.1 | 0.2 | -0.1 | 0.1 | 0.0 | -0.0 | -0.0 | 0.1 | 0.0 | 0.5 |
| One hour access (0.3 mA shock) | 0.0 | 0.0 | 0.1 | -0.2 | 0.2 | 0.2 | -0.1 | 0.0 | 0.2 | -0.1 | -0.0 | 0.3 | -0.1 | -0.2 |
| Total locomotion distance, hab. session 1 | 0.0 | 0.0 | 0.1 | 0.0 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | 0.0 |
| Total locomotion distance, NPP test | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.0 | -0.1 | -0.0 | 0.1 | -0.1 | 0.1 | -0.0 | -0.0 | 0.1 |
| Bone surface | 0.0 | 0.0 | 0.1 | 0.3 | -0.2 | -0.2 | 0.1 | -0.0 | -0.1 | 0.1 | 0.0 | -0.2 | 0.1 | 0.3 |
| Bone: elastic displacement | 0.0 | 0.0 | 0.0 | -0.1 | -0.2 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.0 | -0.1 | -0.1 |
| Bone: elastic work | 0.0 | 0.0 | 0.1 | 0.3 | -0.1 | -0.1 | -0.0 | -0.0 | 0.0 | -0.0 | 0.1 | -0.2 | 0.0 | 0.3 |
| Bone: maximum diameter | 0.0 | 0.0 | 0.0 | 0.2 | -0.2 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.2 | -0.1 | 0.2 |
| Bone: maximum force | 0.0 | 0.1 | 0.1 | -0.1 | -0.2 | 0.3 | -0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | -0.1 |
| Bone: maximum moment | 0.0 | 0.0 | 0.1 | -0.3 | -0.1 | 0.2 | -0.1 | -0.2 | 0.2 | -0.2 | 0.1 | 0.2 | -0.2 | -0.3 |
| Bone: stiffness | 0.0 | 0.1 | 0.1 | -0.0 | -0.2 | 0.3 | -0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 0.4 | -0.3 | -0.0 |
| Bone: trabecular tissue density | 0.0 | 0.0 | 0.0 | -0.2 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.2 |
| Rest time, locomotor task time 1 | 0.0 | 0.0 | 0.1 | -0.2 | 0.0 | -0.0 | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | -0.0 | 0.0 | -0.2 |
| Vertical activity count, locomotor time 1 | 0.0 | 0.0 | 0.0 | -0.0 | 0.2 | 0.2 | 0.1 | 0.1 | -0.1 | 0.1 | -0.2 | -0.0 | 0.1 | -0.0 |
| Total resting periods, locomotor time 2 | 0.0 | 0.0 | 0.1 | 0.3 | 0.2 | -0.1 | -0.0 | 0.2 | -0.0 | 0.0 | -0.1 | -0.1 | 0.0 | 0.3 |
| Vertical activity count, locomotor time 2 | 0.0 | 0.0 | 0.0 | -0.2 | 0.2 | 0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.