Hub : Genes

Coq10a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000029571	0.03	0.03	1.7e-03	0.02	0.01	0.01	0.01	3.6e-03	1.8e-02	5.1e-02	1.3e-02
2	Liver	mRNA stability	ENSRNOG00000029571	0.07	0.05	1.4e-07	0.06	0.06	0.06	0.06	1.8e-07	7.2e-07	3.8e-07	4.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	7.4	24.0	24.3	-4.9	4.9
BMI without tail	1.8	3.7	3.8	-1.9	2.0
Body weight	1.1	4.6	5.2	-2.3	2.0
Epididymis fat weight	0.0	0.1	0.1	0.3	-0.2
Glucose	1.8	2.8	2.8	-1.6	1.7
Heart weight	0.1	0.2	0.2	-0.5	0.3
Left kidney weight	0.0	0.1	0.1	0.2	-0.4
Right kidney weight	0.4	1.1	1.4	0.9	-1.2
Tail length	4.0	12.1	12.4	3.4	-3.5
Length with tail	1.9	7.0	7.6	2.5	-2.8
Length without tail	0.0	0.0	0.0	-0.0	-0.2
Liver weight, left	2.2	3.6	3.6	-1.9	1.9
Liver weight, right	0.9	1.5	1.5	-1.2	1.2
Parametrial fat weight	0.0	0.0	0.0	0.1	0.2
Retroperitoneal fat weight	2.5	8.4	9.3	-3.1	2.7
Intraocular pressure	0.0	0.1	0.1	0.1	-0.3
Extensor digitorum longus weight	6.3	25.1	26.5	-5.1	4.9
Soleus weight	6.0	17.4	18.4	-4.3	4.0
Tibialis anterior weight	1.0	3.4	4.4	-2.1	1.5
Tibia length	0.9	2.7	3.1	1.5	-1.8
Number of licking bursts	4.7	5.6	6.0	-2.3	2.4
Food consumed during 24 hour testing period	0.5	0.5	0.6	-0.7	0.8
Times rat made contact with spout	1.4	1.6	1.7	-1.3	1.2
Mean time between licks in bursts	0.3	0.4	0.5	0.7	-0.6
Mean num. licks in bursts	1.2	1.5	1.8	1.1	-1.3
Std. dev. time between licks in bursts	0.8	0.9	1.0	1.0	-0.9
Water consumed over 24 hours	0.3	0.4	0.5	-0.5	0.7
Indifference point 0 sec	3.0	4.9	5.1	-2.3	2.2
Indifference point AUC	0.5	0.6	0.7	0.8	-0.7
Indifference point function ln k	0.2	0.3	0.3	-0.6	0.4
Indifference point function log k	0.2	0.3	0.3	-0.6	0.4
Delay discounting total patch changes 0 sec	3.0	4.9	5.1	-2.3	2.2
Delay discounting total patch changes 12 sec	2.5	3.3	3.5	-1.7	1.9
Delay discounting total patch changes 18 sec	0.0	0.0	0.0	-0.1	0.2
Delay discounting total patch changes 24 sec	0.3	0.3	0.3	-0.6	0.6
Delay discounting total patch changes 6 sec	1.9	2.8	3.0	-1.6	1.7
Delay discounting time to switch 0 sec	0.0	0.0	0.0	-0.2	0.2
Delay discounting water rate 0 sec	1.0	1.5	1.6	-1.3	1.2
Delay discounting water rate 12 sec	1.3	2.0	2.2	-1.5	1.4
Delay discounting water rate 18 sec	0.5	0.6	0.7	-0.9	0.7
Delay discounting water rate 24 sec	3.3	4.5	4.6	-2.1	2.1
Delay discounting water rate 6 sec	0.0	0.0	0.0	-0.0	-0.2
Locomotor activity	4.8	7.6	8.5	2.6	-2.9
Locomotor testing distance	1.8	3.0	3.4	1.6	-1.9
Locomotor testing rearing	0.0	0.0	0.0	-0.1	0.0
Light reinforcement 1	4.0	7.3	7.8	2.6	-2.8
Light reinforcement 2	0.9	1.1	1.4	1.2	-1.0
Reaction time number correct	1.5	2.1	2.3	-1.5	1.4
Reaction time mean minus median	2.1	2.8	3.4	1.5	-1.8
Reaction time mean minus median AUC	3.6	4.6	5.4	2.0	-2.3
Reaction time num false alarms	0.8	1.1	1.1	-1.0	1.1
Reaction time num false alarms AUC	1.1	1.5	1.5	-1.2	1.2
Reaction time trials correct on left	1.5	2.1	2.3	-1.5	1.4
Reaction time trials on left	1.4	2.0	2.1	-1.4	1.4
Reaction time mean	1.8	2.5	2.6	1.6	-1.6
Reaction time mean AUC	0.9	1.2	1.3	1.1	-1.1
Median of all reaction times	0.9	1.2	1.3	1.1	-1.1
Reaction time omissions	0.0	0.0	0.0	0.1	-0.0
Reaction time false alarm rate	0.1	0.1	0.1	-0.3	0.3
Reaction time premature initiation rate	0.7	0.9	1.1	0.9	-1.0
Reaction time premature initiations	0.0	0.0	0.1	0.0	-0.2
Std. dev. reaction times	1.4	2.0	2.3	1.3	-1.5
Reaction time trials completed	1.4	2.0	2.1	-1.4	1.4
Reaction time trials AUC	1.7	2.4	2.5	-1.6	1.5
Social response proportion	1.4	1.5	1.6	1.3	-1.2
Social responses	11.4	14.7	14.8	3.8	-3.8
Social time	1.0	1.4	1.6	-1.2	1.1
Conditioned locomotion	1.7	2.1	2.1	-1.4	1.4
Cocaine response after cond. corrected	3.8	4.2	4.3	-2.1	2.1
Cocaine response after cond. not corrected	3.9	4.3	4.5	-2.1	2.1
Cocaine response before conditioning	0.8	0.9	1.0	0.9	-1.0
Saline control response	0.4	0.6	0.7	-0.8	0.7
Condit. Reinf. active minus inactive responses	0.9	1.1	1.3	1.1	-1.0
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	-0.0
Condit. Reinf. active responses	1.0	1.4	1.5	1.2	-1.1
Condit. Reinf. inactive responses	0.5	0.7	0.7	0.8	-0.8
Condit. Reinf. lever presses	1.7	2.3	2.4	1.5	-1.5
Condit. Reinf. lever reinforcers received	0.6	0.8	0.9	1.0	-0.9
Pavlov. Cond. lever latency	1.6	2.2	2.2	-1.5	1.5
Pavlov. Cond. magazine entry latency	2.4	2.8	3.0	1.7	-1.6
Pavlov. Cond. change in total contacts	0.6	0.8	0.8	0.9	-0.8
Pavlov. Cond. index score	1.8	2.3	2.5	1.6	-1.4
Pavlov. Cond. latency score	2.2	2.8	3.0	1.7	-1.6
Pavlov. Cond. lever contacts	1.0	1.4	1.5	1.2	-1.1
Pavlov. Cond. magazine entry number	2.1	2.5	2.8	-1.7	1.5
Pavlov. Cond. intertrial magazine entries	1.1	1.4	1.8	-1.3	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.5	2.7	1.6	-1.5
Pavlov. Cond. response bias	1.6	2.1	2.3	1.5	-1.4
Conditioned reinforcement - actives	0.1	0.1	0.2	0.3	-0.5
Conditioned reinforcement - inactives	2.1	2.4	2.7	-1.7	1.4
Conditioned locomotion	2.3	2.8	2.9	1.6	-1.7
Intermittent access intake day 1-15 change	0.1	0.0	0.1	0.2	-0.3
Intermittent access intake escalation	0.1	0.1	0.2	-0.4	0.3
Intermittent access intake escalation 2	0.0	0.0	0.0	0.1	-0.1
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.4	-0.5	0.6
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.2	0.4	-0.4
Intermitt. access escalation Index	0.4	0.3	0.4	0.6	-0.6
Intermittent access day 1 total infusions	0.2	0.2	0.2	-0.5	0.4
Intermittent access day 15 total infusions	0.3	0.3	0.4	-0.6	0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	-0.3	0.2
Intermittent access total infusions	0.3	0.4	0.5	-0.7	0.5
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	0.0
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.3	-0.4
Intermittent access total locomotion	0.2	0.3	0.3	0.5	-0.5
Intermittent access standard deviation	0.0	0.0	0.0	-0.0	-0.1
Cocaine induced anxiety	2.9	3.4	3.6	1.8	-1.9
Post-drug Anxiety	1.4	1.5	1.5	1.2	-1.2
Baseline Anxiety	0.2	0.2	0.3	-0.2	0.5
Lifetime Intake	0.6	0.7	0.9	-0.9	0.7
Incentive Sensitization - Responses	0.1	0.1	0.1	0.3	-0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.3	0.4	-0.6
Progressive ratio test 1 active lever presses	1.4	1.4	1.7	-1.3	1.1
Progressive ratio test 1 breakpoint	1.3	1.4	1.6	-1.3	1.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.1	0.0
Progressive ratio test 2 active lever presses	0.4	0.4	0.6	-0.7	0.5
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.2	-0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	-0.4	0.3
Total sessions with >9 infusions	0.0	0.0	0.0	0.0	-0.2
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.1	0.2
Short access day 10 total inactive lever presses	0.4	0.4	0.6	-0.5	0.8
Short access day 1 total infusions	0.1	0.1	0.1	-0.4	0.1
Short access day 10 total infusions	0.5	0.6	0.8	-0.9	0.6
Short access total infusions	0.5	0.6	0.7	-0.9	0.6
Short access day 1 locomotion	0.2	0.2	0.2	0.4	-0.5
Short access day 10 total locomotion	0.6	0.6	0.6	0.8	-0.8
Short access total locomotion	0.2	0.2	0.2	0.4	-0.5
Compulsive drug intake	0.1	0.1	0.1	-0.3	0.3
One hour access (0.3 mA shock)	0.3	0.3	0.4	-0.6	0.5
One hour access (shock baseline)	0.3	0.3	0.4	-0.6	0.5
Number of responses in last shaping day	0.8	0.8	0.9	0.8	-0.9
Context. condit. distance diff. score	0.3	0.3	0.3	-0.6	0.6
Locomotion velocity, session 1	0.1	0.1	0.1	0.4	-0.4
Locomotion distance, session 1	0.7	0.9	1.0	1.0	-0.9
Locomotion velocity, session 2	2.5	3.0	3.1	1.7	-1.8
Locomotion distance, session 2	4.2	6.0	6.3	2.5	-2.4
Locomotion velocity, session 3	4.6	5.3	5.4	2.3	-2.3
Locomotion distance, session 3	0.0	0.0	0.0	0.2	-0.2
Stereotopy head waving bouts, day 3	5.7	6.9	7.4	2.7	-2.5
Stereotopy head waving duration, day 3	3.5	4.3	4.4	2.1	-2.0
Locomotion velocity, session 7	0.2	0.2	0.3	0.4	-0.6
Locomotion distance, session 7	0.3	0.3	0.3	-0.6	0.6
Stereotopy head waving bouts, day 7	1.7	2.0	2.0	1.4	-1.4
Stereotopy head waving duration, day 7	1.7	2.0	2.1	1.4	-1.4
Locomotion velocity, session 8	3.0	3.5	3.7	1.8	-1.9
Locomotion distance, session 8	0.5	0.7	0.8	0.9	-0.8
Degree of sensitization distance	0.5	0.6	0.6	-0.7	0.8
Degree of sensitization stereotypy	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. active minus inactive responses	2.0	2.2	2.4	1.4	-1.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.2	-0.4
Condit. Reinf. active responses	3.4	4.1	4.3	2.1	-2.0
Condit. Reinf. inactive responses	2.1	2.5	3.0	1.7	-1.4
Incentive salience index mean	2.0	2.3	2.5	1.5	-1.6
Condit. Reinf. lever presses	1.2	1.6	1.8	1.2	-1.3
Time in familiar zone, hab. session 1	4.0	3.8	3.9	2.0	-1.9
Time in novel zone, hab. session 1	1.8	1.7	1.8	-1.4	1.3
Total zone transitions, hab. session 1	1.1	1.5	1.6	1.3	-1.2
Total locomotion distance, hab. session 1	3.4	4.9	4.9	2.2	-2.2
Locomotion velocity, hab. session 1	3.1	4.5	4.6	2.1	-2.1
Time in familiar zone, hab. session 2	3.0	3.2	3.2	1.8	-1.8
Time in novel zone, hab. session 2	3.2	3.2	3.2	-1.8	1.8
Total zone transitions, hab. session 2	0.0	0.0	0.0	0.0	0.1
Total locomotion distance, hab. session 2	0.8	1.1	1.1	1.1	-1.1
Locomotion velocity, hab. session 2	1.2	1.6	1.6	1.2	-1.2
Novel to familiar place preference ratio	1.1	1.2	1.2	-1.1	1.1
Novelty place preference	0.6	0.7	0.7	-0.8	0.8
Time in novel zone, NPP test	1.1	1.2	1.2	-1.1	1.1
Total zone transitions, NPP test	0.0	0.0	0.0	-0.1	0.2
Total locomotion distance, NPP test	0.1	0.1	0.1	0.4	-0.3
Locomotion velocity, NPP test	0.3	0.4	0.5	0.7	-0.7
Pavlov. Cond. lever latency	0.4	0.5	0.5	-0.7	0.7
Pavlov. Cond. magazine entry latency	1.3	1.6	1.7	1.3	-1.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	0.3
Pavlov. Cond. index score	0.8	1.1	1.1	1.0	-1.1
Pavlov. Cond. latency score	1.1	1.4	1.5	1.1	-1.2
Pavlov. Cond. lever contacts	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. magazine entry number	0.5	0.7	0.7	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.3	1.1	-1.2
Pavlov. Cond. response bias	0.9	1.1	1.2	1.0	-1.1
Bone: apparent density	0.6	1.0	1.0	1.0	-1.0
Bone surface	1.9	3.3	3.4	1.8	-1.8
Bone volume	1.6	2.6	2.7	1.6	-1.7
Bone: connectivity density	0.4	0.6	0.6	0.8	-0.7
Bone: cortical apparent density	1.7	2.2	2.2	-1.5	1.5
Bone: cortical area	0.2	0.3	0.3	-0.5	0.5
Bone: cortical porosity	0.1	0.1	0.1	0.3	-0.2
Bone: cortical porosity	0.0	0.0	0.0	0.1	-0.0
Bone: cortical thickness	1.0	1.6	1.8	-1.2	1.4
Bone: cortical thickness	1.2	1.4	1.6	-1.2	1.2
Bone: cortical tissue density	1.3	1.7	1.7	-1.3	1.3
Bone: elastic displacement	0.0	0.0	0.0	0.1	-0.0
Bone: elastic work	0.2	0.2	0.3	-0.5	0.5
Bone: endosteal estimation	0.2	0.5	0.7	-0.8	0.6
Bone: endosteal perimeter	0.5	1.0	1.1	1.0	-0.9
Bone: final force	1.2	2.0	2.0	-1.4	1.4
Bone: final moment	1.1	1.8	1.9	-1.4	1.3
Bone: marrow area	0.2	0.4	0.6	-0.8	0.5
Bone: maximum diameter	0.8	1.5	1.7	1.1	-1.3
Bone: maximum force	1.5	2.6	2.7	-1.6	1.6
Bone: maximum moment	1.4	2.4	2.6	-1.6	1.5
Bone: minimum diameter	0.0	0.0	0.0	-0.2	0.0
Bone: periosteal estimation	0.2	0.4	0.5	-0.7	0.6
Bone: periosteal perimeter	0.1	0.2	0.3	0.5	-0.4
Bone: post-yield work	0.3	0.4	0.5	-0.7	0.5
Bone: stiffness	3.2	5.0	5.2	-2.3	2.2
Bone: tissue strength	3.2	3.1	3.2	-1.8	1.7
Bone: trabecular number	1.7	2.7	2.7	1.7	-1.6
Bone: trabecular spacing	1.7	2.2	2.3	-1.5	1.5
Bone: trabecular thickness	1.2	1.4	1.6	1.1	-1.3
Bone: trabecular tissue density	7.3	10.2	10.6	-3.3	3.1
Breakpoint value in progressive ratio session	1.4	1.5	1.6	1.3	-1.2
Distance traveled before self-admin	1.3	1.4	1.4	1.2	-1.2
Distance traveled after self-admin	0.3	0.4	0.4	0.6	-0.6
Delta time in closed arm before/after self-admin	3.1	3.0	3.3	-1.7	1.8
Delta time in open arm before/after self-admin	0.5	0.5	0.7	-0.8	0.5
Diff in mean of infusions in LGA sessions	1.6	1.8	1.9	1.4	-1.3
Extinction: sum of active levers before priming	1.5	1.5	1.5	1.2	-1.2
Active lever presses in extinction session 6	1.5	1.4	1.7	1.3	-1.1
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.1	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	0.0	0.0
Time in closed arm before self-admin	0.0	0.0	0.1	0.2	-0.2
Time in closed arm after self-admin	0.4	0.4	0.5	-0.6	0.7
Time in open arm before self-admin	0.0	0.0	0.0	0.1	-0.1
Time in open arm after self-admin	1.1	1.2	1.4	-1.2	1.0
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.5	-0.3
Time to tail flick, vehicle, before self-admin	2.9	3.0	3.0	1.7	-1.7
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	-0.1
Time to tail flick, test, before self-admin	1.8	1.8	1.9	1.3	-1.4
Time to tail flick, test, after self-admin	0.5	0.5	0.6	0.7	-0.8
Delta time to tail flick, vehicle, before/after SA	2.1	2.1	2.1	-1.4	1.4
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.0	-0.0
Ambulatory time before self-admin	0.3	0.3	0.4	0.6	-0.6
Ambulatory time after self-admin	0.1	0.1	0.1	0.3	-0.3
Total heroin consumption	2.5	3.0	3.5	1.9	-1.6
Area under the delay curve	0.0	0.0	0.0	0.1	-0.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.4	0.3
Delay disc. indifference point, 16s delay	0.3	0.3	0.3	0.6	-0.6
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.1	-0.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.3	0.3
Delay disc. indifference point, 4s delay	0.9	0.9	1.0	1.0	-1.0
Delay disc. indifference point, 8s delay	0.2	0.2	0.2	-0.5	0.4
Delay discount exponential model param	0.0	0.0	0.0	-0.2	0.2
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.0	0.1
Fecal boli incidents, locomotor time 1	1.5	1.6	2.0	-1.1	1.4
Change in fecal boli incidents, locomotor task	1.8	1.7	2.2	1.1	-1.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.3	0.4
Bouts of movement, locomotor time 1	0.3	0.3	0.3	0.6	-0.5
Total resting periods, locomotor time 1	0.9	1.0	1.1	1.1	-1.0
Rest time, locomotor task time 1	0.8	0.8	0.9	0.9	-1.0
Distance moved, locomotor task time 1	0.2	0.2	0.2	-0.4	0.5
Vertical activity count, locomotor time 1	1.4	1.5	1.7	-1.3	1.1
Time >=10cm from walls, locomotor time 2	1.9	2.0	2.3	-1.3	1.5
Bouts of movement, locomotor time 2	0.6	0.7	0.7	0.9	-0.8
Total resting periods, locomotor time 2	0.7	0.7	0.8	0.9	-0.8
Rest time, locomotor task time 2	0.4	0.4	0.6	0.5	-0.8
Distance moved, locomotor task time 2	0.3	0.4	0.5	-0.5	0.7
Vertical activity count, locomotor time 2	2.5	2.8	2.8	-1.7	1.6
Weight adjusted by age	0.1	0.1	0.1	-0.3	0.3
Seeking ratio, delayed vs. immediate footshock	1.8	2.0	2.2	1.4	-1.5
Locomotion in novel chamber	0.3	0.4	0.5	-0.5	0.7
Locomotion in novel chamber post-restriction	3.1	3.6	3.9	2.0	-1.9
Progressive ratio	1.5	1.7	1.9	-1.4	1.2
Food seeking constrained by brief footshock	1.5	1.8	1.9	1.4	-1.3
Seeking ratio, punishment vs. effort	2.3	2.8	3.0	1.7	-1.6
Run reversals in cocaine runway, females	2.2	2.2	2.4	1.6	-1.4
Run reversals in cocaine runway, males	2.9	2.8	2.8	1.7	-1.7
Latency to leave start box in cocaine runway	0.3	0.3	0.3	0.5	-0.6
Latency to leave start box in cocaine runway, F	0.3	0.4	0.4	0.6	-0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	0.3
Cd content in liver	0.5	0.5	0.5	-0.7	0.7
Co content in liver	0.5	0.6	0.7	0.8	-0.7
Cu content in liver	0.4	0.5	0.5	-0.7	0.7
Fe content in liver	0.9	1.1	1.1	-1.0	1.0
K content in liver	1.1	1.1	1.3	1.0	-1.1
Mg content in liver	1.0	1.0	1.1	1.0	-1.0
Mn content in liver	1.9	2.2	2.3	1.5	-1.4
Na content in liver	0.0	0.0	0.0	0.1	-0.1
Rb content in liver	0.1	0.1	0.2	-0.3	0.4
Se content in liver	0.1	0.1	0.1	0.4	-0.3
Sr content in liver	0.0	0.0	0.0	-0.2	0.2
Zn content in liver	0.4	0.4	0.5	0.7	-0.6