Yif1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000020201	0.14	0.06	2.9e-14	0.1	0.08	0.09	0.08	8.4e-11	2.7e-09	7.8e-10	1.6e-09
2	LHb	isoform ratio	ENSRNOT00000078657	0.12	0.09	6.8e-03	0.07	0.09	0.07	0.08	1.1e-02	4.4e-03	8.8e-03	5.3e-03
3	Liver	alternative polyA	ENSRNOT00000027406	0.05	0.03	1.0e-04	0.02	0.02	0.01	0.02	6.2e-03	1.1e-03	6.6e-02	6.4e-03
4	Liver	alternative polyA	ENSRNOT00000078657	0.03	0.02	6.5e-03	0	0.01	-0	0	1.6e-01	4.2e-02	6.9e-01	8.5e-02
5	NAcc	gene expression	ENSRNOG00000020201	0.06	0.05	7.3e-03	0.03	0.02	0.02	0.02	1.4e-03	1.4e-02	1.3e-02	7.5e-03
6	PL	gene expression	ENSRNOG00000020201	0.07	0.05	1.3e-03	0.03	0.03	0.02	0.02	2.8e-03	4.0e-03	1.4e-02	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	4.2	13.5	28.6	-2.7	-0.7	4.1	-3.9	-3.6	-5.3
BMI without tail	1.8	3.7	9.7	-1.3	-0.3	2.0	-1.9	-1.6	-3.1
Body weight	3.1	12.9	19.3	-4.0	-3.2	4.3	-4.4	-2.1	-2.9
Epididymis fat weight	1.8	4.2	7.5	2.5	2.7	-2.3	2.4	0.5	0.2
Glucose	1.4	2.1	6.0	1.8	2.4	-1.0	1.2	-0.9	-0.7
Heart weight	1.8	2.6	5.1	1.8	2.3	-1.9	2.0	0.2	0.2
Left kidney weight	0.6	1.6	2.6	1.4	0.9	-1.6	1.6	1.1	0.6
Right kidney weight	0.3	0.7	1.7	0.7	-0.1	-1.0	0.9	0.6	1.3
Tail length	0.6	1.9	5.2	-1.0	-2.3	0.3	-0.5	1.7	1.3
Length with tail	1.5	5.4	12.6	-2.9	-3.6	2.2	-2.4	0.3	0.7
Length without tail	1.9	4.2	6.5	-2.5	-2.5	2.4	-2.5	-0.7	-0.1
Liver weight, left	0.1	0.2	0.7	0.4	0.2	-0.5	0.5	0.8	0.1
Liver weight, right	0.1	0.2	0.9	0.5	0.1	-0.4	0.4	0.9	0.1
Parametrial fat weight	1.6	3.2	7.3	2.2	2.7	-1.6	1.8	-0.3	-0.9
Retroperitoneal fat weight	3.7	12.2	21.5	4.6	4.3	-3.9	4.1	0.9	0.8
Intraocular pressure	0.9	1.3	3.3	0.4	0.3	-1.4	1.4	0.6	1.8
Extensor digitorum longus weight	5.7	22.7	33.6	-5.8	-5.2	5.5	-5.7	-1.9	-3.1
Soleus weight	3.7	10.7	17.8	4.2	3.0	-3.8	3.9	2.4	1.2
Tibialis anterior weight	7.2	24.7	44.1	-6.5	-6.6	5.3	-5.7	-0.7	-1.1
Tibia length	0.6	1.7	4.4	-1.4	-2.1	1.2	-1.4	-0.2	0.6
Number of licking bursts	0.3	0.3	0.5	-0.6	-0.5	0.7	-0.7	-0.6	-0.3
Food consumed during 24 hour testing period	0.2	0.3	1.4	-0.1	-0.4	-0.1	0.1	-0.1	1.2
Times rat made contact with spout	0.5	0.6	0.9	-0.6	-0.3	1.0	-0.9	-0.9	-0.7
Mean time between licks in bursts	0.2	0.3	0.6	-0.4	-0.8	0.5	-0.6	0.5	-0.3
Mean num. licks in bursts	0.1	0.1	0.3	0.5	0.6	-0.3	0.3	0.0	-0.1
Std. dev. time between licks in bursts	0.6	0.8	3.4	0.2	-0.3	-0.7	0.6	1.9	0.3
Water consumed over 24 hours	0.6	0.7	1.0	-1.0	-0.8	1.0	-1.0	-0.7	0.1
Indifference point 0 sec	0.1	0.1	0.2	0.2	0.5	-0.0	0.1	-0.5	-0.1
Indifference point AUC	2.7	3.2	5.5	-2.4	-2.1	2.0	-2.1	-0.8	-0.4
Indifference point function ln k	6.8	9.6	14.9	3.9	3.0	-3.6	3.7	2.3	1.1
Indifference point function log k	6.8	9.6	14.9	3.9	3.0	-3.6	3.7	2.3	1.1
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	0.2	0.1	-0.2	0.2	0.1	0.2
Delay discounting total patch changes 12 sec	4.1	5.4	8.1	-2.7	-2.1	2.8	-2.8	-1.6	-1.5
Delay discounting total patch changes 18 sec	0.8	1.0	1.7	-1.3	-0.5	1.1	-1.1	-1.1	-0.7
Delay discounting total patch changes 24 sec	1.5	1.9	3.4	-1.7	-1.8	1.6	-1.7	-0.4	-0.2
Delay discounting total patch changes 6 sec	1.3	2.0	2.9	-1.6	-0.9	1.7	-1.7	-1.2	-1.0
Delay discounting time to switch 0 sec	3.2	4.9	7.1	-1.8	-0.6	2.5	-2.4	-2.7	-2.6
Delay discounting water rate 0 sec	5.1	8.2	11.6	2.7	1.3	-3.4	3.3	2.9	2.9
Delay discounting water rate 12 sec	9.9	14.8	20.7	4.0	2.3	-4.5	4.5	3.9	3.5
Delay discounting water rate 18 sec	3.4	4.5	6.5	2.5	1.5	-2.5	2.5	2.0	1.4
Delay discounting water rate 24 sec	5.2	7.2	10.4	2.8	1.5	-3.2	3.2	2.8	2.2
Delay discounting water rate 6 sec	4.6	6.6	9.2	2.6	1.2	-3.0	2.9	2.9	2.3
Locomotor activity	2.2	3.5	4.7	1.9	0.8	-2.1	2.1	2.2	1.8
Locomotor testing distance	2.9	4.9	6.2	2.4	1.1	-2.5	2.4	2.5	2.1
Locomotor testing rearing	1.7	2.7	3.5	1.9	1.6	-1.8	1.9	1.2	1.2
Light reinforcement 1	0.2	0.4	0.6	0.8	0.4	-0.7	0.7	0.5	0.7
Light reinforcement 2	0.9	1.1	1.9	1.4	0.8	-1.2	1.2	0.0	1.1
Reaction time number correct	0.3	0.5	1.1	-0.8	-1.1	0.2	-0.3	0.5	0.7
Reaction time mean minus median	2.7	3.5	5.0	-2.1	-1.7	2.2	-2.2	-1.6	-0.8
Reaction time mean minus median AUC	1.3	1.6	2.9	-1.6	-1.7	1.4	-1.5	-0.5	0.0
Reaction time num false alarms	0.5	0.7	2.7	0.5	-0.2	-0.8	0.7	1.6	0.3
Reaction time num false alarms AUC	0.3	0.4	1.4	-0.2	-0.8	-0.1	-0.0	1.2	0.0
Reaction time trials correct on left	0.3	0.5	1.1	-0.8	-1.1	0.2	-0.3	0.5	0.7
Reaction time trials on left	0.4	0.6	1.5	-0.9	-1.2	0.3	-0.4	0.6	0.8
Reaction time mean	0.0	0.0	0.1	-0.0	-0.1	0.2	-0.2	-0.3	0.3
Reaction time mean AUC	0.0	0.1	0.2	0.1	0.1	0.2	-0.2	-0.5	0.1
Median of all reaction times	0.1	0.1	0.2	0.4	0.4	-0.2	0.3	-0.2	0.2
Reaction time omissions	1.1	1.5	2.6	-1.6	-1.5	1.4	-1.4	-0.4	-0.4
Reaction time false alarm rate	0.2	0.3	1.0	0.5	-0.0	-0.5	0.5	1.0	-0.1
Reaction time premature initiation rate	1.2	1.6	3.5	-1.3	-1.9	1.4	-1.5	0.3	-0.2
Reaction time premature initiations	2.0	2.9	7.2	-1.9	-2.7	1.7	-1.9	0.5	0.2
Std. dev. reaction times	0.7	0.9	1.3	-1.1	-1.0	1.1	-1.1	-0.9	-0.1
Reaction time trials completed	0.4	0.6	1.5	-0.9	-1.2	0.3	-0.4	0.6	0.8
Reaction time trials AUC	0.3	0.4	0.9	-0.7	-1.0	0.1	-0.2	0.6	0.7
Social response proportion	0.9	1.0	2.2	-0.6	-0.5	1.2	-1.2	-1.5	-0.4
Social responses	0.2	0.2	0.4	-0.6	-0.6	0.5	-0.5	-0.2	0.3
Social time	0.2	0.3	0.6	-0.7	-0.8	0.5	-0.5	0.0	0.5
Conditioned locomotion	1.2	1.4	3.1	-1.6	-1.8	1.1	-1.2	0.3	-0.4
Cocaine response after cond. corrected	0.9	1.0	1.7	1.0	1.1	-1.3	1.3	0.8	0.3
Cocaine response after cond. not corrected	0.7	0.7	1.1	0.9	1.1	-1.0	1.1	0.4	0.2
Cocaine response before conditioning	0.6	0.7	1.2	-0.8	-0.6	1.0	-1.0	-1.1	-0.3
Saline control response	2.7	3.6	6.0	-2.1	-1.9	2.4	-2.4	-1.1	-1.1
Condit. Reinf. active minus inactive responses	0.3	0.4	1.3	0.5	0.8	0.0	0.1	-1.1	-0.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.1	1.0	1.1	-0.5	0.6	-0.6	0.1
Condit. Reinf. active responses	0.7	0.9	3.3	-0.1	0.6	0.8	-0.7	-1.8	-0.8
Condit. Reinf. inactive responses	1.0	1.3	2.6	-0.8	0.2	1.2	-1.1	-1.6	-1.3
Condit. Reinf. lever presses	2.3	3.2	4.8	-1.9	-1.3	2.2	-2.2	-2.0	-0.8
Condit. Reinf. lever reinforcers received	0.8	1.1	3.7	-0.4	0.3	1.1	-1.0	-1.9	-0.7
Pavlov. Cond. lever latency	0.5	0.7	1.0	0.9	0.6	-1.0	1.0	1.0	0.5
Pavlov. Cond. magazine entry latency	3.8	4.4	6.8	-2.1	-1.5	2.6	-2.6	-2.1	-1.5
Pavlov. Cond. change in total contacts	2.3	3.2	5.9	-1.5	-1.0	2.1	-2.1	-2.4	-1.0
Pavlov. Cond. index score	2.5	3.3	4.9	-1.7	-1.3	2.2	-2.2	-2.0	-1.2
Pavlov. Cond. latency score	2.1	2.7	4.0	-1.5	-1.2	2.0	-2.0	-1.8	-1.1
Pavlov. Cond. lever contacts	0.4	0.5	0.8	-0.8	-0.9	0.8	-0.8	-0.6	0.2
Pavlov. Cond. magazine entry number	6.1	7.5	11.4	2.8	2.1	-3.4	3.4	2.7	1.6
Pavlov. Cond. intertrial magazine entries	1.0	1.3	2.1	1.2	1.1	-1.4	1.5	0.8	0.7
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.9	5.8	-1.9	-1.5	2.4	-2.4	-2.1	-1.3
Pavlov. Cond. response bias	1.6	2.2	3.3	-1.5	-1.3	1.8	-1.8	-1.5	-0.5
Conditioned reinforcement - actives	0.3	0.3	0.7	0.5	0.2	-0.6	0.6	0.4	0.8
Conditioned reinforcement - inactives	4.2	4.8	7.1	2.5	2.3	-2.6	2.7	0.8	1.7
Conditioned locomotion	7.5	9.0	12.9	3.4	2.4	-3.6	3.6	2.3	2.4
Intermittent access intake day 1-15 change	0.8	0.8	2.2	0.6	0.0	-1.0	1.0	0.7	1.5
Intermittent access intake escalation	0.5	0.5	1.1	0.6	0.3	-0.8	0.8	0.4	1.0
Intermittent access intake escalation 2	0.5	0.5	1.5	0.3	-0.2	-0.8	0.7	0.7	1.2
Intermitt. access day 1 inactive lever presses	1.3	1.4	2.3	1.3	1.5	-1.4	1.5	0.1	0.6
Intermitt. access day 15 inactive lever presses	1.3	1.4	1.9	1.4	1.3	-1.3	1.4	-0.1	1.1
Intermitt. access escalation Index	2.7	2.4	4.9	2.0	2.2	-1.5	1.7	0.6	-0.4
Intermittent access day 1 total infusions	3.5	3.9	11.7	2.3	3.4	-1.4	1.7	-1.1	-0.7
Intermittent access day 15 total infusions	4.6	5.2	9.4	2.8	3.1	-2.4	2.6	0.0	1.0
Intermittent access terminal intake (last 3 days)	3.0	3.3	7.2	2.2	2.7	-1.8	2.0	-0.4	0.6
Intermittent access total infusions	2.5	2.7	7.7	1.9	2.8	-1.3	1.5	-1.0	-0.2
Intermittent access day 1 locomotion	2.4	2.5	7.7	1.6	2.8	-0.8	1.1	-1.2	-1.1
Intermittent access day 15 total locomotion	2.7	2.9	5.9	2.1	2.4	-1.7	1.9	-0.2	0.6
Intermittent access total locomotion	3.8	4.3	11.7	2.6	3.4	-1.6	1.9	-1.1	-0.5
Intermittent access standard deviation	0.9	1.0	1.4	0.9	0.7	-1.2	1.2	0.7	1.2
Cocaine induced anxiety	0.0	0.0	0.2	-0.1	-0.2	-0.1	0.1	0.1	0.4
Post-drug Anxiety	1.0	1.1	2.6	-1.4	-1.6	0.8	-1.0	-0.1	0.6
Baseline Anxiety	1.6	1.7	3.5	-1.6	-1.9	1.4	-1.5	-0.2	-0.1
Lifetime Intake	2.1	2.4	7.3	1.7	2.7	-1.1	1.3	-1.0	-0.4
Incentive Sensitization - Responses	0.3	0.3	0.5	0.6	0.7	-0.2	0.3	-0.7	0.1
Incentive Sensitization - Breakpoint	0.3	0.3	0.7	0.8	0.8	-0.4	0.5	-0.6	0.2
Progressive ratio test 1 active lever presses	1.6	1.7	3.1	1.5	1.8	-1.4	1.5	0.1	0.7
Progressive ratio test 1 breakpoint	1.5	1.5	2.4	1.3	1.6	-1.4	1.5	0.3	0.8
Progressive ratio test 1 inactive lever presses	0.7	0.7	1.7	1.0	1.3	-0.8	0.9	-0.1	0.1
Progressive ratio test 2 active lever presses	2.4	2.6	4.6	2.0	2.1	-1.7	1.8	-0.1	0.9
Progressive ratio test 2 breakpoint	3.4	3.8	5.4	2.3	2.2	-2.2	2.3	0.6	1.4
Progressive ratio test 2 inactive lever presses	5.2	6.0	11.7	3.0	3.4	-2.6	2.8	0.0	0.9
Total sessions with >9 infusions	0.9	1.0	2.9	1.1	1.7	-0.8	0.9	-0.4	-0.6
Short access day 1 total inactive lever presses	2.4	2.7	5.0	1.9	2.2	-1.8	1.9	0.4	0.3
Short access day 10 total inactive lever presses	2.4	2.6	4.0	1.9	1.7	-1.9	2.0	0.9	0.8
Short access day 1 total infusions	2.0	2.2	6.6	1.6	2.6	-1.0	1.2	-0.8	-1.0
Short access day 10 total infusions	2.0	2.2	5.2	0.8	2.3	0.2	0.1	-2.1	-1.7
Short access total infusions	1.1	1.2	3.7	0.8	1.9	-0.3	0.5	-1.1	-1.1
Short access day 1 locomotion	1.4	1.5	4.8	1.3	2.2	-0.6	0.8	-1.0	-0.8
Short access day 10 total locomotion	1.2	1.3	3.8	1.2	2.0	-0.4	0.6	-1.1	-0.9
Short access total locomotion	1.1	1.1	3.4	0.9	1.8	-0.3	0.5	-1.0	-1.0
Compulsive drug intake	1.6	1.6	3.7	-1.6	-1.9	1.2	-1.4	0.5	-0.1
One hour access (0.3 mA shock)	6.3	7.4	10.7	3.2	3.3	-3.1	3.2	0.6	1.7
One hour access (shock baseline)	5.4	6.3	10.0	3.0	3.2	-2.8	3.0	0.1	1.5
Number of responses in last shaping day	1.0	1.1	1.5	1.0	0.8	-1.2	1.2	1.0	0.9
Context. condit. distance diff. score	1.5	1.8	3.1	1.8	1.5	-1.5	1.6	0.7	-0.2
Locomotion velocity, session 1	0.2	0.3	1.0	0.2	-0.3	-0.3	0.3	1.0	0.4
Locomotion distance, session 1	1.0	1.3	2.8	-0.3	0.1	1.3	-1.2	-1.2	-1.7
Locomotion velocity, session 2	2.4	2.9	4.1	-1.9	-1.4	2.0	-2.0	-0.9	-1.6
Locomotion distance, session 2	0.9	1.2	2.0	-0.7	-0.4	1.4	-1.4	-0.9	-1.4
Locomotion velocity, session 3	0.3	0.3	1.2	0.4	0.6	0.1	-0.1	-0.4	-1.1
Locomotion distance, session 3	0.0	0.0	0.0	0.2	0.1	-0.1	0.1	-0.0	0.1
Stereotopy head waving bouts, day 3	0.5	0.6	1.6	1.0	1.3	-0.5	0.6	-0.1	-0.7
Stereotopy head waving duration, day 3	0.7	0.8	2.1	1.2	1.4	-0.8	0.9	-0.1	-0.3
Locomotion velocity, session 7	0.9	0.9	3.9	0.4	1.1	0.1	0.0	-0.6	-2.0
Locomotion distance, session 7	0.2	0.3	1.7	-0.1	0.3	0.2	-0.2	0.1	-1.3
Stereotopy head waving bouts, day 7	0.4	0.4	1.5	0.0	0.9	0.0	0.1	-1.2	-0.5
Stereotopy head waving duration, day 7	1.8	2.2	4.8	-1.4	-0.2	1.6	-1.5	-2.2	-1.3
Locomotion velocity, session 8	0.5	0.6	1.5	-0.8	-1.2	0.8	-0.9	0.2	-0.0
Locomotion distance, session 8	0.3	0.4	0.9	0.9	0.8	-0.3	0.3	-0.0	-0.9
Degree of sensitization distance	0.3	0.3	1.6	-0.2	0.3	0.4	-0.3	-0.3	-1.3
Degree of sensitization stereotypy	1.0	1.1	2.5	-1.2	-0.2	1.0	-1.0	-1.6	-0.7
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	-0.5	-0.1	0.7	-0.7	-0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.0	0.1	0.3	-0.3	-0.6	-0.1
Condit. Reinf. active responses	0.3	0.4	0.9	-0.6	-0.1	0.6	-0.5	-0.6	-0.9
Condit. Reinf. inactive responses	0.2	0.2	1.1	-0.3	0.2	0.2	-0.1	-0.2	-1.0
Incentive salience index mean	0.7	0.8	1.8	-0.6	-0.2	0.9	-0.9	-0.9	-1.3
Condit. Reinf. lever presses	0.4	0.5	1.2	-0.7	-0.5	0.7	-0.7	-0.4	-1.1
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.7	0.8	-0.1	0.2	-0.6	-0.6
Time in novel zone, hab. session 1	0.7	0.7	1.7	0.3	-0.0	-0.8	0.7	1.3	1.1
Total zone transitions, hab. session 1	0.7	1.0	1.5	-0.9	-0.8	1.2	-1.2	-0.6	-1.2
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.6	0.8	-0.5	0.5	0.0	-0.7
Locomotion velocity, hab. session 1	0.1	0.1	0.6	0.2	0.3	0.0	0.0	-0.2	-0.8
Time in familiar zone, hab. session 2	0.3	0.3	1.0	-0.1	-0.4	-0.3	0.3	1.0	0.6
Time in novel zone, hab. session 2	0.4	0.4	1.3	-0.2	0.4	0.6	-0.5	-1.1	-0.8
Total zone transitions, hab. session 2	3.2	4.1	7.5	-1.1	0.2	2.2	-2.1	-2.6	-2.7
Total locomotion distance, hab. session 2	0.8	1.1	3.3	0.2	1.0	0.5	-0.4	-1.3	-1.8
Locomotion velocity, hab. session 2	0.8	1.1	3.0	0.5	1.2	0.4	-0.2	-1.3	-1.7
Novel to familiar place preference ratio	1.2	1.3	2.4	-1.2	-0.5	1.3	-1.3	-1.5	-0.7
Novelty place preference	0.7	0.7	2.0	-0.7	-0.1	0.9	-0.9	-1.4	-0.5
Time in novel zone, NPP test	0.6	0.6	1.6	-0.7	-0.0	0.8	-0.8	-1.3	-0.5
Total zone transitions, NPP test	2.0	2.8	4.3	-1.3	-1.0	2.1	-2.0	-1.4	-2.0
Total locomotion distance, NPP test	0.3	0.4	1.8	0.1	0.2	0.4	-0.4	-0.4	-1.4
Locomotion velocity, NPP test	0.3	0.4	1.7	0.1	0.1	0.5	-0.4	-0.4	-1.3
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.5	0.3	-0.6	0.6	0.5	0.7
Pavlov. Cond. magazine entry latency	0.7	0.9	2.4	-0.2	0.5	0.8	-0.7	-1.5	-1.2
Pavlov. Cond. change in total contacts	0.3	0.4	1.3	0.1	0.3	0.4	-0.4	-1.2	-0.7
Pavlov. Cond. index score	0.1	0.1	0.3	-0.2	-0.1	0.4	-0.3	-0.5	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.1	0.1	0.3	-0.2	-0.5	-0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.2	0.0	0.1	-0.1	-0.1	-0.4
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.5	0.4	-0.4	0.4	0.5	-0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.8	0.2	0.1	-0.7	0.7	0.5	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	-0.4	-0.3	0.6	-0.6	-0.7	-0.4
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.3	-0.2	0.3	-0.3	-0.4	0.1
Bone: apparent density	1.9	3.2	7.5	-1.1	0.5	1.7	-1.6	-2.7	-2.1
Bone surface	4.7	8.3	12.2	-3.0	-1.3	3.5	-3.4	-3.5	-2.0
Bone volume	2.6	4.5	9.3	-1.9	-0.3	2.4	-2.2	-3.1	-1.8
Bone: connectivity density	3.6	5.7	9.3	-2.1	-0.5	2.8	-2.6	-3.1	-2.3
Bone: cortical apparent density	0.1	0.2	0.5	-0.5	-0.7	0.4	-0.4	0.2	-0.1
Bone: cortical area	0.6	0.8	1.8	-1.2	-1.4	0.9	-1.0	-0.1	0.1
Bone: cortical porosity	0.5	0.5	1.3	-0.1	0.3	0.6	-0.6	-0.9	-1.1
Bone: cortical porosity	0.7	0.7	1.2	-0.7	-0.2	1.0	-1.0	-0.8	-1.1
Bone: cortical thickness	2.4	3.9	9.8	-2.7	-3.1	1.6	-1.8	0.8	0.3
Bone: cortical thickness	0.8	1.0	2.7	-1.1	-1.7	0.4	-0.5	1.2	0.4
Bone: cortical tissue density	0.2	0.2	0.6	-0.6	-0.8	0.4	-0.5	0.2	-0.0
Bone: elastic displacement	1.8	2.1	4.1	1.0	-0.1	-1.5	1.4	2.0	1.7
Bone: elastic work	0.7	0.9	2.7	-0.9	-1.6	0.5	-0.6	1.2	0.4
Bone: endosteal estimation	0.8	1.7	4.7	1.5	2.2	-0.7	0.9	-1.0	-1.0
Bone: endosteal perimeter	1.2	2.5	6.4	1.9	2.5	-0.6	0.9	-1.7	-0.9
Bone: final force	2.0	3.3	4.9	-2.1	-1.8	2.2	-2.2	-1.0	-1.2
Bone: final moment	1.8	2.9	4.3	-2.0	-1.7	2.0	-2.1	-1.0	-1.2
Bone: marrow area	0.8	1.8	4.9	1.5	2.2	-0.7	0.9	-0.9	-1.1
Bone: maximum diameter	0.1	0.1	0.2	-0.1	-0.4	0.3	-0.3	-0.5	0.5
Bone: maximum force	3.5	6.1	8.7	-2.4	-1.4	2.9	-2.9	-2.5	-2.4
Bone: maximum moment	3.0	5.2	7.5	-2.2	-1.3	2.7	-2.7	-2.3	-2.2
Bone: minimum diameter	1.0	1.8	4.3	1.0	2.1	-0.1	0.3	-1.6	-1.7
Bone: periosteal estimation	0.1	0.1	0.3	-0.0	0.3	0.1	-0.1	-0.6	-0.5
Bone: periosteal perimeter	0.3	0.4	1.4	-0.2	0.2	0.7	-0.6	-1.2	-0.6
Bone: post-yield work	5.4	7.4	18.8	-0.4	1.5	2.2	-1.8	-4.3	-3.9
Bone: stiffness	3.1	5.0	6.8	-2.1	-0.9	2.6	-2.5	-2.6	-2.1
Bone: tissue strength	0.2	0.2	0.6	-0.1	0.1	0.4	-0.3	-0.8	-0.3
Bone: trabecular number	1.9	3.0	7.8	-1.3	0.2	1.8	-1.6	-2.8	-1.6
Bone: trabecular spacing	0.6	0.7	1.5	1.1	0.2	-0.9	0.8	1.2	0.5
Bone: trabecular thickness	0.7	0.8	2.2	0.3	1.3	0.1	0.1	-1.5	-1.0
Bone: trabecular tissue density	3.3	4.6	7.0	2.6	1.7	-2.6	2.6	1.5	1.4
Breakpoint value in progressive ratio session	2.5	2.8	4.4	-1.8	-1.9	2.0	-2.1	-1.0	-0.8
Distance traveled before self-admin	0.3	0.3	0.5	-0.5	-0.5	0.7	-0.7	-0.5	-0.4
Distance traveled after self-admin	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4	-0.3	-0.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	-0.7	-0.5	0.0	-0.1	0.8	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.2	-0.2	0.1	-0.1	-0.3	0.5
Diff in mean of infusions in LGA sessions	0.4	0.4	1.0	-0.9	-1.0	0.5	-0.6	-0.2	0.4
Extinction: sum of active levers before priming	4.6	4.6	6.6	-2.2	-1.7	2.6	-2.6	-1.8	-1.9
Active lever presses in extinction session 6	1.8	1.7	3.9	-1.7	-2.0	1.1	-1.2	0.2	0.7
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.1	-0.0	-0.1	0.1	0.2	0.3
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.1	0.4	0.2
Time in closed arm before self-admin	0.1	0.1	0.5	0.1	0.2	0.2	-0.2	-0.7	-0.2
Time in closed arm after self-admin	0.0	0.0	0.2	-0.1	0.1	0.0	-0.0	-0.1	-0.5
Time in open arm before self-admin	0.5	0.5	1.2	0.7	0.5	-0.7	0.7	1.1	-0.1
Time in open arm after self-admin	0.4	0.5	0.9	0.4	0.0	-0.7	0.6	1.0	0.9
Sum of active levers in priming session hrs 5-6	1.5	1.4	4.1	-1.2	-2.0	0.6	-0.8	0.5	1.4
Time to tail flick, vehicle, before self-admin	0.7	0.7	0.9	-0.9	-0.2	0.9	-0.9	-0.8	-0.9
Time to tail flick, vehicle, after self-admin	1.6	1.7	2.6	-1.4	-0.7	1.5	-1.4	-0.9	-1.6
Time to tail flick, test, before self-admin	0.7	0.7	1.7	0.8	1.3	-0.2	0.3	-0.4	-1.2
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.0	0.1	0.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.7	-0.8	-0.3	0.9	-0.8	-0.7	-0.8
Delta time to tail flick, test, before/after SA	1.5	1.4	3.3	-1.3	-1.8	0.3	-0.4	0.7	1.6
Ambulatory time before self-admin	0.4	0.4	0.9	-0.6	-0.4	0.7	-0.7	-0.9	-0.1
Ambulatory time after self-admin	0.2	0.3	0.9	0.2	0.6	0.2	-0.1	-1.0	-0.4
Total heroin consumption	3.8	4.6	7.0	-2.4	-2.4	2.6	-2.6	-1.1	-1.1
Area under the delay curve	0.4	0.4	0.8	0.8	0.9	0.1	0.0	-0.7	-0.8
Delay disc. indifference point, 0s delay	0.7	0.7	1.8	1.1	1.3	-0.6	0.6	-0.0	-0.7
Delay disc. indifference point, 16s delay	0.9	0.9	1.8	1.3	1.4	-0.5	0.6	-1.2	-0.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.5	0.6	-0.2	0.3	0.0	-0.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	0.1	-0.4	0.4	0.1	0.3
Delay disc. indifference point, 4s delay	0.2	0.3	0.7	0.6	0.8	-0.2	0.3	-0.1	-0.6
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	0.7	0.6	-0.0	0.1	-0.1	-0.6
Delay discount exponential model param	0.3	0.3	0.5	-0.7	-0.7	-0.1	0.0	0.6	0.7
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.6	-0.7	-0.1	0.0	0.5	0.6
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	-0.3	-0.2	0.2	-0.2	-0.8	0.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.7	0.2	0.3	0.2	-0.2	-0.0	-0.8
Time >=10cm from walls, locomotor time 1	1.1	1.1	2.7	0.7	1.6	-0.0	0.2	-1.5	-1.0
Bouts of movement, locomotor time 1	1.0	1.1	1.4	-1.1	-1.1	1.2	-1.2	-1.2	-0.0
Total resting periods, locomotor time 1	0.9	1.0	1.8	-0.9	-0.8	1.1	-1.1	-1.4	-0.1
Rest time, locomotor task time 1	1.5	1.6	2.3	1.4	0.8	-1.5	1.5	0.9	1.3
Distance moved, locomotor task time 1	0.5	0.6	1.5	-0.4	0.2	0.8	-0.7	-0.6	-1.2
Vertical activity count, locomotor time 1	0.8	0.8	1.2	1.1	0.9	-1.1	1.1	0.4	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.3	0.2	0.1	-0.0	-0.4	-0.3
Bouts of movement, locomotor time 2	0.6	0.6	1.2	-1.1	-0.7	0.9	-0.9	-0.8	-0.2
Total resting periods, locomotor time 2	0.4	0.4	0.7	-0.9	-0.3	0.7	-0.7	-0.8	-0.2
Rest time, locomotor task time 2	1.9	2.1	3.2	1.7	1.6	-1.7	1.8	0.9	0.7
Distance moved, locomotor task time 2	0.7	0.8	1.5	-1.0	-1.2	1.1	-1.2	-0.1	-0.3
Vertical activity count, locomotor time 2	0.6	0.7	1.9	0.1	-0.8	-0.6	0.4	1.4	1.1
Weight adjusted by age	1.9	2.1	3.6	-1.9	-1.8	1.6	-1.7	-0.3	-0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.8	0.1	0.6	0.4	-0.3	-0.6	-0.9
Locomotion in novel chamber	3.7	4.6	6.7	2.6	2.2	-2.5	2.6	1.0	1.3
Locomotion in novel chamber post-restriction	2.2	2.6	4.0	1.9	1.7	-1.9	2.0	0.9	0.8
Progressive ratio	3.3	3.9	5.8	-1.6	-0.2	2.3	-2.1	-2.3	-2.4
Food seeking constrained by brief footshock	0.2	0.2	0.4	-0.6	-0.7	0.4	-0.4	0.4	-0.0
Seeking ratio, punishment vs. effort	2.6	3.2	5.4	1.6	0.3	-2.0	1.9	2.3	1.9
Run reversals in cocaine runway, females	1.3	1.3	4.3	-0.5	0.1	1.1	-1.1	-0.8	-2.1
Run reversals in cocaine runway, males	1.7	1.7	4.1	0.1	-0.7	-1.2	1.0	2.0	1.8
Latency to leave start box in cocaine runway	0.5	0.6	1.4	-0.0	0.6	0.5	-0.4	-1.2	-1.2
Latency to leave start box in cocaine runway, F	0.3	0.3	1.0	-0.0	0.4	0.4	-0.4	-0.8	-1.0
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	0.0	0.2	-0.2	-0.3	-0.3
Cd content in liver	1.5	1.7	2.8	1.1	0.8	-1.5	1.5	0.9	1.7
Co content in liver	2.5	3.0	6.7	1.2	0.4	-1.9	1.8	2.6	1.6
Cu content in liver	0.4	0.5	0.9	-0.5	-0.4	0.8	-0.8	-0.4	-0.9
Fe content in liver	0.1	0.1	0.3	-0.4	-0.5	0.2	-0.3	0.1	0.3
K content in liver	2.5	2.5	3.6	-1.1	-0.6	1.9	-1.8	-1.8	-1.8
Mg content in liver	2.0	2.1	4.5	-0.1	0.9	1.3	-1.1	-2.1	-2.1
Mn content in liver	2.5	2.9	4.0	-1.9	-1.5	2.0	-2.0	-1.7	-0.7
Na content in liver	0.5	0.5	1.7	-0.4	-1.3	0.7	-0.8	0.2	0.0
Rb content in liver	0.9	1.1	3.7	1.0	1.9	-0.7	0.9	-0.4	-0.7
Se content in liver	0.4	0.5	2.4	-0.1	0.4	0.5	-0.5	-1.6	-0.1
Sr content in liver	2.0	1.8	4.2	-1.8	-2.0	1.1	-1.3	0.1	0.7
Zn content in liver	1.2	1.3	1.8	-1.2	-0.9	1.3	-1.3	-1.0	-0.9