Hub : Traits

Cocaine response before conditioning

Cocaine response (4 x 10 mg/kg, ip), conditioned place preference, time in drug-paired compartment before any conditioning has occurred

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2014

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr8	108585012	109845634	1	1	7.96e-12	2.89e-02	1e+00	Klhdc8b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	18.84	1	1	100	0	1e+00	Klhdc8b
BMI without tail	27.06	1	1	100	0	1e+00	Klhdc8b
Body weight	20.7	1	1	100	0	1e+00	Klhdc8b
Heart weight	17.24	1	0	0	0	1e+00	Klhdc8b
Left kidney weight	27.97	1	1	100	0	1e+00	Klhdc8b
Right kidney weight	10.32	1	1	100	0	1e+00	Klhdc8b
Tail length	8.12	1	0	0	0	1e+00	Klhdc8b
Length with tail	9.26	1	1	100	0	1e+00	Klhdc8b
Length without tail	2.4	1	0	0	0	1e+00	Klhdc8b
Liver weight, left	13.45	1	0	0	0	1e+00	Klhdc8b
Liver weight, right	3.23	1	0	0	0	1e+00	Klhdc8b
Retroperitoneal fat weight	6.24	1	0	0	0	1e+00	Klhdc8b
Soleus weight	8.84	1	0	0	0	1e+00	Klhdc8b
Tibialis anterior weight	1.33	1	0	0	0	1e+00	Klhdc8b
Tibia length	10.96	1	1	100	0	1e+00	Klhdc8b
Number of licking bursts	24.53	1	1	100	0	1e+00	Klhdc8b
Food consumed during 24 hour testing period	9.01	1	0	0	0	1e+00	Klhdc8b
Times rat made contact with spout	5.33	1	0	0	0	1e+00	Klhdc8b
Mean time between licks in bursts	5.14	1	0	0	0	1e+00	Klhdc8b
Mean num. licks in bursts	11.71	1	0	0	0	1e+00	Klhdc8b
Water consumed over 24 hours	8.34	1	0	0	0	1e+00	Klhdc8b
Patch foraging indifference point 0 sec	8.18	1	0	0	0	1e+00	Klhdc8b
Patch foraging indifference point AUC	4.75	1	0	0	0	1e+00	Klhdc8b
Indifference point function ln k	36.38	1	1	100	0	1e+00	Klhdc8b
Indifference point function log k	36.38	1	1	100	0	1e+00	Klhdc8b
Patch foraging total patch changes 0 sec	8.89	1	0	0	0	1e+00	Klhdc8b
Patch foraging total patch changes 18 sec	5.31	1	0	0	0	1e+00	Klhdc8b
Patch foraging total patch changes 24 sec	6.54	1	0	0	0	1e+00	Klhdc8b
Patch foraging time to switch 0 sec	6.73	1	0	0	0	1e+00	Klhdc8b
Patch foraging water rate 6 sec	2.67	1	0	0	0	1e+00	Klhdc8b
Locomotor activity	57.78	1	1	100	0	1e+00	Klhdc8b
Locomotor testing distance	64.52	1	1	100	0	1e+00	Klhdc8b
Locomotor testing rearing	3.38	1	0	0	0	1e+00	Klhdc8b
Light reinforcement 2	7.12	1	0	0	0	1e+00	Klhdc8b
Reaction time number correct	18.64	1	1	100	0	1e+00	Klhdc8b
Reaction time num false alarms	5.75	1	0	0	0	1e+00	Klhdc8b
Reaction time num false alarms AUC	6.59	1	0	0	0	1e+00	Klhdc8b
Reaction time trials correct on left	18.64	1	1	100	0	1e+00	Klhdc8b
Reaction time trials on left	19.51	1	1	100	0	1e+00	Klhdc8b
Reaction time mean	3.45	1	0	0	0	1e+00	Klhdc8b
Reaction time mean AUC	9.44	1	0	0	0	1e+00	Klhdc8b
Median of all reaction times	10.54	1	0	0	0	1e+00	Klhdc8b
Reaction time omissions	23.75	1	1	100	0	1e+00	Klhdc8b
Reaction time false alarm rate	20.24	1	1	100	0	1e+00	Klhdc8b
Reaction time premature initiations	5.21	1	0	0	0	1e+00	Klhdc8b
Std. dev. reaction times	3.82	1	0	0	0	1e+00	Klhdc8b
Reaction time trials completed	19.51	1	1	100	0	1e+00	Klhdc8b
Reaction time trials AUC	20.65	1	1	100	0	1e+00	Klhdc8b
Social response proportion	4.26	1	0	0	0	1e+00	Klhdc8b
Conditioned locomotion	28.4	1	1	100	0	1e+00	Klhdc8b
Cocaine response after cond. not corrected	16.6	1	0	0	0	1e+00	Klhdc8b
Saline control response	4.21	1	0	0	0	1e+00	Klhdc8b
Condit. Reinf. inactive responses	3.79	1	0	0	0	1e+00	Klhdc8b
Pavlov. Cond. magazine entry latency	5.33	1	0	0	0	1e+00	Klhdc8b
Pavlov. Cond. magazine entry number	30	1	1	100	0	1e+00	Klhdc8b
Pavlov. Cond. intertrial magazine entries	7.56	1	0	0	0	1e+00	Klhdc8b
Pavlov. Cond. response bias	5.18	1	0	0	0	1e+00	Klhdc8b
Conditioned reinforcement - inactives	16.77	1	0	0	0	1e+00	Klhdc8b
Conditioned locomotion	4.19	1	0	0	0	1e+00	Klhdc8b
Intermitt. access day 1 inactive lever presses	13.69	1	0	0	0	1e+00	Klhdc8b
Intermitt. access day 15 inactive lever presses	30.78	1	1	100	0	1e+00	Klhdc8b
Intermittent access day 1 total infusions	7.02	1	0	0	0	1e+00	Klhdc8b
Intermittent access day 15 total infusions	14.21	1	0	0	0	1e+00	Klhdc8b
Intermittent access terminal intake (last 3 days)	24.03	1	0	0	0	1e+00	Klhdc8b
Intermittent access total infusions	15.45	1	0	0	0	1e+00	Klhdc8b
Intermittent access day 1 locomotion	11.5	1	0	0	0	1e+00	Klhdc8b
Intermittent access total locomotion	3.46	1	0	0	0	1e+00	Klhdc8b
Intermittent access standard deviation	16.8	1	0	0	0	1e+00	Klhdc8b
Cocaine induced anxiety	13.65	1	0	0	0	1e+00	Klhdc8b
Lifetime Intake	9.49	1	0	0	0	1e+00	Klhdc8b
Progressive ratio test 1 inactive lever presses	16.55	1	0	0	0	1e+00	Klhdc8b
Progressive ratio test 2 active lever presses	4.8	1	0	0	0	1e+00	Klhdc8b
Progressive ratio test 2 inactive lever presses	10.83	1	0	0	0	1e+00	Klhdc8b
Total sessions with >9 infusions	16	1	0	0	0	1e+00	Klhdc8b
Short access day 1 total inactive lever presses	13.04	1	0	0	0	1e+00	Klhdc8b
Short access day 10 total inactive lever presses	101.65	1	1	100	0	1e+00	Klhdc8b
Short access day 10 total infusions	13.17	1	0	0	0	1e+00	Klhdc8b
Short access total infusions	5.11	1	0	0	0	1e+00	Klhdc8b
Short access day 1 locomotion	11.78	1	0	0	0	1e+00	Klhdc8b
Short access total locomotion	3.87	1	0	0	0	1e+00	Klhdc8b
One hour access (0.3 mA shock)	13.43	1	0	0	0	1e+00	Klhdc8b
One hour access (shock baseline)	8.36	1	0	0	0	1e+00	Klhdc8b
Context. condit. distance diff. score	3.61	1	0	0	0	1e+00	Klhdc8b
Locomotion distance, session 1	23.98	1	1	100	0	1e+00	Klhdc8b
Locomotion velocity, session 2	10	1	0	0	0	1e+00	Klhdc8b
Locomotion distance, session 2	33.15	1	1	100	0	1e+00	Klhdc8b
Locomotion velocity, session 3	17.14	1	0	0	0	1e+00	Klhdc8b
Locomotion distance, session 3	14.51	1	0	0	0	1e+00	Klhdc8b
Stereotopy head waving duration, day 3	6.96	1	0	0	0	1e+00	Klhdc8b
Locomotion velocity, session 8	9.36	1	0	0	0	1e+00	Klhdc8b
Locomotion distance, session 8	52.78	1	1	100	0	1e+00	Klhdc8b
Degree of sensitization distance	24.75	1	0	0	0	1e+00	Klhdc8b
Condit. Reinf. active minus inactive responses	35.59	1	1	100	0	1e+00	Klhdc8b
Condit. Reinf. active-inactive response ratio	25.6	1	1	100	0	1e+00	Klhdc8b
Condit. Reinf. active responses	18.23	1	0	0	0	1e+00	Klhdc8b
Incentive salience index mean	26.23	1	1	100	0	1e+00	Klhdc8b
Condit. Reinf. lever presses	10.81	1	0	0	0	1e+00	Klhdc8b
Time in familiar zone, hab. session 1	63.49	1	1	100	0	1e+00	Klhdc8b
Time in novel zone, hab. session 1	13.1	1	0	0	0	1e+00	Klhdc8b
Total zone transitions, hab. session 1	37.38	1	1	100	0	1e+00	Klhdc8b
Total locomotion distance, hab. session 1	10.76	1	0	0	0	1e+00	Klhdc8b
Locomotion velocity, hab. session 1	10.22	1	0	0	0	1e+00	Klhdc8b
Time in familiar zone, hab. session 2	27.1	1	1	100	0	1e+00	Klhdc8b
Time in novel zone, hab. session 2	10.13	1	0	0	0	1e+00	Klhdc8b
Total zone transitions, hab. session 2	69.58	1	1	100	0	1e+00	Klhdc8b
Total locomotion distance, hab. session 2	19.2	1	0	0	0	1e+00	Klhdc8b
Locomotion velocity, hab. session 2	21.15	1	1	100	0	1e+00	Klhdc8b
Novel to familiar place preference ratio	22.33	1	0	0	0	1e+00	Klhdc8b
Novelty place preference	20.99	1	0	0	0	1e+00	Klhdc8b
Time in novel zone, NPP test	17.06	1	0	0	0	1e+00	Klhdc8b
Total zone transitions, NPP test	106.24	1	1	100	0	1e+00	Klhdc8b
Total locomotion distance, NPP test	47.64	1	1	100	0	1e+00	Klhdc8b
Locomotion velocity, NPP test	51.12	1	1	100	0	1e+00	Klhdc8b
Pavlov. Cond. change in total contacts	69.48	1	1	100	0	1e+00	Klhdc8b
Pavlov. Cond. index score	14.07	1	0	0	0	1e+00	Klhdc8b
Pavlov. Cond. latency score	8.82	1	0	0	0	1e+00	Klhdc8b
Pavlov. Cond. lever contacts	4.86	1	0	0	0	1e+00	Klhdc8b
Pavlov. Cond. magazine entry number	12.23	1	0	0	0	1e+00	Klhdc8b
Pavlov. Cond. lever-magazine prob. diff.	14.82	1	0	0	0	1e+00	Klhdc8b
Pavlov. Cond. response bias	10.49	1	0	0	0	1e+00	Klhdc8b
Bone: cortical porosity	6.2	1	0	0	0	1e+00	Klhdc8b
Bone: endosteal estimation	4	1	0	0	0	1e+00	Klhdc8b
Bone: final force	4.4	1	0	0	0	1e+00	Klhdc8b
Bone: marrow area	3.15	1	0	0	0	1e+00	Klhdc8b
Bone: maximum diameter	3.26	1	0	0	0	1e+00	Klhdc8b
Bone: maximum force	7.19	1	0	0	0	1e+00	Klhdc8b
Bone: maximum moment	3.52	1	0	0	0	1e+00	Klhdc8b
Bone: periosteal estimation	3.04	1	0	0	0	1e+00	Klhdc8b
Bone: periosteal perimeter	2.96	1	0	0	0	1e+00	Klhdc8b
Bone: stiffness	13.41	1	0	0	0	1e+00	Klhdc8b
Bone: trabecular tissue density	3.12	1	0	0	0	1e+00	Klhdc8b
Delta time in closed arm before/after self-admin	12.84	1	0	0	0	1e+00	Klhdc8b
Extinction: sum of active levers before priming	5.93	1	0	0	0	1e+00	Klhdc8b
Active lever presses in extinction session 6	7.23	1	0	0	0	1e+00	Klhdc8b
Time in closed arm after self-admin	5.85	1	0	0	0	1e+00	Klhdc8b
Sum of active levers in priming session hrs 5-6	4.91	1	0	0	0	1e+00	Klhdc8b
Time to tail flick, vehicle, after self-admin	37.57	1	1	100	0	1e+00	Klhdc8b
Delta time to tail flick, vehicle, before/after SA	14.47	1	0	0	0	1e+00	Klhdc8b
Ambulatory time after self-admin	6.07	1	0	0	0	1e+00	Klhdc8b
Total heroin consumption	18.89	1	0	0	0	1e+00	Klhdc8b
Area under the delay curve	4.87	1	0	0	0	1e+00	Klhdc8b
Delay disc. indifference point, 0s delay	28.7	1	1	100	0	1e+00	Klhdc8b
Delay disc. indifference point, 16s delay	13.12	1	0	0	0	1e+00	Klhdc8b
Delay disc. indifference point, 4s delay	41.82	1	1	100	0	1e+00	Klhdc8b
Delay disc. indifference point, 8s delay	5.59	1	0	0	0	1e+00	Klhdc8b
Delay discount hyperbolic model param	5.02	1	0	0	0	1e+00	Klhdc8b
Fecal boli incidents, locomotor time 1	16.98	1	0	0	0	1e+00	Klhdc8b
Change in fecal boli incidents, locomotor task	4.32	1	0	0	0	1e+00	Klhdc8b
Time >=10cm from walls, locomotor time 1	7.65	1	0	0	0	1e+00	Klhdc8b
Bouts of movement, locomotor time 1	4.44	1	0	0	0	1e+00	Klhdc8b
Total resting periods, locomotor time 1	4.04	1	0	0	0	1e+00	Klhdc8b
Rest time, locomotor task time 1	22.55	1	0	0	0	1e+00	Klhdc8b
Distance moved, locomotor task time 1	31.01	1	1	100	0	1e+00	Klhdc8b
Vertical activity count, locomotor time 1	49.01	1	1	100	0	1e+00	Klhdc8b
Time >=10cm from walls, locomotor time 2	4.57	1	0	0	0	1e+00	Klhdc8b
Bouts of movement, locomotor time 2	19.85	1	0	0	0	1e+00	Klhdc8b
Total resting periods, locomotor time 2	20.22	1	0	0	0	1e+00	Klhdc8b
Rest time, locomotor task time 2	25.34	1	1	100	0	1e+00	Klhdc8b
Distance moved, locomotor task time 2	42.39	1	1	100	0	1e+00	Klhdc8b
Vertical activity count, locomotor time 2	54.92	1	1	100	0	1e+00	Klhdc8b
Weight adjusted by age	30.32	1	1	100	0	1e+00	Klhdc8b
Locomotion in novel chamber	3.85	1	0	0	0	1e+00	Klhdc8b
Progressive ratio	7.25	1	0	0	0	1e+00	Klhdc8b
Food seeking constrained by brief footshock	12.71	1	0	0	0	1e+00	Klhdc8b
Seeking ratio, punishment vs. effort	4.64	1	0	0	0	1e+00	Klhdc8b
Run reversals in cocaine runway, females	6.51	1	0	0	0	1e+00	Klhdc8b
Cd content in liver	20.17	1	0	0	0	1e+00	Klhdc8b
Fe content in liver	40.39	1	1	100	0	1e+00	Klhdc8b
K content in liver	12.22	1	0	0	0	1e+00	Klhdc8b
Mg content in liver	15.79	1	0	0	0	1e+00	Klhdc8b
Mn content in liver	5.99	1	0	0	0	1e+00	Klhdc8b
Na content in liver	16.36	1	0	0	0	1e+00	Klhdc8b
Rb content in liver	51.88	1	1	100	0	1e+00	Klhdc8b
Se content in liver	8.45	1	0	0	0	1e+00	Klhdc8b
Sr content in liver	22.41	1	0	0	0	1e+00	Klhdc8b
Zn content in liver	9.95	1	0	0	0	1e+00	Klhdc8b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.25
Adipose	alternative TSS	0	0	1.2
Adipose	gene expression	0	0	1.16
Adipose	isoform ratio	0	0	1.21
Adipose	intron excision ratio	0	0	1.39
Adipose	mRNA stability	0	0	1.17
BLA	alternative polyA	0	0	1.3
BLA	alternative TSS	0	0	1.15
BLA	gene expression	0	0	1.18
BLA	isoform ratio	0	0	1.19
BLA	intron excision ratio	0	0	1.33
BLA	mRNA stability	0	0	1.17
Brain	alternative polyA	0	0	1.29
Brain	alternative TSS	0	0	1.17
Brain	gene expression	0	0	1.13
Brain	isoform ratio	0	0	1.15
Brain	intron excision ratio	0	0	1.27
Brain	mRNA stability	0	0	1.14
Eye	alternative polyA	0	0	1.4
Eye	alternative TSS	0	0	0.94
Eye	gene expression	0	0	1.16
Eye	isoform ratio	0	0	1.1
Eye	intron excision ratio	0	0	1.53
Eye	mRNA stability	0	0	1.28
IL	alternative polyA	0	0	1.31
IL	alternative TSS	0	0	1.18
IL	gene expression	0	0	1.18
IL	isoform ratio	0	0	1.13
IL	intron excision ratio	0	0	1.4
IL	mRNA stability	0	0	1.14
LHb	alternative polyA	0	0	1.33
LHb	alternative TSS	0	0	1.19
LHb	gene expression	0	0	1.19
LHb	isoform ratio	0	0	1.14
LHb	intron excision ratio	0	0	1.55
LHb	mRNA stability	0	0	1.2
Liver	alternative polyA	0	0	1.28
Liver	alternative TSS	0	0	1.19
Liver	gene expression	1	0	1.19
Liver	isoform ratio	0	0	1.23
Liver	intron excision ratio	0	0	1.2
Liver	mRNA stability	0	0	1.17
NAcc	alternative polyA	0	0	1.24
NAcc	alternative TSS	0	0	1.24
NAcc	gene expression	0	0	1.16
NAcc	isoform ratio	0	0	1.16
NAcc	intron excision ratio	0	0	1.31
NAcc	mRNA stability	0	0	1.2
OFC	alternative polyA	0	0	1.31
OFC	alternative TSS	0	0	1.21
OFC	gene expression	0	0	1.14
OFC	isoform ratio	0	0	1.22
OFC	intron excision ratio	0	0	1.51
OFC	mRNA stability	0	0	1.21
PL	alternative polyA	0	0	1.27
PL	alternative TSS	0	0	1.21
PL	gene expression	0	0	1.16
PL	isoform ratio	0	0	1.19
PL	intron excision ratio	0	0	1.3
PL	mRNA stability	0	0	1.16
pVTA	alternative polyA	0	0	1.41
pVTA	alternative TSS	0	0	1.27
pVTA	gene expression	0	0	1.2
pVTA	isoform ratio	0	0	1.24
pVTA	intron excision ratio	0	0	1.39
pVTA	mRNA stability	0	0	1.15
RMTg	alternative polyA	0	0	1.37
RMTg	alternative TSS	0	0	1.21
RMTg	gene expression	0	0	1.22
RMTg	isoform ratio	0	0	1.3
RMTg	intron excision ratio	0	0	1.15
RMTg	mRNA stability	0	0	1.12