Hub : Traits

Reaction time num false alarms AUC

AUC across the 6 time epochs were fit for males and females

Tags: Behavior · Reaction time

Project: p50_david_dietz

5 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 7 16845355 16970279 1 1 6.1e-41 NaN NA NA NA
2 10 10829424 12227767 1 1 9.4e-08 4.6e-07 0.73 100 Slx4
3 10 61058947 62452613 1 1 8.0e-08 2.1e-03 1.00 100 Blmh

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 106.7 1 1 33 0.00 1.00000 NA
Body weight 4.9 3 1 33 0.83 0.16751 Blmh Slx4 NA
Epididymis fat weight 87.6 1 1 33 0.00 1.00000 NA
Glucose 6.0 2 0 0 0.00 1.00000 Blmh NA
Heart weight 11.4 1 0 0 0.00 1.00000 NA
Left kidney weight 20.0 2 1 33 0.98 0.02028 Slx4 NA
Right kidney weight 41.9 1 1 33 0.00 1.00000 NA
Tail length 31.0 2 1 33 0.99 0.01245 Slx4 NA
Length with tail 5.2 2 1 33 0.80 0.20023 Slx4 NA
Length without tail 71.1 1 1 33 0.00 1.00000 NA
Liver weight, left 23.6 1 1 33 0.00 1.00000 NA
Liver weight, right 9.6 1 0 0 0.00 1.00000 NA
Parametrial fat weight 11.1 2 1 33 0.00 1.00000 Blmh NA
Retroperitoneal fat weight 4.2 2 0 0 0.00 1.00000 Slx4 NA
Intraocular pressure 19.0 1 1 33 0.00 1.00000 NA
Extensor digitorum longus weight 25.8 1 1 33 0.00 1.00000 NA
Soleus weight 13.7 1 1 33 0.00 1.00000 NA
Tibialis anterior weight 59.9 1 1 33 0.00 1.00000 NA
Tibia length 5.3 1 0 0 0.00 1.00000 NA
Number of licking bursts 155.0 1 1 33 0.00 1.00000 NA
Food consumed during 24 hour testing period 12.1 2 0 0 0.00 1.00000 Slx4 NA
Times rat made contact with spout 75.1 1 1 33 0.00 1.00000 NA
Mean time between licks in bursts 54.9 1 1 33 0.00 1.00000 NA
Mean num. licks in bursts 164.2 1 1 33 0.00 1.00000 NA
Std. dev. time between licks in bursts 177.7 1 1 33 0.00 1.00000 NA
Water consumed over 24 hours 5.7 1 0 0 0.00 1.00000 NA
Indifference point 0 sec 13.9 2 1 33 0.00 1.00000 Blmh NA
Indifference point AUC 31.0 2 1 33 0.00 1.00000 Blmh NA
Delay discounting total patch changes 0 sec 17.7 1 1 33 0.00 1.00000 NA
Delay discounting total patch changes 12 sec 102.7 1 1 33 0.00 1.00000 NA
Delay discounting total patch changes 18 sec 175.3 1 1 33 0.00 1.00000 NA
Delay discounting total patch changes 24 sec 28.3 1 1 33 0.00 1.00000 NA
Delay discounting total patch changes 6 sec 67.6 2 1 33 0.00 1.00000 Blmh NA
Delay discounting time to switch 0 sec 6.3 1 0 0 0.00 1.00000 Blmh
Delay discounting water rate 0 sec 7.2 2 0 0 0.00 1.00000 Blmh NA
Delay discounting water rate 12 sec 20.1 2 1 33 0.00 1.00000 Blmh NA
Delay discounting water rate 18 sec 10.5 1 0 0 0.00 1.00000 NA
Delay discounting water rate 24 sec 62.7 1 1 33 0.00 1.00000 NA
Delay discounting water rate 6 sec 44.2 1 1 33 0.00 1.00000 NA
Locomotor testing distance 11.5 1 0 0 0.00 1.00000 NA
Locomotor testing rearing 16.8 1 1 33 0.00 1.00000 NA
Light reinforcement 1 54.8 1 1 33 0.00 1.00000 NA
Reaction time number correct 9.4 1 0 0 0.00 1.00000 NA
Reaction time num false alarms 35.5 3 3 100 0.99 0.00043 Blmh Slx4 NA
Reaction time trials correct on left 9.4 1 0 0 0.00 1.00000 NA
Reaction time trials on left 10.3 1 0 0 0.00 1.00000 NA
Reaction time mean 41.3 1 1 33 0.00 1.00000 NA
Reaction time mean AUC 58.0 1 1 33 0.00 1.00000 NA
Median of all reaction times 51.2 1 1 33 0.00 1.00000 NA
Reaction time false alarm rate 32.1 3 1 33 1.00 0.00037 Blmh Slx4 NA
Reaction time premature initiation rate 32.1 1 1 33 0.00 1.00000 NA
Reaction time premature initiations 34.3 1 1 33 0.00 1.00000 NA
Std. dev. reaction times 17.4 1 1 33 0.00 1.00000 NA
Reaction time trials completed 10.3 1 0 0 0.00 1.00000 NA
Reaction time trials AUC 15.6 1 0 0 0.00 1.00000 NA
Social responses 74.3 1 1 33 0.00 1.00000 NA
Social time 7.8 1 0 0 0.00 1.00000 NA
Cocaine response after cond. corrected 78.0 1 1 33 0.00 1.00000 NA
Cocaine response after cond. not corrected 71.3 2 1 33 0.00 1.00000 Blmh NA
Cocaine response before conditioning 17.4 1 1 33 0.00 1.00000 NA
Saline control response 30.3 1 1 33 0.00 1.00000 NA
Condit. Reinf. active minus inactive responses 29.4 1 1 33 0.00 1.00000 NA
Condit. Reinf. active-inactive response ratio 40.7 1 1 33 0.00 1.00000 NA
Condit. Reinf. active responses 11.1 1 0 0 0.00 1.00000 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0.00 1.00000 NA
Pavlov. Cond. lever latency 36.3 1 1 33 0.00 1.00000 NA
Pavlov. Cond. magazine entry latency 104.9 1 1 33 0.00 1.00000 NA
Pavlov. Cond. change in total contacts 130.1 1 1 33 0.00 1.00000 NA
Pavlov. Cond. index score 62.2 1 1 33 0.00 1.00000 NA
Pavlov. Cond. latency score 67.1 1 1 33 0.00 1.00000 NA
Pavlov. Cond. lever contacts 17.2 1 1 33 0.00 1.00000 NA
Pavlov. Cond. magazine entry number 150.0 1 1 33 0.00 1.00000 NA
Pavlov. Cond. intertrial magazine entries 63.9 1 1 33 0.00 1.00000 NA
Pavlov. Cond. lever-magazine prob. diff. 55.1 1 1 33 0.00 1.00000 NA
Pavlov. Cond. response bias 30.8 1 1 33 0.00 1.00000 NA
Conditioned reinforcement - actives 13.0 1 0 0 0.00 1.00000 NA
Conditioned locomotion 9.9 1 0 0 0.00 1.00000 NA
Intermittent access intake day 1-15 change 44.5 2 1 33 0.00 1.00000 Blmh NA
Intermittent access intake escalation 82.5 1 1 33 0.00 1.00000 NA
Intermittent access intake escalation 2 24.7 1 1 33 0.00 1.00000 NA
Intermitt. access day 1 inactive lever presses 19.4 1 1 33 0.00 1.00000 NA
Intermitt. access escalation Index 9.2 1 0 0 0.00 1.00000 NA
Intermittent access day 1 total infusions 32.7 1 1 33 0.00 1.00000 NA
Intermittent access day 1 locomotion 18.4 1 1 33 0.00 1.00000 NA
Post-drug Anxiety 13.7 1 0 0 0.00 1.00000 NA
Baseline Anxiety 15.1 1 0 0 0.00 1.00000 Blmh
Progressive ratio test 1 active lever presses 11.8 1 0 0 0.00 1.00000 NA
Progressive ratio test 1 breakpoint 10.4 1 0 0 0.00 1.00000 NA
Progressive ratio test 1 inactive lever presses 10.8 1 0 0 0.00 1.00000 NA
Progressive ratio test 2 active lever presses 12.2 1 0 0 0.00 1.00000 NA
Progressive ratio test 2 breakpoint 38.7 1 1 33 0.00 1.00000 NA
Short access day 10 total inactive lever presses 12.2 1 0 0 0.00 1.00000 NA
Short access day 1 total infusions 8.2 1 0 0 0.00 1.00000 Blmh
Short access day 10 total infusions 24.0 1 1 33 0.00 1.00000 NA
Short access day 1 locomotion 17.2 1 0 0 0.00 1.00000 NA
Compulsive drug intake 28.2 1 1 33 0.00 1.00000 NA
One hour access (0.3 mA shock) 10.4 1 0 0 0.00 1.00000 NA
Context. condit. distance diff. score 149.8 1 1 33 0.00 1.00000 NA
Locomotion velocity, session 1 117.8 1 1 33 0.00 1.00000 NA
Locomotion distance, session 1 252.3 2 1 33 0.00 1.00000 Blmh NA
Locomotion velocity, session 2 82.2 1 1 33 0.00 1.00000 NA
Locomotion distance, session 2 776.0 1 1 33 0.00 1.00000 NA
Locomotion velocity, session 3 116.1 1 1 33 0.00 1.00000 NA
Locomotion distance, session 3 82.4 1 1 33 0.00 1.00000 NA
Stereotopy head waving bouts, day 3 8.8 1 0 0 0.00 1.00000 NA
Stereotopy head waving duration, day 3 25.6 1 1 33 0.00 1.00000 NA
Locomotion velocity, session 7 66.3 1 1 33 0.00 1.00000 NA
Locomotion distance, session 7 21.3 1 1 33 0.00 1.00000 NA
Stereotopy head waving bouts, day 7 42.6 1 1 33 0.00 1.00000 NA
Stereotopy head waving duration, day 7 63.4 1 1 33 0.00 1.00000 NA
Locomotion distance, session 8 102.8 1 1 33 0.00 1.00000 NA
Degree of sensitization distance 140.6 1 1 33 0.00 1.00000 NA
Degree of sensitization stereotypy 22.9 1 1 33 0.00 1.00000 NA
Condit. Reinf. active-inactive response ratio 65.1 1 1 33 0.00 1.00000 NA
Condit. Reinf. active responses 20.0 1 0 0 0.00 1.00000 NA
Condit. Reinf. inactive responses 17.2 1 0 0 0.00 1.00000 NA
Incentive salience index mean 10.7 2 0 0 0.00 1.00000 Blmh NA
Condit. Reinf. lever presses 20.3 1 1 33 0.00 1.00000 NA
Time in familiar zone, hab. session 1 16.4 1 0 0 0.00 1.00000 NA
Time in novel zone, hab. session 1 12.9 1 0 0 0.00 1.00000 NA
Total zone transitions, hab. session 1 279.8 2 1 33 0.00 1.00000 Blmh NA
Total locomotion distance, hab. session 1 171.4 1 1 33 0.00 1.00000 NA
Locomotion velocity, hab. session 1 218.6 1 1 33 0.00 1.00000 NA
Time in familiar zone, hab. session 2 28.0 1 1 33 0.00 1.00000 NA
Time in novel zone, hab. session 2 34.1 1 1 33 0.00 1.00000 NA
Total zone transitions, hab. session 2 173.5 2 1 33 0.00 1.00000 Blmh NA
Total locomotion distance, hab. session 2 133.1 1 1 33 0.00 1.00000 NA
Locomotion velocity, hab. session 2 139.4 1 1 33 0.00 1.00000 NA
Total zone transitions, NPP test 154.7 2 1 33 0.00 1.00000 Blmh NA
Total locomotion distance, NPP test 112.5 2 1 33 0.00 1.00000 Blmh NA
Locomotion velocity, NPP test 133.5 2 1 33 0.00 1.00000 Blmh NA
Pavlov. Cond. lever latency 7.6 2 0 0 0.00 1.00000 Blmh NA
Pavlov. Cond. magazine entry latency 56.4 1 1 33 0.00 1.00000 NA
Pavlov. Cond. change in total contacts 40.1 1 1 33 0.00 1.00000 NA
Pavlov. Cond. index score 28.9 1 1 33 0.00 1.00000 NA
Pavlov. Cond. latency score 16.6 1 0 0 0.00 1.00000 NA
Pavlov. Cond. lever contacts 13.3 1 0 0 0.00 1.00000 NA
Pavlov. Cond. magazine entry number 34.9 1 1 33 0.00 1.00000 NA
Pavlov. Cond. lever-magazine prob. diff. 50.5 1 1 33 0.00 1.00000 NA
Pavlov. Cond. response bias 29.4 1 1 33 0.00 1.00000 NA
Bone: apparent density 18.6 1 1 33 0.00 1.00000 NA
Bone surface 28.9 1 1 33 0.00 1.00000 NA
Bone volume 23.0 2 1 33 0.00 1.00000 Blmh NA
Bone: connectivity density 8.5 1 0 0 0.00 1.00000 NA
Bone: cortical porosity 58.8 2 1 33 -0.82 0.17586 Slx4 NA
Bone: cortical porosity 49.2 2 1 33 -0.83 0.17291 Slx4 NA
Bone: cortical thickness 8.8 1 0 0 0.00 1.00000 NA
Bone: cortical thickness 17.9 1 0 0 0.00 1.00000 NA
Bone: elastic displacement 14.4 2 1 33 0.00 1.00000 Blmh NA
Bone: elastic work 13.5 1 0 0 0.00 1.00000 Blmh
Bone: endosteal estimation 12.7 1 1 33 0.00 1.00000 NA
Bone: final force 39.5 1 1 33 0.00 1.00000 NA
Bone: final moment 31.9 1 1 33 0.00 1.00000 NA
Bone: marrow area 10.6 1 1 33 0.00 1.00000 NA
Bone: maximum force 42.0 1 1 33 0.00 1.00000 NA
Bone: maximum moment 29.5 1 1 33 0.00 1.00000 NA
Bone: minimum diameter 57.3 1 1 33 0.00 1.00000 NA
Bone: periosteal estimation 7.8 1 0 0 0.00 1.00000 NA
Bone: periosteal perimeter 6.4 1 0 0 0.00 1.00000 NA
Bone: post-yield work 82.8 1 1 33 0.00 1.00000 NA
Bone: stiffness 61.7 2 1 33 0.00 1.00000 Blmh NA
Bone: tissue strength 81.0 1 1 33 0.00 1.00000 NA
Bone: trabecular number 39.4 1 1 33 0.00 1.00000 NA
Bone: trabecular spacing 5.7 1 0 0 0.00 1.00000 NA
Bone: trabecular thickness 10.4 1 0 0 0.00 1.00000 NA
Bone: trabecular tissue density 43.1 1 1 33 0.00 1.00000 NA
Distance traveled before self-admin 9.8 1 0 0 0.00 1.00000 NA
Delta time in open arm before/after self-admin 40.2 1 1 33 0.00 1.00000 NA
Extinction: sum of active levers before priming 12.2 1 0 0 0.00 1.00000 NA
Active lever presses in extinction session 6 9.2 1 0 0 0.00 1.00000 NA
Delta distance traveled before/after self-admin 9.0 2 0 0 0.00 1.00000 Blmh NA
Delta ambulatory time before/after self-admin 6.4 1 0 0 0.00 1.00000 Blmh
Time in closed arm before self-admin 50.0 1 1 33 0.00 1.00000 NA
Time in closed arm after self-admin 25.8 1 1 33 0.00 1.00000 NA
Time in open arm after self-admin 31.3 1 1 33 0.00 1.00000 NA
Time to tail flick, vehicle, after self-admin 7.4 1 0 0 0.00 1.00000 Slx4
Delta time to tail flick, vehicle, before/after SA 7.5 1 0 0 0.00 1.00000 NA
Delta time to tail flick, test, before/after SA 20.0 1 0 0 0.00 1.00000 NA
Total heroin consumption 6.4 1 0 0 0.00 1.00000 Blmh
Area under the delay curve 7.2 1 0 0 0.00 1.00000 Blmh
Delay disc. indifference point, 0s delay 7.6 1 0 0 0.00 1.00000 Blmh
Delay disc. indifference point, 2s delay 7.0 1 0 0 0.00 1.00000 Blmh
Fecal boli incidents, locomotor time 1 11.5 2 0 0 0.00 1.00000 Blmh NA
Change in fecal boli incidents, locomotor task 8.8 1 0 0 0.00 1.00000 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0 0.00 1.00000 NA
Bouts of movement, locomotor time 1 6.2 1 0 0 0.00 1.00000 Slx4
Distance moved, locomotor task time 1 6.9 1 0 0 0.00 1.00000 Blmh
Time >=10cm from walls, locomotor time 2 19.4 1 1 33 0.00 1.00000 NA
Rest time, locomotor task time 2 8.8 1 0 0 0.00 1.00000 NA
Distance moved, locomotor task time 2 9.6 2 0 0 0.00 1.00000 Blmh NA
Weight adjusted by age 16.7 1 1 33 0.00 1.00000 NA
Locomotion in novel chamber 10.2 1 0 0 0.00 1.00000 NA
Food seeking constrained by brief footshock 6.2 1 0 0 0.00 1.00000 Blmh
Run reversals in cocaine runway, males 25.4 1 1 33 0.00 1.00000 NA
Latency to leave start box in cocaine runway 18.8 1 0 0 0.00 1.00000 NA
Cd content in liver 140.5 1 1 33 0.00 1.00000 NA
Co content in liver 83.2 1 1 33 0.00 1.00000 NA
Fe content in liver 10.3 1 0 0 0.00 1.00000 NA
K content in liver 62.6 1 1 33 0.00 1.00000 NA
Mn content in liver 130.2 1 1 33 0.00 1.00000 NA
Rb content in liver 18.6 1 1 33 0.00 1.00000 NA
Se content in liver 47.0 1 1 33 0.00 1.00000 NA
Zn content in liver 46.0 1 1 33 0.00 1.00000 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 0 0.000 1.4
Adipose gene expression 1 0.012 1.4
Adipose isoform ratio 0 0.000 1.4
Adipose intron excision ratio 0 0.000 1.4
Adipose mRNA stability 1 0.029 1.4
BLA alternative polyA 0 0.000 1.4
BLA alternative TSS 0 0.000 1.5
BLA gene expression 0 0.000 1.4
BLA isoform ratio 0 0.000 1.4
BLA intron excision ratio 0 0.000 1.4
BLA mRNA stability 0 0.000 1.4
Brain alternative polyA 0 0.000 1.4
Brain alternative TSS 0 0.000 1.4
Brain gene expression 0 0.000 1.4
Brain isoform ratio 0 0.000 1.4
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.4
Eye alternative polyA 0 0.000 1.5
Eye alternative TSS 0 0.000 1.4
Eye gene expression 0 0.000 1.4
Eye isoform ratio 0 0.000 1.4
Eye intron excision ratio 0 0.000 1.5
Eye mRNA stability 0 0.000 1.6
IL alternative polyA 0 0.000 1.5
IL alternative TSS 0 0.000 1.4
IL gene expression 0 0.000 1.5
IL isoform ratio 0 0.000 1.5
IL intron excision ratio 0 0.000 1.4
IL mRNA stability 0 0.000 1.4
LHb alternative polyA 0 0.000 1.3
LHb alternative TSS 0 0.000 1.2
LHb gene expression 0 0.000 1.4
LHb isoform ratio 0 0.000 1.5
LHb intron excision ratio 0 0.000 1.3
LHb mRNA stability 0 0.000 1.5
Liver alternative polyA 0 0.000 1.4
Liver alternative TSS 0 0.000 1.4
Liver gene expression 0 0.000 1.4
Liver isoform ratio 0 0.000 1.4
Liver intron excision ratio 0 0.000 1.3
Liver mRNA stability 0 0.000 1.3
NAcc alternative polyA 0 0.000 1.5
NAcc alternative TSS 0 0.000 1.5
NAcc gene expression 0 0.000 1.4
NAcc isoform ratio 0 0.000 1.4
NAcc intron excision ratio 0 0.000 1.3
NAcc mRNA stability 0 0.000 1.4
OFC alternative polyA 0 0.000 1.6
OFC alternative TSS 0 0.000 1.2
OFC gene expression 0 0.000 1.4
OFC isoform ratio 0 0.000 1.5
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 0 0.000 1.4
PL alternative polyA 0 0.000 1.4
PL alternative TSS 0 0.000 1.6
PL gene expression 0 0.000 1.4
PL isoform ratio 2 0.090 1.5
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 1 0.034 1.4

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.