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chr14:8,196,668-10,208,170

Best TWAS P=9.617847e-08 · Best GWAS P=1.861017e-07 conditioned to 0.2919032

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Sec31a	isoform ratio	ENSRNOT00000097169	0.05	0.02	blup	3203	0.03	7.9e-04	5.0	5.3	1.0e-07	-0.94	0.35	0.63	FALSE
2	Brain	Lin54	alternative TSS	ENSRNOT00000003006	0.03	0.02	lasso	2	0.02	1.2e-02	-5.2	-5.2	1.9e-07	0.96	0.31	0.59	FALSE
3	Brain	Lin54	alternative TSS	ENSRNOT00000003006	0.04	0.02	blup	3225	0.03	1.5e-03	-5.2	-5.2	2.5e-07	0.87	0.30	0.67	FALSE
4	Brain	Cops4	gene expression	ENSRNOG00000023650	0.15	0.10	enet	17	0.15	1.9e-13	-5.2	-5.2	2.5e-07	0.78	0.27	0.73	FALSE
5	Eye	Tmem150c	gene expression	ENSRNOG00000002258	0.31	0.10	blup	3691	0.15	2.9e-03	4.9	5.2	2.0e-07	-0.89	0.41	0.34	FALSE
6	LHb	Coq2	gene expression	ENSRNOG00000002194	0.24	0.08	top1	1	0.08	6.3e-03	5.1	-5.1	2.9e-07	0.90	0.17	0.06	FALSE
7	NAcc2	Plac8	gene expression	ENSRNOG00000002217	0.13	0.07	blup	3311	0.08	3.0e-05	-4.7	5.1	2.9e-07	-0.91	0.35	0.65	FALSE
8	NAcc2	Cops4	gene expression	ENSRNOG00000023650	0.06	0.01	blup	3306	0.02	3.4e-02	4.5	-5.3	1.5e-07	0.86	0.36	0.29	FALSE
9	NAcc2	Lin54	mRNA stability	ENSRNOG00000002203	0.07	0.02	blup	3225	0.04	2.0e-03	-4.8	-5.3	9.6e-08	0.89	0.37	0.51	TRUE
10	OFC	Hpse	gene expression	ENSRNOG00000002188	0.21	0.17	top1	1	0.17	7.0e-05	5.1	5.1	2.9e-07	-0.90	0.17	0.07	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.