Best TWAS P=4.41e-09 · Best GWAS P=3.37e-07 conditioned to 3.90e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Pecam1 | gene expression | ENSRNOG00000066008 | 0.08 | 66 | 0.05 | 3.6e-06 | 5.44 | 5.23e-08 | 0.53 | FALSE |
| Adipose | Ace | mRNA stability | ENSRNOG00000062101 | 0.17 | 32 | 0.12 | 3.8e-13 | -5.33 | 9.72e-08 | 0.78 | FALSE |
| Brain | Dcaf7 | mRNA stability | ENSRNOG00000042245 | 0.06 | 12 | 0.04 | 1.5e-04 | -5.23 | 1.73e-07 | 0.63 | FALSE |
| Liver | Map3k3 | gene expression | ENSRNOG00000061424 | 0.03 | 1859 | 0.01 | 1.1e-02 | 5.87 | 4.41e-09 | 0.48 | TRUE |
| Liver | Ddx42 | mRNA stability | ENSRNOG00000009474 | 0.04 | 2012 | 0.01 | 9.5e-03 | 5.5 | 3.86e-08 | 0.7 | FALSE |
| NAcc | ENSRNOG00000062516 | gene expression | ENSRNOG00000062516 | 0.19 | 22 | 0.05 | 2.5e-04 | 5.1 | 3.33e-07 | 0.59 | FALSE |
| NAcc | Ace | isoform ratio | ENSRNOT00000119881 | 0.1 | 2086 | 0.04 | 1.0e-03 | -5.27 | 1.39e-07 | 0.48 | FALSE |
| PL | Ace | alternative polyA | ENSRNOT00000010627 | 0.17 | 2086 | 0.07 | 8.5e-06 | 5.15 | 2.66e-07 | 0.81 | FALSE |
| PL | Ace | alternative polyA | ENSRNOT00000119881 | 0.16 | 2086 | 0.07 | 8.7e-06 | -5.1 | 3.34e-07 | 0.78 | FALSE |