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Total locomotion distance, hab. session 2

Total distance of locomotion during second habituation session for males and females [meters]

Tags: Behavior · Motivation · Novelty · Locomotion

Project: p50_shelly_flagel_2014

2 loci · 3 genes with independent associations · 13 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	140610199	142727457	12	2	1.11e-15	5.32e-16	1.00e+00	Ctsc Grm5
2	chr3	44152620	45549784	1	1	9.17e-09	2.37e-02	9.25e-06	Ly75

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Length with tail	2.82	1	0	0	0	1.00e+00	Ly75
Length without tail	8.83	1	0	0	0	1.00e+00	Ly75
Liver weight, right	6.98	1	0	0	0.99	5.72e-04	Grm5
Retroperitoneal fat weight	8.85	1	1	33.3	0	1.00e+00	Ly75
Intraocular pressure	11.88	3	0	0	-0.99	3.63e-21	Ctsc Grm5 LOC102554680
Tibialis anterior weight	3.75	1	0	0	0	1.00e+00	Ly75
Food consumed during 24 hour testing period	11.76	1	0	0	0	1.00e+00	Ly75
Mean time between licks in bursts	7.84	3	0	0	1	1.42e-19	Ctsc Grm5 LOC102554680
Water consumed over 24 hours	19.18	1	0	0	0	1.00e+00	Ly75
Patch foraging total patch changes 18 sec	13.09	1	0	0	0	1.00e+00	Ly75
Patch foraging time to switch 0 sec	8.77	3	0	0	0.99	1.38e-15	Ctsc Grm5 LOC102554680
Patch foraging water rate 0 sec	6.8	1	0	0	0	1.00e+00	Grm5
Patch foraging water rate 12 sec	12.41	4	1	33.3	-0.99	1.11e-17	Ctsc Grm5 Ifngr1 LOC102554680
Patch foraging water rate 18 sec	20.35	3	3	100	-0.99	2.44e-24	Ctsc Grm5 LOC102554680
Patch foraging water rate 24 sec	7.66	2	0	0	-1	1.74e-04	Ctsc Grm5
Patch foraging water rate 6 sec	7.98	2	0	0	-0.99	1.28e-09	Ctsc Grm5
Locomotor activity	6.86	1	0	0	0	1.00e+00	Ly75
Locomotor testing distance	6.84	1	0	0	0	1.00e+00	Ly75
Light reinforcement 1	10.72	3	0	0	1	1.49e-34	Ctsc Grm5 LOC102554680
Light reinforcement 2	20.63	3	3	100	1	9.45e-37	Ctsc Grm5 LOC102554680
Reaction time mean minus median	14.9	1	0	0	0	1.00e+00	Ifngr1
Reaction time mean minus median AUC	15.11	2	0	0	0	1.00e+00	Ifngr1 Ly75
Reaction time num false alarms	12.61	3	0	0	1	4.90e-32	Ctsc Grm5 LOC102554680
Reaction time num false alarms AUC	10.18	3	0	0	1	1.28e-27	Ctsc Grm5 LOC102554680
Reaction time mean	12.83	2	0	0	0	1.00e+00	Ifngr1 Ly75
Reaction time mean AUC	15.71	2	1	33.3	0	1.00e+00	Ifngr1 Ly75
Median of all reaction times	9.85	1	0	0	0	1.00e+00	Ifngr1
Reaction time omissions	8.94	1	0	0	0	1.00e+00	Ifngr1
Reaction time false alarm rate	12.81	3	0	0	1	4.13e-27	Ctsc Grm5 LOC102554680
Reaction time premature initiation rate	9.14	1	0	0	0	1.00e+00	Ly75
Std. dev. reaction times	16.99	2	1	33.3	0	1.00e+00	Ifngr1 Ly75
Condit. Reinf. active minus inactive responses	28.62	1	1	33.3	0	1.00e+00	Ly75
Condit. Reinf. active-inactive response ratio	11.56	1	0	0	0	1.00e+00	Ly75
Condit. Reinf. active responses	24.88	1	1	33.3	0	1.00e+00	Ly75
Condit. Reinf. lever presses	8.53	1	0	0	0	1.00e+00	Ly75
Condit. Reinf. lever reinforcers received	19.5	1	1	33.3	0	1.00e+00	Ly75
Pavlov. Cond. change in total contacts	11.21	1	0	0	0	1.00e+00	Ly75
Short access day 1 total infusions	10.37	2	0	0	1	2.43e-12	Ctsc Grm5
Locomotion velocity, session 1	16.18	3	0	0	-1	8.78e-32	Ctsc Grm5 LOC102554680
Locomotion distance, session 1	13.38	1	0	0	0	1.00e+00	Ifngr1
Locomotion velocity, session 2	8.84	2	0	0	0	1.00e+00	Ctsc Grm5
Locomotion distance, session 3	10.72	3	0	0	-0.8	9.00e-03	Ctsc Grm5 Ly75
Stereotopy head waving bouts, day 3	9.54	3	0	0	1	2.56e-23	Ctsc Grm5 LOC102554680
Stereotopy head waving bouts, day 7	23.7	1	0	0	0	1.00e+00	Ly75
Stereotopy head waving duration, day 7	21.6	1	0	0	0	1.00e+00	Ly75
Locomotion velocity, session 8	8.71	2	0	0	-1	6.59e-05	Ctsc Grm5
Degree of sensitization distance	10.32	1	0	0	0	1.00e+00	Ly75
Degree of sensitization stereotypy	38.66	1	1	33.3	0	1.00e+00	Ly75
Condit. Reinf. active minus inactive responses	16.76	1	0	0	0	1.00e+00	Ly75
Condit. Reinf. active-inactive response ratio	9.84	1	0	0	0	1.00e+00	Ly75
Condit. Reinf. active responses	13.63	1	0	0	0	1.00e+00	Ly75
Incentive salience index mean	15.42	1	0	0	0	1.00e+00	Ly75
Total zone transitions, hab. session 1	8.25	5	0	0	-0.62	4.10e-02	Ctsc Grm5 Ifngr1 LOC102554680 Ly75
Total locomotion distance, hab. session 1	26.83	4	3	100	1	2.40e-42	Ctsc Grm5 Ifngr1 LOC102554680
Locomotion velocity, hab. session 1	27.79	4	3	100	1	1.96e-44	Ctsc Grm5 Ifngr1 LOC102554680
Total zone transitions, hab. session 2	17.15	2	0	0	0	1.00e+00	Ifngr1 Ly75
Locomotion velocity, hab. session 2	30.86	5	5	166.7	1	3.17e-53	Ctsc Grm5 Ifngr1 LOC102554680 Ly75
Total locomotion distance, NPP test	38.34	3	3	100	1	1.83e-40	Ctsc Grm5 LOC102554680
Locomotion velocity, NPP test	36.93	3	3	100	1	1.66e-42	Ctsc Grm5 LOC102554680
Bone: apparent density	27.67	1	1	33.3	0	1.00e+00	Ly75
Bone surface	47.59	1	1	33.3	0	1.00e+00	Ly75
Bone volume	43.15	1	1	33.3	0	1.00e+00	Ly75
Bone: connectivity density	21.24	1	1	33.3	0	1.00e+00	Ly75
Bone: cortical apparent density	18.66	1	0	0	0	1.00e+00	Ly75
Bone: cortical area	12.58	1	0	0	0	1.00e+00	Ly75
Bone: cortical tissue density	17.88	1	0	0	0	1.00e+00	Ly75
Bone: elastic work	15.82	1	0	0	0	1.00e+00	Ly75
Bone: endosteal estimation	9.05	1	0	0	0	1.00e+00	Ly75
Bone: final force	35.73	1	1	33.3	0	1.00e+00	Ly75
Bone: final moment	48.32	1	1	33.3	0	1.00e+00	Ly75
Bone: marrow area	9.02	1	0	0	0	1.00e+00	Ly75
Bone: maximum force	20.87	1	1	33.3	0	1.00e+00	Ly75
Bone: maximum moment	29.34	1	1	33.3	0	1.00e+00	Ly75
Bone: minimum diameter	8.69	1	0	0	0	1.00e+00	Ly75
Bone: periosteal estimation	14.82	1	1	33.3	0	1.00e+00	Ly75
Bone: periosteal perimeter	7.52	1	0	0	0	1.00e+00	Ly75
Bone: post-yield work	18.38	1	0	0	0	1.00e+00	Ifngr1
Bone: stiffness	8.31	2	0	0	0	1.00e+00	Ifngr1 Ly75
Bone: trabecular number	35.45	1	1	33.3	0	1.00e+00	Ly75
Bone: trabecular spacing	60.24	1	1	33.3	0	1.00e+00	Ly75
Bone: trabecular thickness	47.42	1	1	33.3	0	1.00e+00	Ly75
Sum of active levers in priming session hrs 5-6	10.93	2	0	0	0	1.00e+00	Ctsc Grm5
Rest time, locomotor task time 1	12.3	1	0	0	0	1.00e+00	Ly75
Distance moved, locomotor task time 1	13.8	1	0	0	0	1.00e+00	Ly75
Weight adjusted by age	20.87	1	0	0	0	1.00e+00	Ly75
Locomotion in novel chamber	34.01	1	1	33.3	0	1.00e+00	Ly75
Food seeking constrained by brief footshock	13.79	1	0	0	0	1.00e+00	Ly75
Run reversals in cocaine runway, females	21.72	1	0	0	0	1.00e+00	Ly75
Latency to leave start box in cocaine runway	13.16	1	0	0	1	3.31e-05	Grm5
Cu content in liver	13.19	2	0	0	0	1.00e+00	Ifngr1 Ly75
K content in liver	12.92	1	0	0	0	1.00e+00	Ly75
Mg content in liver	13.79	1	0	0	0	1.00e+00	Ly75
Mn content in liver	32.26	1	1	33.3	0	1.00e+00	Ly75
Na content in liver	11.38	2	0	0	-0.67	2.16e-01	Ctsc Ly75
Sr content in liver	14.16	1	0	0	0	1.00e+00	Ly75
Zn content in liver	12.81	1	0	0	0	1.00e+00	Ly75

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.38
Adipose	alternative TSS	0	0	1.33
Adipose	gene expression	0	0	1.31
Adipose	isoform ratio	2	0	1.32
Adipose	intron excision ratio	2	0.1	1.35
Adipose	mRNA stability	0	0	1.32
BLA	alternative polyA	0	0	1.26
BLA	alternative TSS	0	0	1.29
BLA	gene expression	1	0	1.36
BLA	isoform ratio	2	0.1	1.36
BLA	intron excision ratio	0	0	1.26
BLA	mRNA stability	0	0	1.31
Brain	alternative polyA	2	0.1	1.4
Brain	alternative TSS	0	0	1.26
Brain	gene expression	2	0	1.33
Brain	isoform ratio	3	0.1	1.33
Brain	intron excision ratio	0	0	1.27
Brain	mRNA stability	1	0	1.29
Eye	alternative polyA	0	0	1.56
Eye	alternative TSS	0	0	1.32
Eye	gene expression	1	0.1	1.37
Eye	isoform ratio	0	0	1.32
Eye	intron excision ratio	1	0.1	1.6
Eye	mRNA stability	0	0	1.43
IL	alternative polyA	0	0	1.3
IL	alternative TSS	0	0	1.39
IL	gene expression	1	0	1.37
IL	isoform ratio	0	0	1.39
IL	intron excision ratio	0	0	1.28
IL	mRNA stability	0	0	1.28
LHb	alternative polyA	0	0	1.37
LHb	alternative TSS	0	0	1.28
LHb	gene expression	1	0	1.36
LHb	isoform ratio	0	0	1.38
LHb	intron excision ratio	0	0	1.55
LHb	mRNA stability	0	0	1.26
Liver	alternative polyA	0	0	1.32
Liver	alternative TSS	0	0	1.32
Liver	gene expression	1	0	1.29
Liver	isoform ratio	0	0	1.29
Liver	intron excision ratio	0	0	1.27
Liver	mRNA stability	0	0	1.32
NAcc	alternative polyA	0	0	1.34
NAcc	alternative TSS	0	0	1.38
NAcc	gene expression	2	0	1.33
NAcc	isoform ratio	4	0.1	1.35
NAcc	intron excision ratio	0	0	1.3
NAcc	mRNA stability	0	0	1.33
OFC	alternative polyA	0	0	1.37
OFC	alternative TSS	0	0	1.32
OFC	gene expression	1	0	1.4
OFC	isoform ratio	0	0	1.42
OFC	intron excision ratio	0	0	1.29
OFC	mRNA stability	0	0	1.32
PL	alternative polyA	0	0	1.32
PL	alternative TSS	0	0	1.33
PL	gene expression	2	0	1.33
PL	isoform ratio	1	0	1.35
PL	intron excision ratio	0	0	1.28
PL	mRNA stability	0	0	1.3
pVTA	alternative polyA	0	0	1.3
pVTA	alternative TSS	0	0	1.31
pVTA	gene expression	1	0	1.36
pVTA	isoform ratio	0	0	1.33
pVTA	intron excision ratio	0	0	1.27
pVTA	mRNA stability	0	0	1.35
RMTg	alternative polyA	0	0	1.17
RMTg	alternative TSS	0	0	1.29
RMTg	gene expression	0	0	1.24
RMTg	isoform ratio	0	0	1.35
RMTg	intron excision ratio	0	0	1.4
RMTg	mRNA stability	1	0.2	1.29