Short access day 10 total infusions

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr1 166093700 167491708 1 1 8.05e-27 4.25e-04 1.95e-11 Tead1
2 chr7 14449451 15768722 1 1 4.52e-09 3.26e-01 1.00e+00 LOC102551633
3 chr8 33211184 34601262 1 1 1.43e-09 7.02e-02 4.68e-12 Ddx25

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 2.35 1 0 0 0 1e+00 Tead1
BMI without tail 4.08 1 0 0 0 1e+00 Ddx25
Right kidney weight 2.2 1 0 0 0 1e+00 Ddx25
Tail length 6.06 1 0 0 0 1e+00 Ddx25
Length without tail 5.12 1 0 0 0 1e+00 Ddx25
Patch foraging indifference point 0 sec 9.16 2 0 0 0 1e+00 LOC102551633 Tead1
Patch foraging total patch changes 0 sec 8.18 2 0 0 0 1e+00 LOC102551633 Tead1
Patch foraging total patch changes 12 sec 9.53 1 0 0 0 1e+00 Tead1
Patch foraging total patch changes 6 sec 6.2 2 0 0 0 1e+00 LOC102551633 Tead1
Patch foraging time to switch 0 sec 6.02 1 0 0 0 1e+00 Tead1
Patch foraging water rate 24 sec 8.95 1 0 0 0 1e+00 Tead1
Locomotor activity 4.34 2 0 0 0 1e+00 Ddx25 LOC102551633
Locomotor testing distance 4.33 2 0 0 0 1e+00 Ddx25 LOC102551633
Reaction time mean 4.52 2 0 0 0 1e+00 Ddx25 Tead1
Median of all reaction times 4.38 1 0 0 0 1e+00 Tead1
Conditioned reinforcement - actives 6.27 1 0 0 0 1e+00 LOC102551633
Conditioned reinforcement - inactives 10.26 3 0 0 0 1e+00 Ddx25 LOC102551633 Tead1
Conditioned locomotion 53.64 1 1 33.3 0 1e+00 LOC102551633
Intermittent access intake day 1-15 change 43.02 2 1 33.3 0 1e+00 Ddx25 Tead1
Intermittent access intake escalation 41.26 1 1 33.3 0 1e+00 Ddx25
Intermittent access intake escalation 2 18.07 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Intermitt. access day 1 inactive lever presses 17.35 2 1 33.3 0 1e+00 Ddx25 Tead1
Intermitt. access day 15 inactive lever presses 25.67 2 1 33.3 0 1e+00 Ddx25 Tead1
Intermitt. access escalation Index 36.25 2 1 33.3 0 1e+00 Ddx25 LOC102551633
Intermittent access day 1 total infusions 37.92 2 1 33.3 0 1e+00 LOC102551633 Tead1
Intermittent access day 15 total infusions 19.55 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Intermittent access terminal intake (last 3 days) 51.19 2 2 66.7 0 1e+00 Ddx25 LOC102551633
Intermittent access total infusions 28.05 3 2 66.7 0 1e+00 Ddx25 LOC102551633 Tead1
Intermittent access day 1 locomotion 11.44 1 0 0 0 1e+00 Tead1
Intermittent access day 15 total locomotion 32.88 1 1 33.3 0 1e+00 LOC102551633
Intermittent access total locomotion 10.08 2 0 0 0 1e+00 LOC102551633 Tead1
Intermittent access standard deviation 15.63 2 0 0 0 1e+00 Ddx25 Tead1
Cocaine induced anxiety 12.68 1 0 0 0 1e+00 Ddx25
Baseline Anxiety 5.61 1 0 0 0 1e+00 Ddx25
Lifetime Intake 34.3 3 2 66.7 0 1e+00 Ddx25 LOC102551633 Tead1
Incentive Sensitization - Responses 21.05 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Incentive Sensitization - Breakpoint 20.9 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Progressive ratio test 1 active lever presses 17.18 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Progressive ratio test 1 breakpoint 22.54 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Progressive ratio test 1 inactive lever presses 16.85 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Progressive ratio test 2 active lever presses 30.08 2 1 33.3 0 1e+00 Ddx25 Tead1
Progressive ratio test 2 breakpoint 31.55 2 1 33.3 0 1e+00 Ddx25 Tead1
Progressive ratio test 2 inactive lever presses 22.41 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Total sessions with >9 infusions 21.06 2 0 0 0 1e+00 Ddx25 Tead1
Short access day 1 total inactive lever presses 7.07 1 0 0 0 1e+00 LOC102551633
Short access day 10 total inactive lever presses 15.16 2 0 0 0 1e+00 LOC102551633 Tead1
Short access day 1 total infusions 44.74 3 2 66.7 0 1e+00 Ddx25 LOC102551633 Tead1
Short access total infusions 51.17 3 3 100 0 1e+00 Ddx25 LOC102551633 Tead1
Short access day 1 locomotion 16.31 2 0 0 0 1e+00 LOC102551633 Tead1
Short access day 10 total locomotion 11.38 1 0 0 0 1e+00 Ddx25
Short access total locomotion 27.61 1 1 33.3 0 1e+00 Tead1
Compulsive drug intake 22.25 1 0 0 0 1e+00 Tead1
One hour access (0.3 mA shock) 70.35 1 1 33.3 0 1e+00 Ddx25
One hour access (shock baseline) 23.24 2 1 33.3 0 1e+00 Ddx25 LOC102551633
Number of responses in last shaping day 20.89 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Degree of sensitization distance 11.08 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. lever latency 5.45 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. latency score 4.54 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. lever contacts 5.74 1 0 0 0 1e+00 LOC102551633
Bone: cortical area 7.52 1 0 0 0 1e+00 Ddx25
Bone: cortical porosity 5.3 1 0 0 0 1e+00 Tead1
Bone: cortical porosity 7.17 1 0 0 0 1e+00 Tead1
Bone: cortical thickness 4.39 1 0 0 0 1e+00 Ddx25
Bone: cortical thickness 5.77 1 0 0 0 1e+00 Ddx25
Bone: final force 4.62 2 0 0 0 1e+00 Ddx25 LOC102551633
Bone: final moment 4.16 2 0 0 0 1e+00 Ddx25 LOC102551633
Bone: maximum force 5.29 2 0 0 0 1e+00 Ddx25 LOC102551633
Bone: maximum moment 4.67 2 0 0 0 1e+00 Ddx25 LOC102551633
Bone: minimum diameter 3.6 1 0 0 0 1e+00 Ddx25
Bone: periosteal estimation 3.75 1 0 0 0 1e+00 Ddx25
Bone: stiffness 4.85 2 0 0 0 1e+00 Ddx25 LOC102551633
Breakpoint value in progressive ratio session 11.08 1 0 0 0 1e+00 Tead1
Distance traveled before self-admin 26.05 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Distance traveled after self-admin 23.47 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Delta time in closed arm before/after self-admin 6.42 1 0 0 0 1e+00 Ddx25
Extinction: sum of active levers before priming 24.99 2 0 0 0 1e+00 Ddx25 LOC102551633
Active lever presses in extinction session 6 9.49 1 0 0 0 1e+00 Ddx25
Delta distance traveled before/after self-admin 6.76 1 0 0 0 1e+00 Ddx25
Delta ambulatory time before/after self-admin 13.84 2 0 0 0 1e+00 Ddx25 LOC102551633
Time in closed arm before self-admin 11.48 1 0 0 0 1e+00 Tead1
Time in closed arm after self-admin 8.01 2 0 0 0 1e+00 LOC102551633 Tead1
Time in open arm before self-admin 28.75 1 1 33.3 0 1e+00 LOC102551633
Time in open arm after self-admin 5.82 1 0 0 0 1e+00 LOC102551633
Sum of active levers in priming session hrs 5-6 18.99 1 0 0 0 1e+00 LOC102551633
Time to tail flick, vehicle, before self-admin 31.43 2 1 33.3 0 1e+00 Ddx25 LOC102551633
Time to tail flick, vehicle, after self-admin 51.7 1 1 33.3 0 1e+00 LOC102551633
Time to tail flick, test, before self-admin 5.88 1 0 0 0 1e+00 Ddx25
Delta time to tail flick, vehicle, before/after SA 64.27 2 1 33.3 0 1e+00 LOC102551633 Tead1
Ambulatory time before self-admin 16.28 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Ambulatory time after self-admin 13.83 3 0 0 0 1e+00 Ddx25 LOC102551633 Tead1
Total heroin consumption 15.5 3 1 33.3 0 1e+00 Ddx25 LOC102551633 Tead1
Seeking ratio, delayed vs. immediate footshock 7.27 2 0 0 0 1e+00 LOC102551633 Tead1
Run reversals in cocaine runway, males 8.37 1 0 0 0 1e+00 Ddx25
Latency to leave start box in cocaine runway 5.91 1 0 0 0 1e+00 Ddx25
Latency to leave start box in cocaine runway, M 10.76 1 0 0 0 1e+00 Ddx25
Co content in liver 12.69 1 0 0 0 1e+00 LOC102551633
Fe content in liver 7.51 1 0 0 0 1e+00 LOC102551633
K content in liver 11.66 1 0 0 0 1e+00 LOC102551633
Na content in liver 44.6 1 1 33.3 0 1e+00 LOC102551633
Rb content in liver 16.75 1 0 0 0 1e+00 LOC102551633
Se content in liver 12.37 1 0 0 0 1e+00 LOC102551633
Sr content in liver 9.74 1 0 0 0 1e+00 Ddx25

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.09
Adipose alternative TSS 0 0 1.11
Adipose gene expression 1 0 1.11
Adipose isoform ratio 0 0 1.13
Adipose intron excision ratio 0 0 1.08
Adipose mRNA stability 0 0 1.11
BLA alternative polyA 0 0 1.08
BLA alternative TSS 0 0 1.12
BLA gene expression 0 0 1.12
BLA isoform ratio 0 0 1.12
BLA intron excision ratio 0 0 1.12
BLA mRNA stability 0 0 1.15
Brain alternative polyA 0 0 1.07
Brain alternative TSS 0 0 1.12
Brain gene expression 0 0 1.12
Brain isoform ratio 0 0 1.11
Brain intron excision ratio 0 0 1.08
Brain mRNA stability 0 0 1.1
Eye alternative polyA 0 0 0.98
Eye alternative TSS 0 0 1.14
Eye gene expression 0 0 1.23
Eye isoform ratio 0 0 1.2
Eye intron excision ratio 0 0 1.03
Eye mRNA stability 0 0 1.22
IL alternative polyA 0 0 1.1
IL alternative TSS 0 0 1.08
IL gene expression 0 0 1.08
IL isoform ratio 0 0 1.07
IL intron excision ratio 0 0 1.09
IL mRNA stability 0 0 1.15
LHb alternative polyA 0 0 1.04
LHb alternative TSS 0 0 1.35
LHb gene expression 0 0 1.14
LHb isoform ratio 0 0 1.09
LHb intron excision ratio 0 0 1.08
LHb mRNA stability 0 0 1.21
Liver alternative polyA 0 0 1.06
Liver alternative TSS 0 0 1.22
Liver gene expression 0 0 1.11
Liver isoform ratio 0 0 1.18
Liver intron excision ratio 0 0 1.16
Liver mRNA stability 0 0 1.14
NAcc alternative polyA 0 0 1.08
NAcc alternative TSS 1 0 1.12
NAcc gene expression 0 0 1.12
NAcc isoform ratio 0 0 1.09
NAcc intron excision ratio 0 0 1.12
NAcc mRNA stability 0 0 1.12
OFC alternative polyA 0 0 1.13
OFC alternative TSS 0 0 1.15
OFC gene expression 0 0 1.11
OFC isoform ratio 0 0 1.06
OFC intron excision ratio 0 0 1.01
OFC mRNA stability 0 0 1.1
PL alternative polyA 0 0 1.11
PL alternative TSS 0 0 1.13
PL gene expression 0 0 1.11
PL isoform ratio 0 0 1.16
PL intron excision ratio 0 0 1.1
PL mRNA stability 0 0 1.12
pVTA alternative polyA 0 0 1.1
pVTA alternative TSS 0 0 1.09
pVTA gene expression 0 0 1.15
pVTA isoform ratio 0 0 1.13
pVTA intron excision ratio 0 0 1.1
pVTA mRNA stability 0 0 1.15
RMTg alternative polyA 1 0.2 1.16
RMTg alternative TSS 0 0 0.98
RMTg gene expression 0 0 1.16
RMTg isoform ratio 0 0 1.11
RMTg intron excision ratio 0 0 1.1
RMTg mRNA stability 0 0 1.21