Hub : Genes

Clba1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	intron excision ratio	chr6:131885909:131888095	0.37	0.2	2.5e-04	0.19	0.21	0.29	0.22	7.2e-04	3.3e-04	2.3e-05	3.0e-04
2	Eye	intron excision ratio	chr6:131886607:131888095	0.38	0.2	8.5e-05	0.23	0.22	0.31	0.19	1.6e-04	3.2e-04	9.3e-06	6.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	1.9	6.3	6.4	2.5	-2.5
BMI without tail	0.5	1.0	1.0	1.0	-1.0
Body weight	1.2	4.9	5.1	-2.2	2.3
Epididymis fat weight	3.0	6.9	7.0	2.7	-2.6
Glucose	0.1	0.2	0.2	-0.5	0.4
Heart weight	0.0	0.0	0.1	0.2	-0.2
Left kidney weight	2.1	6.0	6.1	-2.5	2.5
Right kidney weight	1.4	4.0	4.1	-2.0	2.0
Tail length	5.9	17.8	18.0	-4.2	4.2
Length with tail	8.9	32.8	33.3	-5.7	5.8
Length without tail	4.1	9.1	9.3	-3.0	3.0
Liver weight, left	2.2	3.5	3.5	-1.9	1.9
Liver weight, right	0.3	0.5	0.5	-0.6	0.7
Parametrial fat weight	0.0	0.0	0.0	0.2	-0.2
Retroperitoneal fat weight	0.0	0.1	0.1	0.4	-0.3
Intraocular pressure	0.0	0.0	0.0	-0.0	0.0
Extensor digitorum longus weight	9.0	36.0	36.5	-6.0	6.0
Soleus weight	1.1	3.3	3.7	-1.7	1.9
Tibialis anterior weight	0.7	2.4	2.5	-1.5	1.6
Tibia length	0.0	0.1	0.1	-0.3	0.3
Number of licking bursts	0.4	0.5	0.5	0.7	-0.7
Food consumed during 24 hour testing period	1.2	1.4	1.5	-1.2	1.2
Times rat made contact with spout	0.4	0.4	0.5	-0.6	0.7
Mean time between licks in bursts	0.7	0.9	0.9	0.9	-1.0
Mean num. licks in bursts	0.9	1.1	1.2	-1.0	1.1
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.2	0.2
Water consumed over 24 hours	2.3	2.7	2.7	-1.7	1.6
Indifference point 0 sec	4.4	7.1	7.1	-2.7	2.7
Indifference point AUC	3.4	4.0	4.2	-1.9	2.1
Indifference point function ln k	0.7	1.1	1.1	-1.1	1.0
Indifference point function log k	0.7	1.1	1.1	-1.1	1.0
Delay discounting total patch changes 0 sec	5.4	8.8	8.8	-2.9	3.0
Delay discounting total patch changes 12 sec	3.3	4.4	4.4	-2.1	2.1
Delay discounting total patch changes 18 sec	1.9	2.5	2.5	-1.6	1.6
Delay discounting total patch changes 24 sec	0.7	0.9	0.9	-0.9	0.9
Delay discounting total patch changes 6 sec	3.2	4.9	5.1	-2.2	2.3
Delay discounting time to switch 0 sec	10.9	16.7	16.8	4.1	-4.1
Delay discounting water rate 0 sec	16.8	26.7	26.7	-5.2	5.2
Delay discounting water rate 12 sec	9.6	14.4	14.7	-3.8	3.8
Delay discounting water rate 18 sec	5.3	7.0	7.1	-2.7	2.6
Delay discounting water rate 24 sec	3.5	4.8	5.0	-2.2	2.2
Delay discounting water rate 6 sec	4.4	6.5	6.5	-2.5	2.5
Locomotor activity	0.2	0.3	0.3	-0.6	0.5
Locomotor testing distance	0.2	0.3	0.3	-0.5	0.5
Locomotor testing rearing	2.1	3.3	3.3	1.8	-1.8
Light reinforcement 1	0.0	0.0	0.0	0.1	-0.2
Light reinforcement 2	1.9	2.5	2.5	1.6	-1.6
Reaction time number correct	4.1	5.9	5.9	-2.4	2.4
Reaction time mean minus median	0.0	0.0	0.0	-0.1	0.1
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.3	0.4
Reaction time num false alarms	2.1	2.9	3.0	-1.7	1.7
Reaction time num false alarms AUC	2.3	3.2	3.3	-1.8	1.8
Reaction time trials correct on left	4.1	5.9	5.9	-2.4	2.4
Reaction time trials on left	4.2	6.0	6.1	-2.5	2.5
Reaction time mean	0.6	0.9	0.9	0.9	-0.9
Reaction time mean AUC	0.3	0.4	0.4	0.6	-0.6
Median of all reaction times	0.4	0.6	0.6	0.8	-0.8
Reaction time omissions	2.1	2.9	2.9	-1.7	1.7
Reaction time false alarm rate	0.3	0.4	0.4	-0.6	0.6
Reaction time premature initiation rate	0.2	0.3	0.3	-0.6	0.5
Reaction time premature initiations	1.9	2.7	2.8	-1.7	1.6
Std. dev. reaction times	0.2	0.3	0.4	0.6	-0.6
Reaction time trials completed	4.2	6.0	6.1	-2.5	2.5
Reaction time trials AUC	4.2	6.1	6.1	-2.5	2.5
Social response proportion	0.0	0.0	0.0	0.1	-0.2
Social responses	0.1	0.1	0.1	0.3	-0.3
Social time	0.9	1.2	1.3	-1.1	1.0
Conditioned locomotion	1.5	1.8	1.8	-1.3	1.3
Cocaine response after cond. corrected	0.2	0.2	0.3	0.5	-0.4
Cocaine response after cond. not corrected	1.3	1.5	1.5	1.2	-1.2
Cocaine response before conditioning	2.8	3.4	3.6	1.8	-1.9
Saline control response	0.0	0.0	0.0	-0.2	0.2
Condit. Reinf. active minus inactive responses	0.5	0.6	0.7	-0.8	0.7
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.5	0.5
Condit. Reinf. active responses	0.0	0.1	0.1	-0.3	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.4	-0.4
Condit. Reinf. lever presses	1.6	2.1	2.3	1.4	-1.5
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.4	0.3
Pavlov. Cond. lever latency	2.6	3.6	3.8	-1.8	1.9
Pavlov. Cond. magazine entry latency	4.0	4.5	4.6	2.1	-2.1
Pavlov. Cond. change in total contacts	6.1	8.6	8.8	2.9	-3.0
Pavlov. Cond. index score	4.6	6.0	6.2	2.4	-2.5
Pavlov. Cond. latency score	4.6	5.8	5.9	2.4	-2.4
Pavlov. Cond. lever contacts	3.1	4.3	4.5	2.0	-2.1
Pavlov. Cond. magazine entry number	3.0	3.6	3.7	-1.9	1.9
Pavlov. Cond. intertrial magazine entries	5.6	7.2	7.3	-2.7	2.7
Pavlov. Cond. lever-magazine prob. diff.	5.4	7.0	7.2	2.6	-2.7
Pavlov. Cond. response bias	3.1	4.3	4.5	2.0	-2.1
Conditioned reinforcement - actives	1.7	1.7	1.7	-1.3	1.3
Conditioned reinforcement - inactives	0.7	0.8	0.8	-0.9	0.9
Conditioned locomotion	0.1	0.1	0.1	0.4	-0.4
Intermittent access intake day 1-15 change	1.5	1.5	1.5	1.2	-1.2
Intermittent access intake escalation	1.5	1.5	1.5	1.2	-1.2
Intermittent access intake escalation 2	0.3	0.3	0.3	0.6	-0.5
Intermitt. access day 1 inactive lever presses	3.7	4.0	4.1	-2.0	2.0
Intermitt. access day 15 inactive lever presses	1.2	1.4	1.4	-1.2	1.2
Intermitt. access escalation Index	0.1	0.1	0.1	-0.3	0.3
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	-0.1
Intermittent access day 15 total infusions	1.2	1.4	1.4	1.2	-1.2
Intermittent access terminal intake (last 3 days)	1.4	1.6	1.6	1.3	-1.2
Intermittent access total infusions	0.2	0.2	0.2	0.5	-0.4
Intermittent access day 1 locomotion	0.3	0.3	0.3	0.5	-0.5
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.3	-0.3
Intermittent access total locomotion	0.0	0.0	0.0	0.2	-0.2
Intermittent access standard deviation	2.0	2.2	2.3	1.5	-1.4
Cocaine induced anxiety	0.8	1.0	1.0	-1.0	1.0
Post-drug Anxiety	0.5	0.6	0.6	-0.8	0.8
Baseline Anxiety	1.2	1.3	1.3	1.1	-1.1
Lifetime Intake	0.1	0.1	0.1	0.3	-0.3
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	-0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.0	-0.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	0.1	-0.1
Progressive ratio test 1 inactive lever presses	3.7	3.9	4.0	-2.0	2.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.0	-0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	0.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.6	-0.8	0.7
Total sessions with >9 infusions	0.0	0.0	0.0	0.0	-0.0
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.2	0.1
Short access day 10 total inactive lever presses	0.9	0.9	1.0	-1.0	1.0
Short access day 1 total infusions	0.2	0.2	0.2	-0.4	0.4
Short access day 10 total infusions	0.2	0.2	0.3	0.5	-0.5
Short access total infusions	0.3	0.3	0.3	0.5	-0.6
Short access day 1 locomotion	0.3	0.3	0.3	0.5	-0.5
Short access day 10 total locomotion	0.2	0.2	0.2	0.4	-0.4
Short access total locomotion	0.0	0.0	0.0	0.1	-0.1
Compulsive drug intake	0.1	0.1	0.1	-0.2	0.3
One hour access (0.3 mA shock)	0.3	0.4	0.4	-0.6	0.6
One hour access (shock baseline)	0.0	0.0	0.0	0.0	-0.0
Number of responses in last shaping day	0.5	0.5	0.6	0.7	-0.8
Context. condit. distance diff. score	3.0	3.7	3.8	-1.9	1.9
Locomotion velocity, session 1	0.3	0.3	0.4	-0.6	0.6
Locomotion distance, session 1	0.2	0.3	0.3	0.6	-0.5
Locomotion velocity, session 2	0.1	0.1	0.1	0.2	-0.3
Locomotion distance, session 2	0.4	0.6	0.7	0.8	-0.8
Locomotion velocity, session 3	0.0	0.0	0.0	0.2	-0.2
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.1
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.1	0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.3	0.3
Locomotion velocity, session 7	0.0	0.0	0.0	0.1	-0.0
Locomotion distance, session 7	0.7	0.9	0.9	1.0	-1.0
Stereotopy head waving bouts, day 7	2.6	3.0	3.1	-1.7	1.7
Stereotopy head waving duration, day 7	1.3	1.6	1.7	-1.2	1.3
Locomotion velocity, session 8	1.4	1.6	1.7	-1.3	1.3
Locomotion distance, session 8	0.3	0.4	0.4	-0.6	0.6
Degree of sensitization distance	0.2	0.2	0.3	0.5	-0.5
Degree of sensitization stereotypy	1.0	1.0	1.1	-1.0	1.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.5	-0.5
Condit. Reinf. active-inactive response ratio	2.0	2.2	2.2	1.5	-1.4
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.2
Condit. Reinf. inactive responses	2.6	3.0	3.1	-1.7	1.8
Incentive salience index mean	0.0	0.0	0.0	0.2	-0.1
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.1	0.2
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.2	-0.2
Time in novel zone, hab. session 1	0.4	0.4	0.4	0.6	-0.7
Total zone transitions, hab. session 1	0.3	0.5	0.5	0.7	-0.7
Total locomotion distance, hab. session 1	0.1	0.2	0.2	-0.5	0.4
Locomotion velocity, hab. session 1	0.6	0.9	1.0	-1.0	0.9
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.2	0.3
Time in novel zone, hab. session 2	0.5	0.5	0.5	0.6	-0.7
Total zone transitions, hab. session 2	0.1	0.2	0.2	0.4	-0.4
Total locomotion distance, hab. session 2	0.5	0.7	0.7	-0.9	0.8
Locomotion velocity, hab. session 2	0.7	1.0	1.0	-1.0	1.0
Novel to familiar place preference ratio	0.5	0.6	0.6	0.8	-0.8
Novelty place preference	0.5	0.5	0.6	0.7	-0.7
Time in novel zone, NPP test	0.2	0.2	0.2	0.4	-0.4
Total zone transitions, NPP test	0.6	0.8	0.8	-0.9	0.9
Total locomotion distance, NPP test	0.6	0.9	0.9	-0.9	0.9
Locomotion velocity, NPP test	0.5	0.7	0.7	-0.8	0.8
Pavlov. Cond. lever latency	0.2	0.2	0.3	-0.5	0.4
Pavlov. Cond. magazine entry latency	0.2	0.2	0.2	0.5	-0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	-0.2
Pavlov. Cond. index score	0.2	0.3	0.4	0.6	-0.5
Pavlov. Cond. latency score	0.2	0.2	0.3	0.5	-0.4
Pavlov. Cond. lever contacts	0.7	0.8	0.9	0.9	-0.9
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	-0.5	0.4
Pavlov. Cond. intertrial magazine entries	9.1	10.9	11.1	-3.3	3.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.3	0.6	-0.5
Pavlov. Cond. response bias	0.2	0.2	0.2	0.5	-0.4
Bone: apparent density	0.0	0.0	0.0	-0.1	0.1
Bone surface	0.2	0.3	0.3	0.5	-0.6
Bone volume	0.1	0.1	0.2	0.3	-0.4
Bone: connectivity density	0.2	0.2	0.2	-0.5	0.5
Bone: cortical apparent density	5.4	7.1	7.2	-2.7	2.6
Bone: cortical area	0.2	0.2	0.3	-0.5	0.5
Bone: cortical porosity	0.1	0.2	0.2	-0.4	0.4
Bone: cortical porosity	0.0	0.0	0.0	-0.2	0.2
Bone: cortical thickness	0.3	0.6	0.6	-0.7	0.8
Bone: cortical thickness	1.0	1.2	1.2	-1.1	1.1
Bone: cortical tissue density	5.5	7.1	7.2	-2.7	2.6
Bone: elastic displacement	0.1	0.1	0.2	-0.4	0.3
Bone: elastic work	0.2	0.2	0.3	0.4	-0.5
Bone: endosteal estimation	0.5	1.2	1.3	1.0	-1.2
Bone: endosteal perimeter	0.1	0.3	0.3	0.5	-0.6
Bone: final force	0.0	0.0	0.1	0.1	-0.2
Bone: final moment	0.0	0.0	0.0	-0.1	-0.0
Bone: marrow area	0.5	1.1	1.3	1.0	-1.1
Bone: maximum diameter	0.1	0.2	0.2	0.5	-0.5
Bone: maximum force	0.0	0.0	0.0	-0.1	-0.0
Bone: maximum moment	0.0	0.0	0.0	-0.2	0.1
Bone: minimum diameter	0.6	1.0	1.1	-1.0	1.0
Bone: periosteal estimation	0.0	0.1	0.1	0.2	-0.4
Bone: periosteal perimeter	0.0	0.0	0.0	0.1	-0.2
Bone: post-yield work	1.7	2.3	2.4	-1.5	1.5
Bone: stiffness	0.9	1.5	1.5	-1.2	1.2
Bone: tissue strength	0.2	0.2	0.3	0.4	-0.5
Bone: trabecular number	0.2	0.3	0.3	-0.6	0.6
Bone: trabecular spacing	0.0	0.0	0.0	0.1	-0.1
Bone: trabecular thickness	0.0	0.0	0.0	-0.2	0.2
Bone: trabecular tissue density	0.0	0.0	0.0	-0.0	0.1
Breakpoint value in progressive ratio session	0.2	0.2	0.2	0.5	-0.5
Distance traveled before self-admin	0.8	0.8	0.9	0.9	-0.9
Distance traveled after self-admin	0.4	0.4	0.4	-0.7	0.6
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	0.1
Delta time in open arm before/after self-admin	0.6	0.6	0.6	-0.7	0.8
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.1	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.3	-0.2
Active lever presses in extinction session 6	1.7	1.7	1.7	-1.3	1.3
Delta distance traveled before/after self-admin	0.8	0.8	0.8	-0.9	0.9
Delta ambulatory time before/after self-admin	2.1	2.3	2.3	-1.5	1.5
Time in closed arm before self-admin	6.3	7.2	7.4	2.7	-2.7
Time in closed arm after self-admin	3.1	3.2	3.5	1.7	-1.9
Time in open arm before self-admin	6.9	7.4	7.4	-2.7	2.7
Time in open arm after self-admin	6.3	6.9	7.2	-2.6	2.7
Sum of active levers in priming session hrs 5-6	0.7	0.7	0.7	0.8	-0.8
Time to tail flick, vehicle, before self-admin	1.8	1.8	1.9	-1.3	1.4
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.4	-0.6	0.6
Time to tail flick, test, before self-admin	0.0	0.0	0.0	-0.1	0.1
Time to tail flick, test, after self-admin	3.5	3.6	3.6	-1.9	1.9
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.2	0.2
Delta time to tail flick, test, before/after SA	3.4	3.0	3.1	-1.7	1.8
Ambulatory time before self-admin	1.6	1.7	1.7	1.3	-1.3
Ambulatory time after self-admin	0.1	0.1	0.1	0.2	-0.3
Total heroin consumption	1.0	1.1	1.2	-1.0	1.1
Area under the delay curve	0.3	0.3	0.3	0.5	-0.5
Delay disc. indifference point, 0s delay	0.4	0.5	0.5	-0.7	0.7
Delay disc. indifference point, 16s delay	0.5	0.5	0.5	0.7	-0.7
Delay disc. indifference point, 2s delay	1.4	1.5	1.6	1.2	-1.3
Delay disc. indifference point, 24s delay	0.5	0.4	0.5	0.7	-0.7
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.2	0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	0.3	-0.3
Delay discount exponential model param	0.2	0.2	0.2	-0.4	0.4
Delay discount hyperbolic model param	0.2	0.3	0.3	-0.5	0.5
Fecal boli incidents, locomotor time 1	1.3	1.4	1.5	1.2	-1.2
Change in fecal boli incidents, locomotor task	2.5	2.3	2.4	-1.5	1.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.3	0.4
Bouts of movement, locomotor time 1	1.4	1.5	1.6	1.2	-1.2
Total resting periods, locomotor time 1	1.3	1.5	1.5	1.2	-1.2
Rest time, locomotor task time 1	0.0	0.1	0.1	0.2	-0.2
Distance moved, locomotor task time 1	0.5	0.5	0.6	0.7	-0.8
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.1	0.1
Time >=10cm from walls, locomotor time 2	1.0	1.1	1.1	-1.0	1.1
Bouts of movement, locomotor time 2	0.8	0.9	0.9	-1.0	0.9
Total resting periods, locomotor time 2	0.5	0.6	0.6	-0.8	0.7
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.3	0.2
Distance moved, locomotor task time 2	0.4	0.5	0.5	0.7	-0.7
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.2	0.1
Weight adjusted by age	0.3	0.4	0.4	-0.6	0.6
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	0.6	-0.8	0.8
Locomotion in novel chamber	5.6	6.9	7.0	-2.6	2.6
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	0.1	-0.2
Progressive ratio	0.0	0.1	0.1	0.2	-0.3
Food seeking constrained by brief footshock	0.5	0.7	0.7	-0.8	0.8
Seeking ratio, punishment vs. effort	0.4	0.5	0.6	-0.7	0.8
Run reversals in cocaine runway, females	1.8	1.8	1.8	1.3	-1.4
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.0	-0.0
Latency to leave start box in cocaine runway	0.6	0.6	0.6	0.8	-0.8
Latency to leave start box in cocaine runway, F	0.8	0.9	0.9	0.9	-0.9
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	0.5	-0.5
Cd content in liver	1.3	1.5	1.6	-1.2	1.2
Co content in liver	1.9	2.2	2.3	-1.5	1.5
Cu content in liver	2.4	3.0	3.0	1.7	-1.7
Fe content in liver	1.3	1.5	1.6	1.2	-1.2
K content in liver	0.5	0.5	0.6	-0.7	0.7
Mg content in liver	0.2	0.2	0.2	-0.4	0.5
Mn content in liver	0.3	0.3	0.3	-0.6	0.5
Na content in liver	0.2	0.2	0.2	0.4	-0.4
Rb content in liver	0.7	0.9	1.0	-1.0	0.9
Se content in liver	0.0	0.0	0.0	0.1	-0.1
Sr content in liver	0.0	0.0	0.1	-0.2	0.2
Zn content in liver	0.1	0.2	0.2	-0.4	0.4