Pavlov. Cond. latency score

Pavlovian Conditioned Approach, Sign/goal-tracking, average magazine minus lever contact latency on days 4 and 5 of testing, normalized to 1/-1 by dividing by 8 seconds

Tags: Behavior · Learning and memory · Pavlovian conditioned approach

Project: p50_shelly_flagel_2014

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	11	39057816	40174684	1	1	4.6e-09	1.12e-01	1e+00	Epha6

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
Heart weight	4.41	1	0	0	1e+00	Epha6
Parametrial fat weight	18.48	1	1	100	1e+00	Epha6
Intraocular pressure	5.23	1	0	0	1e+00	Epha6
Tibia length	2.39	1	0	0	1e+00	Epha6
Number of licking bursts	4.2	1	0	0	1e+00	Epha6
Food consumed during 24 hour testing period	5.03	1	0	0	1e+00	Epha6
Times rat made contact with spout	14.64	1	0	0	1e+00	Epha6
Water consumed over 24 hours	14.75	1	0	0	1e+00	Epha6
Delay discounting total patch changes 12 sec	14.51	1	0	0	1e+00	Epha6
Delay discounting total patch changes 18 sec	16.27	1	0	0	1e+00	Epha6
Delay discounting total patch changes 6 sec	13.61	1	0	0	1e+00	Epha6
Delay discounting water rate 18 sec	10.22	1	0	0	1e+00	Epha6
Locomotor activity	7.92	1	0	0	1e+00	Epha6
Locomotor testing distance	8.93	1	0	0	1e+00	Epha6
Locomotor testing rearing	2.52	1	0	0	1e+00	Epha6
Light reinforcement 2	3.59	1	0	0	1e+00	Epha6
Reaction time premature initiation rate	7.63	1	0	0	1e+00	Epha6
Reaction time premature initiations	4.08	1	0	0	1e+00	Epha6
Social responses	4.04	1	0	0	1e+00	Epha6
Conditioned locomotion	13.46	1	0	0	1e+00	Epha6
Cocaine response before conditioning	6.4	1	0	0	1e+00	Epha6
Condit. Reinf. lever presses	6.41	1	0	0	1e+00	Epha6
Pavlov. Cond. lever latency	5.89	1	0	0	1e+00	Epha6
Pavlov. Cond. index score	4	1	0	0	1e+00	Epha6
Pavlov. Cond. latency score	3.89	1	0	0	1e+00	Epha6
Pavlov. Cond. lever contacts	7.02	1	0	0	1e+00	Epha6
Pavlov. Cond. magazine entry number	6.55	1	0	0	1e+00	Epha6
Pavlov. Cond. lever-magazine prob. diff.	3.5	1	0	0	1e+00	Epha6
Pavlov. Cond. response bias	4.45	1	0	0	1e+00	Epha6
Conditioned reinforcement - actives	21.6	1	0	0	1e+00	Epha6
Conditioned reinforcement - inactives	31.73	1	1	100	1e+00	Epha6
Intermitt. access day 15 inactive lever presses	3.79	1	0	0	1e+00	Epha6
Intermittent access day 1 total infusions	10.93	1	0	0	1e+00	Epha6
Intermittent access day 15 total infusions	13.64	1	0	0	1e+00	Epha6
Intermittent access terminal intake (last 3 days)	20.14	1	0	0	1e+00	Epha6
Intermittent access total infusions	18.26	1	0	0	1e+00	Epha6
Intermittent access day 1 locomotion	3.84	1	0	0	1e+00	Epha6
Cocaine induced anxiety	17.65	1	0	0	1e+00	Epha6
Post-drug Anxiety	5.89	1	0	0	1e+00	Epha6
Baseline Anxiety	19.75	1	0	0	1e+00	Epha6
Lifetime Intake	33.5	1	1	100	1e+00	Epha6
Incentive Sensitization - Responses	8.04	1	0	0	1e+00	Epha6
Incentive Sensitization - Breakpoint	8	1	0	0	1e+00	Epha6
Progressive ratio test 1 active lever presses	24.64	1	0	0	1e+00	Epha6
Progressive ratio test 1 breakpoint	29.27	1	1	100	1e+00	Epha6
Progressive ratio test 1 inactive lever presses	8.22	1	0	0	1e+00	Epha6
Progressive ratio test 2 active lever presses	30.7	1	1	100	1e+00	Epha6
Progressive ratio test 2 breakpoint	23.99	1	1	100	1e+00	Epha6
Progressive ratio test 2 inactive lever presses	29.19	1	1	100	1e+00	Epha6
Total sessions with >9 infusions	18.38	1	0	0	1e+00	Epha6
Short access day 1 total inactive lever presses	6.36	1	0	0	1e+00	Epha6
Short access day 1 total infusions	39.99	1	1	100	1e+00	Epha6
Short access day 10 total infusions	4.95	1	0	0	1e+00	Epha6
Short access total infusions	43.87	1	1	100	1e+00	Epha6
One hour access (0.3 mA shock)	36.93	1	1	100	1e+00	Epha6
One hour access (shock baseline)	19.69	1	0	0	1e+00	Epha6
Locomotion distance, session 1	11.43	1	0	0	1e+00	Epha6
Locomotion velocity, session 2	3.85	1	0	0	1e+00	Epha6
Locomotion distance, session 2	3.63	1	0	0	1e+00	Epha6
Stereotopy head waving bouts, day 3	8.94	1	0	0	1e+00	Epha6
Stereotopy head waving duration, day 3	4.63	1	0	0	1e+00	Epha6
Locomotion velocity, session 7	7.71	1	0	0	1e+00	Epha6
Locomotion distance, session 7	11.27	1	0	0	1e+00	Epha6
Locomotion distance, session 8	5.5	1	0	0	1e+00	Epha6
Degree of sensitization distance	6.07	1	0	0	1e+00	Epha6
Condit. Reinf. active minus inactive responses	9.43	1	0	0	1e+00	Epha6
Condit. Reinf. active-inactive response ratio	9.45	1	0	0	1e+00	Epha6
Condit. Reinf. active responses	9.65	1	0	0	1e+00	Epha6
Incentive salience index mean	10.79	1	0	0	1e+00	Epha6
Condit. Reinf. lever presses	10.96	1	0	0	1e+00	Epha6
Time in familiar zone, hab. session 1	9.82	1	0	0	1e+00	Epha6
Time in novel zone, hab. session 1	6.18	1	0	0	1e+00	Epha6
Total zone transitions, hab. session 1	8.13	1	0	0	1e+00	Epha6
Total locomotion distance, hab. session 1	4.8	1	0	0	1e+00	Epha6
Locomotion velocity, hab. session 1	8.12	1	0	0	1e+00	Epha6
Time in familiar zone, hab. session 2	37.26	1	1	100	1e+00	Epha6
Time in novel zone, hab. session 2	30.02	1	1	100	1e+00	Epha6
Total zone transitions, hab. session 2	7.43	1	0	0	1e+00	Epha6
Total locomotion distance, hab. session 2	8.86	1	0	0	1e+00	Epha6
Locomotion velocity, hab. session 2	8.97	1	0	0	1e+00	Epha6
Novelty place preference	5.77	1	0	0	1e+00	Epha6
Pavlov. Cond. lever latency	19.53	1	0	0	1e+00	Epha6
Pavlov. Cond. magazine entry latency	35.19	1	1	100	1e+00	Epha6
Pavlov. Cond. change in total contacts	8.22	1	0	0	1e+00	Epha6
Pavlov. Cond. index score	29.2	1	1	100	1e+00	Epha6
Pavlov. Cond. lever contacts	25.56	1	1	100	1e+00	Epha6
Pavlov. Cond. magazine entry number	14.74	1	0	0	1e+00	Epha6
Pavlov. Cond. lever-magazine prob. diff.	27.57	1	1	100	1e+00	Epha6
Pavlov. Cond. response bias	29.69	1	1	100	1e+00	Epha6
Bone surface	4.16	1	0	0	1e+00	Epha6
Bone: connectivity density	3.43	1	0	0	1e+00	Epha6
Bone: cortical area	3.28	1	0	0	1e+00	Epha6
Bone: cortical porosity	5.58	1	0	0	1e+00	Epha6
Bone: cortical thickness	13.93	1	0	0	1e+00	Epha6
Bone: endosteal estimation	2.53	1	0	0	1e+00	Epha6
Bone: marrow area	2.29	1	0	0	1e+00	Epha6
Bone: maximum diameter	7.31	1	0	0	1e+00	Epha6
Bone: periosteal estimation	2.98	1	0	0	1e+00	Epha6
Bone: periosteal perimeter	4.91	1	0	0	1e+00	Epha6
Bone: stiffness	7.81	1	0	0	1e+00	Epha6
Time to tail flick, test, before self-admin	6.51	1	0	0	1e+00	Epha6
Delta time to tail flick, vehicle, before/after SA	8.08	1	0	0	1e+00	Epha6
Total heroin consumption	5.1	1	0	0	1e+00	Epha6
Delay disc. indifference point, 0s delay	11.8	1	0	0	1e+00	Epha6
Delay disc. indifference point, 2s delay	3.57	1	0	0	1e+00	Epha6
Delay disc. indifference point, 4s delay	9.29	1	0	0	1e+00	Epha6
Delay disc. indifference point, 8s delay	5.52	1	0	0	1e+00	Epha6
Delay discount exponential model param	3.67	1	0	0	1e+00	Epha6
Delay discount hyperbolic model param	4.06	1	0	0	1e+00	Epha6
Time >=10cm from walls, locomotor time 1	6.04	1	0	0	1e+00	Epha6
Bouts of movement, locomotor time 1	7.86	1	0	0	1e+00	Epha6
Total resting periods, locomotor time 1	4.03	1	0	0	1e+00	Epha6
Vertical activity count, locomotor time 1	3.93	1	0	0	1e+00	Epha6
Total resting periods, locomotor time 2	4.65	1	0	0	1e+00	Epha6
Rest time, locomotor task time 2	5.68	1	0	0	1e+00	Epha6
Distance moved, locomotor task time 2	3.47	1	0	0	1e+00	Epha6
Vertical activity count, locomotor time 2	4.77	1	0	0	1e+00	Epha6
Seeking ratio, delayed vs. immediate footshock	11.18	1	0	0	1e+00	Epha6
Locomotion in novel chamber post-restriction	15.51	1	0	0	1e+00	Epha6
Latency to leave start box in cocaine runway	10.3	1	0	0	1e+00	Epha6
Latency to leave start box in cocaine runway, F	4.21	1	0	0	1e+00	Epha6
Na content in liver	9.4	1	0	0	1e+00	Epha6
Se content in liver	13.19	1	0	0	1e+00	Epha6

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.28
Adipose	alternative TSS	0	0	1.21
Adipose	gene expression	0	0	1.28
Adipose	isoform ratio	0	0	1.26
Adipose	intron excision ratio	0	0	1.29
Adipose	mRNA stability	0	0	1.25
BLA	alternative polyA	0	0	1.31
BLA	alternative TSS	0	0	1.36
BLA	gene expression	0	0	1.25
BLA	isoform ratio	0	0	1.27
BLA	intron excision ratio	0	0	1.43
BLA	mRNA stability	0	0	1.23
Brain	alternative polyA	0	0	1.24
Brain	alternative TSS	0	0	1.31
Brain	gene expression	0	0	1.27
Brain	isoform ratio	0	0	1.29
Brain	intron excision ratio	0	0	1.4
Brain	mRNA stability	0	0	1.26
Eye	alternative polyA	0	0	1.29
Eye	alternative TSS	0	0	1.44
Eye	gene expression	0	0	1.26
Eye	isoform ratio	0	0	1.25
Eye	intron excision ratio	0	0	1.21
Eye	mRNA stability	0	0	1.34
IL	alternative polyA	0	0	1.24
IL	alternative TSS	0	0	1.53
IL	gene expression	0	0	1.24
IL	isoform ratio	0	0	1.41
IL	intron excision ratio	0	0	1.49
IL	mRNA stability	0	0	1.22
LHb	alternative polyA	0	0	1.28
LHb	alternative TSS	0	0	1.43
LHb	gene expression	0	0	1.25
LHb	isoform ratio	0	0	1.37
LHb	intron excision ratio	0	0	1.54
LHb	mRNA stability	0	0	1.24
Liver	alternative polyA	0	0	1.22
Liver	alternative TSS	0	0	1.26
Liver	gene expression	0	0	1.24
Liver	isoform ratio	0	0	1.17
Liver	intron excision ratio	0	0	1.22
Liver	mRNA stability	0	0	1.19
NAcc	alternative polyA	0	0	1.23
NAcc	alternative TSS	0	0	1.19
NAcc	gene expression	0	0	1.24
NAcc	isoform ratio	0	0	1.31
NAcc	intron excision ratio	0	0	1.44
NAcc	mRNA stability	0	0	1.22
OFC	alternative polyA	0	0	1.2
OFC	alternative TSS	0	0	1.46
OFC	gene expression	0	0	1.24
OFC	isoform ratio	0	0	1.48
OFC	intron excision ratio	0	0	1.53
OFC	mRNA stability	0	0	1.24
PL	alternative polyA	0	0	1.26
PL	alternative TSS	1	0.1	1.43
PL	gene expression	0	0	1.26
PL	isoform ratio	0	0	1.29
PL	intron excision ratio	0	0	1.39
PL	mRNA stability	0	0	1.23