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Pavlov. Cond. latency score

Pavlovian Conditioned Approach, Sign/goal-tracking, average magazine minus lever contact latency on days 4 and 5 of testing, normalized to 1/-1 by dividing by 8 seconds

Tags: Behavior · Learning and memory · Pavlovian conditioned approach

Project: p50_shelly_flagel_2014

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 39057816 40174684 1 1 4.6e-09 0.11 1 100 Epha6

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Heart weight 4.4 1 0 0 0 1 Epha6
Parametrial fat weight 18.5 1 1 100 0 1 Epha6
Intraocular pressure 5.2 1 0 0 0 1 Epha6
Tibia length 2.4 1 0 0 0 1 Epha6
Number of licking bursts 4.2 1 0 0 0 1 Epha6
Food consumed during 24 hour testing period 5.0 1 0 0 0 1 Epha6
Times rat made contact with spout 14.6 1 0 0 0 1 Epha6
Water consumed over 24 hours 14.8 1 0 0 0 1 Epha6
Delay discounting total patch changes 12 sec 14.5 1 0 0 0 1 Epha6
Delay discounting total patch changes 18 sec 16.3 1 0 0 0 1 Epha6
Delay discounting total patch changes 6 sec 13.6 1 0 0 0 1 Epha6
Delay discounting water rate 18 sec 10.2 1 0 0 0 1 Epha6
Locomotor activity 7.9 1 0 0 0 1 Epha6
Locomotor testing distance 8.9 1 0 0 0 1 Epha6
Locomotor testing rearing 2.5 1 0 0 0 1 Epha6
Light reinforcement 2 3.6 1 0 0 0 1 Epha6
Reaction time premature initiation rate 7.6 1 0 0 0 1 Epha6
Reaction time premature initiations 4.1 1 0 0 0 1 Epha6
Social responses 4.0 1 0 0 0 1 Epha6
Conditioned locomotion 13.5 1 0 0 0 1 Epha6
Cocaine response before conditioning 6.4 1 0 0 0 1 Epha6
Condit. Reinf. lever presses 6.4 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 5.9 1 0 0 0 1 Epha6
Pavlov. Cond. index score 4.0 1 0 0 0 1 Epha6
Pavlov. Cond. latency score 3.9 1 0 0 0 1 Epha6
Pavlov. Cond. lever contacts 7.0 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry number 6.5 1 0 0 0 1 Epha6
Pavlov. Cond. lever-magazine prob. diff. 3.5 1 0 0 0 1 Epha6
Pavlov. Cond. response bias 4.5 1 0 0 0 1 Epha6
Conditioned reinforcement - actives 21.6 1 0 0 0 1 Epha6
Conditioned reinforcement - inactives 31.7 1 1 100 0 1 Epha6
Intermitt. access day 15 inactive lever presses 3.8 1 0 0 0 1 Epha6
Intermittent access day 1 total infusions 10.9 1 0 0 0 1 Epha6
Intermittent access day 15 total infusions 13.6 1 0 0 0 1 Epha6
Intermittent access terminal intake (last 3 days) 20.1 1 0 0 0 1 Epha6
Intermittent access total infusions 18.3 1 0 0 0 1 Epha6
Intermittent access day 1 locomotion 3.8 1 0 0 0 1 Epha6
Cocaine induced anxiety 17.6 1 0 0 0 1 Epha6
Post-drug Anxiety 5.9 1 0 0 0 1 Epha6
Baseline Anxiety 19.8 1 0 0 0 1 Epha6
Lifetime Intake 33.5 1 1 100 0 1 Epha6
Incentive Sensitization - Responses 8.0 1 0 0 0 1 Epha6
Incentive Sensitization - Breakpoint 8.0 1 0 0 0 1 Epha6
Progressive ratio test 1 active lever presses 24.6 1 0 0 0 1 Epha6
Progressive ratio test 1 breakpoint 29.3 1 1 100 0 1 Epha6
Progressive ratio test 1 inactive lever presses 8.2 1 0 0 0 1 Epha6
Progressive ratio test 2 active lever presses 30.7 1 1 100 0 1 Epha6
Progressive ratio test 2 breakpoint 24.0 1 1 100 0 1 Epha6
Progressive ratio test 2 inactive lever presses 29.2 1 1 100 0 1 Epha6
Total sessions with >9 infusions 18.4 1 0 0 0 1 Epha6
Short access day 1 total inactive lever presses 6.4 1 0 0 0 1 Epha6
Short access day 1 total infusions 40.0 1 1 100 0 1 Epha6
Short access day 10 total infusions 5.0 1 0 0 0 1 Epha6
Short access total infusions 43.9 1 1 100 0 1 Epha6
One hour access (0.3 mA shock) 36.9 1 1 100 0 1 Epha6
One hour access (shock baseline) 19.7 1 0 0 0 1 Epha6
Locomotion distance, session 1 11.4 1 0 0 0 1 Epha6
Locomotion velocity, session 2 3.9 1 0 0 0 1 Epha6
Locomotion distance, session 2 3.6 1 0 0 0 1 Epha6
Stereotopy head waving bouts, day 3 8.9 1 0 0 0 1 Epha6
Stereotopy head waving duration, day 3 4.6 1 0 0 0 1 Epha6
Locomotion velocity, session 7 7.7 1 0 0 0 1 Epha6
Locomotion distance, session 7 11.3 1 0 0 0 1 Epha6
Locomotion distance, session 8 5.5 1 0 0 0 1 Epha6
Degree of sensitization distance 6.1 1 0 0 0 1 Epha6
Condit. Reinf. active minus inactive responses 9.4 1 0 0 0 1 Epha6
Condit. Reinf. active-inactive response ratio 9.4 1 0 0 0 1 Epha6
Condit. Reinf. active responses 9.7 1 0 0 0 1 Epha6
Incentive salience index mean 10.8 1 0 0 0 1 Epha6
Condit. Reinf. lever presses 11.0 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 1 9.8 1 0 0 0 1 Epha6
Time in novel zone, hab. session 1 6.2 1 0 0 0 1 Epha6
Total zone transitions, hab. session 1 8.1 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 1 4.8 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 1 8.1 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 2 37.3 1 1 100 0 1 Epha6
Time in novel zone, hab. session 2 30.0 1 1 100 0 1 Epha6
Total zone transitions, hab. session 2 7.4 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 2 8.9 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 2 9.0 1 0 0 0 1 Epha6
Novelty place preference 5.8 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 19.5 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry latency 35.2 1 1 100 0 1 Epha6
Pavlov. Cond. change in total contacts 8.2 1 0 0 0 1 Epha6
Pavlov. Cond. index score 29.2 1 1 100 0 1 Epha6
Pavlov. Cond. lever contacts 25.6 1 1 100 0 1 Epha6
Pavlov. Cond. magazine entry number 14.7 1 0 0 0 1 Epha6
Pavlov. Cond. lever-magazine prob. diff. 27.6 1 1 100 0 1 Epha6
Pavlov. Cond. response bias 29.7 1 1 100 0 1 Epha6
Bone surface 4.2 1 0 0 0 1 Epha6
Bone: connectivity density 3.4 1 0 0 0 1 Epha6
Bone: cortical area 3.3 1 0 0 0 1 Epha6
Bone: cortical porosity 5.6 1 0 0 0 1 Epha6
Bone: cortical thickness 13.9 1 0 0 0 1 Epha6
Bone: endosteal estimation 2.5 1 0 0 0 1 Epha6
Bone: marrow area 2.3 1 0 0 0 1 Epha6
Bone: maximum diameter 7.3 1 0 0 0 1 Epha6
Bone: periosteal estimation 3.0 1 0 0 0 1 Epha6
Bone: periosteal perimeter 4.9 1 0 0 0 1 Epha6
Bone: stiffness 7.8 1 0 0 0 1 Epha6
Time to tail flick, test, before self-admin 6.5 1 0 0 0 1 Epha6
Delta time to tail flick, vehicle, before/after SA 8.1 1 0 0 0 1 Epha6
Total heroin consumption 5.1 1 0 0 0 1 Epha6
Delay disc. indifference point, 0s delay 11.8 1 0 0 0 1 Epha6
Delay disc. indifference point, 2s delay 3.6 1 0 0 0 1 Epha6
Delay disc. indifference point, 4s delay 9.3 1 0 0 0 1 Epha6
Delay disc. indifference point, 8s delay 5.5 1 0 0 0 1 Epha6
Delay discount exponential model param 3.7 1 0 0 0 1 Epha6
Delay discount hyperbolic model param 4.1 1 0 0 0 1 Epha6
Time >=10cm from walls, locomotor time 1 6.0 1 0 0 0 1 Epha6
Bouts of movement, locomotor time 1 7.9 1 0 0 0 1 Epha6
Total resting periods, locomotor time 1 4.0 1 0 0 0 1 Epha6
Vertical activity count, locomotor time 1 3.9 1 0 0 0 1 Epha6
Total resting periods, locomotor time 2 4.7 1 0 0 0 1 Epha6
Rest time, locomotor task time 2 5.7 1 0 0 0 1 Epha6
Distance moved, locomotor task time 2 3.5 1 0 0 0 1 Epha6
Vertical activity count, locomotor time 2 4.8 1 0 0 0 1 Epha6
Seeking ratio, delayed vs. immediate footshock 11.2 1 0 0 0 1 Epha6
Locomotion in novel chamber post-restriction 15.5 1 0 0 0 1 Epha6
Latency to leave start box in cocaine runway 10.3 1 0 0 0 1 Epha6
Latency to leave start box in cocaine runway, F 4.2 1 0 0 0 1 Epha6
Na content in liver 9.4 1 0 0 0 1 Epha6
Se content in liver 13.2 1 0 0 0 1 Epha6

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 0 0.000 1.2
Adipose gene expression 0 0.000 1.3
Adipose isoform ratio 0 0.000 1.3
Adipose intron excision ratio 0 0.000 1.3
Adipose mRNA stability 0 0.000 1.3
BLA alternative polyA 0 0.000 1.3
BLA alternative TSS 0 0.000 1.4
BLA gene expression 0 0.000 1.3
BLA isoform ratio 0 0.000 1.3
BLA intron excision ratio 0 0.000 1.4
BLA mRNA stability 0 0.000 1.2
Brain alternative polyA 0 0.000 1.2
Brain alternative TSS 0 0.000 1.3
Brain gene expression 0 0.000 1.3
Brain isoform ratio 0 0.000 1.3
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.3
Eye alternative polyA 0 0.000 1.3
Eye alternative TSS 0 0.000 1.4
Eye gene expression 0 0.000 1.3
Eye isoform ratio 0 0.000 1.3
Eye intron excision ratio 0 0.000 1.2
Eye mRNA stability 0 0.000 1.3
IL alternative polyA 0 0.000 1.2
IL alternative TSS 0 0.000 1.5
IL gene expression 0 0.000 1.2
IL isoform ratio 0 0.000 1.4
IL intron excision ratio 0 0.000 1.5
IL mRNA stability 0 0.000 1.2
LHb alternative polyA 0 0.000 1.3
LHb alternative TSS 0 0.000 1.4
LHb gene expression 0 0.000 1.2
LHb isoform ratio 0 0.000 1.4
LHb intron excision ratio 0 0.000 1.5
LHb mRNA stability 0 0.000 1.2
Liver alternative polyA 0 0.000 1.2
Liver alternative TSS 0 0.000 1.3
Liver gene expression 0 0.000 1.2
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.2
Liver mRNA stability 0 0.000 1.2
NAcc alternative polyA 0 0.000 1.2
NAcc alternative TSS 0 0.000 1.2
NAcc gene expression 0 0.000 1.2
NAcc isoform ratio 0 0.000 1.3
NAcc intron excision ratio 0 0.000 1.4
NAcc mRNA stability 0 0.000 1.2
OFC alternative polyA 0 0.000 1.2
OFC alternative TSS 0 0.000 1.5
OFC gene expression 0 0.000 1.2
OFC isoform ratio 0 0.000 1.5
OFC intron excision ratio 0 0.000 1.5
OFC mRNA stability 0 0.000 1.2
PL alternative polyA 0 0.000 1.3
PL alternative TSS 1 0.085 1.4
PL gene expression 0 0.000 1.3
PL isoform ratio 0 0.000 1.3
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 0 0.000 1.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.